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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PSIP1 Gene

protein-coding GIFtS: 56
GCID: GC09M015456

PC4 and SFRS1 interacting protein 1

(Previous name: PC4 and SFRS1 interacting protein 2 )
(Previous symbol: PSIP2)

Explore 29 diseases affiliated with
PSIP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
PC4 And SFRS1 Interacting Protein 1¹ ²		DFS70² ³
LEDGF¹ ² ³ ⁵		CLL-Associated Antigen KW-7² ³
PSIP2¹ ² ³		DFS 70² ³
P52¹		PC4 And SFRS1 Interacting Protein 2¹
P75¹		PAIP²
Dense Fine Speckles 70 KDa Protein² ³		PC4 And SFRS1-Interacting Protein²
Lens Epithelium-Derived Growth Factor² ³		Transcriptional Coactivator P52/P75²
Transcriptional Coactivator P75/P52² ³

External Ids:	HGNC: 9527¹	Entrez Gene: 11168²	Ensembl: ENSG00000164985⁷	OMIM: 603620⁵	UniProtKB: O75475³

Export aliases for PSIP1 gene to outside databases

Previous GC identifers: GC09U990091 GC00U912971 GC09M015455

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475

Function: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved

in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens

epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform

2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate

pre-mRNA splicing. Cellular cofactor for lentiviral integration

Gene Wiki entry for PSIP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PSIP1 gene promoter:
MZF-1 Egr-3 SRY Ik-3 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSIP1 promoter sequence

Search SABiosciences Chromatin IP Primers for PSIP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSIP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.3 Ensembl cytogenetic band: 9p22.3 HGNC cytogenetic band: 9p22.2

PSIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSIP1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M015456: view genomic region (about GC identifiers)

Start:	15,464,064 bp from pter	End:	15,511,017 bp from pter
Size:	46,954 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475 (See protein sequence)

Recommended Name: PC4 and SFRS1-interacting protein

Size: 530 amino acids; 60103 Da

Subunit: Monomer. Interacts with IFRD1/PC4. Isoform 2 interacts with SFRS1. Isoform 1 interacts POGZ and CDCA7L.

Isoform 1 interacts with lentiviral integrase and acts as a chromatin tethering factor to the chromosomal DNA. Isoform

1 interacts in particular with the human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its

tight association with chromatin and its protection from the proteasome. Isoform 1 interacts also with HIV-2 IN.

Isoform 2 does not interact with HIV-1 IN

Subcellular location: Nucleus. Note=Remains chromatin-associated throughout the cell cycle

6/7 PDB 3D structures from and Proteopedia for PSIP1 (see all 7):

1Z9E (3D)

2B4J (3D)

3F9K (3D)

3HPG (3D)

3HPH (3D)

3U88 (3D)

Secondary accessions: D3DRI9 O00256 O95368 Q6P391 Q86YB9 Q9NZI3 Q9UER6

Alternative splicing: 3 isoforms: O75475-1 O75475-2 O75475-3 (Less active than isoform 2 as transcriptional coactivator, but more abundant in cells)

Explore the universe of human proteins at neXtProt for PSIP1: NX_O75475

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75475

PSIP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001121689.1 NP_066967.3 NP_150091.2

ENSEMBL proteins:

ENSP00000370109 ENSP00000370114 ENSP00000370091 ENSP00000370092 ENSP00000380653

Reactome Protein details: O75475
Human Recombinant Protein Products:

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	R&D Systems Recombinant & Natural Proteins for PSIP1 (LEDGF)
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	Novus Biologicals PSIP1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PSIP1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005720	nuclear heterochromatin	IDA	12796494
GO:0005730	NOT nucleolus	IDA	--
GO:0005829	cytosol	TAS	--

PSIP1 for ontologies About GeneDecksing

PSIP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for PSIP1 (LEDGF)
	Cell Signaling Technology (CST) Antibodies for PSIP1 (LEDGF)
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	GenScript Custom Superior Antibodies Services for PSIP1
	Novus Biologicals PSIP1 Antibodies
	Search for Antibodies for PSIP1 at Abcam
	Uscn Antibodies for PSIP1
	ThermoFisher Antibody for PSIP1

Assay Products for PSIP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PSIP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PSIP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PSIP1 for domains About GeneDecksing

3 InterPro domains/families:

IPR017859 Treacle-like_TCS

IPR021567 LEDGF

IPR000313 PWWP

Graphical View of Domain Structure for InterPro Entry O75475

ProtoNet protein and cluster: O75475

1 Blocks protein family: IPB000313 PWWP domain

UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475

Domain: Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain)

Similarity: Belongs to the HDGF family

Similarity: Contains 1 PWWP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475

Function: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved

in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens

epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform

2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate

pre-mRNA splicing. Cellular cofactor for lentiviral integration

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PSIP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSIP1
		8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate PSIP1 (see all 71):
		hsa-miR-411* hsa-miR-100* hsa-miR-607 hsa-miR-300 hsa-miR-502-3p hsa-miR-4275 hsa-miR-629* hsa-miR-4274

		SwitchGear 3'UTR luciferase reporter plasmid: PSIP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSIP1 (see all 7) OriGene shRNA RFP: PSIP1 OriGene siRNA: PSIP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSIP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PSIP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSIP1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSIP1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): PSIP1 (NM_001128217)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSIP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSIP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PSIP1
		Search LifeMap BioReagents cell lines for PSIP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSIP1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001105	RNA polymerase II transcription coactivator activity	IDA	9885563
GO:0003682	chromatin binding	IDA	--
GO:0005515	protein binding	IPI	9885563
GO:0033613	activating transcription factor binding	IDA	9822615
GO:0097100	supercoiled DNA binding	ISS	--

PSIP1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for PSIP1:

Decreased cilium length after

Increased cell death HMECs cel

Lamellipodia cells

Animal Models:
12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Psip1):

adipose tissue	behavior/neurological	cellular	craniofacial	endocrine/exocrine gland
hematopoietic system	immune system	mortality/aging	normal	reproductive system
skeleton	vision/eye

PSIP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PSIP1 (see all 54)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

4 Cell Signaling Technology (CST) Pathways for PSIP1

	Chromatin Regulation / Acetylation
	Apoptosis and Autophagy
	Neuroscience
	Lymphocyte Signaling

5/12 Reactome Pathways for PSIP1 (see all 12)

	Interactions of Vpr with host cellular proteins
	Early Phase of HIV Life Cycle
	Disease
	Host Interactions of HIV factors
	HIV Life Cycle

PSIP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PSIP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/27 Interacting proteins for PSIP1 (O75475^{2, 3} ENSP00000370109⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK6	Q16659²^,³	MINT-8261769 I2D: score=2
SUMO1	P63165², ENSP00000376076⁴	MINT-8384845 MINT-8384981 MINT-8384827 MINT-8384873 STRING: ENSP00000376076
SRSF1	Q07955³, ENSP00000258962⁴	I2D: score=3 STRING: ENSP00000258962
CASP3	P42574³, ENSP00000311032⁴	I2D: score=2 STRING: ENSP00000311032
HCFC1	P51610³, ENSP00000309555⁴	I2D: score=2 STRING: ENSP00000309555

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000395	mRNA 5'-splice site recognition	IDA	9885563
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006979	response to oxidative stress	ISS	--
GO:0009408	response to heat	ISS	--

PSIP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PSIP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PSIP1
4 Novoseek chemical compound relationships for PSIP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	4.38	3	1859372 (3)
tyrosine	0	2	7683250 (1), 18383860 (1)
pge2	0	2	12515286 (1)
choline	0	1	8719339 (1)

Search CenterWatch for drugs/clinical trials and news about PSIP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PSIP1 gene (3 alternative transcripts):

NM_001128217.1 NM_021144.3 NM_033222.3

Unigene Cluster for PSIP1:

PC4 and SFRS1 interacting protein 1

Hs.741408 [show with all ESTs]

Unigene Representative Sequence: BX649155

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380733(uc003zlv.4 uc003zlw.4) ENST00000380738 ENST00000380715(uc003zly.3)

ENST00000380716(uc003zlz.4 uc003zma.4) ENST00000481862 ENST00000495873

ENST00000487363 ENST00000463712 ENST00000488797 ENST00000484265 ENST00000397519

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PSIP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSIP1
		8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate PSIP1 (see all 71):
		hsa-miR-411* hsa-miR-100* hsa-miR-607 hsa-miR-300 hsa-miR-502-3p hsa-miR-4275 hsa-miR-629* hsa-miR-4274

		SwitchGear 3'UTR luciferase reporter plasmid: PSIP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSIP1 (see all 7) OriGene shRNA RFP: PSIP1 OriGene siRNA: PSIP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSIP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSIP1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSIP1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): PSIP1 (NM_001128217)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSIP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSIP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSIP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PSIP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSIP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSIP1

Additional cDNA sequence:

AF063020.1 AF098482.1 AF098483.1 AF432220.1 AK096405.1 BC013160.1 BC022971.1 BC033817.1

BC040032.1 BC044568.1 BC064135.1 BX649155.1 U94319.1

24/25 DOTS entries (see all 25):

DT.445763 DT.100780066 DT.100650049 DT.95197396 DT.306932 DT.100673406 DT.101982423 DT.95169258

DT.437574 DT.95169253 DT.95169260 DT.95250402 DT.95169257 DT.97805561 DT.100044520 DT.100740025

DT.100835979 DT.204435 DT.92441357 DT.95232316 DT.100042383 DT.40119388 DT.40261786 DT.452382

24/232 AceView cDNA sequences (see all 232):

BE856265 BM682808 AW167367 AA490641 BU684966 BQ434201 AU132459 AI608703

AA285372 AL046720 AK096405 AU119069 AA772105 BI754276 AI419513 BC022971

BQ009675 AI655752 AW204405 C05293 AA322886 BG113700 BP378234 BG940635

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PSIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGAAATT

About this image
See PSIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSIP1

SOURCE GeneReport for Unigene cluster: Hs.741408

UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475

Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain.

Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain,

expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed

in the germinal neuroepithelium and cortical plate regions

SABiosciences Expression via Pathway-Focused PCR Array including PSIP1:

NFKB Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSIP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PSIP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSIP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSIP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSIP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PSIP1 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PSIP1¹	PC4 and SFRS1 interacting protein 1	76.77(n) 75.95(a)		431605 NM_001031610.2 NP_001026781.2
lizard (Anolis carolinensis)	Reptilia	-- PSIP1⁶	--	75(a) 63(a)	possible ortholog 1 ↔ 1	2(105347723-105348226) 2(35034125-35075827)
African clawed frog (Xenopus laevis)	Amphibia	LOC398545²	hypothetical protein LOC398545	77.97(n)		BC041497.1
zebrafish (Danio rerio)	Actinopterygii	psip1⁶	PC4 and SFRS1 interacting protein 1	42(a)	1 ↔ 1	1(27149902-27255466)
fruit fly (Drosophila melanogaster)	Insecta	CG7946⁶	--	13(a)	1 → many	3R(25878236-25880419)
worm (Caenorhabditis elegans)	Secernentea	C06A5.3⁶	--	8(a)	possible ortholog	I(5986494-5990583)

ENSEMBL Gene Tree for PSIP1 (if available)
TreeFam Gene Tree for PSIP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PSIP1 gene

HDGF² HDGFL1² HDGFRP3² HDGFRP2²

6 SIMAP similar genes for PSIP1 using alignment to 4 protein entries: PSIP1_HUMAN (see all proteins):

HDGFRP3 HDGFRP2 HDGF GTBP MSH6 HDGFL1

PSIP1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for PSIP1
PGOHUM00000246143 PGOHUM00000233132 PGOHUM00000236393

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74473558^1,2	C,F,	--	15463613(+)	`TTTCAA/TTGATC`	2	--	int¹		2		NA EA	240
rs78117985^1,2	C,F,	--	15463639(+)	`TCTTAT/CGAATA`	2	--	int¹		1		WA	118
rs56111154^1,2	C,	--	15463669(+)	`AGTTAC/TCTGTA`	2	--	int¹		1		WA	2
rs138889967^1,2	C,	--	15463690(+)	`GACAC-/CAAGCA CATTT`	2	--	int¹		0	--	--	--	--
rs181314630^1,2		--	15463753(+)	`CAACTA/GGTTAG`	2	--	int¹		0	--	--	--	--
rs60046377^1,2	C,F,	--	15463820(+)	`GAATTG/TGAATA`	2	--	int¹		6		WA CSA EA	246
rs148955421^1,2	C,	--	15463900(+)	`AAATA-/TTACC TTTAT`	2	--	int¹		0	--	--	--	--
rs200526042^1,2	C	--	15463904(-)	`ATAAAA/GGTAAT`	2	--	int¹		0	--	--	--	--
rs143703903^1,2		--	15464069(+)	`TTTGAC/TAGAAA`	2	--	ut3¹		0	--	--	--	--
rs147213434^1,2		--	15464167(+)	`CAGATA/CATGAC`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PSIP1 (15464064 - 15511017 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PSIP1: --

SABiosciences Cancer Mutation PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for PSIP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PSIP1 for disorders About GeneDecksing

OMIM gene information: 603620 OMIM disorders: --

UniProtKB/Swiss-Prot: PSIP1_HUMAN, O75475

Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with

intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with

NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4

20/29 diseases for PSIP1 (see all 29): About MalaCards

dysembryoplastic neuroepithelial tumor dermatofibrosarcoma protuberans alopecia areata olfactory neuroblastoma

dermatofibrosarcoma atopic dermatitis chronic lymphocytic leukemia acute myeloid leukemia

alopecia glaucoma lymphocytic leukemia myeloid leukemia

dermatitis retinal degeneration cataract ependymoma

leukemia colon carcinoma neuroblastoma retinitis

10/12 Novoseek disease relationships for PSIP1 gene (see all 12) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	45.3	16	9694711 (1), 19801648 (1), 17267486 (1), 18331842 (1) (see all 11)
dermatitis atopic	34.5	1	10856157 (1)
autoimmunity	22.9	4	15022305 (1), 18598942 (1)
shock	22.6	7	11687539 (1), 16318853 (1), 16403949 (1), 20053771 (1) (see all 7)
rhabdomyosarcoma	13.1	1	11567228 (1)
leukemia	7.14	10	11737860 (1), 18598937 (1), 18598942 (1)
autoimmune diseases	3.32	1	15501396 (1)
glaucoma	0	1	17506493 (1)
necrosis	0	3	11567228 (1), 9491229 (1)
cataract	0	6	10623627 (1), 10803429 (1), 12515286 (1)

Export disorders for PSIP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PSIP1 gene, integrated from 9 sources (see all 265):
(articles sorted by number of sources associating them with PSIP1)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. (PubMed id 9822615)^{1, 2, 3, 9} Ge H.... Roeder R.G. (1998)
A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. (PubMed id 9885563)^{1, 2, 3, 9} Ge H....Wolffe A.P. (1998)
Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts. (PubMed id 10623627)^{1, 2, 9} Singh D.P.... Shinohara T. (2000)
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. (PubMed id 16260736)^{1, 2, 9} Cherepanov P....Engelman A. (2005)
Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing. (PubMed id 10721720)^{1, 2, 9} Singh D.P.... Shinohara T. (2000)
The interaction of LEDGF/p75 with integrase is lentiviral-specific and promotes DNA binding. (PubMed id 15749713)^{1, 2, 9} Busschots K.... Debyser Z. (2005)
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. (PubMed id 15895093)^{1, 2, 9} Cherepanov P....Engelman A. (2005)
Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. (PubMed id 10856157)^{1, 2, 9} Ochs R.L.... Tan E.M. (2000)
t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. (PubMed id 15725483)^{1, 2, 9} Morerio C.... Panarello C. (2005)
Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase. (PubMed id 15475359)^{1, 2, 9} Llano M.... Poeschla E.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11168	HGNC: 9527	AceView: PSIP1	Ensembl:ENSG00000164985	euGenes: HUgn11168
ECgene: PSIP1	H-InvDB: PSIP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PSIP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PSIP1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PSIP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PSIP1 gene:
Search GeneIP for patents involving PSIP1

Licensable Technologies for PSIP1 gene:

Weizmann Institute:

A Novel target for regulating lymphangiogenesis and lymph-node metastasis

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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