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Aliases for PSMA4 Gene

Aliases for PSMA4 Gene

  • Proteasome Subunit Alpha 4 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 4 2 3
  • Multicatalytic Endopeptidase Complex Subunit C9 3 4
  • Proteasome Component C9 3 4
  • Macropain Subunit C9 3 4
  • Proteasome Subunit L 3 4
  • EC 3.4.25.1 4 61
  • PSC9 3 4
  • HC9 3 4
  • Proteasome Subunit Alpha Type-4 3
  • Proteasome Subunit HC9 3
  • HsT17706 3

External Ids for PSMA4 Gene

Previous GeneCards Identifiers for PSMA4 Gene

  • GC15P074911
  • GC15P071922
  • GC15P076408
  • GC15P076548
  • GC15P076619
  • GC15P078832
  • GC15P055589

Summaries for PSMA4 Gene

Entrez Gene Summary for PSMA4 Gene

  • This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016]

GeneCards Summary for PSMA4 Gene

PSMA4 (Proteasome Subunit Alpha 4) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMA4 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Gene Wiki entry for PSMA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA4 Gene

Genomics for PSMA4 Gene

Regulatory Elements for PSMA4 Gene

Enhancers for PSMA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F078452 1.1 Ensembl ENCODE 19.9 -85.3 -85252 5.1 PKNOX1 CREB3L1 INSM2 SIN3A FEZF1 ZNF121 ZNF366 SCRT2 CREM ZNF362 PSMA4 IREB2 WDR61 CRABP1 ENSG00000259474
GH15F078539 1.1 ENCODE 14.8 +0.6 601 3.0 HDGF ATF1 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 CHRNA5 PSMA4 HYKK IREB2
GH15F078564 1 ENCODE 13.8 +25.4 25422 2.2 ARID4B SIN3A ELK1 ZNF263 SP3 REST SMARCA4 MXD3 NBN KDM1A CHRNA5 PSMA4 HYKK ADAMTS7 MORF4L1 CRABP1 RASGRF1 ENSG00000261762
GH15F078436 1.1 ENCODE 9.3 -101.6 -101637 4.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CHRNA5 WDR61 IREB2 ENSG00000259562 ENSG00000259322 TBC1D2B HYKK ENSG00000260988 ENSG00000259792 PSMA4
GH15F078447 1.1 Ensembl ENCODE 9.2 -91.1 -91102 3.6 HDGF HDAC1 PKNOX1 FEZF1 RAD21 SCRT2 ZNF143 OVOL3 REST ZNF843 CHRNA5 CRABP1 PSMA4 IREB2 ENSG00000259474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMA4 on UCSC Golden Path with GeneCards custom track

Promoters for PSMA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000022412 595 2400 HDGF ATF1 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2

Genomic Location for PSMA4 Gene

Chromosome:
15
Start:
78,540,405 bp from pter
End:
78,552,419 bp from pter
Size:
12,015 bases
Orientation:
Plus strand

Genomic View for PSMA4 Gene

Genes around PSMA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA4 Gene

Proteins for PSMA4 Gene

  • Protein details for PSMA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25789-PSA4_HUMAN
    Recommended name:
    Proteasome subunit alpha type-4
    Protein Accession:
    P25789
    Secondary Accessions:
    • D3DW86
    • Q53XP2
    • Q567Q5
    • Q8TBD1

    Protein attributes for PSMA4 Gene

    Size:
    261 amino acids
    Molecular mass:
    29484 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interaction with HTLV-1 TAX protein favors NFKB1 activation.

    Three dimensional structures from OCA and Proteopedia for PSMA4 Gene

    Alternative splice isoforms for PSMA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA4 Gene

Selected DME Specific Peptides for PSMA4 Gene

P25789:
  • SDPSGNY
  • TIFSPEGR
  • RPFGVSLL
  • HAGTCLGIL
  • GKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQ
  • GWKATCIG
  • ELRLIAQRY
  • SMLKQDY
  • FSPEGRL
  • VAGITSDAN
  • CDIKQAYTQ
  • KVLNKTMDVSKLSAEKVEIATLTRE

Post-translational modifications for PSMA4 Gene

  • Ubiquitination at Lys 54, Lys 64, Lys 67, Lys 127, Lys 176, Lys 195, Lys 199, Lys 205, Lys 210, Lys 231, and Lys 238
  • Modification sites at PhosphoSitePlus

Domains & Families for PSMA4 Gene

Gene Families for PSMA4 Gene

Suggested Antigen Peptide Sequences for PSMA4 Gene

Graphical View of Domain Structure for InterPro Entry

P25789

UniProtKB/Swiss-Prot:

PSA4_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA4: view

Function for PSMA4 Gene

Molecular function for PSMA4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
UniProtKB/Swiss-Prot Induction:
Down-regulated by antioxidants BO-653 and probucol.

Enzyme Numbers (IUBMB) for PSMA4 Gene

Gene Ontology (GO) - Molecular Function for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12376572
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMA4: view
genes like me logo Genes that share phenotypes with PSMA4: view

Animal Model Products

miRNA for PSMA4 Gene

miRTarBase miRNAs that target PSMA4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA4 Gene

Localization for PSMA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA4 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMA4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA,IDA 17323924
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA --
genes like me logo Genes that share ontologies with PSMA4: view

Pathways & Interactions for PSMA4 Gene

SuperPathways for PSMA4 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMA4: view

Gene Ontology (GO) - Biological Process for PSMA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMA4: view

No data available for SIGNOR curated interactions for PSMA4 Gene

Drugs & Compounds for PSMA4 Gene

(4) Drugs for PSMA4 Gene - From: DrugBank, PharmGKB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
cotinine Pharma 0
genes like me logo Genes that share compounds with PSMA4: view

Transcripts for PSMA4 Gene

Unigene Clusters for PSMA4 Gene

Proteasome (prosome, macropain) subunit, alpha type, 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7:
SP8: -

Relevant External Links for PSMA4 Gene

GeneLoc Exon Structure for
PSMA4
ECgene alternative splicing isoforms for
PSMA4

Expression for PSMA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSMA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMA4 Gene

This gene is overexpressed in Nasal epithelium (6.3) and Liver, secretome (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMA4 Gene



Protein tissue co-expression partners for PSMA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMA4 Gene:

PSMA4

SOURCE GeneReport for Unigene cluster for PSMA4 Gene:

Hs.251531
genes like me logo Genes that share expression patterns with PSMA4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMA4 Gene

Orthologs for PSMA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMA4 34 35
  • 99.87 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMA4 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA4 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMA4 34 35
  • 95.15 (n)
rat
(Rattus norvegicus)
Mammalia Psma4 34
  • 91.83 (n)
mouse
(Mus musculus)
Mammalia Psma4 34 16 35
  • 91.32 (n)
chicken
(Gallus gallus)
Aves PSMA4 34 35
  • 84.29 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia psma4 34
  • 84.39 (n)
Str.8679 34
zebrafish
(Danio rerio)
Actinopterygii psma4 34 35
  • 76.93 (n)
Dr.10596 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9056 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004960 34
  • 65.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pros29 36 34 35
  • 63.85 (n)
Prosalpha3T 36 35
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea pas-3 34 35
  • 60.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE9 34 35 37
  • 56.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03917g 34
  • 55.32 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR318W 34
  • 53.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PAC1 34
  • 61.58 (n)
soybean
(Glycine max)
eudicotyledons Gma.3753 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8126 34
rice
(Oryza sativa)
Liliopsida Os06g0176000 34
  • 56.97 (n)
corn
(Zea mays)
Liliopsida Zm.6197 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.27 35
  • 75 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC13C5.01c 34
  • 59.46 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05942 34
  • 57.06 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2454 34
Species where no ortholog for PSMA4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSMA4 Gene

ENSEMBL:
Gene Tree for PSMA4 (if available)
TreeFam:
Gene Tree for PSMA4 (if available)

Paralogs for PSMA4 Gene

Pseudogenes.org Pseudogenes for PSMA4 Gene

genes like me logo Genes that share paralogs with PSMA4: view

No data available for Paralogs for PSMA4 Gene

Variants for PSMA4 Gene

Sequence variations from dbSNP and Humsavar for PSMA4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1052035 -- 78,549,011(-) TTCCT(A/G)GTGTG utr-variant-3-prime
rs1052040 -- 78,549,139(-) ATTAA(A/G)ACGTC utr-variant-3-prime
rs1065640 -- 78,548,915(-) TTTTT(C/T)TTTCT reference, missense, utr-variant-3-prime
rs111361189 -- 78,543,769(+) TTGCC(A/G)TATTG intron-variant
rs111362317 -- 78,549,043(+) TGCAG(C/T)GGGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PSMA4 Gene

Variant ID Type Subtype PubMed ID
nsv1038816 CNV gain 25217958
nsv1116464 OTHER inversion 24896259

Variation tolerance for PSMA4 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA4 Gene

Disorders for PSMA4 Gene

Relevant External Links for PSMA4

Genetic Association Database (GAD)
PSMA4
Human Genome Epidemiology (HuGE) Navigator
PSMA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA4

No disorders were found for PSMA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMA4 Gene

Publications for PSMA4 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T. … Ichihara A. (Biochim. Biophys. Acta 1991) 2 3 4 64
  2. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J. … Platt A. (Pharmacogenomics J. 2013) 3 46 64
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  5. Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans. (PMID: 20587604) Hansen H.M. … Wiencke J.K. (Hum. Mol. Genet. 2010) 3 46 64

Products for PSMA4 Gene

Sources for PSMA4 Gene