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PSIP1 Gene

protein-coding   GIFtS: 59
GCID: GC09M015456

PC4 And SFRS1 Interacting Protein 1

(Previous name: PC4 and SFRS1 interacting protein 2)
(Previous symbol: PSIP2)
  See PSIP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PC4 And SFRS1 Interacting Protein 11 2     DFS 702 3
PSIP21 2 3     PC4 And SFRS1 Interacting Protein 21
LEDGF2 3 5     PAIP2
Dense Fine Speckles 70 KDa Protein2 3     p522
Lens Epithelium-Derived Growth Factor2 3     p752
Transcriptional Coactivator P75/P522 3     PC4 And SFRS1-Interacting Protein2
DFS702 3     Transcriptional Coactivator P52/P752
CLL-Associated Antigen KW-72 3     

External Ids:    HGNC: 95271   Entrez Gene: 111682   Ensembl: ENSG000001649857   OMIM: 6036205   UniProtKB: O754753   

Export aliases for PSIP1 gene to outside databases

Previous GC identifers: GC09U990091 GC00U912971 GC09M015455


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PSIP1 Gene:
PSIP1 (PC4 and SFRS1 interacting protein 1) is a protein-coding gene. Diseases associated with PSIP1 include dysembryoplastic neuroepithelial tumor. GO annotations related to this gene include activating transcription factor binding and chromatin binding. An important paralog of this gene is HDGF.

UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475
Function: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis.
Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role
in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced
apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an
adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration

Gene Wiki entry for PSIP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSIP1 gene promoter:
         MZF-1   Egr-3   SRY   Ik-3   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSIP1 promoter sequence
   Search Chromatin IP Primers for PSIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.3   Ensembl cytogenetic band:  9p22.3   HGNC cytogenetic band: 9p22.2

PSIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSIP1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M015456:  view genomic region     (about GC identifiers)

Start:
15,464,064 bp from pter      End:
15,511,017 bp from pter
Size:
46,954 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475 (See protein sequence)
Recommended Name: PC4 and SFRS1-interacting protein  
Size: 530 amino acids; 60103 Da
Subunit: Monomer. Interacts with IFRD1/PC4. Isoform 2 interacts with SFRS1. Isoform 1 interacts POGZ and CDCA7L.
Isoform 1 interacts with lentiviral integrase and acts as a chromatin tethering factor to the chromosomal DNA.
Isoform 1 interacts in particular with the human HIV-1 integrase protein (HIV-1 IN), determining its nuclear
localization, its tight association with chromatin and its protection from the proteasome. Isoform 1 interacts
also with HIV-2 IN. Isoform 2 does not interact with HIV-1 IN
Selected PDB 3D structures from and Proteopedia for PSIP1 (see all 9):
1Z9E (3D)        2B4J (3D)        2M16 (3D)        3F9K (3D)        3HPG (3D)        3HPH (3D)    
Secondary accessions: D3DRI9 O00256 O95368 Q6P391 Q86YB9 Q9NZI3 Q9UER6
Alternative splicing: 3 isoforms:  O75475-1   O75475-2   O75475-3   (Less active than isoform 2 as transcriptional coactivator, but more abundant in cells)

Explore the universe of human proteins at neXtProt for PSIP1: NX_O75475

Explore proteomics data for PSIP1 at MOPED

Post-translational modifications: 

  • Citrullinated by PADI4 (By similarity)1
  • Ubiquitination2 at Lys6, Lys75, Lys364, Lys407, Lys415, Lys422, Lys424, Lys442
  • Modification sites at PhosphoSitePlus

  • See PSIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001121689.1  NP_066967.3  NP_150091.2  

    ENSEMBL proteins: 
     ENSP00000370114   ENSP00000370109   ENSP00000370091   ENSP00000370092   ENSP00000477077  
     ENSP00000380653  
    Reactome Protein details: O75475

    PSIP1 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for PSIP1 (6 products) 

     
    antibodies-online peptides for PSIP1

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    antibodies-online antibodies for PSIP1 (31 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017859 Treacle-like_TCS
     IPR021567 LEDGF
     IPR000313 PWWP_dom

    Graphical View of Domain Structure for InterPro Entry O75475

    ProtoNet protein and cluster: O75475

    1 Blocks protein domain: IPB000313 PWWP domain

    UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475
    Domain: Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain)
    Similarity: Belongs to the HDGF family
    Similarity: Contains 1 PWWP domain


    Find genes that share domains with PSIP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSIP1_HUMAN, O75475
    Function: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis.
    Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role
    in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced
    apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an
    adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001105RNA polymerase II transcription coactivator activity IDA9822615
    GO:0003682chromatin binding IDA--
    GO:0005515protein binding IPI--
    GO:0033613activating transcription factor binding IDA9822615
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with PSIP1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PSIP1:
     Decreased cilium length after   Increased cell death HMECs cel  Lamellipodia cells 

         13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Psip1):
     adipose tissue  behavior/neurological  cellular  craniofacial  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  immune system  mortality/aging  normal 
     reproductive system  skeleton  vision/eye 

    Find genes that share phenotypes with PSIP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PSIP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PSIP1:
    hsa-mir-155-5p (MIRT020538), hsa-mir-193b-3p (MIRT016293), hsa-mir-1 (MIRT023558), hsa-mir-375 (MIRT019773)

    Block miRNA regulation of human, mouse, rat PSIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PSIP1 (see all 71):
    hsa-miR-411* hsa-miR-100* hsa-miR-607 hsa-miR-300 hsa-miR-502-3p hsa-miR-4275 hsa-miR-629* hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidPSIP1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for PSIP1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSIP1_HUMAN, O75475: Nucleus. Note=Remains chromatin-associated throughout the cell cycle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12796494
    GO:0005654nucleoplasm TAS--
    GO:0005720nuclear heterochromatin IDA12796494
    GO:0005730NOT nucleolus IDA11512661
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PSIP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSIP1 About   (see all 20)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3HIV Life Cycle
    HIV Life Cycle0.91
    APOBEC3G mediated resistance to HIV-1 infection0.00
    HIV Infection0.62
    Integration of provirus0.00
    Host Interactions of HIV factors0.60
    2-LTR circle formation0.00
    Early Phase of HIV Life Cycle0.00
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48


    Find genes that share SuperPaths with PSIP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSIP1 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    4 Cell Signaling Technology (CST) Pathways for PSIP1
        Chromatin Regulation / Acetylation
    Apoptosis and Autophagy
    Neuroscience
    Lymphocyte Signaling

    Selected Reactome Pathways for PSIP1 (see all 6)
        APOBEC3G mediated resistance to HIV-1 infection
    Integration of viral DNA into host genomic DNA
    2-LTR circle formation
    Vpr-mediated nuclear import of PICs
    Autointegration results in viral DNA circles


        Pathway & Disease-focused RT2 Profiler PCR Array including PSIP1: 
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PSIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for PSIP1 (O754751, 2, 3 ENSP000003701094) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    gag-polP045851, 2EBI-1801773,EBI-3989067 MINT-8053353 MINT-8053257 MINT-8053115 MINT-8053370 MINT-8053289 MINT-8053321 MINT-8053305 MINT-8053074 MINT-8055897 MINT-8053093 MINT-8053224 MINT-8053190 MINT-8053337 MINT-8053173 MINT-8053273 MINT-8053135 MINT-8053154 MINT-8053241 MINT-8053386 MINT-8053207 MINT-8053402
    MAPK6Q166592, 3MINT-8261769 I2D: score=2 
    SUMO1P631651, 2, ENSP000003760764EBI-1801773,EBI-80140 MINT-8384845 MINT-8384981 MINT-8384827 MINT-8384873 STRING: ENSP00000376076
    SRSF1Q079553, ENSP000002589624I2D: score=3 STRING: ENSP00000258962
    CASP3P425743, ENSP000003110324I2D: score=2 STRING: ENSP00000311032
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    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000395mRNA 5'-splice site recognition IDA9885563
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006979response to oxidative stress ISS--
    GO:0009408response to heat ISS--

    Find genes that share ontologies with PSIP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSIP1

    4 Novoseek inferred chemical compound relationships for PSIP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 4.38 3 1859372 (3)
    tyrosine 0 2 7683250 (1), 18383860 (1)
    pge2 0 2 12515286 (1)
    choline 0 1 8719339 (1)



    Find genes that share compounds with PSIP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSIP1 gene (3 alternative transcripts): 
    NM_001128217.1  NM_021144.3  NM_033222.3  

    Unigene Cluster for PSIP1:

    PC4 and SFRS1 interacting protein 1
    Hs.658434  [show with all ESTs]
    Unigene Representative Sequence: BX649155
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380738 ENST00000380733(uc003zlv.4 uc003zlw.4) ENST00000380715(uc003zly.3)
    ENST00000380716(uc003zlz.4 uc003zma.4) ENST00000481862 ENST00000495873
    ENST00000487363 ENST00000463712 ENST00000488797 ENST00000484265 ENST00000397519

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    hsa-miR-411* hsa-miR-100* hsa-miR-607 hsa-miR-300 hsa-miR-502-3p hsa-miR-4275 hsa-miR-629* hsa-miR-4274
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    Addgene plasmids for PSIP1 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSIP1
      QuantiTect SYBR Green Assays in human, mouse, rat PSIP1
      QuantiFast Probe-based Assays in human, mouse, rat PSIP1

    Additional mRNA sequence: 

    AF063020.1 AF098482.1 AF098483.1 AF432220.1 AK096405.1 BC013160.1 BC022971.1 BC033817.1 
    BC040032.1 BC044568.1 BC064135.1 BX649155.1 U94319.1 

    Selected DOTS entries (see all 25):

    DT.445763  DT.100780066  DT.100650049  DT.95197396  DT.306932  DT.437574  DT.100673406  DT.101982423 
    DT.95169258  DT.95169253  DT.95169260  DT.95250402  DT.95169257  DT.97805561  DT.100044520  DT.100740025 
    DT.100835979  DT.204435  DT.92441357  DT.95232316  DT.100042383  DT.40119388  DT.40261786  DT.452382 

    Selected AceView cDNA sequences (see all 232):

    AA285372 AK096405 BU683489 BI754276 AU119069 BQ436584 BC064135 BE348945 
    AL046720 BM557625 BC013160 AI419513 AW167367 AA228130 AI056155 AA773624 
    AA456657 AU132459 BE856265 BQ009675 BM682808 AA490641 BU684966 BQ232348 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PSIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGAAATT
    PSIP1 Expression
    About this image


    PSIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
    PSIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658434

    UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475
    Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain.
    Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult
    brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal
    brain, expressed in the germinal neuroepithelium and cortical plate regions

        Pathway & Disease-focused RT2 Profiler PCR Array including PSIP1: 
              NFKB Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PSIP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psip11 , 5 PC4 and SFRS1 interacting protein 11, 5 90.09(n)1
    91.67(a)1
      4 (39.46 cM)5
    1017391  NM_133948.41  NP_598709.11 
     834556805 
    chicken
    (Gallus gallus)
    Aves PSIP11 PC4 and SFRS1 interacting protein 1 76.33(n)
    75.19(a)
      431605  NM_001031610.2  NP_001026781.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    80(a)
    68(a)
    1 ↔ many
    1 ↔ many
    2(105347723-105348226)
    2(35032849-35076600)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985452 hypothetical protein LOC398545 77.97(n)    BC041497.1 
    zebrafish
    (Danio rerio)
    Actinopterygii psip11 PC4 and SFRS1 interacting protein 1 62.06(n)
    60.13(a)
      553760  NM_001020726.1  NP_001018562.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79466
    --
    19(a)
    1 → many
    3R(25878236-25880419)
    worm
    (Caenorhabditis elegans)
    Secernentea C06A5.36
    Protein C06A5.3, isoform b (C06A5.3) mRNA, complet...
    13(a)
    1 → many
    I(5986492-5990581) WBGene00015501


    ENSEMBL Gene Tree for PSIP1 (if available)
    TreeFam Gene Tree for PSIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSIP1 gene
    HDGF2  HDGFL12  HDGFRP32  HDGFRP22  
    6 SIMAP similar genes for PSIP1 using alignment to 5 protein entries:     PSIP1_HUMAN (see all proteins):
    HDGFRP3    HDGFRP2    HDGF    GTBP    MSH6    HDGFL1

    Find genes that share paralogs with PSIP1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PSIP1
    PGOHUM00000246143 PGOHUM00000233132 PGOHUM00000236393


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSIP1 (see all 1365)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs744735581,2
    C,F--15463613(+) TTTCAA/TTGATC 2 -- int12Minor allele frequency- T:0.03NA EA 240
    rs781179851,2
    C,F--15463639(+) TCTTAT/CGAATA 2 -- int11Minor allele frequency- C:0.24WA 118
    rs561111541,2
    C,F--15463669(+) AGTTAC/TCTGTA 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1388899671,2
    C--15463690(+) GACAC-/CAAGCA
            
    CATTT
    2 -- cds10--------
    rs1813146301,2
    C--15463753(+) CAACTA/GGTTAG 2 -- int10--------
    rs600463771,2
    C,F--15463820(+) GAATTG/TGAATA 2 -- int16Minor allele frequency- T:0.24WA CSA EA 246
    rs1489554211,2
    C--15463900(+) AAATA-/TTACC 
            
    TTTAT
    2 -- int10--------
    rs2005260421,2
    C--15463904(-) ATAAAA/GGTAAT 2 -- int10--------
    rs1437039031,2
    C--15464069(+) TTTGAC/TAGAAA 2 -- ut310--------
    rs1472134341,2
    --15464167(+) CAGATA/CATGAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PSIP1 (15464064 - 15511017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PSIP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517975CNV Loss19592680
    nsv892626CNV Loss21882294
    nsv892627CNV Gain21882294
    nsv892628CNV Gain21882294
    nsv892625CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for PSIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603620    OMIM disorders: --

    UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475
  • Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML)
    with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation
    t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4

  • 1 disease for PSIP1:    
    About MalaCards
    dysembryoplastic neuroepithelial tumor


    Find genes that share disorders with PSIP1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PSIP1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 45.3 16 9694711 (1), 19801648 (1), 17267486 (1), 18331842 (1) (see all 11)
    dermatitis atopic 34.5 1 10856157 (1)
    autoimmunity 22.9 4 15022305 (1), 18598942 (1)
    shock 22.6 7 11687539 (1), 16318853 (1), 16403949 (1), 20053771 (1) (see all 7)
    rhabdomyosarcoma 13.1 1 11567228 (1)
    leukemia 7.14 10 11737860 (1), 18598937 (1), 18598942 (1)
    autoimmune diseases 3.32 1 15501396 (1)
    glaucoma 0 1 17506493 (1)
    necrosis 0 3 11567228 (1), 9491229 (1)
    cataract 0 6 10623627 (1), 10803429 (1), 12515286 (1)


    Export disorders for PSIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSIP1 gene, integrated from 10 sources (see all 275):
    (articles sorted by number of sources associating them with PSIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. (PubMed id 9822615)1, 2, 3, 9 Ge H.... Roeder R.G. (EMBO J. 1998)
    2. A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. (PubMed id 9885563)1, 2, 3, 9 Ge H.... Wolffe A.P. (Mol. Cell 1998)
    3. Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts. (PubMed id 10623627)1, 2, 9 Singh D.P.... Shinohara T. (Biochem. Biophys. Res. Commun. 2000)
    4. Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. (PubMed id 16260736)1, 2, 9 Cherepanov P....Engelman A. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    5. Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing. (PubMed id 10721720)1, 2, 9 Singh D.P.... Shinohara T. (Gene 2000)
    6. The interaction of LEDGF/p75 with integrase is lentiviral-specific and promotes DNA binding. (PubMed id 15749713)1, 2, 9 Busschots K.... Debyser Z. (J. Biol. Chem. 2005)
    7. Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. (PubMed id 15895093)1, 2, 9 Cherepanov P....Engelman A. (Nat. Struct. Mol. Biol. 2005)
    8. Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. (PubMed id 10856157)1, 2, 9 Ochs R.L.... Tan E.M. (J. Allergy Clin. Immunol. 2000)
    9. t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. (PubMed id 15725483)1, 2, 9 Morerio C.... Panarello C. (Leuk. Res. 2005)
    10. Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase. (PubMed id 15475359)1, 2, 9 Llano M.... Poeschla E.M. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11168 HGNC: 9527 AceView: PSIP1 Ensembl:ENSG00000164985 euGenes: HUgn11168
    ECgene: PSIP1 H-InvDB: PSIP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSIP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PSIP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSIP1 gene:
    Search GeneIP for patents involving PSIP1

    Licensable Technologies for PSIP1 gene:
    Weizmann Institute:A Novel target for regulating lymphangiogenesis and lymph-node metastasis
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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