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Aliases for PSAPL1 Gene

Aliases for PSAPL1 Gene

  • Prosaposin-Like 1 (Gene/Pseudogene) 2 3
  • Prosaposin-Like 1 2

External Ids for PSAPL1 Gene

Previous GeneCards Identifiers for PSAPL1 Gene

  • GC04M007485
  • GC04M007357

Summaries for PSAPL1 Gene

GeneCards Summary for PSAPL1 Gene

PSAPL1 (Prosaposin-Like 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Lysosome. An important paralog of this gene is PSAP.

UniProtKB/Swiss-Prot for PSAPL1 Gene

  • May activate the lysosomal degradation of sphingolipids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSAPL1 Gene

Genomics for PSAPL1 Gene

Regulatory Elements for PSAPL1 Gene

Genomic Location for PSAPL1 Gene

7,430,294 bp from pter
7,434,973 bp from pter
4,680 bases
Minus strand

Genomic View for PSAPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSAPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSAPL1 Gene

Proteins for PSAPL1 Gene

  • Protein details for PSAPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proactivator polypeptide-like 1
    Protein Accession:
    Secondary Accessions:
    • A0A184
    • Q8N7T4

    Protein attributes for PSAPL1 Gene

    521 amino acids
    Molecular mass:
    56627 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH68579.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05143.1; Type=Erroneous termination; Positions=510; Note=Translated as Trp.; Evidence={ECO:0000305};

neXtProt entry for PSAPL1 Gene

Proteomics data for PSAPL1 Gene at MOPED

Post-translational modifications for PSAPL1 Gene

  • Glycosylation at Asn201 and Asn311
  • Modification sites at PhosphoSitePlus

Other Protein References for PSAPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSAPL1 Gene

Domains for PSAPL1 Gene

Protein Domains for PSAPL1 Gene

Suggested Antigen Peptide Sequences for PSAPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 saposin A-type domains.
  • Contains 2 saposin A-type domains.
  • Contains 4 saposin B-type domains.
genes like me logo Genes that share domains with PSAPL1: view

No data available for Gene Families for PSAPL1 Gene

Function for PSAPL1 Gene

Molecular function for PSAPL1 Gene

UniProtKB/Swiss-Prot Function:
May activate the lysosomal degradation of sphingolipids.

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSAPL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PSAPL1 Gene

Localization for PSAPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSAPL1 Gene


Subcellular locations from

Jensen Localization Image for PSAPL1 Gene COMPARTMENTS Subcellular localization image for PSAPL1 gene
Compartment Confidence
extracellular 3
lysosome 2
vacuole 2

Gene Ontology (GO) - Cellular Components for PSAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA --
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with PSAPL1: view

Pathways for PSAPL1 Gene

SuperPathways for PSAPL1 Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with PSAPL1: view

Pathways by source for PSAPL1 Gene

1 KEGG pathway for PSAPL1 Gene

Interacting Proteins for PSAPL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000317445 for PSAPL1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PSAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006665 sphingolipid metabolic process IEA --
genes like me logo Genes that share ontologies with PSAPL1: view

Transcripts for PSAPL1 Gene

mRNA/cDNA for PSAPL1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSAPL1 Gene

Prosaposin-like 1 (gene/pseudogene):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSAPL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSAPL1 Gene

No ASD Table

Relevant External Links for PSAPL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSAPL1 Gene

mRNA expression in normal human tissues for PSAPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSAPL1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (25.9) and Skin - Not Sun Exposed (Suprapubic) (22.0).

Protein differential expression in normal tissues for PSAPL1 Gene

This gene is overexpressed in Skin (65.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PSAPL1 Gene

SOURCE GeneReport for Unigene cluster for PSAPL1 Gene Hs.662523

genes like me logo Genes that share expressions with PSAPL1: view

Expression partners for PSAPL1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PSAPL1 Gene

Orthologs for PSAPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PSAPL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PSAPL1 35
  • 73.54 (n)
  • 59.72 (a)
  • 56 (a)
(Mus musculus)
Mammalia Psapl1 35
  • 73.96 (n)
  • 67.47 (a)
Psapl1 16
Psapl1 36
  • 63 (a)
(Pan troglodytes)
Mammalia PSAPL1 35
  • 98.66 (n)
  • 98.66 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Psapl1 35
  • 75.08 (n)
  • 68.34 (a)
(Canis familiaris)
Mammalia PSAPL1 36
  • 37 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
-- 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
(Gallus gallus)
Aves -- 36
  • 31 (a)
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
(Danio rerio)
Actinopterygii psap 36
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sap-r 36
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
Species with no ortholog for PSAPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSAPL1 Gene

Gene Tree for PSAPL1 (if available)
Gene Tree for PSAPL1 (if available)

Paralogs for PSAPL1 Gene

Paralogs for PSAPL1 Gene

(1) SIMAP similar genes for PSAPL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSAPL1: view

Variants for PSAPL1 Gene

Sequence variations from dbSNP and Humsavar for PSAPL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_051895 -
VAR_051896 -
VAR_061780 -
VAR_061781 -
VAR_061782 -

Structural Variations from Database of Genomic Variants (DGV) for PSAPL1 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv508994 CNV Insertion 20534489
nsv469758 CNV Complex 16826518
nsv878560 CNV Gain 21882294
dgv5447n71 CNV Loss 21882294
nsv878562 CNV Loss 21882294
nsv878565 CNV Loss 21882294
nsv470008 CNV Loss 18288195
nsv461203 CNV Loss 19166990
nsv461204 CNV Loss 19166990
nsv461205 CNV Loss 19166990

Relevant External Links for PSAPL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSAPL1 Gene

Disorders for PSAPL1 Gene

No disorders were found for PSAPL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PSAPL1 Gene

Publications for PSAPL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PSAPL1 Gene

Sources for PSAPL1 Gene

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