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Aliases for PSMA2 Gene

Aliases for PSMA2 Gene

  • Proteasome Subunit Alpha 2 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 2 2 3
  • Multicatalytic Endopeptidase Complex Subunit C3 3 4
  • Proteasome Component C3 3 4
  • Macropain Subunit C3 3 4
  • EC 3.4.25.1 4 63
  • HC3 3 4
  • Proteasome Subunit HC3 3
  • PMSA2 3
  • PSC2 3
  • PSC3 4
  • MU 3

External Ids for PSMA2 Gene

Previous GeneCards Identifiers for PSMA2 Gene

  • GC07M042603
  • GC07M042663
  • GC07M042697
  • GC07M042729
  • GC07M042922
  • GC07M042841
  • GC07M042956

Summaries for PSMA2 Gene

Entrez Gene Summary for PSMA2 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PSMA2 Gene

PSMA2 (Proteasome Subunit Alpha 2) is a Protein Coding gene. Among its related pathways are Cell Cycle Checkpoints and Mitotic Metaphase and Anaphase. GO annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is ENSG00000256646.

UniProtKB/Swiss-Prot for PSMA2 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.

Gene Wiki entry for PSMA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA2 Gene

Genomics for PSMA2 Gene

Regulatory Elements for PSMA2 Gene

Enhancers for PSMA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSMA2 on UCSC Golden Path with GeneCards custom track

Promoters for PSMA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSMA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSMA2 Gene

Chromosome:
7
Start:
42,916,857 bp from pter
End:
42,932,223 bp from pter
Size:
15,367 bases
Orientation:
Minus strand

Genomic View for PSMA2 Gene

Genes around PSMA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA2 Gene

Proteins for PSMA2 Gene

  • Protein details for PSMA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25787-PSA2_HUMAN
    Recommended name:
    Proteasome subunit alpha type-2
    Protein Accession:
    P25787
    Secondary Accessions:
    • Q6ICS6
    • Q9BU45

    Protein attributes for PSMA2 Gene

    Size:
    234 amino acids
    Molecular mass:
    25899 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

    Three dimensional structures from OCA and Proteopedia for PSMA2 Gene

neXtProt entry for PSMA2 Gene

Proteomics data for PSMA2 Gene at MOPED

Post-translational modifications for PSMA2 Gene

  • Phosphorylated on tyrosine residues; which may be important for nuclear import.
  • Ubiquitination at Lys 39, Lys 53, Lys 70, Lys 92, Lys 165, and Lys 171
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA2 Gene

Domains & Families for PSMA2 Gene

Gene Families for PSMA2 Gene

Protein Domains for PSMA2 Gene

Suggested Antigen Peptide Sequences for PSMA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25787

UniProtKB/Swiss-Prot:

PSA2_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA2: view

Function for PSMA2 Gene

Molecular function for PSMA2 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 2,subunit HC3,25.9 kDa,would be localized in 7p13-p12 (Trachtulec)
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.
UniProtKB/Swiss-Prot Induction:
Down-regulated by antioxidants BO-653 and probucol. Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Enzyme Numbers (IUBMB) for PSMA2 Gene

genes like me logo Genes that share phenotypes with PSMA2: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA2 Gene

Localization for PSMA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA2 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA2 Gene COMPARTMENTS Subcellular localization image for PSMA2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PSMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PSMA2: view

Pathways & Interactions for PSMA2 Gene

SuperPathways for PSMA2 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMA2: view

Gene Ontology (GO) - Biological Process for PSMA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMA2: view

No data available for SIGNOR curated interactions for PSMA2 Gene

Drugs & Compounds for PSMA2 Gene

(3) Drugs for PSMA2 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 776
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA2: view

Transcripts for PSMA2 Gene

Unigene Clusters for PSMA2 Gene

Proteasome (prosome, macropain) subunit, alpha type, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3: -

Relevant External Links for PSMA2 Gene

GeneLoc Exon Structure for
PSMA2
ECgene alternative splicing isoforms for
PSMA2

Expression for PSMA2 Gene

mRNA expression in normal human tissues for PSMA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PSMA2 Gene

This gene is overexpressed in Liver, secretome (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMA2 Gene



SOURCE GeneReport for Unigene cluster for PSMA2 Gene Hs.333786

genes like me logo Genes that share expression patterns with PSMA2: view

Protein tissue co-expression partners for PSMA2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMA2 Gene

Orthologs for PSMA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMA2 35
  • 94.16 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia PSMA2 35
  • 94.44 (n)
  • 100 (a)
-- 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Psma2 35
  • 91.45 (n)
  • 99.57 (a)
Psma2 16
chimpanzee
(Pan troglodytes)
Mammalia PSMA2 35
  • 100 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Psma2 35
  • 90.88 (n)
  • 99.57 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves PSMA2 35
  • 84.62 (n)
  • 98.29 (a)
PSMA2 36
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psma2 35
  • 83.48 (n)
  • 95.73 (a)
Str.1067 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2546 35
zebrafish
(Danio rerio)
Actinopterygii psma2 35
  • 78.06 (n)
  • 95.3 (a)
psma2 36
  • 95 (a)
ManyToMany
si:rp71-45k5.4 36
  • 95 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10816 35
fruit fly
(Drosophila melanogaster)
Insecta Pros25 37
  • 78 (a)
Pros25 35
  • 68.24 (n)
  • 78.11 (a)
Pros25 36
  • 78 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001995 35
  • 69.24 (n)
  • 82.4 (a)
worm
(Caenorhabditis elegans)
Secernentea pas-2 35
  • 62.96 (n)
  • 67.56 (a)
pas-2 36
  • 65 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL354W 35
  • 54.45 (n)
  • 59.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10373g 35
  • 57.33 (n)
  • 62.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE8 35
  • 58.33 (n)
  • 62.5 (a)
PRE8 36
  • 57 (a)
OneToMany
PRE8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79210 35
  • 66.09 (n)
  • 66.09 (a)
soybean
(Glycine max)
eudicotyledons Gma.2259 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1634 35
rice
(Oryza sativa)
Liliopsida Os.10566 35
Os02g0634900 35
  • 65.09 (n)
  • 66.09 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14373 35
corn
(Zea mays)
Liliopsida Zm.16922 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15545 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06764 35
  • 57.88 (n)
  • 66.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pre8 35
  • 60.59 (n)
  • 65.78 (a)
Species with no ortholog for PSMA2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA2 Gene

ENSEMBL:
Gene Tree for PSMA2 (if available)
TreeFam:
Gene Tree for PSMA2 (if available)

Paralogs for PSMA2 Gene

Paralogs for PSMA2 Gene

(8) SIMAP similar genes for PSMA2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PSMA2 Gene

genes like me logo Genes that share paralogs with PSMA2: view

Variants for PSMA2 Gene

Sequence variations from dbSNP and Humsavar for PSMA2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036278 A colorectal cancer sample
rs774085 -- 42,930,172(-) TAAAA(A/G)GAAAA intron-variant
rs774086 -- 42,930,147(-) CTCTC(A/G)TAATC intron-variant
rs1060304 -- 42,917,334(-) GACTA(C/T)ATTGC utr-variant-3-prime
rs13233636 -- 42,926,645(+) CTCAG(G/T)TGCTA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PSMA2 Gene

Variant ID Type Subtype PubMed ID
nsv830979 CNV Gain 17160897

Variation tolerance for PSMA2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSMA2 Gene

Disorders for PSMA2 Gene

Relevant External Links for PSMA2

Genetic Association Database (GAD)
PSMA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA2

No disorders were found for PSMA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMA2 Gene

Publications for PSMA2 Gene

  1. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T. … Ichihara A. (Biochim. Biophys. Acta 1991) 2 3 4 67
  2. The primary structures of four subunits of the human, high-molecular- weight proteinase, macropain (proteasome), are distinct but homologous. (PMID: 1888762) DeMartino G.N. … Slaughter C.A. (Biochim. Biophys. Acta 1991) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for PSMA2 Gene

Sources for PSMA2 Gene

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