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Aliases for PSG3 Gene

Aliases for PSG3 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 3 2 3
  • Pregnancy-Specific Glycoprotein 3 3 4
  • Carcinoembryonic Antigen SG5 3 4
  • PS-Beta-G-3 3 4
  • PSBG-3 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 3 3

External Ids for PSG3 Gene

Previous GeneCards Identifiers for PSG3 Gene

  • GC19M043874
  • GC19M043617
  • GC19M047901
  • GC19M047917
  • GC19M043225
  • GC19M039655

Summaries for PSG3 Gene

Entrez Gene Summary for PSG3 Gene

  • The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG3 Gene

PSG3 (Pregnancy Specific Beta-1-Glycoprotein 3) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

Gene Wiki entry for PSG3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG3 Gene

Genomics for PSG3 Gene

Regulatory Elements for PSG3 Gene

Genomic Location for PSG3 Gene

Start:
42,721,638 bp from pter
End:
42,740,569 bp from pter
Size:
18,932 bases
Orientation:
Minus strand

Genomic View for PSG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG3 Gene

Proteins for PSG3 Gene

  • Protein details for PSG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16557-PSG3_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 3
    Protein Accession:
    Q16557
    Secondary Accessions:
    • Q08265
    • Q9BRW2
    • Q9UPL4
    • Q9UQ77

    Protein attributes for PSG3 Gene

    Size:
    428 amino acids
    Molecular mass:
    47945 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSG3 Gene

Proteomics data for PSG3 Gene at MOPED

Post-translational modifications for PSG3 Gene

  • Glycosylation at Asn104, Asn111, Asn268, and Asn303
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG3 Gene

Antibody Products

No data available for DME Specific Peptides for PSG3 Gene

Domains for PSG3 Gene

Gene Families for PSG3 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for PSG3 Gene

Suggested Antigen Peptide Sequences for PSG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16557

UniProtKB/Swiss-Prot:

PSG3_HUMAN :
  • Q16557
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG3: view

Function for PSG3 Gene

Molecular function for PSG3 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 3,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Gene Ontology (GO) - Molecular Function for PSG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PSG3: view

Animal Model Products

CRISPR Products

miRNA for PSG3 Gene

miRTarBase miRNAs that target PSG3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PSG3 Gene

Localization for PSG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSG3 Gene COMPARTMENTS Subcellular localization image for PSG3 gene
Compartment Confidence
extracellular 5
mitochondrion 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PSG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSG3: view

Pathways for PSG3 Gene

SuperPathways for PSG3 Gene

No Data Available

Interacting Proteins for PSG3 Gene

Gene Ontology (GO) - Biological Process for PSG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 2341148
GO:0007565 female pregnancy TAS 2341148
genes like me logo Genes that share ontologies with PSG3: view

No data available for Pathways by source for PSG3 Gene

Transcripts for PSG3 Gene

Unigene Clusters for PSG3 Gene

Pregnancy specific beta-1-glycoprotein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSG3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSG3 Gene

No ASD Table

Relevant External Links for PSG3 Gene

GeneLoc Exon Structure for
PSG3
ECgene alternative splicing isoforms for
PSG3

Expression for PSG3 Gene

mRNA expression in normal human tissues for PSG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG3 Gene

This gene is overexpressed in Testis (31.4).

Protein differential expression in normal tissues for PSG3 Gene

This gene is overexpressed in Lung (42.8) and Placenta (26.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PSG3 Gene

SOURCE GeneReport for Unigene cluster for PSG3 Gene Hs.654413

genes like me logo Genes that share expressions with PSG3: view

Expression partners for PSG3 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PSG3 Gene

Orthologs for PSG3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSG3 35
  • 98.47 (n)
  • 97.34 (a)
PSG3 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 26 (a)
ManyToMany
CEACAM1 36
  • 34 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg27 36
  • 19 (a)
ManyToMany
Species with no ortholog for PSG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG3 Gene

ENSEMBL:
Gene Tree for PSG3 (if available)
TreeFam:
Gene Tree for PSG3 (if available)

Paralogs for PSG3 Gene

genes like me logo Genes that share paralogs with PSG3: view

Variants for PSG3 Gene

Sequence variations from dbSNP and Humsavar for PSG3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12268 -- 42,721,871(-) TATTG(G/T)ACTAA utr-variant-3-prime
rs1058704 -- 42,730,016(-) TTAAA(A/C)CCCAG missense, reference
rs1063008 -- 42,728,954(-) CTTCT(C/G)CTTGT intron-variant
rs1064504 -- 42,721,760(-) gtaaa(C/G)tatac utr-variant-3-prime
rs1065179 -- 42,729,346(-) CCTTC(A/G)TTCAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PSG3 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV Deletion 17116639
dgv15e196 CNV Deletion 17116639
dgv1086e1 CNV Complex 17122850
dgv1087e1 CNV Complex 17122850
dgv1088e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
nsv510768 CNV Loss 20534489
nsv833835 CNV Gain 17160897
nsv428364 CNV Gain+Loss 18775914
nsv482222 CNV Gain 20164927
nsv911809 CNV Gain 21882294
dgv3890n71 CNV Gain 21882294
dgv1089e1 CNV Complex 17122850
dgv141e55 CNV Loss 17911159

Relevant External Links for PSG3 Gene

HapMap Linkage Disequilibrium report
PSG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG3 Gene

Disorders for PSG3 Gene

No disorders were found for PSG3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PSG3 Gene

Publications for PSG3 Gene

  1. Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1 glycoprotein gene family. (PMID: 2341148) Streydio C. … Vassart G. (Genomics 1990) 2 3 4
  2. Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning. (PMID: 2350345) Zoubir F. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1990) 3 4
  3. Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1-glycoprotein gene family. (PMID: 2387594) Streydio C. … Vassart G. (Genomics 1990) 3 4
  4. Molecular cloning of a cDNA for human pregnancy-specific beta 1- glycoprotein: homology with human carcinoembryonic antigen and related proteins. (PMID: 3265688) Rooney B.C. … Hardman N. (Gene 1988) 3 4
  5. Pregnancy specific beta 1-glycoprotein in human intestine. (PMID: 8487756) Shupert W.L. … Chan W.Y. (Mol. Cell. Biochem. 1993) 3 4

Products for PSG3 Gene

Sources for PSG3 Gene

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