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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSG5 Gene

protein-coding   GIFtS: 48
GCID: GC19M043670

pregnancy specific beta-1-glycoprotein 5
 Explore 1 disease affiliated with
PSG5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PSG5    

Aliases
for PSG5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pregnancy Specific Beta-1-Glycoprotein 51 2     PSBG-52 3
FL-NCA-31 2 3     Pregnancy-Specific Beta 1 Glycoprotein2
PSG1 2     Pregnancy-Specific Beta-1 Glycoprotein2
Fetal Liver Non-Specific Cross-Reactive Antigen 32 3     Pregnancy-Specific Beta-1-Glycoprotein 52
Pregnancy-Specific Glycoprotein 52 3     Pregnancy-Specific Beta-1-Glycoprotein-52
PS-Beta-G-51     

External Ids:    HGNC: 95221   Entrez Gene: 56732   Ensembl: ENSG000002049417   OMIM: 1763945   UniProtKB: Q152383   

Export aliases for PSG5 gene to outside databases

Previous GC identifers: GC19M044320 GC19M044063 GC19M048105 GC19M048100 GC19M048287 GC19M048103 GC19M048366 GC19M047920 GC19M040101


Summaries
for PSG5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PSG5:
The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental
syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which
belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM
176390).(supplied by OMIM, Oct 2009)

Gene Wiki entry for PSG5


Genomic Views
for PSG5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSG5 gene promoter:
         c-Fos   AP-1   POU3F1   Pax-2   c-Jun   Pax-2a   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSG5 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSG5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

PSG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSG5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M043670:  view genomic region     (about GC identifiers)

Start:
 43,670,408 bp from pter      End:
 43,690,688 bp from pter
Size:
 20,281 bases      Orientation:
 minus strand

Proteins
for PSG5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PSG5_HUMAN, Q15238 (See protein sequence)
Recommended Name: Pregnancy-specific beta-1-glycoprotein 5 precursor  
Size: 335 amino acids; 37713 Da
Subcellular location: Secreted (Potential)
Developmental stage: PSBG are produced in high quantity during pregnancy
Secondary accessions: Q15239 Q96QJ1 Q9UQ75

Explore the universe of human proteins at neXtProt for PSG5: NX_Q15238

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15238

    • PSG5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123486.1  NP_002772.3  

    ENSEMBL proteins: 
     ENSP00000382334   ENSP00000386008   ENSP00000386053   ENSP00000344413   ENSP00000385250  
     ENSP00000384649  

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    Novus Biologicals PSG5 Protein
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    Uscn Proteins for PSG5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    PSG5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PSG5

    Protein Domains /
    Families
    for PSG5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSG5 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q15238

    ProtoNet protein and cluster: Q15238

    2 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PSG5_HUMAN, Q15238
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for PSG5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for PSG5:
    pregnancy specific beta-1-glycoprotein 5,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic
    antigen (CEA family),immunoglobulin superfamily

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for PSG5

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    PSG5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PSG5:
     Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for PSG5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSG5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for PSG5 (Q152381, 2, 3 ENSP000003444134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61854 I2D: score=3 
    TIE1P355901, ENSP000003615544EBI-4314891,EBI-2256865 STRING: ENSP00000361554
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007565female pregnancy TAS1690992


    PSG5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSG5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSG5
    Search CenterWatch for drugs/clinical trials and news about PSG5 

    Transcripts
    for PSG5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PSG5 gene (2 alternative transcripts): 
    NM_001130014.1  NM_002781.3  

    Unigene Cluster for PSG5:

    Pregnancy specific beta-1-glycoprotein 5
    Hs.654415  [show with all ESTs]
    Unigene Representative Sequence: NM_002781
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366175 ENST00000436999 ENST00000407356 ENST00000407568 ENST00000342951(uc002ovu.3 uc002ovx.3)
    ENST00000404580 ENST00000481294 ENST00000489220 ENST00000401992

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC012607.1 L36607.1 M25384.1 M73713.1 

    24/50 DOTS entries (see all 50):

    DT.87077474  DT.100799889  DT.91742662  DT.95375832  DT.121424672  DT.100784604  DT.91933184  DT.100759600 
    DT.121424834  DT.40123361  DT.91714482  DT.121424177  DT.121424560  DT.121424891  DT.92421520  DT.100784602 
    DT.91806732  DT.95305262  DT.100784597  DT.121424427  DT.121424748  DT.110610  DT.453453  DT.95375827 

    17 AceView cDNA sequences:

    CR592362 D59036 CR606280 CR607340 CR612136 CR625219 CR605183 CR621678 
    CR609451 CR595886 BF111910 BG009533 AL573460 NM_002781 BQ366854 CR592867 
    CR592773 

    GeneLoc Exon Structure


    Expression
    for PSG5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PSG5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PSG5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSG5

    SOURCE GeneReport for Unigene cluster: Hs.654415

    UniProtKB/Swiss-Prot: PSG5_HUMAN, Q15238
    Tissue specificity: Synthesized by syncytiotrophoblast of the placenta

        SABiosciences Custom PCR Arrays for PSG5
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PSG5

    Orthologs
    for PSG5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PSG5 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 11(a)
    		 possible ortholog
    		 GL344292.1(1263-21096)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-250k15.76
    si:dkey-250k15.106
    (see all 9)    		 si:dkey-250k15.10
    (see all 9)    		 6(a)
    5(a)
    (see all 9)    		 possible ortholog
    possible ortholog
    (see all 9)    		 16(13433555-13459598)
    16(13410869-13430977)


    ENSEMBL Gene Tree for PSG5 (if available)
    TreeFam Gene Tree for PSG5 (if available) 

    Paralogs
    for PSG5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSG5 gene
    PSG92  PSG82  CEACAM52  CEACAM42  PSG112  CEACAM72  PSG32  CEACAM212  
    PSG12  PSG62  CEACAM12  CEACAM82  CEACAM62  PSG22  CEACAM182  CEACAM162  
    PSG42  CEACAM32  
    18/25 SIMAP similar genes for PSG5 using alignment to 6 protein entries:     PSG5_HUMAN (see all proteins) (see all similar genes):
    PSG    PSGII    DHFRP2    PSG2    PSG8    PSG1
    PSG11    PSG6    PSG9    PSG4    PSG3    PSG7
    CEACAM8    SP1    CEA    CEACAM3    CEACAM6    CEACAM1

    PSG5 for paralogs           About GeneDecksing



    Genomic Variants
    for PSG5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/735 NCBI SNPs in PSG5 are shown (see all 735)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1505874411,2
    		C,Fother43679421(+) GTTACG/AAACAG 4 /R /C mis12Minor allele frequency- A:0.00NA EU 5857
    rs1995392111,2
    		--43671417(+) GAACT-/AAAAGA 2 -- int10--------
    rs1884012961,2
    		--43671547(+) GGAGTC/TTCTAT 2 -- int10--------
    rs1811860281,2
    		--43671595(+) GCAAAA/TTAGGT 2 -- int10--------
    rs1866279001,2
    		--43671597(+) AAAATA/TGGTTG 2 -- int10--------
    rs1914195351,2
    		--43671610(+) TCTCAC/GCGAAC 2 -- int10--------
    rs1836955281,2
    		--43671611(+) CTCACC/TGAACT 2 -- int10--------
    rs1481412131,2
    		C,--43671626(+) CAGATA/TTTTTA 2 -- int10--------
    rs1860527891,2
    		--43671632(+) TTTTAC/GCTAAG 2 -- int10--------
    rs1429285011,2
    		--43671640(+) AAGTGA/CGGAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for PSG5 (43670408 - 43690688 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 46 variations for PSG5
         15/46 CNVs (see all 46): 8873 53699 10561 35649 34649 50174 5102 53957 1301 50163 53934 30079 89254 34617 50155

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSG5
    DNA2.0 Custom Variant and Variant Library Synthesis for PSG5

    Disorders / Diseases
    for PSG5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSG5 for disorders           About GeneDecksing

    OMIM gene information: 176394    OMIM disorders: --

    1 disease for PSG5:    About MalaCards
    leukemia

    1 Novoseek disease relationship for PSG5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 7690349 (1)


    Export disorders for PSG5 gene to outside databases

    Publications
    for PSG5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSG5 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with PSG5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement. (PubMed id 2735907)1, 2, 3 Khan W.N. and Hammarstroem S. (1989)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Characterization of new members of the pregnancy-specific beta 1- glycoprotein family. (PubMed id 1922019)1, 2 Chan W.Y.... Tease L.A. (1991)
    4. A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene. (PubMed id 2789512)1, 2 Oikawa S.... Nakazato H. (1989)
    5. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PubMed id 7794280)1, 9 Teglund S.... Hammarstroem S. (1995)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Placenta-derived, cellular messenger RNA expression in the maternal blood of preeclamptic women. (PubMed id 17978129)1 Okazaki S....Okai T. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1. (PubMed id 16563348)1 Blanchon L....Sapin V. (2006)

    External Searches for PSG5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PSG5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5673 HGNC: 9522 AceView: PSG5 Ensembl:ENSG00000204941 euGenes: HUgn5673
    ECgene: PSG5 H-InvDB: PSG5

    Other Databases showing PSG5 gene

    (According to HUGE)
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    Specialized Databases showing PSG5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSG5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PSG5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PSG5 gene:
    Search GeneIP for patents involving PSG5

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