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Aliases for PSIP1 Gene

Aliases for PSIP1 Gene

  • PC4 And SFRS1 Interacting Protein 1 2 3 5
  • Lens Epithelium-Derived Growth Factor 3 4
  • Dense Fine Speckles 70 KDa Protein 3 4
  • CLL-Associated Antigen KW-7 3 4
  • PSIP2 3 4
  • DFS70 3 4
  • LEDGF 3 4
  • PC4 And SFRS1 Interacting Protein 2 2
  • Transcriptional Coactivator P52/P75 3
  • Transcriptional Coactivator P75/P52 4
  • PC4 And SFRS1-Interacting Protein 3
  • DFS 70 4
  • PAIP 3
  • P75 3
  • P52 3

External Ids for PSIP1 Gene

Previous HGNC Symbols for PSIP1 Gene

  • PSIP2

Previous GeneCards Identifiers for PSIP1 Gene

  • GC09U990091
  • GC00U912971
  • GC09M015455

Summaries for PSIP1 Gene

GeneCards Summary for PSIP1 Gene

PSIP1 (PC4 And SFRS1 Interacting Protein 1) is a Protein Coding gene. Diseases associated with PSIP1 include Hiv-1. Among its related pathways are Transport of the SLBP independent Mature mRNA and GPCR Pathway. GO annotations related to this gene include poly(A) RNA binding and RNA polymerase II transcription coactivator activity. An important paralog of this gene is HDGFL2.

UniProtKB/Swiss-Prot for PSIP1 Gene

  • Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.

Gene Wiki entry for PSIP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSIP1 Gene

Genomics for PSIP1 Gene

Regulatory Elements for PSIP1 Gene

Enhancers for PSIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G015421 1.1 ENCODE 21.5 +88.1 88127 3.0 HDGF FOXA2 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 PSIP1 ZDHHC21 SNAPC3 RNU6-319P
GH09G015293 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +213.8 213846 8.2 ATF1 PKNOX1 ZNF133 ZBTB40 RAD21 YY1 ZNF335 FOS ETV6 CREM TTC39B PSIP1 PIR49655
GH09G015425 0.7 ENCODE 21.6 +85.0 84971 1.4 RNF2 NR2F1 BHLHE40 JUNB DPF2 ARID1B EED IKZF1 NBN MLLT1 PSIP1 SNAPC3 RNU6-319P
GH09G015508 1.4 ENCODE dbSUPER 8.2 -0.1 -64 5.9 HDGF FOXA2 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 PSIP1 CCDC171 SNAPC3 ENSG00000278754
GH09G015275 1 ENCODE dbSUPER 9.9 +233.7 233661 3.1 HNRNPUL1 CTCF NFIB ZMYM3 ZBTB40 RAD21 GATA3 CTBP1 ADNP SMC3 TTC39B PSIP1 PIR49655
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSIP1 on UCSC Golden Path with GeneCards custom track

Promoters for PSIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000233393 419 2401 HDGF FOXA2 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for PSIP1 Gene

Chromosome:
9
Start:
15,464,066 bp from pter
End:
15,511,019 bp from pter
Size:
46,954 bases
Orientation:
Minus strand

Genomic View for PSIP1 Gene

Genes around PSIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSIP1 Gene

Proteins for PSIP1 Gene

  • Protein details for PSIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75475-PSIP1_HUMAN
    Recommended name:
    PC4 and SFRS1-interacting protein
    Protein Accession:
    O75475
    Secondary Accessions:
    • D3DRI9
    • O00256
    • O95368
    • Q6P391
    • Q86YB9
    • Q9NZI3
    • Q9UER6

    Protein attributes for PSIP1 Gene

    Size:
    530 amino acids
    Molecular mass:
    60103 Da
    Quaternary structure:
    • Monomer. Interacts with IFRD1/PC4. Isoform 2 interacts with SFRS1. Isoform 1 interacts POGZ and CDCA7L. Isoform 1 interacts with lentiviral integrase and acts as a chromatin tethering factor to the chromosomal DNA. Isoform 1 interacts in particular with the human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome. Isoform 1 interacts also with HIV-2 IN. Isoform 2 does not interact with HIV-1 IN.

    Three dimensional structures from OCA and Proteopedia for PSIP1 Gene

    Alternative splice isoforms for PSIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSIP1 Gene

Post-translational modifications for PSIP1 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at isoforms=2, 36, Lys75, Lys364, Lys407, Lys415, Lys422, and isoforms=424
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSIP1 Gene

Domains & Families for PSIP1 Gene

Protein Domains for PSIP1 Gene

Suggested Antigen Peptide Sequences for PSIP1 Gene

Graphical View of Domain Structure for InterPro Entry

O75475

UniProtKB/Swiss-Prot:

PSIP1_HUMAN :
  • Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).
  • Belongs to the HDGF family.
Domain:
  • Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).
Family:
  • Belongs to the HDGF family.
genes like me logo Genes that share domains with PSIP1: view

Function for PSIP1 Gene

Molecular function for PSIP1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.

Gene Ontology (GO) - Molecular Function for PSIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 21156026
GO:0097100 supercoiled DNA binding ISS --
genes like me logo Genes that share ontologies with PSIP1: view
genes like me logo Genes that share phenotypes with PSIP1: view

Animal Model Products

CRISPR Products

miRNA for PSIP1 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSIP1 Gene

Localization for PSIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSIP1 Gene

Nucleus. Note=Remains chromatin-associated throughout the cell cycle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSIP1 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PSIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0035327 transcriptionally active chromatin ISS --
genes like me logo Genes that share ontologies with PSIP1: view

Pathways & Interactions for PSIP1 Gene

genes like me logo Genes that share pathways with PSIP1: view

SIGNOR curated interactions for PSIP1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PSIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000395 mRNA 5-splice site recognition IDA 9885563
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006979 response to oxidative stress ISS --
GO:0009408 response to heat ISS --
genes like me logo Genes that share ontologies with PSIP1: view

Drugs & Compounds for PSIP1 Gene

(3) Drugs for PSIP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PSIP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSIP1: view

Transcripts for PSIP1 Gene

Unigene Clusters for PSIP1 Gene

PC4 and SFRS1 interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSIP1 Gene

No ASD Table

Relevant External Links for PSIP1 Gene

GeneLoc Exon Structure for
PSIP1
ECgene alternative splicing isoforms for
PSIP1

Expression for PSIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSIP1 Gene

Protein differential expression in normal tissues from HIPED for PSIP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3), Retina (8.3), Blymphocyte (8.1), and Fetal Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PSIP1 Gene



Protein tissue co-expression partners for PSIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSIP1 Gene:

PSIP1

SOURCE GeneReport for Unigene cluster for PSIP1 Gene:

Hs.658434

mRNA Expression by UniProt/SwissProt for PSIP1 Gene:

O75475-PSIP1_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.

Evidence on tissue expression from TISSUES for PSIP1 Gene

  • Eye(4.5)
  • Blood(4.4)
  • Liver(4.3)
  • Nervous system(3.9)
  • Kidney(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PSIP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSIP1 Gene

Orthologs for PSIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSIP1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSIP1 34 35
  • 95.53 (n)
cow
(Bos Taurus)
Mammalia PSIP1 34 35
  • 94.78 (n)
rat
(Rattus norvegicus)
Mammalia Psip1 34
  • 90.34 (n)
mouse
(Mus musculus)
Mammalia Psip1 34 16 35
  • 90.09 (n)
oppossum
(Monodelphis domestica)
Mammalia PSIP1 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSIP1 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSIP1 34 35
  • 76.33 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 80 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia psip1 34
  • 66.01 (n)
Str.15838 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398545 34
zebrafish
(Danio rerio)
Actinopterygii psip1 34 35
  • 62.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7946 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06A5.3 35
  • 13 (a)
OneToMany
Species where no ortholog for PSIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSIP1 Gene

ENSEMBL:
Gene Tree for PSIP1 (if available)
TreeFam:
Gene Tree for PSIP1 (if available)

Paralogs for PSIP1 Gene

Paralogs for PSIP1 Gene

(6) SIMAP similar genes for PSIP1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PSIP1 Gene

genes like me logo Genes that share paralogs with PSIP1: view

Variants for PSIP1 Gene

Sequence variations from dbSNP and Humsavar for PSIP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000025824 -- 15,504,305(+) ACAGT(-/TTAGTTA)TTAGT intron-variant
rs1000043654 -- 15,483,945(+) CACCA(A/C/T)GGTGA intron-variant
rs1000094206 -- 15,512,533(+) GAGAC(C/G)AAAGC upstream-variant-2KB
rs1000103864 -- 15,506,893(+) CCACT(A/G)TTGTT intron-variant
rs1000292717 -- 15,486,581(+) CCCTA(C/T)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSIP1 Gene

Variant ID Type Subtype PubMed ID
esv3619780 CNV loss 21293372
nsv517975 CNV loss 19592680

Variation tolerance for PSIP1 Gene

Residual Variation Intolerance Score: 9.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSIP1 Gene

Disorders for PSIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSIP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search PSIP1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PSIP1_HUMAN
  • Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4. {ECO:0000269 PubMed:15725483}.

Relevant External Links for PSIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSIP1
genes like me logo Genes that share disorders with PSIP1: view

No data available for Genatlas for PSIP1 Gene

Publications for PSIP1 Gene

  1. Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. (PMID: 9822615) Ge H. … Roeder R.G. (EMBO J. 1998) 2 3 4 22 64
  2. A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. (PMID: 9885563) Ge H. … Wolffe A.P. (Mol. Cell 1998) 2 3 4 22 64
  3. Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. (PMID: 16260736) Cherepanov P. … Engelman A. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 64
  4. t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. (PMID: 15725483) Morerio C. … Panarello C. (Leuk. Res. 2005) 3 4 22 64
  5. The interaction of LEDGF/p75 with integrase is lentiviral-specific and promotes DNA binding. (PMID: 15749713) Busschots K. … Debyser Z. (J. Biol. Chem. 2005) 3 4 22 64

Products for PSIP1 Gene

Sources for PSIP1 Gene

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