Aliases for PSMA6 Gene
External Ids for PSMA6 Gene
Previous GeneCards Identifiers for PSMA6 Gene
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]
GeneCards Summary for PSMA6 Gene
PSMA6 (Proteasome Subunit Alpha 6) is a Protein Coding gene. Diseases associated with PSMA6 include Myocardial Infarction and Phaeohyphomycosis. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include RNA binding and NF-kappaB binding.
UniProtKB/Swiss-Prot for PSMA6 Gene
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.