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PSG1 Gene

protein-coding   GIFtS: 51

GC19M048063
pregnancy specific beta-1-glycoprotein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PSBG1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
B1G1 2, 3, 5
CD66f 1, 2
DHFRP2 2
FL-NCA-1/2 3
FLJ90598 2
FLJ90654 2
PBG1 1, 2
PS-beta-C/D 3
PSBG-1 3
PSBG1 2, 3, 5
PSG95 3
PSGGA 1, 2, 3
PSGIIA 2
SP1 2, 5
Descriptions
CD66 antigen 3
CD66 antigen-like family member F 3
CD66f antigen 3
Fetal liver non-specific cross-reactive antigen 1/2 3
Pregnancy-specific beta-1 glycoprotein C/D 3
pregnancy specific beta-1-glycoprotein 1 2
pregnancy-specific B-1 glycoprotein 2
External Ids
HGNC: 95141
Entrez Gene: 56692
UniProtKB: P114643
Ensembl: ENSG000002218787
Search outside databases for aliases for PSG1 gene

Previous GC identifers: GC19M044018 GC19M043762 GC19M048024 GC19M048062 GC19M047923

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for PSG1
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PSG1 gene  

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

PSG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M048063:     (about GC identifiers)

Start:
48,049,852 bp from pter
End:
48,075,711 bp from pter
Size:
25,860 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PSG1_HUMAN, P11464 (See protein sequence)
Recommended Name: Pregnancy-specific beta-1-glycoprotein 1 precursor  
Size: 419 amino acids; 47223 Da
Subcellular location: Secreted (Potential)
Developmental stage: PSBG are produced in high quantity during pregnancy
Secondary accessions: O75236 P11462 P11463 Q15231 Q15241 Q15243 Q16660 Q9P1W5 Q9UQ79
Alternative splicing: 4 isoforms:  P11464-1   P11464-2   P11464-3   P11464-4   

REFSEQ proteins: NP_008836.2  

ENSEMBL proteins: 
ENSP00000338024 ENSP00000385556 ENSP00000385386 ENSP00000308970 ENSP00000244296 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Pregnancy Specific Glycoprotein 1)
Human Recombinant Proteins from Abnova (PSG1)
              OriGene Purified Recombinant Human Protein: PSG1 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
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Antibodies for PSG1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for PSG1
Browse R&D Systems for Antibodies
Antibodies from Abcam (Pregnancy Specific Glycoprotein 1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (PSG1)
Novus Biologicals Antibodies for PSG1

Assays for PSG1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR003598 Ig_sub2
 IPR007110 Ig-like
 IPR003599 Ig_sub
 IPR013106 Ig_V-set
 IPR013151 Ig


   GeneDecks  PSG1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P11464

ProtoNet protein and cluster: P11464

2 Blocks protein families:
IPB003598 Immunoglobulin C-2 type
IPB013106 Immunoglobulin V-set


UniProtKB/Swiss-Prot: PSG1_HUMAN, P11464
Similarity: Belongs to the immunoglobulin superfamily. CEA family
Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PSG1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006905

              Applied Biosystems Silencer® siRNAs for PSG1

              Sigma-Aldrich siRNA for PSG1  
                     Sigma-Aldrich shRNA for PSG1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for PSG1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006905
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006905
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_006905 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_006905

Genatlas biochemistry entry for PSG1:
pregnancy specific beta-1-glycoprotein 1,expressed by placental syncytiotrophoblasts,unknown
function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily
(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Interacting proteins for PSG1 (ENSP000003089703) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
DHFRL1ENSP000003191703STRING (score=.883)
CYTH4ENSP000002489013STRING (score=.817)
APOHENSP000002059483STRING (score=.742)
PTPRCENSP000003563463STRING (score=.724)
--ENSP000003305003STRING (score=.722)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007565 female pregnancy TAS1572651
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PSG1
4 Novoseek chemical compound relationships for PSG1 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
oestriol 57.89 2 1694994 (1), 10416969 (1)
progesterone 5.43 2 8567857 (1), 9740458 (1)
estradiol 0.00 5 9219458 (5)
zinc 0.00 2 11352651 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PSG1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006905

              Sigma-Aldrich siRNA for PSG1  
                     Sigma-Aldrich shRNA for PSG1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_006905  

REFSEQ mRNAs for PSG1 gene: 

NM_006905.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_006905  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006905
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006905
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_006905 

Additional cDNA sequence: 

AK056754.1 AK300152.1 AK300206.1 AK311491.1 BC022338.1 BC058285.1 CR450329.1 CR590178.1 
CR591870.1 CR594741.1 CR595633.1 CR597449.1 CR597619.1 CR599288.1 CR600097.1 CR600102.1 
CR601679.1 CR601994.1 CR602381.1 CR603734.1 CR605150.1 CR606557.1 CR609429.1 CR609859.1 
CR609860.1 CR610788.1 CR611664.1 CR612067.1 CR612366.1 CR613576.1 CR614168.1 CR614244.1 
CR616434.1 CR616593.1 CR616751.1 CR621768.1 CR622475.1 CR622724.1 CR626825.1 J04539.1 
M17908.1 M17909.1 M20879.1 M20881.1 M21822.1 M25385.1 M33663.1 M33664.1 
M34715.1 M37397.1 

24/127 DOTS entries (see all 127 ):

DT.91785493  DT.100764684  DT.101973962  DT.121424134  DT.121424052  DT.100764233  DT.100884390  DT.121424151 
DT.121424059  DT.87078483  DT.100041222  DT.102844095  DT.100829135  DT.121424719  DT.100884372  DT.100762520 
DT.121424263  DT.100884331  DT.121424479  DT.100884388  DT.121424364  DT.121424596  DT.121424266  DT.121424824 

24/93 AceView cDNA sequences (see all 93 ):

CR617145 CR612139 CR612366 BQ024077 CR609859 CR611664 CR622475 CR601994 
CR622724 NM_182707 NM_006905 M20879 CR604426 CR616593 CR600102 CR597619 
CR600148 CR619567 BC022338 CR606557 CR626276 CR599288 CR626825 CR616434 

highest scoring ESTs for PSG1:

M34715 AL541804 AL543531 BF107594 BF986579 BF994700 BF994958 BG011928 BG015792 BG435327 

Unigene Cluster for PSG1:

Pregnancy specific beta-1-glycoprotein 1
Hs.709192  [show with all ESTs]
Unigene Representative Sequence: AK056754


GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations:
ENST00000336155  ENST00000406070  ENST00000403380  ENST00000312439  ENST00000244296  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PSG1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for PSG1

1 / 2 / 3

8 probe-sets matching PSG1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

40858_at2, 3 U95-A 1 1.00 1.00 0.88 0.80 M34715 0.80 1.00 0.91 1

35956_s_at2, 3 U95-A 6 0.81 0.16 0.97 1.20 U18467 0.40 0.33 0.37 2

210195_s_at2, 3 U133-A 2 1.00 0.95 -- -- M34715 0.80 1.00 0.91 1

210196_s_at2, 3 U133-A 4 1.00 0.64 -- -- M33663 0.60 1.00 0.82 1

208257_x_at2, 3 U133-A 7 1.00 0.41 -- -- NM_006905 0.60 0.70 0.65 1

210195_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --

210196_s_at2 U133Plus2 4 1.00 0.64 -- -- -- -- -- -- --

208257_x_at2 U133Plus2 7 1.00 0.41 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TACCACCTTT

SOURCE GeneReport for Unigene cluster: Hs.709192

Expression variation in blood from EXPOLDB for PSG1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for PSG1 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
PSG11   -- pregnancy specific beta-1-glycoprotein 1 94.93(n)
89.37(a)
456086  XM_001155119.1  XP_001155119.1 
About this table        Species with no ortholog for PSG1

ENSEMBL Gene Tree for PSG1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for PSG1 gene
PSG52  PSG92  PSG82  PSG62  CEACAM52  PSG112  CEACAM12  CEACAM82  
PSG32  CEACAM72  CEACAM62  PSG22  PSG72  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/207 NCBI SNPs in PSG1 are shown (see all 207 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 8)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs104058541,2
A,C,F,H48076260(+) TCCTTT/CCTGGC 1 -- ng314Minor allele frequency- C:0.42EU EA WA 360
--
rs7077451,2
A,C,F,H48074208(+) TTTGGT/GTGGCT 1 P/T mis19Minor allele frequency- G:0.12EU EA WA MN 1018
--
rs124591711,2
C,F,H48075641(+) GCACGG/ACTGTC 1 -- ut512Minor allele frequency- A:0.10EU WA 226
--
rs7077441,2
A,C,F48074214(+) TGGCTG/CGGCTT 1 Q/E mis11Minor allele frequency- C:0.15MN 184
--
rs10588171,2
A,C,F48062997(-) tgtacC/Gtgaag 1 -- ng511Minor allele frequency- G:0.09MN 184
--
rs10586921,2
C,F,H48067879(-) TGTCCG/AAAACC 1 K/E mis19Minor allele frequency- A:0.00MN EU EA WA 992
--
rs21084881,2
A,C48075826(+) TGTGGA/CGGCCT 1 -- ng310--------
--
rs31997071,2
A,F48063877(-) ccaagC/Gaggaa 1 -- ut311Minor allele frequency- G:0.07MN 184
--
rs20057721,2
A,C48077070(+) GGGGTA/GGGCAT 1 -- ng310--------
--
rs110836641,2
F,H48063702(+) ATTACG/AGTTCC 1 -- ut314Minor allele frequency- A:0.05EU EA WA 410
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HapMap Linkage Disequilibrium images for PSG1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176390

10/18 Novoseek disease relationships for PSG1 gene (see all 18 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
hydatidiform mole 53.41 2 2364798 (2)
down syndrome 51.17 10 2146876 (3), 7925075 (2), 7528054 (1), 1387478 (1) (see all 7)
gestational trophoblastic disease 50.34 1 1699189 (1)
carcinoma large cell 46.69 1 7590693 (1)
trisomy 40.42 9 10416969 (4), 7528054 (2), 1387478 (1)
choriocarcinoma 32.93 1 8403104 (1)
adenocarcinoma 28.15 4 7703564 (1), 7590693 (1), 9337537 (1), 9511851 (1)
pregnancy ectopic 26.84 2 2364798 (2)
preeclampsia 24.46 7 14678084 (4), 12457454 (2), 12648442 (1)
lung carcinoma 21.48 3 9511851 (2), 7590693 (1)
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(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/93 PubMed articles for PSG1 gene (see all 93 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5669 HGNC: 9514 AceView: PSG1 Ensembl:ENSG00000221878 euGenes: HUgn5669
ECgene: PSG1 H-InvDB: PSG1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for PSG1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for PSG1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for PSG1 Antibodies for PSG1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for PSG1 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(Pregnancy Specific Glycoprotein 1)
 Antibodies (Pregnancy Specific Glycoprotein 1)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for PSG1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for PSG1

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