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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PSD2 Gene

protein-coding GIFtS: 50
GCID: GC05P139155

pleckstrin and Sec7 domain containing 2

Explore 3 diseases affiliated with
PSD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Pleckstrin And Sec7 Domain Containing 2¹ ²		PH And SEC7 Domain-Containing Protein 2²
Pleckstrin Homology And SEC7 Domain-Containing Protein 2² ³		EC 2.5.1.6⁸
DKFZp761B0514¹		EC 3.6.1⁸
6330404E20Rik²

External Ids:	HGNC: 19092¹	Entrez Gene: 84249²	Ensembl: ENSG00000146005⁷	UniProtKB: Q9BQI7³

Export aliases for PSD2 gene to outside databases

Previous GC identifers: GC00U916997 GC05P134332

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PSD2 gene promoter:
RP58 p53 MAZR NF-kappaB GATA-2 MZF-1 NF-kappaB2 c-Myb MRF-2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PSD2 promoter sequence

Search SABiosciences Chromatin IP Primers for PSD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31.3

PSD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PSD2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P139155: view genomic region (about GC identifiers)

Start:	139,175,406 bp from pter	End:	139,224,051 bp from pter
Size:	48,646 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PSD2_HUMAN, Q9BQI7 (See protein sequence)

Recommended Name: PH and SEC7 domain-containing protein 2

Size: 771 amino acids; 84660 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Secondary accessions: D3DQD3 Q8N3J8

Explore the universe of human proteins at neXtProt for PSD2: NX_Q9BQI7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BQI7

2 DME Specific Peptides for PSD2 (Q9BQI7)

KRTPRGR

AHRLARRL

PSD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_115665.1

ENSEMBL proteins:

ENSP00000274710

Human Recombinant Protein Products for PSD2:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals PSD2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PSD2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005802	NOT trans-Golgi network	IBA	--
GO:0016021	integral to membrane	IEA	--
GO:0030054	cell junction	IBA	--
GO:0030425	dendrite	IEA	--
GO:0043025	neuronal cell body	IEA	--

PSD2 for ontologies About GeneDecksing

PSD2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for PSD2
	Search for Antibodies for PSD2 at Abcam
	Uscn Antibodies for PSD2
	ThermoFisher Antibody for PSD2

Assay Products for PSD2:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for PSD2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PSD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PSD2 for domains About GeneDecksing

5 InterPro domains/families:

IPR001849 Pleckstrin_homology

IPR023394 SEC7_alpha_orthog

IPR001605 PH_dom-spectrin-type

IPR011993 PH_like_dom

IPR000904 Sec7

Graphical View of Domain Structure for InterPro Entry Q9BQI7

ProtoNet protein and cluster: Q9BQI7

2 Blocks protein families:

IPB001605 Spectrin pleckstrin homology domain signature

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: PSD2_HUMAN, Q9BQI7

Similarity: Belongs to the PSD family

Similarity: Contains 1 PH domain

Similarity: Contains 1 SEC7 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Enzyme Numbers (IUBMB): EC 3.6.1² EC 2.5.1.6²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005086	ARF guanyl-nucleotide exchange factor activity	IBA	--
GO:0005543	phospholipid binding	IEA	--

PSD2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PSD2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSD2
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate PSD2 (see all 31):
		hsa-miR-1178 hsa-miR-4307 hsa-miR-199b-3p hsa-miR-631 hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-3129-5p hsa-miR-650

		SwitchGear 3'UTR luciferase reporter plasmid: PSD2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSD2 (see all 7) OriGene shRNA RFP: PSD2 OriGene siRNA: PSD2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSD2
		Sirion Biotech Custom design and validation of potent shRNA sequences against PSD2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PSD2
			Sirion Biotech Customized adenovirus for overexpression of PSD2 Sirion Biotech Customized adenovirus for potent knockdown of PSD2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSD2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSD2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PSD2 (NM_032289)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSD2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSD2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PSD2
		Search LifeMap BioReagents cell lines for PSD2
		Sirion Biotech Customized stable knockdown cell line services for PSD2 Sirion Biotech Customized inducible knockdown cell line services for PSD2 Sirion Biotech Customized stable overexpressing cell line services for PSD2 Sirion Biotech Customized inducible overexpressing cell line services for PSD2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSD2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Endocytosis

Endocytosis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for PSD2):

Endocytosis

PSD2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PSD2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for PSD2 (Q9BQI7³ ENSP00000274710⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PMS1	P54277³, ENSP00000406490⁴	I2D: score=1 STRING: ENSP00000406490
PMS2	P54278³, ENSP00000265849⁴	I2D: score=1 STRING: ENSP00000265849

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016192	NOT vesicle-mediated transport	IBA	--
GO:0030182	neuron differentiation	IBA	--
GO:0032012	regulation of ARF protein signal transduction	IEA	--

PSD2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PSD2
Search CenterWatch for drugs/clinical trials and news about PSD2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PSD2 gene:

NM_032289.2

Unigene Cluster for PSD2:

Pleckstrin and Sec7 domain containing 2

Hs.21963 [show with all ESTs]

Unigene Representative Sequence: AL136559

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000274710(uc003leu.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PSD2
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate PSD2 (see all 31):
		hsa-miR-1178 hsa-miR-4307 hsa-miR-199b-3p hsa-miR-631 hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-3129-5p hsa-miR-650

		SwitchGear 3'UTR luciferase reporter plasmid: PSD2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSD2 (see all 7) OriGene shRNA RFP: PSD2 OriGene siRNA: PSD2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSD2
		Sirion Biotech Custom design and validation of potent shRNA sequences against PSD2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PSD2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PSD2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PSD2 (NM_032289)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PSD2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSD2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSD2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PSD2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSD2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSD2

Additional cDNA sequence:

AL136559.1 AL834268.1 BC038233.1

2 DOTS entries:

DT.112778 DT.100666583

24/65 AceView cDNA sequences (see all 65):

F02053 BX431556 N62170 BC038233 AL136559 AI866630 AA953847 BE047813

NM_032289 AI858637 F03540 Z42535 AL834268 BE551621 Z39050 AI990006

Z42932 AI632350 N99410 BX477942 AA323272 BE672141 BM671811 CF455015

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PSD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTACTGTA

About this image

PSD2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Ventral/hypothalamic-like neurons (Generation of midbra...)

See PSD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PSD2

SOURCE GeneReport for Unigene cluster: Hs.21963

SABiosciences Custom PCR Arrays for PSD2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSD2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PSD2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSD2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSD2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSD2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PSD2 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Psd2^{1 , 5}	pleckstrin and Sec7 domain containing 2^{1, 5}	86.01(n)¹ 89.15(a)¹		18 (19.34 cM)⁵ 74002¹ NM_028707.3¹ NP_082983.3¹ 35964830⁵
chicken (Gallus gallus)	Aves	PSD2¹	pleckstrin and Sec7 domain containing 2	72.89(n) 78.69(a)		427605 XM_003642040.1 XP_003642088.1
lizard (Anolis carolinensis)	Reptilia	PSD2⁶	--	69(a)	1 ↔ 1	4(78657817-78718393)
zebrafish (Danio rerio)	Actinopterygii	LOC557199¹	PH and SEC7 domain-containing protein 2-like	64.79(n) 64.79(a)		557199 XM_680213.1 XP_685305.1
fruit fly (Drosophila melanogaster)	Insecta	Efa6⁶	Efa6 pleckstrin and Sec7 domain containing	15(a)	1 → many	3R(18413477-18434564)
worm (Caenorhabditis elegans)	Secernentea	efa-6⁶	Exchange Factor for Arf family member (efa-6)	20(a)	1 → many	IV(12605673-12614700)

ENSEMBL Gene Tree for PSD2 (if available)
TreeFam Gene Tree for PSD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PSD2 gene

PSD3² GBF1² CYTH3² IQSEC3² CYTH2² ARFGEF2² PSD4² ARFGEF1²

IQSEC1² PSD² IQSEC2² CYTH4² CYTH1² FBXO8²

3 SIMAP similar genes for PSD2 using alignment to 1 protein entry: PSD2_HUMAN:

PSD3 PSD4 PSD

PSD2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2194141^1,2	C,F,A,H	--	139173441(-)	`CAGTCC/TCCCTC`	1	--	us2k¹ trp³		15		NS EA NA WA	2208
rs200440719^1,2		--	139173441(+)	`AGGGG-/AGACTG`	1	--	us2k¹		0	--	--	--	--
rs142139731^1,2		--	139173474(+)	`GAGGAA/GGTAGG`	1	--	us2k¹		0	--	--	--	--
rs151298361^1,2		--	139173624(+)	`GCAGGA/GGGGTA`	1	--	us2k¹		0	--	--	--	--
rs73263132^1,2	C	--	139173627(+)	`GGGGGG/TTAGAA`	1	--	us2k¹		1		WA	2
rs185923234^1,2		--	139173659(+)	`AGCTCC/TCTCTG`	1	--	us2k¹		0	--	--	--	--
rs75678221^1,2	F	--	139173725(+)	`CTGCGG/ATAATG`	1	--	us2k¹		1		WA	118
rs74334466^1,2	F	--	139173795(+)	`GTGCTC/TACAGA`	1	--	us2k¹		1		EA	120
rs145880553^1,2		--	139173819(+)	`GGATCA/GTGAGC`	1	--	us2k¹		0	--	--	--	--
rs190634130^1,2		--	139173938(+)	`TGTCAA/GAGGTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PSD2 (139175406 - 139224051 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PSD2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSD2

DNA2.0 Custom Variant and Variant Library Synthesis for PSD2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PSD2 for disorders About GeneDecksing

3 diseases for PSD2: About MalaCards

demyelinating polyneuropathy polyneuropathy neuronitis

1 disease from the University of Copenhagen DISEASES database for PSD2:

Demyelinating polyneuropathy

Export disorders for PSD2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PSD2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PSD2)

Utopia: connect your pdf to the dynamic
world of online information

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. (PubMed id 17148452)¹ Cannavo E....Jiricny J. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)² Schmutz J.... Rubin E.M. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)¹ Simpson J.C.... Wiemann S. (2000)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)¹ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84249	HGNC: 19092	AceView: PSD2	Ensembl:ENSG00000146005	euGenes: HUgn84249
ECgene: PSD2	Kegg: 84249	H-InvDB: PSD2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PSD2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PSD2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PSD2 gene:
Search GeneIP for patents involving PSD2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for PSD2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PSD2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PSD2
	OriGene Protein Over-expression Lysate for PSD2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for PSD2		Browse 3'-UTR reporter clones for miRNA target validation
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	OriGene Custom Antibody Services for PSD2		OriGene Custom Protein Services for PSD2
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PSD2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PSD2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PSD2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PSD2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PSD2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PSD2

	GenScript Custom Purified and Recombinant Proteins Services for PSD2		GenScript cDNA clones with any tag delivered in your preferred vector for PSD2
	GenScript Custom Assay Services for PSD2		GenScript Custom Superior Antibodies Services for PSD2
	GenScript Custom overexpressing Cell Line Services for PSD2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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PSD2 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PSD2

	SwitchGear 3'UTR luciferase reporter plasmids for PSD2
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ThermoFisher Antibody for PSD2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PSD2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PSD2

Sirion Biotech Customized:

	stable knockdown cell line services for PSD2
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	design and validation of potent shRNA sequences against PSD2
	adenovirus for potent knockdown of PSD2
	adenovirus for overexpression of PSD2
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PSD2 gene at Home site.

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PSD2 Gene

pleckstrin and Sec7 domain containing 2

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PSD2 Gene

pleckstrin and Sec7 domain containing 2

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