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Aliases for PSMA5 Gene

Aliases for PSMA5 Gene

  • Proteasome Subunit Alpha 5 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 5 2 3
  • Multicatalytic Endopeptidase Complex Zeta Chain 3 4
  • Proteasome Zeta Chain 3 4
  • Macropain Zeta Chain 3 4
  • EC 3.4.25.1 4 61
  • Epididymis Tissue Sperm Binding Protein Li 11n 3
  • Proteasome Subunit Alpha Type-5 3
  • Proteasome Alpha 5 Subunit 3
  • Proteasome Subunit Zeta 3
  • Macropain Subunit Zeta 3
  • Proteasome Component 5 3
  • Zeta 3
  • PSC5 3

External Ids for PSMA5 Gene

Previous GeneCards Identifiers for PSMA5 Gene

  • GC01M110423
  • GC01M108873
  • GC01M109046
  • GC01M109243
  • GC01M109656
  • GC01M109944
  • GC01M107837

Summaries for PSMA5 Gene

Entrez Gene Summary for PSMA5 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for PSMA5 Gene

PSMA5 (Proteasome Subunit Alpha 5) is a Protein Coding gene. Diseases associated with PSMA5 include Down Syndrome. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMA5 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Gene Wiki entry for PSMA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA5 Gene

Genomics for PSMA5 Gene

Regulatory Elements for PSMA5 Gene

Enhancers for PSMA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PSMA5 on UCSC Golden Path with GeneCards custom track

Promoters for PSMA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PSMA5 Gene

Chromosome:
1
Start:
109,399,031 bp from pter
End:
109,426,486 bp from pter
Size:
27,456 bases
Orientation:
Minus strand

Genomic View for PSMA5 Gene

Genes around PSMA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA5 Gene

Proteins for PSMA5 Gene

  • Protein details for PSMA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28066-PSA5_HUMAN
    Recommended name:
    Proteasome subunit alpha type-5
    Protein Accession:
    P28066
    Secondary Accessions:
    • B2R8F6
    • B4E2V4
    • Q3T1C1
    • Q6IBF7

    Protein attributes for PSMA5 Gene

    Size:
    241 amino acids
    Molecular mass:
    26411 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA5 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly.

    Three dimensional structures from OCA and Proteopedia for PSMA5 Gene

    Alternative splice isoforms for PSMA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA5 Gene

Post-translational modifications for PSMA5 Gene

  • Ubiquitination at Lys 66, Lys 86, Lys 91, Lys 187, Lys 192, Lys 196, Lys 203, Lys 209, Lys 231, and Lys 239
  • Glycosylation at Ser 198
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA5 Gene

Domains & Families for PSMA5 Gene

Gene Families for PSMA5 Gene

Protein Domains for PSMA5 Gene

Suggested Antigen Peptide Sequences for PSMA5 Gene

Graphical View of Domain Structure for InterPro Entry

P28066

UniProtKB/Swiss-Prot:

PSA5_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA5: view

Function for PSMA5 Gene

Molecular function for PSMA5 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component alpha 5
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in colon cancer cell lines. Up-regulated in fetal Down syndrome (DS) brain (at protein level). May be the target of the transcriptional activator NFE2L2.

Enzyme Numbers (IUBMB) for PSMA5 Gene

Gene Ontology (GO) - Molecular Function for PSMA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 15225636
genes like me logo Genes that share ontologies with PSMA5: view
genes like me logo Genes that share phenotypes with PSMA5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA5 Gene

Localization for PSMA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA5 Gene COMPARTMENTS Subcellular localization image for PSMA5 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PSMA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMA5: view

Pathways & Interactions for PSMA5 Gene

SuperPathways for PSMA5 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMA5: view

Gene Ontology (GO) - Biological Process for PSMA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSMA5: view

No data available for SIGNOR curated interactions for PSMA5 Gene

Drugs & Compounds for PSMA5 Gene

(3) Drugs for PSMA5 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 783
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA5: view

Transcripts for PSMA5 Gene

Unigene Clusters for PSMA5 Gene

Proteasome (prosome, macropain) subunit, alpha type, 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for PSMA5 Gene

GeneLoc Exon Structure for
PSMA5
ECgene alternative splicing isoforms for
PSMA5

Expression for PSMA5 Gene

mRNA expression in normal human tissues for PSMA5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMA5 Gene



Protein tissue co-expression partners for PSMA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMA5 Gene:

PSMA5

SOURCE GeneReport for Unigene cluster for PSMA5 Gene:

Hs.485246

mRNA Expression by UniProt/SwissProt for PSMA5 Gene:

P28066-PSA5_HUMAN
Tissue specificity: Expressed in fetal brain (at protein level).
genes like me logo Genes that share expression patterns with PSMA5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PSMA5 Gene

Orthologs for PSMA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMA5 34
  • 95.44 (n)
  • 100 (a)
PSMA5 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMA5 34
  • 95.71 (n)
  • 100 (a)
PSMA5 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psma5 34
  • 94.19 (n)
  • 100 (a)
Psma5 16
Gm8394 35
  • 98 (a)
OneToMany
Psma5 35
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC469795 34
  • 100 (n)
  • 100 (a)
PSMA5 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psma5 34
  • 92.81 (n)
  • 98.76 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMA5 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA5 35
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMA5 34
  • 82.71 (n)
  • 97.51 (a)
PSMA5 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psma5 34
  • 80.91 (n)
  • 96.68 (a)
Str.484 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6194 34
zebrafish
(Danio rerio)
Actinopterygii psma5 34
  • 80.08 (n)
  • 96.27 (a)
wufj61e02 34
psma5 35
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11023 34
fruit fly
(Drosophila melanogaster)
Insecta ProsMA5 36
  • 70 (a)
Prosalpha5 34
  • 65.01 (n)
  • 71.37 (a)
Prosalpha5 35
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008816 34
  • 61.69 (n)
  • 68.88 (a)
worm
(Caenorhabditis elegans)
Secernentea pas-5 34
  • 60.76 (n)
  • 64.14 (a)
pas-5 35
  • 60 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER296W 34
  • 58.78 (n)
  • 62.24 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05093g 34
  • 58.33 (n)
  • 61.67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUP2 34
  • 58.64 (n)
  • 61.41 (a)
PUP2 35
  • 57 (a)
OneToOne
PUP2 37
thale cress
(Arabidopsis thaliana)
eudicotyledons PAE1 34
  • 67.66 (n)
  • 69.66 (a)
soybean
(Glycine max)
eudicotyledons Gma.6014 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7256 34
barley
(Hordeum vulgare)
Liliopsida Hv.5820 34
rice
(Oryza sativa)
Liliopsida Os.3705 34
Os11g0615700 34
  • 65.53 (n)
  • 70.94 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1809 34
corn
(Zea mays)
Liliopsida Zm.16891 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1916 34
bread mold
(Neurospora crassa)
Ascomycetes NCU05295 34
  • 60.78 (n)
  • 64.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pup2 34
  • 60.92 (n)
  • 62.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11003 35
  • 79 (a)
OneToOne
Species where no ortholog for PSMA5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA5 Gene

ENSEMBL:
Gene Tree for PSMA5 (if available)
TreeFam:
Gene Tree for PSMA5 (if available)

Paralogs for PSMA5 Gene

(7) SIMAP similar genes for PSMA5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PSMA5 Gene

genes like me logo Genes that share paralogs with PSMA5: view

No data available for Paralogs for PSMA5 Gene

Variants for PSMA5 Gene

Sequence variations from dbSNP and Humsavar for PSMA5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1050024 -- 109,426,355(-) GCGTA(C/G)CGCTG intron-variant, utr-variant-5-prime
rs1149174 -- 109,407,985(+) ATAAC(A/G)ACTTT intron-variant
rs1290168 -- 109,423,182(+) gcctg(C/T)aatcc intron-variant
rs1465607 -- 109,415,413(-) TATGT(A/G)AGACA intron-variant
rs1525917 -- 109,412,757(+) AACTA(C/T)GTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMA5 Gene

Variant ID Type Subtype PubMed ID
dgv252n100 CNV gain 25217958

Variation tolerance for PSMA5 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA5 Gene

Disorders for PSMA5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMA5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
down syndrome
  • complete trisomy 21 syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PSMA5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMA5

Genetic Association Database (GAD)
PSMA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA5
genes like me logo Genes that share disorders with PSMA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA5 Gene

Publications for PSMA5 Gene

  1. The primary structures of four subunits of the human, high-molecular- weight proteinase, macropain (proteasome), are distinct but homologous. (PMID: 1888762) DeMartino G.N. … Slaughter C.A. (Biochim. Biophys. Acta 1991) 2 3 4 65
  2. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3 46 65
  3. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 65
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 65

Products for PSMA5 Gene

Sources for PSMA5 Gene

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