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Aliases for PSG7 Gene

Aliases for PSG7 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 7 (Gene/Pseudogene) 2 3 5
  • Pregnancy-Specific Glycoprotein 7 3 4
  • PS-Beta-G-7 3 4
  • PSBG-7 3 4
  • Pregnancy Specific Beta-1-Glycoprotein 7 2
  • PSGGA 3
  • PSG1 3

External Ids for PSG7 Gene

Previous GeneCards Identifiers for PSG7 Gene

  • GC19U990084
  • GC19M043820
  • GC19M048104
  • GC19M048120
  • GC19M047924
  • GC19M043429
  • GC19M039857

Summaries for PSG7 Gene

Entrez Gene Summary for PSG7 Gene

  • This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for PSG7 Gene

PSG7 (Pregnancy Specific Beta-1-Glycoprotein 7 (Gene/Pseudogene)) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG7 Gene

Genomics for PSG7 Gene

Regulatory Elements for PSG7 Gene

Enhancers for PSG7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSG7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG7 Gene

Chromosome:
19
Start:
42,906,822 bp from pter
End:
43,082,671 bp from pter
Size:
175,850 bases
Orientation:
Minus strand

Genomic View for PSG7 Gene

Genes around PSG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG7 Gene

Proteins for PSG7 Gene

  • Protein details for PSG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13046-PSG7_HUMAN
    Recommended name:
    Putative pregnancy-specific beta-1-glycoprotein 7
    Protein Accession:
    Q13046
    Secondary Accessions:
    • Q15232

    Protein attributes for PSG7 Gene

    Size:
    419 amino acids
    Molecular mass:
    47001 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSG7 Gene

Proteomics data for PSG7 Gene at MOPED

Post-translational modifications for PSG7 Gene

  • Glycosylation at Asn 61, Asn 104, Asn 111, Asn 199, Asn 209, Asn 268, and Asn 303
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG7 Gene

No data available for DME Specific Peptides for PSG7 Gene

Domains & Families for PSG7 Gene

Protein Domains for PSG7 Gene

Suggested Antigen Peptide Sequences for PSG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13046

UniProtKB/Swiss-Prot:

PSG7_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG7: view

Function for PSG7 Gene

Molecular function for PSG7 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 7,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Phenotypes for PSG7 Gene

GenomeRNAi human phenotypes for PSG7:
genes like me logo Genes that share phenotypes with PSG7: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PSG7 Gene

Localization for PSG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG7 Gene

Secreted.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PSG7 Gene

Pathways & Interactions for PSG7 Gene

SuperPathways for PSG7 Gene

No Data Available

Interacting Proteins for PSG7 Gene

Gene Ontology (GO) - Biological Process for PSG7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PSG7 Gene

Drugs & Compounds for PSG7 Gene

No Compound Related Data Available

Transcripts for PSG7 Gene

Unigene Clusters for PSG7 Gene

Pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSG7 Gene

No ASD Table

Relevant External Links for PSG7 Gene

GeneLoc Exon Structure for
PSG7
ECgene alternative splicing isoforms for
PSG7

Expression for PSG7 Gene

mRNA expression in normal human tissues for PSG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG7 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.7) and Skin - Not Sun Exposed (Suprapubic) (x7.3).

SOURCE GeneReport for Unigene cluster for PSG7 Gene Hs.709203

genes like me logo Genes that share expression patterns with PSG7: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PSG7 Gene

Orthologs for PSG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PSG7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSG1 35
  • 94.59 (n)
  • 90.21 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 27 (a)
ManyToMany
CEACAM1 36
  • 34 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 27 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam12 36
  • 26 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730899 35
  • 45.05 (n)
  • 38.79 (a)
Species with no ortholog for PSG7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG7 Gene

ENSEMBL:
Gene Tree for PSG7 (if available)
TreeFam:
Gene Tree for PSG7 (if available)

Paralogs for PSG7 Gene

(22) SIMAP similar genes for PSG7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PSG7: view

Variants for PSG7 Gene

Sequence variations from dbSNP and Humsavar for PSG7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_056075 -
rs7257908 -- 42,928,371(+) ctttg(C/T)gtagt intron-variant
rs7257922 -- 42,928,445(+) atatc(A/G)tcttt intron-variant
rs7257970 -- 42,924,925(+) atggg(C/T)atctc intron-variant
rs7258205 -- 42,925,040(+) atgga(C/T)tatgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSG7 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV Deletion 17116639
dgv15e196 CNV Deletion 17116639
dgv1086e1 CNV Complex 17122850
dgv1087e1 CNV Complex 17122850
dgv1088e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
nsv428364 CNV Gain+Loss 18775914
dgv3890n71 CNV Gain 21882294
dgv1089e1 CNV Complex 17122850
dgv141e55 CNV Loss 17911159
dgv3891n71 CNV Gain 21882294
esv33217 CNV Loss 17666407
dgv1090e1 CNV Complex 17122850
nsv828554 CNV Gain 20364138
dgv3893n71 CNV Loss 21882294
dgv3894n71 CNV Gain 21882294
dgv3895n71 CNV Loss 21882294
nsv2497 CNV Loss 18451855
nsv470143 CNV Gain 18288195
dgv409n27 CNV Loss 19166990
dgv410n27 CNV Gain 19166990
dgv411n27 CNV Loss 19166990
dgv142e55 CNV Loss 17911159
esv2663048 CNV Deletion 23128226
dgv3896n71 CNV Loss 21882294
dgv3897n71 CNV Gain+Loss 21882294
nsv911839 CNV Gain+Loss 21882294
dgv3898n71 CNV Loss 21882294
dgv589n67 CNV Loss 20364138
nsv442766 CNV CNV 18776908
dgv1091e1 CNV Complex 17122850
dgv3900n71 CNV Gain 21882294
esv22277 CNV Gain+Loss 19812545
esv2421673 OTHER Complex 20811451
dgv3901n71 CNV Loss 21882294
esv2668472 CNV Deletion 23128226
esv2718595 CNV Deletion 23290073
nsv817842 CNV Gain+Loss 17921354
nsv817843 CNV Gain 17921354
nsv470145 CNV Loss 18288195
dgv3902n71 CNV Loss 21882294
dgv3903n71 CNV Loss 21882294
essv17365 CNV CNV 17122850
dgv3904n71 CNV Gain+Loss 21882294
dgv3905n71 CNV Gain 21882294
dgv3906n71 CNV Loss 21882294
dgv3907n71 CNV Gain 21882294
dgv3908n71 CNV Loss 21882294
dgv565e201 CNV Deletion 23290073
nsv911910 CNV Gain 21882294
dgv3909n71 CNV Gain+Loss 21882294
dgv3910n71 CNV Loss 21882294
dgv3911n71 CNV Gain+Loss 21882294
dgv3912n71 CNV Loss 21882294
dgv3913n71 CNV Loss 21882294
dgv412n27 CNV Gain 19166990
dgv413n27 CNV Loss 19166990
dgv414n27 CNV Gain 19166990
dgv415n27 CNV Gain 19166990
dgv416n27 CNV Loss 19166990
dgv3914n71 CNV Loss 21882294
dgv3915n71 CNV Loss 21882294
dgv3916n71 CNV Loss 21882294
esv2718600 CNV Deletion 23290073
esv2668787 CNV Deletion 23128226
nsv911980 CNV Loss 21882294
nsv458650 CNV Loss 19166990
nsv911981 CNV Loss 21882294
dgv417n27 CNV Loss 19166990
esv2751794 CNV Gain 17911159
esv2718602 CNV Deletion 23290073
nsv471411 CNV Duplication 19718026
nsv482041 CNV Gain 20164927
nsv458653 CNV Loss 19166990

Relevant External Links for PSG7 Gene

HapMap Linkage Disequilibrium report
PSG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PSG7 Gene

Disorders for PSG7 Gene

Relevant External Links for PSG7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSG7

No disorders were found for PSG7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG7 Gene

Publications for PSG7 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 67
  2. Expression and transcriptional regulation of individual pregnancy-specific glycoprotein genes in differentiating trophoblast cells. (PMID: 20116096) Camolotto S. … Panzetta-Dutari G.M. (Placenta 2010) 3
  3. The FOXF2 pathway in the human prostate stroma. (PMID: 19562724) van der Heul-Nieuwenhuijsen L. … Jenster G. (Prostate 2009) 3
  4. Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence. (PMID: 18792801) Endoh M. … Ayusawa D. (Biogerontology 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for PSG7 Gene

Sources for PSG7 Gene

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