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PSG6 Gene

protein-coding   GIFtS: 52
GCID: GC19M043406

Pregnancy Specific Beta-1-Glycoprotein 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pregnancy Specific Beta-1-Glycoprotein 61 2     PSG102 3
Pregnancy-Specific Beta-1-Glycoprotein 102 3     PSGGB2 3
Pregnancy-Specific Beta-1-Glycoprotein 122 3     Pregnancy-Specific Beta-1-Glycoprotein 62
PS-beta-G-102 3     CGM33
PS-beta-G-122 3     PSG123
PS-beta-G-62 3     Pregnancy-Specific Glycoprotein 103
PSBG-102 3     Pregnancy-Specific Glycoprotein 123
PSBG-122 3     Pregnancy-Specific Glycoprotein 63
PSBG-62 3     

External Ids:    HGNC: 95231   Entrez Gene: 56752   Ensembl: ENSG000001708487   OMIM: 1763955   UniProtKB: Q008893   

Export aliases for PSG6 gene to outside databases

Previous GC identifers: GC19M044053 GC19M043764 GC19M048082 GC19M048101 GC19M048102 GC19M048106 GC19M039837


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSG6 Gene:
This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of
the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at
19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental
trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for
maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated
with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein
isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for PSG6 Gene:
PSG6 (pregnancy specific beta-1-glycoprotein 6) is a protein-coding gene. An important paralog of this gene is PSG9.

Gene Wiki entry for PSG6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSG6 gene promoter:
         Sp1   POU3F1   c-Myb   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSG6 promoter sequence
   Search Chromatin IP Primers for PSG6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSG6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

PSG6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSG6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M043406:  view genomic region     (about GC identifiers)

Start:
43,406,231 bp from pter      End:
43,423,715 bp from pter
Size:
17,485 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PSG6_HUMAN, Q00889 (See protein sequence)
Recommended Name: Pregnancy-specific beta-1-glycoprotein 6 precursor  
Size: 435 amino acids; 48814 Da
Developmental stage: PSBG are produced in high quantity during pregnancy
Secondary accessions: O75244 Q15224 Q15235 Q549K1
Alternative splicing: 2 isoforms:  Q00889-1   Q00889-2   

Explore the universe of human proteins at neXtProt for PSG6: NX_Q00889

Explore proteomics data for PSG6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn61, Asn103, Asn110, Asn198, Asn267, Asn302, Asn386

  • See PSG6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001027020.1  NP_002773.1  

    ENSEMBL proteins: 
     ENSP00000187910   ENSP00000385736   ENSP00000472935   ENSP00000292125   ENSP00000470412  
     ENSP00000469423  

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    antibodies-online proteins for PSG6 (3 products) 

     
    antibodies-online peptides for PSG6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q00889

    ProtoNet protein and cluster: Q00889

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PSG6_HUMAN, Q00889
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with PSG6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for PSG6:
    pregnancy specific beta-1-glycoprotein 6,expressed by placental syncytiotrophoblasts,unknown
    function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PSG6           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PSG6:
     Decreased number of cells in m  Decreased viability of wild-ty  Decreased viability with pacli 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PSG6

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    miRTarBase miRNAs that target PSG6:
    hsa-mir-1 (MIRT023643)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSG6_HUMAN, Q00889: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS2271648

    Find genes that share ontologies with PSG6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSG6
    Interactions:

        Search GeneGlobe Interaction Network for PSG6

    1 Interacting protein for PSG6 (Q008893) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UTP14AQ9BVJ63I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007565female pregnancy NAS2271648

    Find genes that share ontologies with PSG6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSG6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSG6 gene (2 alternative transcripts): 
    NM_001031850.3  NM_002782.4  

    Unigene Cluster for PSG6:

    Pregnancy specific beta-1-glycoprotein 6
    Hs.646353  [show with all ESTs]
    Unigene Representative Sequence: NM_001031850
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000187910(uc002ovg.1 uc010xwk.1) ENST00000402603 ENST00000599753
    ENST00000292125(uc002ovj.1) ENST00000595062 ENST00000594375 ENST00000402456
    ENST00000484292 ENST00000601833
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    Additional mRNA sequence: 

    BC020652.1 M31125.1 M33666.1 X17098.1 

    Selected DOTS entries (see all 56):

    DT.91781716  DT.92047897  DT.95346291  DT.100870664  DT.91640597  DT.40268322  DT.91781730  DT.121424826 
    DT.40200671  DT.92413504  DT.91781707  DT.100829135  DT.100782815  DT.91695586  DT.95226587  DT.121424032 
    DT.121424757  DT.91781679  DT.92415484  DT.100762523  DT.100884402  DT.121424374  DT.316869  DT.86994642 

    Selected AceView cDNA sequences (see all 28):

    CR625118 T29368 CR605585 H62033 CR594229 CR623537 CR613711 CR596325 
    S59494 M34420 BE767902 M30628 M37399 BC005924 NM_021016 M27907 
    BG005643 AA368375 BG621332 BX097191 AA367500 BG434286 NM_002785 CR603900 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PSG6    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                    -     -     -     -     -         
    SP2:                                                      
    SP3:                                      -               


    ECgene alternative splicing isoforms for PSG6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSG6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTATTCATA
    PSG6 Expression
    About this image


    PSG6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Fibroblasts (Uncategorized)
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Placenta (Extraembryonic Tissues)
    PSG6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSG6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.646353
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for PSG6 (if available)
    TreeFam Gene Tree for PSG6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSG6 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
    PSG12  PSG52  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  PSG22  
    CEACAM162  PSG42  PSG72  CEACAM32  
    Selected SIMAP similar genes for PSG6 using alignment to 5 protein entries:     PSG6_HUMAN (see all proteins) (see all similar genes):
    PSG    DHFRP2    PSG11    PSG7    PSGII    PSG3
    PSG4    PSG5    PSG8    PSG1    SP1    PSG2
    PSG9    CEA    CEACAM7    CEACAM3    CEACAM4    CEACAM8

    Find genes that share paralogs with PSG6           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for PSG6
    PGOHUM00000234336 PGOHUM00000234338 PGOHUM00000259341 PGOHUM00000234705 PGOHUM00000234710


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSG6 (see all 985)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811966031,2
    --43405789(+) TACCAA/GTGGAT 1 -- ds50010--------
    rs1852889841,2
    --43405882(+) TCTCTA/GTAGGA 1 -- ds50010--------
    rs1382261041,2
    --43405990(+) GCAAGA/TGTAGC 1 -- ds50010--------
    rs1910702811,2
    --43405996(+) GTAGCA/CGTGGA 1 -- ds50010--------
    rs1824386071,2
    --43405997(+) TAGCCA/GTGGAC 1 -- ds50010--------
    rs1491526321,2
    C--43406004(+) GGACCA/GTAGAG 1 -- ds50010--------
    rs1432620851,2
    C--43406023(+) TAAACG/TTCCCT 1 -- ds50010--------
    rs1388089561,2
    C--43406026(+) ACGTCC/TCTTTG 1 -- ds50010--------
    rs1891446651,2
    --43406124(+) CCTGCA/TTTCCC 1 -- ds50010--------
    rs1918957941,2
    --43406135(+) TATGGA/GTTTAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PSG6 (43406231 - 43423715 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PSG6 (see all 76):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv15e196CNV Deletion17116639
    esv2422471CNV Deletion17116639
    esv2668787CNV Deletion23128226
    esv2718597CNV Deletion23290073
    dgv565e201CNV Deletion23290073
    esv2668472CNV Deletion23128226
    esv2718600CNV Deletion23290073
    esv2663048CNV Deletion23128226
    dgv564e201CNV Deletion23290073
    esv2718595CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176395    OMIM disorders: --


    Find genes that share disorders with PSG6           About GenesLikeMe


    Export disorders for PSG6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSG6 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with PSG6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PubMed id 1690992)1, 2, 3 Thompson J.... Hardman N. (Biochem. Biophys. Res. Commun. 1990)
    2. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PubMed id 2377620)1, 2, 9 Leslie K.K.... Chou J.Y. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. Characterization of cDNAs of the human pregnancy-specific beta-1- glycoprotein family, a new subfamily of the immunoglobulin gene superfamily. (PubMed id 2346748)1, 2 Zheng Q.-X.... Chan W.-Y. (Biochemistry 1990)
    6. Characterization of two new members of the pregnancy-specific beta 1- glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit. (PubMed id 2271648)1, 2 Barnett T.R.... Elting J.J. (Biochemistry 1990)
    7. cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. (PubMed id 2783133)1, 2 Zimmermann W.A.... Thompson J.A. (Biochem. Biophys. Res. Commun. 1989)
    8. Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons. (PubMed id 2537643)1, 2 Thompson J.A.... Zimmermann W. (Biochem. Biophys. Res. Commun. 1989)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5675 HGNC: 9523 AceView: PSG3 Ensembl:ENSG00000170848 euGenes: HUgn5675
    ECgene: PSG6 H-InvDB: PSG6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSG6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSG6 gene:
    Search GeneIP for patents involving PSG6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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