PSG3 Gene
protein-coding GIFtS: 46
GCID: GC19M043225
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pregnancy specific beta-1-glycoprotein 3
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Aliases
for PSG3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pregnancy Specific Beta-1-Glycoprotein 31 2 | | Carcinoembryonic Antigen SG52 3 | | Pregnancy-Specific Glycoprotein 32 3 | | PS-Beta-G-31 | | PSBG-32 3 | | Pregnancy-Specific Beta-1-Glycoprotein 32 |
Export aliases for PSG3 gene to outside databasesPrevious GC identifers: GC19M043874 GC19M043617 GC19M047901 GC19M047917 GC19M039655 |
Summaries
for PSG3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PSG3:
The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts byplacental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis ofseveral PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, whichbelongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, withstructural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulinconstant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as anadhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 (PubMed7851896)). For additional general information about the PSG gene family, see PSG1 (MIM 176390).(supplied by OMIM, Oct2009)
Gene Wiki entry for PSG3
|
Genomic Views
for PSG3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PSG3 gene promoter:
NCX/Ncx p300 POU3F1 RelA NF-kappaB RORalpha2 AREB6 c-Myb NF-kappaB1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PSG3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSG3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2PSG3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M043225: view genomic region
(about GC identifiers)
Start:
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43,225,794 bp from pter |
End:
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43,244,721 bp from pter |
Size:
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18,928 bases |
Orientation:
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minus strand |
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Proteins
for PSG3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PSG3_HUMAN, Q16557 (See
protein sequence)Recommended Name: Pregnancy-specific beta-1-glycoprotein 3 precursor Size: 428 amino acids; 47945 Da
Subcellular location: Secreted (Potential)
Developmental stage: PSBG are produced in high quantity during pregnancy
Secondary accessions: Q08265 Q9BRW2 Q9UPL4 Q9UQ77Explore the universe of human proteins at neXtProt for PSG3: NX_Q16557
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16557
PSG3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066296.2
ENSEMBL proteins: ENSP00000332215
Human Recombinant Protein Products for PSG3:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
NAS | -- |
PSG3 for ontologies About GeneDecksing
PSG3 Antibody Products:
Assay Products for PSG3: |
Protein
Domains /
Families
for PSG3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PSG3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q16557ProtoNet protein and cluster: Q16557 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: PSG3_HUMAN, Q16557Similarity: Belongs to the immunoglobulin superfamily. CEA familySimilarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for PSG3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
Genatlas biochemistry entry for PSG3:pregnancy specific beta-1-glycoprotein 3,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonicantigen (CEA family),immunoglobulin superfamily
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSG3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSG3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PSG3 (NM_021016) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PSG3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSG3 |
|
Pathways & Interactions
for PSG3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSG3
5/6 Interacting proteins for PSG3 (Q165572, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
PSG3 for ontologies About GeneDecksing
|
Drugs & Compounds
for PSG3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PSG3
Search CenterWatch for drugs/clinical trials and news about PSG3
|
Transcripts
for PSG3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PSG3 gene: NM_021016.3 Unigene Cluster for PSG3: Pregnancy specific beta-1-glycoprotein 3 Hs.654413 [show with all ESTs]Unigene Representative Sequence: S594942 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000327495(uc002oue.3 uc002ouf.3) ENST00000490592
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSG3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSG3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PSG3 (NM_021016) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PSG3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSG3 |
Additional cDNA sequence: AB019570.1 BC005924.1 M27907.1 M30628.1 M34420.1 M37399.1 M93061.1 S59493.1 S59494.1 24/83 DOTS entries (see all 83): DT.40123361 DT.91726544 DT.100884371 DT.91806732 DT.100643170 DT.121424914 DT.92415484 DT.121424082 DT.100884334 DT.100884321 DT.100884373 DT.121424297 DT.100729148 DT.91781740 DT.91641063 DT.91933184 DT.100884375 DT.100884409 DT.102844189 DT.91896418 DT.121644100 DT.121424052 DT.92046153 DT.121424654 24/28 AceView cDNA sequences (see all 28): CR605585 CR623537 CR613711 CR594229 T29368 CR596325 H62033 CR625118 S59494 BE767902 BC005924 M30628 M34420 M37399 M27907 NM_021016 AA368375 BG005643 BG621332 BX097191 AA367500 BG434286 CR603900 NM_002785
GeneLoc Exon Structure
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Expression
for PSG3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PSG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTCAAGA
About this image
See PSG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSG3
SOURCE GeneReport for Unigene cluster: Hs.654413
SABiosciences Custom PCR Arrays for PSG3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSG3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PSG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSG3 |
Orthologs
for PSG3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PSG3 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for PSG3 (if available)
TreeFam Gene Tree for PSG3 (if available) |
Paralogs
for PSG3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PSG3 gene
- PSG92 PSG82 CEACAM52 CEACAM42 PSG112 CEACAM72 CEACAM212 PSG12
- PSG52 PSG62 CEACAM12 CEACAM82 CEACAM62 PSG22 CEACAM182 CEACAM162
- PSG42 CEACAM32
18/22 SIMAP similar genes for PSG3 using alignment to 3 protein entries: PSG3_HUMAN (see all proteins)
(see all similar genes):DHFRP2 PSG7 PSG PSGII PSG4 SP1
PSG1 PSG6 PSG8 PSG5 PSG11 CEA
PSG9 CEACAM7 CEACAM3 PSG2 CEACAM21 DKFZp781M2392
PSG3 for paralogs About GeneDecksing
|
Genomic Variants
for PSG3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PSG3 (43225794 - 43244721 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for PSG3
13 CNVs: 34532 5445 8872 5446 34649 78206 30908 4082 3192 89254 5101 9307 5444 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSG3 |
|
Disorders
/ Diseases
for PSG3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 PSG3 for disorders About MalaCards
PSG3 for disorders About GeneDecksing
OMIM gene information: 176392
OMIM disorders: --
Export disorders for PSG3 gene to outside databases
|
Publications
for PSG3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PSG3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with PSG3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1 glycoprotein gene family. (PubMed id 2341148)1, 2, 3 Streydio C.... Vassart G. (1990)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Pregnancy specific beta 1-glycoprotein in human intestine. (PubMed id 8487756)1, 2 Shupert W.L. and Chan W.Y. (1993)
- Expression of the pregnancy-specific beta 1-glycoprotein genes in human testis. (PubMed id 2302228)1, 2 Borjigin J.... Chan W.-Y. (1990)
- Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1-glycoprotein gene family. (PubMed id 2387594)1, 2 Streydio C....Vassart G. (1990)
- Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning. (PubMed id 2350345)1, 2 Zoubir F.... Hammarstroem S. (1990)
- Molecular cloning of a cDNA for human pregnancy-specific beta 1- glycoprotein: homology with human carcinoembryonic antigen and related proteins. (PubMed id 3265688)1, 2 Rooney B.C.... Hardman N. (1988)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
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External Searches for PSG3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PSG3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PSG3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PSG3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PSG3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for PSG3 gene:
Search GeneIP for patents involving PSG3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PSG3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PSG3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSG3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSG3 | | | OriGene Protein Over-expression Lysate for PSG3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PSG3 | | OriGene 3'-UTR Clone for PSG3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSG3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSG3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PSG3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | PSG3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for PSG3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSG3 |
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