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Aliases & Descriptions for PSG1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| B1G1 2, 3, 5 | | CD66f 1, 2 | | DHFRP2 2 | | FL-NCA-1/2 3 | | FLJ90598 2 | | FLJ90654 2 | | PBG1 1, 2 | | PS-beta-C/D 3 | | PSBG-1 3 | | PSBG1 2, 3, 5 | | PSG95 3 | | PSGGA 1, 2, 3 | | PSGIIA 2 | | SP1 2, 5 |
| | | Descriptions |
|---|
| CD66 antigen 3 | | CD66 antigen-like family member F 3 | | CD66f antigen 3 | | Fetal liver non-specific cross-reactive antigen 1/2 3 | | Pregnancy-specific beta-1 glycoprotein C/D 3 | | pregnancy specific beta-1-glycoprotein 1 2 | | pregnancy-specific B-1 glycoprotein 2 |
|
| | Search outside databases for aliases for PSG1 genePrevious GC identifers: GC19M044018 GC19M043762 GC19M048024 GC19M048062 GC19M047923 |
Summaries for PSG1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for PSG1 |
Genomic Location for PSG1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PSG1 gene 
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.2PSG1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M048063:
(about GC identifiers)
Start:
|
48,049,852 bp from pter |
End:
|
48,075,711 bp from pter |
Size:
|
25,860 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for PSG1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PSG1_HUMAN, P11464 (See
protein sequence)Recommended Name: Pregnancy-specific beta-1-glycoprotein 1 precursor Size: 419 amino acids; 47223 Da
Subcellular location: Secreted (Potential)
Developmental stage: PSBG are produced in high quantity during pregnancy
Secondary accessions: O75236 P11462 P11463 Q15231 Q15241 Q15243 Q16660 Q9P1W5 Q9UQ79Alternative splicing: 4 isoforms: P11464-1 P11464-2 P11464-3 P11464-4 REFSEQ proteins: NP_008836.2
ENSEMBL proteins: ENSP00000338024 ENSP00000385556 ENSP00000385386 ENSP00000308970 ENSP00000244296
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: PSG1 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | About this table
Antibodies for PSG1: Assays for PSG1: | Protein
Domains/ Families for PSG1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P11464
ProtoNet protein and cluster: P11464 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: PSG1_HUMAN, P11464Similarity: Belongs to the immunoglobulin superfamily. CEA familySimilarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain | Gene Function for PSG1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006905
Applied Biosystems Silencer® siRNAs for PSG1
Sigma-Aldrich siRNA for PSG1  Sigma-Aldrich shRNA for PSG1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006905                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006905                                  untagged cDNA clones in CMV expression vector (see all 3): NM_006905 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006905
Genatlas biochemistry entry for PSG1:pregnancy specific beta-1-glycoprotein 1,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily | Pathways & Interactions for PSG1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5 Interacting proteins for PSG1 (ENSP000003089703) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for PSG1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PSG1 4 Novoseek chemical compound relationships for PSG1 gene
About this table
|
Transcripts for PSG1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006905
Sigma-Aldrich siRNA for PSG1  Sigma-Aldrich shRNA for PSG1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006905 REFSEQ mRNAs for PSG1 gene: NM_006905.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006905               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006905                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006905                                  untagged cDNA clones in CMV expression vector (see all 3): NM_006905  Additional cDNA sequence: AK056754.1 AK300152.1 AK300206.1 AK311491.1 BC022338.1 BC058285.1 CR450329.1 CR590178.1 CR591870.1 CR594741.1 CR595633.1 CR597449.1 CR597619.1 CR599288.1 CR600097.1 CR600102.1 CR601679.1 CR601994.1 CR602381.1 CR603734.1 CR605150.1 CR606557.1 CR609429.1 CR609859.1 CR609860.1 CR610788.1 CR611664.1 CR612067.1 CR612366.1 CR613576.1 CR614168.1 CR614244.1 CR616434.1 CR616593.1 CR616751.1 CR621768.1 CR622475.1 CR622724.1 CR626825.1 J04539.1 M17908.1 M17909.1 M20879.1 M20881.1 M21822.1 M25385.1 M33663.1 M33664.1 M34715.1 M37397.1 24/127 DOTS entries (see all 127
): DT.91785493 DT.100764684 DT.101973962 DT.121424134 DT.121424052 DT.100764233 DT.100884390 DT.121424151 DT.121424059 DT.87078483 DT.100041222 DT.102844095 DT.100829135 DT.121424719 DT.100884372 DT.100762520 DT.121424263 DT.100884331 DT.121424479 DT.100884388 DT.121424364 DT.121424596 DT.121424266 DT.121424824 24/93 AceView cDNA sequences (see all 93
):CR617145 CR612139 CR612366 BQ024077 CR609859 CR611664 CR622475 CR601994 CR622724 NM_182707 NM_006905 M20879 CR604426 CR616593 CR600102 CR597619 CR600148 CR619567 BC022338 CR606557 CR626276 CR599288 CR626825 CR616434
highest scoring ESTs for PSG1:M34715 AL541804 AL543531 BF107594 BF986579 BF994700 BF994958 BG011928 BG015792 BG435327 Unigene Cluster for PSG1: Pregnancy specific beta-1-glycoprotein 1 Hs.709192 [show with all ESTs]Unigene Representative Sequence: AK056754
GeneLoc Exon Structure
5 Ensembl transcripts including schematic representations: ENST00000336155
ENST00000406070
ENST00000403380
ENST00000312439
ENST00000244296
|
Expression for PSG1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PSG1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PSG1
1 / 2 / 3 8 probe-sets matching PSG1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TACCACCTTT
SOURCE GeneReport for Unigene cluster: Hs.709192
Expression variation in blood from EXPOLDB for PSG1 |
Orthologs for PSG1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PSG1 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
chimpanzee (Pan troglodytes) |
PSG11 |
-- |
pregnancy specific beta-1-glycoprotein 1 |
94.93(n) 89.37(a) |
456086 XM_001155119.1 XP_001155119.1 |
About this table Species with no ortholog for PSG1
ENSEMBL Gene Tree for PSG1 | Paralogs for PSG1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PSG1 gene
- PSG52 PSG92 PSG82 PSG62 CEACAM52 PSG112 CEACAM12 CEACAM82
- PSG32 CEACAM72 CEACAM62 PSG22 PSG72
|
SNPs/Variants for PSG1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PSG1 (up to first 250kb)
|
Disorders & Mutations for PSG1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 176390
10/18 Novoseek disease relationships for PSG1 gene (see all 18
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hydatidiform mole |
53.41 |
2 |
2364798 (2) |
| down syndrome |
51.17 |
10 |
2146876 (3), 7925075 (2), 7528054 (1), 1387478 (1) (see all 7) |
| gestational trophoblastic disease |
50.34 |
1 |
1699189 (1) |
| carcinoma large cell |
46.69 |
1 |
7590693 (1) |
| trisomy |
40.42 |
9 |
10416969 (4), 7528054 (2), 1387478 (1) |
| choriocarcinoma |
32.93 |
1 |
8403104 (1) |
| adenocarcinoma |
28.15 |
4 |
7703564 (1), 7590693 (1), 9337537 (1), 9511851 (1) |
| pregnancy ectopic |
26.84 |
2 |
2364798 (2) |
| preeclampsia |
24.46 |
7 |
14678084 (4), 12457454 (2), 12648442 (1) |
| lung carcinoma |
21.48 |
3 |
9511851 (2), 7590693 (1) |
About this table
|
Medical News for PSG1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PSG1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/93 PubMed articles for PSG1 gene (see all 93
):- Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PubMed id 2377620)1, 3, 4 Leslie K.K.... Chou J.Y. (1990)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)3, 4 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning. (PubMed id 2350345)3, 4 Zoubir F.... Hammarstroem S. (1990)
- Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement. (PubMed id 2735907)3, 4 Khan W.N. and Hammarstroem S. (1989)
- cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. (PubMed id 2783133)3, 4 Zimmermann W.A.... Thompson J.A. (1989)
- Molecular cloning and expression of cDNA for a carcinoembryonic antigen-related fetal liver glycoprotein. (PubMed id 2541441)3, 4 Khan W.N.... Hammarstroem S. (1989)
- Characterization of cDNA encoding human pregnancy-specific beta 1- glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen. (PubMed id 3180995)3, 4 Chan W.-Y.... Shupert W.L. (1988)
- Isolation and characterization of complementary DNAs encoding human pregnancy-specific beta 1-glycoprotein. (PubMed id 3257488)3, 4 Watanabe S. and Chou J.Y. (1988)
- The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family. (PubMed id 3260773)3, 4 Streydio C.... Vassart G. (1988)
|
Search for PSG1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PSG1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PSG1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PSG1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PSG1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for PSG1:

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