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Aliases for PSMA1 Gene

Aliases for PSMA1 Gene

  • Proteasome Subunit Alpha 1 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 1 2 3
  • Multicatalytic Endopeptidase Complex Subunit C2 3 4
  • Proteasome Component C2 3 4
  • 30 KDa Prosomal Protein 3 4
  • Macropain Subunit C2 3 4
  • Proteasome Nu Chain 3 4
  • EC 3.4.25.1 4 61
  • PROS-30 3 4
  • PROS30 3 4
  • HC2 3 4
  • NU 3 4
  • Epididymis Secretory Protein Li 275 3
  • Proteasome Subunit, Alpha-Type, 1 3
  • Testicular Tissue Protein Li 150 3
  • Proteasome Subunit Alpha Type-1 3
  • Proteasome Subunit Nu 3
  • Macropain Subunit Nu 3
  • Protein P30-33K 3
  • HEL-S-275 3
  • PSC2 4

External Ids for PSMA1 Gene

Previous GeneCards Identifiers for PSMA1 Gene

  • GC11M015706
  • GC11M015274
  • GC11M014565
  • GC11M014490
  • GC11M014482
  • GC11M014207

Summaries for PSMA1 Gene

Entrez Gene Summary for PSMA1 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

GeneCards Summary for PSMA1 Gene

PSMA1 (Proteasome Subunit Alpha 1) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include RNA binding and threonine-type endopeptidase activity. An important paralog of this gene is ENSG00000256206.

UniProtKB/Swiss-Prot for PSMA1 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity).

Gene Wiki entry for PSMA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA1 Gene

Genomics for PSMA1 Gene

Regulatory Elements for PSMA1 Gene

Enhancers for PSMA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F014536 1.7 FANTOM5 Ensembl ENCODE 13.3 +105.6 105635 2.4 CTCF ZNF654 NR2F1 TRIM22 ZNF384 DPF2 RAD21 ARID1B GATA3 JUND PSMA1 PDE3B COPB1 ENSG00000256206 PIR39085
GH11F014543 0.3 FANTOM5 13.1 +100.2 100154 0.2 PSMA1 PDE3B ENSG00000256206 PIR39085
GH11F014539 1.3 FANTOM5 Ensembl ENCODE 12.1 +102.2 102235 3.6 NFIA CEBPB PPARG RAD21 NR2F2 YY1 SMARCA4 ATF3 CEBPA HNF4G PDE3B PSMA1 COPB1 RRAS2 ENSG00000256206 PIR39085
GH11F014611 0.9 Ensembl ENCODE 11.9 +31.1 31135 2.2 TFAP4 TFE3 SAP130 L3MBTL2 MLX FOXA3 PPARG ZNF644 ZBTB33 HOMEZ PDE3B PSMA1 PIR39085
GH11F014544 1.3 Ensembl ENCODE 11.9 +98.9 98935 1.4 BACH1 EBF1 RAD21 YY1 ZNF316 CBX5 ETV6 TRIM24 NFE2 CREM PDE3B PSMA1 ENSG00000256206 PIR39085
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSMA1 on UCSC Golden Path with GeneCards custom track

Promoters for PSMA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000559049 -1765 5201 CREB3L1 MLX ARID4B FEZF1 DMAP1 CBX5 REST KAT8 MEF2D CBX8

Genomic Location for PSMA1 Gene

Chromosome:
11
Start:
14,504,874 bp from pter
End:
14,643,635 bp from pter
Size:
138,762 bases
Orientation:
Minus strand

Genomic View for PSMA1 Gene

Genes around PSMA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA1 Gene

Proteins for PSMA1 Gene

  • Protein details for PSMA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25786-PSA1_HUMAN
    Recommended name:
    Proteasome subunit alpha type-1
    Protein Accession:
    P25786
    Secondary Accessions:
    • A8K400
    • Q53YE8
    • Q9BRV9

    Protein attributes for PSMA1 Gene

    Size:
    263 amino acids
    Molecular mass:
    29556 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with bacterial lipopolysaccharide (LPS) (By similarity). Interacts with NOTCH3.

    Three dimensional structures from OCA and Proteopedia for PSMA1 Gene

    Alternative splice isoforms for PSMA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA1 Gene

Post-translational modifications for PSMA1 Gene

  • Ubiquitination at Lys 30, Lys 50, Lys 115, Lys 189, Lys 208, Lys 243, and Lys 256
  • Glycosylation at Ser 110
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for PSMA1

Domains & Families for PSMA1 Gene

Gene Families for PSMA1 Gene

Suggested Antigen Peptide Sequences for PSMA1 Gene

Graphical View of Domain Structure for InterPro Entry

P25786

UniProtKB/Swiss-Prot:

PSA1_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA1: view

Function for PSMA1 Gene

Molecular function for PSMA1 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 1,subunit Pros30,30kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced in breast cancer tissue (at protein level). Up-regulated in liver tumor tissues.

Enzyme Numbers (IUBMB) for PSMA1 Gene

Gene Ontology (GO) - Molecular Function for PSMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IEA --
GO:0003723 RNA binding TAS 7681138
GO:0004175 endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12376572
genes like me logo Genes that share ontologies with PSMA1: view
genes like me logo Genes that share phenotypes with PSMA1: view

Animal Model Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA1 Gene

Localization for PSMA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA1 Gene COMPARTMENTS Subcellular localization image for PSMA1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PSMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA,TAS 17323924
GO:0005634 nucleus IDA,TAS 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with PSMA1: view

Pathways & Interactions for PSMA1 Gene

SuperPathways for PSMA1 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Chks in Checkpoint Regulation
4 HIV Life Cycle
.45
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with PSMA1: view

Gene Ontology (GO) - Biological Process for PSMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with PSMA1: view

No data available for SIGNOR curated interactions for PSMA1 Gene

Drugs & Compounds for PSMA1 Gene

(17) Drugs for PSMA1 Gene - From: DrugBank, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 794
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
AM 114 Pharma 20S proteasome inhibitor 0
Bortezomib (PS-341) Pharma Proteasome Inhibitor 0

(14) ApexBio Compounds for PSMA1 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
Bortezomib (PS-341) Proteasome Inhibitor 179324-69-7
Carfilzomib (PR-171) Proteasome inhibitor,epoxomicin analog 868540-17-4
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
CEP-18770 Proteasome inhibitor 847499-27-8
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
Epoxomicin Proteasome inhibitor 134381-21-8
MG-132 Proteasome inhibitor, Cell permeable, reversible 133407-82-6
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
MLN9708 Proteasome inhibitor 1201902-80-8
ONX-0914 (PR-957) Immunoproteasome inhibitor,potent and selective 960374-59-8
Oprozomib (ONX-0912) Proteasome inhibitor 935888-69-0
PI-1840 Chymotrypsin-like (CT-L) inhibitor 1401223-22-0
PSI Proteasome inhibitor 158442-41-2
genes like me logo Genes that share compounds with PSMA1: view

Transcripts for PSMA1 Gene

Unigene Clusters for PSMA1 Gene

Proteasome (prosome, macropain) subunit, alpha type, 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7: - -
SP8: -
SP9: -

Relevant External Links for PSMA1 Gene

GeneLoc Exon Structure for
PSMA1
ECgene alternative splicing isoforms for
PSMA1

Expression for PSMA1 Gene

mRNA expression in normal human tissues for PSMA1 Gene

Protein differential expression in normal tissues from HIPED for PSMA1 Gene

This gene is overexpressed in Liver, secretome (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMA1 Gene



Protein tissue co-expression partners for PSMA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMA1 Gene:

PSMA1

SOURCE GeneReport for Unigene cluster for PSMA1 Gene:

Hs.102798
genes like me logo Genes that share expression patterns with PSMA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMA1 Gene

Orthologs for PSMA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMA1 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
ManyToMany
-- 35
  • 97 (a)
ManyToMany
-- 35
  • 96 (a)
ManyToMany
-- 35
  • 95 (a)
ManyToMany
PSMA1 34
  • 94.55 (n)
-- 35
  • 90 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 96 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PSMA1 34 35
  • 94.17 (n)
mouse
(Mus musculus)
Mammalia Psma1 34 16 35
  • 92.02 (n)
rat
(Rattus norvegicus)
Mammalia Psma1 34
  • 90.37 (n)
chicken
(Gallus gallus)
Aves PSMA1 34 35
  • 83.2 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5957 34
zebrafish
(Danio rerio)
Actinopterygii psma1 34 35
  • 74.46 (n)
wufc17c09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8498 34
fruit fly
(Drosophila melanogaster)
Insecta Pros35 36 35
  • 58 (a)
Prosalpha6T 36 34 35
  • 54.35 (n)
worm
(Caenorhabditis elegans)
Secernentea pas-6 34 35
  • 55.34 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE5 34 35
  • 56.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10153g 34
  • 56.18 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL336W 34
  • 53.02 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PAF2 34
  • 54.5 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6955 34
rice
(Oryza sativa)
Liliopsida Os02g0133800 34
  • 54.38 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.2240 34
wheat
(Triticum aestivum)
Liliopsida Ta.18932 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5765 35
  • 66 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6G10.04c 34
  • 57.14 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06712 34
  • 51.52 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4798 34
Species where no ortholog for PSMA1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA1 Gene

ENSEMBL:
Gene Tree for PSMA1 (if available)
TreeFam:
Gene Tree for PSMA1 (if available)

Paralogs for PSMA1 Gene

Paralogs for PSMA1 Gene

(7) SIMAP similar genes for PSMA1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMA1 Gene

genes like me logo Genes that share paralogs with PSMA1: view

Variants for PSMA1 Gene

Sequence variations from dbSNP and Humsavar for PSMA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10160436 -- 14,548,567(+) gacat(C/T)atatt intron-variant
rs10160597 -- 14,582,446(+) CACAG(A/G)GCAAG intron-variant
rs10160675 -- 14,528,714(+) aagat(C/T)cacaa intron-variant
rs10458874 -- 14,637,965(+) GGAGG(A/G)TAAGG intron-variant
rs10500802 -- 14,615,845(+) CCAGG(G/T)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMA1 Gene

Variant ID Type Subtype PubMed ID
esv3305305 CNV mobile element insertion 20981092
esv3324169 CNV insertion 20981092
esv3578250 CNV gain 25503493
esv3625423 CNV loss 21293372
esv3625424 CNV loss 21293372
nsv1048243 CNV gain 25217958
nsv517985 CNV loss 19592680
nsv518508 CNV loss 19592680
nsv7685 CNV insertion 18451855
nsv951312 CNV deletion 24416366

Variation tolerance for PSMA1 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA1 Gene

Disorders for PSMA1 Gene

Relevant External Links for PSMA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA1

No disorders were found for PSMA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSMA1 Gene

Publications for PSMA1 Gene

  1. Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes. (PMID: 1398136) Silva-Pereira I. … Scherrer K. (Gene 1992) 2 3 4 64
  2. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T. … Ichihara A. (Biochim. Biophys. Acta 1991) 2 3 4 64
  3. Conserved signal peptide of Notch3 inhibits interaction with proteasome. (PMID: 17292860) Zhang Y. … Wang M.M. (Biochem. Biophys. Res. Commun. 2007) 3 4 64
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PSMA1 Gene

Sources for PSMA1 Gene

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