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Aliases for PSMA4 Gene

Aliases for PSMA4 Gene

  • Proteasome Subunit Alpha 4 2 3
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 4 2 3
  • Multicatalytic Endopeptidase Complex Subunit C9 3 4
  • Proteasome Component C9 3 4
  • Macropain Subunit C9 3 4
  • Proteasome Subunit L 3 4
  • EC 3.4.25.1 4 63
  • PSC9 3 4
  • HC9 3 4
  • Proteasome Subunit HC9 3
  • HsT17706 3

External Ids for PSMA4 Gene

Previous GeneCards Identifiers for PSMA4 Gene

  • GC15P074911
  • GC15P071922
  • GC15P076408
  • GC15P076548
  • GC15P076619
  • GC15P078832
  • GC15P055589

Summaries for PSMA4 Gene

Entrez Gene Summary for PSMA4 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMA4 Gene

PSMA4 (Proteasome Subunit Alpha 4) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMA4 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity

Gene Wiki entry for PSMA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA4 Gene

Genomics for PSMA4 Gene

Regulatory Elements for PSMA4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMA4 Gene

Chromosome:
15
Start:
78,540,405 bp from pter
End:
78,552,419 bp from pter
Size:
12,015 bases
Orientation:
Plus strand

Genomic View for PSMA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA4 Gene

Proteins for PSMA4 Gene

  • Protein details for PSMA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25789-PSA4_HUMAN
    Recommended name:
    Proteasome subunit alpha type-4
    Protein Accession:
    P25789
    Secondary Accessions:
    • D3DW86
    • Q53XP2
    • Q567Q5
    • Q8TBD1

    Protein attributes for PSMA4 Gene

    Size:
    261 amino acids
    Molecular mass:
    29484 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interaction with HTLV-1 TAX protein favors NFKB1 activation

    Three dimensional structures from OCA and Proteopedia for PSMA4 Gene

    Alternative splice isoforms for PSMA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA4 Gene

Proteomics data for PSMA4 Gene at MOPED

Post-translational modifications for PSMA4 Gene

  • Ubiquitination at Lys 54, Lys 64, Lys 67, Lys 127, Lys 176, Lys 195, Lys 199, Lys 205, Lys 210, Lys 231, and Lys 238
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for PSMA4 Gene

Gene Families for PSMA4 Gene

Suggested Antigen Peptide Sequences for PSMA4 Gene

Graphical View of Domain Structure for InterPro Entry

P25789

UniProtKB/Swiss-Prot:

PSA4_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA4: view

Function for PSMA4 Gene

Molecular function for PSMA4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
UniProtKB/Swiss-Prot Induction:
Down-regulated by antioxidants BO-653 and probucol.

Enzyme Numbers (IUBMB) for PSMA4 Gene

Gene Ontology (GO) - Molecular Function for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12376572
genes like me logo Genes that share ontologies with PSMA4: view
genes like me logo Genes that share phenotypes with PSMA4: view

miRNA for PSMA4 Gene

miRTarBase miRNAs that target PSMA4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMA4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA4 Gene

Localization for PSMA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA4 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA4 Gene COMPARTMENTS Subcellular localization image for PSMA4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PSMA4: view

Pathways & Interactions for PSMA4 Gene

SuperPathways for PSMA4 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin receptor SHC signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.53
5 Immune System
genes like me logo Genes that share pathways with PSMA4: view

Gene Ontology (GO) - Biological Process for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PSMA4: view

No data available for SIGNOR curated interactions for PSMA4 Gene

Drugs & Compounds for PSMA4 Gene

(3) Drugs for PSMA4 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA4: view

Transcripts for PSMA4 Gene

Unigene Clusters for PSMA4 Gene

Proteasome (prosome, macropain) subunit, alpha type, 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7:
SP8: -

Relevant External Links for PSMA4 Gene

GeneLoc Exon Structure for
PSMA4
ECgene alternative splicing isoforms for
PSMA4

Expression for PSMA4 Gene

mRNA expression in normal human tissues for PSMA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMA4 Gene

This gene is overexpressed in Nasal epithelium (6.3) and Liver, secretome (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMA4 Gene



SOURCE GeneReport for Unigene cluster for PSMA4 Gene Hs.251531

genes like me logo Genes that share expression patterns with PSMA4: view

Protein tissue co-expression partners for PSMA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMA4 Gene

Orthologs for PSMA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMA4 35
  • 95.15 (n)
  • 100 (a)
PSMA4 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psma4 35
  • 91.32 (n)
  • 98.85 (a)
Psma4 16
Psma4 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMA4 35
  • 99.87 (n)
  • 100 (a)
PSMA4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psma4 35
  • 91.83 (n)
  • 99.23 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMA4 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA4 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMA4 35
  • 84.29 (n)
  • 99.23 (a)
PSMA4 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psma4 35
  • 84.39 (n)
  • 97.89 (a)
Str.8679 35
zebrafish
(Danio rerio)
Actinopterygii Dr.10596 35
psma4 35
  • 76.93 (n)
  • 97.05 (a)
psma4 36
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9056 35
fruit fly
(Drosophila melanogaster)
Insecta Pros29 37
  • 72 (a)
Prosalpha3T 37
  • 56 (a)
Pros29 35
  • 63.85 (n)
  • 74.26 (a)
Pros29 36
  • 70 (a)
OneToMany
Prosalpha3T 36
  • 54 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004960 35
  • 65.12 (n)
  • 76.37 (a)
worm
(Caenorhabditis elegans)
Secernentea pas-3 35
  • 60.26 (n)
  • 68.38 (a)
pas-3 36
  • 66 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR318W 35
  • 53.9 (n)
  • 56.6 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03917g 35
  • 55.32 (n)
  • 54.89 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE9 35
  • 56.31 (n)
  • 54.04 (a)
PRE9 36
  • 51 (a)
OneToOne
PRE9 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PAC1 35
  • 61.58 (n)
  • 63.68 (a)
soybean
(Glycine max)
eudicotyledons Gma.3753 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8126 35
rice
(Oryza sativa)
Liliopsida Os06g0176000 35
  • 56.97 (n)
  • 67.27 (a)
corn
(Zea mays)
Liliopsida Zm.6197 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2454 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05942 35
  • 57.06 (n)
  • 63.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC13C5.01c 35
  • 59.46 (n)
  • 54.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.27 36
  • 75 (a)
OneToOne
Species with no ortholog for PSMA4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMA4 Gene

ENSEMBL:
Gene Tree for PSMA4 (if available)
TreeFam:
Gene Tree for PSMA4 (if available)

Paralogs for PSMA4 Gene

Pseudogenes.org Pseudogenes for PSMA4 Gene

genes like me logo Genes that share paralogs with PSMA4: view

No data available for Paralogs for PSMA4 Gene

Variants for PSMA4 Gene

Sequence variations from dbSNP and Humsavar for PSMA4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs8053 -- 78,548,878(+) AAACA(C/T)GAGGA synonymous-codon, reference
rs17588 -- 78,542,191(+) TATGA(C/T)TCCAG reference, synonymous-codon, utr-variant-5-prime
rs1052035 -- 78,549,011(-) TTCCT(A/G)GTGTG utr-variant-3-prime
rs1052040 -- 78,549,139(-) ATTAA(A/G)ACGTC utr-variant-3-prime
rs1065640 -- 78,548,915(-) TTTTT(C/T)TTTCT missense, reference

Variation tolerance for PSMA4 Gene

Residual Variation Intolerance Score: 33.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA4 Gene

HapMap Linkage Disequilibrium report
PSMA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMA4 Gene

Disorders for PSMA4 Gene

Relevant External Links for PSMA4

Genetic Association Database (GAD)
PSMA4
Human Genome Epidemiology (HuGE) Navigator
PSMA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA4
genes like me logo Genes that share disorders with PSMA4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMA4 Gene

Publications for PSMA4 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T. … Ichihara A. (Biochim. Biophys. Acta 1991) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. (PMID: 25101718) Lee J.H. … Silverman E.K. (Am. J. Respir. Cell Mol. Biol. 2015) 67
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 67

Products for PSMA4 Gene

Sources for PSMA4 Gene

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