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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSMA3 Gene

protein-coding   GIFtS: 67
GCID: GC14P058711

Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Proteasome (Prosome, Macropain) Subunit, Alpha Type, 31 2     EC 3.4.25.13 8
Macropain Subunit C82 3     PSC32
Multicatalytic Endopeptidase Complex Subunit C82 3     Proteasome Subunit Alpha Type-32
Proteasome Component C82 3     Proteasome Subunit C82
HC82 3     PSC83

External Ids:    HGNC: 95321   Entrez Gene: 56842   Ensembl: ENSG000001005677   OMIM: 1768435   UniProtKB: P257883   
ORGUL members:         
NONCODE14:n410720      

Export aliases for PSMA3 gene to outside databases

Previous GC identifers: GC14P056035 GC14P052507 GC14P056701 GC14P057781 GC14P038877


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMA3 Gene:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The
core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and
2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high
concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential
function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene
encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts
encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for PSMA3 Gene: 
PSMA3 (proteasome (prosome, macropain) subunit, alpha type, 3) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with PSMA3 include huntington's disease, and retinoblastoma, and among its related super-pathways are Regulation of APC/C activators between G1/S and early anaphase and Mitotic Anaphase. GO annotations related to this gene include protein binding and threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its
degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R)
isoform 2

Gene Wiki entry for PSMA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSMA3 gene promoter:
         NF-AT2   AP-1   ATF-2   NF-AT3   c-Jun   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSMA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSMA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q23

PSMA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMA3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P058711:  view genomic region     (about GC identifiers)

Start:
58,711,523 bp from pter      End:
58,738,730 bp from pter
Size:
27,208 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788 (See protein sequence)
Recommended Name: Proteasome subunit alpha type-3  
Size: 255 amino acids; 28433 Da
Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome
core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure.
The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven
beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with AURKB.
Interacts with CDKN1A. Interacts with HIV-1 TAT protein. Interacts with hepatitis C virus (HCV) F protein.
Interacts with Epstein-Barr virus EBNA3 proteins. Interacts with MDM2 and RB1. Interacts with the C-terminus of
TBXA2R isoform 2
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B2RCK6 Q86U83 Q8N1D8 Q9BS70
Alternative splicing: 2 isoforms:  P25788-1   P25788-2   

Explore the universe of human proteins at neXtProt for PSMA3: NX_P25788

Explore proteomics data for PSMA3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P25788

  • 4/6 DME Specific Peptides for PSMA3 (P25788) (see all 6)
     EVAKIIY  EEAEKYAK  KDKAFELE  VHDEVKDK 

    PSMA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PSMA3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002779.1  NP_687033.1  

    ENSEMBL proteins: 
     ENSP00000216455   ENSP00000451461   ENSP00000452437   ENSP00000390491   ENSP00000452056  
     ENSP00000450573  
    Reactome Protein details: P25788
    Human Recombinant Protein Products for PSMA3: 
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    OriGene Protein Over-expression Lysate for PSMA3
    OriGene MassSpec for PSMA3 
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    Novus Biologicals PSMA3 Proteins
    Novus Biologicals PSMA3 Lysate
    Sino Biological Recombinant Protein for PSMA3
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PSMA3
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex TAS8811196
    GO:0005634nucleus TAS16130169
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS16130169
    GO:0005829cytosol TAS--

    PSMA3 for ontologies           About GeneDecksing



    PSMA3 Antibody Products: 
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    Assay Products for PSMA3: 
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    GenScript Custom Assay Services for PSMA3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PSM: Proteasome (prosome, macropain) subunits

    3 InterPro protein domains:
     IPR001353 Proteasome_sua/b
     IPR000426 Proteasome_asu_N
     IPR023332 Proteasome_suA-type

    Graphical View of Domain Structure for InterPro Entry P25788

    ProtoNet protein and cluster: P25788

    1 Blocks protein domain: IPB000426 Proteasome subunit

    UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788
    Similarity: Belongs to the peptidase T1A family


    PSMA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSA3_HUMAN, P25788
    Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave
    peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The
    proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its
    degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R)
    isoform 2
    Catalytic activity: Cleavage of peptide bonds with very broad specificity
    Induction: Down-regulated by antioxidants BO-653 and probucol. Up-regulated by bacterial lipopolysaccharides (LPS)
    and TNF

         Genatlas biochemistry entry for PSMA3:
    multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 3,subunit HC8

         Enzyme Number (IUBMB): EC 3.4.25.11 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity ----
    GO:0004298threonine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI11146632
         
    PSMA3 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for PSMA3:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased cell number, increas 
     Decreased viability of wild-ty  G2 arrest  Increased cell number in G2M,   Low eccentricity cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PSMA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PSMA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSMA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSMA3 

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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMA3:
    hsa-miR-4282 hsa-miR-3647-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for PSMA3
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PSMA3 About   (see all 31)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Removal of licensing factors from origins0.89
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    Regulation of DNA replication0.89
    CDK-mediated phosphorylation and removal of Cdc60.94
    Cyclin E associated events during G1/S transition 0.89
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Switching of origins to a post-replicative state0.89
    2M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    3Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    SREBP Proteolysis0.43
    G2-M Phase Transition0.59
    DNA Repair Mechanisms0.32
    Estrogen-mediated S-Phase Entry0.55
    4Metabolism of mRNA
    Metabolism of RNA0.92
    Metabolism of mRNA0.92
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PSMA3
        Immune response Antigen presentation by MHC class I
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMA3 (see all 17)
        CDK5 Pathway
    Estrogen-mediated S-Phase Entry
    G2-M Phase Transition
    DNA Repair Mechanisms
    GSK3 Signaling

    1 Cell Signaling Technology (CST) Pathway for PSMA3
        Protein Stability

    4 GeneGo (Thomson Reuters) Pathways for PSMA3
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Antigen presentation by MHC class I
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR

    2 BioSystems Pathways for PSMA3
        Proteasome Degradation
    Aurora B signaling


    5/74        Reactome Pathways for PSMA3 (see all 74)
        Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway
    CDT1 association with the CDC6:ORC:origin complex
    Autodegradation of the E3 ubiquitin ligase COP1


    1         Kegg Pathway  (Kegg details for PSMA3):
        Proteasome


    PSMA3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PSMA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/351 Interacting proteins for PSMA3 (P257881, 2, 3 ENSP000002164554) via UniProtKB, MINT, STRING, and/or I2D (see all 351)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMA7O148181, 2, 3, ENSP000003599104EBI-348380,EBI-603272 MINT-6176676 MINT-51345 MINT-4050722 MINT-51354 MINT-6176052 MINT-51368 MINT-51335 MINT-8267491 MINT-6176080 I2D: score=11 STRING: ENSP00000359910
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62733 MINT-62635 MINT-62809 I2D: score=5 STRING: ENSP00000387477
    ENSG00000206427P486342, 3MINT-62733 MINT-62635 MINT-62809 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62733 MINT-62635 MINT-62809 I2D: score=5 
    ENSG00000226618P486342, 3MINT-62733 MINT-62635 MINT-62809 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000209protein polyubiquitination TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--

    PSMA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PSMA3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

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    2 DrugBank Compounds for PSMA3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE-- --target--10592235
    N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about PSMA3 / PSA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PSMA3 gene (2 alternative transcripts): 
    NM_002788.3  NM_152132.2  

    Unigene Cluster for PSMA3:

    Proteasome (prosome, macropain) subunit, alpha type, 3
    Hs.558799  [show with all ESTs]
    Unigene Representative Sequence: BM918616
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216455(uc001xdj.2 uc001xdk.2 uc021rtt.1) ENST00000554812
    ENST00000553665 ENST00000557087 ENST00000555931 ENST00000554456 ENST00000412908
    ENST00000555743 ENST00000557508 ENST00000556321 ENST00000553677 ENST00000554207
    ENST00000557290
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMA3

    Additional mRNA sequence: 

    AK315158.1 BC005265.1 BC029402.1 BC038990.1 BT006711.1 BT019715.1 CR456933.1 D00762.1 
    NR_038123.1 

    24/25 DOTS entries (see all 25):

    DT.418208  DT.100703585  DT.100880879  DT.100044492  DT.100880895  DT.427712  DT.65285051  DT.95191317 
    DT.120766595  DT.120766741  DT.208775  DT.40126212  DT.91690599  DT.92449580  DT.100035486  DT.120766726 
    DT.91823022  DT.95134620  DT.95147801  DT.95147805  DT.208776  DT.418212  DT.95214729  DT.95308198 

    24/494 AceView cDNA sequences (see all 494):

    AA312072 CA865609 NM_152132 BE791761 BX363762 CF594039 BM763800 AI886197 
    BM764685 CR626135 CB157476 AV658620 BU628307 CA431285 AA322615 CR626517 
    BM772482 AA858014 CA447203 BM999954 BM699263 AI370773 CA774487 CR615289 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PSMA3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                                                                          -                                             
    SP2:                          -                                               -                                             
    SP3:                          -                                               -                                             
    SP4:                          -                                                                                             
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for PSMA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSMA3 expression in normal human tissues (normalized intensities)      PSMA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGTTCC
    PSMA3 Expression
    About this image


    PSMA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Brain (Nervous System)
             Medulla Oblongata

     -- (Gastrointestinal Tract)
             visceral organ/oral region/gland   

    See PSMA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSMA3

    SOURCE GeneReport for Unigene cluster: Hs.558799
        SABiosciences Custom PCR Arrays for PSMA3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSMA3 gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psma31 , 5 proteasome (prosome, macropain) subunit, alpha type more1, 5 92.03(n)1
    98.82(a)1
      12 (29.39 cM)5
    191671  NM_011184.41  NP_035314.31 
     709746215 
    chicken
    (Gallus gallus)
    Aves PSMA31 proteasome (prosome, macropain) subunit, alpha type, more 85.1(n)
    96.08(a)
      423542  NM_001006491.1  NP_001006491.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSMA36
    Proteasome subunit alpha type
    95(a)
    1 ↔ 1
    GL343459.1(302942-322220)
    African clawed frog
    (Xenopus laevis)
    Amphibia psma3-prov2 proteasome (prosome, macropain) subunit, alpha type, more 80.15(n)    BC041518.1 
    zebrafish
    (Danio rerio)
    Actinopterygii psma31 proteasome (prosome, macropain) subunit, alpha type, more 77.65(n)
    88.63(a)
      564370  NM_001030187.1  NP_001025358.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Prosalpha71 , 3 proteasome endopeptidase3
    Proteasome alpha7 subunit1
    57(a)3
    58.57(n)1
    57.77(a)1
      46B73
    360181  NM_165703.21  NP_724834.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pas-71 Protein PAS-7 56(n)
    49.2(a)
      174571  NM_063776.2  NP_496177.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRE10(YOR362C)4
    PRE101
    Alpha 7 subunit of the 20S proteasome4
    Pre10p1
    55.99(n)1
    51.78(a)1
      15(1018746-1017880)4
    8545441, 4  NP_015007.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PAG11 proteasome subunit alpha type-3 60.59(n)
    61.54(a)
      817244  NM_128260.4  NP_180270.1 
    rice
    (Oryza sativa)
    Liliopsida Os.37062 Oryza sativa (japonica cultivar-group) OsPAG1 mRNA more 75.23(n)    AB026562.1 


    ENSEMBL Gene Tree for PSMA3 (if available)
    TreeFam Gene Tree for PSMA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSMA3 gene
    7 SIMAP similar genes for PSMA3 using alignment to 6 protein entries:     PSA3_HUMAN (see all proteins):
    PSMA6    PSMA5    PSMA2    PSMA4    DKFZp686D09174    PSMA8
    PSMA7

    PSMA3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PSMA3
    PGOHUM00000248194 PGOHUM00000243965


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/402 SNPs in PSMA3 are shown (see all 402)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384492431,2
    C--58709584(+) CACCTC/GTTAAA 3 -- us2k10--------
    rs2005275191,2
    C--58709697(+) ATATTC/TCNNNN 3 -- us2k10--------
    rs1906737851,2
    --58709849(+) TTTAAA/GTCAAA 3 -- us2k10--------
    rs1830701051,2
    --58709897(+) TCACAA/GTAGAA 3 -- us2k10--------
    rs1170089611,2
    C,F--58710040(+) TGTACA/CTATTC 3 -- us2k11Minor allele frequency- C:0.01NA 120
    rs118497661,2
    C,F,H--58710066(+) acaagA/Gtacta 3 -- us2k17Minor allele frequency- G:0.04NS NA WA 794
    rs791540421,2
    C--58710125(+) TGATC-/AAAAGTT 3 -- us2k10--------
    rs101454191,2
    C,F,H--58710248(+) atcaaA/Gtaaca 3 -- us2k17Minor allele frequency- G:0.10NS NA WA 912
    rs342807461,2
    C--58710451(+) AAAAA-/ATGCAT 3 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1473128041,2
    C--58710602(+) ATGCTA/GATGCC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PSMA3 (58711523 - 58738730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PSMA3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv901985CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176843    OMIM disorders: --

    10 diseases for PSMA3:    About MalaCards
    huntington's disease    retinoblastoma    hepatitis c    ataxia
    parkinson's disease    hepatitis    endotheliitis    prostate cancer
    breast cancer    prostatitis


    PSMA3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for PSMA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSMA3 gene, integrated from 9 sources (see all 128):
    (articles sorted by number of sources associating them with PSMA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PubMed id 2025653)1, 2, 3 Tamura T.... Ichihara A. (1991)
    2. Ubiquitin-independent degradation of hepatitis C virus F protein. (PubMed id 18971267)1, 2 Yuksek K.... Ou J.-H. (2009)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. Epstein-Barr virus EBNA3 proteins bind to the C8/alpha7 subunit of the 20S proteasome and are degraded by 20S proteasomes in vitro, but are very stable in latently infected B cells. (PubMed id 15831937)1, 2 Touitou R.... Allday M.J. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner. (PubMed id 14674694)1, 2 Shu F....Yu L. (2003)
    10. Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PubMed id 14550573)1, 2 Apcher G.S.... Krueger E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5684 HGNC: 9532 AceView: PSMA3 Ensembl:ENSG00000100567 euGenes: HUgn5684
    ECgene: PSMA3 Kegg: 5684 H-InvDB: PSMA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSMA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PSMA3 gene:
    Search GeneIP for patents involving PSMA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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