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PSG2 Gene

protein-coding   GIFtS: 49
GCID: GC19M043568

Pregnancy Specific Beta-1-Glycoprotein 2


(Previous symbol: PSBG2)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Pregnancy Specific Beta-1-Glycoprotein 21 2     PS-beta-G-22 3
PSBG21 2 3 5     PSBG-22 3
Carcinoembryonic Antigen SG81 2     Pregnancy-Specific Beta-1 Glycoprotein1
Pregnancy-Specific Beta-1-Glycoprotein 71 2     CEA2
Pregnancy-Specific Beta-1 Glycoprotein E2 3     PSG12
Pregnancy-Specific Glycoprotein 22 3     Pregnancy-Specific Beta-1-Glycoprotein 22
PS-beta-E2 3     Pregnancy-Specific Beta-1-Glycoprotein-22

External Ids:    HGNC: 95191   Entrez Gene: 56702   Ensembl: ENSG000002422217   OMIM: 1763915   UniProtKB: P114653   
ORGUL members:         

Export aliases for PSG2 gene to outside databases

Previous GC identifers: GC19M044217 GC19M043763 GC19M048083 GC19M048099 GC19M048260 GC19M048122 GC19M040000


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSG2 Gene:
The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts
by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and
analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA)
gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a
single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number
of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been
shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by
Teglund et al., 1994 (PubMed 7851896)). For additional general information about the PSG gene family, see PSG1
(MIM 176390).(supplied by OMIM, Oct 2009)

GeneCards Summary for PSG2 Gene:
PSG2 (pregnancy specific beta-1-glycoprotein 2) is a protein-coding gene. Diseases associated with PSG2 include apocrine adenoma, and secretory meningioma. An important paralog of this gene is PSG9.

Gene Wiki entry for PSG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PSG2 gene promoter:
         Tal-1   POU3F1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   LCR-F1   E47   Meis-1b   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSG2 promoter sequence
   Search Chromatin IP Primers for PSG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.1-q13.2

PSG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSG2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M043568:  view genomic region     (about GC identifiers)

Start:
43,568,362 bp from pter      End:
43,587,197 bp from pter
Size:
18,836 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PSG2_HUMAN, P11465 (See protein sequence)
Recommended Name: Pregnancy-specific beta-1-glycoprotein 2 precursor  
Size: 335 amino acids; 37216 Da
Secondary accessions: Q8TCD9 Q9UEA4 Q9UQ78

Explore the universe of human proteins at neXtProt for PSG2: NX_P11465

Explore proteomics data for PSG2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn61, Asn104, Asn111, Asn199
  • Modification sites at PhosphoSitePlus

  • See PSG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112536.2  
    ENSEMBL proteins: 
     ENSP00000385706   ENSP00000332984  

    PSG2 Human Recombinant Protein Products:

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    Novus Biologicals PSG2 Lysates
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    Cloud-Clone Corp. Proteins for PSG2

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    Abcam antibodies for PSG2 (P11465, P11465 )
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    Search ThermoFisher Antibodies for PSG2
    LSBio Antibodies in human, mouse, rat for PSG2

    PSG2 Assay Products:

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    Cloud-Clone Corp. CLIAs for PSG2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P11465

    ProtoNet protein and cluster: P11465

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PSG2_HUMAN, P11465
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    PSG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for PSG2:
    pregnancy specific beta-1-glycoprotein 2,expressed by placental syncytiotrophoblasts,unknown
    function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    PSG2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSG2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PSG2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSG2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSG2

    miRNA
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    miRTarBase miRNAs that target PSG2:
    hsa-mir-148b-3p (MIRT019257)

    Block miRNA regulation of human, mouse, rat PSG2 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidPSG2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PSG2

    Gene Editing
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    Sino Biological Human cDNA Clone for PSG2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSG2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSG2_HUMAN, P11465: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    PSG2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSG2
    Interactions:

        Search GeneGlobe Interaction Network for PSG2

    1 Interacting protein for PSG2 (P114652, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134852, 3MINT-61981 I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007565female pregnancy NAS3260773
    GO:0016477cell migration NAS3260773

    PSG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSG2

    Selected Novoseek inferred chemical compound relationships for PSG2 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-fluorocytosine 41.4 11 11507067 (1), 16721685 (1), 9331089 (1), 10341879 (1) (see all 6)
    marimastat 38.4 5 10027321 (2), 10487607 (2)
    sialic acid 38.1 30 1669462 (4), 2096995 (3), 1567173 (3), 16010093 (2) (see all 11)
    b 723 36.7 2 1709062 (1), 9829382 (1)
    sodium iodide 30.3 2 17931047 (1), 17133484 (1)
    5fluorouracil 25.4 11 9796980 (5), 14998548 (1), 1830034 (1), 8797658 (1) (see all 5)
    leucovorin 24 3 9796980 (2), 20440858 (1)
    cytosine 23.1 6 8898638 (2), 16721685 (1), 9331089 (1), 7578407 (1) (see all 5)
    paraffin 21 5 17614779 (1), 16405409 (1), 7722085 (1), 10360677 (1)
    perchloric acid 18.2 2 1851320 (1), 1709822 (1)



    PSG2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PSG2 gene: 
    NM_031246.3  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406487(uc002ovr.3) ENST00000329509 ENST00000593482 ENST00000491995

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat PSG2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PSG2
    SwitchGear 3'UTR luciferase reporter plasmidPSG2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PSG2
    Predesigned siRNA for gene silencing in human, mouse, rat PSG2
    Clone
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    OriGene clones in human, mouse for PSG2 (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PSG2 (NM_031246)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSG2
    Primer
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    OriGene qPCR primer pairs and template standards for PSG2
    OriGene qSTAR qPCR primer pairs in human, mouse for PSG2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat PSG2
      QuantiTect SYBR Green Assays in human, mouse, rat PSG2
      QuantiFast Probe-based Assays in human, mouse, rat PSG2

    3 AceView cDNA sequences:

    BE929360 BF086244 CR623062 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSG2 expression in normal human tissues (normalized intensities)      PSG2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PSG2 Expression
    About this image


    PSG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Placenta (Extraembryonic Tissues)
    PSG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSG2 Protein Expression
        Custom PCR Arrays for PSG2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for PSG2 (if available)
    TreeFam Gene Tree for PSG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSG2 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
    PSG12  PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  
    CEACAM162  PSG42  PSG72  CEACAM32  
    Selected SIMAP similar genes for PSG2 using alignment to 1 protein entry:     PSG2_HUMAN(see all similar genes):
    DHFRP2    PSG    PSG11    PSG1    PSG5    PSGII
    CEA    PSG4    PSG6    PSG8    CEACAM8    PSG9
    CEACAM6    SP1    CEACAM3    CEACAM1    CEACAM7    PSG3

    PSG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSG2 (see all 895)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453831831,2
    C--43567890(+) AAGAAC/TTCAGG 1 -- ds50010--------
    rs1464587811,2
    --43567961(+) TGGTAA/GCAGGT 1 -- ds50010--------
    rs584128161,2
    C--43568001(+) TTTCTC/GTCTAT 1 -- ds50010--------
    rs1826707801,2
    C--43568061(+) GCAAAA/TTTGGT 1 -- ds50010--------
    rs1853491941,2
    C--43568063(+) AAATTA/TGGTTG 1 -- ds50010--------
    rs1901572151,2
    --43568077(+) CTCACC/GGAACT 1 -- ds50010--------
    rs1827286571,2
    --43568125(+) ATGGAA/CTGTAG 1 -- ds50010--------
    rs104130101,2
    C,F,H--43568183(+) cagatT/Gaaact 1 -- ds50012Minor allele frequency- G:0.33NA 6
    rs1873617511,2
    --43568226(+) CAAGGC/TCCACT 1 -- ds50010--------
    rs124598821,2
    C,F,H--43568269(+) tctatG/Atatat 1 -- ds50013Minor allele frequency- A:0.38NA 8

    HapMap Linkage Disequilibrium report for PSG2 (43568362 - 43587197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PSG2 (see all 85):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv15e196CNV Deletion17116639
    esv2422471CNV Deletion17116639
    esv2718603CNV Deletion23290073
    dgv565e201CNV Deletion23290073
    esv2657641CNV Deletion23128226
    esv2718602CNV Deletion23290073
    esv2663048CNV Deletion23128226
    dgv564e201CNV Deletion23290073
    esv2718595CNV Deletion23290073
    dgv3898n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): PSG2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSG2
    DNA2.0 Custom Variant and Variant Library Synthesis for PSG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176391    OMIM disorders: --

    Selected diseases for PSG2 (see all 85):    About MalaCards
    apocrine adenoma    secretory meningioma    cardiac tamponade    pleurisy
    pseudomyxoma peritonei    pericardial effusion    gallbladder cancer    adenomatoid tumor
    cholelithiasis    mucinous cystadenocarcinoma    pericarditis    breast disease
    peripheral primitive neuroectodermal tumor    bronchogenic carcinoma    vitamin b12 deficiency    iron deficiency anemia
    megaloblastic anemia    deficiency anemia    paraganglioma    obstructive jaundice


    PSG2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PSG2 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 73.4 540 9212243 (8), 17486473 (6), 1961181 (5), 8104371 (5) (see all 99)
    colorectal cancer 70.6 157 16122885 (11), 8223061 (4), 11957811 (4), 9100477 (4) (see all 67)
    thyroid carcinoma medullary 65.7 6 17372055 (3), 8580565 (1), 11326706 (1), 15251732 (1)
    cancer 63.9 199 10195726 (6), 19322585 (5), 10668938 (4), 12661896 (4) (see all 99)
    colon cancer 63 46 19140877 (3), 19757443 (3), 8674374 (3), 2337875 (3) (see all 28)
    colon carcinoma 60.5 20 11062726 (5), 10873577 (3), 2067130 (2), 1815506 (1) (see all 9)
    gastric cancer 60.4 62 7561233 (3), 9070891 (3), 19661375 (3), 8640823 (3) (see all 32)
    pleural effusion malignant 59.6 12 15804072 (5), 8983362 (2), 8260229 (1), 17724538 (1) (see all 7)
    colorectal carcinoma 57.8 22 2168182 (2), 1311626 (2), 1726506 (1), 7850776 (1) (see all 17)
    secretory meningioma 56.8 1 1984492 (1)


    Export disorders for PSG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSG2 gene, integrated from 10 sources (see all 607):
    (articles sorted by number of sources associating them with PSG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PubMed id 2377620)1, 3 Leslie K.K.... Chou J.Y. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    4. The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family. (PubMed id 3260773)1, 2 Streydio C.... Vassart G. (Biochem. Biophys. Res. Commun. 1988)
    5. The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family. (PubMed id 7851896)1, 9 Teglund S....HammarstrAPm S. (Genomics 1994)
    6. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PubMed id 1690992)1, 9 Thompson J.... Hardman N. (Biochem. Biophys. Res. Commun. 1990)
    7. CEA and CA-19.9 serum tumor markers as prognostic factors in patients with locally advanced (unresectable) or metastatic pancreatic adenocarcinoma: a retrospective analysis. (PubMed id 20071292)1 Tsavaris N....Papalambros A. (J Chemother 2009)
    8. Identification and characterization of endonuclein binding proteins: evidence of modulatory effects on signal transduction and chaperone activity. (PubMed id 20028516)1 Ludvigsen M....HonorAc B. (BMC Biochem. 2009)
    9. Efficient induction of T-cell responses to carcinoembryonic antigen by a heterologous prime-boost regimen using DNA and adenovirus vectors carrying a codon usage optimized cDNA. (PubMed id 15906358)1 Mennuni C....La Monica N. (Int. J. Cancer 2005)
    10. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (Genome Res. 2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5670 HGNC: 9519 AceView: PSG11andPSG2 Ensembl:ENSG00000242221 euGenes: HUgn5670
    ECgene: PSG2 H-InvDB: PSG2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSG2 gene:
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