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Aliases for PSMA1 Gene

Aliases for PSMA1 Gene

  • Proteasome Subunit Alpha 1 2 3 5
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 1 2 3
  • Multicatalytic Endopeptidase Complex Subunit C2 3 4
  • Proteasome Component C2 3 4
  • 30 KDa Prosomal Protein 3 4
  • Macropain Subunit C2 3 4
  • Proteasome Nu Chain 3 4
  • EC 3.4.25.1 4 63
  • PROS-30 3 4
  • PROS30 3 4
  • HC2 3 4
  • NU 3 4
  • Epididymis Secretory Protein Li 275 3
  • Proteasome Subunit, Alpha-Type, 1 3
  • Testicular Tissue Protein Li 150 3
  • Proteasome Subunit Nu 3
  • Macropain Subunit Nu 3
  • Protein P30-33K 3
  • HEL-S-275 3
  • PSC2 4

External Ids for PSMA1 Gene

Previous GeneCards Identifiers for PSMA1 Gene

  • GC11M015706
  • GC11M015274
  • GC11M014565
  • GC11M014490
  • GC11M014482
  • GC11M014207

Summaries for PSMA1 Gene

Entrez Gene Summary for PSMA1 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

GeneCards Summary for PSMA1 Gene

PSMA1 (Proteasome Subunit Alpha 1) is a Protein Coding gene. Diseases associated with PSMA1 include thrombophilia due to heparin cofactor ii deficiency. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include RNA binding and threonine-type endopeptidase activity. An important paralog of this gene is ENSG00000256206.

UniProtKB/Swiss-Prot for PSMA1 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity).

Gene Wiki entry for PSMA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA1 Gene

Genomics for PSMA1 Gene

Regulatory Elements for PSMA1 Gene

Genomic Location for PSMA1 Gene

Chromosome:
11
Start:
14,504,874 bp from pter
End:
14,643,635 bp from pter
Size:
138,762 bases
Orientation:
Minus strand

Genomic View for PSMA1 Gene

Genes around PSMA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSMA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSMA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA1 Gene

Proteins for PSMA1 Gene

  • Protein details for PSMA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25786-PSA1_HUMAN
    Recommended name:
    Proteasome subunit alpha type-1
    Protein Accession:
    P25786
    Secondary Accessions:
    • A8K400
    • Q53YE8
    • Q9BRV9

    Protein attributes for PSMA1 Gene

    Size:
    263 amino acids
    Molecular mass:
    29556 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with bacterial lipopolysaccharide (LPS) (By similarity). Interacts with NOTCH3.

    Three dimensional structures from OCA and Proteopedia for PSMA1 Gene

    Alternative splice isoforms for PSMA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA1 Gene

Proteomics data for PSMA1 Gene at MOPED

Post-translational modifications for PSMA1 Gene

  • Ubiquitination at Lys 30, Lys 50, Lys 115, Lys 189, Lys 208, Lys 243, and Lys 256
  • Glycosylation at Ser 110
  • Modification sites at PhosphoSitePlus

Other Protein References for PSMA1 Gene

Antibody Products

Domains & Families for PSMA1 Gene

Gene Families for PSMA1 Gene

Protein Domains for PSMA1 Gene

Suggested Antigen Peptide Sequences for PSMA1 Gene

Graphical View of Domain Structure for InterPro Entry

P25786

UniProtKB/Swiss-Prot:

PSA1_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA1: view

Function for PSMA1 Gene

Molecular function for PSMA1 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 1,subunit Pros30,30kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced in breast cancer tissue (at protein level). Up-regulated in liver tumor tissues.

Enzyme Numbers (IUBMB) for PSMA1 Gene

genes like me logo Genes that share phenotypes with PSMA1: view

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA1 Gene

Localization for PSMA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA1 Gene COMPARTMENTS Subcellular localization image for PSMA1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PSMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PSMA1: view

Pathways & Interactions for PSMA1 Gene

SuperPathways for PSMA1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin-3, 5 and GM-CSF signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.48
5 Immune System
genes like me logo Genes that share pathways with PSMA1: view

Gene Ontology (GO) - Biological Process for PSMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with PSMA1: view

No data available for SIGNOR curated interactions for PSMA1 Gene

Drugs & Compounds for PSMA1 Gene

(3) Drugs for PSMA1 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 769
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA1: view

Transcripts for PSMA1 Gene

Unigene Clusters for PSMA1 Gene

Proteasome (prosome, macropain) subunit, alpha type, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7: - -
SP8: -
SP9: -

Relevant External Links for PSMA1 Gene

GeneLoc Exon Structure for
PSMA1
ECgene alternative splicing isoforms for
PSMA1

Expression for PSMA1 Gene

mRNA expression in normal human tissues for PSMA1 Gene

Protein differential expression in normal tissues from HIPED for PSMA1 Gene

This gene is overexpressed in Liver, secretome (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMA1 Gene



SOURCE GeneReport for Unigene cluster for PSMA1 Gene Hs.102798

genes like me logo Genes that share expression patterns with PSMA1: view

Protein tissue co-expression partners for PSMA1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PSMA1 Gene

Orthologs for PSMA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSMA1 36
  • 100 (a)
OneToOne
PSMA1 35
  • 99.62 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PSMA1 36
  • 99 (a)
OneToMany
PSMA1 35
  • 94.17 (n)
  • 99.62 (a)
dog
(Canis familiaris)
Mammalia PSMA1 35
  • 94.55 (n)
  • 99.62 (a)
-- 36
  • 95 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
-- 36
  • 98 (a)
ManyToMany
-- 36
  • 97 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psma1 36
  • 98 (a)
OneToMany
Psma1 35
  • 92.02 (n)
  • 98.1 (a)
Psma1 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Psma1 35
  • 90.37 (n)
  • 97.72 (a)
chicken
(Gallus gallus)
Aves PSMA1 35
  • 83.2 (n)
  • 95.67 (a)
PSMA1 36
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5957 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8498 35
zebrafish
(Danio rerio)
Actinopterygii psma1 35
  • 74.46 (n)
  • 92.34 (a)
wufc17c09 35
psma1 36
  • 91 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pros35 37
  • 58 (a)
Prosalpha6T 37
  • 50 (a)
Prosalpha6T 35
  • 54.35 (n)
  • 53.82 (a)
Pros35 36
  • 51 (a)
ManyToMany
Prosalpha6T 36
  • 47 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pas-6 36
  • 53 (a)
OneToMany
pas-6 35
  • 55.34 (n)
  • 54.05 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL336W 35
  • 53.02 (n)
  • 53.45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE5 35
  • 56.32 (n)
  • 53.45 (a)
PRE5 36
  • 53 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10153g 35
  • 56.18 (n)
  • 54.31 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6955 35
thale cress
(Arabidopsis thaliana)
eudicotyledons PAF2 35
  • 54.5 (n)
  • 48.41 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2240 35
rice
(Oryza sativa)
Liliopsida Os02g0133800 35
  • 54.38 (n)
  • 51.76 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.18932 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06712 35
  • 51.52 (n)
  • 54.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6G10.04c 35
  • 57.14 (n)
  • 55.16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4798 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5765 36
  • 66 (a)
OneToMany
Species with no ortholog for PSMA1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA1 Gene

ENSEMBL:
Gene Tree for PSMA1 (if available)
TreeFam:
Gene Tree for PSMA1 (if available)

Paralogs for PSMA1 Gene

Paralogs for PSMA1 Gene

(7) SIMAP similar genes for PSMA1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PSMA1 Gene

genes like me logo Genes that share paralogs with PSMA1: view

Variants for PSMA1 Gene

Sequence variations from dbSNP and Humsavar for PSMA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs939968 -- 14,608,134(-) GCCTC(A/G)GTGAT intron-variant
rs896029 -- 14,583,336(-) ACAAA(C/T)GGCCT intron-variant
rs1403247 -- 14,611,024(-) TGTTG(G/T)ATGTT utr-variant-5-prime
rs1473350 -- 14,579,509(-) TATTT(A/G)AAAAA intron-variant
rs1608166 -- 14,604,968(-) tcaac(C/T)tagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMA1 Gene

Variant ID Type Subtype PubMed ID
nsv7685 CNV Insertion 18451855
nsv518508 CNV Loss 19592680
nsv517985 CNV Loss 19592680
esv269583 CNV Insertion 20981092

Variation tolerance for PSMA1 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA1 Gene

HapMap Linkage Disequilibrium report
PSMA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA1 Gene

Disorders for PSMA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSMA1 Gene - From: OMIM

Disorder Aliases PubMed IDs
thrombophilia due to heparin cofactor ii deficiency
  • thrombophilia due to heparin cofactor 2 deficiency
- elite association - COSMIC cancer census association via MalaCards
Search PSMA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA1
genes like me logo Genes that share disorders with PSMA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA1 Gene

Publications for PSMA1 Gene

  1. Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes. (PMID: 1398136) Silva-Pereira I. … Scherrer K. (Gene 1992) 2 3 4 67
  2. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). (PMID: 2025653) Tamura T. … Ichihara A. (Biochim. Biophys. Acta 1991) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PSMA1 Gene

Sources for PSMA1 Gene

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