Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSG3 Gene

Aliases for PSG3 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 3 2 3 5
  • Pregnancy-Specific Glycoprotein 3 3 4
  • Carcinoembryonic Antigen SG5 3 4
  • PS-Beta-G-3 3 4
  • PSBG-3 3 4

External Ids for PSG3 Gene

Previous GeneCards Identifiers for PSG3 Gene

  • GC19M043874
  • GC19M043617
  • GC19M047901
  • GC19M047917
  • GC19M043225
  • GC19M039655

Summaries for PSG3 Gene

Entrez Gene Summary for PSG3 Gene

  • The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG3 Gene

PSG3 (Pregnancy Specific Beta-1-Glycoprotein 3) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

Gene Wiki entry for PSG3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG3 Gene

Genomics for PSG3 Gene

Regulatory Elements for PSG3 Gene

Enhancers for PSG3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG3 Gene

42,721,638 bp from pter
42,740,569 bp from pter
18,932 bases
Minus strand

Genomic View for PSG3 Gene

Genes around PSG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG3 Gene

Proteins for PSG3 Gene

  • Protein details for PSG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 3
    Protein Accession:
    Secondary Accessions:
    • Q08265
    • Q9BRW2
    • Q9UPL4
    • Q9UQ77

    Protein attributes for PSG3 Gene

    428 amino acids
    Molecular mass:
    47945 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSG3 Gene

Proteomics data for PSG3 Gene at MOPED

Post-translational modifications for PSG3 Gene

  • Glycosylation at Asn 104, Asn 111, Asn 268, and Asn 303
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG3 Gene

No data available for DME Specific Peptides for PSG3 Gene

Domains & Families for PSG3 Gene

Protein Domains for PSG3 Gene

Suggested Antigen Peptide Sequences for PSG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG3: view

Function for PSG3 Gene

Molecular function for PSG3 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 3,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily
genes like me logo Genes that share phenotypes with PSG3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG3 Gene

Localization for PSG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG3 Gene


Subcellular locations from

Jensen Localization Image for PSG3 Gene COMPARTMENTS Subcellular localization image for PSG3 gene
Compartment Confidence
extracellular 4
mitochondrion 2
cytosol 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PSG3 Gene

Pathways & Interactions for PSG3 Gene

SuperPathways for PSG3 Gene

No Data Available

Interacting Proteins for PSG3 Gene

Gene Ontology (GO) - Biological Process for PSG3 Gene


No data available for Pathways by source and SIGNOR curated interactions for PSG3 Gene

Drugs & Compounds for PSG3 Gene

No Compound Related Data Available

Transcripts for PSG3 Gene

Unigene Clusters for PSG3 Gene

Pregnancy specific beta-1-glycoprotein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSG3 Gene

No ASD Table

Relevant External Links for PSG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSG3 Gene

mRNA expression in normal human tissues for PSG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG3 Gene

This gene is overexpressed in Testis (x31.4).

Protein differential expression in normal tissues from HIPED for PSG3 Gene

This gene is overexpressed in Lung (42.8) and Placenta (26.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG3 Gene

SOURCE GeneReport for Unigene cluster for PSG3 Gene Hs.654413

genes like me logo Genes that share expression patterns with PSG3: view

Protein tissue co-expression partners for PSG3 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PSG3 Gene

Orthologs for PSG3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSG3 35
  • 98.47 (n)
  • 97.34 (a)
PSG3 36
  • 97 (a)
(Bos Taurus)
Mammalia -- 36
  • 26 (a)
  • 34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
(Mus musculus)
Mammalia Psg27 36
  • 19 (a)
Species with no ortholog for PSG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG3 Gene

Gene Tree for PSG3 (if available)
Gene Tree for PSG3 (if available)

Paralogs for PSG3 Gene

genes like me logo Genes that share paralogs with PSG3: view

Variants for PSG3 Gene

Sequence variations from dbSNP and Humsavar for PSG3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12185496 -, - 42,739,065(+) TAGGC(A/G)AGTTC reference, missense
rs11559136 - 42,739,086(-) AGCAT(C/T)ACTTT reference, missense
rs16976174 - 42,732,900(-) CAAAA(A/C/T)CAACA reference, missense
rs17173152 - 42,732,896(+) GTCCT(C/G/T)TTGTT reference, missense
rs28698193 - 42,729,897(+) TTTCA(A/T)TGGGT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PSG3 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV Deletion 17116639
dgv15e196 CNV Deletion 17116639
dgv1086e1 CNV Complex 17122850
dgv1087e1 CNV Complex 17122850
dgv1088e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
nsv510768 CNV Loss 20534489
nsv833835 CNV Gain 17160897
nsv428364 CNV Gain+Loss 18775914
nsv482222 CNV Gain 20164927
nsv911809 CNV Gain 21882294
dgv3890n71 CNV Gain 21882294
dgv1089e1 CNV Complex 17122850
dgv141e55 CNV Loss 17911159

Variation tolerance for PSG3 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 60.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSG3 Gene

Disorders for PSG3 Gene

Relevant External Links for PSG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG3 Gene

Publications for PSG3 Gene

  1. Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1 glycoprotein gene family. (PMID: 2341148) Streydio C. … Vassart G. (Genomics 1990) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3

Products for PSG3 Gene

Sources for PSG3 Gene