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Aliases for PSG5 Gene

Aliases for PSG5 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 5 2 3 5
  • Fetal Liver Non-Specific Cross-Reactive Antigen 3 3 4
  • Pregnancy-Specific Beta 1 Glycoprotein 2 3
  • Pregnancy-Specific Glycoprotein 5 3 4
  • PS-Beta-G-5 3 4
  • FL-NCA-3 3 4
  • PSBG-5 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein-5 3
  • Pregnancy-Specific Beta-1-Glycoprotein 5 3
  • Pregnancy-Specific Beta-1 Glycoprotein 2
  • PSG 3

External Ids for PSG5 Gene

Previous GeneCards Identifiers for PSG5 Gene

  • GC19M044320
  • GC19M044063
  • GC19M048105
  • GC19M048100
  • GC19M048287
  • GC19M048103
  • GC19M048366
  • GC19M047920
  • GC19M043670
  • GC19M040101
  • GC19M043166

Summaries for PSG5 Gene

Entrez Gene Summary for PSG5 Gene

  • The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG5 Gene

PSG5 (Pregnancy Specific Beta-1-Glycoprotein 5) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is PSG3.

Gene Wiki entry for PSG5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG5 Gene

Genomics for PSG5 Gene

Regulatory Elements for PSG5 Gene

Enhancers for PSG5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F043180 0.5 Ensembl ENCODE 16.9 +2.5 2450 6.4 SIN3A FEZF1 GLI4 ZNF2 ZNF121 GLIS2 FOS SP3 YY2 ZNF518A PSG4 ZNF526 ZNF45 ZNF155 ZNF234 PSG5 ZNF225 XRCC1 ENSG00000231412 LOC100421300
GH19F043263 1.3 Ensembl ENCODE 11.1 -80.2 -80233 5.7 HDGF PKNOX1 FEZF1 FOS SP3 TSHZ1 ZNF623 ZNF592 ZNF264 SMARCA4 ZNF45 ZNF234 PSG4 ZNF155 ZNF225 ZNF224 PSG5 ZNF284 XRCC1 ENSG00000231412
GH19F043147 0.2 ENCODE 10.6 +37.9 37945 1.9 PKNOX1 ZNF493 ARID4B DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 ZNF766 ZNF143 PSG4 ZNF225 PSG5 IRGQ ZNF45 ENSG00000227606 GC19P043117
GH19F043200 0.5 Ensembl ENCODE 6.4 -16.7 -16664 6.2 ZNF493 ZFP64 ARID4B DMAP1 FEZF1 GLI4 ZNF48 ZNF121 ZNF302 ZNF416 ZNF45 ZNF224 ZNF225 ZNF526 ZNF234 ZNF284 PSG4 XRCC1 ZNF230 IRGQ
GH19F043126 1 Ensembl ENCODE 4.6 +58.1 58127 3.6 BCOR CTCF ESRRA ZNF362 ZSCAN18 L3MBTL2 ZMYM3 HIC1 JUND ZNF366 ENSG00000231412 PSG4 PSG5 GC19P043117 ENSG00000227606
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PSG5 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG5 Gene

43,032,810 bp from pter
43,186,536 bp from pter
153,727 bases
Minus strand

Genomic View for PSG5 Gene

Genes around PSG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG5 Gene

Proteins for PSG5 Gene

  • Protein details for PSG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 5
    Protein Accession:
    Secondary Accessions:
    • Q15239
    • Q96QJ1
    • Q9UQ75

    Protein attributes for PSG5 Gene

    335 amino acids
    Molecular mass:
    37713 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSG5 Gene

Post-translational modifications for PSG5 Gene

  • Glycosylation at Asn 104, Asn 111, Asn 175, and Asn 210
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSG5 Gene

Domains & Families for PSG5 Gene

Suggested Antigen Peptide Sequences for PSG5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG5: view

Function for PSG5 Gene

Molecular function for PSG5 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 5,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Gene Ontology (GO) - Molecular Function for PSG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with PSG5: view
genes like me logo Genes that share phenotypes with PSG5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PSG5 Gene

Localization for PSG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG5 Gene


Subcellular locations from

Jensen Localization Image for PSG5 Gene COMPARTMENTS Subcellular localization image for PSG5 gene
Compartment Confidence
extracellular 4
nucleus 2
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PSG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSG5: view

Pathways & Interactions for PSG5 Gene

genes like me logo Genes that share pathways with PSG5: view

Pathways by source for PSG5 Gene

Gene Ontology (GO) - Biological Process for PSG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS 1690992
genes like me logo Genes that share ontologies with PSG5: view

No data available for SIGNOR curated interactions for PSG5 Gene

Transcripts for PSG5 Gene

Unigene Clusters for PSG5 Gene

Pregnancy specific beta-1-glycoprotein 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSG5 Gene

No ASD Table

Relevant External Links for PSG5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSG5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSG5 Gene

Protein differential expression in normal tissues from HIPED for PSG5 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG5 Gene

Protein tissue co-expression partners for PSG5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PSG5 Gene:


SOURCE GeneReport for Unigene cluster for PSG5 Gene:


mRNA Expression by UniProt/SwissProt for PSG5 Gene:

Tissue specificity: Synthesized by syncytiotrophoblast of the placenta.
genes like me logo Genes that share expression patterns with PSG5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PSG5 Gene

Orthologs for PSG5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 73 (a)
(Bos Taurus)
Mammalia CEACAM1 35
  • 22 (a)
-- 35
  • 19 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 17 (a)
(Mus musculus)
Mammalia Psg22 35
  • 17 (a)
Species where no ortholog for PSG5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG5 Gene

Gene Tree for PSG5 (if available)
Gene Tree for PSG5 (if available)

Paralogs for PSG5 Gene

Variants for PSG5 Gene

Sequence variations from dbSNP and Humsavar for PSG5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10407588 -- 43,169,390(+) GGTGT(C/G)GTTAA intron-variant
rs10408535 -- 43,185,442(+) CCCCC(A/C)ACACT intron-variant
rs10408657 -- 43,178,303(+) TCCCT(C/T)TATGT intron-variant
rs10410967 -- 43,173,184(+) gagtg(A/G)aacct intron-variant
rs10411703 -- 43,172,962(+) acact(C/T)cctga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSG5 Gene

Variant ID Type Subtype PubMed ID
dgv140e55 CNV gain 17911159
dgv141e55 CNV loss 17911159
dgv143n111 CNV deletion 26073780
dgv1786n106 CNV tandem duplication 24896259
dgv3557n100 CNV gain 25217958
dgv3566n100 CNV gain 25217958
dgv3571n100 CNV loss 25217958
dgv3572n100 CNV gain+loss 25217958
dgv3577n100 CNV gain 25217958
dgv3582n100 CNV gain 25217958
dgv3583n100 CNV loss 25217958
dgv3584n100 CNV gain 25217958
dgv3585n100 CNV loss 25217958
dgv3587n100 CNV gain 25217958
dgv3588n100 CNV gain 25217958
dgv3589n100 CNV loss 25217958
dgv3590n100 CNV gain+loss 25217958
dgv3591n100 CNV loss 25217958
dgv3592n100 CNV loss 25217958
dgv3593n100 CNV gain 25217958
dgv3594n100 CNV gain 25217958
dgv3595n100 CNV gain 25217958
dgv3596n100 CNV gain+loss 25217958
dgv3597n100 CNV loss 25217958
dgv3598n100 CNV loss 25217958
dgv411n27 CNV loss 19166990
dgv415n27 CNV gain 19166990
dgv416n27 CNV loss 19166990
dgv417n27 CNV loss 19166990
dgv420n27 CNV loss 19166990
dgv421n27 CNV gain 19166990
dgv422n27 CNV loss 19166990
dgv523e201 CNV deletion 23290073
dgv524e201 CNV deletion 23290073
dgv590n67 CNV loss 20364138
dgv6466n54 CNV gain 21841781
dgv6467n54 CNV loss 21841781
dgv6471n54 CNV loss 21841781
dgv6474n54 CNV loss 21841781
dgv6480n54 CNV gain+loss 21841781
dgv6485n54 CNV loss 21841781
dgv6488n54 CNV gain 21841781
dgv6491n54 CNV loss 21841781
dgv6492n54 CNV gain 21841781
dgv6493n54 CNV loss 21841781
dgv6494n54 CNV loss 21841781
dgv6495n54 CNV gain+loss 21841781
dgv6496n54 CNV loss 21841781
dgv6497n54 CNV loss 21841781
dgv662e214 CNV loss 21293372
dgv73e203 CNV gain+loss 21179565
esv22277 CNV gain+loss 19812545
esv2421574 OTHER complex 20811451
esv2657641 CNV deletion 23128226
esv2663048 CNV deletion 23128226
esv2671292 CNV deletion 23128226
esv2671788 CNV deletion 23128226
esv2718603 CNV deletion 23290073
esv2718604 CNV deletion 23290073
esv2751794 CNV gain 17911159
esv2751795 CNV loss 17911159
esv2758763 CNV gain+loss 17122850
esv33039 CNV gain 17666407
esv34676 CNV loss 17911159
esv3556434 CNV deletion 23714750
esv3644411 CNV loss 21293372
esv3644445 CNV loss 21293372
esv3644447 CNV loss 21293372
esv3644448 CNV loss 21293372
esv3644449 CNV gain 21293372
esv3644450 CNV loss 21293372
esv3893213 CNV gain 25118596
esv3893216 CNV gain+loss 25118596
esv3893217 CNV gain 25118596
esv3893218 CNV gain+loss 25118596
esv3893219 CNV loss 25118596
esv7692 CNV loss 19470904
nsv1055792 CNV loss 25217958
nsv1057657 CNV gain 25217958
nsv1057839 CNV gain 25217958
nsv1059308 CNV gain+loss 25217958
nsv1061699 CNV loss 25217958
nsv1064376 CNV gain 25217958
nsv1064459 CNV loss 25217958
nsv1064717 CNV gain+loss 25217958
nsv1123257 CNV deletion 24896259
nsv1140446 CNV deletion 24896259
nsv1153047 CNV deletion 26484159
nsv2499 CNV deletion 18451855
nsv437182 CNV loss 16327808
nsv437832 CNV loss 16327808
nsv437833 CNV loss 16327808
nsv458703 CNV gain 19166990
nsv458704 CNV loss 19166990
nsv458705 CNV loss 19166990
nsv470143 CNV gain 18288195
nsv470145 CNV loss 18288195
nsv471413 CNV gain 19718026
nsv482043 CNV gain 20164927
nsv510925 OTHER complex 20534489
nsv516973 CNV gain+loss 19592680
nsv579736 CNV gain 21841781
nsv579759 CNV loss 21841781
nsv579779 CNV loss 21841781
nsv579780 CNV gain+loss 21841781
nsv579787 CNV loss 21841781
nsv579809 CNV gain 21841781
nsv579815 CNV loss 21841781
nsv579820 CNV loss 21841781
nsv817844 CNV loss 17921354
nsv817846 CNV gain+loss 17921354
nsv817848 CNV loss 17921354
nsv828557 CNV loss 20364138
nsv833837 CNV gain 17160897
nsv833838 CNV gain 17160897
nsv963056 CNV duplication 23825009
nsv9730 CNV gain+loss 18304495

Variation tolerance for PSG5 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.82; 86.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSG5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG5 Gene

Disorders for PSG5 Gene

Relevant External Links for PSG5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG5 Gene

Publications for PSG5 Gene

  1. Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement. (PMID: 2735907) Khan W.N. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1989) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PMID: 7794280) Teglund S. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1995) 3 22 64
  4. Characterization of new members of the pregnancy-specific beta 1- glycoprotein family. (PMID: 1922019) Chan W.Y. … Tease L.A. (Mol. Cell. Biochem. 1991) 3 4 64
  5. A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene. (PMID: 2789512) Oikawa S. … Nakazato H. (Biochem. Biophys. Res. Commun. 1989) 3 4 64

Products for PSG5 Gene

Sources for PSG5 Gene

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