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Aliases for PSMA5 Gene

Aliases for PSMA5 Gene

  • Proteasome Subunit Alpha 5 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 5 2 3
  • Multicatalytic Endopeptidase Complex Zeta Chain 3 4
  • Proteasome Zeta Chain 3 4
  • Macropain Zeta Chain 3 4
  • EC 4 63
  • Epididymis Tissue Sperm Binding Protein Li 11n 3
  • Proteasome Alpha 5 Subunit 3
  • Proteasome Subunit Zeta 3
  • Macropain Subunit Zeta 3
  • Proteasome Component 5 3
  • Zeta 3
  • PSC5 3

External Ids for PSMA5 Gene

Previous GeneCards Identifiers for PSMA5 Gene

  • GC01M110423
  • GC01M108873
  • GC01M109046
  • GC01M109243
  • GC01M109656
  • GC01M109944
  • GC01M107837

Summaries for PSMA5 Gene

Entrez Gene Summary for PSMA5 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for PSMA5 Gene

PSMA5 (Proteasome Subunit Alpha 5) is a Protein Coding gene. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMA5 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Gene Wiki entry for PSMA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA5 Gene

Genomics for PSMA5 Gene

Regulatory Elements for PSMA5 Gene

Enhancers for PSMA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMA5 on UCSC Golden Path with GeneCards custom track

Promoters for PSMA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMA5 Gene

109,399,031 bp from pter
109,426,486 bp from pter
27,456 bases
Minus strand

Genomic View for PSMA5 Gene

Genes around PSMA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA5 Gene

Proteins for PSMA5 Gene

  • Protein details for PSMA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proteasome subunit alpha type-5
    Protein Accession:
    Secondary Accessions:
    • B2R8F6
    • B4E2V4
    • Q3T1C1
    • Q6IBF7

    Protein attributes for PSMA5 Gene

    241 amino acids
    Molecular mass:
    26411 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA5 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly.

    Three dimensional structures from OCA and Proteopedia for PSMA5 Gene

    Alternative splice isoforms for PSMA5 Gene


neXtProt entry for PSMA5 Gene

Proteomics data for PSMA5 Gene at MOPED

Post-translational modifications for PSMA5 Gene

  • Ubiquitination at Lys 66, Lys 86, Lys 91, Lys 187, Lys 192, Lys 196, Lys 203, Lys 209, Lys 231, and Lys 239
  • Glycosylation at Ser 198
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA5 Gene

Domains & Families for PSMA5 Gene

Gene Families for PSMA5 Gene

Protein Domains for PSMA5 Gene

Suggested Antigen Peptide Sequences for PSMA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase T1A family.
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA5: view

Function for PSMA5 Gene

Molecular function for PSMA5 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component alpha 5
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in colon cancer cell lines. Up-regulated in fetal Down syndrome (DS) brain (at protein level). May be the target of the transcriptional activator NFE2L2.

Enzyme Numbers (IUBMB) for PSMA5 Gene

genes like me logo Genes that share phenotypes with PSMA5: view

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA5 Gene

Localization for PSMA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for PSMA5 Gene COMPARTMENTS Subcellular localization image for PSMA5 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PSMA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PSMA5: view

Pathways & Interactions for PSMA5 Gene

SuperPathways for PSMA5 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
5 Immune System
genes like me logo Genes that share pathways with PSMA5: view

Gene Ontology (GO) - Biological Process for PSMA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMA5: view

No data available for SIGNOR curated interactions for PSMA5 Gene

Drugs & Compounds for PSMA5 Gene

(3) Drugs for PSMA5 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
genes like me logo Genes that share compounds with PSMA5: view

Transcripts for PSMA5 Gene

Unigene Clusters for PSMA5 Gene

Proteasome (prosome, macropain) subunit, alpha type, 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for PSMA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSMA5 Gene

mRNA expression in normal human tissues for PSMA5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMA5 Gene

SOURCE GeneReport for Unigene cluster for PSMA5 Gene Hs.485246

mRNA Expression by UniProt/SwissProt for PSMA5 Gene

Tissue specificity: Expressed in fetal brain (at protein level).
genes like me logo Genes that share expression patterns with PSMA5: view

Protein tissue co-expression partners for PSMA5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PSMA5 Gene

Orthologs for PSMA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PSMA5 35
  • 95.44 (n)
  • 100 (a)
PSMA5 36
  • 100 (a)
(Canis familiaris)
Mammalia PSMA5 35
  • 95.71 (n)
  • 100 (a)
PSMA5 36
  • 100 (a)
(Mus musculus)
Mammalia Psma5 35
  • 94.19 (n)
  • 100 (a)
Psma5 16
Gm8394 36
  • 98 (a)
Psma5 36
  • 100 (a)
(Pan troglodytes)
Mammalia LOC469795 35
  • 100 (n)
  • 100 (a)
PSMA5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Psma5 35
  • 92.81 (n)
  • 98.76 (a)
(Monodelphis domestica)
Mammalia PSMA5 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia PSMA5 36
  • 96 (a)
(Gallus gallus)
Aves PSMA5 35
  • 82.71 (n)
  • 97.51 (a)
PSMA5 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia psma5 35
  • 80.91 (n)
  • 96.68 (a)
Str.484 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6194 35
(Danio rerio)
Actinopterygii psma5 35
  • 80.08 (n)
  • 96.27 (a)
wufj61e02 35
psma5 36
  • 96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11023 35
fruit fly
(Drosophila melanogaster)
Insecta ProsMA5 37
  • 70 (a)
Prosalpha5 35
  • 65.01 (n)
  • 71.37 (a)
Prosalpha5 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008816 35
  • 61.69 (n)
  • 68.88 (a)
(Caenorhabditis elegans)
Secernentea pas-5 35
  • 60.76 (n)
  • 64.14 (a)
pas-5 36
  • 60 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER296W 35
  • 58.78 (n)
  • 62.24 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05093g 35
  • 58.33 (n)
  • 61.67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP2 35
  • 58.64 (n)
  • 61.41 (a)
PUP2 36
  • 57 (a)
PUP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PAE1 35
  • 67.66 (n)
  • 69.66 (a)
(Glycine max)
eudicotyledons Gma.6014 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7256 35
(Hordeum vulgare)
Liliopsida Hv.5820 35
(Oryza sativa)
Liliopsida Os.3705 35
Os11g0615700 35
  • 65.53 (n)
  • 70.94 (a)
(Triticum aestivum)
Liliopsida Ta.1809 35
(Zea mays)
Liliopsida Zm.16891 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1916 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05295 35
  • 60.78 (n)
  • 64.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pup2 35
  • 60.92 (n)
  • 62.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11003 36
  • 79 (a)
Species with no ortholog for PSMA5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA5 Gene

Gene Tree for PSMA5 (if available)
Gene Tree for PSMA5 (if available)

Paralogs for PSMA5 Gene

(7) SIMAP similar genes for PSMA5 Gene using alignment to 1 proteins: Pseudogenes for PSMA5 Gene

genes like me logo Genes that share paralogs with PSMA5: view

No data available for Paralogs for PSMA5 Gene

Variants for PSMA5 Gene

Sequence variations from dbSNP and Humsavar for PSMA5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1050024 -- 109,426,355(-) GCGTA(C/G)CGCTG intron-variant, utr-variant-5-prime
rs1149174 -- 109,407,985(+) ATAAC(A/G)ACTTT intron-variant
rs1525917 -- 109,412,757(+) AACTA(C/T)GTCCA intron-variant
rs1290168 -- 109,423,182(+) gcctg(C/T)aatcc intron-variant
rs1465607 -- 109,415,413(-) TATGT(A/G)AGACA intron-variant

Variation tolerance for PSMA5 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PSMA5 Gene

Disorders for PSMA5 Gene

Relevant External Links for PSMA5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSMA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMA5 Gene

Publications for PSMA5 Gene

  1. The primary structures of four subunits of the human, high-molecular- weight proteinase, macropain (proteasome), are distinct but homologous. (PMID: 1888762) DeMartino G.N. … Slaughter C.A. (Biochim. Biophys. Acta 1991) 2 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations. (PMID: 26075709) Chang L. … Monteiro M.J. (PLoS ONE 2015) 3

Products for PSMA5 Gene

Sources for PSMA5 Gene