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PSEN1 Gene

protein-coding   GIFtS: 73
GCID: GC14P073603

Presenilin 1

(Previous name: Alzheimer disease 3)
(Previous symbol: AD3)
  See PSEN1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Presenilin 11 2     S1822
AD31 2 3 5     presenilin-12
PS-12 3     EC 3.4.23.-3
PS12 3     PSNL13
Alzheimer Disease 31     Protein S1823
FAD2     EC 3.4.238

External Ids:    HGNC: 95081   Entrez Gene: 56632   Ensembl: ENSG000000808157   OMIM: 1043115   UniProtKB: P497683   

Export aliases for PSEN1 gene to outside databases

Previous GC identifers: GC14P071108 GC14P067398 GC14P071592 GC14P071593 GC14P072672 GC14P053768


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PSEN1 Gene:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins
(PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased
production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains).
Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that
cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such
that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several
alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the
full-length nature of only some have been determined. (provided by RefSeq, Aug 2008)

GeneCards Summary for PSEN1 Gene:
PSEN1 (presenilin 1) is a protein-coding gene. Diseases associated with PSEN1 include alzheimer disease, type 3, with spastic paraparesis and apraxia, and psen1-related dilated cardiomyopathy. GO annotations related to this gene include PDZ domain binding and calcium channel activity. An important paralog of this gene is PSEN2.

UniProtKB/Swiss-Prot: PSN1_HUMAN, P49768
Function: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the
intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor
protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role
in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates
cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or
calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the
pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis

summary for PSEN1 Gene:
Secretases are a group of enzymes involved in the proteolytic cleavage of amyloid precursor protein (APP).
There are three types of secretases, alpha-secretase, beta-secretase and gamma-secretase. gamma-Secretase is
a multi-subunit internal protease that cleaves within the transmembrane domain of its substrates. It is
itself an integral membrane protein and minimally consists of four proteins; presenilin, nicastrin, APH-1
and PEN-2. Presenilin is an aspartic protease and the catalytic subunit of the complex. There are two
important substrates of gamma-secretase; amyloid precursor protein (APP) and Notch. gamma-secretase can
cleave several sites within APP, and the most common products are Abeta40 and Abeta42. Abeta42 is
fibrillogenic and associated with disease states, notably Alzheimer's disease. gamma-Secretase catalyzes the
second step in Notch protein cleavage. gamma-Secretase cleaves within the transmembrane domain of Notch,
releasing the intracellular domain (Nbeta) into the cytoplasm. Nbeta moves to the nucleus where it can
regulate gene expression by activating the transcription factor CSL. This gamma-secretase-Notch signaling
pathway has a role in promoting angiogenesis in the embryo and wound healing in the adult.

Gene Wiki entry for PSEN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PSEN1 gene promoter:
         AREB6   PPAR-gamma1   AML1a   Cart-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PSEN1 promoter sequence
   Search Chromatin IP Primers for PSEN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PSEN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.3

PSEN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSEN1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P073603:  view genomic region     (about GC identifiers)

Start:
73,603,126 bp from pter      End:
73,690,399 bp from pter
Size:
87,274 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PSN1_HUMAN, P49768 (See protein sequence)
Recommended Name: Presenilin-1  
Size: 467 amino acids; 52668 Da
Subunit: Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1
or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase
activity. Other components which are associated with the complex include SLC25A64, SLC5A7, PHB and PSEN1 isoform
3. Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment. Associates
with proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Associates
with NOTCH1. Associates with cadherin/catenin adhesion complexes through direct binding to CDH1 or CDH2.
Interaction with CDH1 stabilizes the complex and stimulates cell-cell aggregation. Interaction with CDH2 is
essential for trafficking of CDH2 from the endoplasmic reticulum to the plasma membrane. Interacts with CTNND2,
CTNNB1, HERPUD1, FLNA, FLNB, MTCH1, PKP4 and PARL. Interacts through its N-terminus with isoform 3 of GFAP.
Interacts with DOCK3 (By similarity)
1 PDB 3D structure from and Proteopedia for PSEN1:
2KR6 (3D)    
Secondary accessions: B2R6D3 O95465 Q14762 Q15719 Q15720 Q96P33 Q9UIF0
Alternative splicing: 7 isoforms:  P49768-1   P49768-2   P49768-3   P49768-4   P49768-5   P49768-6   P49768-7   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for PSEN1: NX_P49768

Explore proteomics data for PSEN1 at MOPED

Post-translational modifications: 

  • Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35
    and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to
    produce the fragment, PS1-CTF121
  • After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC.
    Phosphorylation on Ser-346 inhibits endoproteolysis1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PSEN1 (P49768) (see all 27)
     IHWKGPL  VPVTLCM  LGPHRST  DYITVAL 


    See PSEN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000012.1  NP_015557.2  

    ENSEMBL proteins: 
     ENSP00000451498   ENSP00000451588   ENSP00000452128   ENSP00000450551   ENSP00000451880  
     ENSP00000451674   ENSP00000452477   ENSP00000451662   ENSP00000377712   ENSP00000350342  
     ENSP00000326366   ENSP00000453466   ENSP00000450652   ENSP00000451915   ENSP00000454156  
     ENSP00000451347   ENSP00000377719   ENSP00000452267   ENSP00000452242   ENSP00000450845  
     ENSP00000451429   ENSP00000385948   ENSP00000261970   ENSP00000339523  
    Reactome Protein details: P49768

    PSEN1 Human Recombinant Protein Products:

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    OriGene Purified Protein for PSEN1
    OriGene Protein Over-expression Lysate for PSEN1
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    Novus Biologicals PSEN1 Proteins
    Novus Biologicals PSEN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PSEN1

     
    Search eBioscience for Proteins for PSEN1 

     
    antibodies-online proteins for PSEN1 (4 products) 

     
    antibodies-online peptides for PSEN1

    PSEN1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PSEN1
    R&D Systems Antibodies for PSEN1 (Presenilin-1)
    Cell Signaling Technology (CST) Antibodies for PSEN1 
    OriGene Antibodies for PSEN1
    OriGene Custom Antibody Services for PSEN1
    Novus Biologicals PSEN1 Antibodies
    Abcam antibodies for PSEN1 (P49768, P49810)
    Cloud-Clone Corp. Antibodies for PSEN1
    ThermoFisher Antibody for PSEN1
    antibodies-online antibodies for PSEN1 (181 products) 

    PSEN1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PSEN1
    R&D Systems ELISAs for PSEN1 (Presenilin-1)         (see all)
    GenScript Custom Assay Services for PSEN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PSEN1
    Cloud-Clone Corp. CLIAs for PSEN1
    Search eBioscience for ELISAs for PSEN1 
    antibodies-online kits for PSEN1 (34 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002031 Pept_A22A_PS1
     IPR006639 Preselin/SPP
     IPR001108 Peptidase_A22A

    Graphical View of Domain Structure for InterPro Entry P49768

    ProtoNet protein and cluster: P49768

    2 Blocks protein domains:
    IPB002031 Presenilin 1 signature
    IPB006639 Presenilin signal peptide peptidase


    UniProtKB/Swiss-Prot: PSN1_HUMAN, P49768
    Domain: The PAL motif is required for normal active site conformation
    Similarity: Belongs to the peptidase A22A family


    Find genes that share domains with PSEN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSN1_HUMAN, P49768
    Function: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the
    intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor
    protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role
    in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates
    cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or
    calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the
    pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis

         Genatlas biochemistry entry for PSEN1:
    presenilin 1,forming a multimeric complex that contains catenin beta (CTNNB1) and delta (CTNND1),widely expressed
    at low levels within the CNS,predominantly in the neocortex,dentate gyrus,hippocampus,cerebellar cortex,deep
    nuclei,also expressed in other organs,predominantly located in intracellular membranous organelles such as
    nuclear envelope,endoplasmic reticulum and Golgi apparatus with two alternatively variants,spliced in exon 3
    (VRSQ) and in exon 8,but not involved in the protein transport from endoplasmic reticulum to the Golgi
    apparatus,membrane receptor for GDI1 and may be involved in the cleavage of APP and NOTCHs,interacting with Rab11
    and may be involved in APP vesicular trafficking homologous to C elegans SPE-4,putative susceptibility factor for
    early onset EOAA independent of APOE4 and for late onset AD,both associated with the -48C->T polymorphism

         Enzyme Numbers (IUBMB): EC 3.4.232 EC 3.4.23.-1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity IDA8755489
    GO:0004190aspartic-type endopeptidase activity IEA--
    GO:0005262calcium channel activity IMP16959576
    GO:0005515protein binding IPI11076969
    GO:0008013beta-catenin binding IPI11104755
         
    Find genes that share ontologies with PSEN1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PSEN1:
     Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 19 alleles(MGI details for Psen1) (see all 23):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  muscle 

    Find genes that share phenotypes with PSEN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PSEN1: Psen1tm2.1Shn Psen1tm1Zhe Psen1tm1Psgh Psen1tm1Hko Psen1tm1Pcw Psen1tm1Bdes
                                                         Psen1tm1Shn Psen1tm1Shs

       genOway: Develop your customized and physiologically relevant rodent model for PSEN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PSEN1:
    hsa-mir-562 (MIRT005025), hsa-mir-183-5p (MIRT025010), hsa-mir-155-5p (MIRT020666)

    Block miRNA regulation of human, mouse, rat PSEN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PSEN1 (see all 68):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-520e hsa-miR-193a-3p hsa-miR-520f hsa-miR-106a hsa-miR-128 hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidPSEN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PSEN1
    Predesigned siRNA for gene silencing in human, mouse, rat PSEN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PSEN1

    Clone
    Products:
         
    OriGene clones in human, mouse for PSEN1 (see all 11)
    OriGene ORF clones in mouse, rat for PSEN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PSEN1 (NM_007318)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSEN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSEN1

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PSEN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSEN1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12380) for PSEN1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PSN1_HUMAN, P49768: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane;
    Multi-pass membrane protein. Cell surface. Note=Bound to NOTCH1 also at the cell surface. Colocalizes with CDH1/2
    at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the
    plasma membrane. Also present in azurophil granules of neutrophils
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endoplasmic reticulum5
    golgi apparatus5
    nucleus5
    plasma membrane5
    lysosome3
    mitochondrion3
    vacuole3
    extracellular2
    cytosol1
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0000776kinetochore IDA9298903
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005640nuclear outer membrane IDA9246482

    Find genes that share ontologies with PSEN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PSEN1 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    Notch Signaling Pathway0.84
    Notch Signaling0.30
    2Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    3Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Development Notch Signaling Pathway0.50
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    5ErbB4 Pathway
    ErbB4 Pathway0.59


    Find genes that share SuperPaths with PSEN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for PSEN1
        A-beta Plaque Formation & APP Metabolism
    Notch Signaling Pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PSEN1
        Notch Signaling
    Molecular Mechanisms of Cancer
    Alzheimers Disease Pathway
    Presenilin-Mediated Signaling
    ErbB4 Pathway

    2 Cell Signaling Technology (CST) Pathways for PSEN1
        Wnt / Hedgehog / Notch
    Neuroscience

    1 Tocris Bioscience Pathway for PSEN1
        Notch Pathway

    3 GeneGo (Thomson Reuters) Pathways for PSEN1
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway
    Development MAG-dependent inhibition of neurite outgrowth

    Selected BioSystems Pathways for PSEN1 (see all 6)
        Notch Signaling Pathway
    Delta-Notch Signaling Pathway
    Alzheimers Disease
    Syndecan-3-mediated signaling events
    p75(NTR)-mediated signaling

    1 Reactome Pathway for PSEN1
        Degradation of the extracellular matrix


    4 Kegg Pathways  (Kegg details for PSEN1):
        Wnt signaling pathway
    Notch signaling pathway
    Neurotrophin signaling pathway
    Alzheimer's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PSEN1: 
              Stem Cell Signaling in human mouse rat
              Autophagy in human mouse rat
              Alzheimer's Disease in human mouse rat
              Apoptosis 384HT in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PSEN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PSEN1 (P497681, 2, 3 ENSP000003263664) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBA1Q024101, 2, 3, ENSP000002653814EBI-297277,EBI-368690 MINT-1889752 I2D: score=2 STRING: ENSP00000265381
    PKP4Q995692, 3, ENSP000003744094MINT-14193 MINT-14192 MINT-14194 I2D: score=5 STRING: ENSP00000374409
    APPP050671, 3, ENSP000002849814EBI-297277,EBI-77613 I2D: score=6 STRING: ENSP00000284981
    GSK3BP498412, 3, ENSP000003248064MINT-2837737 I2D: score=5 STRING: ENSP00000324806
    BCL2L1Q078172, 3, ENSP000003025644MINT-16205 I2D: score=4 STRING: ENSP00000302564
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 86):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IEA--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000186activation of MAPKK activity IEA--
    GO:0001568blood vessel development IEA--
    GO:0001708cell fate specification IEA--

    Find genes that share ontologies with PSEN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PSEN1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRK 560gamma-secretase inhibitor; attenuates amyloid plaque deposition[677772-84-8]
    JLK 6Inhibitor of gamma-secretase-mediated betaAPP processing[62252-26-0]
    L-685,458 Potent and selective gamma-secretase inhibitor[292632-98-5]
    Begacestatgamma-secretase inhibitor; lowers Abeta40 and Abeta42 levels[769169-27-9]
    DAPTgamma-secretase inhibitor[208255-80-5]

    1 HMDB Compound for PSEN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for PSEN1 gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-182 88 20 7550356 (2), 8627338 (2), 8773595 (1), 8741394 (1) (see all 7)
    chapso 54.8 4 15766262 (3), 17663636 (1)
    lactacystin 34.8 3 9562973 (1), 9886077 (1)
    glycogen 33.2 19 11104755 (3), 17389597 (3), 16814287 (2), 17360711 (2) (see all 10)
    dantrolene 32.5 2 10662826 (1), 9051814 (1)
    thapsigargin 28.3 8 10620705 (1), 19276550 (1), 9151738 (1), 12738804 (1) (see all 6)
    calcium 28.2 125 10037477 (5), 10662826 (4), 15009636 (4), 14505542 (4) (see all 46)
    aspartate 26.6 25 18393802 (2), 10593990 (2), 8931704 (1), 10521267 (1) (see all 14)
    ryanodine 24.1 5 10764737 (3), 12909083 (1), 17328689 (1)
    vitamin b12 20.1 1 15607954 (1)



    Find genes that share compounds with PSEN1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PSEN1 gene (3 alternative transcripts): 
    NM_000021.3  NM_007318.2  NM_007319.1  

    Unigene Cluster for PSEN1:

    Presenilin 1
    Hs.3260  [show with all ESTs]
    Unigene Representative Sequence: NM_000021
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000557356 ENST00000556864 ENST00000556533 ENST00000556951 ENST00000557293
    ENST00000553719 ENST00000553599 ENST00000556011 ENST00000394157(uc001xnq.4)
    ENST00000357710 ENST00000324501(uc001xnv.3 uc001xnr.3 uc010ark.3 uc001xnu.3)
    ENST00000560005 ENST00000555254 ENST00000553447 ENST00000554131 ENST00000559361
    ENST00000557037 ENST00000394164
    miRNA
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    Block miRNA regulation of human, mouse, rat PSEN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PSEN1 (see all 68):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-520e hsa-miR-193a-3p hsa-miR-520f hsa-miR-106a hsa-miR-128 hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidPSEN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PSEN1
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    OriGene clones in human, mouse for PSEN1 (see all 11)
    OriGene ORF clones in mouse, rat for PSEN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PSEN1 (NM_007318)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSEN1
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12380) for PSEN1 

    Additional mRNA sequence: 

    AF416717.1 AJ008005.1 AK094186.1 AK094256.1 AK122722.1 AK223173.1 AK303876.1 AK312531.1 
    BC002708.2 BC011729.2 L42110.1 L76517.1 U40379.1 Y12018.1 

    19 DOTS entries:

    DT.114933  DT.97795880  DT.100793809  DT.100668038  DT.100793794  DT.95374834  DT.120773705  DT.95350660 
    DT.100793796  DT.91645558  DT.120773698  DT.92456459  DT.120773592  DT.120773601  DT.91802309  DT.92417160 
    DT.92456465  DT.95192007  DT.100808531 

    Selected AceView cDNA sequences (see all 342):

    CR614220 AW069286 CA438580 AA972181 AW604271 CD171632 CB128490 BM989159 
    AI160618 AA503101 AI138436 BI753252 U40379 BX094233 AI471960 BQ440097 
    AA463468 CA310824 CB215952 CA428276 BF515834 BM825099 NM_000021 NM_007319 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PSEN1 (see all 22)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a ·
    SP1:                                            -     -     -     -     -           -                             -     -                                       
    SP2:                                            -     -     -     -     -           -                                   -                                       
    SP3:                                                  -     -     -     -           -                             -     -                                       
    SP4:                                                                                                              -     -                                       
    SP5:                                                                                                                    -                                       

    ExUns: 10b · 10c · 10d · 10e ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c
    SP1:                                            -           -           -                                             
    SP2:                                            -           -           -                                             
    SP3:                                            -           -           -                                             
    SP4:                                            -           -                                                         
    SP5:                                            -           -                                                         


    ECgene alternative splicing isoforms for PSEN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PSEN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PSEN1 Expression
    About this image


    PSEN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Cartilage (Muscoskeletal System)
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
    PSEN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PSEN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.3260

    UniProtKB/Swiss-Prot: PSN1_HUMAN, P49768
    Tissue specificity: Expressed in a wide range of tissues including various regions of the brain, liver, spleen and
    lymph nodes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PSEN1: 
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              Apoptosis 384HT in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSEN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PSEN1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Psen11 , 5 presenilin 11, 5 87.15(n)1
    92.72(a)1
      12 (38.84 cM)5
    191641  NM_008943.21  NP_032969.11 
     836885635 
    chicken
    (Gallus gallus)
    Aves PSEN11 presenilin 1 77.47(n)
    85.25(a)
      373977  NM_204163.1  NP_989494.1 
    lizard
    (Anolis carolinensis)
    Reptilia PSEN16
    presenilin 1
    79(a)
    1 ↔ 1
    1(38936864-38967567)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.12532 Xenopus laevis mRNA for presenilin-alpha, complete more 79.88(n)    D84427.1 
    zebrafish
    (Danio rerio)
    Actinopterygii psen11 presenilin 1 70.82(n)
    80.15(a)
      30221  NM_131024.1  NP_571099.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Psn3 cytoskeleton organization and
    biogenesis
    52(a)   3 77C3   --
    worm
    (Caenorhabditis elegans)
    Secernentea sel-121 , 3 Expression: all stages3
    sel-121
    51(a)3
    56.46(n)1
    54.97(a)1
      X(951181-953466)3
    1804411  NM_075774.51  NP_508175.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PS11 PS1 46.97(n)
    39.84(a)
      837391  NM_100743.3  NP_172346.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06037001 Os03g0603700 45.98(n)
    37.67(a)
      9272037  NM_001186600.1  NP_001173529.1 


    ENSEMBL Gene Tree for PSEN1 (if available)
    TreeFam Gene Tree for PSEN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PSEN1 gene
    PSEN22  
    3 SIMAP similar genes for PSEN1 using alignment to 16 protein entries:     PSN1_HUMAN (see all proteins):
    ADCY7    PSEN2    TTC7A

    Find genes that share paralogs with PSEN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PSEN1 (see all 2170)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6611,2,,4
    CAlzheimer disease 3 (AD3)4 pathogenic154675053(+) AGCCTA/GTTTCG 4 Y C mis1 ese30--------
    VAR_0256054
    Alzheimer disease 3 (AD3)4--see VAR_0256052 A E mis40--------
    VAR_0064284
    Alzheimer disease 3 (AD3)4--see VAR_0064282 H R mis40--------
    VAR_0101244
    Alzheimer disease 3 (AD3)4--see VAR_0101242 W C mis40--------
    VAR_0162204
    Alzheimer disease 3 (AD3)4--see VAR_0162202 L V mis40--------
    VAR_0064254
    Alzheimer disease 3 (AD3)4--see VAR_0064252 M I mis40--------
    VAR_0064594
    Alzheimer disease 3 (AD3)4--see VAR_0064592 A P mis40--------
    VAR_0101214
    Alzheimer disease 3 (AD3)4--see VAR_0101212 N D mis40--------
    VAR_0064494
    Alzheimer disease 3 (AD3)4--see VAR_0064492 R T mis40--------
    VAR_0064184
    Alzheimer disease 3 (AD3)4--see VAR_0064182 E D mis40--------

    HapMap Linkage Disequilibrium report for PSEN1 (73603126 - 73690399 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PSEN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507760CNV Insertion20534489
    nsv902081CNV Gain21882294

    Human Gene Mutation Database (HGMD): PSEN1
    Locus Specific Mutation Databases (LSDB): PSEN1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PSEN1
    DNA2.0 Custom Variant and Variant Library Synthesis for PSEN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104311   
    OMIM disorders: 607822  600274  172700  613694  613737  
    UniProtKB/Swiss-Prot: PSN1_HUMAN, P49768
  • Alzheimer disease 3 (AD3) [MIM:607822]: A familial early-onset form of Alzheimer disease. Alzheimer
    disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and
    deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques
    and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42
    peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase
    processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from
    APP, are also implicated in neuronal death. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Frontotemporal dementia (FTD) [MIM:600274]: A form of dementia characterized by pathologic finding of
    frontotemporal lobar degeneration, presenile dementia with behavioral changes, deterioration of cognitive
    capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes
    include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In
    most cases, protein tau deposits are found in glial cells and/or neurons. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Cardiomyopathy, dilated 1U (CMD1U) [MIM:613694]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Acne inversa, familial, 3 (ACNINV3) [MIM:613737]: A chronic relapsing inflammatory disease of the hair
    follicles characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars.
    Manifestations typically appear after puberty. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for PSEN1 (see all 23):    
    About MalaCards
    alzheimer disease, type 3, with spastic paraparesis and apraxia    psen1-related dilated cardiomyopathy    alzheimer disease, type 3, with spastic paraparesis and unusual plaques    acne inversa, familial, 3
    frontotemporal dementia    cardiomyopathy, dilated, 1u    alzheimer disease type 3    mapt-related disorders
    dementia, frontotemporal, with or without parkinsonism    pick's disease    congenital lactase deficiency    spastic paraparesis
    familial idiopathic basal ganglia calcification    semantic dementia    frontotemporal lobar degeneration with ubiquitin-positive inclusions    acne
    dementia, familial, nonspecific    alzheimer disease type 2    memory impairment    alzheimer's disease

    3 diseases from the University of Copenhagen DISEASES database for PSEN1:
    Alzheimer's disease     Amyloidosis     Brain disease

    Find genes that share disorders with PSEN1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PSEN1 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 94.3 1115 9576554 (8), 10581340 (6), 9923762 (5), 8596269 (4) (see all 99)
    early onset alzheimer disease 92.4 40 9719376 (2), 12354302 (1), 12629906 (1), 17493013 (1) (see all 27)
    senile plaques 85.6 54 11378241 (2), 9576554 (2), 17981591 (2), 9250173 (2) (see all 37)
    neurofibrillary tangles 79.5 31 11786218 (3), 9576554 (2), 9185547 (2), 10840274 (2) (see all 19)
    amyloid deposition 74.3 16 15212842 (3), 17553989 (2), 18694898 (1), 15262269 (1) (see all 9)
    late onset alzheimer disease 74.3 8 8930979 (2), 10430506 (1), 8910899 (1), 9111746 (1)
    dementia 72.6 66 9129727 (3), 17627113 (3), 17507029 (2), 16805926 (2) (see all 45)
    frontotemporal dementia 65.7 22 11973477 (2), 11997713 (2), 10442553 (2), 18314228 (2) (see all 14)
    dementia presenile 63.3 4 18583368 (1), 10720282 (1), 16930451 (1)
    neurodegenerative diseases 62.7 9 11973477 (1), 16757805 (1), 15123735 (1), 10541872 (1) (see all 9)

    GeneTests: PSEN1
    GeneReviews: PSEN1
    Genetic Association Database (GAD): PSEN1
    Human Genome Epidemiology (HuGE) Navigator: PSEN1 (59 documents)

    Export disorders for PSEN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PSEN1 gene, integrated from 10 sources (see all 1155):
    (articles sorted by number of sources associating them with PSEN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype. (PubMed id 9172170)1, 2, 4 Kwok J.B.J.... Martins R.N. (NeuroReport 1997)
    2. Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability. (PubMed id 16126725)1, 2, 9 Serban G.... Robakis N.K. (J. Biol. Chem. 2005)
    3. Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules. (PubMed id 11987239)1, 2, 9 Mirinics Z.K.... Corey S.J. (Blood Cells Mol. Dis. 2002)
    4. Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's disease. (PubMed id 11757955)1, 4, 9 Dermaut B....van Duijn C.M. (J. Neurol. 2001)
    5. No association between presenilin 1 (PS1) intronic polymorphism and sporadic Alzheimer's disease in Koreans. (PubMed id 11129109)1, 4, 9 Kim K.W....Woo J.I. (J Neural Transm 2000)
    6. A presenilin 1 mutation (Ser169Pro) associated with early-onset AD and myoclonic seizures. (PubMed id 10025789)1, 2, 9 Ezquerra M.... Oliva R. (Neurology 1999)
    7. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. (PubMed id 10545183)1, 2, 9 Steiner H.... Haass C. (Biochemistry 1999)
    8. Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population. (PubMed id 16952411)1, 4, 9 Albani D....Forloni G. (Neurobiol. Aging 2007)
    9. A mutation screening by DHPLC of PSEN1 and APP genes reveals no significant variation associated with the sporadic late-onset form of Alzheimer's disease. (PubMed id 17412506)1, 4, 9 Scacchi R....Corbo R.M. (Neurosci. Lett. 2007)
    10. A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease. (PubMed id 12925374)1, 4, 9 Ezquerra M....Oliva R. (Arch. Neurol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5663 HGNC: 9508 AceView: PSEN1 Ensembl:ENSG00000080815 euGenes: HUgn5663
    ECgene: PSEN1 Kegg: 5663 H-InvDB: PSEN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PSEN1 Pharmacogenomics, SNPs, Pathways
    Alzheimer Research Forumhttp://www.alzforum.org/res/com/mut/pre/default.asp
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PSEN1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PSEN1 gene:
    Search GeneIP for patents involving PSEN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     OriGene Custom Antibody Services for PSEN1   OriGene Custom Protein Services for PSEN1  

     
     
     Block miRNA regulation of human, mouse, rat PSEN1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PSEN1
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     QuantiFast Probe-based Assays in human, mouse, rat PSEN1 QuantiTect SYBR Green Assays in human, mouse, rat PSEN1
     PCR Arrays including human, mouse, rat PSEN1 Search Chromatin IP Primers for PSEN1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PSEN1  GeneGlobe Interaction Network for PSEN1
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     GenScript Custom Assay Services for PSEN1 GenScript Custom overexpressing Cell Line Services for PSEN1
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for PSEN1 

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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for PSEN1
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     Browse ESI BIO Cell Lines and PureStem Progenitors for PSEN1
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSEN1
     SwitchGear 3'UTR luciferase reporter plasmids for PSEN1
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSEN1
     Browse compounds at ApexBio
     Search Addgene for plasmids for PSEN1
      Search eBioscience for proteins for PSEN1
      Search eBioscience for elisas for PSEN1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PSEN1
     antibodies-online antibodies for PSEN1 (181 products)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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