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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PSG4 Gene

protein-coding   GIFtS: 46
GCID: GC19M043696

Pregnancy Specific Beta-1-Glycoprotein 4

Microbiology & Infectious Diseases Congress
  Search for PSG4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pregnancy Specific Beta-1-Glycoprotein 41 2     PS-beta-G-92 3
Pregnancy-Specific Beta-1-Glycoprotein 41 2     PSBG-42 3
Pregnancy-Specific Beta-1-Glycoprotein 92 3     PSBG-92 3
Pregnancy-Specific Glycoprotein 42 3     PSG92 3
Pregnancy-Specific Glycoprotein 92 3     Pregnancy-Specific Beta-1-Glycoprotein-42
PS-beta-G-42 3     CGM43

External Ids:    HGNC: 95211   Entrez Gene: 56722   Ensembl: ENSG000002431377   OMIM: 1763935   UniProtKB: Q008883   

Export aliases for PSG4 gene to outside databases

Previous GC identifers: GC19M044343 GC19M044088 GC19M048372 GC19M048388 GC19M048124 GC19M047918 GC19M040126


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PSG4 Gene:
The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts
by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and
analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA)
gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a
single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number
of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been
shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by
Teglund et al., 1994 (PubMed 7851896)). For additional general information about the PSG gene family, see PSG1
(MIM 176390).(supplied by OMIM, Oct 2009)

GeneCards Summary for PSG4 Gene: 
PSG4 (pregnancy specific beta-1-glycoprotein 4) is a protein-coding gene. An important paralog of this gene is PSG9.

Gene Wiki entry for PSG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSG4 gene promoter:
         c-Fos   AP-1   Pax-2   RelA   Pax-2a   NF-kappaB   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSG4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSG4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

PSG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSG4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M043696:  view genomic region     (about GC identifiers)

Start:
43,696,854 bp from pter      End:
43,711,451 bp from pter
Size:
14,598 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PSG4_HUMAN, Q00888 (See protein sequence)
Recommended Name: Pregnancy-specific beta-1-glycoprotein 4 precursor  
Size: 419 amino acids; 47113 Da
Subcellular location: Secreted (Potential)
Developmental stage: PSBG are produced in high quantity during pregnancy
Sequence caution: Sequence=AAA60208.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=M32625; Type=Erroneous gene model prediction;
Secondary accessions: Q13047 Q13048 Q15234 Q15240 Q9UQ76
Alternative splicing: 2 isoforms:  Q00888-1   Q00888-2   

Explore the universe of human proteins at neXtProt for PSG4: NX_Q00888

Explore proteomics data for PSG4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q00888

  • PSG4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PSG4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001263424.1  NP_002771.2  NP_998798.1  

    ENSEMBL proteins: 
     ENSP00000384770   ENSP00000244295   ENSP00000472423   ENSP00000471124   ENSP00000472885  
     ENSP00000470992   ENSP00000469547   ENSP00000472243   ENSP00000472818   ENSP00000388134  
     ENSP00000470073   ENSP00000387864  

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    Cloud-Clone Corp. Proteins for PSG4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--

    PSG4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q00888

    ProtoNet protein and cluster: Q00888

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PSG4_HUMAN, Q00888
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    PSG4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for PSG4:
    pregnancy specific beta-1-glycoprotein 4,expressed by placental syncytiotrophoblasts,unknown
    function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    PSG4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PSG4 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSG4

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response NAS--
    GO:0007565female pregnancy TAS7794280

    PSG4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PSG4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSG4

    2 Novoseek inferred chemical compound relationships for PSG4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreozymin 96.2 2 9183670 (1), 9645429 (1)
    progesterone 37.3 2 9183670 (1), 9645429 (1)

    Search CenterWatch for drugs/clinical trials and news about PSG4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PSG4 gene (3 alternative transcripts): 
    NM_001276495.1  NM_002780.4  NM_213633.2  

    Unigene Cluster for PSG4:

    Pregnancy specific beta-1-glycoprotein 4
    Hs.711363  [show with all ESTs]
    Unigene Representative Sequence: NM_002780
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000405312(uc002ovy.3 uc002ovz.3 uc002owb.3) ENST00000490769
    ENST00000244295 ENST00000597374 ENST00000597349 ENST00000596907 ENST00000599391
    ENST00000601041 ENST00000599746 ENST00000595949 ENST00000599371 ENST00000495316
    ENST00000596199 ENST00000451895 ENST00000600572 ENST00000597912 ENST00000433626

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PSG4
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSG4
    Clone
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    Additional mRNA sequence: 

    AF289606.1 AK075149.1 BC008405.1 BC013431.1 BC063127.1 M33665.1 M94891.1 U18468.1 
    U18469.1 X17097.1 

    24/103 DOTS entries (see all 103):

    DT.91781710  DT.91781740  DT.121424184  DT.402914  DT.100884399  DT.87005084  DT.95226495  DT.91695586 
    DT.121424255  DT.121424448  DT.40218659  DT.121424674  DT.121424827  DT.100772800  DT.100772793  DT.100772802 
    DT.121424538  DT.92055056  DT.100764243  DT.121424092  DT.91781729  DT.100764230  DT.100884377  DT.97863159 

    1 AceView cDNA sequence:

    BG620818 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSG4 expression in normal human tissues (normalized intensities)      PSG4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCACATTT
    PSG4 Expression
    About this image


    PSG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Fibroblast
             Detroit 551
             X-gene Foreskin Fibroblasts   
     
     Dermis (Uncategorized)    fully expand to see all 3 entries
             BH2 Dermal Fibroblasts   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Human Renal Mesangial Cells (HRMC)   
     
     Placenta (Extraembryonic Tissues)
             placenta   
     
     Mesoderm (Gastrulation Derivatives)
             PureStem Z11, Meso Progenitor

    See PSG4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSG4

    SOURCE GeneReport for Unigene cluster: Hs.711363
        SABiosciences Custom PCR Arrays for PSG4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSG4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for PSG4 (if available)
    TreeFam Gene Tree for PSG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSG4 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
    PSG12  PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  
    PSG22  CEACAM162  CEACAM32  PSG72  
    18/25 SIMAP similar genes for PSG4 using alignment to 13 protein entries:     PSG4_HUMAN (see all proteins) (see all similar genes):
    DHFRP2    PSGII    PSG    PSG3    PSG1    PSG11
    PSG6    PSG7    PSG5    PSG8    PSG2    CEA
    SP1    CEACAM3    PSG9    CEACAM7    CEACAM4    CEACAM8

    PSG4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/747 SNPs in PSG4 are shown (see all 747)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378613571,2
    --43696411(+) TGGGTC/GTTGGC 3 -- int10--------
    rs1418591481,2
    --43696587(+) CATGCC/G/TGGTAG 3 -- int10--------
    rs1438024921,2
    --43696604(+) CAGTGA/GACTGG 3 -- int10--------
    rs1481438281,2
    --43696606(+) GTGAAC/TTGGAA 3 -- int10--------
    rs1419367581,2
    C--43696620(+) GGTAAA/GGGATG 3 -- int10--------
    rs1506480761,2
    --43696621(+) GTAAGG/TGATGC 3 -- int10--------
    rs104208711,2
    C,F--43696632(+) TGGGTG/ATCCCA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1419892731,2
    C--43696644(+) GTTCTC/GTCTCA 3 -- int10--------
    rs1463047821,2
    C--43696664(+) CTGAAA/GATTTG 3 -- int10--------
    rs1918569961,2
    --43696681(+) GGGCTA/GGTACA 3 -- int10--------

    HapMap Linkage Disequilibrium report for PSG4 (43696854 - 43711451 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/74 variations for PSG4 (see all 74):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718604CNV Deletion23290073
    esv2659897CNV Deletion23128226
    dgv645e199CNV Deletion23128226
    esv2664621CNV Deletion23128226
    esv2671292CNV Deletion23128226
    esv2718603CNV Deletion23290073
    esv2658764CNV Deletion23128226
    nsv820547CNV Deletion20802225
    nsv435702CNV Deletion17901297
    dgv565e201CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PSG4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PSG4 for disorders           About MalaCards
    OMIM gene information: 176393    OMIM disorders: --


    PSG4 for disorders           About GeneDecksing


    Export disorders for PSG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSG4 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with PSG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. (PubMed id 2783133)1, 2, 3 Zimmermann W.A.... Thompson J.A. (1989)
    2. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PubMed id 7794280)1, 2, 9 Teglund S.... Hammarstroem S. (1995)
    3. Characterization of new members of the pregnancy-specific beta 1- glycoprotein family. (PubMed id 1922019)1, 2 Chan W.Y.... Tease L.A. (1991)
    4. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PubMed id 1690992)1, 2 Thompson J.... Hardman N. (1990)
    5. Characterization of two new members of the pregnancy-specific beta 1- glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit. (PubMed id 2271648)1, 2 Barnett T.R.... Elting J.J. (1990)
    6. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PubMed id 2346490)1, 2 (1990)
    7. Characterization of cDNA encoding human pregnancy-specific beta 1- glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen. (PubMed id 3180995)1, 2 Chan W.-Y.... Shupert W.L. (1988)
    8. A single human cell expresses all messenger ribonucleic acids: the arrow of time in a cell. (PubMed id 9645429)1, 9 Kimoto Y. (1998)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5672 HGNC: 9521 AceView: PSG4 Ensembl:ENSG00000243137 euGenes: HUgn5672
    ECgene: PSG4 H-InvDB: PSG4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSG4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSG4 gene:
    Search GeneIP for patents involving PSG4

    GeneCards and IP:
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