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PSMA7 Gene

protein-coding   GIFtS: 69
GCID: GC20M060711

Proteasome (Prosome, Macropain) Subunit, Alpha Type, 7

  See PSMA7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteasome (Prosome, Macropain) Subunit, Alpha Type, 71 2     C62
Proteasome Subunit RC6-11 2 3     RC6-12
Proteasome Subunit XAPC71 2 3     XAPC72
HSPC2 3     Proteasome Subunit Alpha 42
EC 3.4.25.13 8     Proteasome Subunit Alpha Type-72

External Ids:    HGNC: 95361   Entrez Gene: 56882   Ensembl: ENSG000001011827   OMIM: 6066075   UniProtKB: O148183   

Export aliases for PSMA7 gene to outside databases

Previous GC identifers: GC20M060475 GC20M061350 GC20M061397 GC20M060145 GC20M057489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSMA7 Gene:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes,
a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout
eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a
non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha
subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating
hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The
encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha.
A pseudogene of this gene is located on the long arm of chromosome 9. (provided by RefSeq, Jul 2012)

GeneCards Summary for PSMA7 Gene:
PSMA7 (proteasome (prosome, macropain) subunit, alpha type, 7) is a protein-coding gene. Diseases associated with PSMA7 include hepatitis b, and hepatitis c. GO annotations related to this gene include threonine-type endopeptidase activity and identical protein binding. An important paralog of this gene is PSMA8.

UniProtKB/Swiss-Prot: PSA7_HUMAN, O14818
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell
proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell
differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor
regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the
transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with
EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in
hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the
androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and
thereby negatively regulates MAVS-mediated innate immune response

Gene Wiki entry for PSMA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSMA7 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMA7 promoter sequence
   Search Chromatin IP Primers for PSMA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

PSMA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMA7 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M060711:  view genomic region     (about GC identifiers)

Start:
60,711,791 bp from pter      End:
60,718,496 bp from pter
Size:
6,706 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PSA7_HUMAN, O14818 (See protein sequence)
Recommended Name: Proteasome subunit alpha type-7  
Size: 248 amino acids; 27887 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome
core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure.
The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven
beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA7 interacts
directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Interacts with HIV-1 TAT
protein. Interacts with hepatitis B virus X protein (HBX). Interacts with HIF1A. Interacts with RAB7A. Interacts
with PARK2. Interacts with ABL1 and ABL2. Interacts with EMAP2. Interacts with MAVS
Secondary accessions: B2R515 Q5JXJ2 Q9BR53 Q9H4K5 Q9UEU8
Alternative splicing: 3 isoforms:  O14818-1   O14818-2   O14818-4   

Explore the universe of human proteins at neXtProt for PSMA7: NX_O14818

Explore proteomics data for PSMA7 at MOPED

Post-translational modifications: 

  • Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks1
  • Ubiquitination2 at Lys52, Lys61, Lys115, Lys157, Lys174, Lys204, Lys218, Lys227
  • Glycosylation2 at Ser130
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PSMA7 (O14818) (see all 15)
     RARVECQ  RTVRKIC  EKKKQKK  LFQVEYA 


    See PSMA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002783.1  
    ENSEMBL proteins: 
     ENSP00000397047   ENSP00000359910   ENSP00000359898   ENSP00000359895  
    Reactome Protein details: O14818

    PSMA7 Human Recombinant Protein Products:

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    OriGene MassSpec for PSMA7
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    Novus Biologicals PSMA7 Proteins
    Novus Biologicals PSMA7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PSMA7
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PSMA7 

    PSMA7 Antibody Products:

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    Abcam antibodies for PSMA7 (O14818, Q8TAA3, P18421)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PSMA7
    LSBio Antibodies in human, mouse, rat for PSMA7

    PSMA7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PSMA7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PSM: Proteasome (prosome, macropain) subunits

    3 InterPro protein domains:
     IPR001353 Proteasome_sua/b
     IPR000426 Proteasome_asu_N
     IPR023332 Proteasome_suA-type

    Graphical View of Domain Structure for InterPro Entry O14818

    ProtoNet protein and cluster: O14818

    1 Blocks protein domain: IPB000426 Proteasome subunit

    UniProtKB/Swiss-Prot: PSA7_HUMAN, O14818
    Similarity: Belongs to the peptidase T1A family


    Find genes that share domains with PSMA7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSA7_HUMAN, O14818
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell
    proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell
    differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor
    regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the
    transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with
    EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in
    hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the
    androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and
    thereby negatively regulates MAVS-mediated innate immune response
    Catalytic activity: Cleavage of peptide bonds with very broad specificity
    Induction: Down-regulated by the ribozyme Rz3'X. Up-regulated in colorectal cancer tissues

         Enzyme Number (IUBMB): EC 3.4.25.11 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity ----
    GO:0004298threonine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI12376572
    GO:0042802identical protein binding IPI15225636
         
    Find genes that share ontologies with PSMA7           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for PSMA7:
     Decreased viability with pacli  G2 arrest  Increased G2M DNA content  Increased gamma-H2AX phosphory 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSMA7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PSMA7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSMA7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSMA7

    miRNA
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    miRTarBase miRNAs that target PSMA7:
    hsa-mir-92b-3p (MIRT040706), hsa-mir-193b-3p (MIRT041274), hsa-mir-92a-3p (MIRT049617)

    Block miRNA regulation of human, mouse, rat PSMA7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PSMA7
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PSMA7

    Gene Editing
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    Clone
    Products:
         
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PSMA7 (NM_002792)
    Sino Biological Human cDNA Clone for PSMA7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMA7

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMA7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSA7_HUMAN, O14818: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005839proteasome core complex ISS--
    GO:0019773proteasome core complex, alpha-subunit complex IEA--

    Find genes that share ontologies with PSMA7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSMA7 About   (see all 27)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    3Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with PSMA7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSMA7 (see all 18)
        CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    p53 Signaling
    DNA Repair Mechanisms

    4 GeneGo (Thomson Reuters) Pathways for PSMA7
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR

    1 BioSystems Pathway for PSMA7
        Proteasome Degradation


    Selected Reactome Pathways for PSMA7 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    1 Kegg Pathway  (Kegg details for PSMA7):
        Proteasome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSMA7
    Interactions:

        GeneGlobe Interaction Network for PSMA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSMA7 (O148181, 2, 3 ENSP000003599104) via UniProtKB, MINT, STRING, and/or I2D (see all 334)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMA1P257861, 2, 3EBI-603272,EBI-359352 MINT-6176052 MINT-51353 MINT-4050722 MINT-6176676 MINT-51341 MINT-6176430 MINT-51366 MINT-51332 MINT-6176080 I2D: score=9 
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    Find genes that share ontologies with PSMA7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for PSMA7 (PSA7)

    3 DrugBank Compounds for PSMA7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE-- --target--10592235
    2-ACETYLAMINO-4-METHYL-PENTANOIC ACID [1-(1-FORMYL-PENTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDE-- --target--10592235
    N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSMA7 gene (2 alternative transcripts): 
    NM_002792.3  NM_152255.1  

    Unigene Cluster for PSMA7:

    Proteasome (prosome, macropain) subunit, alpha type, 7
    Hs.233952  [show with all ESTs]
    Unigene Representative Sequence: BF217755
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442551 ENST00000370873(uc002ybx.1) ENST00000484488 ENST00000370861
    ENST00000486193 ENST00000370858
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PSMA7
      QuantiFast Probe-based Assays in human, mouse, rat PSMA7

    Additional mRNA sequence: 

    AF022815.1 AF054185.1 AK312025.1 BC001895.1 BC004427.1 BC014999.1 BT007165.1 

    24 DOTS entries:

    DT.91775307  DT.100677049  DT.100839828  DT.92414845  DT.97838342  DT.100677043  DT.100847712  DT.100054664 
    DT.100060044  DT.95378804  DT.97838362  DT.100060050  DT.100051468  DT.100060040  DT.100060046  DT.100677041 
    DT.91775310  DT.91843012  DT.91939431  DT.91958119  DT.95216996  DT.97838375  DT.100687117  DT.121636752 

    Selected AceView cDNA sequences (see all 760):

    AA459678 BM723703 BM823865 BU685988 AI240262 AA442637 AI292198 BQ776162 
    CA310432 AI685499 BQ671646 CR618955 BI906714 BQ010685 NM_152255 BE745021 
    BE407483 CR621598 CB117337 BI858508 AA953064 CR616396 CR611945 BQ021644 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PSMA7 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                          -     -           -                 -     -                       -                       -         
    SP2:                          -     -           -           -     -     -     -                 -                                 
    SP3:                          -     -           -                       -                                                         
    SP4:                                -           -                 -     -                                                         
    SP5:                                            -                       -                       -                                 


    ECgene alternative splicing isoforms for PSMA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSMA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAGTCTC
    PSMA7 Expression
    About this image


    PSMA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    PSMA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSMA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.233952
        Custom PCR Arrays for PSMA7
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMA7 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psma71 , 5 proteasome (prosome, macropain) subunit, alpha type more1, 5 90.86(n)1
    98.79(a)1
      2 (102.55 cM)5
    264441  NM_011969.11  NP_036099.11 
     1800363735 
    chicken
    (Gallus gallus)
    Aves PSMA71 proteasome (prosome, macropain) subunit, alpha type, more 83.04(n)
    96.52(a)
      395318  NM_204613.1  NP_989944.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMA76
    proteasome (prosome, macropain) subunit, alpha typ...
    97(a)
    1 ↔ 1
    4(150627910-150638162)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB027463.12   -- 79.78(n)    AB027463.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.28132 Oncorhynchus mykiss transcribed sequence with strong more 79.28(n)    BX881750.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pros28.13 ATP-dependent proteolysis proteasome
    endopeptidase
    68(a)
    (best of 3)
      14B3   --
    worm
    (Caenorhabditis elegans)
    Secernentea pas-41 pas-4 61.16(n)
    65.62(a)
      172679  NM_059959.4  NP_492360.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRE6(YOL038W)4 Alpha 4 subunit of the 20S proteasome; may replace more   --   15(255337-256101) 854119  NP_014604.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.25872 Transcribed sequence with strong similarity to protein more 75.14(n)    BI469378.1 
    rice
    (Oryza sativa)
    Liliopsida AK098875.12   -- 79.22(n)    AK098875.1 


    ENSEMBL Gene Tree for PSMA7 (if available)
    TreeFam Gene Tree for PSMA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSMA7 gene
    PSMA82  
    8 SIMAP similar genes for PSMA7 using alignment to 3 protein entries:     PSA7_HUMAN (see all proteins):
    PSMA8    DKFZp686D09174    PSMA5    PSMA2    PSMA4    PSMA1
    PSMA6    PSMA3

    Find genes that share paralogs with PSMA7           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PSMA7
    PGOHUM00000236715


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSMA7 (see all 187)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106674521,2
    C--60711298(+) GACCA-/GAGGAGGA 1 -- cds10--------
    rs339642621,2
    C--60711299(+) ACCAG-/GAGAGGAC 1 -- cds10--------
    rs353135781,2
    C--60711300(+) GAGGA-/GGACCCAA 1 -- cds10--------
    rs1464345881,2
    --60711320(+) TAAACG/TGTGGG 1 -- ds50010--------
    rs1478983911,2
    --60711330(+) GACTAC/GAAGTC 1 -- ds50010--------
    rs1828383721,2
    --60711337(+) AGTCAA/CAACAC 1 -- ds50010--------
    rs1416983811,2
    --60711408(+) GGTCTA/GTGAAA 1 -- ds50010--------
    rs1504541431,2
    --60711488(+) GTGTCC/GTTGAC 1 -- ds50010--------
    rs1871229121,2
    --60711621(+) TCTGAA/CTTCCC 1 -- ds50010--------
    rs61219051,2
    H--60711629(+) CCCAAG/AGGAGG 1 -- ds50014Minor allele frequency- A:0.00NS EA 412

    HapMap Linkage Disequilibrium report for PSMA7 (60711791 - 60718496 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PSMA7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1006840CNV Deletion20482838
    nsv509782CNV Insertion20534489
    nsv3440CNV Insertion18451855
    esv22512CNV Loss19812545
    nsv913033CNV Loss21882294
    dgv4597n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): PSMA7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSMA7
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMA7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606607    OMIM disorders: --

    5 diseases for PSMA7:    
    About MalaCards
    hepatitis b    hepatitis c    hepatitis c virus    hepatitis
    hypoxia


    Find genes that share disorders with PSMA7           About GenesLikeMe

    Genetic Association Database (GAD): PSMA7
    Human Genome Epidemiology (HuGE) Navigator: PSMA7 (1 document)

    Export disorders for PSMA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSMA7 gene, integrated from 10 sources (see all 130):
    (articles sorted by number of sources associating them with PSMA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteasome complex as a potential cellular target of hepatitis B virus X protein. (PubMed id 8764072)1, 2, 3 Huang J.... Liang T.J. (J. Virol. 1996)
    2. Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. (PubMed id 11389899)1, 2, 9 Cho S.... Ryu S.E. (FEBS Lett. 2001)
    3. Negative regulation of MAVS-mediated innate immune response by PSMA7. (PubMed id 19734229)1, 2 Jia Y.... Zhong H. (J. Immunol. 2009)
    4. PSMA7, a potential biomarker of diseases. (PubMed id 19442227)1, 2 Du H.... Li M. (Protein Pept. Lett. 2009)
    5. Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. (PubMed id 19362550)1, 2 Tandle A.T....Libutti S.K. (Exp. Cell Res. 2009)
    6. The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer. (PubMed id 18202793)1, 2 Hu X.T....He C. (Oncol. Rep. 2008)
    7. Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. (PubMed id 16678104)1, 2 Liu X....Cao C. (Mol. Cell 2006)
    8. Parkin interacts with the proteasome subunit alpha4. (PubMed id 15987638)1, 2 Dachsel J.C.... Gasser T. (FEBS Lett. 2005)
    9. A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. (PubMed id 16251969)1, 2 Hirano Y.... Murata S. (Nature 2005)
    10. The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes. (PubMed id 14998988)1, 2 Dong J.... Wandinger-Ness A. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5688 HGNC: 9536 AceView: PSMA7 Ensembl:ENSG00000101182 euGenes: HUgn5688
    ECgene: PSMA7 Kegg: 5688 H-InvDB: PSMA7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSMA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSMA7 gene:
    Search GeneIP for patents involving PSMA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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