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Aliases for PSG6 Gene

Aliases for PSG6 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 6 2 3 5
  • Pregnancy-Specific Beta-1-Glycoprotein 10 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 12 3 4
  • PS-Beta-G-10 3 4
  • PS-Beta-G-12 3 4
  • PS-Beta-G-6 3 4
  • PSBG-10 3 4
  • PSBG-12 3 4
  • PSBG-6 3 4
  • PSG10 3 4
  • PSGGB 3 4
  • Pregnancy-Specific Glycoprotein 10 4
  • Pregnancy-Specific Glycoprotein 12 4
  • Pregnancy-Specific Glycoprotein 6 4
  • PSG12 4
  • CGM3 4

External Ids for PSG6 Gene

Previous GeneCards Identifiers for PSG6 Gene

  • GC19M044053
  • GC19M043764
  • GC19M048082
  • GC19M048101
  • GC19M048102
  • GC19M048106
  • GC19M043406
  • GC19M039837
  • GC19M042733

Summaries for PSG6 Gene

Entrez Gene Summary for PSG6 Gene

  • This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for PSG6 Gene

PSG6 (Pregnancy Specific Beta-1-Glycoprotein 6) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

Gene Wiki entry for PSG6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG6 Gene

Genomics for PSG6 Gene

Regulatory Elements for PSG6 Gene

Enhancers for PSG6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSG6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG6 Gene

Chromosome:
19
Start:
42,902,079 bp from pter
End:
42,919,563 bp from pter
Size:
17,485 bases
Orientation:
Minus strand

Genomic View for PSG6 Gene

Genes around PSG6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG6 Gene

Proteins for PSG6 Gene

  • Protein details for PSG6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00889-PSG6_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 6
    Protein Accession:
    Q00889
    Secondary Accessions:
    • O75244
    • Q15224
    • Q15235
    • Q549K1

    Protein attributes for PSG6 Gene

    Size:
    435 amino acids
    Molecular mass:
    48814 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PSG6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSG6 Gene

Proteomics data for PSG6 Gene at MOPED

Post-translational modifications for PSG6 Gene

  • Glycosylation at Asn 61, Asn 103, Asn 110, Asn 198, Asn 267, Asn 302, and Asn 386
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG6 Gene

Antibody Products

No data available for DME Specific Peptides for PSG6 Gene

Domains & Families for PSG6 Gene

Protein Domains for PSG6 Gene

Suggested Antigen Peptide Sequences for PSG6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00889

UniProtKB/Swiss-Prot:

PSG6_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG6: view

Function for PSG6 Gene

Molecular function for PSG6 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 6,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily
genes like me logo Genes that share phenotypes with PSG6: view

Animal Model Products

CRISPR Products

miRNA for PSG6 Gene

miRTarBase miRNAs that target PSG6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG6 Gene

Localization for PSG6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSG6 Gene COMPARTMENTS Subcellular localization image for PSG6 gene
Compartment Confidence
extracellular 5
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PSG6 Gene

Pathways & Interactions for PSG6 Gene

SuperPathways for PSG6 Gene

No Data Available

Interacting Proteins for PSG6 Gene

Selected Interacting proteins: Q00889-PSG6_HUMAN for PSG6 Gene via I2D

Symbol External ID(s) Details
UTP14A

Gene Ontology (GO) - Biological Process for PSG6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PSG6 Gene

Drugs & Compounds for PSG6 Gene

No Compound Related Data Available

Transcripts for PSG6 Gene

Unigene Clusters for PSG6 Gene

Pregnancy specific beta-1-glycoprotein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSG6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - - - -
SP2:
SP3: -

Relevant External Links for PSG6 Gene

GeneLoc Exon Structure for
PSG6
ECgene alternative splicing isoforms for
PSG6

Expression for PSG6 Gene

mRNA expression in normal human tissues for PSG6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG6 Gene

This gene is overexpressed in Testis (x12.4).

Protein differential expression in normal tissues from HIPED for PSG6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG6 Gene



SOURCE GeneReport for Unigene cluster for PSG6 Gene Hs.646353

genes like me logo Genes that share expression patterns with PSG6: view

Protein tissue co-expression partners for PSG6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PSG6 Gene

Orthologs for PSG6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100612876 35
  • 92.41 (n)
  • 86.44 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 26 (a)
ManyToMany
CEACAM1 36
  • 33 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg21 36
  • 21 (a)
ManyToMany
Species with no ortholog for PSG6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG6 Gene

ENSEMBL:
Gene Tree for PSG6 (if available)
TreeFam:
Gene Tree for PSG6 (if available)

Paralogs for PSG6 Gene

genes like me logo Genes that share paralogs with PSG6: view

Variants for PSG6 Gene

Sequence variations from dbSNP and Humsavar for PSG6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1058674 - 42,910,821(-) AACTT(A/C)AACCC reference, missense
rs1058680 - 42,910,792(-) TGTGC(A/G/T)CTTAA reference, missense
rs1065505 - 42,910,786(-) CTTAA(C/T)CTGTG reference, missense
rs1065507 - 42,910,747(-) GTGGT(G/T)GCTGA reference, missense
rs1065508 - 42,910,745(-) GGTTG(A/C)TGAAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PSG6 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV Deletion 17116639
dgv15e196 CNV Deletion 17116639
dgv1086e1 CNV Complex 17122850
dgv1087e1 CNV Complex 17122850
dgv1088e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
nsv833835 CNV Gain 17160897
nsv428364 CNV Gain+Loss 18775914
dgv3890n71 CNV Gain 21882294
dgv1089e1 CNV Complex 17122850
dgv141e55 CNV Loss 17911159
dgv3891n71 CNV Gain 21882294
esv33217 CNV Loss 17666407
dgv1090e1 CNV Complex 17122850
nsv828554 CNV Gain 20364138
dgv3893n71 CNV Loss 21882294
dgv3894n71 CNV Gain 21882294
dgv3895n71 CNV Loss 21882294
nsv2497 CNV Loss 18451855
nsv470143 CNV Gain 18288195
dgv409n27 CNV Loss 19166990
dgv410n27 CNV Gain 19166990
dgv411n27 CNV Loss 19166990
dgv142e55 CNV Loss 17911159
esv2663048 CNV Deletion 23128226
nsv911820 CNV Gain+Loss 21882294
dgv3896n71 CNV Loss 21882294
dgv3897n71 CNV Gain+Loss 21882294
nsv911839 CNV Gain+Loss 21882294
dgv3898n71 CNV Loss 21882294
dgv589n67 CNV Loss 20364138
nsv442766 CNV CNV 18776908
dgv1091e1 CNV Complex 17122850
dgv3899n71 CNV Loss 21882294
dgv3900n71 CNV Gain 21882294
esv22277 CNV Gain+Loss 19812545
esv2421673 OTHER Complex 20811451
dgv3901n71 CNV Loss 21882294
esv2668472 CNV Deletion 23128226
esv2718595 CNV Deletion 23290073
nsv817842 CNV Gain+Loss 17921354
nsv817843 CNV Gain 17921354
nsv470145 CNV Loss 18288195
dgv3902n71 CNV Loss 21882294
dgv3903n71 CNV Loss 21882294
essv17365 CNV CNV 17122850
dgv3904n71 CNV Gain+Loss 21882294
dgv3905n71 CNV Gain 21882294
dgv3906n71 CNV Loss 21882294
esv2718597 CNV Deletion 23290073
dgv3907n71 CNV Gain 21882294
dgv3908n71 CNV Loss 21882294
dgv565e201 CNV Deletion 23290073
nsv911910 CNV Gain 21882294
dgv3909n71 CNV Gain+Loss 21882294
dgv3910n71 CNV Loss 21882294
dgv3911n71 CNV Gain+Loss 21882294
dgv3912n71 CNV Loss 21882294
dgv3913n71 CNV Loss 21882294
dgv412n27 CNV Gain 19166990
dgv413n27 CNV Loss 19166990
dgv414n27 CNV Gain 19166990
dgv415n27 CNV Gain 19166990
dgv416n27 CNV Loss 19166990
dgv3914n71 CNV Loss 21882294
dgv3915n71 CNV Loss 21882294
dgv3916n71 CNV Loss 21882294
nsv471410 CNV Duplication 19718026
nsv482040 CNV Gain 20164927
esv2718600 CNV Deletion 23290073
esv2668787 CNV Deletion 23128226
nsv911980 CNV Loss 21882294
nsv458650 CNV Loss 19166990

Variation tolerance for PSG6 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSG6 Gene

HapMap Linkage Disequilibrium report
PSG6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG6 Gene

Disorders for PSG6 Gene

Relevant External Links for PSG6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSG6

No disorders were found for PSG6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG6 Gene

Publications for PSG6 Gene

  1. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PMID: 1690992) Thompson J. … Hardman N. (Biochem. Biophys. Res. Commun. 1990) 2 3 4 67
  2. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PMID: 2377620) Leslie K.K. … Chou J.Y. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3

Products for PSG6 Gene

Sources for PSG6 Gene

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