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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PSMA3 Gene

protein-coding GIFtS: 66
GCID: GC14P058711

proteasome (prosome, macropain) subunit, alpha type, 3

Explore 9 diseases affiliated with
PSMA3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3¹ ²		EC 3.4.25.1³ ⁸
HC8¹ ² ³		PSC3²
Macropain Subunit C8² ³		Proteasome Subunit Alpha Type-3²
Multicatalytic Endopeptidase Complex Subunit C8² ³		Proteasome Subunit C8²
Proteasome Component C8² ³		PSC8³

External Ids:	HGNC: 9532¹	Entrez Gene: 5684²	Ensembl: ENSG00000100567⁷	OMIM: 176843⁵	UniProtKB: P25788³

ORGUL members:
	NONCODE:n410720

Export aliases for PSMA3 gene to outside databases

Previous GC identifers: GC14P056035 GC14P052507 GC14P056701 GC14P057781 GC14P038877

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSMA3:

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core

structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings

are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and

cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified

proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the

peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have

been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788

Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave

peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The

proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its

degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R)

isoform 2

Gene Wiki entry for PSMA3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PSMA3 gene promoter:
NF-AT2 AP-1 ATF-2 NF-AT3 c-Jun NF-AT1 NF-AT
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSMA3 promoter sequence

Search SABiosciences Chromatin IP Primers for PSMA3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSMA3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23 Ensembl cytogenetic band: 14q23.1 HGNC cytogenetic band: 14q23

PSMA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSMA3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P058711: view genomic region (about GC identifiers)

Start:	58,711,549 bp from pter	End:	58,738,730 bp from pter
Size:	27,182 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788 (See protein sequence)

Recommended Name: Proteasome subunit alpha type-3

Size: 255 amino acids; 28433 Da

Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core

is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two

end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.

The catalytic chamber with the active sites is on the inside of the barrel. Interacts with AURKB. Interacts with

CDKN1A. Interacts with HIV-1 TAT protein. Interacts with hepatitis C virus (HCV) F protein. Interacts with

Epstein-Barr virus EBNA3 proteins. Interacts with MDM2 and RB1. Interacts with the C-terminus of TBXA2R isoform 2

Subcellular location: Cytoplasm. Nucleus

Secondary accessions: B2RCK6 Q86U83 Q8N1D8 Q9BS70

Alternative splicing: 2 isoforms: P25788-1 P25788-2

Explore the universe of human proteins at neXtProt for PSMA3: NX_P25788

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P25788

4/6 DME Specific Peptides for PSMA3 (P25788) (see all 6)

EVAKIIY

EEAEKYAK

KDKAFELE

VHDEVKDK

PSMA3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002779.1 NP_687033.1

ENSEMBL proteins:

ENSP00000216455 ENSP00000451461 ENSP00000452437 ENSP00000390491 ENSP00000452056

ENSP00000450573

Reactome Protein details: P25788
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PSMA3 OriGene Protein Over-expression Lysate (see all 2): PSMA3 OriGene Custom Protein Services for PSMA3
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	Novus Biologicals PSMA3 Proteins Novus Biologicals PSMA3 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PSMA3
	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	TAS	8811196
GO:0005634	nucleus	TAS	16130169
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	TAS	16130169
GO:0005829	cytosol	TAS	--

PSMA3 for ontologies About GeneDecksing

PSMA3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PSMA3
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PSMA3
	OriGene Antibodies (see all 2): PSMA3 OriGene Custom Antibody Services for PSMA3
	GenScript Custom Superior Antibodies Services for PSMA3
	Novus Biologicals PSMA3 Antibodies
	Abcam antibodies for PSMA3
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for PSMA3

Assay Products for PSMA3:

	EMD Millipore Kits and Assays for the Analysis of PSMA3
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PSMA3
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PSMA3 for domains About GeneDecksing

3 InterPro domains/families:

IPR001353 Proteasome_sua/b

IPR000426 Proteasome_asu_N

IPR023332 Proteasome_suA-type

Graphical View of Domain Structure for InterPro Entry P25788

ProtoNet protein and cluster: P25788

1 Blocks protein family: IPB000426 Proteasome subunit

UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788

Similarity: Belongs to the peptidase T1A family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PSA3_HUMAN, P25788

Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave

peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The

proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its

degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R)

isoform 2

Catalytic activity: Cleavage of peptide bonds with very broad specificity

Induction: Down-regulated by antioxidants BO-653 and probucol. Up-regulated by bacterial lipopolysaccharides (LPS) and

TNF

Genatlas biochemistry entry for PSMA3:

multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 3,subunit HC8

Enzyme Number (IUBMB): EC 3.4.25.1¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PSMA3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMA3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMA3:
		hsa-miR-4282 hsa-miR-3647-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSMA3 (see all 4) OriGene shRNA RFP: PSMA3 OriGene siRNA: PSMA3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMA3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PSMA3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMA3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMA3 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PSMA3 (NM_002788)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSMA3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMA3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PSMA3
		Search LifeMap BioReagents cell lines for PSMA3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMA3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004175	endopeptidase activity	--	--
GO:0004298	threonine-type endopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	19208651

PSMA3 for ontologies About GeneDecksing

8 GenomeRNAi human phenotypes for PSMA3:

Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased cell number, increas
Decreased viability of wild-ty	G2 arrest	Increased cell number in G2M,	Low eccentricity cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/78 pathways (see all 78)
Ubiquitinated Orc1 is degraded by the proteasome	1.00	Degradation of ubiquitinated p27/p21 by the 26S proteasome	0.75
Proteasomal cleavage of substrate	0.98	SCF(Skp2)-mediated degradation of p27/p21	0.75
Proteasome mediated degradation of PAK-2p34	0.98	APC/C:Cdh1-mediated degradation of Skp2	0.74
Proteasomal cleavage of substrate	0.98	APC/C:Cdc20 mediated degradation of Securin	0.74

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Chks in Checkpoint Regulation

Chks in Checkpoint Regulation	1.00	p53 Signaling	0.32
G2-M Phase Transition	0.59	DNA Repair Mechanisms	0.32
Estrogen-mediated S-Phase Entry	0.55

HIV Infection

	HIV Infection	1.00			Transcription_Ligand-Dependent Transcription of Retinoid-Target genes	0.28
	Host Interactions of HIV factors	0.64			Transcription Ligand-Dependent Transcription of Retinoid-Target genes	0.28

Regulation of degradation of wt-CFTR

Regulation of degradation of wt-CFTR

1.00

Regulation of degradation of deltaF508 CFTR in CF

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for PSMA3

	Immune response Antigen presentation by MHC class I
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSMA3 (see all 17)

	CDK5 Pathway
	Estrogen-mediated S-Phase Entry
	G2-M Phase Transition
	DNA Repair Mechanisms
	GSK3 Signaling

1 Cell Signaling Technology (CST) Pathway for PSMA3

Protein Stability

4 GeneGo (Thomson Reuters) Pathways for PSMA3

	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Immune response Antigen presentation by MHC class I
	Regulation of degradation of deltaF508 CFTR in CF
	Regulation of degradation of wt-CFTR

2 BioSystems Pathways for PSMA3

	Proteasome Degradation
	Aurora B signaling

5/98 Reactome Pathways for PSMA3 (see all 98)

	Ubiquitinated geminin is degraded by the proteasome
	Proteolytic degradation of ubiquitinated-Cdc25A
	Orc1 removal from chromatin
	CDK-mediated phosphorylation and removal of Cdc6
	ER-Phagosome pathway

1 Kegg Pathway (Kegg details for PSMA3):

Proteasome

PSMA3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PSMA3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/335 Interacting proteins for PSMA3 (P25788^{1, 2, 3} ENSP00000216455⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 335)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMA7	O14818¹^,²^,³, ENSP00000359910⁴	EBI-348380,EBI-603272 MINT-6176676 MINT-51345 MINT-4050722 MINT-51354 MINT-6176052 MINT-51368 MINT-51335 MINT-8267491 MINT-6176080 I2D: score=11 STRING: ENSP00000359910
PSMA4	P25789¹^,²^,³, ENSP00000044462⁴	EBI-348380,EBI-359310 MINT-4050722 MINT-51344 MINT-51348 MINT-51361 MINT-6176676 MINT-6176052 MINT-6176080 I2D: score=11 STRING: ENSP00000044462
PSMA1	P25786¹^,²^,³	EBI-348380,EBI-359352 MINT-4050722 MINT-6176676 MINT-6176052 MINT-6176080 I2D: score=20
PSMA2	P25787²^,³, ENSP00000223321⁴	MINT-4050722 MINT-6176676 MINT-6176052 MINT-6176080 I2D: score=11 STRING: ENSP00000223321
PSMB2	P49721²^,³, ENSP00000362334⁴	MINT-4050722 MINT-6176676 MINT-6176080 I2D: score=7 STRING: ENSP00000362334

About this table

Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000209	protein polyubiquitination	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--

PSMA3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for PSMA3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PSMA3

2 DrugBank Compounds for PSMA3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE	--	--	target	--	10592235
N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about PSMA3 / PSA3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PSMA3 gene (2 alternative transcripts):

NM_002788.3 NM_152132.2

Unigene Cluster for PSMA3:

Proteasome (prosome, macropain) subunit, alpha type, 3

Hs.558799 [show with all ESTs]

Unigene Representative Sequence: BM918616

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216455(uc001xdj.2 uc001xdk.2 uc021rtt.1) ENST00000554812

ENST00000553665 ENST00000557087 ENST00000555931 ENST00000554456 ENST00000412908

ENST00000555743 ENST00000557508 ENST00000556321 ENST00000553677 ENST00000554207

ENST00000557290

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSMA3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate PSMA3:
		hsa-miR-4282 hsa-miR-3647-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSMA3 (see all 4) OriGene shRNA RFP: PSMA3 OriGene siRNA: PSMA3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSMA3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSMA3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSMA3 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PSMA3 (NM_002788)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSMA3

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PSMA3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMA3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMA3

Additional cDNA sequence:

AK315158.1 BC005265.1 BC029402.1 BC038990.1 BT006711.1 BT019715.1 CR456933.1 D00762.1

NR_038123.1

24/25 DOTS entries (see all 25):

DT.418208 DT.100703585 DT.100880879 DT.100044492 DT.100880895 DT.427712 DT.65285051 DT.95191317

DT.120766595 DT.120766741 DT.208775 DT.40126212 DT.91690599 DT.92449580 DT.100035486 DT.120766726

DT.91823022 DT.95134620 DT.95147801 DT.95147805 DT.208776 DT.418212 DT.95214729 DT.95308198

24/494 AceView cDNA sequences (see all 494):

BQ045387 BM830979 BM769235 BG028576 AW467587 BM509763 BM831095 AI086064

BC005265 AI202123 BQ001334 BF222549 AA806917 BQ955290 BM689530 BM764685

BU682999 AL705507 BQ230518 AI554667 BQ084419 CB157476 CR607027 AI288939

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PSMA3 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12
SP1:																									-
SP2:									-																-
SP3:									-																-
SP4:									-
SP5:

ECgene alternative splicing isoforms for PSMA3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PSMA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTGTTCC

About this image

PSMA3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Medulla Oblongata

Brain

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PSMA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSMA3

SOURCE GeneReport for Unigene cluster: Hs.558799

SABiosciences Custom PCR Arrays for PSMA3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSMA3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSMA3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSMA3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSMA3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA3 gene from 9/42 species (see all 42) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PSMA3¹	proteasome (prosome, macropain) subunit, alpha type, more	85.1(n) 96.08(a)		423542 NM_001006491.1 NP_001006491.1
lizard (Anolis carolinensis)	Reptilia	PSMA3⁶	--	95(a)	1 ↔ 1	GL343459.1(303527-320087)
African clawed frog (Xenopus laevis)	Amphibia	psma3-prov²	proteasome (prosome, macropain) subunit, alpha type, more	80.15(n)		BC041518.1
zebrafish (Danio rerio)	Actinopterygii	psma3¹	proteasome (prosome, macropain) subunit, alpha type, more	77.65(n) 88.63(a)		564370 NM_001030187.1 NP_001025358.1
fruit fly (Drosophila melanogaster)	Insecta	Prosalpha7^{1 , 3}	proteasome endopeptidase³ Proteasome alpha7 subunit¹	57(a)³ 58.57(n)¹ 57.77(a)¹		46B7³ 36018¹ NM_165703.2¹ NP_724834.1¹
worm (Caenorhabditis elegans)	Secernentea	pas-7¹	Protein PAS-7	56(n) 49.2(a)		174571 NM_063776.2 NP_496177.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	PRE10(YOR362C)⁴ PRE10¹	Alpha 7 subunit of the 20S proteasome⁴ Pre10p¹	55.99(n)¹ 51.78(a)¹		15(1018746-1017880)⁴ 854544^{1, 4} NP_015007.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	PAG1¹	proteasome subunit alpha type-3	60.59(n) 61.54(a)		817244 NM_128260.4 NP_180270.1
rice (Oryza sativa)	Liliopsida	Os.3706²	Oryza sativa (japonica cultivar-group) OsPAG1 mRNA more	75.23(n)		AB026562.1

ENSEMBL Gene Tree for PSMA3 (if available)
TreeFam Gene Tree for PSMA3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PSMA3 gene

7 SIMAP similar genes for PSMA3 using alignment to 6 protein entries: PSA3_HUMAN (see all proteins):

PSMA6 PSMA5 PSMA2 PSMA4 DKFZp686D09174 PSMA8

PSMA7

PSMA3 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for PSMA3
PGOHUM00000248194 PGOHUM00000243965

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138449243^1,2		--	58709584(+)	`CACCTC/GTTAAA`	3	--	us2k¹		0	--	--	--	--
rs200527519^1,2	C	--	58709697(+)	`ATATTC/TCNNNN`	3	--	us2k¹		0	--	--	--	--
rs190673785^1,2		--	58709849(+)	`TTTAAA/GTCAAA`	3	--	us2k¹		0	--	--	--	--
rs183070105^1,2		--	58709897(+)	`TCACAA/GTAGAA`	3	--	us2k¹		0	--	--	--	--
rs117008961^1,2		--	58710040(+)	`TGTACA/CTATTC`	3	--	us2k¹		1		NA	120
rs11849766^1,2	C,F,H,	--	58710066(+)	`ACAAGA/GTACTA`	3	--	us2k¹		7		NS NA WA	794
rs79154042^1,2	C,	--	58710125(+)	`TGATC-/AAAAGTT`	3	--	us2k¹		0	--	--	--	--
rs10145419^1,2	C,F,H,	--	58710248(+)	`ATCAAA/GTAACA`	3	--	us2k¹		7		NS NA WA	912
rs34280746^1,2	C	--	58710451(+)	`AAAAA-/ATGCAT`	3	--	us2k¹		1		NA	2
rs147312804^1,2		--	58710602(+)	`ATGCTA/GATGCC`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PSMA3 (58711549 - 58738730 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PSMA3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSMA3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PSMA3 for disorders           About GeneDecksing

OMIM gene information: 176843    OMIM disorders: --

9 diseases for PSMA3:    About MalaCards

hepatitis c retinoblastoma ataxia hepatitis

immunodeficiency malaria huntington's disease parkinson's disease

breast cancer

Export disorders for PSMA3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PSMA3 gene, integrated from 9 sources (see all 117):
(articles sorted by number of sources associating them with PSMA3)

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world of online information

Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PubMed id 2025653)^{1, 2, 3} Tamura T.... Ichihara A. (1991)
Ubiquitin-independent degradation of hepatitis C virus F protein. (PubMed id 18971267)^{1, 2} Yuksek K.... Ou J.-H. (2009)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
Epstein-Barr virus EBNA3 proteins bind to the C8/alpha7 subunit of the 20S proteasome and are degraded by 20S proteasomes in vitro, but are very stable in latently infected B cells. (PubMed id 15831937)^{1, 2} Touitou R.... Allday M.J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner. (PubMed id 14674694)^{1, 2} Shu F....Yu L. (2003)
Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. (PubMed id 14550573)^{1, 2} Apcher G.S.... Krueger E. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5684	HGNC: 9532	AceView: PSMA3	Ensembl:ENSG00000100567	euGenes: HUgn5684
ECgene: PSMA3	Kegg: 5684	H-InvDB: PSMA3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PSMA3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PSMA3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PSMA3 gene:
Search GeneIP for patents involving PSMA3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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PSMA3 Gene

proteasome (prosome, macropain) subunit, alpha type, 3

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