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Aliases for PSG7 Gene

Aliases for PSG7 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 7 (Gene/Pseudogene) 2 3 5
  • Pregnancy-Specific Glycoprotein 7 3 4
  • PS-Beta-G-7 3 4
  • PSBG-7 3 4
  • Putative Pregnancy-Specific Beta-1-Glycoprotein 7 3
  • Pregnancy Specific Beta-1-Glycoprotein 7 2
  • PSGGA 3
  • PSG1 3

External Ids for PSG7 Gene

Previous GeneCards Identifiers for PSG7 Gene

  • GC19U990084
  • GC19M043820
  • GC19M048104
  • GC19M048120
  • GC19M047924
  • GC19M043429
  • GC19M039857

Summaries for PSG7 Gene

Entrez Gene Summary for PSG7 Gene

  • This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for PSG7 Gene

PSG7 (Pregnancy Specific Beta-1-Glycoprotein 7 (Gene/Pseudogene)) is a Protein Coding gene. An important paralog of this gene is PSG4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG7 Gene

Genomics for PSG7 Gene

Regulatory Elements for PSG7 Gene

Enhancers for PSG7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PSG7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG7 Gene

Chromosome:
19
Start:
42,906,822 bp from pter
End:
42,937,178 bp from pter
Size:
30,357 bases
Orientation:
Minus strand

Genomic View for PSG7 Gene

Genes around PSG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG7 Gene

Proteins for PSG7 Gene

  • Protein details for PSG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13046-PSG7_HUMAN
    Recommended name:
    Putative pregnancy-specific beta-1-glycoprotein 7
    Protein Accession:
    Q13046
    Secondary Accessions:
    • Q15232

    Protein attributes for PSG7 Gene

    Size:
    419 amino acids
    Molecular mass:
    47001 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSG7 Gene

Post-translational modifications for PSG7 Gene

  • Glycosylation at Asn 61, Asn 104, Asn 111, Asn 199, Asn 209, Asn 268, and Asn 303
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG7 Gene

No data available for DME Specific Peptides for PSG7 Gene

Domains & Families for PSG7 Gene

Gene Families for PSG7 Gene

Protein Domains for PSG7 Gene

Suggested Antigen Peptide Sequences for PSG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13046

UniProtKB/Swiss-Prot:

PSG7_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG7: view

Function for PSG7 Gene

Molecular function for PSG7 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 7,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Phenotypes for PSG7 Gene

GenomeRNAi human phenotypes for PSG7:
genes like me logo Genes that share phenotypes with PSG7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PSG7 Gene

Localization for PSG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG7 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for PSG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSG7: view

No data available for Subcellular locations from COMPARTMENTS for PSG7 Gene

Pathways & Interactions for PSG7 Gene

SuperPathways for PSG7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PSG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS 1690992
genes like me logo Genes that share ontologies with PSG7: view

No data available for Pathways by source and SIGNOR curated interactions for PSG7 Gene

Drugs & Compounds for PSG7 Gene

No Compound Related Data Available

Transcripts for PSG7 Gene

Unigene Clusters for PSG7 Gene

Pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSG7 Gene

No ASD Table

Relevant External Links for PSG7 Gene

GeneLoc Exon Structure for
PSG7
ECgene alternative splicing isoforms for
PSG7

Expression for PSG7 Gene

mRNA expression in normal human tissues for PSG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG7 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.7) and Skin - Not Sun Exposed (Suprapubic) (x7.3).

NURSA nuclear receptor signaling pathways regulating expression of PSG7 Gene:

PSG7

SOURCE GeneReport for Unigene cluster for PSG7 Gene:

Hs.709203
genes like me logo Genes that share expression patterns with PSG7: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PSG7 Gene

Orthologs for PSG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PSG7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSG1 34
  • 94.59 (n)
  • 90.21 (a)
cow
(Bos Taurus)
Mammalia -- 35
  • 27 (a)
ManyToMany
CEACAM1 35
  • 34 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 27 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam12 35
  • 26 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730899 34
  • 45.05 (n)
  • 38.79 (a)
Species where no ortholog for PSG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG7 Gene

ENSEMBL:
Gene Tree for PSG7 (if available)
TreeFam:
Gene Tree for PSG7 (if available)

Paralogs for PSG7 Gene

(22) SIMAP similar genes for PSG7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PSG7: view

Variants for PSG7 Gene

Sequence variations from dbSNP and Humsavar for PSG7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_056075 -
rs3859465 -- 42,931,205(+) TTCAT(A/T)AGTGG intron-variant
rs11083666 -- 42,928,608(+) TCTGA(A/C)GAATG intron-variant
rs28409818 -- 42,927,203(+) ACTGA(G/T)CAGCC intron-variant
rs4426457 -- 42,932,137(+) tcctg(C/T)ctcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSG7 Gene

Variant ID Type Subtype PubMed ID
dgv140e55 CNV gain 17911159
dgv141e55 CNV loss 17911159
dgv142e55 CNV loss 17911159
dgv143n111 CNV deletion 26073780
dgv144n111 CNV deletion 26073780
dgv15e196 CNV deletion 17116639
dgv223e215 CNV deletion 23714750
dgv3556n100 CNV gain 25217958
dgv3557n100 CNV gain 25217958
dgv3558n100 CNV loss 25217958
dgv3563n100 CNV gain 25217958
dgv3565n100 CNV gain+loss 25217958
dgv3566n100 CNV gain 25217958
dgv3567n100 CNV gain+loss 25217958
dgv3568n100 CNV loss 25217958
dgv3569n100 CNV gain 25217958
dgv3570n100 CNV gain+loss 25217958
dgv3571n100 CNV loss 25217958
dgv3572n100 CNV gain+loss 25217958
dgv3573n100 CNV loss 25217958
dgv3574n100 CNV gain 25217958
dgv3575n100 CNV loss 25217958
dgv3576n100 CNV loss 25217958
dgv3577n100 CNV gain 25217958
dgv3578n100 CNV gain 25217958
dgv409n27 CNV loss 19166990
dgv410n27 CNV gain 19166990
dgv411n27 CNV loss 19166990
dgv412n27 CNV gain 19166990
dgv413n27 CNV loss 19166990
dgv414n27 CNV gain 19166990
dgv415n27 CNV gain 19166990
dgv416n27 CNV loss 19166990
dgv417n27 CNV loss 19166990
dgv523e201 CNV deletion 23290073
dgv524e201 CNV deletion 23290073
dgv589n67 CNV loss 20364138
dgv6464n54 CNV loss 21841781
dgv6465n54 CNV loss 21841781
dgv6466n54 CNV gain 21841781
dgv6467n54 CNV loss 21841781
dgv6468n54 CNV loss 21841781
dgv6469n54 CNV gain 21841781
dgv6470n54 CNV gain 21841781
dgv6471n54 CNV loss 21841781
dgv6472n54 CNV loss 21841781
dgv6474n54 CNV loss 21841781
dgv6475n54 CNV loss 21841781
dgv6476n54 CNV gain 21841781
dgv6477n54 CNV loss 21841781
dgv6478n54 CNV gain+loss 21841781
dgv6479n54 CNV gain 21841781
dgv6480n54 CNV gain+loss 21841781
dgv6481n54 CNV loss 21841781
dgv6482n54 CNV loss 21841781
dgv6483n54 CNV loss 21841781
dgv6484n54 CNV gain 21841781
dgv6485n54 CNV loss 21841781
dgv73e203 CNV gain+loss 21179565
esv22277 CNV gain+loss 19812545
esv2421673 OTHER complex 20811451
esv2422471 CNV deletion 17116639
esv2663048 CNV deletion 23128226
esv2668472 CNV deletion 23128226
esv2668787 CNV deletion 23128226
esv2718595 CNV deletion 23290073
esv2718600 CNV deletion 23290073
esv2718602 CNV deletion 23290073
esv2751794 CNV gain 17911159
esv2758763 CNV gain+loss 17122850
esv33217 CNV loss 17666407
esv3556427 CNV deletion 23714750
esv3556428 CNV deletion 23714750
esv3584738 CNV loss 24956385
esv3644409 CNV loss 21293372
esv3644410 CNV loss 21293372
esv3644411 CNV loss 21293372
esv3644423 CNV loss 21293372
esv3644424 CNV loss 21293372
esv3644425 CNV loss 21293372
esv3644426 CNV gain 21293372
esv3644427 CNV loss 21293372
esv3893210 CNV loss 25118596
esv3893211 CNV gain+loss 25118596
esv3893214 CNV gain+loss 25118596
esv3893216 CNV gain+loss 25118596
nsv1055587 CNV loss 25217958
nsv1056270 CNV loss 25217958
nsv1057657 CNV gain 25217958
nsv1060654 CNV gain 25217958
nsv1066044 CNV gain 25217958
nsv1066286 CNV gain+loss 25217958
nsv1142088 CNV deletion 24896259
nsv1160630 OTHER complex 26073780
nsv1160634 CNV duplication 26073780
nsv1160636 CNV duplication 26073780
nsv2497 CNV deletion 18451855
nsv428364 CNV gain+loss 18775914
nsv442766 CNV gain+loss 18776908
nsv458650 CNV loss 19166990
nsv458653 CNV loss 19166990
nsv470143 CNV gain 18288195
nsv470145 CNV loss 18288195
nsv471411 CNV gain 19718026
nsv482041 CNV gain 20164927
nsv516973 CNV gain+loss 19592680
nsv579653 CNV gain 21841781
nsv579687 CNV gain+loss 21841781
nsv579702 CNV loss 21841781
nsv579704 CNV gain 21841781
nsv579712 CNV gain+loss 21841781
nsv579732 CNV loss 21841781
nsv579735 CNV gain 21841781
nsv579736 CNV gain 21841781
nsv579738 CNV loss 21841781
nsv579740 CNV loss 21841781
nsv579743 CNV gain+loss 21841781
nsv579745 CNV loss 21841781
nsv817842 CNV gain+loss 17921354
nsv817843 CNV gain 17921354
nsv828554 CNV gain 20364138
nsv953586 CNV deletion 24416366
nsv963056 CNV duplication 23825009
nsv9730 CNV gain+loss 18304495

Relevant External Links for PSG7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PSG7 Gene

Disorders for PSG7 Gene

Relevant External Links for PSG7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSG7

No disorders were found for PSG7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG7 Gene

Publications for PSG7 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 65
  2. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PMID: 7794280) Teglund S. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1995) 3 4 65
  3. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PMID: 1690992) Thompson J. … Hardman N. (Biochem. Biophys. Res. Commun. 1990) 3 4 65
  4. Expression and transcriptional regulation of individual pregnancy-specific glycoprotein genes in differentiating trophoblast cells. (PMID: 20116096) Camolotto S. … Panzetta-Dutari G.M. (Placenta 2010) 3 65
  5. Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence. (PMID: 18792801) Endoh M. … Ayusawa D. (Biogerontology 2009) 3 65

Products for PSG7 Gene

Sources for PSG7 Gene

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