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Aliases for PSKH2 Gene

Aliases for PSKH2 Gene

  • Protein Serine Kinase H2 2 3 4 5
  • EC 4 63
  • PSK-H2 3 4
  • Serine/Threonine Kinase PSKH2 3
  • EC 2.7.11 63

External Ids for PSKH2 Gene

Previous GeneCards Identifiers for PSKH2 Gene

  • GC08M085649
  • GC08M086792
  • GC08M087017
  • GC08M087129
  • GC08M082270
  • GC08M087060

Summaries for PSKH2 Gene

GeneCards Summary for PSKH2 Gene

PSKH2 (Protein Serine Kinase H2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMK2D.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSKH2 Gene

Genomics for PSKH2 Gene

Regulatory Elements for PSKH2 Gene

Genomic Location for PSKH2 Gene

86,047,109 bp from pter
86,088,621 bp from pter
41,513 bases
Minus strand

Genomic View for PSKH2 Gene

Genes around PSKH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSKH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSKH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSKH2 Gene

Proteins for PSKH2 Gene

  • Protein details for PSKH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase H2
    Protein Accession:
    Secondary Accessions:
    • A0AV22

    Protein attributes for PSKH2 Gene

    385 amino acids
    Molecular mass:
    43027 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSKH2 Gene

Proteomics data for PSKH2 Gene at MOPED

Post-translational modifications for PSKH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSKH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSKH2 Gene

Gene Families for PSKH2 Gene

Suggested Antigen Peptide Sequences for PSKH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with PSKH2: view

Function for PSKH2 Gene

Molecular function for PSKH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for PSKH2 Gene

Gene Ontology (GO) - Molecular Function for PSKH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PSKH2: view
genes like me logo Genes that share phenotypes with PSKH2: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PSKH2 Gene

Localization for PSKH2 Gene

Subcellular locations from

Jensen Localization Image for PSKH2 Gene COMPARTMENTS Subcellular localization image for PSKH2 gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PSKH2 Gene

Pathways & Interactions for PSKH2 Gene

SuperPathways for PSKH2 Gene

No Data Available

Interacting Proteins for PSKH2 Gene

Gene Ontology (GO) - Biological Process for PSKH2 Gene


No data available for Pathways by source and SIGNOR curated interactions for PSKH2 Gene

Drugs & Compounds for PSKH2 Gene

(1) Drugs for PSKH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for PSKH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PSKH2: view

Transcripts for PSKH2 Gene

mRNA/cDNA for PSKH2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSKH2 Gene

Protein serine kinase H2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSKH2 Gene

No ASD Table

Relevant External Links for PSKH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSKH2 Gene

mRNA expression in normal human tissues for PSKH2 Gene

mRNA differential expression in normal tissues according to GTEx for PSKH2 Gene

This gene is overexpressed in Testis (x21.3), Kidney - Cortex (x17.1), Brain - Putamen (basal ganglia) (x5.2), Brain - Hippocampus (x5.1), and Brain - Hypothalamus (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSKH2 Gene

SOURCE GeneReport for Unigene cluster for PSKH2 Gene Hs.680136

genes like me logo Genes that share expression patterns with PSKH2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PSKH2 Gene

Orthologs for PSKH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSKH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PSKH2 35
  • 86.42 (n)
  • 82.51 (a)
PSKH2 36
  • 83 (a)
(Pan troglodytes)
Mammalia PSKH2 35
  • 98.35 (n)
  • 97.4 (a)
PSKH2 36
  • 97 (a)
(Monodelphis domestica)
Mammalia PSKH2 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia PSKH2 36
  • 71 (a)
(Gallus gallus)
Aves -- 36
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497280 35
  • 67.26 (n)
  • 67.55 (a)
(Danio rerio)
Actinopterygii PSKH2 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea R06A10.4 37
  • 44 (a)
R06A10.4 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 36
  • 25 (a)
CMK2 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for PSKH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSKH2 Gene

Gene Tree for PSKH2 (if available)
Gene Tree for PSKH2 (if available)

Paralogs for PSKH2 Gene

genes like me logo Genes that share paralogs with PSKH2: view

Variants for PSKH2 Gene

Sequence variations from dbSNP and Humsavar for PSKH2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs56407605 - 86,064,602(+) AACTG(C/T)CTGTC reference, missense, utr-variant-5-prime
rs35315725 - 86,064,581(+) CTACC(C/T)TGACA reference, missense, utr-variant-5-prime
rs35915498 - 86,064,476(+) TAACC(A/C/T)GCCGC reference, missense
VAR_040618 A lung adenocarcinoma sample
rs16879427 - 86,064,422(+) AAACT(C/T)GATCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PSKH2 Gene

Variant ID Type Subtype PubMed ID
nsv428204 CNV Gain 18775914
nsv891146 CNV Gain 21882294
nsv891147 CNV Gain 21882294
dgv7830n71 CNV Gain 21882294
esv273774 CNV Insertion 20981092
esv268395 CNV Insertion 20981092

Variation tolerance for PSKH2 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSKH2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSKH2 Gene

Disorders for PSKH2 Gene

Relevant External Links for PSKH2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSKH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSKH2 Gene

Publications for PSKH2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. (PMID: 25495526) Zhou Z. … Liu J. (BMC Cancer 2014) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3

Products for PSKH2 Gene

Sources for PSKH2 Gene

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