V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

PSCA Gene

protein-coding   GIFtS: 57

GC08P143758
prostate stem cell antigen
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
PRO232 2
Descriptions
prostate stem cell antigen 2
External Ids
HGNC: 95001
Entrez Gene: 80002
UniProtKB: O436533
Ensembl: ENSG000001676537
Search outside databases for aliases for PSCA gene

Previous GC identifers: GC08U990071 GC08M143995 GC08P143556 GC08P143824

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PSCA:
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition
to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon,
kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is
also detected in cancers of the bladder and pancreas. This gene has a nonsynonymous nucleotide
polymorphism at its start codon. [provided by RefSeq]

UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653
Function: May be involved in the regulation of cell proliferation. Has a cell-proliferation
inhibition activity in vitro

Gene Wiki entry for PSCA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PSCA gene  

Entrez Gene cytogenetic band: 8q24.2   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.2

PSCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P143758:     (about GC identifiers)

Start:
143,758,877 bp from pter
End:
143,761,145 bp from pter
Size:
2,269 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000008.9  NT_008046.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653 (See protein sequence)
Recommended Name: Prostate stem cell antigen precursor  
Size: 123 amino acids; 12912 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: Q6UW92

REFSEQ proteins: NP_005663.1  

ENSEMBL proteins: 
ENSP00000301258 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (PSCA)
Human Recombinant Proteins from Abnova (PSCA)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS9465086
GO:0031225 anchored to membrane IEA--
About this table

Antibodies for PSCA: 
Invitrogen Antibodies for PSCA
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for PSCA
Browse R&D Systems for Antibodies
Antibodies from Abcam (PSCA), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (PSCA)
Novus Biologicals Antibodies for PSCA

Assays for PSCA: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro domains/families:
 IPR018363 CD59_antigen_CS
 IPR016054 LY6_UPA_recep-like
 IPR001526 LY6_UPAR


   GeneDecks  PSCA for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry O43653

ProtoNet protein and cluster: O43653

1 Blocks protein family: IPB001526 CD59 antigen

UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653
Similarity: Contains 1 UPAR/Ly6 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PSCA)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (PSCA)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005672

              Applied Biosystems Silencer® siRNAs for PSCA

              Sigma-Aldrich siRNA for PSCA  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for PSCA
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005672
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005672
                                 untagged cDNA clone in CMV expression vector: NM_005672 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_005672

UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653
Function: May be involved in the regulation of cell proliferation. Has a cell-proliferation
inhibition activity in vitro
Induction: Down-regulated in gastric cancer cells

Genatlas biochemistry entry for PSCA:
prostate stem cell antigen,expressed at the cell surface of the basal cell epithelium,putative stem
cell compartment of normal prostate,overexpressed in prostate carcinoma

2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Psca):

normaltumorigenesis

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/6 Interacting proteins for PSCA (ENSP000003012583) via UniProtKB, MINT, and/or STRING (see all 6 )
InteractantInteraction Details
GeneCardExternal ID(s)
HSPA4ENSP000003029613STRING (score=.84)
HLA-CENSP000003654023STRING (score=.798)
KLK3ENSP000003141513STRING (score=.738)
FOLH1ENSP000002569993STRING (score=.734)
MSLNENSP000003723133STRING (score=.728)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PSCA

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PSCA)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (PSCA)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005672

              Sigma-Aldrich siRNA for PSCA  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_005672  

REFSEQ mRNAs for PSCA gene: 

NM_005672.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_005672  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005672
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005672
                                 untagged cDNA clone in CMV expression vector: NM_005672 

Additional cDNA sequence: 

AK092432.1 CR590598.1 XM_001725898.1 

8 DOTS entries:

DT.87016486  DT.95251395  DT.120639806  DT.40109316  DT.40196070  DT.95087715  DT.97818526  DT.100743374 

24/115 AceView cDNA sequences (see all 115 ):

BC048808 BU168445 BQ876328 BM042052 BM828076 BM980194 BQ678675 BU174241 
BM817901 BM980213 BU179764 BM788964 CB850631 BQ082579 CB993163 CB996183 
BM980828 BM768967 BI763933 AW134915 AI685741 AI623123 BU194301 BU157227 

highest scoring ESTs for PSCA:

AA158880 AA446964 AA525838 AA543070 AA548812 AA630584 AA662112 AA702913 AF043498 AI017464 

Unigene Clusters for PSCA:

Prostate stem cell antigen
Hs.652235  [show with all ESTs], Hs.711174  [show with all ESTs]
Unigene Representative Sequences: BU838702, AK092432


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000301258  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PSCA expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for PSCA

1 / 2 / 3

5 probe-sets matching PSCA gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
33792_at2, 3 U95-A 2 1.00 0.97 0.97 1.02 AF043498 0.80 1.00 0.91 1
63958_at2, 3 U95-C 1 0.62 1.00 0.99 0.99 AI583077 0.60 1.00 0.82 1

205319_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005672 0.60 1.00 0.82 1

1560011_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

205319_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  PSCA for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.652235 Hs.711174

Expression variation in blood from EXPOLDB for PSCA

UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653
Tissue specificity: Highly expressed in prostate (basal, secretory and neuroendocrine epithelium
cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach
(neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed
in prostate cancers and expression is correlated with tumor stage, grade and
androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric
epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal
epithelium (at protein level)

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for PSCA gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
PSCA1   -- prostate stem cell antigen 82.38(n)
77.24(a)
482068  XM_539189.2  XP_539189.2 
chimpanzee
(Pan troglodytes)
PSCA1   -- prostate stem cell antigen 99.19(n)
99.19(a)
472876  XM_001149385.1  XP_001149385.1 
mouse
(Mus musculus)
Psca1, 5 155
prostate stem cell antigen1, 5 68.83(n)1
57.72(a)1
723731  NM_028216.11  NP_082492.11 
 AF3191735  AK0088515  (see all 6)
chicken
(Gallus gallus)
PSCA1   -- prostate stem cell antigen 53.33(n)
42.61(a)
420302  XM_418414.2  XP_418414.2 
About this table        Species with no ortholog for PSCA

ENSEMBL Gene Tree for PSCA
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for PSCA gene
LY6E2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653
Polymorphism: Genetic variations in PSCA may influence susceptibility to diffuse-type gastric
cancer


10/23 NCBI SNPs in PSCA are shown (see all 23 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 54)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 8 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs29202811,2
A,C143757446(-) AGCCCA/GCTGGG 1 -- ng510--------
--
rs117770391,2
H143757196(+) CAGCTG/AGCTGG 1 -- ng51 tfbs34Minor allele frequency- A:0.00EU EA WA 418
--
rs117846041,2
C143757143(+) GGCAGC/GAGAGC 1 -- ng510--------
--
rs29763891,2
C143757423(+) GGCCAC/TAGCCA 1 -- ng510--------
--
rs29763881,2
C143757258(+) CAGCCA/GGCTGG 1 -- ng510--------
--
rs117846071,2
H143757175(+) CTAGCC/TACTGC 1 -- ng514Minor allele frequency- T:0.00EU EA WA 418
--
rs117867191,2
C143757149(+) AGAGCC/TTGGGC 1 -- ng510--------
--
rs117867211,2
C143757181(+) ACTGCC/TACCAC 1 -- ng510--------
--
rs132742021,2
--143757168(+) GAGGGC/TCCTAG 1 -- ng510--------
--
rs132522641,2
--143757170(+) GGGTCA/CTAGCC 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for PSCA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602470

10/20 Novoseek disease relationships for PSCA gene (see all 20 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer 76.20 90 15814638 (7), 10713670 (6), 9465086 (4), 10564591 (4) (see all 30)
prostatic intraepithelial neoplasia 69.05 4 9465086 (1), 17503471 (1), 15342669 (1), 15132743 (1)
prostate carcinoma 56.23 5 11034097 (1), 16015594 (1), 11368875 (1), 15973992 (1)
pancreatic carcinoma 52.26 9 19180924 (4), 11389052 (2), 12894563 (1), 15626919 (1)
tumors 50.95 77 11406532 (6), 10713670 (5), 16015594 (5), 10973799 (4) (see all 31)
bone metastases 50.71 7 15814638 (3), 10713670 (1), 11226295 (1)
pancreatic cancer 49.95 25 16024997 (5), 17549363 (3), 16957968 (2), 11389052 (2) (see all 8)
pancreatic tumor 48.73 1 16957968 (1)
benign prostatic hyperplasia 46.43 3 11034097 (1), 15342669 (1), 15132743 (1)
adenocarcinoma 45.13 12 12966350 (2), 11238029 (2), 15626919 (2), 15696124 (1) (see all 8)
About this table

Human Gene Mutation Database: PSCA
Human Genome Epidemiology Navigator: PSCA (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/81 PubMed articles for PSCA gene (see all 81 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8000 HGNC: 9500 AceView: PSCA Ensembl:ENSG00000167653 euGenes: HUgn8000
ECgene: PSCA H-InvDB: PSCA
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for PSCA Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for PSCA:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for PSCA-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for PSCA Antibodies for PSCA
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (PSCA)
 Antibodies (PSCA)
 Chimera RNAi (PSCA)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(PSCA)
 Antibodies (PSCA)
 Search OriGene for PSCA
 Search Tocris compounds for PSCA




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for PSCA

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PSCA Gene at Home site.
Version 2.41.1
server4.xennexinc.com