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Aliases for PSMA2 Gene

Aliases for PSMA2 Gene

  • Proteasome Subunit Alpha 2 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 2 2 3
  • Multicatalytic Endopeptidase Complex Subunit C3 3 4
  • Proteasome Component C3 3 4
  • Macropain Subunit C3 3 4
  • EC 3.4.25.1 4 61
  • HC3 3 4
  • Proteasome Subunit Alpha Type-2 3
  • Proteasome Subunit HC3 3
  • PMSA2 3
  • PSC2 3
  • PSC3 4
  • MU 3

External Ids for PSMA2 Gene

Previous GeneCards Identifiers for PSMA2 Gene

  • GC07M042603
  • GC07M042663
  • GC07M042697
  • GC07M042729
  • GC07M042922
  • GC07M042841
  • GC07M042956

Summaries for PSMA2 Gene

Entrez Gene Summary for PSMA2 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMA2 Gene

PSMA2 (Proteasome Subunit Alpha 2) is a Protein Coding gene. Diseases associated with PSMA2 include Parkinson Disease 15, Autosomal Recessive. Among its related pathways are RET signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is ENSG00000256646.

UniProtKB/Swiss-Prot for PSMA2 Gene

  • Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Gene Wiki entry for PSMA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA2 Gene

Genomics for PSMA2 Gene

Regulatory Elements for PSMA2 Gene

Enhancers for PSMA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G042945 1.1 Ensembl ENCODE 0.4 -13.9 -13884 1.1 HDAC1 HDGF PKNOX1 ATF1 NFRKB CHAMP1 TCF12 EGR1 RELB IKZF2 C7orf25 HECW1 ENSG00000228680 PSMA2 LOC105375253
GH07G042940 1 Ensembl ENCODE 0.4 -9.2 -9160 0.9 CTCF MXI1 CBX3 WRNIP1 MAX ZNF2 RAD21 SCRT2 ZNF143 SMC3 C7orf25 MRPL32 PSMA2 LOC105375253
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSMA2 on UCSC Golden Path with GeneCards custom track

Promoters for PSMA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000211624 -94 3001 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207

Genomic Location for PSMA2 Gene

Chromosome:
7
Start:
42,916,857 bp from pter
End:
42,932,223 bp from pter
Size:
15,367 bases
Orientation:
Minus strand

Genomic View for PSMA2 Gene

Genes around PSMA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA2 Gene

Proteins for PSMA2 Gene

  • Protein details for PSMA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25787-PSA2_HUMAN
    Recommended name:
    Proteasome subunit alpha type-2
    Protein Accession:
    P25787
    Secondary Accessions:
    • Q6ICS6
    • Q9BU45

    Protein attributes for PSMA2 Gene

    Size:
    234 amino acids
    Molecular mass:
    25899 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

    Three dimensional structures from OCA and Proteopedia for PSMA2 Gene

neXtProt entry for PSMA2 Gene

Selected DME Specific Peptides for PSMA2 Gene

P25787:
  • GGVRPFG
  • TTFSPSG
  • DPSGAYF
  • RPFGVSLL
  • NGVVLATEKKQKSILYDE
  • LELEDAIH
  • HTAILTLKE
  • VYSGMGPD
  • RARKLAQQY
  • EPITKHIG
  • GKLVQIE
  • TQSGGVRP
  • LVYQEPIPT
  • TFLEKRY
  • FSLTTFSP

Post-translational modifications for PSMA2 Gene

  • Phosphorylated on tyrosine residues; which may be important for nuclear import.
  • Ubiquitination at isoforms=39, isoforms=53, Lys70, isoforms=92, Lys165, and isoforms=171
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA2 Gene

Domains & Families for PSMA2 Gene

Gene Families for PSMA2 Gene

Suggested Antigen Peptide Sequences for PSMA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25787

UniProtKB/Swiss-Prot:

PSA2_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA2: view

Function for PSMA2 Gene

Molecular function for PSMA2 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 2,subunit HC3,25.9 kDa,would be localized in 7p13-p12 (Trachtulec)
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
UniProtKB/Swiss-Prot Induction:
Down-regulated by antioxidants BO-653 and probucol. Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Enzyme Numbers (IUBMB) for PSMA2 Gene

Gene Ontology (GO) - Molecular Function for PSMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12376572
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PSMA2: view
genes like me logo Genes that share phenotypes with PSMA2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA2 Gene

Localization for PSMA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSMA2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PSMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,IEA 17323924
GO:0000932 P-body ISS --
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA,IEA 21630459
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PSMA2: view

Pathways & Interactions for PSMA2 Gene

SuperPathways for PSMA2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMA2: view

Gene Ontology (GO) - Biological Process for PSMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PSMA2: view

No data available for SIGNOR curated interactions for PSMA2 Gene

Drugs & Compounds for PSMA2 Gene

(3) Drugs for PSMA2 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 807
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA2: view

Transcripts for PSMA2 Gene

Unigene Clusters for PSMA2 Gene

Proteasome (prosome, macropain) subunit, alpha type, 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3: -

Relevant External Links for PSMA2 Gene

GeneLoc Exon Structure for
PSMA2
ECgene alternative splicing isoforms for
PSMA2

Expression for PSMA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSMA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMA2 Gene

This gene is overexpressed in Liver, secretome (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMA2 Gene



Protein tissue co-expression partners for PSMA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMA2 Gene:

PSMA2

SOURCE GeneReport for Unigene cluster for PSMA2 Gene:

Hs.333786

Evidence on tissue expression from TISSUES for PSMA2 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Liver(4.6)
  • Pancreas(2.9)
genes like me logo Genes that share expression patterns with PSMA2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSMA2 Gene

Orthologs for PSMA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMA2 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia PSMA2 34
  • 94.44 (n)
-- 35
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PSMA2 34
  • 94.16 (n)
mouse
(Mus musculus)
Mammalia Psma2 34 16
  • 91.45 (n)
rat
(Rattus norvegicus)
Mammalia Psma2 34
  • 90.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves PSMA2 34 35
  • 84.62 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 99 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psma2 34
  • 83.48 (n)
Str.1067 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2546 34
zebrafish
(Danio rerio)
Actinopterygii si:rp71-45k5.4 35
  • 95 (a)
ManyToMany
psma2 34 35
  • 78.06 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10816 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001995 34
  • 69.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pros25 36 34 35
  • 68.24 (n)
worm
(Caenorhabditis elegans)
Secernentea pas-2 34 35
  • 62.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE8 34 35 37
  • 58.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10373g 34
  • 57.33 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL354W 34
  • 54.45 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79210 34
  • 66.09 (n)
soybean
(Glycine max)
eudicotyledons Gma.2259 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1634 34
rice
(Oryza sativa)
Liliopsida Os02g0634900 34
  • 65.09 (n)
Os.10566 34
wheat
(Triticum aestivum)
Liliopsida Ta.14373 34
corn
(Zea mays)
Liliopsida Zm.16922 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pre8 34
  • 60.59 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06764 34
  • 57.88 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15545 34
Species where no ortholog for PSMA2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA2 Gene

ENSEMBL:
Gene Tree for PSMA2 (if available)
TreeFam:
Gene Tree for PSMA2 (if available)

Paralogs for PSMA2 Gene

Paralogs for PSMA2 Gene

(8) SIMAP similar genes for PSMA2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PSMA2 Gene

genes like me logo Genes that share paralogs with PSMA2: view

Variants for PSMA2 Gene

Sequence variations from dbSNP and Humsavar for PSMA2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036278 A colorectal cancer sample
rs1000067904 -- 42,926,125(+) AGATA(A/C)CTCTG intron-variant
rs1000138292 -- 42,932,316(+) CGAGG(C/T)TTGCC nc-transcript-variant, upstream-variant-2KB
rs1000299247 -- 42,932,186(+) CAGCC(A/G/T)CACAC upstream-variant-2KB, utr-variant-5-prime
rs1000664082 -- 42,919,591(+) ATTTT(A/C)TTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMA2 Gene

Variant ID Type Subtype PubMed ID
nsv606715 CNV gain 21841781
nsv830979 CNV gain 17160897

Variation tolerance for PSMA2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA2 Gene

Disorders for PSMA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMA2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parkinson disease 15, autosomal recessive
  • autosomal recessive early-onset parkinson disease 15
- elite association - COSMIC cancer census association via MalaCards
Search PSMA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMA2

Genetic Association Database (GAD)
PSMA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA2
genes like me logo Genes that share disorders with PSMA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA2 Gene

Publications for PSMA2 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T. … Ichihara A. (Biochim. Biophys. Acta 1991) 2 3 4 64
  2. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
  3. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PMID: 16548883) Leong W.F. … Chow V.T. (Cell. Microbiol. 2006) 3 4 64
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PSMA2 Gene

Sources for PSMA2 Gene

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