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Aliases for PSMA7 Gene

Aliases for PSMA7 Gene

  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 7 2 3
  • Proteasome Subunit XAPC7 2 3 4
  • Proteasome Subunit RC6-1 2 3 4
  • EC 3.4.25.1 4 63
  • HSPC 3 4
  • Proteasome Subunit Alpha Type-7 3
  • Proteasome Subunit Alpha 4 3
  • RC6-1 3
  • XAPC7 3
  • C6 3

External Ids for PSMA7 Gene

Previous GeneCards Identifiers for PSMA7 Gene

  • GC20M060475
  • GC20M061350
  • GC20M061397
  • GC20M060145
  • GC20M060711
  • GC20M057489

Summaries for PSMA7 Gene

Entrez Gene Summary for PSMA7 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMA7 Gene

PSMA7 (Proteasome (Prosome, Macropain) Subunit, Alpha Type, 7) is a Protein Coding gene. Diseases associated with PSMA7 include hepatitis b and hepatitis c. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include identical protein binding and threonine-type endopeptidase activity. An important paralog of this gene is PSMA8.

UniProtKB/Swiss-Prot for PSMA7 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Gene Wiki entry for PSMA7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA7 Gene

Genomics for PSMA7 Gene

Regulatory Elements for PSMA7 Gene

Genomic Location for PSMA7 Gene

Start:
62,136,727 bp from pter
End:
62,143,458 bp from pter
Size:
6,732 bases
Orientation:
Minus strand

Genomic View for PSMA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA7 Gene

Proteins for PSMA7 Gene

  • Protein details for PSMA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14818-PSA7_HUMAN
    Recommended name:
    Proteasome subunit alpha type-7
    Protein Accession:
    O14818
    Secondary Accessions:
    • B2R515
    • Q5JXJ2
    • Q9BR53
    • Q9H4K5
    • Q9UEU8

    Protein attributes for PSMA7 Gene

    Size:
    248 amino acids
    Molecular mass:
    27887 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Interacts with HIV-1 TAT protein. Interacts with hepatitis B virus X protein (HBX). Interacts with HIF1A. Interacts with RAB7A. Interacts with PARK2. Interacts with ABL1 and ABL2. Interacts with EMAP2. Interacts with MAVS.

    Three dimensional structures from OCA and Proteopedia for PSMA7 Gene

    Alternative splice isoforms for PSMA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA7 Gene

Proteomics data for PSMA7 Gene at MOPED

Post-translational modifications for PSMA7 Gene

  • Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks.
  • Ubiquitination at Lys52, Lys61, Lys115, Lys157, Lys174, Lys204, Lys218, and Lys227
  • Glycosylation at Ser130
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PSMA7 Gene

Gene Families for PSMA7 Gene

HGNC:
  • PSM :Proteasome (prosome, macropain) subunits

Protein Domains for PSMA7 Gene

Graphical View of Domain Structure for InterPro Entry

O14818

UniProtKB/Swiss-Prot:

PSA7_HUMAN :
  • O14818
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA7: view

Function for PSMA7 Gene

Molecular function for PSMA7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
UniProtKB/Swiss-Prot Induction: Down-regulated by the ribozyme Rz3X. Up-regulated in colorectal cancer tissues.

Enzyme Numbers (IUBMB) for PSMA7 Gene

Gene Ontology (GO) - Molecular Function for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12376572
GO:0042802 identical protein binding IPI 15225636
genes like me logo Genes that share ontologies with PSMA7: view
genes like me logo Genes that share phenotypes with PSMA7: view

miRNA for PSMA7 Gene

miRTarBase miRNAs that target PSMA7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMA7

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PSMA7 Gene

Localization for PSMA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA7 Gene COMPARTMENTS Subcellular localization image for PSMA7 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005839 proteasome core complex ISS --
genes like me logo Genes that share ontologies with PSMA7: view

Pathways for PSMA7 Gene

SuperPathways for PSMA7 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Complement Pathway
3 Chks in Checkpoint Regulation
4 Class I MHC mediated antigen processing and presentation
5 Cell Cycle, Mitotic
.62
genes like me logo Genes that share pathways with PSMA7: view

Gene Ontology (GO) - Biological Process for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMA7: view

Transcripts for PSMA7 Gene

Unigene Clusters for PSMA7 Gene

Proteasome (prosome, macropain) subunit, alpha type, 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMA7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7:
SP8: - -
SP9: -

Relevant External Links for PSMA7 Gene

GeneLoc Exon Structure for
PSMA7
ECgene alternative splicing isoforms for
PSMA7

Expression for PSMA7 Gene

mRNA expression in normal human tissues for PSMA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMA7 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMA7 Gene

SOURCE GeneReport for Unigene cluster for PSMA7 Gene Hs.233952

genes like me logo Genes that share expressions with PSMA7: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PSMA7 Gene

Orthologs for PSMA7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMA7 35
  • 99.46 (n)
  • 99.6 (a)
PSMA7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMA7 35
  • 93.15 (n)
  • 99.19 (a)
PSMA7 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMA7 35
  • 92.28 (n)
  • 99.07 (a)
PSMA7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psma7 35
  • 90.86 (n)
  • 98.79 (a)
Psma7 16
Psma7 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA7 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psma7 35
  • 91.4 (n)
  • 98.79 (a)
chicken
(Gallus gallus)
Aves PSMA7 35
  • 83.04 (n)
  • 96.52 (a)
PSMA7 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMA7 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75728 35
psma7 35
  • 79.13 (n)
  • 96.96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2813 35
fruit fly
(Drosophila melanogaster)
Insecta Pros28.1 36
  • 68 (a)
ManyToMany
Pros28.1A 36
  • 58 (a)
ManyToMany
Pros28.1B 36
  • 50 (a)
ManyToMany
Pros28.1 37
  • 68 (a)
Pros28.1A 37
  • 59 (a)
Pros28.1B 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea pas-4 35
  • 61.16 (n)
  • 65.62 (a)
pas-4 36
  • 60 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE6 36
  • 56 (a)
OneToMany
PRE6 38
soybean
(Glycine max)
eudicotyledons Gma.2587 35
barley
(Hordeum vulgare)
Liliopsida Hv.3003 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4812 36
  • 76 (a)
OneToMany
Species with no ortholog for PSMA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PSMA7 Gene

ENSEMBL:
Gene Tree for PSMA7 (if available)
TreeFam:
Gene Tree for PSMA7 (if available)

Paralogs for PSMA7 Gene

Paralogs for PSMA7 Gene

Selected SIMAP similar genes for PSMA7 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PSMA7 Gene

genes like me logo Genes that share paralogs with PSMA7: view

Variants for PSMA7 Gene

Sequence variations from dbSNP and Humsavar for PSMA7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs7076 -- 62,138,255(-) GTGCG(C/T)GAGTT reference, synonymous-codon
rs12041 -- 62,138,227(-) CTGAC(A/G)AAGCC missense, reference
rs1047918 -- 62,137,124(-) CTGCT(A/G)CTGCT intron-variant
rs1047919 -- 62,136,979(-) TGTGG(C/T)TTAGG intron-variant
rs1135961 -- 62,138,276(-) ATAGG(C/T)CGGGG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for PSMA7 Gene

Variant ID Type Subtype PubMed ID
dgv4597n71 CNV Loss 21882294
nsv913033 CNV Loss 21882294
nsv509782 CNV Insertion 20534489
esv1006840 CNV Deletion 20482838
nsv3440 CNV Insertion 18451855
esv22512 CNV Loss 19812545

Relevant External Links for PSMA7 Gene

HapMap Linkage Disequilibrium report
PSMA7
Human Gene Mutation Database (HGMD)
PSMA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA7 Gene

Disorders for PSMA7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for PSMA7 Gene including...

Search for PSMA7 Gene in MalaCards »

Relevant External Links for PSMA7

Genetic Association Database (GAD)
PSMA7
Human Genome Epidemiology (HuGE) Navigator
PSMA7
genes like me logo Genes that share disorders with PSMA7: view

No data available for UniProtKB/Swiss-Prot for PSMA7 Gene

Publications for PSMA7 Gene

  1. Proteasome complex as a potential cellular target of hepatitis B virus X protein. (PMID: 8764072) Huang J. … Liang T.J. (J. Virol. 1996) 2 3 4
  2. Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. (PMID: 11389899) Cho S. … Ryu S.E. (FEBS Lett. 2001) 3 4 23
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation. (PMID: 11713272) Kruger M. … Wong-Staal F. (Mol. Cell. Biol. 2001) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for PSMA7 Gene

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