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Aliases for PSMA7 Gene

Aliases for PSMA7 Gene

  • Proteasome Subunit Alpha 7 2 3 5
  • Proteasome Subunit XAPC7 2 3 4
  • Proteasome Subunit RC6-1 2 3 4
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 7 2 3
  • EC 3.4.25.1 4 63
  • HSPC 3 4
  • Epididymis Secretory Protein Li 276 3
  • Testicular Tissue Protein Li 151 3
  • Proteasome Subunit Alpha 4 3
  • HEL-S-276 3
  • RC6-1 3
  • XAPC7 3
  • C6 3

External Ids for PSMA7 Gene

Previous GeneCards Identifiers for PSMA7 Gene

  • GC20M060475
  • GC20M061350
  • GC20M061397
  • GC20M060145
  • GC20M060711
  • GC20M057489

Summaries for PSMA7 Gene

Entrez Gene Summary for PSMA7 Gene

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSMA7 Gene

PSMA7 (Proteasome Subunit Alpha 7) is a Protein Coding gene. Diseases associated with PSMA7 include hepatitis c virus and hepatitis. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Beta-Adrenergic Signaling. GO annotations related to this gene include identical protein binding and threonine-type endopeptidase activity. An important paralog of this gene is PSMA8.

UniProtKB/Swiss-Prot for PSMA7 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Gene Wiki entry for PSMA7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA7 Gene

Genomics for PSMA7 Gene

Regulatory Elements for PSMA7 Gene

Enhancers for PSMA7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMA7 on UCSC Golden Path with GeneCards custom track

Promoters for PSMA7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMA7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMA7 Gene

Chromosome:
20
Start:
62,136,727 bp from pter
End:
62,143,458 bp from pter
Size:
6,732 bases
Orientation:
Minus strand

Genomic View for PSMA7 Gene

Genes around PSMA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA7 Gene

Proteins for PSMA7 Gene

  • Protein details for PSMA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14818-PSA7_HUMAN
    Recommended name:
    Proteasome subunit alpha type-7
    Protein Accession:
    O14818
    Secondary Accessions:
    • B2R515
    • Q5JXJ2
    • Q9BR53
    • Q9H4K5
    • Q9UEU8

    Protein attributes for PSMA7 Gene

    Size:
    248 amino acids
    Molecular mass:
    27887 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Interacts with HIV-1 TAT protein. Interacts with hepatitis B virus X protein (HBX). Interacts with HIF1A. Interacts with RAB7A. Interacts with PARK2. Interacts with ABL1 and ABL2. Interacts with EMAP2. Interacts with MAVS.

    Three dimensional structures from OCA and Proteopedia for PSMA7 Gene

    Alternative splice isoforms for PSMA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA7 Gene

Proteomics data for PSMA7 Gene at MOPED

Post-translational modifications for PSMA7 Gene

  • Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks.
  • Ubiquitination at Lys 61, Lys 115, Lys 174, Lys 204, Lys 218, and Lys 227
  • Glycosylation at Ser 130
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA7 Gene

Domains & Families for PSMA7 Gene

Gene Families for PSMA7 Gene

Protein Domains for PSMA7 Gene

Graphical View of Domain Structure for InterPro Entry

O14818

UniProtKB/Swiss-Prot:

PSA7_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA7: view

Function for PSMA7 Gene

Molecular function for PSMA7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
UniProtKB/Swiss-Prot Induction:
Down-regulated by the ribozyme Rz3X. Up-regulated in colorectal cancer tissues.

Enzyme Numbers (IUBMB) for PSMA7 Gene

genes like me logo Genes that share phenotypes with PSMA7: view

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA7 Gene

Localization for PSMA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA7 Gene COMPARTMENTS Subcellular localization image for PSMA7 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PSMA7: view

Pathways & Interactions for PSMA7 Gene

SuperPathways for PSMA7 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMA7: view

SIGNOR curated interactions for PSMA7 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PSMA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMA7: view

Drugs & Compounds for PSMA7 Gene

(4) Drugs for PSMA7 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
2-ACETYLAMINO-4-METHYL-PENTANOIC ACID [1-(1-FORMYL-PENTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA7: view

Transcripts for PSMA7 Gene

Unigene Clusters for PSMA7 Gene

Proteasome (prosome, macropain) subunit, alpha type, 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7:
SP8: - -
SP9: -

Relevant External Links for PSMA7 Gene

GeneLoc Exon Structure for
PSMA7
ECgene alternative splicing isoforms for
PSMA7

Expression for PSMA7 Gene

mRNA expression in normal human tissues for PSMA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSMA7 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for PSMA7 Gene

This gene is overexpressed in Liver, secretome (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMA7 Gene



SOURCE GeneReport for Unigene cluster for PSMA7 Gene Hs.233952

genes like me logo Genes that share expression patterns with PSMA7: view

Protein tissue co-expression partners for PSMA7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PSMA7 Gene

Orthologs for PSMA7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMA7 35
  • 93.15 (n)
  • 99.19 (a)
PSMA7 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMA7 35
  • 92.28 (n)
  • 99.07 (a)
PSMA7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psma7 35
  • 90.86 (n)
  • 98.79 (a)
Psma7 16
Psma7 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMA7 35
  • 99.46 (n)
  • 99.6 (a)
PSMA7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psma7 35
  • 91.4 (n)
  • 98.79 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA7 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMA7 35
  • 83.04 (n)
  • 96.52 (a)
PSMA7 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMA7 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75728 35
psma7 35
  • 79.13 (n)
  • 96.96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2813 35
fruit fly
(Drosophila melanogaster)
Insecta Pros28.1 37
  • 68 (a)
Pros28.1A 37
  • 59 (a)
Pros28.1B 37
  • 53 (a)
Pros28.1 36
  • 68 (a)
ManyToMany
Pros28.1A 36
  • 58 (a)
ManyToMany
Pros28.1B 36
  • 50 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pas-4 35
  • 61.16 (n)
  • 65.62 (a)
pas-4 36
  • 60 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE6 36
  • 56 (a)
OneToMany
PRE6 38
soybean
(Glycine max)
eudicotyledons Gma.2587 35
barley
(Hordeum vulgare)
Liliopsida Hv.3003 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4812 36
  • 76 (a)
OneToMany
Species with no ortholog for PSMA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PSMA7 Gene

ENSEMBL:
Gene Tree for PSMA7 (if available)
TreeFam:
Gene Tree for PSMA7 (if available)

Paralogs for PSMA7 Gene

Paralogs for PSMA7 Gene

(8) SIMAP similar genes for PSMA7 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PSMA7 Gene

genes like me logo Genes that share paralogs with PSMA7: view

Variants for PSMA7 Gene

Sequence variations from dbSNP and Humsavar for PSMA7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs7076 -- 62,138,255(-) GTGCG(C/T)GAGTT reference, synonymous-codon
rs12041 -- 62,138,227(-) CTGAC(A/G)AAGCC reference, missense
rs1047918 -- 62,137,124(-) CTGCT(A/G)CTGCT intron-variant
rs1047919 -- 62,136,979(-) TGTGG(C/T)TTAGG intron-variant
rs1135961 -- 62,138,276(-) ATAGG(C/G/T)CGGGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PSMA7 Gene

Variant ID Type Subtype PubMed ID
dgv4597n71 CNV Loss 21882294
nsv913033 CNV Loss 21882294
nsv509782 CNV Insertion 20534489
esv1006840 CNV Deletion 20482838
nsv3440 CNV Insertion 18451855
esv22512 CNV Loss 19812545

Variation tolerance for PSMA7 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA7 Gene

HapMap Linkage Disequilibrium report
PSMA7
Human Gene Mutation Database (HGMD)
PSMA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA7 Gene

Disorders for PSMA7 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PSMA7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
hepatitis
  • hepatitis a
hepatitis b
  • chronic hepatitis b
hiv-1
  • aids, slow progression to
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PSMA7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMA7

Genetic Association Database (GAD)
PSMA7
Human Genome Epidemiology (HuGE) Navigator
PSMA7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA7
genes like me logo Genes that share disorders with PSMA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA7 Gene

Publications for PSMA7 Gene

  1. Proteasome complex as a potential cellular target of hepatitis B virus X protein. (PMID: 8764072) Huang J. … Liang T.J. (J. Virol. 1996) 2 3 4 67
  2. Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. (PMID: 11389899) Cho S. … Ryu S.E. (FEBS Lett. 2001) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PSMA7 Gene

Sources for PSMA7 Gene

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