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Aliases for PSG5 Gene

Aliases for PSG5 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 5 2 3 5
  • Fetal Liver Non-Specific Cross-Reactive Antigen 3 3 4
  • Pregnancy-Specific Beta-1 Glycoprotein 2 3
  • Pregnancy-Specific Beta 1 Glycoprotein 2 3
  • Pregnancy-Specific Glycoprotein 5 3 4
  • PS-Beta-G-5 3 4
  • FL-NCA-3 3 4
  • PSBG-5 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein-5 3
  • PSG 3

External Ids for PSG5 Gene

Previous GeneCards Identifiers for PSG5 Gene

  • GC19M044320
  • GC19M044063
  • GC19M048105
  • GC19M048100
  • GC19M048287
  • GC19M048103
  • GC19M048366
  • GC19M047920
  • GC19M043670
  • GC19M040101
  • GC19M043166

Summaries for PSG5 Gene

Entrez Gene Summary for PSG5 Gene

  • The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG5 Gene

PSG5 (Pregnancy Specific Beta-1-Glycoprotein 5) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

Gene Wiki entry for PSG5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG5 Gene

Genomics for PSG5 Gene

Regulatory Elements for PSG5 Gene

Promoters for PSG5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSG5 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG5 Gene

Chromosome:
19
Start:
43,032,810 bp from pter
End:
43,186,536 bp from pter
Size:
153,727 bases
Orientation:
Minus strand

Genomic View for PSG5 Gene

Genes around PSG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG5 Gene

Proteins for PSG5 Gene

  • Protein details for PSG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15238-PSG5_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 5
    Protein Accession:
    Q15238
    Secondary Accessions:
    • Q15239
    • Q96QJ1
    • Q9UQ75

    Protein attributes for PSG5 Gene

    Size:
    335 amino acids
    Molecular mass:
    37713 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSG5 Gene

Proteomics data for PSG5 Gene at MOPED

Post-translational modifications for PSG5 Gene

  • Glycosylation at Asn 104, Asn 111, Asn 175, and Asn 210
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG5 Gene

Antibody Products

No data available for DME Specific Peptides for PSG5 Gene

Domains & Families for PSG5 Gene

Protein Domains for PSG5 Gene

Suggested Antigen Peptide Sequences for PSG5 Gene

Graphical View of Domain Structure for InterPro Entry

Q15238

UniProtKB/Swiss-Prot:

PSG5_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG5: view

Function for PSG5 Gene

Molecular function for PSG5 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 5,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily
genes like me logo Genes that share phenotypes with PSG5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PSG5 Gene

Localization for PSG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSG5 Gene COMPARTMENTS Subcellular localization image for PSG5 gene
Compartment Confidence
extracellular 4
nucleus 2
cytosol 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PSG5 Gene

Pathways & Interactions for PSG5 Gene

SuperPathways for PSG5 Gene

No Data Available

Interacting Proteins for PSG5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000344413%0d%0a9606.ENSP00000361554%0d%0a
Selected Interacting proteins: ENSP00000344413 Q15238-PSG5_HUMAN for PSG5 Gene via STRING UniProtKB MINT I2D

Gene Ontology (GO) - Biological Process for PSG5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PSG5 Gene

Drugs & Compounds for PSG5 Gene

No Compound Related Data Available

Transcripts for PSG5 Gene

Unigene Clusters for PSG5 Gene

Pregnancy specific beta-1-glycoprotein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSG5 Gene

No ASD Table

Relevant External Links for PSG5 Gene

GeneLoc Exon Structure for
PSG5
ECgene alternative splicing isoforms for
PSG5

Expression for PSG5 Gene

mRNA expression in normal human tissues for PSG5 Gene

Protein differential expression in normal tissues from HIPED for PSG5 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG5 Gene



SOURCE GeneReport for Unigene cluster for PSG5 Gene Hs.654415

mRNA Expression by UniProt/SwissProt for PSG5 Gene

Q15238-PSG5_HUMAN
Tissue specificity: Synthesized by syncytiotrophoblast of the placenta.
genes like me logo Genes that share expression patterns with PSG5: view

Protein tissue co-expression partners for PSG5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PSG5 Gene

Orthologs for PSG5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 73 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 19 (a)
ManyToMany
CEACAM1 36
  • 22 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg22 36
  • 17 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
ManyToMany
Species with no ortholog for PSG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG5 Gene

ENSEMBL:
Gene Tree for PSG5 (if available)
TreeFam:
Gene Tree for PSG5 (if available)

Paralogs for PSG5 Gene

genes like me logo Genes that share paralogs with PSG5: view

Variants for PSG5 Gene

Sequence variations from dbSNP and Humsavar for PSG5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1058259 - 43,176,117(-) ATCAA(C/G)AACTC reference, missense
rs8107936 - 43,186,354(+) CAGGA(C/G)CCCCT reference, missense
rs5013158 - 43,176,076(+) CACAG(A/G)TGAAG reference, missense
rs1058285 - 43,175,899(-) CATGC(A/G)CAGTG reference, missense
rs15909 -- 43,182,898(-) CTGCC(A/G)GGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSG5 Gene

Variant ID Type Subtype PubMed ID
dgv1087e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
dgv1089e1 CNV Complex 17122850
dgv141e55 CNV Loss 17911159
dgv3891n71 CNV Gain 21882294
nsv470143 CNV Gain 18288195
dgv411n27 CNV Loss 19166990
esv2663048 CNV Deletion 23128226
dgv3898n71 CNV Loss 21882294
esv22277 CNV Gain+Loss 19812545
nsv470145 CNV Loss 18288195
dgv565e201 CNV Deletion 23290073
dgv415n27 CNV Gain 19166990
dgv416n27 CNV Loss 19166990
dgv417n27 CNV Loss 19166990
esv2751794 CNV Gain 17911159
dgv3921n71 CNV Loss 21882294
esv2421574 OTHER Complex 20811451
nsv912001 CNV Gain 21882294
nsv833837 CNV Gain 17160897
dgv1092e1 CNV Complex 17122850
dgv3925n71 CNV Gain 21882294
dgv420n27 CNV Loss 19166990
dgv421n27 CNV Gain 19166990
nsv437832 CNV Loss 16327808
esv2657641 CNV Deletion 23128226
dgv1093e1 CNV Complex 17122850
nsv817844 CNV Loss 17921354
dgv1094e1 CNV Complex 17122850
dgv3929n71 CNV Gain 21882294
dgv3930n71 CNV Gain 21882294
esv2718603 CNV Deletion 23290073
nsv912041 CNV Loss 21882294
nsv912042 CNV Gain+Loss 21882294
nsv912046 CNV Gain+Loss 21882294
dgv3932n71 CNV Gain 21882294
esv2751795 CNV Loss 17911159
dgv422n27 CNV Loss 19166990
nsv817846 CNV Gain+Loss 17921354
dgv3933n71 CNV Gain 21882294
dgv3934n71 CNV Loss 21882294
dgv3936n71 CNV Gain 21882294
dgv3937n71 CNV Loss 21882294
esv2671292 CNV Deletion 23128226
esv2671788 CNV Deletion 23128226
dgv3938n71 CNV Gain 21882294
dgv3939n71 CNV Loss 21882294
dgv3940n71 CNV Gain+Loss 21882294
dgv3941n71 CNV Loss 21882294
dgv1095e1 CNV Complex 17122850
nsv833838 CNV Gain 17160897
dgv1096e1 CNV Complex 17122850
nsv458703 CNV Gain 19166990
nsv912096 CNV Gain+Loss 21882294
nsv437833 CNV Loss 16327808
dgv3942n71 CNV Gain 21882294
esv2718604 CNV Deletion 23290073
esv7692 CNV Loss 19470904
nsv912105 CNV Gain 21882294
essv22369 CNV CNV 17122850
nsv458704 CNV Loss 19166990
nsv437182 CNV Loss 16327808
dgv1097e1 CNV Complex 17122850
dgv1098e1 CNV Complex 17122850
nsv458705 CNV Loss 19166990
nsv817848 CNV Loss 17921354
dgv1099e1 CNV Complex 17122850
dgv1100e1 CNV Complex 17122850
dgv1101e1 CNV Complex 17122850
nsv471413 CNV Duplication 19718026
nsv482043 CNV Gain 20164927
esv34676 CNV Loss 17911159
nsv828557 CNV Loss 20364138
nsv2499 CNV Loss 18451855
dgv590n67 CNV Loss 20364138
esv33039 CNV Gain 17666407

Variation tolerance for PSG5 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.82; 86.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSG5 Gene

HapMap Linkage Disequilibrium report
PSG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG5 Gene

Disorders for PSG5 Gene

Relevant External Links for PSG5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSG5

No disorders were found for PSG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG5 Gene

Publications for PSG5 Gene

  1. Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement. (PMID: 2735907) Khan W.N. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1989) 2 3 4 67
  2. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PMID: 7794280) Teglund S. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1995) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins. (PMID: 23418492) Camolotto S.A. … Panzetta-Dutari G.M. (PLoS ONE 2013) 3
  5. Pregnancy-specific glycoproteins bind integrin I+IIbI^3 and inhibit the platelet-fibrinogen interaction. (PMID: 23469002) Shanley D.K. … Moore T. (PLoS ONE 2013) 3

Products for PSG5 Gene

Sources for PSG5 Gene

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