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Aliases for PSG9 Gene

Aliases for PSG9 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 9 2 3 5
  • Pregnancy-Specific Beta-1 Glycoprotein B 3 4
  • PS-Beta-G-11 3 4
  • PS-Beta-G-9 3 4
  • PS-Beta-B 3 4
  • PSBG-11 3 4
  • PSBG-9 3 4
  • PSG11 3 4
  • PS34 3 4
  • Pregnancy Specific Beta-1-Glycoprotein 11 3
  • Pregnancy-Specific Beta-1-Glycoprotein 11 4
  • Pregnancy-Specific Glycoprotein 11 4
  • Pregnancy-Specific Glycoprotein 9 4
  • Pregnancy-Specific Glycoprotein 7 4
  • PSGII 3
  • PSG7 4

External Ids for PSG9 Gene

Previous HGNC Symbols for PSG9 Gene

  • PSG11

Previous GeneCards Identifiers for PSG9 Gene

  • GC19M044404
  • GC19M044089
  • GC19M048433
  • GC19M048449
  • GC19M043717
  • GC19M043718
  • GC19M040187
  • GC19M043757

Summaries for PSG9 Gene

Entrez Gene Summary for PSG9 Gene

  • The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Several studies suggest that reduced serum concentrations of PSGs are associated with fetal growth restrictions, while up-regulation of this gene has been observed in colorectal cancers. Several pseudogenes of this gene are found on chromosome 19. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]

GeneCards Summary for PSG9 Gene

PSG9 (Pregnancy Specific Beta-1-Glycoprotein 9) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

Gene Wiki entry for PSG9 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG9 Gene

Genomics for PSG9 Gene

Regulatory Elements for PSG9 Gene

Enhancers for PSG9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSG9 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG9 Gene

43,211,791 bp from pter
43,269,563 bp from pter
57,773 bases
Minus strand

Genomic View for PSG9 Gene

Genes around PSG9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG9 Gene

Proteins for PSG9 Gene

  • Protein details for PSG9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 9
    Protein Accession:
    Secondary Accessions:
    • B2R869
    • Q15227
    • Q15236
    • Q15237
    • Q8WW78
    • Q9UQ73

    Protein attributes for PSG9 Gene

    426 amino acids
    Molecular mass:
    48272 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PSG9 Gene


neXtProt entry for PSG9 Gene

Proteomics data for PSG9 Gene at MOPED

Post-translational modifications for PSG9 Gene

  • Glycosylation at Asn 104, Asn 111, Asn 199, Asn 268, Asn 303, and Asn 387
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PSG9

No data available for DME Specific Peptides for PSG9 Gene

Domains & Families for PSG9 Gene

Protein Domains for PSG9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG9: view

Function for PSG9 Gene

Molecular function for PSG9 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 9,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Phenotypes for PSG9 Gene

GenomeRNAi human phenotypes for PSG9:
genes like me logo Genes that share phenotypes with PSG9: view

Animal Model Products

CRISPR Products

miRNA for PSG9 Gene

miRTarBase miRNAs that target PSG9

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG9 Gene

Localization for PSG9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG9 Gene


Subcellular locations from

Jensen Localization Image for PSG9 Gene COMPARTMENTS Subcellular localization image for PSG9 gene
Compartment Confidence
extracellular 4
mitochondrion 2
plasma membrane 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for PSG9 Gene

Pathways & Interactions for PSG9 Gene

SuperPathways for PSG9 Gene

No Data Available

Interacting Proteins for PSG9 Gene

Gene Ontology (GO) - Biological Process for PSG9 Gene


No data available for Pathways by source and SIGNOR curated interactions for PSG9 Gene

Drugs & Compounds for PSG9 Gene

No Compound Related Data Available

Transcripts for PSG9 Gene

mRNA/cDNA for PSG9 Gene

(5) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSG9 Gene

Pregnancy specific beta-1-glycoprotein 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSG9 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - - -
SP4: - - - -

Relevant External Links for PSG9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSG9 Gene

mRNA expression in normal human tissues for PSG9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG9 Gene

This gene is overexpressed in Testis (x7.4).

Protein differential expression in normal tissues from HIPED for PSG9 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG9 Gene

SOURCE GeneReport for Unigene cluster for PSG9 Gene Hs.502092

genes like me logo Genes that share expression patterns with PSG9: view

Protein tissue co-expression partners for PSG9 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PSG9 Gene

Orthologs for PSG9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSG9 35
  • 96.86 (n)
  • 93.96 (a)
PSG9 36
  • 94 (a)
(Bos Taurus)
Mammalia -- 36
  • 25 (a)
  • 34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
(Mus musculus)
Mammalia Psg23 36
  • 22 (a)
Species with no ortholog for PSG9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG9 Gene

Gene Tree for PSG9 (if available)
Gene Tree for PSG9 (if available)

Paralogs for PSG9 Gene

genes like me logo Genes that share paralogs with PSG9: view

Variants for PSG9 Gene

Sequence variations from dbSNP and Humsavar for PSG9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1135905 - 43,258,871(-) AGTCA(C/T)CCTAA intron-variant, reference, missense
rs2074923 - 43,258,324(+) CTGAT(A/C/T)GCTGA reference, missense
rs2072285 - 43,258,255(+) AGTTA(C/T)GAACA reference, missense
VAR_058296 -
rs8101191 - 43,269,380(+) CAGGA(A/C/G)CCCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PSG9 Gene

Variant ID Type Subtype PubMed ID
dgv1087e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
dgv1089e1 CNV Complex 17122850
dgv3891n71 CNV Gain 21882294
dgv411n27 CNV Loss 19166990
esv2663048 CNV Deletion 23128226
dgv3898n71 CNV Loss 21882294
esv22277 CNV Gain+Loss 19812545
nsv470145 CNV Loss 18288195
dgv565e201 CNV Deletion 23290073
dgv3921n71 CNV Loss 21882294
nsv912001 CNV Gain 21882294
dgv1092e1 CNV Complex 17122850
dgv3925n71 CNV Gain 21882294
nsv437832 CNV Loss 16327808
dgv1094e1 CNV Complex 17122850
dgv3930n71 CNV Gain 21882294
esv2718603 CNV Deletion 23290073
nsv912046 CNV Gain+Loss 21882294
esv2751795 CNV Loss 17911159
dgv3933n71 CNV Gain 21882294
dgv3934n71 CNV Loss 21882294
esv2671292 CNV Deletion 23128226
dgv3941n71 CNV Loss 21882294
dgv1096e1 CNV Complex 17122850
nsv912096 CNV Gain+Loss 21882294
nsv437833 CNV Loss 16327808
nsv912105 CNV Gain 21882294
essv22369 CNV CNV 17122850
dgv1097e1 CNV Complex 17122850
dgv1098e1 CNV Complex 17122850
nsv458705 CNV Loss 19166990
nsv817848 CNV Loss 17921354
dgv1100e1 CNV Complex 17122850
esv34676 CNV Loss 17911159
nsv2499 CNV Loss 18451855
dgv590n67 CNV Loss 20364138
esv33039 CNV Gain 17666407
nsv435702 CNV Deletion 17901297
dgv645e199 CNV Deletion 23128226
esv6630 CNV Loss 19470904
nsv820547 CNV Deletion 20802225
esv1002165 CNV Gain 20482838
dgv1104e1 CNV Complex 17122850
dgv1105e1 CNV Complex 17122850
dgv566e201 CNV Deletion 23290073
nsv469787 CNV Loss 16826518
nsv912106 CNV Gain 21882294
nsv436856 CNV Insertion 17901297
essv21588 CNV CNV 17122850
esv2675877 CNV Deletion 23128226
essv23156 CNV CNV 17122850
nsv471414 CNV Duplication 19718026
nsv482045 CNV Gain 20164927
esv2718609 CNV Deletion 23290073
essv24618 CNV CNV 17122850
nsv511618 CNV Loss 21212237

Variation tolerance for PSG9 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.01; 84.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSG9 Gene

Disorders for PSG9 Gene

Relevant External Links for PSG9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSG9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG9 Gene

Publications for PSG9 Gene

  1. Characterization of the PSG11 gene. (PMID: 7806221) McLenachan P.A. … Mansfield B.C. (Genomics 1994) 2 3 4 23 67
  2. Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis. (PMID: 15982419) Salahshor S. … Woodgett J.R. (BMC Cancer 2005) 3 23
  3. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PMID: 7794280) Teglund S. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1995) 3 23
  4. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PMID: 1690992) Thompson J. … Hardman N. (Biochem. Biophys. Res. Commun. 1990) 3 23
  5. Identification of a new carcinoembryonic antigen (CEA) family member in human fetal liver -- cloning and sequence determination of pregnancy-specific glycoprotein 7. (PMID: 2328001) Khan W.N. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1990) 3 23

Products for PSG9 Gene

Sources for PSG9 Gene