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PSG1 Gene

protein-coding   GIFtS: 50
GCID: GC19M043348

Pregnancy Specific Beta-1-Glycoprotein 1


(Previous symbol: PSBG1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pregnancy Specific Beta-1-Glycoprotein 11 2     PSGGA2 3
PSBG11 2 3 5     CD66 Antigen-Like Family Member F2 3
B1G12 3 5     SP12 5
Fetal Liver Non-Specific Cross-Reactive Antigen 1/22 3     CD66f2
Pregnancy-Specific Beta-1 Glycoprotein C/D2 3     DHFRP22
Pregnancy-Specific Glycoprotein 12 3     PBG12
FL-NCA-1/22 3     PSGIIA2
PS-beta-C/D2 3     Pregnancy-Specific B-1 Glycoprotein2
PS-beta-G-12 3     Pregnancy-Specific Beta-1-Glycoprotein 12
PSBG-12 3     CD66f Antigen3
PSG952 3     

External Ids:    HGNC: 95141   Entrez Gene: 56692   Ensembl: ENSG000002319247   OMIM: 1763905   UniProtKB: P114643   

Export aliases for PSG1 gene to outside databases

Previous GC identifers: GC19M044018 GC19M043762 GC19M048024 GC19M048062 GC19M048063 GC19M047923 GC19M039800


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSG1 Gene:
The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that
support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of
the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne
et al., 1976 (PubMed 971765)). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988
(PubMed 3257488); Streydio et al., 1988 (PubMed 3260773)).(supplied by OMIM, Oct 2009)

GeneCards Summary for PSG1 Gene:
PSG1 (pregnancy specific beta-1-glycoprotein 1) is a protein-coding gene. Diseases associated with PSG1 include factor vii deficiency, and trophoblastic neoplasm. An important paralog of this gene is PSG9.

Gene Wiki entry for PSG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PSG1 gene promoter:
         AREB6   c-Myb   Pax-2   Pax-2a   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPSG1 promoter sequence
   Search Chromatin IP Primers for PSG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

PSG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSG1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M043348:  view genomic region     (about GC identifiers)

Start:
43,370,613 bp from pter      End:
43,383,974 bp from pter
Size:
13,362 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PSG1_HUMAN, P11464 (See protein sequence)
Recommended Name: Pregnancy-specific beta-1-glycoprotein 1 precursor  
Size: 419 amino acids; 47223 Da
Developmental stage: PSBG are produced in high quantity during pregnancy
Secondary accessions: O75236 P11462 P11463 Q15231 Q15241 Q15243 Q16660 Q6ICR4 Q9P1W5 Q9UQ79
Alternative splicing: 4 isoforms:  P11464-1   P11464-2   P11464-3   P11464-4   

Explore the universe of human proteins at neXtProt for PSG1: NX_P11464

Explore proteomics data for PSG1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn61, Asn104, Asn111, Asn199, Asn259, Asn268, Asn303

  • See PSG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171754.1  NP_001171755.1  NP_008836.2  

    ENSEMBL proteins: 
     ENSP00000413041   ENSP00000472284   ENSP00000472610   ENSP00000385386   ENSP00000308970  
     ENSP00000244296   ENSP00000470690   ENSP00000469575  

    PSG1 Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for PSG1
    Novus Biologicals PSG1 Protein
    Novus Biologicals PSG1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PSG1

    PSG1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PSG1 (PSG-1)
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    Abcam antibodies for PSG1
    Cloud-Clone Corp. Antibodies for PSG1
    ThermoFisher Antibodies for PSG1
    LSBio Antibodies in human, mouse, rat for PSG1

    PSG1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PSG1
    R&D Systems ELISAs for PSG1 (PSG-1)
    GenScript Custom Assay Services for PSG1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PSG1
    Cloud-Clone Corp. CLIAs for PSG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P11464

    ProtoNet protein and cluster: P11464

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PSG1_HUMAN, P11464
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    PSG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for PSG1:
    pregnancy specific beta-1-glycoprotein 1,expressed by placental syncytiotrophoblasts,unknown
    function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    PSG1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PSG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PSG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PSG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PSG1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for PSG1 (see all 996):
    ABCA1,  ABCA7,  ABCB9,  ABCC10,  ABCC3,  ABCC4,  ABCC6,  ABCC6P1,  ABCC6P2,  ABCC8

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate PSG1
    SwitchGear 3'UTR luciferase reporter plasmidPSG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PSG1
    Predesigned siRNA for gene silencing in human, mouse, rat PSG1

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for PSG1 (see all 15)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PSG1 (NM_001184826)
    Sino Biological Human cDNA Clone for PSG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSG1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PSG1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PSG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSG1_HUMAN, P11464: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    mitochondrion2
    plasma membrane2
    chloroplast1
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    PSG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSG1 (see all 11)
        ErbB2-ErbB3 Heterodimers
    HMGB1 Pathway
    JAK-STAT Pathway
    Estrogen Pathway
    Signaling in Gap Junctions



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PSG1
    Interactions:

        Search GeneGlobe Interaction Network for PSG1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PSG1 (P114643 ENSP000002442964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UTP14AQ9BVJ63, ENSP000003779444I2D: score=3 STRING: ENSP00000377944
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007565female pregnancy TAS1572651

    PSG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PSG1

    4 Novoseek inferred chemical compound relationships for PSG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oestriol 57 2 1694994 (1), 10416969 (1)
    progesterone 4.08 2 8567857 (1), 9740458 (1)
    estradiol 0 5 9219458 (5)
    zinc 0 2 11352651 (1)



    PSG1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PSG1 gene (3 alternative transcripts): 
    NM_001184825.1  NM_001184826.1  NM_006905.2  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436291(uc002ovb.3 uc002ovc.3 uc002ova.2 uc002ouz.2)
    ENST00000602039 ENST00000595124 ENST00000595356 ENST00000403380 ENST00000312439
    ENST00000244296(uc002oug.1 uc002oun.3 uc002ovd.1) ENST00000597058
    ENST00000595930 ENST00000601456 ENST00000601073
    miRNA
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    Block miRNA regulation of human, mouse, rat PSG1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PSG1
    SwitchGear 3'UTR luciferase reporter plasmidPSG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PSG1
    Predesigned siRNA for gene silencing in human, mouse, rat PSG1
    Clone
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    OriGene clones in human, mouse for PSG1 (see all 15)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PSG1 (NM_001184826)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSG1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PSG1
    OriGene qSTAR qPCR primer pairs in human, mouse for PSG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PSG1
      QuantiTect SYBR Green Assays in human, mouse, rat PSG1
      QuantiFast Probe-based Assays in human, mouse, rat PSG1

    Selected AceView cDNA sequences (see all 93):

    CR613770 CR594658 CR595633 CR609860 CR601051 CR614244 CR616751 CR609429 
    CR620325 BI056469 CR604293 CR626276 CR605150 BC022338 CR450329 CR617145 
    CR626825 CR609859 CR612366 NM_006905 M21822 CR619567 CR612139 NM_182707 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSG1 expression in normal human tissues (normalized intensities)      PSG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCACCTTT
    PSG1 Expression
    About this image


    PSG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    PSG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSG1 Protein Expression
        Custom PCR Arrays for PSG1
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    QuantiFast Probe-based Assays in human, mouse, rat PSG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for PSG1 (if available)
    TreeFam Gene Tree for PSG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSG1 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
    PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  PSG22  
    CEACAM162  PSG42  PSG72  CEACAM32  
    Selected SIMAP similar genes for PSG1 using alignment to 14 protein entries:     PSG1_HUMAN (see all proteins) (see all similar genes):
    DHFRP2    PSG    PSG2    PSGII    PSG11    PSG8
    PSG5    PSG4    PSG3    PSG6    PSG7    CEA
    PSG9    CEACAM8    CEACAM7    CEACAM3    CEACAM1    CEACAM6

    PSG1 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for PSG1
    PGOHUM00000250578 PGOHUM00000234341 PGOHUM00000234344 PGOHUM00000259342


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSG1 (see all 827)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58281531,2
    C--39813729(+) cacag-/ACAC  
      ACACAC
    acaca
    3 -- us2k10--------
    rs601897741,2
    C--43370124(+) TCTCCA/GTTGGA 2 -- ds50010--------
    rs116702371,2
    C,F,H--43370213(+) GTCTGC/TTAAGG 2 -- ds500110Minor allele frequency- T:0.02NS EA NA 1174
    rs1876602171,2
    --43370221(+) AGGCAA/TTGCCA 2 -- ds50010--------
    rs1150696131,2
    F--43370364(+) TTGCAG/ATGGAC 2 -- ds50011Minor allele frequency- A:0.14WA 118
    rs1455863861,2
    --43370366(+) GCAGTA/GGACTG 2 -- ds50010--------
    rs1169874861,2
    C,F--43370389(+) GGATGC/TCAGGT 2 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1435120031,2
    --43370395(+) CAGGTA/GTCCCA 2 -- ds50010--------
    rs1921934321,2
    --43370396(+) AGGTAC/TCCCAT 2 -- ds50010--------
    rs1140455651,2
    F--43370442(+) ATGGGC/TTTGTA 2 -- ds50011Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for PSG1 (43370613 - 43383974 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PSG1 (see all 74):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv15e196CNV Deletion17116639
    esv2422471CNV Deletion17116639
    esv2718597CNV Deletion23290073
    dgv565e201CNV Deletion23290073
    esv2668472CNV Deletion23128226
    esv2663048CNV Deletion23128226
    dgv564e201CNV Deletion23290073
    esv2718595CNV Deletion23290073
    esv2718598CNV Deletion23290073
    nsv471409CNV Duplication19718026

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSG1
    DNA2.0 Custom Variant and Variant Library Synthesis for PSG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176390    OMIM disorders: --

    15 diseases for PSG1:    About MalaCards
    factor vii deficiency    trophoblastic neoplasm    gestational trophoblastic neoplasm    germinoma
    down syndrome    choriocarcinoma    transitional cell carcinoma    eclampsia
    pre-eclampsia    basal cell carcinoma    infertility    esophagitis
    lung cancer    adenocarcinoma    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for PSG1:
    Gestational trophoblastic neoplasm

    PSG1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PSG1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydatidiform mole 52.4 2 2364798 (2)
    down syndrome 50.1 10 2146876 (3), 7925075 (2), 7528054 (1), 1387478 (1) (see all 7)
    gestational trophoblastic disease 49.3 1 1699189 (1)
    carcinoma large cell 45.8 1 7590693 (1)
    trisomy 39.4 9 10416969 (4), 7528054 (2), 1387478 (1)
    choriocarcinoma 31.8 1 8403104 (1)
    preeclampsia 31.4 8 14678084 (4), 12457454 (2), 12648442 (1), 19911417 (1)
    adenocarcinoma 26.7 4 7703564 (1), 7590693 (1), 9337537 (1), 9511851 (1)
    pregnancy ectopic 25.7 2 2364798 (2)
    lung carcinoma 20.3 3 9511851 (2), 7590693 (1)


    Export disorders for PSG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSG1 gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with PSG1)
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    1. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PubMed id 2377620)1, 2, 9 Leslie K.K.... Chou J.Y. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning. (PubMed id 2350345)1, 2 Zoubir F.... Hammarstroem S. (Biochem. Biophys. Res. Commun. 1990)
    5. Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement. (PubMed id 2735907)1, 2 Khan W.N. and Hammarstroem S. (Biochem. Biophys. Res. Commun. 1989)
    6. cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. (PubMed id 2783133)1, 2 Zimmermann W.A.... Thompson J.A. (Biochem. Biophys. Res. Commun. 1989)
    7. Molecular cloning and expression of cDNA for a carcinoembryonic antigen-related fetal liver glycoprotein. (PubMed id 2541441)1, 2 Khan W.N.... Hammarstroem S. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    8. Characterization of cDNA encoding human pregnancy-specific beta 1- glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen. (PubMed id 3180995)1, 2 Chan W.-Y.... Shupert W.L. (DNA 1988)
    9. Isolation and characterization of complementary DNAs encoding human pregnancy-specific beta 1-glycoprotein. (PubMed id 3257488)1, 2 Watanabe S. and Chou J.Y. (J. Biol. Chem. 1988)
    10. The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family. (PubMed id 3260773)1, 2 Streydio C.... Vassart G. (Biochem. Biophys. Res. Commun. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5669 HGNC: 9514 AceView: PSG1 Ensembl:ENSG00000231924 euGenes: HUgn5669
    ECgene: PSG1 H-InvDB: PSG1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSG1 gene:
    Search GeneIP for patents involving PSG1

    GeneCards and IP:
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