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Aliases & Descriptions for PSCA
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| prostate stem cell antigen 2 |
|
| | Search outside databases for aliases for PSCA genePrevious GC identifers: GC08U990071 GC08M143995 GC08P143556 GC08P143824 |
Summaries for PSCA(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PSCA: This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene has a nonsynonymous nucleotide polymorphism at its start codon. [provided by RefSeq] UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653Function: May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitroGene Wiki entry for PSCA |
Genomic Location for PSCA
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PSCA gene 
Entrez Gene cytogenetic band: 8q24.2 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.2PSCA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P143758:
(about GC identifiers)
Start:
|
143,758,877 bp from pter |
End:
|
143,761,145 bp from pter |
Size:
|
2,269 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008046.15
| Proteins for PSCA
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653 (See
protein sequence)Recommended Name: Prostate stem cell antigen precursor Size: 123 amino acids; 12912 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: Q6UW92REFSEQ proteins: NP_005663.1
ENSEMBL proteins: ENSP00000301258
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for PSCA: Assays for PSCA: | Protein
Domains/ Families for PSCA(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O43653
ProtoNet protein and cluster: O43653 1 Blocks protein family: IPB001526 CD59 antigen
UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653Similarity: Contains 1 UPAR/Ly6 domain | Gene Function for PSCA
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005672
Applied Biosystems Silencer® siRNAs for PSCA
Sigma-Aldrich siRNA for PSCA  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005672                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005672                                  untagged cDNA clone in CMV expression vector: NM_005672 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005672
UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653Function: May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitroInduction: Down-regulated in gastric cancer cellsGenatlas biochemistry entry for PSCA:prostate stem cell antigen,expressed at the cell surface of the basal cell epithelium,putative stem cell compartment of normal prostate,overexpressed in prostate carcinoma2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Psca):
| Pathways & Interactions for PSCA
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/6 Interacting proteins for PSCA (ENSP000003012583) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
|
Drugs & Compounds for PSCA(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PSCA
|
Transcripts for PSCA(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005672
Sigma-Aldrich siRNA for PSCA  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005672 REFSEQ mRNAs for PSCA gene: NM_005672.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005672               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005672                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005672                                  untagged cDNA clone in CMV expression vector: NM_005672  Additional cDNA sequence: AK092432.1 CR590598.1 XM_001725898.1 8 DOTS entries: DT.87016486 DT.95251395 DT.120639806 DT.40109316 DT.40196070 DT.95087715 DT.97818526 DT.100743374 24/115 AceView cDNA sequences (see all 115
):BC048808 BU168445 BQ876328 BM042052 BM828076 BM980194 BQ678675 BU174241 BM817901 BM980213 BU179764 BM788964 CB850631 BQ082579 CB993163 CB996183 BM980828 BM768967 BI763933 AW134915 AI685741 AI623123 BU194301 BU157227
highest scoring ESTs for PSCA:AA158880 AA446964 AA525838 AA543070 AA548812 AA630584 AA662112 AA702913 AF043498 AI017464 Unigene Clusters for PSCA: Prostate stem cell antigen Hs.652235 [show with all ESTs], Hs.711174 [show with all ESTs]Unigene Representative Sequences: BU838702, AK092432
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000301258
|
Expression for PSCA
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PSCA expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PSCA
1 / 2 / 3 5 probe-sets matching PSCA gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.652235 Hs.711174
Expression variation in blood from EXPOLDB for PSCA UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653Tissue specificity: Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level) |
Orthologs for PSCA
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PSCA gene from 4 species
About this table Species with no ortholog for PSCA
ENSEMBL Gene Tree for PSCA | Paralogs for PSCA(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PSCA gene
- LY6E2
|
SNPs/Variants for PSCA(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: PSCA_HUMAN, O43653Polymorphism: Genetic variations in PSCA may influence susceptibility to diffuse-type gastric cancer
HapMap Linkage Disequilibrium images for PSCA (up to first 250kb)
|
Disorders & Mutations for PSCA
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602470
10/20 Novoseek disease relationships for PSCA gene (see all 20
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| prostate cancer |
76.20 |
90 |
15814638 (7), 10713670 (6), 9465086 (4), 10564591 (4) (see all 30) |
| prostatic intraepithelial neoplasia |
69.05 |
4 |
9465086 (1), 17503471 (1), 15342669 (1), 15132743 (1) |
| prostate carcinoma |
56.23 |
5 |
11034097 (1), 16015594 (1), 11368875 (1), 15973992 (1) |
| pancreatic carcinoma |
52.26 |
9 |
19180924 (4), 11389052 (2), 12894563 (1), 15626919 (1) |
| tumors |
50.95 |
77 |
11406532 (6), 10713670 (5), 16015594 (5), 10973799 (4) (see all 31) |
| bone metastases |
50.71 |
7 |
15814638 (3), 10713670 (1), 11226295 (1) |
| pancreatic cancer |
49.95 |
25 |
16024997 (5), 17549363 (3), 16957968 (2), 11389052 (2) (see all 8) |
| pancreatic tumor |
48.73 |
1 |
16957968 (1) |
| benign prostatic hyperplasia |
46.43 |
3 |
11034097 (1), 15342669 (1), 15132743 (1) |
| adenocarcinoma |
45.13 |
12 |
12966350 (2), 11238029 (2), 15626919 (2), 15696124 (1) (see all 8) |
About this table
Human Gene Mutation Database: PSCA Human Genome Epidemiology Navigator: PSCA (1 document)
|
Medical News for PSCA(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PSCA (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/81 PubMed articles for PSCA gene (see all 81
):- Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. (PubMed id 9465086)1, 2, 3, 4 Reiter R.E.... Witte O.N. (1998)
- Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer. (PubMed id 10713670)1, 3, 4 Gu Z.... Reiter R.E. (2000)
- Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors. (PubMed id 10973799)1, 3, 4 Bahrenberg G.... Jakse G. (2000)
- Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. (PubMed id 18488030)1, 3, 4 ....Hirohashi S. (2008)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)3, 4 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- Complete androgen ablation suppresses prostate stem cell antigen (PSCA) mRNA expression in human prostate carcinoma. (PubMed id 16015594)1, 3 Zhigang Z. and Wenlu S. (2005)
- Prostate stem cell antigen is overexpressed in prostate cancer metastases. (PubMed id 15814638)1, 3 Lam J.S....Reiter R.E. (2005)
- Prostate stem cell antigen is overexpressed in human transitional cell carcinoma. (PubMed id 11406532)1, 3 Amara N....Reiter R.E. (2001)
|
Search for PSCA
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PSCA
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PSCA
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PSCA(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PSCA(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PSCA:

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