Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PSG2 Gene

Aliases for PSG2 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 2 2 3 5
  • Pregnancy-Specific Beta-1-Glycoprotein 7 2 3
  • Pregnancy-Specific Beta-1 Glycoprotein E 3 4
  • Pregnancy-Specific Glycoprotein 2 3 4
  • Carcinoembryonic Antigen SG8 2 3
  • PS-Beta-G-2 3 4
  • PS-Beta-E 3 4
  • PSBG-2 3 4
  • PSBG2 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein-2 3
  • Pregnancy-Specific Beta-1 Glycoprotein 2
  • PSG1 3
  • CEA 3

External Ids for PSG2 Gene

Previous HGNC Symbols for PSG2 Gene

  • PSBG2

Previous GeneCards Identifiers for PSG2 Gene

  • GC19M044217
  • GC19M043763
  • GC19M048083
  • GC19M048099
  • GC19M048260
  • GC19M048122
  • GC19M043568
  • GC19M040000

Summaries for PSG2 Gene

Entrez Gene Summary for PSG2 Gene

  • The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG2 Gene

PSG2 (Pregnancy Specific Beta-1-Glycoprotein 2) is a Protein Coding gene. Diseases associated with PSG2 include Colorectal Cancer and Pancreatic Cancer. An important paralog of this gene is CEACAM8.

Gene Wiki entry for PSG2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG2 Gene

Genomics for PSG2 Gene

Regulatory Elements for PSG2 Gene

Enhancers for PSG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG2 Gene

Chromosome:
19
Start:
43,064,210 bp from pter
End:
43,083,045 bp from pter
Size:
18,836 bases
Orientation:
Minus strand

Genomic View for PSG2 Gene

Genes around PSG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG2 Gene

Proteins for PSG2 Gene

  • Protein details for PSG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11465-PSG2_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 2
    Protein Accession:
    P11465
    Secondary Accessions:
    • Q8TCD9
    • Q9UEA4
    • Q9UQ78

    Protein attributes for PSG2 Gene

    Size:
    335 amino acids
    Molecular mass:
    37216 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSG2 Gene

Proteomics data for PSG2 Gene at MOPED

Post-translational modifications for PSG2 Gene

  • Glycosylation at Asn 61, Asn 104, Asn 111, and Asn 199
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSG2 Gene

Domains & Families for PSG2 Gene

Protein Domains for PSG2 Gene

Suggested Antigen Peptide Sequences for PSG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11465

UniProtKB/Swiss-Prot:

PSG2_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG2: view

Function for PSG2 Gene

Molecular function for PSG2 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 2,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Phenotypes for PSG2 Gene

genes like me logo Genes that share phenotypes with PSG2: view

Animal Model Products

CRISPR Products

miRNA for PSG2 Gene

miRTarBase miRNAs that target PSG2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG2 Gene

Localization for PSG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSG2 Gene COMPARTMENTS Subcellular localization image for PSG2 gene
Compartment Confidence
extracellular 4
chloroplast 1
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSG2: view

Pathways & Interactions for PSG2 Gene

SuperPathways for PSG2 Gene

No Data Available

Interacting Proteins for PSG2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000385706%0d%0a9606.ENSP00000387365%0d%0a
Selected Interacting proteins: P11465-PSG2_HUMAN ENSP00000385706 for PSG2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for PSG2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PSG2 Gene

Drugs & Compounds for PSG2 Gene

(12) Drugs for PSG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(23) Additional Compounds for PSG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSG2: view

Transcripts for PSG2 Gene

mRNA/cDNA for PSG2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSG2 Gene

Pregnancy specific beta-1-glycoprotein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSG2 Gene

No ASD Table

Relevant External Links for PSG2 Gene

GeneLoc Exon Structure for
PSG2
ECgene alternative splicing isoforms for
PSG2

Expression for PSG2 Gene

mRNA expression in normal human tissues for PSG2 Gene

mRNA differential expression in normal tissues according to GTEx for PSG2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.4), Skin - Not Sun Exposed (Suprapubic) (x4.3), and Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for PSG2 Gene

This gene is overexpressed in Placenta (58.5) and Heart (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG2 Gene



SOURCE GeneReport for Unigene cluster for PSG2 Gene Hs.709200

genes like me logo Genes that share expression patterns with PSG2: view

Protein tissue co-expression partners for PSG2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PSG2 Gene

Orthologs for PSG2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 20 (a)
ManyToMany
CEACAM1 36
  • 28 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 27 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm5155 36
  • 7 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia PSG2 36
  • 93 (a)
OneToOne
Species with no ortholog for PSG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG2 Gene

ENSEMBL:
Gene Tree for PSG2 (if available)
TreeFam:
Gene Tree for PSG2 (if available)

Paralogs for PSG2 Gene

(23) SIMAP similar genes for PSG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSG2: view

Variants for PSG2 Gene

Sequence variations from dbSNP and Humsavar for PSG2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_016039 -
VAR_049918 -
VAR_049919 -
VAR_049920 -

Structural Variations from Database of Genomic Variants (DGV) for PSG2 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV Deletion 17116639
dgv15e196 CNV Deletion 17116639
dgv1087e1 CNV Complex 17122850
dgv1088e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
dgv3890n71 CNV Gain 21882294
dgv1089e1 CNV Complex 17122850
dgv141e55 CNV Loss 17911159
dgv3891n71 CNV Gain 21882294
nsv828554 CNV Gain 20364138
dgv3895n71 CNV Loss 21882294
nsv470143 CNV Gain 18288195
dgv409n27 CNV Loss 19166990
dgv410n27 CNV Gain 19166990
dgv411n27 CNV Loss 19166990
esv2663048 CNV Deletion 23128226
nsv911839 CNV Gain+Loss 21882294
dgv3898n71 CNV Loss 21882294
dgv1091e1 CNV Complex 17122850
esv22277 CNV Gain+Loss 19812545
dgv3901n71 CNV Loss 21882294
esv2718595 CNV Deletion 23290073
nsv817843 CNV Gain 17921354
nsv470145 CNV Loss 18288195
dgv3905n71 CNV Gain 21882294
dgv3906n71 CNV Loss 21882294
dgv565e201 CNV Deletion 23290073
dgv414n27 CNV Gain 19166990
dgv415n27 CNV Gain 19166990
dgv416n27 CNV Loss 19166990
dgv417n27 CNV Loss 19166990
esv2751794 CNV Gain 17911159
esv2718602 CNV Deletion 23290073
nsv458653 CNV Loss 19166990
dgv3919n71 CNV Loss 21882294
dgv3920n71 CNV Gain 21882294
dgv3921n71 CNV Loss 21882294
esv2421574 OTHER Complex 20811451
dgv419n27 CNV Gain 19166990
dgv3922n71 CNV Gain 21882294
nsv912001 CNV Gain 21882294
nsv833837 CNV Gain 17160897
nsv469727 CNV Loss 16826518
dgv3923n71 CNV Loss 21882294
dgv3924n71 CNV Loss 21882294
dgv1092e1 CNV Complex 17122850
nsv912016 CNV Gain+Loss 21882294
nsv912017 CNV Loss 21882294
dgv3925n71 CNV Gain 21882294
dgv3926n71 CNV Gain 21882294
dgv420n27 CNV Loss 19166990
dgv421n27 CNV Gain 19166990
nsv437832 CNV Loss 16327808
esv2657641 CNV Deletion 23128226
dgv1093e1 CNV Complex 17122850
nsv817844 CNV Loss 17921354
dgv1094e1 CNV Complex 17122850
dgv3927n71 CNV Gain 21882294
dgv3928n71 CNV Gain 21882294
dgv3929n71 CNV Gain 21882294
dgv3930n71 CNV Gain 21882294
esv2718603 CNV Deletion 23290073
dgv3931n71 CNV Loss 21882294
nsv912041 CNV Loss 21882294
nsv912042 CNV Gain+Loss 21882294
nsv912046 CNV Gain+Loss 21882294
nsv442767 CNV CNV 18776908
nsv912047 CNV Gain 21882294
dgv3932n71 CNV Gain 21882294
nsv912054 CNV Loss 21882294
esv2751795 CNV Loss 17911159
nsv817845 CNV Loss 17921354
dgv422n27 CNV Loss 19166990
nsv817846 CNV Gain+Loss 17921354
dgv3933n71 CNV Gain 21882294
dgv3934n71 CNV Loss 21882294
dgv3935n71 CNV Gain 21882294
nsv458700 CNV Loss 19166990
nsv817847 CNV Gain 17921354
dgv3936n71 CNV Gain 21882294
dgv3937n71 CNV Loss 21882294
nsv912073 CNV Loss 21882294

Variation tolerance for PSG2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSG2 Gene

Disorders for PSG2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PSG2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
pancreatic cancer
  • pancreatic carcinoma, somatic
microinvasive gastric cancer
  • early gastric cancer
secretory meningioma
  • meningioma
bronchus cancer
  • malignant neoplasm of bronchus and lung, unspecified
- elite association - COSMIC cancer census association via MalaCards
Search PSG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSG2
genes like me logo Genes that share disorders with PSG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSG2 Gene

Publications for PSG2 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 67
  2. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PMID: 2377620) Leslie K.K. … Chou J.Y. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3
  3. 3D origami electrochemical immunodevice for sensitive point-of-care testing based on dual-signal amplification strategy. (PMID: 25048447) Ma C. … Yan M. (Biosens Bioelectron 2015) 3
  4. Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer. (PMID: 20119979) Huh J.W. … Kim Y.J. (J Surg Oncol 2010) 23
  5. Transient carcinoembryonic antigen elevations during adjuvant chemotherapy for colorectal cancer reflect the burden of residual micrometastatic disease. (PMID: 20378505) Yau T. … Epstein R.J. (Clin Colorectal Cancer 2010) 23

Products for PSG2 Gene

Sources for PSG2 Gene

Content