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Aliases for PSIP1 Gene

Aliases for PSIP1 Gene

  • PC4 And SFRS1 Interacting Protein 1 2 3
  • LEDGF 3 4 6
  • Lens Epithelium-Derived Growth Factor 3 4
  • Transcriptional Coactivator P75/P52 3 4
  • Dense Fine Speckles 70 KDa Protein 3 4
  • CLL-Associated Antigen KW-7 3 4
  • DFS 70 3 4
  • PSIP2 3 4
  • DFS70 3 4
  • PC4 And SFRS1 Interacting Protein 2 2
  • Transcriptional Coactivator P52/P75 3
  • PC4 And SFRS1-Interacting Protein 3
  • PAIP 3
  • P52 3
  • P75 3

External Ids for PSIP1 Gene

Previous Symbols for PSIP1 Gene

  • PSIP2

Summaries for PSIP1 Gene

GeneCards Summary for PSIP1 Gene

PSIP1 (PC4 And SFRS1 Interacting Protein 1) is a Protein Coding gene. Diseases associated with PSIP1 include hiv-1 and dysembryoplastic neuroepithelial tumor. Among its related pathways are Disease and NF-KappaB Family Pathway. GO annotations related to this gene include chromatin binding and activating transcription factor binding. An important paralog of this gene is HDGFL1.

UniProtKB/Swiss-Prot for PSIP1 Gene

  • Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.

Gene Wiki entry for PSIP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSIP1 Gene

Genomics for PSIP1 Gene

Genomic Location for PSIP1 Gene

Start:
15,464,066 bp from pter
End:
15,511,019 bp from pter
Size:
46,954 bases
Orientation:
Minus strand

Genomic View for PSIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSIP1 Gene

Regulatory Elements for PSIP1 Gene

Proteins for PSIP1 Gene

  • Protein details for PSIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75475-PSIP1_HUMAN
    Recommended name:
    PC4 and SFRS1-interacting protein
    Protein Accession:
    O75475
    Secondary Accessions:
    • D3DRI9
    • O00256
    • O95368
    • Q6P391
    • Q86YB9
    • Q9NZI3
    • Q9UER6

    Protein attributes for PSIP1 Gene

    Size:
    530 amino acids
    Molecular mass:
    60103 Da
    Quaternary structure:
    • Monomer. Interacts with IFRD1/PC4. Isoform 2 interacts with SFRS1. Isoform 1 interacts POGZ and CDCA7L. Isoform 1 interacts with lentiviral integrase and acts as a chromatin tethering factor to the chromosomal DNA. Isoform 1 interacts in particular with the human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome. Isoform 1 interacts also with HIV-2 IN. Isoform 2 does not interact with HIV-1 IN.

    Three dimensional structures from OCA and Proteopedia for PSIP1 Gene

    Alternative splice isoforms for PSIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSIP1 Gene

Proteomics data for PSIP1 Gene at MOPED

Post-translational modifications for PSIP1 Gene

  • Citrullinated by PADI4.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys6, Lys75, Lys364, Lys407, Lys415, Lys422, Lys424, and Lys442

Other Protein References for PSIP1 Gene

No data available for DME Specific Peptides for PSIP1 Gene

Domains for PSIP1 Gene

Protein Domains for PSIP1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PSIP1_HUMAN
Domain:
  • Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain):
    • O75475
  • Contains 1 PWWP domain.:
    • O75475
Family:
  • Belongs to the HDGF family.:
    • O75475
genes like me logo Genes that share domains with PSIP1: view

No data available for Gene Families for PSIP1 Gene

Function for PSIP1 Gene

Molecular function for PSIP1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.

Gene Ontology (GO) - Molecular Function for PSIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001105 RNA polymerase II transcription coactivator activity IDA 9822615
GO:0003682 chromatin binding IDA 20974633
GO:0005515 protein binding IPI 17137594
GO:0033613 activating transcription factor binding IDA 9822615
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PSIP1: view
genes like me logo Genes that share phenotypes with PSIP1: view

miRNA for PSIP1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PSIP1 Gene

Localization for PSIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSIP1 Gene

Nucleus. Note=Remains chromatin-associated throughout the cell cycle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSIP1 Gene COMPARTMENTS Subcellular localization image for PSIP1 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PSIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12796494
GO:0005654 nucleoplasm TAS --
GO:0005720 nuclear heterochromatin IDA 12796494
GO:0005730 NOT nucleolus IDA 11512661
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PSIP1: view

Pathways for PSIP1 Gene

genes like me logo Genes that share pathways with PSIP1: view

Gene Ontology (GO) - Biological Process for PSIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000395 mRNA 5-splice site recognition IDA 9885563
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006979 response to oxidative stress ISS --
GO:0009408 response to heat ISS --
genes like me logo Genes that share ontologies with PSIP1: view

Compounds for PSIP1 Gene

(4) Novoseek inferred chemical compound relationships for PSIP1 Gene

Compound -log(P) Hits PubMed IDs
calcium 4.38 3
tyrosine 0 2
pge2 0 1
choline 0 1
genes like me logo Genes that share compounds with PSIP1: view

Transcripts for PSIP1 Gene

Unigene Clusters for PSIP1 Gene

PC4 and SFRS1 interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSIP1 Gene

No ASD Table

Relevant External Links for PSIP1 Gene

GeneLoc Exon Structure for
PSIP1
ECgene alternative splicing isoforms for
PSIP1

Expression for PSIP1 Gene

mRNA expression in normal human tissues for PSIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSIP1 Gene

SOURCE GeneReport for Unigene cluster for PSIP1 Gene Hs.658434

mRNA Expression by UniProt/SwissProt for PSIP1 Gene

O75475-PSIP1_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
genes like me logo Genes that share expressions with PSIP1: view

Orthologs for PSIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSIP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSIP1 36
  • 94.78 (n)
  • 97.74 (a)
PSIP1 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSIP1 36
  • 95.53 (n)
  • 97.36 (a)
PSIP1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psip1 36
  • 90.09 (n)
  • 91.67 (a)
Psip1 16
Psip1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSIP1 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSIP1 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psip1 36
  • 90.34 (n)
  • 90.91 (a)
chicken
(Gallus gallus)
Aves PSIP1 36
  • 76.33 (n)
  • 75.19 (a)
PSIP1 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 80 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398545 36
tropical clawed frog
(Silurana tropicalis)
Amphibia psip1 36
  • 66.01 (n)
  • 63.17 (a)
Str.15838 36
zebrafish
(Danio rerio)
Actinopterygii psip1 36
  • 62.06 (n)
  • 60.13 (a)
psip1 37
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7946 37
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06A5.3 37
  • 13 (a)
OneToMany
Species with no ortholog for PSIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSIP1 Gene

ENSEMBL:
Gene Tree for PSIP1 (if available)
TreeFam:
Gene Tree for PSIP1 (if available)

Paralogs for PSIP1 Gene

Paralogs for PSIP1 Gene

Selected SIMAP similar genes for PSIP1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PSIP1 Gene

genes like me logo Genes that share paralogs with PSIP1: view

Variants for PSIP1 Gene

Sequence variations from dbSNP and Humsavar for PSIP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs13248 -- 15,464,288(-) ATTGT(A/G)TGGTT utr-variant-3-prime
rs169330 -- 15,470,686(-) GTTAA(A/G)AATGA intron-variant, utr-variant-3-prime
rs191851 -- 15,470,788(-) CCTGA(A/G)AATGG intron-variant, utr-variant-3-prime
rs193362 -- 15,470,743(-) CTTTA(A/G)AATCT intron-variant, utr-variant-3-prime
rs472894 -- 15,479,877(+) AGTGA(A/G)CAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSIP1 Gene

Variant ID Type Subtype PubMed ID
nsv517975 CNV Loss 19592680
nsv892625 CNV Gain 21882294
nsv892626 CNV Loss 21882294
nsv892627 CNV Gain 21882294
nsv892628 CNV Gain 21882294

Relevant External Links for PSIP1 Gene

HapMap Linkage Disequilibrium report
PSIP1

Disorders for PSIP1 Gene

UniProtKB/Swiss-Prot

PSIP1_HUMAN
  • Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.

(12) Novoseek inferred disease relationships for PSIP1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 45.3 11
dermatitis atopic 34.5 1
autoimmunity 22.9 2
shock 22.6 7
rhabdomyosarcoma 13.1 1
genes like me logo Genes that share disorders with PSIP1: view

Publications for PSIP1 Gene

  1. Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. (PMID: 9822615) Ge H. … Roeder R.G. (EMBO J. 1998) 2 3 4 23
  2. A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. (PMID: 9885563) Ge H. … Wolffe A.P. (Mol. Cell 1998) 2 3 4 23
  3. Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts. (PMID: 10623627) Singh D.P. … Shinohara T. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  4. Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. (PMID: 10856157) Ochs R.L. … Tan E.M. (J. Allergy Clin. Immunol. 2000) 3 4 23
  5. Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing. (PMID: 10721720) Singh D.P. … Shinohara T. (Gene 2000) 3 4 23

Products for PSIP1 Gene

  • Addgene plasmids for PSIP1

Sources for PSIP1 Gene

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