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Aliases for PSKH1 Gene

Aliases for PSKH1 Gene

  • Protein Serine Kinase H1 2 3 4 5
  • EC 4 63
  • PSK-H1 3 4
  • EC 2.7.11 63

External Ids for PSKH1 Gene

Previous GeneCards Identifiers for PSKH1 Gene

  • GC16P058622
  • GC16P068304
  • GC16P067662
  • GC16P067703
  • GC16P066484
  • GC16P053800

Summaries for PSKH1 Gene

GeneCards Summary for PSKH1 Gene

PSKH1 (Protein Serine Kinase H1) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMK2D.

UniProtKB/Swiss-Prot for PSKH1 Gene

  • May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.

Gene Wiki entry for PSKH1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSKH1 Gene

Genomics for PSKH1 Gene

Regulatory Elements for PSKH1 Gene

Enhancers for PSKH1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSKH1 on UCSC Golden Path with GeneCards custom track

Promoters for PSKH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSKH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSKH1 Gene

67,893,272 bp from pter
67,929,678 bp from pter
36,407 bases
Plus strand

Genomic View for PSKH1 Gene

Genes around PSKH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSKH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSKH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSKH1 Gene

Proteins for PSKH1 Gene

  • Protein details for PSKH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase H1
    Protein Accession:
    Secondary Accessions:
    • Q9NY19

    Protein attributes for PSKH1 Gene

    424 amino acids
    Molecular mass:
    48035 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for PSKH1 Gene

Proteomics data for PSKH1 Gene at MOPED

Post-translational modifications for PSKH1 Gene

Other Protein References for PSKH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSKH1 Gene

Gene Families for PSKH1 Gene

Suggested Antigen Peptide Sequences for PSKH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with PSKH1: view

Function for PSKH1 Gene

Molecular function for PSKH1 Gene

GENATLAS Biochemistry:
protein serine/kinase of unknown function
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity depends on Ca(2+) concentration.
UniProtKB/Swiss-Prot Function:
May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.

Enzyme Numbers (IUBMB) for PSKH1 Gene

genes like me logo Genes that share phenotypes with PSKH1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PSKH1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSKH1 Gene

Localization for PSKH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSKH1 Gene

Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Cytoplasm. Note=Localized in the brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes.

Subcellular locations from

Jensen Localization Image for PSKH1 Gene COMPARTMENTS Subcellular localization image for PSKH1 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PSKH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with PSKH1: view

Pathways & Interactions for PSKH1 Gene

SuperPathways for PSKH1 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with PSKH1: view

Pathways by source for PSKH1 Gene

1 BioSystems pathway for PSKH1 Gene

Gene Ontology (GO) - Biological Process for PSKH1 Gene


No data available for SIGNOR curated interactions for PSKH1 Gene

Drugs & Compounds for PSKH1 Gene

(1) Drugs for PSKH1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for PSKH1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PSKH1: view

Transcripts for PSKH1 Gene

mRNA/cDNA for PSKH1 Gene

Unigene Clusters for PSKH1 Gene

Protein serine kinase H1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSKH1 Gene

No ASD Table

Relevant External Links for PSKH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSKH1 Gene

mRNA expression in normal human tissues for PSKH1 Gene

Protein differential expression in normal tissues from HIPED for PSKH1 Gene

This gene is overexpressed in Heart (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSKH1 Gene

SOURCE GeneReport for Unigene cluster for PSKH1 Gene Hs.513683

mRNA Expression by UniProt/SwissProt for PSKH1 Gene

Tissue specificity: Expressed in all tissues and cell lines tested with the highest level of abundance in testis.
genes like me logo Genes that share expression patterns with PSKH1: view

Protein tissue co-expression partners for PSKH1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PSKH1 Gene

Orthologs for PSKH1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSKH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PSKH1 35
  • 90.96 (n)
  • 97.88 (a)
PSKH1 36
  • 98 (a)
(Canis familiaris)
Mammalia PSKH1 35
  • 91.63 (n)
  • 96.68 (a)
PSKH1 36
  • 97 (a)
(Mus musculus)
Mammalia Pskh1 35
  • 88.36 (n)
  • 97.64 (a)
Pskh1 16
Pskh1 36
  • 98 (a)
(Pan troglodytes)
Mammalia PSKH1 35
  • 99.61 (n)
  • 100 (a)
PSKH1 36
  • 100 (a)
(Monodelphis domestica)
Mammalia PSKH1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia PSKH1 36
  • 89 (a)
(Gallus gallus)
Aves PSKH1 35
  • 81.54 (n)
  • 89.26 (a)
PSKH1 36
  • 89 (a)
(Anolis carolinensis)
Reptilia PSKH1 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pskh1 35
  • 70.43 (n)
  • 83.65 (a)
Str.19522 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14987 35
(Danio rerio)
Actinopterygii pskh1 35
  • 72.95 (n)
  • 82.1 (a)
wufc44h10 35
pskh1 36
  • 82 (a)
(Caenorhabditis elegans)
Secernentea R06A10.4 37
  • 42 (a)
R06A10.4 35
  • 54.36 (n)
  • 47.39 (a)
R06A10.4 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 36
  • 26 (a)
CMK2 36
  • 23 (a)
KSP1 38
(Hordeum vulgare)
Liliopsida Hv.2858 35
(Oryza sativa)
Liliopsida Os.5879 35
(Zea mays)
Liliopsida Zm.6306 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.584 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
Species with no ortholog for PSKH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSKH1 Gene

Gene Tree for PSKH1 (if available)
Gene Tree for PSKH1 (if available)

Paralogs for PSKH1 Gene Pseudogenes for PSKH1 Gene

genes like me logo Genes that share paralogs with PSKH1: view

Variants for PSKH1 Gene

Sequence variations from dbSNP and Humsavar for PSKH1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs35552721 - 67,909,651(+) TGACA(A/G)CCGTA reference, missense
rs3927830 -- 67,920,856(+) TCTTC(A/C)TCCAT intron-variant
rs13329995 -- 67,913,258(+) tctcc(C/T)gcctc intron-variant
rs9746560 -- 67,925,200(+) AATAt(A/T)ttttt intron-variant
rs13332194 -- 67,895,429(+) tctga(A/G)atgga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSKH1 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906813 CNV Loss 21882294
nsv1844 CNV Loss 18451855
nsv906814 CNV Loss 21882294
esv2591720 CNV Deletion 19546169
esv2670395 CNV Deletion 23128226
esv21655 CNV Loss 19812545
nsv442402 CNV CNV 18776908

Variation tolerance for PSKH1 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSKH1 Gene

Disorders for PSKH1 Gene

Relevant External Links for PSKH1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSKH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSKH1 Gene

Publications for PSKH1 Gene

  1. Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus. (PMID: 14644153) Brede G. … Prydz H. (Exp. Cell Res. 2003) 3 4 23 67
  2. A tight cluster of five unrelated human genes on chromosome 16q22.1. (PMID: 8268911) Larsen F. … Prydz H. (Hum. Mol. Genet. 1993) 2 3
  3. The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions. (PMID: 24447338) Kudoh A. … Ryo A. (Retrovirology 2014) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  5. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3

Products for PSKH1 Gene

Sources for PSKH1 Gene