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Aliases for PSMA1 Gene

Aliases for PSMA1 Gene

  • Proteasome Subunit Alpha 1 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 1 2 3
  • Multicatalytic Endopeptidase Complex Subunit C2 3 4
  • Proteasome Component C2 3 4
  • 30 KDa Prosomal Protein 3 4
  • Macropain Subunit C2 3 4
  • Proteasome Nu Chain 3 4
  • EC 3.4.25.1 4 61
  • PROS-30 3 4
  • PROS30 3 4
  • HC2 3 4
  • NU 3 4
  • Epididymis Secretory Protein Li 275 3
  • Proteasome Subunit, Alpha-Type, 1 3
  • Testicular Tissue Protein Li 150 3
  • Proteasome Subunit Alpha Type-1 3
  • Proteasome Subunit Nu 3
  • Macropain Subunit Nu 3
  • Protein P30-33K 3
  • HEL-S-275 3
  • PSC2 4

External Ids for PSMA1 Gene

Previous GeneCards Identifiers for PSMA1 Gene

  • GC11M015706
  • GC11M015274
  • GC11M014565
  • GC11M014490
  • GC11M014482
  • GC11M014207

Summaries for PSMA1 Gene

Entrez Gene Summary for PSMA1 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

GeneCards Summary for PSMA1 Gene

PSMA1 (Proteasome Subunit Alpha 1) is a Protein Coding gene. Diseases associated with PSMA1 include Thrombophilia Due To Heparin Cofactor Ii Deficiency. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include RNA binding and threonine-type endopeptidase activity. An important paralog of this gene is ENSG00000256206.

UniProtKB/Swiss-Prot for PSMA1 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity).

Gene Wiki entry for PSMA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA1 Gene

Genomics for PSMA1 Gene

Regulatory Elements for PSMA1 Gene

Enhancers for PSMA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PSMA1 on UCSC Golden Path with GeneCards custom track

Promoters for PSMA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PSMA1 Gene

Chromosome:
11
Start:
14,504,874 bp from pter
End:
14,643,635 bp from pter
Size:
138,762 bases
Orientation:
Minus strand

Genomic View for PSMA1 Gene

Genes around PSMA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA1 Gene

Proteins for PSMA1 Gene

  • Protein details for PSMA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25786-PSA1_HUMAN
    Recommended name:
    Proteasome subunit alpha type-1
    Protein Accession:
    P25786
    Secondary Accessions:
    • A8K400
    • Q53YE8
    • Q9BRV9

    Protein attributes for PSMA1 Gene

    Size:
    263 amino acids
    Molecular mass:
    29556 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with bacterial lipopolysaccharide (LPS) (By similarity). Interacts with NOTCH3.

    Three dimensional structures from OCA and Proteopedia for PSMA1 Gene

    Alternative splice isoforms for PSMA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA1 Gene

Post-translational modifications for PSMA1 Gene

  • Ubiquitination at Lys 30, Lys 50, Lys 115, Lys 189, Lys 208, Lys 243, and Lys 256
  • Glycosylation at Ser 110
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA1 Gene

Domains & Families for PSMA1 Gene

Gene Families for PSMA1 Gene

Protein Domains for PSMA1 Gene

Suggested Antigen Peptide Sequences for PSMA1 Gene

Graphical View of Domain Structure for InterPro Entry

P25786

UniProtKB/Swiss-Prot:

PSA1_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA1: view

Function for PSMA1 Gene

Molecular function for PSMA1 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 1,subunit Pros30,30kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced in breast cancer tissue (at protein level). Up-regulated in liver tumor tissues.

Enzyme Numbers (IUBMB) for PSMA1 Gene

Gene Ontology (GO) - Molecular Function for PSMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7681138
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12376572
genes like me logo Genes that share ontologies with PSMA1: view
genes like me logo Genes that share phenotypes with PSMA1: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA1 Gene

Localization for PSMA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA1 Gene COMPARTMENTS Subcellular localization image for PSMA1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PSMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSMA1: view

Pathways & Interactions for PSMA1 Gene

SuperPathways for PSMA1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMA1: view

Gene Ontology (GO) - Biological Process for PSMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
genes like me logo Genes that share ontologies with PSMA1: view

No data available for SIGNOR curated interactions for PSMA1 Gene

Drugs & Compounds for PSMA1 Gene

(17) Drugs for PSMA1 Gene - From: DrugBank, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Investigational Pharma inhibitor, other Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 783
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
AM 114 Pharma 20S proteasome inhibitor 0
Bortezomib (PS-341) Pharma Proteasome Inhibitor 0

(14) ApexBio Compounds for PSMA1 Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
Bortezomib (PS-341) Proteasome Inhibitor 179324-69-7
Carfilzomib (PR-171) Proteasome inhibitor,epoxomicin analog 868540-17-4
Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent 34157-83-0
CEP-18770 Proteasome inhibitor 847499-27-8
Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative 126463-64-7
Epoxomicin Proteasome inhibitor 134381-21-8
MG-132 Proteasome inhibitor, Cell permeable, reversible 133407-82-6
MLN2238 β5 site of the 20S proteasome inhibitor 1072833-77-2
MLN9708 Proteasome inhibitor 1201902-80-8
ONX-0914 (PR-957) Immunoproteasome inhibitor,potent and selective 960374-59-8
Oprozomib (ONX-0912) Proteasome inhibitor 935888-69-0
PI-1840 Chymotrypsin-like (CT-L) inhibitor 1401223-22-0
PSI Proteasome inhibitor 158442-41-2
genes like me logo Genes that share compounds with PSMA1: view

Transcripts for PSMA1 Gene

Unigene Clusters for PSMA1 Gene

Proteasome (prosome, macropain) subunit, alpha type, 1:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7: - -
SP8: -
SP9: -

Relevant External Links for PSMA1 Gene

GeneLoc Exon Structure for
PSMA1
ECgene alternative splicing isoforms for
PSMA1

Expression for PSMA1 Gene

mRNA expression in normal human tissues for PSMA1 Gene

Protein differential expression in normal tissues from HIPED for PSMA1 Gene

This gene is overexpressed in Liver, secretome (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSMA1 Gene



Protein tissue co-expression partners for PSMA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSMA1 Gene:

PSMA1

SOURCE GeneReport for Unigene cluster for PSMA1 Gene:

Hs.102798
genes like me logo Genes that share expression patterns with PSMA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMA1 Gene

Orthologs for PSMA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMA1 34
  • 94.17 (n)
  • 99.62 (a)
PSMA1 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PSMA1 34
  • 94.55 (n)
  • 99.62 (a)
-- 35
  • 95 (a)
ManyToMany
-- 35
  • 96 (a)
ManyToMany
-- 35
  • 98 (a)
ManyToMany
-- 35
  • 97 (a)
ManyToMany
-- 35
  • 90 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psma1 34
  • 92.02 (n)
  • 98.1 (a)
Psma1 16
Psma1 35
  • 98 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PSMA1 34
  • 99.62 (n)
  • 100 (a)
PSMA1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psma1 34
  • 90.37 (n)
  • 97.72 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 96 (a)
OneToMany
chicken
(Gallus gallus)
Aves PSMA1 34
  • 83.2 (n)
  • 95.67 (a)
PSMA1 35
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5957 34
zebrafish
(Danio rerio)
Actinopterygii psma1 34
  • 74.46 (n)
  • 92.34 (a)
wufc17c09 34
psma1 35
  • 91 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8498 34
fruit fly
(Drosophila melanogaster)
Insecta Pros35 36
  • 58 (a)
Prosalpha6T 36
  • 50 (a)
Prosalpha6T 34
  • 54.35 (n)
  • 53.82 (a)
Pros35 35
  • 51 (a)
ManyToMany
Prosalpha6T 35
  • 47 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pas-6 34
  • 55.34 (n)
  • 54.05 (a)
pas-6 35
  • 53 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL336W 34
  • 53.02 (n)
  • 53.45 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10153g 34
  • 56.18 (n)
  • 54.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE5 34
  • 56.32 (n)
  • 53.45 (a)
PRE5 35
  • 53 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PAF2 34
  • 54.5 (n)
  • 48.41 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6955 34
barley
(Hordeum vulgare)
Liliopsida Hv.2240 34
rice
(Oryza sativa)
Liliopsida Os02g0133800 34
  • 54.38 (n)
  • 51.76 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.18932 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4798 34
bread mold
(Neurospora crassa)
Ascomycetes NCU06712 34
  • 51.52 (n)
  • 54.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6G10.04c 34
  • 57.14 (n)
  • 55.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5765 35
  • 66 (a)
OneToMany
Species where no ortholog for PSMA1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA1 Gene

ENSEMBL:
Gene Tree for PSMA1 (if available)
TreeFam:
Gene Tree for PSMA1 (if available)

Paralogs for PSMA1 Gene

Paralogs for PSMA1 Gene

(7) SIMAP similar genes for PSMA1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMA1 Gene

genes like me logo Genes that share paralogs with PSMA1: view

Variants for PSMA1 Gene

Sequence variations from dbSNP and Humsavar for PSMA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17850016 - 14,517,920(+) TCAGA(A/C)CAACT reference, missense
rs1051046 -- 14,505,142(-) CAGGC(A/C)CCACA utr-variant-3-prime
rs1357332 -- 14,618,570(-) ATGAC(A/C)ATTCC intron-variant
rs1375953 -- 14,580,307(-) taaga(C/T)gtgtt intron-variant
rs1375954 -- 14,559,617(-) ATGTG(A/C)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMA1 Gene

Variant ID Type Subtype PubMed ID
esv3305305 CNV mobile element insertion 20981092
esv3324169 CNV insertion 20981092
esv3578250 CNV gain 25503493
esv3625423 CNV loss 21293372
esv3625424 CNV loss 21293372
nsv1048243 CNV gain 25217958
nsv517985 CNV loss 19592680
nsv518508 CNV loss 19592680
nsv7685 CNV insertion 18451855
nsv951312 CNV deletion 24416366

Variation tolerance for PSMA1 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSMA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA1 Gene

Disorders for PSMA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMA1 Gene - From: OMIM

Disorder Aliases PubMed IDs
thrombophilia due to heparin cofactor ii deficiency
  • thrombophilia due to heparin cofactor 2 deficiency
- elite association - COSMIC cancer census association via MalaCards
Search PSMA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA1
genes like me logo Genes that share disorders with PSMA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA1 Gene

Publications for PSMA1 Gene

  1. Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes. (PMID: 1398136) Silva-Pereira I. … Scherrer K. (Gene 1992) 2 3 4 65
  2. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T. … Ichihara A. (Biochim. Biophys. Acta 1991) 2 3 4 65
  3. Conserved signal peptide of Notch3 inhibits interaction with proteasome. (PMID: 17292860) Zhang Y. … Wang M.M. (Biochem. Biophys. Res. Commun. 2007) 3 4 65
  4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PMID: 17323924) Wang X. … Huang L. (Biochemistry 2007) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for PSMA1 Gene

Sources for PSMA1 Gene

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