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Aliases for PSD2 Gene

Aliases for PSD2 Gene

  • Pleckstrin And Sec7 Domain Containing 2 2 3
  • Pleckstrin Homology And SEC7 Domain-Containing Protein 2 3 4
  • PH And SEC7 Domain-Containing Protein 2 3
  • 6330404E20Rik 3
  • EC 63
  • EC 3.6.1 63
  • EFA6C 3

External Ids for PSD2 Gene

Previous GeneCards Identifiers for PSD2 Gene

  • GC00U916997
  • GC05P139155
  • GC05P134332
  • GC05P139175

Summaries for PSD2 Gene

GeneCards Summary for PSD2 Gene

PSD2 (Pleckstrin And Sec7 Domain Containing 2) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is PSD4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSD2 Gene

Genomics for PSD2 Gene

Regulatory Elements for PSD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSD2 Gene

139,795,821 bp from pter
139,844,466 bp from pter
48,646 bases
Plus strand

Genomic View for PSD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSD2 Gene

Proteins for PSD2 Gene

  • Protein details for PSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PH and SEC7 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DQD3
    • Q8N3J8

    Protein attributes for PSD2 Gene

    771 amino acids
    Molecular mass:
    84660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSD2 Gene

Proteomics data for PSD2 Gene at MOPED

Selected DME Specific Peptides for PSD2 Gene

Post-translational modifications for PSD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PSD2 Gene

Gene Families for PSD2 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for PSD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BQI7
  • Contains 1 PH domain.
  • Contains 1 SEC7 domain.
  • Belongs to the PSD family.
genes like me logo Genes that share domains with PSD2: view

Function for PSD2 Gene

Enzyme Numbers (IUBMB) for PSD2 Gene

Gene Ontology (GO) - Molecular Function for PSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IBA --
GO:0005543 phospholipid binding IEA --
genes like me logo Genes that share ontologies with PSD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PSD2 Gene

Localization for PSD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSD2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PSD2 Gene COMPARTMENTS Subcellular localization image for PSD2 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for PSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 NOT trans-Golgi network IBA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IBA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PSD2: view

Pathways for PSD2 Gene

SuperPathways for PSD2 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with PSD2: view

Pathways by source for PSD2 Gene

1 KEGG pathway for PSD2 Gene

Gene Ontology (GO) - Biological Process for PSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 NOT vesicle-mediated transport IBA --
GO:0030182 neuron differentiation IBA --
GO:0032012 regulation of ARF protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with PSD2: view

Transcripts for PSD2 Gene

mRNA/cDNA for PSD2 Gene

(65) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSD2 Gene

Pleckstrin and Sec7 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSD2 Gene

No ASD Table

Relevant External Links for PSD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSD2 Gene

mRNA expression in normal human tissues for PSD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSD2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (6.4), Brain - Putamen (basal ganglia) (5.9), Brain - Nucleus accumbens (basal ganglia) (5.5), Brain - Amygdala (5.2), and Brain - Cortex (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PSD2 Gene

SOURCE GeneReport for Unigene cluster for PSD2 Gene Hs.21963

genes like me logo Genes that share expressions with PSD2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PSD2 Gene

Orthologs for PSD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSD2 35
  • 99.74 (n)
  • 99.61 (a)
PSD2 36
  • 100 (a)
(Bos Taurus)
Mammalia PSD2 35
  • 88.63 (n)
  • 90.92 (a)
PSD2 36
  • 90 (a)
(Canis familiaris)
Mammalia PSD2 35
  • 88.85 (n)
  • 91.28 (a)
PSD2 36
  • 87 (a)
(Mus musculus)
Mammalia Psd2 35
  • 85.71 (n)
  • 88.76 (a)
Psd2 16
Psd2 36
  • 88 (a)
(Monodelphis domestica)
Mammalia PSD2 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia PSD2 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Psd2 35
  • 85.83 (n)
  • 88.79 (a)
(Gallus gallus)
Aves PSD2 35
  • 73.54 (n)
  • 79.68 (a)
PSD2 36
  • 63 (a)
(Anolis carolinensis)
Reptilia PSD2 36
  • 64 (a)
(Danio rerio)
Actinopterygii BX005008.2 36
  • 56 (a)
LOC557199 35
  • 69.18 (n)
  • 72.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta Efa6 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea efa-6 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GEA1 36
  • 7 (a)
GEA2 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for PSD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PSD2 Gene

Gene Tree for PSD2 (if available)
Gene Tree for PSD2 (if available)

Paralogs for PSD2 Gene

Paralogs for PSD2 Gene

Selected SIMAP similar genes for PSD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSD2: view

Variants for PSD2 Gene

Sequence variations from dbSNP and Humsavar for PSD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs719460 -- 139,797,097(+) GTTCT(C/T)TCATT intron-variant
rs766740 -- 139,831,439(-) AGTCA(A/G)AGAGA intron-variant
rs889018 -- 139,818,416(-) GGCCT(A/G)CACCA intron-variant
rs889019 -- 139,838,372(+) GCCAC(A/T)AGCTG intron-variant
rs976515 -- 139,814,974(-) GGGCA(A/G)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSD2 Gene

Variant ID Type Subtype PubMed ID
nsv519808 CNV Loss 19592680
nsv882942 CNV Loss 21882294
nsv882945 CNV Loss 21882294
nsv471051 CNV Gain 18288195
nsv830506 CNV Loss 17160897

Relevant External Links for PSD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSD2 Gene

Disorders for PSD2 Gene

(1) University of Copenhagen DISEASES for PSD2 Gene

genes like me logo Genes that share disorders with PSD2: view

No data available for UniProtKB/Swiss-Prot for PSD2 Gene

Publications for PSD2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for PSD2 Gene

Sources for PSD2 Gene

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