Aliases for PSMA3 Gene
External Ids for PSMA3 Gene
Previous GeneCards Identifiers for PSMA3 Gene
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for PSMA3 Gene
PSMA3 (Proteasome Subunit Alpha 3) is a Protein Coding gene. Diseases associated with PSMA3 include Hiv-1. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity.
UniProtKB/Swiss-Prot for PSMA3 Gene
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.