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Aliases for PSMA6 Gene

Aliases for PSMA6 Gene

  • Proteasome Subunit Alpha 6 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 6 2 3
  • Multicatalytic Endopeptidase Complex Iota Chain 3 4
  • 27 KDa Prosomal Protein 3 4
  • Proteasome Iota Chain 3 4
  • Macropain Iota Chain 3 4
  • EC 3.4.25.1 4 61
  • PROS-27 3 4
  • PROS27 3 4
  • P27K 3 4
  • Testicular Secretory Protein Li 44 3
  • Proteasome Subunit Alpha Type-6 3
  • Proteasome Subunit Iota 3
  • Macropain Subunit Iota 3
  • Prosomal P27K Protein 3
  • IOTA 3

External Ids for PSMA6 Gene

Previous GeneCards Identifiers for PSMA6 Gene

  • GC14P033139
  • GC14P029548
  • GC14P033751
  • GC14P034832
  • GC14P035761
  • GC14P015875
  • GC14P035747

Summaries for PSMA6 Gene

Entrez Gene Summary for PSMA6 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

GeneCards Summary for PSMA6 Gene

PSMA6 (Proteasome Subunit Alpha 6) is a Protein Coding gene. Diseases associated with PSMA6 include Myocardial Infarction and Phaeohyphomycosis. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include RNA binding and NF-kappaB binding.

UniProtKB/Swiss-Prot for PSMA6 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Gene Wiki entry for PSMA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA6 Gene

Genomics for PSMA6 Gene

Regulatory Elements for PSMA6 Gene

Enhancers for PSMA6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PSMA6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMA6 Gene

Chromosome:
14
Start:
35,278,558 bp from pter
End:
35,317,493 bp from pter
Size:
38,936 bases
Orientation:
Plus strand

Genomic View for PSMA6 Gene

Genes around PSMA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA6 Gene

Proteins for PSMA6 Gene

  • Protein details for PSMA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60900-PSA6_HUMAN
    Recommended name:
    Proteasome subunit alpha type-6
    Protein Accession:
    P60900
    Secondary Accessions:
    • B2R7J9
    • B4DQR4
    • B4DXJ9
    • P34062
    • Q6IB60

    Protein attributes for PSMA6 Gene

    Size:
    246 amino acids
    Molecular mass:
    27399 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with ALKBH4.

    Three dimensional structures from OCA and Proteopedia for PSMA6 Gene

    Alternative splice isoforms for PSMA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA6 Gene

Selected DME Specific Peptides for PSMA6 Gene

Post-translational modifications for PSMA6 Gene

  • Ubiquitination at Lys 30, Lys 45, Lys 55, Lys 59, Lys 102, Lys 104, Lys 116, Lys 164, Lys 171, and Lys 181
  • Glycosylation at Ser 5
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMA6 (PSMA6)

Domains & Families for PSMA6 Gene

Gene Families for PSMA6 Gene

Protein Domains for PSMA6 Gene

Graphical View of Domain Structure for InterPro Entry

P60900

UniProtKB/Swiss-Prot:

PSA6_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA6: view

Function for PSMA6 Gene

Molecular function for PSMA6 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 6,subunit Pros27 (Iota),27.3 kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Enzyme Numbers (IUBMB) for PSMA6 Gene

Gene Ontology (GO) - Molecular Function for PSMA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 7681138
GO:0004175 endopeptidase activity NAS 7681138
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0035639 purine ribonucleoside triphosphate binding NAS 7681138
genes like me logo Genes that share ontologies with PSMA6: view
genes like me logo Genes that share phenotypes with PSMA6: view

Animal Model Products

CRISPR Products

miRNA for PSMA6 Gene

miRTarBase miRNAs that target PSMA6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA6 Gene

Localization for PSMA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA6 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA6 Gene COMPARTMENTS Subcellular localization image for PSMA6 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 2
endosome 2
endoplasmic reticulum 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PSMA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IDA 7681138
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PSMA6: view

Pathways & Interactions for PSMA6 Gene

SuperPathways for PSMA6 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMA6: view

Gene Ontology (GO) - Biological Process for PSMA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSMA6: view

No data available for SIGNOR curated interactions for PSMA6 Gene

Drugs & Compounds for PSMA6 Gene

(3) Drugs for PSMA6 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 783
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA6: view

Transcripts for PSMA6 Gene

Unigene Clusters for PSMA6 Gene

Proteasome (prosome, macropain) subunit, alpha type, 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA6 Gene

No ASD Table

Relevant External Links for PSMA6 Gene

GeneLoc Exon Structure for
PSMA6
ECgene alternative splicing isoforms for
PSMA6

Expression for PSMA6 Gene

mRNA expression in normal human tissues for PSMA6 Gene

mRNA differential expression in normal tissues according to GTEx for PSMA6 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for PSMA6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.8) and Liver, secretome (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMA6 Gene



Protein tissue co-expression partners for PSMA6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMA6 Gene:

PSMA6

SOURCE GeneReport for Unigene cluster for PSMA6 Gene:

Hs.446260
genes like me logo Genes that share expression patterns with PSMA6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PSMA6 Gene

Orthologs for PSMA6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMA6 34
  • 96.34 (n)
  • 100 (a)
PSMA6 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMA6 34
  • 96.61 (n)
  • 99.59 (a)
PSMA6 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psma6 34
  • 93.63 (n)
  • 99.59 (a)
Psma6 16
Psma6 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMA6 34
  • 99.59 (n)
  • 100 (a)
PSMA6 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psma6 34
  • 94.31 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMA6 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA6 35
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMA6 34
  • 86.99 (n)
  • 96.75 (a)
PSMA6 35
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMA6 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76321 34
psma6 34
  • 80.76 (n)
  • 92.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15878 34
zebrafish
(Danio rerio)
Actinopterygii psma6a 34
zgc:92716 34
  • 77.91 (n)
  • 91.06 (a)
psma6a 35
  • 90 (a)
OneToMany
psma6b 35
  • 91 (a)
OneToMany
psma6l 35
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Prosalpha6 36
  • 64 (a)
Prosalpha1 34
  • 60.38 (n)
  • 67.21 (a)
CG30382 35
  • 67 (a)
OneToMany
Prosalpha1 35
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003935 34
  • 64.5 (n)
  • 73.58 (a)
worm
(Caenorhabditis elegans)
Secernentea pas-1 34
  • 56.37 (n)
  • 56.5 (a)
pas-1 35
  • 56 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL089W 34
  • 54.03 (n)
  • 55.42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05027g 34
  • 55.14 (n)
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCL1 34
  • 58.09 (n)
  • 56.02 (a)
SCL1 35
  • 52 (a)
OneToOne
SCL1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons PAA1 34
  • 61.25 (n)
  • 64.23 (a)
soybean
(Glycine max)
eudicotyledons Gma.17539 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7441 34
barley
(Hordeum vulgare)
Liliopsida Hv.6366 34
rice
(Oryza sativa)
Liliopsida Os.3704 34
Os03g0180400 34
  • 60.43 (n)
  • 60.57 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6475 34
corn
(Zea mays)
Liliopsida Zm.3422 34
bread mold
(Neurospora crassa)
Ascomycetes NCU10061 34
  • 57.88 (n)
  • 62.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC646.16 34
  • 59.38 (n)
  • 59.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8137 35
  • 74 (a)
OneToOne
Species where no ortholog for PSMA6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA6 Gene

ENSEMBL:
Gene Tree for PSMA6 (if available)
TreeFam:
Gene Tree for PSMA6 (if available)

Paralogs for PSMA6 Gene

genes like me logo Genes that share paralogs with PSMA6: view

No data available for Paralogs for PSMA6 Gene

Variants for PSMA6 Gene

Sequence variations from dbSNP and Humsavar for PSMA6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs4665 -- 35,313,047(+) TTTGA(A/G)CAGAC intron-variant, reference, synonymous-codon
rs13393 -- 35,314,450(+) CCTAA(A/G)TTCAG nc-transcript-variant, reference, synonymous-codon
rs2415285 -- 35,294,741(+) TCTGT(A/T)TGGAA intron-variant
rs2415286 -- 35,299,402(+) gctgc(A/G)acctc intron-variant
rs7142115 -- 35,281,773(+) TTTTT(A/T)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMA6 Gene

Variant ID Type Subtype PubMed ID
dgv1868n100 CNV gain 25217958
dgv1869n100 CNV gain 25217958
esv2661597 CNV deletion 23128226
esv3584260 CNV gain 25503493
nsv1134369 CNV deletion 24896259
nsv456205 CNV loss 19166990
nsv564318 CNV loss 21841781

Variation tolerance for PSMA6 Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA6 Gene

Human Gene Mutation Database (HGMD)
PSMA6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA6 Gene

Disorders for PSMA6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PSMA6 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
phaeohyphomycosis
  • infection by dematiacious fungi
clostridium difficile colitis
  • pseudomembranous colitis
craniometaphyseal dysplasia
  • craniometaphyseal dysplasia, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards
Search PSMA6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMA6

Genetic Association Database (GAD)
PSMA6
Human Genome Epidemiology (HuGE) Navigator
PSMA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA6
genes like me logo Genes that share disorders with PSMA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA6 Gene

Publications for PSMA6 Gene

  1. The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family. (PMID: 7681138) Bey F. … Scherrer K. (Mol. Gen. Genet. 1993) 3 4 22 65
  2. The primary structures of four subunits of the human, high-molecular- weight proteinase, macropain (proteasome), are distinct but homologous. (PMID: 1888762) DeMartino G.N. … Slaughter C.A. (Biochim. Biophys. Acta 1991) 2 3 4 65
  3. The G-Allele of the PSMA6-8C>G polymorphism is associated with poor outcome in multiple myeloma independently of circulating proteasome serum levels. (PMID: 20408869) Bachmann H.S. … NA1ckel H. (Eur. J. Haematol. 2010) 3 46 65
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  5. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PMID: 20953189) Stuart P.E. … Elder J.T. (Nat. Genet. 2010) 3 46 65

Products for PSMA6 Gene

Sources for PSMA6 Gene

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