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Aliases for PSD4 Gene

Aliases for PSD4 Gene

  • Pleckstrin And Sec7 Domain Containing 4 2 3
  • EFA6B 3 4 6
  • TIC 3 4 6
  • Exchange Factor For ADP-Ribosylation Factor Guanine Nucleotide Factor 6 B 3 4
  • Pleckstrin Homology And SEC7 Domain-Containing Protein 4 3 4
  • Telomeric Of Interleukin-1 Cluster Protein 3 4
  • Exchange Factor For ARF6 B 3 4
  • Exchange Factor For ADP-Ribosylation Factor Guanine Nucleotide Factor 6B 3
  • ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 6 3
  • PH And SEC7 Domain-Containing Protein 4 3
  • SEC7 Homolog 3

External Ids for PSD4 Gene

Previous GeneCards Identifiers for PSD4 Gene

  • GC00U916999
  • GC02P113647
  • GC02P113914
  • GC02P106385

Summaries for PSD4 Gene

GeneCards Summary for PSD4 Gene

PSD4 (Pleckstrin And Sec7 Domain Containing 4) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is PSD.

UniProtKB/Swiss-Prot for PSD4 Gene

  • Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSD4 Gene

Genomics for PSD4 Gene

Regulatory Elements for PSD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSD4 Gene

Start:
113,157,325 bp from pter
End:
113,209,396 bp from pter
Size:
52,072 bases
Orientation:
Plus strand

Genomic View for PSD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSD4 Gene

Proteins for PSD4 Gene

  • Protein details for PSD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDX1-PSD4_HUMAN
    Recommended name:
    PH and SEC7 domain-containing protein 4
    Protein Accession:
    Q8NDX1
    Secondary Accessions:
    • A6NEG7
    • A8K1Y0
    • O95621
    • Q4ZG34
    • Q6GPH8
    • Q8IYP4

    Protein attributes for PSD4 Gene

    Size:
    1056 amino acids
    Molecular mass:
    116249 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PSD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSD4 Gene

Proteomics data for PSD4 Gene at MOPED

Post-translational modifications for PSD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSD4 Gene

No data available for DME Specific Peptides for PSD4 Gene

Domains for PSD4 Gene

Gene Families for PSD4 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for PSD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDX1

UniProtKB/Swiss-Prot:

PSD4_HUMAN :
  • Q8NDX1
Domain:
  • Contains 1 PH domain.
  • Contains 1 SEC7 domain.
genes like me logo Genes that share domains with PSD4: view

Function for PSD4 Gene

Molecular function for PSD4 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.

Gene Ontology (GO) - Molecular Function for PSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IBA --
GO:0005543 phospholipid binding IEA --
genes like me logo Genes that share ontologies with PSD4: view

Animal Model Products

CRISPR Products

miRNA for PSD4 Gene

miRTarBase miRNAs that target PSD4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PSD4 Gene

Localization for PSD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSD4 Gene

Cell membrane. Note=Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures. Recruited to membranes via phosphatidylinositol phosphate-binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSD4 Gene COMPARTMENTS Subcellular localization image for PSD4 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for PSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 NOT trans-Golgi network IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0030054 cell junction IBA --
genes like me logo Genes that share ontologies with PSD4: view

Pathways for PSD4 Gene

SuperPathways for PSD4 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with PSD4: view

Pathways by source for PSD4 Gene

1 KEGG pathway for PSD4 Gene

Gene Ontology (GO) - Biological Process for PSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 NOT vesicle-mediated transport IBA --
GO:0030182 neuron differentiation IBA --
GO:0032012 regulation of ARF protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with PSD4: view

Compounds for PSD4 Gene

(3) HMDB Compounds for PSD4 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with PSD4: view

Transcripts for PSD4 Gene

Unigene Clusters for PSD4 Gene

Pleckstrin and Sec7 domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSD4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PSD4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSD4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: -
SP10: - - -
SP11: - -
SP12:
SP13:

ExUns: 16b ^ 17a · 17b ^ 18a · 18b · 18c · 18d · 18e
SP1: -
SP2: -
SP3: -
SP4: -
SP5: - -
SP6:
SP7: -
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PSD4 Gene

GeneLoc Exon Structure for
PSD4
ECgene alternative splicing isoforms for
PSD4

Expression for PSD4 Gene

mRNA expression in normal human tissues for PSD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSD4 Gene

This gene is overexpressed in Whole Blood (11.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSD4 Gene

SOURCE GeneReport for Unigene cluster for PSD4 Gene Hs.516306

mRNA Expression by UniProt/SwissProt for PSD4 Gene

Q8NDX1-PSD4_HUMAN
Tissue specificity: Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.
genes like me logo Genes that share expressions with PSD4: view

In Situ Assay Products

Orthologs for PSD4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSD4 35
  • 92.57 (n)
  • 91.56 (a)
PSD4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PSD4 35
  • 81.94 (n)
  • 76.75 (a)
PSD4 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSD4 35
  • 82.09 (n)
  • 76.97 (a)
PSD4 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psd4 35
  • 77.08 (n)
  • 70.98 (a)
Psd4 16
Psd4 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSD4 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSD4 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psd4 35
  • 77.19 (n)
  • 71.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Efa6 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea efa-6 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GEA1 36
  • 8 (a)
ManyToMany
GEA2 36
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for PSD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PSD4 Gene

ENSEMBL:
Gene Tree for PSD4 (if available)
TreeFam:
Gene Tree for PSD4 (if available)

Paralogs for PSD4 Gene

Paralogs for PSD4 Gene

Selected SIMAP similar genes for PSD4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PSD4: view

Variants for PSD4 Gene

Sequence variations from dbSNP and Humsavar for PSD4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9098 -- 113,202,728(-) GTCAG(C/T)CGGCA utr-variant-3-prime
rs11928 -- 113,202,588(-) TCTCC(A/G)GAACC utr-variant-3-prime
rs13717 -- 113,202,477(-) GAAGG(A/G)GTCCA utr-variant-3-prime
rs724496 -- 113,164,699(+) GGACT(A/G)GGTAC intron-variant
rs731834 -- 113,199,621(+) ATATT(A/C)ATAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSD4 Gene

Variant ID Type Subtype PubMed ID
nsv874897 CNV Loss 21882294
dgv4283n71 CNV Gain 21882294
nsv874900 CNV Loss 21882294

Relevant External Links for PSD4 Gene

HapMap Linkage Disequilibrium report
PSD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSD4 Gene

Disorders for PSD4 Gene

No disorders were found for PSD4 Gene.

No data available for UniProtKB/Swiss-Prot for PSD4 Gene

Publications for PSD4 Gene

  1. A conserved carboxy-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions. (PMID: 12082148) Derrien V. … Chavrier P. (J. Cell Sci. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. (PMID: 18084281) Morishige M. … Sabe H. (Nat. Cell Biol. 2008) 3

Products for PSD4 Gene

Sources for PSD4 Gene

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