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GIFtS

PSD4 Gene

protein-coding   GIFtS: 52
GCID: GC02P113914

pleckstrin and Sec7 domain containing 4
 Explore 9 diseases affiliated with
PSD4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PSD4    

Aliases
for PSD4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pleckstrin And Sec7 Domain Containing 41 2     Telomeric Of Interleukin-1 Cluster Protein2 3
EFA6B1 2 3     ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 62
TIC1 2 3     Exchange Factor For ADP-Ribosylation Factor Guanine Nucleotide Factor 6B2
Exchange Factor For ADP-Ribosylation Factor Guanine Nucleotide Factor 6 B2 3     PH And SEC7 Domain-Containing Protein 42
Exchange Factor For ARF6 B2 3     SEC7 Homolog2
Pleckstrin Homology And SEC7 Domain-Containing Protein 42 3     

External Ids:    HGNC: 190961   Entrez Gene: 235502   Ensembl: ENSG000001256377   OMIM: 6144425   UniProtKB: Q8NDX13   

Export aliases for PSD4 gene to outside databases

Previous GC identifers: GC00U916999 GC02P113647 GC02P106385


Summaries
for PSD4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PSD4_HUMAN, Q8NDX1
Function: Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement
of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling.
Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate,
phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate




Genomic Views
for PSD4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PSD4 gene promoter:
         p300   NCX/Ncx   Olf-1   C/EBPalpha   c-Ets-1   AREB6   PPAR-alpha   MZF-1   NRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PSD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q13

PSD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSD4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113914:  view genomic region     (about GC identifiers)

Start:
 113,914,902 bp from pter      End:
 113,960,814 bp from pter
Size:
 45,913 bases      Orientation:
 plus strand

Proteins
for PSD4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PSD4_HUMAN, Q8NDX1 (See protein sequence)
Recommended Name: PH and SEC7 domain-containing protein 4  
Size: 1056 amino acids; 116249 Da
Subcellular location: Cell membrane. Note=Accumulates in dynamic actin-rich membrane ruffles and microvilli-like
structures. Recruited to membranes via phosphatidylinositol phosphate-binding
Secondary accessions: A6NEG7 A8K1Y0 O95621 Q4ZG34 Q6GPH8 Q8IYP4
Alternative splicing: 2 isoforms:  Q8NDX1-1   Q8NDX1-2   

Explore the universe of human proteins at neXtProt for PSD4: NX_Q8NDX1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NDX1

    • PSD4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036587.2  
    ENSEMBL proteins: 
     ENSP00000245796   ENSP00000413997   ENSP00000386373   ENSP00000386606  

    Human Recombinant Protein Products: 
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    Novus Biologicals PSD4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PSD4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005802NOT trans-Golgi network IBA--
    GO:0005886plasma membrane IEA--
    GO:0030054cell junction IBA--


    PSD4 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for PSD4

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    Uscn ELISAs and CLIAs for PSD4

    Protein Domains /
    Families
    for PSD4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PSD4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR023394 SEC7_alpha_orthog
     IPR001605 PH_dom-spectrin-type
     IPR011993 PH_like_dom
     IPR000904 Sec7

    Graphical View of Domain Structure for InterPro Entry Q8NDX1

    ProtoNet protein and cluster: Q8NDX1

    3 Blocks protein families:
    IPB000904 SEC7-like domain
    IPB001605 Spectrin pleckstrin homology domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PSD4_HUMAN, Q8NDX1
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    Function
    for PSD4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PSD4_HUMAN, Q8NDX1
    Function: Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement
    of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling.
    Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate,
    phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PSD4
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSD4
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate PSD4:
    hsa-miR-647 hsa-miR-765 hsa-miR-1267 hsa-miR-1207-3p hsa-miR-1827 hsa-miR-3616-3p hsa-miR-660 hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmid: PSD4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSD4 (see all 7)
    OriGene shRNA RFP: PSD4
    OriGene siRNA: PSD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSD4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PSD4

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSD4 

    Cell Line
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    Search LifeMap BioReagents cell lines for PSD4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSD4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity IBA--
    GO:0005543phospholipid binding IEA--


    PSD4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for PSD4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Endocytosis
    		Endocytosis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for PSD4):
        Endocytosis


    PSD4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PSD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for PSD4 (Q8NDX13 ENSP000002457964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP9XQ930083, ENSP000003163574I2D: score=1 STRING: ENSP00000316357
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ARF6ENSP000002983164STRING: ENSP00000298316
    ARL14ENSP000003238474STRING: ENSP00000323847
    PPP2R2BENSP000003365914STRING: ENSP00000336591
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030182neuron differentiation IBA--
    GO:0032012regulation of ARF protein signal transduction IEA--


    PSD4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PSD4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PSD4

    3 HMDB Compounds for PSD4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about PSD4 

    Transcripts
    for PSD4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PSD4 gene: 
    NM_012455.2  

    Unigene Cluster for PSD4:

    Pleckstrin and Sec7 domain containing 4
    Hs.516306  [show with all ESTs]
    Unigene Representative Sequence: AB208798
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465917 ENST00000245796(uc002tjc.3 uc002tje.3) ENST00000485525
    ENST00000418251(uc002tjd.3 uc002tjf.3) ENST00000441564 ENST00000409656
    ENST00000493329 ENST00000487574 ENST00000409378 ENST00000460725(uc002tjg.3 uc010yxs.2)
    ENST00000465592 ENST00000464559(uc002tjh.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PSD4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSD4
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate PSD4:
    hsa-miR-647 hsa-miR-765 hsa-miR-1267 hsa-miR-1207-3p hsa-miR-1827 hsa-miR-3616-3p hsa-miR-660 hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmid: PSD4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSD4 (see all 7)
    OriGene shRNA RFP: PSD4
    OriGene siRNA: PSD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSD4
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PSD4 (NM_012455)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSD4 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PSD4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSD4

    Additional cDNA sequence: 

    AB208798.1 AJ459781.1 AK023421.1 AK093556.1 AK094598.1 AK290045.1 AK294268.1 BC035307.1 
    BC073151.1 U63127.1 

    18 DOTS entries:

    DT.100815340  DT.99992078  DT.100815342  DT.100027335  DT.449285  DT.91732257  DT.120937694  DT.101974737 
    DT.100705174  DT.100815344  DT.102826776  DT.120937702  DT.75104028  DT.120937675  DT.120937720  DT.97793908 
    DT.99938874  DT.75131734 

    24/184 AceView cDNA sequences (see all 184):

    BF590986 BM893895 BQ063806 AI347421 AI361715 AI796876 BM704550 CA309178 
    BQ059103 BP367349 BM988706 BM695837 BQ712302 BC073151 AA429035 CB120737 
    BM893732 BI820970 CR598168 BM967215 AI638224 BX436874 AI743684 BF589387 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PSD4 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15a · 15b ^ 16a ·
    SP1:                                            -     -                                   -                 -           -     -     -                 -         
    SP2:                                            -                                         -                 -           -     -     -                 -         
    SP3:                                                                                      -                 -           -     -     -                 -         
    SP4:                                                                                      -                 -           -     -     -                 -         
    SP5:                                                                                                                    -     -     -                 -     -   

    ExUns: 16b ^ 17a · 17b ^ 18a · 18b · 18c · 18d · 18e
    SP1:        -                                       
    SP2:        -                                       
    SP3:        -                                       
    SP4:        -                                       
    SP5:  -     -                                       


    ECgene alternative splicing isoforms for PSD4

    Expression
    for PSD4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PSD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACCCAATGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PSD4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    EyeRetinaEye
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)

    See PSD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PSD4

    SOURCE GeneReport for Unigene cluster: Hs.516306

    UniProtKB/Swiss-Prot: PSD4_HUMAN, Q8NDX1
    Tissue specificity: Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and
    peripheral blood

        SABiosciences Custom PCR Arrays for PSD4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSD4

    Orthologs
    for PSD4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PSD4 gene from 4/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARFGEF16
    		 --
    		possible ortholog
    		 Un(3250635-3254935)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1001511961 PH and SEC7 domain-containing protein 4-like 52.55(n)
    43.66(a)    		   100151196  XM_001920687.3  XP_001920722.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Efa66
    		 Efa6 pleckstrin and Sec7 domain containing
    		 16(a)
    		 1 → many
    		 3R(18413477-18434564)
    worm
    (Caenorhabditis elegans)    		 Secernentea efa-66
    		 Exchange Factor for Arf family member (efa-6)
    		 18(a)
    		 1 → many
    		 IV(12605673-12614700)


    ENSEMBL Gene Tree for PSD4 (if available)
    TreeFam Gene Tree for PSD4 (if available) 

    Paralogs
    for PSD4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PSD4 gene
    PSD32  GBF12  CYTH32  IQSEC32  CYTH22  ARFGEF22  ARFGEF12  IQSEC12  
    PSD22  PSD2  IQSEC22  CYTH42  CYTH12  FBXO82  
    2 SIMAP similar genes for PSD4 using alignment to 3 protein entries:     PSD4_HUMAN (see all proteins):
    PSD2    PSD3

    PSD4 for paralogs           About GeneDecksing



    Genomic Variants
    for PSD4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/659 NCBI SNPs in PSD4 are shown (see all 659)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1857680111,2
    		--113929810(+) CTGCCA/GGGTGC 1 -- us2k10--------
    rs456035401,2
    		C,--113929862(+) CGGGCG/AGATCA 1 -- us2k12Minor allele frequency- A:0.01NS 84
    rs349737381,2
    		C,F,--113929896(+) AGCCTC/TGCCAA 1 -- us2k14Minor allele frequency- T:0.16NS NA WA 86
    rs1905280641,2
    		--113929916(+) ACCCCA/GTCTCT 1 -- us2k10--------
    rs789009281,2
    		--113930266(+) CTGCTC/GTGTAT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs454745981,2
    		C,--113930306(+) CAAAGG/ATTTGA 1 -- us2k12Minor allele frequency- A:0.01NS 84
    rs1435392691,2
    		--113930374(+) TCTCAC/GGCTGC 1 -- us2k10--------
    rs340912201,2
    		C,F,--113930658(+) AAGACG/CAGAGT 1 -- us2k16Minor allele frequency- C:0.07NS NA CSA WA 218
    rs1834426971,2
    		--113930680(+) GGGAGA/TGGTGG 1 -- us2k10--------
    rs455609331,2
    		C,--113930840(+) AGCCAC/TGGGGA 1 -- us2k14Minor allele frequency- T:0.04NS NA EA 334

    HapMap Linkage Disequilibrium report for PSD4 (113914902 - 113960814 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PSD4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSD4
    DNA2.0 Custom Variant and Variant Library Synthesis for PSD4

    Disorders / Diseases
    for PSD4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PSD4 for disorders           About GeneDecksing

    OMIM gene information: 614442    OMIM disorders: --

    9 diseases for PSD4:    About MalaCards
    gilles de la tourette syndrome    primary open anle glaucoma    trigeminal neuralgia    demyelinating polyneuropathy
    tourette syndrome    polyneuropathy    glaucoma    breast cancer
    neuronitis


    Export disorders for PSD4 gene to outside databases

    Publications
    for PSD4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PSD4 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with PSD4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A conserved carboxy-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions. (PubMed id 12082148)1, 2, 3 Derrien V.... Chavrier P. (2002)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. (PubMed id 21458045)2 Paul P.... Neefjes J. (2011)
    6. USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly. (PubMed id 20339350)1 ThAcard D....Luton F. (2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    8. GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. (PubMed id 18084281)1 Morishige M....Sabe H. (2008)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. (PubMed id 11050434)1 Jackson T.R....Theibert A.B. (2000)

    External Searches for PSD4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PSD4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23550 HGNC: 19096 AceView: PSD4 Ensembl:ENSG00000125637 euGenes: HUgn23550
    ECgene: PSD4 Kegg: 23550 H-InvDB: PSD4

    Other Databases showing PSD4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PSD4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PSD4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PSD4 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/psd4/

    Intellectual Property
    for PSD4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PSD4 gene:
    Search GeneIP for patents involving PSD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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