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Aliases for PSG2 Gene

Aliases for PSG2 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 2 2 3 5
  • Pregnancy-Specific Beta-1-Glycoprotein 7 2 3
  • Pregnancy-Specific Beta-1 Glycoprotein E 3 4
  • Pregnancy-Specific Glycoprotein 2 3 4
  • Carcinoembryonic Antigen SG8 2 3
  • PS-Beta-G-2 3 4
  • PS-Beta-E 3 4
  • PSBG-2 3 4
  • PSBG2 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 2 3
  • Pregnancy-Specific Beta-1 Glycoprotein 2
  • PSG1 3
  • CEA 3

External Ids for PSG2 Gene

Previous HGNC Symbols for PSG2 Gene

  • PSBG2

Previous GeneCards Identifiers for PSG2 Gene

  • GC19M044217
  • GC19M043763
  • GC19M048083
  • GC19M048099
  • GC19M048260
  • GC19M048122
  • GC19M043568
  • GC19M040000

Summaries for PSG2 Gene

Entrez Gene Summary for PSG2 Gene

  • The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG2 Gene

PSG2 (Pregnancy Specific Beta-1-Glycoprotein 2) is a Protein Coding gene. Diseases associated with PSG2 include Colorectal Cancer and Microinvasive Gastric Cancer. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is PSG11.

Gene Wiki entry for PSG2 Gene

Additional gene information for PSG2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG2 Gene

Genomics for PSG2 Gene

Regulatory Elements for PSG2 Gene

Enhancers for PSG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H043077 0.8 Ensembl ENCODE 0.7 +4.0 4034 3 FOSL1 PKNOX1 ZNF791 JUND ZFP37 CREB1 ZNF45 ZNF155 ZNF526 PSG4 ZNF284 ENSG00000231412 PSG2 GC19M043036
GH19H043059 0.2 ENCODE 0.3 +22.4 22439 1 ENSG00000231412 PSG4 GC19M043036 PSG2
GH19H043060 0.2 ENCODE 0.3 +23.4 23382 0 POU2F2 GC19M043036 PSG2
GH19H043061 0.2 ENCODE 0.3 +21.5 21482 0 PSG4 GC19M043036 PSG2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PSG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG2 Gene

Chromosome:
19
Start:
43,064,210 bp from pter
End:
43,083,045 bp from pter
Size:
18,836 bases
Orientation:
Minus strand

Genomic View for PSG2 Gene

Genes around PSG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG2 Gene

Proteins for PSG2 Gene

  • Protein details for PSG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11465-PSG2_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 2
    Protein Accession:
    P11465
    Secondary Accessions:
    • Q8TCD9
    • Q9UEA4
    • Q9UQ78

    Protein attributes for PSG2 Gene

    Size:
    335 amino acids
    Molecular mass:
    37216 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSG2 Gene

Post-translational modifications for PSG2 Gene

  • Glycosylation at isoforms=61, Asn104, isoforms=111, and Asn199
  • Modification sites at PhosphoSitePlus

Other Protein References for PSG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSG2 Gene

Domains & Families for PSG2 Gene

Gene Families for PSG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PSG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11465

UniProtKB/Swiss-Prot:

PSG2_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG2: view

Function for PSG2 Gene

Molecular function for PSG2 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 2,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Phenotypes From GWAS Catalog for PSG2 Gene

Gene Ontology (GO) - Molecular Function for PSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PSG2: view

Phenotypes for PSG2 Gene

genes like me logo Genes that share phenotypes with PSG2: view

Animal Model Products

CRISPR Products

miRNA for PSG2 Gene

miRTarBase miRNAs that target PSG2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PSG2
  • Applied Biological Materials Clones for PSG2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG2 Gene

Localization for PSG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSG2 gene
Compartment Confidence
extracellular 4
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSG2 Gene

Pathways & Interactions for PSG2 Gene

genes like me logo Genes that share pathways with PSG2: view

Pathways by source for PSG2 Gene

Interacting Proteins for PSG2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000385706%0d%0a9606.ENSP00000387365%0d%0a
Selected Interacting proteins: P11465-PSG2_HUMAN ENSP00000385706 for PSG2 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for PSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy NAS 3260773
GO:0016477 cell migration NAS 3260773
genes like me logo Genes that share ontologies with PSG2: view

No data available for SIGNOR curated interactions for PSG2 Gene

Drugs & Compounds for PSG2 Gene

(16) Drugs for PSG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(19) Additional Compounds for PSG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSG2: view

Transcripts for PSG2 Gene

mRNA/cDNA for PSG2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSG2 Gene

Pregnancy specific beta-1-glycoprotein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PSG2
  • Applied Biological Materials Clones for PSG2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PSG2 Gene

No ASD Table

Relevant External Links for PSG2 Gene

GeneLoc Exon Structure for
PSG2
ECgene alternative splicing isoforms for
PSG2

Expression for PSG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSG2 Gene

mRNA differential expression in normal tissues according to GTEx for PSG2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.4), Skin - Not Sun Exposed (Suprapubic) (x4.3), and Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for PSG2 Gene

This gene is overexpressed in Placenta (58.5) and Heart (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG2 Gene



Protein tissue co-expression partners for PSG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PSG2 Gene:

PSG2

SOURCE GeneReport for Unigene cluster for PSG2 Gene:

Hs.709200
genes like me logo Genes that share expression patterns with PSG2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSG2 Gene

Orthologs for PSG2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSG2 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEACAM1 34
  • 28 (a)
ManyToMany
-- 34
  • 20 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 27 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm5155 34
  • 7 (a)
ManyToMany
Species where no ortholog for PSG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG2 Gene

ENSEMBL:
Gene Tree for PSG2 (if available)
TreeFam:
Gene Tree for PSG2 (if available)

Paralogs for PSG2 Gene

(23) SIMAP similar genes for PSG2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PSG2 Gene

genes like me logo Genes that share paralogs with PSG2: view

Variants for PSG2 Gene

Sequence variations from dbSNP and Humsavar for PSG2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000165890 -- 43,063,851(+) TCTCT(C/T)TATAG downstream-variant-500B
rs1000353513 -- 43,083,368(+) TCCCT(A/G)GGGTT upstream-variant-2KB
rs1000730808 -- 43,083,481(+) CCCGT(G/T)GTGGT upstream-variant-2KB
rs1000930655 -- 43,070,403(+) ATGTT(C/T)AGAGA intron-variant
rs1000941378 -- 43,070,151(+) ACACA(C/T)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSG2 Gene

Variant ID Type Subtype PubMed ID
dgv140e55 CNV gain 17911159
dgv141e55 CNV loss 17911159
dgv143n111 CNV deletion 26073780
dgv145n111 CNV duplication 26073780
dgv15e196 CNV deletion 17116639
dgv3556n100 CNV gain 25217958
dgv3557n100 CNV gain 25217958
dgv3566n100 CNV gain 25217958
dgv3570n100 CNV gain+loss 25217958
dgv3571n100 CNV loss 25217958
dgv3572n100 CNV gain+loss 25217958
dgv3573n100 CNV loss 25217958
dgv3574n100 CNV gain 25217958
dgv3577n100 CNV gain 25217958
dgv3578n100 CNV gain 25217958
dgv3581n100 CNV loss 25217958
dgv3582n100 CNV gain 25217958
dgv3583n100 CNV loss 25217958
dgv3584n100 CNV gain 25217958
dgv3585n100 CNV loss 25217958
dgv3586n100 CNV loss 25217958
dgv3587n100 CNV gain 25217958
dgv409n27 CNV loss 19166990
dgv410n27 CNV gain 19166990
dgv411n27 CNV loss 19166990
dgv414n27 CNV gain 19166990
dgv415n27 CNV gain 19166990
dgv416n27 CNV loss 19166990
dgv417n27 CNV loss 19166990
dgv419n27 CNV gain 19166990
dgv420n27 CNV loss 19166990
dgv421n27 CNV gain 19166990
dgv422n27 CNV loss 19166990
dgv523e201 CNV deletion 23290073
dgv524e201 CNV deletion 23290073
dgv6465n54 CNV loss 21841781
dgv6466n54 CNV gain 21841781
dgv6467n54 CNV loss 21841781
dgv6470n54 CNV gain 21841781
dgv6471n54 CNV loss 21841781
dgv6474n54 CNV loss 21841781
dgv6479n54 CNV gain 21841781
dgv6480n54 CNV gain+loss 21841781
dgv6483n54 CNV loss 21841781
dgv6484n54 CNV gain 21841781
dgv6485n54 CNV loss 21841781
dgv6487n54 CNV loss 21841781
dgv6488n54 CNV gain 21841781
dgv6489n54 CNV loss 21841781
dgv6490n54 CNV loss 21841781
dgv6491n54 CNV loss 21841781
dgv6492n54 CNV gain 21841781
dgv662e214 CNV loss 21293372
dgv663e214 CNV loss 21293372
dgv73e203 CNV gain+loss 21179565
esv22277 CNV gain+loss 19812545
esv2421574 OTHER complex 20811451
esv2422471 CNV deletion 17116639
esv2657641 CNV deletion 23128226
esv2663048 CNV deletion 23128226
esv2718595 CNV deletion 23290073
esv2718602 CNV deletion 23290073
esv2718603 CNV deletion 23290073
esv2751794 CNV gain 17911159
esv2751795 CNV loss 17911159
esv2758763 CNV gain+loss 17122850
esv3556430 CNV deletion 23714750
esv3556432 CNV deletion 23714750
esv3644411 CNV loss 21293372
esv3644441 CNV gain 21293372
esv3893210 CNV loss 25118596
esv3893212 CNV loss 25118596
esv3893213 CNV gain 25118596
esv3893216 CNV gain+loss 25118596
esv3893217 CNV gain 25118596
esv3893218 CNV gain+loss 25118596
nsv1055355 CNV gain 25217958
nsv1055792 CNV loss 25217958
nsv1056073 CNV loss 25217958
nsv1057657 CNV gain 25217958
nsv1058422 CNV loss 25217958
nsv1061778 CNV gain 25217958
nsv1064267 CNV gain+loss 25217958
nsv1064459 CNV loss 25217958
nsv1064717 CNV gain+loss 25217958
nsv1160634 CNV duplication 26073780
nsv1160637 CNV duplication 26073780
nsv437832 CNV loss 16327808
nsv442767 CNV gain+loss 18776908
nsv458653 CNV loss 19166990
nsv458700 CNV loss 19166990
nsv469727 CNV loss 16826518
nsv470143 CNV gain 18288195
nsv470145 CNV loss 18288195
nsv516973 CNV gain+loss 19592680
nsv579687 CNV gain+loss 21841781
nsv579702 CNV loss 21841781
nsv579736 CNV gain 21841781
nsv579759 CNV loss 21841781
nsv579778 CNV loss 21841781
nsv579779 CNV loss 21841781
nsv579780 CNV gain+loss 21841781
nsv817843 CNV gain 17921354
nsv817844 CNV loss 17921354
nsv817845 CNV loss 17921354
nsv817846 CNV gain+loss 17921354
nsv817847 CNV gain 17921354
nsv828554 CNV gain 20364138
nsv833837 CNV gain 17160897
nsv963056 CNV duplication 23825009
nsv9730 CNV gain+loss 18304495

Variation tolerance for PSG2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSG2 Gene

Disorders for PSG2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PSG2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
microinvasive gastric cancer
  • early gastric cancer
secretory meningioma
  • meningioma
gastric cancer, somatic
  • gastric cancer
- elite association - COSMIC cancer census association via MalaCards
Search PSG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSG2
genes like me logo Genes that share disorders with PSG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSG2 Gene

Publications for PSG2 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PMID: 2377620) Leslie KK … Chou JY (Proceedings of the National Academy of Sciences of the United States of America 1990) 2 3 60
  4. The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family. (PMID: 3260773) Streydio C … Vassart G (Biochemical and biophysical research communications 1988) 3 4 60
  5. 3D origami electrochemical immunodevice for sensitive point-of-care testing based on dual-signal amplification strategy. (PMID: 25048447) Ma C … Yan M (Biosensors & bioelectronics 2015) 3 60

Products for PSG2 Gene

  • Addgene plasmids for PSG2

Sources for PSG2 Gene

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