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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMA7 Gene

protein-coding   GIFtS: 67
GCID: GC20M060711

Proteasome (Prosome, Macropain) Subunit, Alpha Type, 7

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proteasome (Prosome, Macropain) Subunit, Alpha Type, 71 2     C62
Proteasome Subunit RC6-11 2 3     RC6-12
Proteasome Subunit XAPC71 2 3     XAPC72
HSPC2 3     Proteasome Subunit Alpha 42
EC 3.4.25.13 8     Proteasome Subunit Alpha Type-72

External Ids:    HGNC: 95361   Entrez Gene: 56882   Ensembl: ENSG000001011827   OMIM: 6066075   UniProtKB: O148183   

Export aliases for PSMA7 gene to outside databases

Previous GC identifers: GC20M060475 GC20M061350 GC20M061397 GC20M060145 GC20M057489


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMA7 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout
eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a
non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha
subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating
hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The
encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha.
A pseudogene of this gene is located on the long arm of chromosome 9. (provided by RefSeq, Jul 2012)

GeneCards Summary for PSMA7 Gene: 
PSMA7 (proteasome (prosome, macropain) subunit, alpha type, 7) is a protein-coding gene. Diseases associated with PSMA7 include hepatitis b, and hepatitis c, and among its related super-pathways are Regulation of APC/C activators between G1/S and early anaphase and Mitotic Anaphase. GO annotations related to this gene include threonine-type endopeptidase activity and identical protein binding. An important paralog of this gene is PSMA8.

UniProtKB/Swiss-Prot: PSA7_HUMAN, O14818
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell
proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell
differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor
regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the
transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with
EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in
hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the
androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and
thereby negatively regulates MAVS-mediated innate immune response

Gene Wiki entry for PSMA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMA7 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMA7 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMA7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

PSMA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMA7 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M060711:  view genomic region     (about GC identifiers)

Start:
60,711,791 bp from pter      End:
60,718,496 bp from pter
Size:
6,706 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PSA7_HUMAN, O14818 (See protein sequence)
Recommended Name: Proteasome subunit alpha type-7  
Size: 248 amino acids; 27887 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome
core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure.
The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven
beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA7 interacts
directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Interacts with HIV-1 TAT
protein. Interacts with hepatitis B virus X protein (HBX). Interacts with HIF1A. Interacts with RAB7A. Interacts
with PARK2. Interacts with ABL1 and ABL2. Interacts with EMAP2. Interacts with MAVS
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B2R515 Q5JXJ2 Q9BR53 Q9H4K5 Q9UEU8
Alternative splicing: 3 isoforms:  O14818-1   O14818-2   O14818-4   

Explore the universe of human proteins at neXtProt for PSMA7: NX_O14818

Explore proteomics data for PSMA7 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14818

  • 4/15 DME Specific Peptides for PSMA7 (O14818) (see all 15)
     RARVECQ  RTVRKIC  EKKKQKK  LFQVEYA 

    PSMA7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PSMA7 Protein Expression
    REFSEQ proteins: NP_002783.1  
    ENSEMBL proteins: 
     ENSP00000397047   ENSP00000359910   ENSP00000359898   ENSP00000359895  
    Reactome Protein details: O14818
    Human Recombinant Protein Products for PSMA7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
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    OriGene Purified Protein for PSMA7
    OriGene Protein Over-expression Lysate for PSMA7
    OriGene MassSpec for PSMA7 
    OriGene Custom Protein Services for PSMA7
    GenScript Custom Purified and Recombinant Proteins Services for PSMA7
    Novus Biologicals PSMA7 Proteins
    Novus Biologicals PSMA7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PSMA7
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005839proteasome core complex ISS--
    GO:0019773proteasome core complex, alpha-subunit complex IEA--

    PSMA7 for ontologies           About GeneDecksing



    PSMA7 Antibody Products: 
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    Abcam antibodies for PSMA7
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    ThermoFisher Antibody for PSMA7
    LSBio Antibodies in human, mouse, rat for PSMA7 

    Assay Products for PSMA7: 
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    OriGene Custom Assay Services for PSMA7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PSMA7
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PSM: Proteasome (prosome, macropain) subunits

    3 InterPro protein domains:
     IPR001353 Proteasome_sua/b
     IPR000426 Proteasome_asu_N
     IPR023332 Proteasome_suA-type

    Graphical View of Domain Structure for InterPro Entry O14818

    ProtoNet protein and cluster: O14818

    1 Blocks protein domain: IPB000426 Proteasome subunit

    UniProtKB/Swiss-Prot: PSA7_HUMAN, O14818
    Similarity: Belongs to the peptidase T1A family


    PSMA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSA7_HUMAN, O14818
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell
    proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell
    differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor
    regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the
    transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with
    EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in
    hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the
    androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and
    thereby negatively regulates MAVS-mediated innate immune response
    Catalytic activity: Cleavage of peptide bonds with very broad specificity
    Induction: Down-regulated by the ribozyme Rz3'X. Up-regulated in colorectal cancer tissues

         Enzyme Number (IUBMB): EC 3.4.25.11 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity ----
    GO:0004298threonine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI12376572
    GO:0042802identical protein binding IPI15225636
         
    PSMA7 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PSMA7:
     Decreased viability with pacli  G2 arrest  Increased G2M DNA content  Increased gamma-H2AX phosphory 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PSMA7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PSMA7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSMA7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSMA7 

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PSMA7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMA7

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of PSMA7

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: PSMA7 (NM_002792)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMA7
    Sirion Biotech Customized lentivirus for stable overexpression of PSMA7 
                         Customized lentivirus expression plasmids for stable overexpression of PSMA7 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMA7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PSMA7 About   (see all 30)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Removal of licensing factors from origins0.89
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    Regulation of DNA replication0.89
    CDK-mediated phosphorylation and removal of Cdc60.94
    Cyclin E associated events during G1/S transition 0.89
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Switching of origins to a post-replicative state0.89
    2M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    3Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    4Metabolism of mRNA
    Metabolism of RNA0.92
    Metabolism of mRNA0.92
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PSMA7
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMA7 (see all 18)
        CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    p53 Signaling
    DNA Repair Mechanisms

    4 GeneGo (Thomson Reuters) Pathways for PSMA7
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR

    1 BioSystems Pathway for PSMA7
        Proteasome Degradation

    5/74        Reactome Pathways for PSMA7 (see all 74)
        Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway
    CDT1 association with the CDC6:ORC:origin complex
    Autodegradation of the E3 ubiquitin ligase COP1


    1         Kegg Pathway  (Kegg details for PSMA7):
        Proteasome


    PSMA7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/294 Interacting proteins for PSMA7 (O148181, 2, 3 ENSP000003599104) via UniProtKB, MINT, STRING, and/or I2D (see all 294)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMA1P257861, 2, 3EBI-603272,EBI-359352 MINT-6176052 MINT-51353 MINT-6176676 MINT-4050722 MINT-51341 MINT-6176430 MINT-51366 MINT-51332 MINT-6176080 I2D: score=9 
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    PSMA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PSMA7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSMA7 (PSA7)

    3 DrugBank Compounds for PSMA7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE-- --target--10592235
    2-ACETYLAMINO-4-METHYL-PENTANOIC ACID [1-(1-FORMYL-PENTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDE-- --target--10592235
    N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about PSMA7 / PSA7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PSMA7 gene (2 alternative transcripts): 
    NM_002792.3  NM_152255.1  

    Unigene Cluster for PSMA7:

    Proteasome (prosome, macropain) subunit, alpha type, 7
    Hs.233952  [show with all ESTs]
    Unigene Representative Sequence: BF217755
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442551 ENST00000370873(uc002ybx.1) ENST00000484488 ENST00000370861
    ENST00000486193 ENST00000370858
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMA7

    Additional mRNA sequence: 

    AF022815.1 AF054185.1 AK312025.1 BC001895.1 BC004427.1 BC014999.1 BT007165.1 

    24 DOTS entries:

    DT.91775307  DT.100677049  DT.100839828  DT.92414845  DT.97838342  DT.100677043  DT.100847712  DT.100054664 
    DT.100060044  DT.95378804  DT.97838362  DT.100060050  DT.100051468  DT.100060040  DT.100060046  DT.100677041 
    DT.91775310  DT.91843012  DT.91939431  DT.91958119  DT.95216996  DT.97838375  DT.100687117  DT.121636752 

    24/760 AceView cDNA sequences (see all 760):

    CR600945 CR621598 BE407483 AI685499 CR615593 BI906714 AI874409 CR616396 
    AI798506 CR603718 BU739901 AA312575 AA953064 AI240262 BU674237 BQ010685 
    AI520958 AA352352 CB117337 AA459678 BM723703 BM823865 BU685988 BE395471 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PSMA7 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                          -     -           -                 -     -                       -                       -         
    SP2:                          -     -           -           -     -     -     -                 -                                 
    SP3:                          -     -           -                       -                                                         
    SP4:                                -           -                 -     -                                                         
    SP5:                                            -                       -                       -                                 


    ECgene alternative splicing isoforms for PSMA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAGTCTC
    PSMA7 Expression
    About this image


    See PSMA7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMA7

    SOURCE GeneReport for Unigene cluster: Hs.233952
        SABiosciences Custom PCR Arrays for PSMA7
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMA7 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psma71 , 5 proteasome (prosome, macropain) subunit, alpha type more1, 5 90.86(n)1
    98.79(a)1
      2 (102.55 cM)5
    264441  NM_011969.11  NP_036099.11 
     1800363735 
    chicken
    (Gallus gallus)
    Aves PSMA71 proteasome (prosome, macropain) subunit, alpha type, more 83.33(n)
    96.37(a)
      395318  NM_204613.1  NP_989944.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMA76
    Proteasome subunit alpha type
    97(a)
    1 ↔ 1
    4(150627910-150638162)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB027463.12   -- 79.78(n)    AB027463.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.28132 Oncorhynchus mykiss transcribed sequence with strong more 79.28(n)    BX881750.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pros28.13 ATP-dependent proteolysis proteasome
    endopeptidase
    68(a)
    (best of 3)
      14B3   --
    worm
    (Caenorhabditis elegans)
    Secernentea pas-46
    Proteasome subunit alpha type-7
    60(a)
    1 → many
    I(8727214-8728534)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRE6(YOL038W)4 Alpha 4 subunit of the 20S proteasome; may replace more   --   15(255337-256101) 854119  NP_014604.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.25872 Transcribed sequence with strong similarity to protein more 75.14(n)    BI469378.1 
    rice
    (Oryza sativa)
    Liliopsida AK098875.12   -- 79.22(n)    AK098875.1 


    ENSEMBL Gene Tree for PSMA7 (if available)
    TreeFam Gene Tree for PSMA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSMA7 gene
    PSMA82  
    8 SIMAP similar genes for PSMA7 using alignment to 3 protein entries:     PSA7_HUMAN (see all proteins):
    PSMA8    DKFZp686D09174    PSMA5    PSMA2    PSMA4    PSMA1
    PSMA6    PSMA3

    PSMA7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PSMA7
    PGOHUM00000236715


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/187 SNPs in PSMA7 are shown (see all 187)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106674521,2
    C--60711298(+) GACCA-/GAGGAGGA 1 -- cds10--------
    rs339642621,2
    C--60711299(+) ACCAG-/GAGAGGAC 1 -- cds10--------
    rs353135781,2
    C--60711300(+) GAGGA-/GGACCCAA 1 -- cds10--------
    rs1464345881,2
    --60711320(+) TAAACG/TGTGGG 1 -- ds50010--------
    rs1478983911,2
    --60711330(+) GACTAC/GAAGTC 1 -- ds50010--------
    rs1828383721,2
    --60711337(+) AGTCAA/CAACAC 1 -- ds50010--------
    rs1416983811,2
    --60711408(+) GGTCTA/GTGAAA 1 -- ds50010--------
    rs1504541431,2
    --60711488(+) GTGTCC/GTTGAC 1 -- ds50010--------
    rs1871229121,2
    --60711621(+) TCTGAA/CTTCCC 1 -- ds50010--------
    rs61219051,2
    H--60711629(+) CCCAAG/AGGAGG 1 -- ds50014Minor allele frequency- A:0.00NS EA 412

    HapMap Linkage Disequilibrium report for PSMA7 (60711791 - 60718496 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PSMA7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1006840CNV Deletion20482838
    nsv509782CNV Insertion20534489
    nsv3440CNV Insertion18451855
    esv22512CNV Loss19812545
    nsv913033CNV Loss21882294
    dgv4597n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): PSMA7
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606607    OMIM disorders: --

    12 diseases for PSMA7:    About MalaCards
    hepatitis b    hepatitis c    hypoxia    hepatitis
    glaucoma    huntington's disease    retinoblastoma    parkinson's disease
    colorectal cancer    endotheliitis    prostate cancer    prostatitis


    PSMA7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PSMA7
    Human Genome Epidemiology (HuGE) Navigator: PSMA7 (1 document)

    Export disorders for PSMA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMA7 gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with PSMA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteasome complex as a potential cellular target of hepatitis B virus X protein. (PubMed id 8764072)1, 2, 3 Huang J.... Liang T.J. (1996)
    2. Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. (PubMed id 11389899)1, 2, 9 Cho S....Ryu S.E. (2001)
    3. Negative regulation of MAVS-mediated innate immune response by PSMA7. (PubMed id 19734229)1, 2 Jia Y.... Zhong H. (2009)
    4. Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. (PubMed id 19362550)1, 2 Tandle A.T....Libutti S.K. (2009)
    5. PSMA7, a potential biomarker of diseases. (PubMed id 19442227)1, 2 Du H.... Li M. (2009)
    6. The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer. (PubMed id 18202793)1, 2 Hu X.T....He C. (2008)
    7. Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. (PubMed id 16678104)1, 2 Liu X....Cao C. (2006)
    8. Parkin interacts with the proteasome subunit alpha4. (PubMed id 15987638)1, 2 Dachsel J.C....Gasser T. (2005)
    9. A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. (PubMed id 16251969)1, 2 Hirano Y.... Murata S. (2005)
    10. The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes. (PubMed id 14998988)1, 2 Dong J.... Wandinger-Ness A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5688 HGNC: 9536 AceView: PSMA7 Ensembl:ENSG00000101182 euGenes: HUgn5688
    ECgene: PSMA7 Kegg: 5688 H-InvDB: PSMA7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PSMA7 gene:
    Search GeneIP for patents involving PSMA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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