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PSG5 Gene

protein-coding   GIFtS: 50
GCID: GC19M043670

Pregnancy Specific Beta-1-Glycoprotein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pregnancy Specific Beta-1-Glycoprotein 51 2     PS-beta-G-52 3
Pregnancy-Specific Beta 1 Glycoprotein1 2     PSBG-52 3
Pregnancy-Specific Beta-1 Glycoprotein1 2     PSG2
Fetal Liver Non-Specific Cross-Reactive Antigen 32 3     Pregnancy-Specific Beta-1-Glycoprotein 52
Pregnancy-Specific Glycoprotein 52 3     Pregnancy-Specific Beta-1-Glycoprotein-52
FL-NCA-32 3     

External Ids:    HGNC: 95221   Entrez Gene: 56732   Ensembl: ENSG000002049417   OMIM: 1763945   UniProtKB: Q152383   

Export aliases for PSG5 gene to outside databases

Previous GC identifers: GC19M044320 GC19M044063 GC19M048105 GC19M048100 GC19M048287 GC19M048103 GC19M048366 GC19M047920 GC19M040101


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSG5 Gene:
The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the
placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA)
family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene
family, see PSG1 (MIM 176390).(supplied by OMIM, Oct 2009)

GeneCards Summary for PSG5 Gene:
PSG5 (pregnancy specific beta-1-glycoprotein 5) is a protein-coding gene. Diseases associated with PSG5 include leukemia, and endotheliitis. An important paralog of this gene is PSG9.

Gene Wiki entry for PSG5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSG5 gene promoter:
         c-Fos   AP-1   POU3F1   Pax-2   c-Jun   Pax-2a   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSG5 promoter sequence
   Search Chromatin IP Primers for PSG5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

PSG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSG5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M043670:  view genomic region     (about GC identifiers)

Start:
43,670,408 bp from pter      End:
43,690,688 bp from pter
Size:
20,281 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PSG5_HUMAN, Q15238 (See protein sequence)
Recommended Name: Pregnancy-specific beta-1-glycoprotein 5 precursor  
Size: 335 amino acids; 37713 Da
Developmental stage: PSBG are produced in high quantity during pregnancy
Secondary accessions: Q15239 Q96QJ1 Q9UQ75

Explore the universe of human proteins at neXtProt for PSG5: NX_Q15238

Explore proteomics data for PSG5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn104, Asn111, Asn175, Asn210
  • Modification sites at PhosphoSitePlus

  • See PSG5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123486.1  NP_002772.3  

    ENSEMBL proteins: 
     ENSP00000382334   ENSP00000386008   ENSP00000386053   ENSP00000471866   ENSP00000344413  
     ENSP00000385250  

    PSG5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PSG5

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    LSBio Antibodies in human, mouse, rat for PSG5

    PSG5 Assay Products:

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    Cloud-Clone Corp. CLIAs for PSG5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q15238

    ProtoNet protein and cluster: Q15238

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PSG5_HUMAN, Q15238
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    PSG5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for PSG5:
    pregnancy specific beta-1-glycoprotein 5,expressed by placental syncytiotrophoblasts,unknown
    function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    PSG5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PSG5:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSG5
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    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSG5_HUMAN, Q15238: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    PSG5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSG5
    Interactions:

        Search GeneGlobe Interaction Network for PSG5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for PSG5 (Q152381, 2, 3 ENSP000003444134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61854 I2D: score=3 
    TIE1P355901, ENSP000003615544EBI-4314891,EBI-2256865 STRING: ENSP00000361554
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007565female pregnancy TAS1690992

    PSG5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSG5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PSG5 gene (2 alternative transcripts): 
    NM_001130014.1  NM_002781.3  

    Unigene Cluster for PSG5:

    Pregnancy specific beta-1-glycoprotein 5
    Hs.654415  [show with all ESTs]
    Unigene Representative Sequence: NM_002781
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366175 ENST00000407356 ENST00000407568 ENST00000599812 ENST00000342951(uc002ovu.3 uc002ovx.3)
    ENST00000401942 ENST00000599214 ENST00000404580 ENST00000600817 ENST00000489220
    ENST00000401992
    miRNA
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    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PSG5
      QuantiTect SYBR Green Assays in human, mouse, rat PSG5
      QuantiFast Probe-based Assays in human, mouse, rat PSG5

    Additional mRNA sequence: 

    BC012607.1 L36607.1 M25384.1 M73713.1 

    Selected DOTS entries (see all 50):

    DT.87077474  DT.100799889  DT.91742662  DT.95375832  DT.121424672  DT.100784604  DT.91933184  DT.100759600 
    DT.121424834  DT.40123361  DT.91714482  DT.121424177  DT.121424560  DT.121424891  DT.92421520  DT.100784602 
    DT.91806732  DT.95305262  DT.100784597  DT.121424427  DT.121424748  DT.110610  DT.453453  DT.95375827 

    17 AceView cDNA sequences:

    CR606280 CR621678 D59036 CR609451 CR612136 CR625219 CR592362 CR607340 
    CR595886 CR605183 AL573460 NM_002781 BG009533 BF111910 BQ366854 CR592867 
    CR592773 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSG5 expression in normal human tissues (normalized intensities)      PSG5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PSG5 Expression
    About this image


    PSG5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Fibroblasts (Uncategorized)
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived mesenchymal stem cells
    PSG5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSG5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654415

    UniProtKB/Swiss-Prot: PSG5_HUMAN, Q15238
    Tissue specificity: Synthesized by syncytiotrophoblast of the placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for PSG5 (if available)
    TreeFam Gene Tree for PSG5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSG5 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
    PSG12  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  PSG22  
    CEACAM162  PSG42  PSG72  CEACAM32  
    Selected SIMAP similar genes for PSG5 using alignment to 4 protein entries:     PSG5_HUMAN (see all proteins) (see all similar genes):
    PSG    PSGII    DHFRP2    PSG11    PSG1    PSG8
    PSG2    PSG3    PSG6    PSG4    PSG7    SP1
    CEA    PSG9    CEACAM3    CEACAM4    CEACAM7    CEACAM8

    PSG5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSG5 (see all 881)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505874411,2
    C,Funtested143679421(+) GTTACG/AAACAG 4 /R /C mis12Minor allele frequency- A:0.00NA EU 5857
    rs1995392111,2
    --43671417(+) GAACT-/AAAAGA 2 -- int10--------
    rs1884012961,2
    C--43671547(+) GGAGTC/TTCTAT 2 -- int10--------
    rs1811860281,2
    --43671595(+) GCAAAA/TTAGGT 2 -- int10--------
    rs1866279001,2
    --43671597(+) AAAATA/TGGTTG 2 -- int10--------
    rs1914195351,2
    --43671610(+) TCTCAC/GCGAAC 2 -- int10--------
    rs1836955281,2
    --43671611(+) CTCACC/TGAACT 2 -- int10--------
    rs1481412131,2
    C--43671626(+) CAGATA/TTTTTA 2 -- int10--------
    rs1860527891,2
    --43671632(+) TTTTAC/GCTAAG 2 -- int10--------
    rs1429285011,2
    --43671640(+) AAGTGA/CGGAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for PSG5 (43670408 - 43690688 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PSG5 (see all 79):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718604CNV Deletion23290073
    esv2671788CNV Deletion23128226
    esv2671292CNV Deletion23128226
    esv2718603CNV Deletion23290073
    dgv565e201CNV Deletion23290073
    esv2657641CNV Deletion23128226
    dgv564e201CNV Deletion23290073
    esv2663048CNV Deletion23128226
    nsv471413CNV Duplication19718026
    dgv3898n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSG5
    DNA2.0 Custom Variant and Variant Library Synthesis for PSG5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176394    OMIM disorders: --

    2 diseases for PSG5:    About MalaCards
    leukemia    endotheliitis


    PSG5 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PSG5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 7690349 (1)


    Export disorders for PSG5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSG5 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with PSG5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement. (PubMed id 2735907)1, 2, 3 Khan W.N. and Hammarstroem S. (Biochem. Biophys. Res. Commun. 1989)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Characterization of new members of the pregnancy-specific beta 1- glycoprotein family. (PubMed id 1922019)1, 2 Chan W.Y.... Tease L.A. (Mol. Cell. Biochem. 1991)
    4. A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene. (PubMed id 2789512)1, 2 Oikawa S.... Nakazato H. (Biochem. Biophys. Res. Commun. 1989)
    5. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PubMed id 7794280)1, 9 Teglund S.... Hammarstroem S. (Biochem. Biophys. Res. Commun. 1995)
    6. Pregnancy-specific glycoproteins bind integrin I+IIbI^3 and inhibit the platelet-fibrinogen interaction. (PubMed id 23469002)1 Shanley D.K....Moore T. (PLoS ONE 2013)
    7. PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins. (PubMed id 23418492)1 Camolotto S.A....Panzetta-Dutari G.M. (PLoS ONE 2013)
    8. A secreted protein microarray platform for extracellular protein interaction discovery. (PubMed id 21982860)1 Ramani S.R....Gonzalez L.C. (Anal. Biochem. 2012)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5673 HGNC: 9522 AceView: PSG5 Ensembl:ENSG00000204941 euGenes: HUgn5673
    ECgene: PSG5 H-InvDB: PSG5

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSG5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSG5 gene:
    Search GeneIP for patents involving PSG5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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