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Aliases for PSD2 Gene

Aliases for PSD2 Gene

  • Pleckstrin And Sec7 Domain Containing 2 2 3 5
  • Pleckstrin Homology And SEC7 Domain-Containing Protein 2 3 4
  • 6330404E20Rik 3
  • EC 63
  • EC 3.6.1 63
  • EFA6C 3

External Ids for PSD2 Gene

Previous GeneCards Identifiers for PSD2 Gene

  • GC00U916997
  • GC05P139155
  • GC05P134332
  • GC05P139175
  • GC05P139795

Summaries for PSD2 Gene

GeneCards Summary for PSD2 Gene

PSD2 (Pleckstrin And Sec7 Domain Containing 2) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000268465.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSD2 Gene

Genomics for PSD2 Gene

Regulatory Elements for PSD2 Gene

Enhancers for PSD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSD2 Gene

139,721,903 bp from pter
139,844,466 bp from pter
122,564 bases
Plus strand

Genomic View for PSD2 Gene

Genes around PSD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSD2 Gene

Proteins for PSD2 Gene

  • Protein details for PSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PH and SEC7 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DQD3
    • Q8N3J8

    Protein attributes for PSD2 Gene

    771 amino acids
    Molecular mass:
    84660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSD2 Gene

Proteomics data for PSD2 Gene at MOPED

Selected DME Specific Peptides for PSD2 Gene

Post-translational modifications for PSD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PSD2 Gene

Gene Families for PSD2 Gene

Suggested Antigen Peptide Sequences for PSD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Belongs to the PSD family.
  • Contains 1 PH domain.
  • Contains 1 SEC7 domain.
  • Belongs to the PSD family.
genes like me logo Genes that share domains with PSD2: view

Function for PSD2 Gene

Enzyme Numbers (IUBMB) for PSD2 Gene

Gene Ontology (GO) - Molecular Function for PSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005543 phospholipid binding IEA --
genes like me logo Genes that share ontologies with PSD2: view
genes like me logo Genes that share phenotypes with PSD2: view

Animal Model Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSD2 Gene

Localization for PSD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSD2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PSD2 Gene COMPARTMENTS Subcellular localization image for PSD2 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for PSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with PSD2: view

Pathways & Interactions for PSD2 Gene

SuperPathways for PSD2 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with PSD2: view

Pathways by source for PSD2 Gene

1 KEGG pathway for PSD2 Gene

Gene Ontology (GO) - Biological Process for PSD2 Gene


No data available for SIGNOR curated interactions for PSD2 Gene

Drugs & Compounds for PSD2 Gene

No Compound Related Data Available

Transcripts for PSD2 Gene

mRNA/cDNA for PSD2 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSD2 Gene

Pleckstrin and Sec7 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSD2 Gene

No ASD Table

Relevant External Links for PSD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSD2 Gene

mRNA expression in normal human tissues for PSD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSD2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x6.4), Brain - Putamen (basal ganglia) (x5.9), Brain - Nucleus accumbens (basal ganglia) (x5.5), Brain - Amygdala (x5.2), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for PSD2 Gene

This gene is overexpressed in Fetal Brain (46.8) and Esophagus (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSD2 Gene

SOURCE GeneReport for Unigene cluster for PSD2 Gene Hs.21963

genes like me logo Genes that share expression patterns with PSD2: view

Protein tissue co-expression partners for PSD2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PSD2 Gene

Orthologs for PSD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PSD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PSD2 35
  • 88.63 (n)
  • 90.92 (a)
PSD2 36
  • 90 (a)
(Canis familiaris)
Mammalia PSD2 35
  • 88.85 (n)
  • 91.28 (a)
PSD2 36
  • 87 (a)
(Mus musculus)
Mammalia Psd2 35
  • 85.71 (n)
  • 88.76 (a)
Psd2 16
Psd2 36
  • 88 (a)
(Pan troglodytes)
Mammalia PSD2 35
  • 99.74 (n)
  • 99.61 (a)
PSD2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Psd2 35
  • 85.83 (n)
  • 88.79 (a)
(Monodelphis domestica)
Mammalia PSD2 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia PSD2 36
  • 80 (a)
(Gallus gallus)
Aves PSD2 35
  • 73.54 (n)
  • 79.68 (a)
PSD2 36
  • 63 (a)
(Anolis carolinensis)
Reptilia PSD2 36
  • 64 (a)
(Danio rerio)
Actinopterygii LOC557199 35
  • 69.18 (n)
  • 72.18 (a)
BX005008.2 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta Efa6 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea efa-6 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GEA1 36
  • 7 (a)
GEA2 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for PSD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PSD2 Gene

Gene Tree for PSD2 (if available)
Gene Tree for PSD2 (if available)

Paralogs for PSD2 Gene

(3) SIMAP similar genes for PSD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSD2: view

Variants for PSD2 Gene

Sequence variations from dbSNP and Humsavar for PSD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34880693 - 139,809,532(-) CATTC(C/T)GGACC reference, missense
rs3797902 - 139,809,592(+) GCGAA(G/T)GGGCA reference, missense
rs35714177 - 139,817,551(-) TGCTC(C/G/T)GTCCA reference, missense
rs719460 -- 139,797,097(+) GTTCT(C/T)TCATT intron-variant
rs735795 -- 139,788,095(-) ACTGC(C/G)CGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSD2 Gene

Variant ID Type Subtype PubMed ID
nsv519808 CNV Loss 19592680
nsv882942 CNV Loss 21882294
nsv882945 CNV Loss 21882294
nsv471051 CNV Gain 18288195
nsv830506 CNV Loss 17160897

Variation tolerance for PSD2 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSD2 Gene

Disorders for PSD2 Gene

Relevant External Links for PSD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSD2 Gene

Publications for PSD2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 67
  2. Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. (PMID: 17148452) Cannavo E. … Jiricny J. (J. Biol. Chem. 2007) 3
  3. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PSD2 Gene

Sources for PSD2 Gene