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Aliases for PSMA3 Gene

Aliases for PSMA3 Gene

  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3 2 3
  • Multicatalytic Endopeptidase Complex Subunit C8 3 4
  • Proteasome Component C8 3 4
  • Macropain Subunit C8 3 4
  • EC 3.4.25.1 4 64
  • HC8 3 4
  • Proteasome Subunit Alpha Type-3 3
  • Proteasome Subunit C8 3
  • PSC3 3
  • PSC8 4

External Ids for PSMA3 Gene

Summaries for PSMA3 Gene

Entrez Gene Summary for PSMA3 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMA3 Gene

PSMA3 (Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include threonine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PSMA3 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.

Gene Wiki entry for PSMA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA3 Gene

Genomics for PSMA3 Gene

Genomic Location for PSMA3 Gene

Start:
58,244,805 bp from pter
End:
58,272,012 bp from pter
Size:
27,208 bases
Orientation:
Plus strand

Genomic View for PSMA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA3 Gene

Regulatory Elements for PSMA3 Gene

Proteins for PSMA3 Gene

  • Protein details for PSMA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25788-PSA3_HUMAN
    Recommended name:
    Proteasome subunit alpha type-3
    Protein Accession:
    P25788
    Secondary Accessions:
    • B2RCK6
    • Q86U83
    • Q8N1D8
    • Q9BS70

    Protein attributes for PSMA3 Gene

    Size:
    255 amino acids
    Molecular mass:
    28433 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with AURKB. Interacts with CDKN1A. Interacts with HIV-1 TAT protein. Interacts with hepatitis C virus (HCV) F protein. Interacts with Epstein-Barr virus EBNA3 proteins. Interacts with MDM2 and RB1. Interacts with the C-terminus of TBXA2R isoform 2.

    Three dimensional structures from OCA and Proteopedia for PSMA3 Gene

    Alternative splice isoforms for PSMA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA3 Gene

Proteomics data for PSMA3 Gene at MOPED

Selected DME Specific Peptides for PSMA3 Gene

Post-translational modifications for PSMA3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys29, Lys57, Lys110, Lys183, and Lys230

Other Protein References for PSMA3 Gene

Domains for PSMA3 Gene

Gene Families for PSMA3 Gene

HGNC:
  • PSM :Proteasome (prosome, macropain) subunits

Protein Domains for PSMA3 Gene

UniProtKB/Swiss-Prot:

PSA3_HUMAN
Family:
  • Belongs to the peptidase T1A family.:
    • P25788
genes like me logo Genes that share domains with PSMA3: view

Function for PSMA3 Gene

Molecular function for PSMA3 Gene

GENATLAS Biochemistry: multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 3,subunit HC8
UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
UniProtKB/Swiss-Prot Induction: Down-regulated by antioxidants BO-653 and probucol. Up-regulated by bacterial lipopolysaccharides (LPS) and TNF.

Enzyme Numbers (IUBMB) for PSMA3 Gene

Gene Ontology (GO) - Molecular Function for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 11146632
genes like me logo Genes that share ontologies with PSMA3: view
genes like me logo Genes that share phenotypes with PSMA3: view

miRNA for PSMA3 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PSMA3 Gene

Localization for PSMA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA3 Gene COMPARTMENTS Subcellular localization image for PSMA3 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMA3: view

Pathways for PSMA3 Gene

SuperPathways for PSMA3 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Chks in Checkpoint Regulation
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.62
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with PSMA3: view

Gene Ontology (GO) - Biological Process for PSMA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMA3: view

Transcripts for PSMA3 Gene

Unigene Clusters for PSMA3 Gene

Proteasome (prosome, macropain) subunit, alpha type, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for PSMA3 Gene

GeneLoc Exon Structure for
PSMA3
ECgene alternative splicing isoforms for
PSMA3

Expression for PSMA3 Gene

mRNA expression in normal human tissues for PSMA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMA3 Gene

SOURCE GeneReport for Unigene cluster for PSMA3 Gene Hs.558799

genes like me logo Genes that share expressions with PSMA3: view

Orthologs for PSMA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMA3 36
  • 99.74 (n)
  • 100 (a)
PSMA3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSMA3 36
  • 93.86 (n)
  • 98.82 (a)
PSMA3 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMA3 36
  • 94.64 (n)
  • 99.22 (a)
PSMA3 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psma3 36
  • 92.03 (n)
  • 98.82 (a)
Psma3 16
Psma3 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSMA3 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA3 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psma3 36
  • 93.2 (n)
  • 98.82 (a)
chicken
(Gallus gallus)
Aves PSMA3 36
  • 85.1 (n)
  • 96.08 (a)
PSMA3 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMA3 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia psma3-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia psma3 36
  • 78.95 (n)
  • 92.16 (a)
Str.10919 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6363 36
zebrafish
(Danio rerio)
Actinopterygii psma3 36
  • 77.65 (n)
  • 88.63 (a)
psma3 37
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001973 36
  • 57.64 (n)
  • 59.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Prosalpha7 36
  • 58.57 (n)
  • 57.77 (a)
Prosalpha7 37
  • 57 (a)
OneToOne
Prosalpha7 38
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea pas-7 36
  • 56 (n)
  • 49.2 (a)
pas-7 37
  • 49 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR401C 36
  • 56.13 (n)
  • 54.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE10 36
  • 56.04 (n)
  • 52.76 (a)
PRE10 37
  • 45 (a)
OneToOne
PRE10 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A03487g 36
  • 57.84 (n)
  • 54.94 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1689 36
soybean
(Glycine max)
eudicotyledons Gma.11323 36
thale cress
(Arabidopsis thaliana)
eudicotyledons PAG1 36
  • 60.59 (n)
  • 61.54 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2915 36
rice
(Oryza sativa)
Liliopsida Os.3706 36
Os01g0811100 36
  • 62.08 (n)
  • 62.35 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14393 36
bread mold
(Neurospora crassa)
Ascomycetes NCU02493 36
  • 56.8 (n)
  • 55.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pre10 36
  • 54.79 (n)
  • 49.8 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14529 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4861 37
  • 66 (a)
OneToOne
Species with no ortholog for PSMA3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA3 Gene

ENSEMBL:
Gene Tree for PSMA3 (if available)
TreeFam:
Gene Tree for PSMA3 (if available)

Paralogs for PSMA3 Gene

Selected SIMAP similar genes for PSMA3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PSMA3 Gene

genes like me logo Genes that share paralogs with PSMA3: view

No data available for Paralogs for PSMA3 Gene

Variants for PSMA3 Gene

Sequence variations from dbSNP and Humsavar for PSMA3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1137226 -- 58,258,333(+) tactt(A/G)ggagc intron-variant
rs2004312 -- 58,263,044(-) gaccg(C/T)gccac intron-variant
rs2145599 -- 58,262,598(+) tgctc(A/T)gttgc intron-variant
rs2348071 -- 58,263,908(+) ACACT(A/G)ATGAT intron-variant
rs3834523 -- 58,244,049(+) CCACT(-/GT)CTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PSMA3 Gene

Variant ID Type Subtype PubMed ID
nsv901985 CNV Loss 21882294

Relevant External Links for PSMA3 Gene

HapMap Linkage Disequilibrium report
PSMA3

Disorders for PSMA3 Gene

No disorders were found for PSMA3 Gene.

No data available for UniProtKB/Swiss-Prot for PSMA3 Gene

Publications for PSMA3 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T. … Ichihara A. (Biochim. Biophys. Acta 1991) 2 3 4
  2. Human proteasome subunits from 2-dimensional gels identified by partial sequencing. (PMID: 7811265) Kristensen P. … Hendil K.B. (Biochem. Biophys. Res. Commun. 1994) 3 4
  3. A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. (PMID: 11350925) Touitou R. … Allday M.J. (EMBO J. 2001) 3 4
  4. Structure and functions of the 20S and 26S proteasomes. (PMID: 8811196) Coux O. … Goldberg A.L. (Annu. Rev. Biochem. 1996) 2 3
  5. Mapping and structural dissection of human 20 s proteasome using proteomic approaches. (PMID: 12376572) Claverol S. … Monsarrat B. (Mol. Cell. Proteomics 2002) 3 4

Products for PSMA3 Gene

Sources for PSMA3 Gene

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