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Aliases for PSMA3 Gene

Aliases for PSMA3 Gene

  • Proteasome Subunit Alpha 3 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3 2 3
  • Multicatalytic Endopeptidase Complex Subunit C8 3 4
  • Proteasome Component C8 3 4
  • Macropain Subunit C8 3 4
  • EC 3.4.25.1 4 58
  • HC8 3 4
  • Testicular Secretory Protein Li 43 3
  • Proteasome Subunit Alpha Type-3 3
  • Proteasome Subunit C8 3
  • PSC3 3
  • PSC8 4

External Ids for PSMA3 Gene

Previous GeneCards Identifiers for PSMA3 Gene

  • GC14P056035
  • GC14P052507
  • GC14P056701
  • GC14P057781
  • GC14P058711
  • GC14P038877

Summaries for PSMA3 Gene

Entrez Gene Summary for PSMA3 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMA3 Gene

PSMA3 (Proteasome Subunit Alpha 3) is a Protein Coding gene. Diseases associated with PSMA3 include Hiv-1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and RET signaling. GO annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMA3 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.

Gene Wiki entry for PSMA3 Gene

Additional gene information for PSMA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA3 Gene

Genomics for PSMA3 Gene

Regulatory Elements for PSMA3 Gene

Enhancers for PSMA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H058242 1.3 ENCODE dbSUPER 0.7 -0.2 -207 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 RNU6-341P ARID4A C14orf37 PSMA3-AS1 ENSG00000258682 PSMA3 TRK-CTT1-1
GH14H058260 0.3 FANTOM5 0.4 +15.6 15616 0 RNU6-341P TOMM20L ENSG00000258682 PSMA3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMA3 on UCSC Golden Path with GeneCards custom track

Promoters for PSMA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069037 295 2601 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207

Genomic Location for PSMA3 Gene

Chromosome:
14
Start:
58,244,805 bp from pter
End:
58,272,012 bp from pter
Size:
27,208 bases
Orientation:
Plus strand

Genomic View for PSMA3 Gene

Genes around PSMA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA3 Gene

Proteins for PSMA3 Gene

  • Protein details for PSMA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25788-PSA3_HUMAN
    Recommended name:
    Proteasome subunit alpha type-3
    Protein Accession:
    P25788
    Secondary Accessions:
    • B2RCK6
    • Q86U83
    • Q8N1D8
    • Q9BS70

    Protein attributes for PSMA3 Gene

    Size:
    255 amino acids
    Molecular mass:
    28433 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with AURKB. Interacts with CDKN1A (PubMed:11350925). Interacts with HIV-1 TAT protein (PubMed:14550573). Interacts with hepatitis C virus (HCV) F protein (PubMed:18971267). Interacts with Epstein-Barr virus EBNA3 proteins (PubMed:15831937). Interacts with MDM2 and RB1 (PubMed:16337594). Interacts with the C-terminus of TBXA2R isoform 2 (PubMed:17499743). Interacts with DNAJB2 (PubMed:15936278).

    Three dimensional structures from OCA and Proteopedia for PSMA3 Gene

    Alternative splice isoforms for PSMA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA3 Gene

Selected DME Specific Peptides for PSMA3 Gene

P25788:
  • EVAKIIY
  • VHDEVKDK
  • EEAEKYAK
  • KDKAFELE
  • AAKTEIEKL
  • YVHAYTLYSAVRPFG

Post-translational modifications for PSMA3 Gene

  • Ubiquitination at isoforms=229, Lys57, Lys110, Lys183, and Lys230
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PSMA3 (PSMA3)

Domains & Families for PSMA3 Gene

Gene Families for PSMA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PSMA3 Gene

Graphical View of Domain Structure for InterPro Entry

P25788

UniProtKB/Swiss-Prot:

PSA3_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA3: view

Function for PSMA3 Gene

Molecular function for PSMA3 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 3,subunit HC8
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
UniProtKB/Swiss-Prot Induction:
Down-regulated by antioxidants BO-653 and probucol. Up-regulated by bacterial lipopolysaccharides (LPS) and TNF.

Enzyme Numbers (IUBMB) for PSMA3 Gene

Phenotypes From GWAS Catalog for PSMA3 Gene

Gene Ontology (GO) - Molecular Function for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 11146632
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMA3: view
genes like me logo Genes that share phenotypes with PSMA3: view

Animal Model Products

CRISPR Products

miRNA for PSMA3 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMA3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA3 Gene

Localization for PSMA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMA3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,IEA 17323924
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,TAS 16130169
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMA3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSMA3 Gene

Pathways & Interactions for PSMA3 Gene

SuperPathways for PSMA3 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMA3: view

Gene Ontology (GO) - Biological Process for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMA3: view

No data available for SIGNOR curated interactions for PSMA3 Gene

Drugs & Compounds for PSMA3 Gene

(4) Drugs for PSMA3 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 814
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
Phenethyl isothiocyanate Investigational Pharma Target 12
genes like me logo Genes that share compounds with PSMA3: view

Transcripts for PSMA3 Gene

Unigene Clusters for PSMA3 Gene

Proteasome (prosome, macropain) subunit, alpha type, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PSMA3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for PSMA3 Gene

GeneLoc Exon Structure for
PSMA3
ECgene alternative splicing isoforms for
PSMA3

Expression for PSMA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMA3 Gene

This gene is overexpressed in Liver, secretome (8.6) and Nasal epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMA3 Gene



Protein tissue co-expression partners for PSMA3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSMA3 Gene:

PSMA3

SOURCE GeneReport for Unigene cluster for PSMA3 Gene:

Hs.558799

Evidence on tissue expression from TISSUES for PSMA3 Gene

  • Pancreas(4.5)
  • Liver(4.4)
  • Bone marrow(4.3)
  • Blood(4.2)
  • Nervous system(3.4)
  • Lung(2.8)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with PSMA3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA3 Gene

Orthologs for PSMA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMA3 33 34
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia PSMA3 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMA3 33 34
  • 94.64 (n)
cow
(Bos Taurus)
Mammalia PSMA3 33 34
  • 93.86 (n)
rat
(Rattus norvegicus)
Mammalia Psma3 33
  • 93.2 (n)
mouse
(Mus musculus)
Mammalia Psma3 33 16 34
  • 92.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA3 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMA3 33 34
  • 85.1 (n)
lizard
(Anolis carolinensis)
Reptilia PSMA3 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia psma3 33
  • 78.95 (n)
Str.10919 33
African clawed frog
(Xenopus laevis)
Amphibia psma3-prov 33
zebrafish
(Danio rerio)
Actinopterygii psma3 33 34
  • 77.65 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6363 33
fruit fly
(Drosophila melanogaster)
Insecta Prosalpha7 35 33 34
  • 58.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001973 33
  • 57.64 (n)
worm
(Caenorhabditis elegans)
Secernentea pas-7 33 34
  • 56 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A03487g 33
  • 57.84 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR401C 33
  • 56.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE10 33 34 36
  • 56.04 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PAG1 33
  • 60.59 (n)
soybean
(Glycine max)
eudicotyledons Gma.11323 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1689 33
rice
(Oryza sativa)
Liliopsida Os01g0811100 33
  • 62.08 (n)
Os.3706 33
barley
(Hordeum vulgare)
Liliopsida Hv.2915 33
wheat
(Triticum aestivum)
Liliopsida Ta.14393 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4861 34
  • 66 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU02493 33
  • 56.8 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pre10 33
  • 54.79 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14529 33
Species where no ortholog for PSMA3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA3 Gene

ENSEMBL:
Gene Tree for PSMA3 (if available)
TreeFam:
Gene Tree for PSMA3 (if available)

Paralogs for PSMA3 Gene

(7) SIMAP similar genes for PSMA3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PSMA3 Gene

genes like me logo Genes that share paralogs with PSMA3: view

No data available for Paralogs for PSMA3 Gene

Variants for PSMA3 Gene

Sequence variations from dbSNP and Humsavar for PSMA3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000181071 -- 58,246,978(+) CTACC(C/T)CACTA intron-variant
rs1000215738 -- 58,247,312(+) TAATG(A/T)ATGAG intron-variant
rs1000286395 -- 58,264,051(+) AGCTG(A/C)TAAGT intron-variant
rs1000401813 -- 58,270,327(+) ATGGA(C/T)GGACA intron-variant
rs1000610452 -- 58,259,100(+) TTAAC(-/AA)AATTT intron-variant

Variation tolerance for PSMA3 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA3 Gene

Human Gene Mutation Database (HGMD)
PSMA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PSMA3 Gene

Disorders for PSMA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMA3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search PSMA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA3
genes like me logo Genes that share disorders with PSMA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA3 Gene

Publications for PSMA3 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T … Ichihara A (Biochimica et biophysica acta 1991) 2 3 4 60
  2. Crystal structure of the human 20S proteasome in complex with carfilzomib. (PMID: 25599644) Harshbarger W … Sacchettini J (Structure (London, England : 1993) 2015) 3 4 60
  3. Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production. (PMID: 26524591) Brehm A … Goldbach-Mansky R (The Journal of clinical investigation 2015) 3 4 60
  4. Ubiquitin-independent degradation of hepatitis C virus F protein. (PMID: 18971267) Yuksek K … Ou JH (Journal of virology 2009) 3 4 60
  5. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X … Huang L (Biochemistry 2007) 3 4 60

Products for PSMA3 Gene

Sources for PSMA3 Gene

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