PSMA7 Gene
protein-coding GIFtS: 67
GCID: GC20M060711
|
|
proteasome (prosome, macropain) subunit, alpha type, 7
| |
Aliases
for PSMA7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Proteasome (Prosome, Macropain) Subunit, Alpha Type, 71 2 | | Proteasome Subunit RC6-12 3 | | HSPC1 2 3 | | Proteasome Subunit XAPC72 3 | | C61 2 | | EC 3.4.25.13 8 | | RC6-11 2 | | Proteasome Subunit Alpha 42 | | XAPC71 2 | | Proteasome Subunit Alpha Type-72 |
Export aliases for PSMA7 gene to outside databasesPrevious GC identifers: GC20M060475 GC20M061350 GC20M061397 GC20M060145 GC20M057489 |
Summaries
for PSMA7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PSMA7:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composedof 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryoticcells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded proteininteracts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosomeentry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in thecellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on thelong arm of chromosome 9. (provided by RefSeq, Jul 2012)
UniProtKB/Swiss-Prot: PSA7_HUMAN, O14818Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleavepeptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Theproteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferationor cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis.Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viralreplication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under bothnormoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1Adegradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediatedtranslation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediatedtransactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response
Gene Wiki entry for PSMA7
|
Genomic Views
for PSMA7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PSMA7 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for PSMA7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMA7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33PSMA7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M060711: view genomic region
(about GC identifiers)
Start:
|
60,711,791 bp from pter |
End:
|
60,718,496 bp from pter |
Size:
|
6,706 bases |
Orientation:
|
minus strand |
|
Proteins
for PSMA7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PSA7_HUMAN, O14818 (See
protein sequence)Recommended Name: Proteasome subunit alpha type-7 Size: 248 amino acids; 27887 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome coreis composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The twoend rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.The catalytic chamber with the active sites is on the inside of the barrel. PSMA7 interacts directly with thePSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Interacts with HIV-1 TAT protein. Interacts withhepatitis B virus X protein (HBX). Interacts with HIF1A. Interacts with RAB7A. Interacts with PARK2. Interacts withABL1 and ABL2. Interacts with EMAP2. Interacts with MAVS
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B2R515 Q9BR53 Q9H4K5 Q9UEU8Alternative splicing: 3 isoforms: O14818-1 O14818-2 O14818-4 Explore the universe of human proteins at neXtProt for PSMA7: NX_O14818
Post-translational modifications:
Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14818
4/15 DME Specific Peptides for PSMA7 (O14818) (see all 15)
PSMA7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002783.1
ENSEMBL proteins: ENSP00000359910 ENSP00000397047 ENSP00000359898 ENSP00000359895 Reactome Protein details: O14818
Human Recombinant Protein Products for PSMA7:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
PSMA7 for ontologies About GeneDecksing
PSMA7 Antibody Products:
Assay Products for PSMA7: |
Protein
Domains /
Families
for PSMA7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PSMA7 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14818ProtoNet protein and cluster: O14818 1 Blocks protein family: IPB000426 Proteasome subunit
UniProtKB/Swiss-Prot: PSA7_HUMAN, O14818Similarity: Belongs to the peptidase T1A family |
Function
for PSMA7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PSA7_HUMAN, O14818Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleavepeptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Theproteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferationor cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis.Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viralreplication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under bothnormoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1Adegradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediatedtranslation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediatedtransactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune responseCatalytic activity: Cleavage of peptide bonds with very broad specificityInduction: Down-regulated by the ribozyme Rz3'X. Up-regulated in colorectal cancer tissues Enzyme Number (IUBMB): EC 3.4.25.11 2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
PSMA7 for ontologies About GeneDecksing
Phenotypes:
5 GenomeRNAi human phenotypes for PSMA7:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMA7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMA7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PSMA7 (NM_002792) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PSMA7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMA7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMA7 |
|
Pathways & Interactions
for PSMA7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitinated Orc1 is degraded by the proteasome | | | 2 | M Phase | | | 3 | Chks in Checkpoint Regulation | | | 4 | HIV Infection | | | 5 | Regulation of degradation of wt-CFTR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for PSMA7
5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMA7 (see all 18)
4  GeneGo (Thomson Reuters) Pathways for PSMA7
1  BioSystems Pathway for PSMA7
5/98 
Reactome Pathways for PSMA7 (see all 98)
1 
Kegg Pathway (Kegg details for PSMA7):
PSMA7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMA7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/283 Interacting proteins for PSMA7 (O148181, 2, 3 ENSP000003599104) via UniProtKB, MINT, STRING, and/or I2D (see all 283)About this table
Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000075 | cell cycle checkpoint |
TAS | -- | | GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000084 | S phase of mitotic cell cycle |
TAS | -- | | GO:0000209 | protein polyubiquitination |
TAS | -- | | GO:0000216 | M/G1 transition of mitotic cell cycle |
TAS | -- |
PSMA7 for ontologies About GeneDecksing
|
Drugs & Compounds
for PSMA7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PSMA7
3 DrugBank Compounds for PSMA7 About this table
Search CenterWatch for drugs/clinical trials and news about PSMA7 / PSA7
|
Transcripts
for PSMA7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PSMA7 gene (2 alternative transcripts): NM_002792.3 NM_152255.1 Unigene Cluster for PSMA7: Proteasome (prosome, macropain) subunit, alpha type, 7 Hs.233952 [show with all ESTs]Unigene Representative Sequence: BF2177556 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370873(uc002ybx.1) ENST00000442551 ENST00000484488 ENST00000370861
ENST00000486193 ENST00000370858
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMA7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMA7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PSMA7 (NM_002792) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PSMA7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMA7 |
Additional cDNA sequence: AF022815.1 AF054185.1 AK312025.1 BC001895.1 BC004427.1 BC014999.1 BT007165.1 24 DOTS entries: DT.91775307 DT.100677049 DT.100839828 DT.92414845 DT.97838342 DT.100677043 DT.100847712 DT.100054664 DT.100060044 DT.95378804 DT.97838362 DT.100060050 DT.100051468 DT.100060040 DT.100060046 DT.100677041 DT.91775310 DT.91843012 DT.91939431 DT.91958119 DT.95216996 DT.97838375 DT.100687117 DT.121636752 24/760 AceView cDNA sequences (see all 760): AA312575 CR624293 BQ021644 CR611945 AA953064 CR616396 BI858508 AA442637 AI292198 CA310432 BQ894035 AI685499 AI874409 AA991383 BQ776162 BU674237 BU632089 AA190632 AA477620 CR600945 BU663462 CA424426 AI088015 CR596694
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PSMA7 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | - | | | | | | - | | - | | | | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for PSMA7
|
Expression
for PSMA7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PSMA7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGAGTCTC
About this image
See PSMA7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSMA7
SOURCE GeneReport for Unigene cluster: Hs.233952
SABiosciences Custom PCR Arrays for PSMA7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSMA7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PSMA7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMA7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMA7 |
Orthologs
for PSMA7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PSMA7 gene from 9/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Psma71 , 5 |
proteasome (prosome, macropain) subunit, alpha type more1, 5 |
90.86(n)1
98.79(a)1 |
|
2 (102.55 cM)5
264441 NM_011969.11 NP_036099.11
1800363735 |
chicken
(Gallus gallus) |
Aves |
PSMA71 |
proteasome (prosome, macropain) subunit, alpha type, more |
83.33(n)
96.37(a) |
|
395318 NM_204613.1 NP_989944.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PSMA76 |
-- |
97(a) |
1 ↔ 1 |
4(150629830-150637954) |
African clawed frog
(Xenopus laevis) |
Amphibia |
AB027463.12 |
-- |
79.78(n) |
|
AB027463.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
psma86 |
proteasome (prosome, macropain) subunit, alpha typ... |
88(a) |
1 → many |
20(18352041-18359752) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pros28.13 |
ATP-dependent proteolysis proteasome
endopeptidase |
68(a)
(best of 3) |
|
14B3 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
pas-46 |
Proteasome subunit alpha type-7 |
60(a) |
1 → many |
I(8727208-8728528) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PAD16PAD26 |
proteasome subunit alpha type-7-B |
66(a)65(a) |
many ↔ manymany ↔ many |
3(19030995-19033064) 5(26437170-26438764) |
rice
(Oryza sativa) |
Liliopsida |
AK098875.12 |
-- |
79.22(n) |
|
AK098875.1 |
ENSEMBL Gene Tree for PSMA7 (if available)
TreeFam Gene Tree for PSMA7 (if available) |
Paralogs
for PSMA7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PSMA7 gene
- PSMA82
8 SIMAP similar genes for PSMA7 using alignment to 4 protein entries: PSA7_HUMAN (see all proteins):PSMA8 DKFZp686D09174 PSMA5 PSMA2 PSMA1 PSMA4
PSMA6 PSMA3
PSMA7 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PSMA7
PGOHUM00000236715
|
Genomic Variants
for PSMA7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PSMA7 (60711791 - 60718496 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PSMA7
1 CNV: 73562 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSMA7 |
|
Disorders
/ Diseases
for PSMA7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PSMA7 for disorders About GeneDecksing
OMIM gene information: 606607
OMIM disorders: --
13  diseases for PSMA7: About MalaCardshepatitis c hepatitis b hepatitis hypoxia
glaucoma colorectal cancer prostate cancer prostatitis
immunodeficiency malaria huntington's disease parkinson's disease
retinoblastoma
Human Genome Epidemiology (HuGE) Navigator: PSMA7 (1 document)
Export disorders for PSMA7 gene to outside databases
|
Publications
for PSMA7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PSMA7 gene, integrated from 9 sources (see all 116):
(articles sorted by number of sources associating them with PSMA7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Proteasome complex as a potential cellular target of hepatitis B virus X protein. (PubMed id 8764072)1, 2, 3 Huang J.... Liang T.J. (1996)
- Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. (PubMed id 11389899)1, 2, 9 Cho S....Ryu S.E. (2001)
- Negative regulation of MAVS-mediated innate immune response by PSMA7. (PubMed id 19734229)1, 2 Jia Y.... Zhong H. (2009)
- Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. (PubMed id 19362550)1, 2 Tandle A.T....Libutti S.K. (2009)
- PSMA7, a potential biomarker of diseases. (PubMed id 19442227)1, 2 Du H.... Li M. (2009)
- The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer. (PubMed id 18202793)1, 2 Hu X.T....He C. (2008)
- Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. (PubMed id 16678104)1, 2 Liu X....Cao C. (2006)
- Parkin interacts with the proteasome subunit alpha4. (PubMed id 15987638)1, 2 Dachsel J.C....Gasser T. (2005)
- A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. (PubMed id 16251969)1, 2 Hirano Y.... Murata S. (2005)
- The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes. (PubMed id 14998988)1, 2 Dong J.... Wandinger-Ness A. (2004)
|
External Searches for PSMA7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PSMA7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PSMA7 gene
(According to HUGE)
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Specialized Databases showing PSMA7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for PSMA7 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for PSMA7 gene:
Search GeneIP for patents involving PSMA7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PSMA7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for PSMA7 | | OriGene shRNA RFP for PSMA7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSMA7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSMA7 | | | OriGene Protein Over-expression Lysate for PSMA7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PSMA7 | | OriGene 3'-UTR Clone for PSMA7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMA7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMA7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PSMA7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PSMA7 | | OriGene Custom Protein Services for PSMA7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PSMA7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSMA7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMA7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMA7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMA7 |
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| | | | Search Tocris compounds for PSMA7 |
| |  |  |  |  | | | | | | Recombinant Protein for PSMA7 |
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 | | | PSMA7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMA7 |
|  |  |  |  | | | | ThermoFisher Antibody for PSMA7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMA7 |
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