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PSMA3 Gene

protein-coding   GIFtS: 67
GCID: GC14P058711

Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteasome (Prosome, Macropain) Subunit, Alpha Type, 31 2     EC 3.4.25.13 8
Macropain Subunit C82 3     PSC32
Multicatalytic Endopeptidase Complex Subunit C82 3     Proteasome Subunit Alpha Type-32
Proteasome Component C82 3     Proteasome Subunit C82
HC82 3     PSC83

External Ids:    HGNC: 95321   Entrez Gene: 56842   Ensembl: ENSG000001005677   OMIM: 1768435   UniProtKB: P257883   

Export aliases for PSMA3 gene to outside databases

Previous GC identifers: GC14P056035 GC14P052507 GC14P056701 GC14P057781 GC14P038877


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSMA3 Gene:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The
core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and
2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high
concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential
function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene
encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts
encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for PSMA3 Gene:
PSMA3 (proteasome (prosome, macropain) subunit, alpha type, 3) is a protein-coding gene. GO annotations related to this gene include threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its
degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R)
isoform 2

Gene Wiki entry for PSMA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSMA3 gene promoter:
         NF-AT2   AP-1   ATF-2   NF-AT3   c-Jun   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMA3 promoter sequence
   Search Chromatin IP Primers for PSMA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSMA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q23

PSMA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMA3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P058711:  view genomic region     (about GC identifiers)

Start:
58,711,523 bp from pter      End:
58,738,730 bp from pter
Size:
27,208 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788 (See protein sequence)
Recommended Name: Proteasome subunit alpha type-3  
Size: 255 amino acids; 28433 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome
core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure.
The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven
beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with AURKB.
Interacts with CDKN1A. Interacts with HIV-1 TAT protein. Interacts with hepatitis C virus (HCV) F protein.
Interacts with Epstein-Barr virus EBNA3 proteins. Interacts with MDM2 and RB1. Interacts with the C-terminus of
TBXA2R isoform 2
Secondary accessions: B2RCK6 Q86U83 Q8N1D8 Q9BS70
Alternative splicing: 2 isoforms:  P25788-1   P25788-2   

Explore the universe of human proteins at neXtProt for PSMA3: NX_P25788

Explore proteomics data for PSMA3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys29, Lys57, Lys110, Lys183, Lys230
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PSMA3 (P25788) (see all 6)
     EVAKIIY  EEAEKYAK  KDKAFELE  VHDEVKDK 


    See PSMA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002779.1  NP_687033.1  

    ENSEMBL proteins: 
     ENSP00000216455   ENSP00000451461   ENSP00000452437   ENSP00000390491   ENSP00000452056  
     ENSP00000450573  
    Reactome Protein details: P25788

    PSMA3 Human Recombinant Protein Products:

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    Novus Biologicals PSMA3 Proteins
    Novus Biologicals PSMA3 Lysate
    Sino Biological Recombinant Protein for PSMA3
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PSMA3
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for PSMA3 (8 products) 

     
    antibodies-online peptides for PSMA3

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    antibodies-online kits for PSMA3 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PSM: Proteasome (prosome, macropain) subunits

    3 InterPro protein domains:
     IPR001353 Proteasome_sua/b
     IPR000426 Proteasome_asu_N
     IPR023332 Proteasome_suA-type

    Graphical View of Domain Structure for InterPro Entry P25788

    ProtoNet protein and cluster: P25788

    1 Blocks protein domain: IPB000426 Proteasome subunit

    UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788
    Similarity: Belongs to the peptidase T1A family


    Find genes that share domains with PSMA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSA3_HUMAN, P25788
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its
    degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R)
    isoform 2
    Catalytic activity: Cleavage of peptide bonds with very broad specificity
    Induction: Down-regulated by antioxidants BO-653 and probucol. Up-regulated by bacterial lipopolysaccharides (LPS)
    and TNF

         Genatlas biochemistry entry for PSMA3:
    multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 3,subunit HC8

         Enzyme Number (IUBMB): EC 3.4.25.11 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity ----
    GO:0004298threonine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI11146632
         
    Find genes that share ontologies with PSMA3           About GenesLikeMe


    Phenotypes:
         8 GenomeRNAi human phenotypes for PSMA3:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased cell number, increas 
     Decreased viability of wild-ty  G2 arrest  Increased cell number in G2M,   Low eccentricity cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PSMA3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PSMA3:
    hsa-mir-26a-5p (MIRT050117), hsa-mir-378a-3p (MIRT043928), hsa-mir-106b-5p (MIRT044295), hsa-mir-346 (MIRT042723)

    Block miRNA regulation of human, mouse, rat PSMA3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PSMA3:
    hsa-miR-4282 hsa-miR-3647-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Sino Biological Human cDNA Clone for PSMA3
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSA3_HUMAN, P25788: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005634nucleus TAS16130169
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS16130169
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PSMA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSMA3 About   (see all 28)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D10.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    2Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    3Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with PSMA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSMA3 (see all 17)
        CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms
    GSK3 Signaling

    1 Cell Signaling Technology (CST) Pathway for PSMA3
        Protein Stability

    4 GeneGo (Thomson Reuters) Pathways for PSMA3
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR

    2 BioSystems Pathways for PSMA3
        Proteasome Degradation
    Aurora B signaling


    Selected Reactome Pathways for PSMA3 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    SCF-beta-TrCP mediated degradation of Emi1
    Ubiquitin-dependent degradation of Cyclin D1
    Orc1 removal from chromatin


    1 Kegg Pathway  (Kegg details for PSMA3):
        Proteasome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSMA3
    Interactions:

        GeneGlobe Interaction Network for PSMA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSMA3 (P257881, 2, 3 ENSP000002164554) via UniProtKB, MINT, STRING, and/or I2D (see all 410)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMA7O148181, 2, 3, ENSP000003599104EBI-348380,EBI-603272 MINT-6176676 MINT-51345 MINT-4050722 MINT-51354 MINT-6176052 MINT-51368 MINT-51335 MINT-8267491 MINT-6176080 I2D: score=11 STRING: ENSP00000359910
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62733 MINT-62635 MINT-62809 I2D: score=5 STRING: ENSP00000387477
    ENSG00000206427P486342, 3MINT-62733 MINT-62635 MINT-62809 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62733 MINT-62635 MINT-62809 I2D: score=5 
    ENSG00000226618P486342, 3MINT-62733 MINT-62635 MINT-62809 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    Find genes that share ontologies with PSMA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSMA3 (PSA3)

    2 DrugBank Compounds for PSMA3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE-- --target--10592235
    N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSMA3 gene (2 alternative transcripts): 
    NM_002788.3  NM_152132.2  

    Unigene Cluster for PSMA3:

    Proteasome (prosome, macropain) subunit, alpha type, 3
    Hs.558799  [show with all ESTs]
    Unigene Representative Sequence: BM918616
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216455(uc001xdj.2 uc001xdk.2 uc021rtt.1) ENST00000554812
    ENST00000553665 ENST00000557087 ENST00000555931 ENST00000554456 ENST00000412908
    ENST00000555743 ENST00000557508 ENST00000556321 ENST00000553677 ENST00000554207
    ENST00000557290
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    hsa-miR-4282 hsa-miR-3647-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat PSMA3
      QuantiFast Probe-based Assays in human, mouse, rat PSMA3

    Additional mRNA sequence: 

    AK315158.1 BC005265.1 BC029402.1 BC038990.1 BT006711.1 BT019715.1 CR456933.1 D00762.1 
    NR_038123.1 

    Selected DOTS entries (see all 25):

    DT.418208  DT.100703585  DT.100880879  DT.100044492  DT.100880895  DT.427712  DT.65285051  DT.95191317 
    DT.120766595  DT.120766741  DT.208775  DT.40126212  DT.91690599  DT.92449580  DT.100035486  DT.120766726 
    DT.91823022  DT.95134620  DT.95147801  DT.95147805  DT.208776  DT.418212  DT.95214729  DT.95308198 

    Selected AceView cDNA sequences (see all 494):

    BU934786 BC005265 CF127664 BM764685 CF128376 AA806917 CA431411 AI370773 
    BQ001334 BU661030 BQ772634 AI886197 AJ713863 BM772482 CR607027 AA322615 
    BM840818 CB158780 AV729433 BQ084419 CR626517 BM014726 CR621171 CA943594 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PSMA3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                                                                          -                                             
    SP2:                          -                                               -                                             
    SP3:                          -                                               -                                             
    SP4:                          -                                                                                             
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for PSMA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PSMA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGTTCC
    PSMA3 Expression
    About this image


    PSMA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    PSMA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSMA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558799
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMA3 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psma31 , 5 proteasome (prosome, macropain) subunit, alpha type more1, 5 92.03(n)1
    98.82(a)1
      12 (29.39 cM)5
    191671  NM_011184.41  NP_035314.31 
     709746215 
    chicken
    (Gallus gallus)
    Aves PSMA31 proteasome (prosome, macropain) subunit, alpha type, more 85.1(n)
    96.08(a)
      423542  NM_001006491.1  NP_001006491.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMA36
    proteasome (prosome, macropain) subunit, alpha typ...
    95(a)
    1 ↔ 1
    GL343459.1(302942-322220)
    African clawed frog
    (Xenopus laevis)
    Amphibia psma3-prov2 proteasome (prosome, macropain) subunit, alpha type, more 80.15(n)    BC041518.1 
    zebrafish
    (Danio rerio)
    Actinopterygii psma31 proteasome (prosome, macropain) subunit, alpha type, more 77.65(n)
    88.63(a)
      564370  NM_001030187.1  NP_001025358.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Prosalpha71 , 3 proteasome endopeptidase3
    Proteasome alpha7 subunit1
    57(a)3
    58.57(n)1
    57.77(a)1
      46B73
    360181  NM_165703.31  NP_724834.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pas-71 pas-7 56(n)
    49.2(a)
      174571  NM_063776.3  NP_496177.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRE10(YOR362C)4
    PRE101
    Alpha 7 subunit of the 20S proteasome4
    PRE101
    56.04(n)1
    52.76(a)1
      15(1018746-1017880)4
    8545441, 4  NP_015007.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PAG11 PAG1 60.59(n)
    61.54(a)
      817244  NM_128260.4  NP_180270.1 
    rice
    (Oryza sativa)
    Liliopsida Os.37062 Oryza sativa (japonica cultivar-group) OsPAG1 mRNA more 75.23(n)    AB026562.1 


    ENSEMBL Gene Tree for PSMA3 (if available)
    TreeFam Gene Tree for PSMA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSMA3 gene
    7 SIMAP similar genes for PSMA3 using alignment to 6 protein entries:     PSA3_HUMAN (see all proteins):
    PSMA6    PSMA5    PSMA2    PSMA4    DKFZp686D09174    PSMA8
    PSMA7

    Find genes that share paralogs with PSMA3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PSMA3
    PGOHUM00000248194 PGOHUM00000243965


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSMA3 (see all 402)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384492431,2
    C--58709584(+) CACCTC/GTTAAA 3 -- us2k10--------
    rs2005275191,2
    C--58709697(+) ATATTC/TCNNNN 3 -- us2k10--------
    rs1906737851,2
    --58709849(+) TTTAAA/GTCAAA 3 -- us2k10--------
    rs1830701051,2
    --58709897(+) TCACAA/GTAGAA 3 -- us2k10--------
    rs1170089611,2
    C,F--58710040(+) TGTACA/CTATTC 3 -- us2k11Minor allele frequency- C:0.01NA 120
    rs118497661,2
    C,F,H--58710066(+) acaagA/Gtacta 3 -- us2k17Minor allele frequency- G:0.04NS NA WA 794
    rs791540421,2
    C--58710125(+) TGATC-/AAAAGTT 3 -- us2k10--------
    rs101454191,2
    C,F,H--58710248(+) atcaaA/Gtaaca 3 -- us2k17Minor allele frequency- G:0.10NS NA WA 912
    rs342807461,2
    C--58710451(+) AAAAA-/ATGCAT 3 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1473128041,2
    C--58710602(+) ATGCTA/GATGCC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PSMA3 (58711523 - 58738730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PSMA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901985CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSMA3
    DNA2.0 Custom Variant and Variant Library Synthesis for PSMA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176843    OMIM disorders: --


    Find genes that share disorders with PSMA3           About GenesLikeMe


    Export disorders for PSMA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSMA3 gene, integrated from 10 sources (see all 137):
    (articles sorted by number of sources associating them with PSMA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PubMed id 2025653)1, 2, 3 Tamura T.... Ichihara A. (Biochim. Biophys. Acta 1991)
    2. Ubiquitin-independent degradation of hepatitis C virus F protein. (PubMed id 18971267)1, 2 Yuksek K.... Ou J.-H. (J. Virol. 2009)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. Epstein-Barr virus EBNA3 proteins bind to the C8/alpha7 subunit of the 20S proteasome and are degraded by 20S proteasomes in vitro, but are very stable in latently infected B cells. (PubMed id 15831937)1, 2 Touitou R.... Allday M.J. (J. Gen. Virol. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Human Aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner. (PubMed id 14674694)1, 2 Shu F.... Yu L. (Mol. Cell. Biochem. 2003)
    10. Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PubMed id 14550573)1, 2 Apcher G.S.... Krueger E. (FEBS Lett. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5684 HGNC: 9532 AceView: PSMA3 Ensembl:ENSG00000100567 euGenes: HUgn5684
    ECgene: PSMA3 Kegg: 5684 H-InvDB: PSMA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSMA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSMA3 gene:
    Search GeneIP for patents involving PSMA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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