Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRUNE2 Gene

Aliases for PRUNE2 Gene

  • Prune Homolog 2 2 3 5
  • KIAA0367 2 3 4
  • BNIP2 Motif-Containing Molecule At The C-Terminal Region 1 3 4
  • Olfaxin 2 3
  • C9orf65 3 4
  • BNIPXL 3 4
  • BMCC1 3 4
  • BNIP2 Motif Containing Molecule At The Carboxyl Terminal Region 1 3
  • BCH Motif-Containing Molecule At The Carboxyl Terminal Region 1 3
  • Chromosome 9 Open Reading Frame 65 2
  • Prune Homolog 2 (Drosophila) 2
  • Protein Prune Homolog 2 3
  • Truncated PRUNE2 3

External Ids for PRUNE2 Gene

Previous HGNC Symbols for PRUNE2 Gene

  • C9orf65
  • KIAA0367

Previous GeneCards Identifiers for PRUNE2 Gene

  • GC09M078594
  • GC09M078627
  • GC09M079226
  • GC09M049055

Summaries for PRUNE2 Gene

Entrez Gene Summary for PRUNE2 Gene

  • The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for PRUNE2 Gene

PRUNE2 (Prune Homolog 2) is a Protein Coding gene. Diseases associated with PRUNE2 include Prostate Cancer. GO annotations related to this gene include pyrophosphatase activity. An important paralog of this gene is ATCAY.

UniProtKB/Swiss-Prot for PRUNE2 Gene

  • May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.

Gene Wiki entry for PRUNE2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRUNE2 Gene

Genomics for PRUNE2 Gene

Regulatory Elements for PRUNE2 Gene

Enhancers for PRUNE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F076687 1.4 FANTOM5 Ensembl ENCODE 67.6 +217.5 217452 3.5 RARA ZNF121 MIXL1 THAP11 CEBPB PPARG KAT8 CEBPA ETV4 SOX13 PRUNE2 GCNT1 GC09P076757 LOC105376095
GH09F076704 0.9 Ensembl ENCODE 93.7 +201.4 201431 0.5 CTCF ZNF654 STAT1 MAFG REST RAD21 SREBF1 FOXK2 STAT3 SMC3 PRUNE2 GC09P076757 LOC105376095
GH09F076699 0.7 Ensembl ENCODE 95.1 +205.1 205058 2.7 PKNOX1 JUND POLR2A PRUNE2 GC09P076757 LOC105376095
GH09F076691 0.7 ENCODE 75.5 +213.9 213934 1.7 ZNF263 MAZ L3MBTL2 TEAD4 ZNF76 ZFP69B ZNF366 PATZ1 ZBTB20 TRIM28 PRUNE2 GC09P076757 LOC105376095
GH09F076642 1.1 Ensembl ENCODE 25 +262.8 262820 2.4 FEZF1 ZNF2 ZEB1 GLIS2 ZNF366 SCRT2 EGR2 ZNF263 TSHZ1 ZNF843 PRUNE2 LOC105376095 GC09P076757
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRUNE2 on UCSC Golden Path with GeneCards custom track

Promoters for PRUNE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001306142 619 2799 INSM2 ZNF76 KLF17 SIN3A FEZF1 GLIS2 ELK1 EGR2 ZNF263 MIER2

Genomic Location for PRUNE2 Gene

Chromosome:
9
Start:
76,611,376 bp from pter
End:
76,906,220 bp from pter
Size:
294,845 bases
Orientation:
Minus strand

Genomic View for PRUNE2 Gene

Genes around PRUNE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRUNE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRUNE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRUNE2 Gene

Proteins for PRUNE2 Gene

  • Protein details for PRUNE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUY3-PRUN2_HUMAN
    Recommended name:
    Protein prune homolog 2
    Protein Accession:
    Q8WUY3
    Secondary Accessions:
    • B3KYC4
    • B4DQH8
    • O15073
    • Q58A63
    • Q5JUB6
    • Q5T304
    • Q5T476
    • Q6T2V6
    • Q6T2V7
    • Q8N665

    Protein attributes for PRUNE2 Gene

    Size:
    3088 amino acids
    Molecular mass:
    340635 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • PRUNE2/BMCC1 and PCA3, one of the most prostate cancer specific markers are overlapping genes in reverse orientation. However, they do not appear to be coregulated.
    SequenceCaution:
    • Sequence=AAH22571.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22571.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAR15150.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAR15151.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD93351.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI10915.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16084.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39750.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PRUNE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRUNE2 Gene

Post-translational modifications for PRUNE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRUNE2 Gene

Domains & Families for PRUNE2 Gene

Gene Families for PRUNE2 Gene

Protein Domains for PRUNE2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUY3

UniProtKB/Swiss-Prot:

PRUN2_HUMAN :
  • Contains 1 CRAL-TRIO domain.
  • Belongs to the PPase class C family. Prune subfamily.
Domain:
  • Contains 1 CRAL-TRIO domain.
Family:
  • Belongs to the PPase class C family. Prune subfamily.
genes like me logo Genes that share domains with PRUNE2: view

Function for PRUNE2 Gene

Molecular function for PRUNE2 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.
UniProtKB/Swiss-Prot Induction:
Down-regulated after NGF-induced differentiation, and up-regulated during the NGF-depletion-induced apoptosis.

Gene Ontology (GO) - Molecular Function for PRUNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016462 pyrophosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRUNE2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRUNE2 Gene

Localization for PRUNE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRUNE2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRUNE2 gene
Compartment Confidence
nucleus 3
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for PRUNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRUNE2: view

Pathways & Interactions for PRUNE2 Gene

SuperPathways for PRUNE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRUNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA,IBA --
genes like me logo Genes that share ontologies with PRUNE2: view

No data available for Pathways by source and SIGNOR curated interactions for PRUNE2 Gene

Transcripts for PRUNE2 Gene

mRNA/cDNA for PRUNE2 Gene

Unigene Clusters for PRUNE2 Gene

Prune homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRUNE2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
SP1: - -
SP2: - - - - -
SP3: - -
SP4:
SP5: - - - -
SP6: - -
SP7:
SP8: -
SP9: - - -
SP10:

Relevant External Links for PRUNE2 Gene

GeneLoc Exon Structure for
PRUNE2
ECgene alternative splicing isoforms for
PRUNE2

Expression for PRUNE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRUNE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRUNE2 Gene

This gene is overexpressed in Esophagus - Muscularis (x4.5).

Protein differential expression in normal tissues from HIPED for PRUNE2 Gene

This gene is overexpressed in Testis (40.1) and Urinary Bladder (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRUNE2 Gene



NURSA nuclear receptor signaling pathways regulating expression of PRUNE2 Gene:

PRUNE2

SOURCE GeneReport for Unigene cluster for PRUNE2 Gene:

Hs.262857

mRNA Expression by UniProt/SwissProt for PRUNE2 Gene:

Q8WUY3-PRUN2_HUMAN
Tissue specificity: A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. Expression is significantly higher in favorable tumors than aggressive ones.
genes like me logo Genes that share expression patterns with PRUNE2: view

Primer Products

No data available for Protein tissue co-expression partners for PRUNE2 Gene

Orthologs for PRUNE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRUNE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRUNE2 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia PRUNE2 34 35
  • 83.76 (n)
cow
(Bos Taurus)
Mammalia PRUNE2 34 35
  • 82.53 (n)
mouse
(Mus musculus)
Mammalia Prune2 34 16 35
  • 77.04 (n)
rat
(Rattus norvegicus)
Mammalia Prune2 34
  • 76.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRUNE2 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRUNE2 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRUNE2 35
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRUNE2 35
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii prune2 35
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11593 35
  • 33 (a)
OneToMany
Species where no ortholog for PRUNE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRUNE2 Gene

ENSEMBL:
Gene Tree for PRUNE2 (if available)
TreeFam:
Gene Tree for PRUNE2 (if available)

Paralogs for PRUNE2 Gene

Paralogs for PRUNE2 Gene

genes like me logo Genes that share paralogs with PRUNE2: view

Variants for PRUNE2 Gene

Sequence variations from dbSNP and Humsavar for PRUNE2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10046811 -- 76,635,233(+) tccca(A/G)actgc intron-variant
rs10113868 -- 76,786,739(+) ATTGC(C/T)TTAGA intron-variant, nc-transcript-variant
rs10113882 -- 76,866,674(+) AAGTA(C/T)AAAAa intron-variant
rs10113999 -- 76,757,063(+) GCTAA(C/T)GGATT intron-variant
rs10114251 -- 76,818,432(+) AAAAC(A/G)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRUNE2 Gene

Variant ID Type Subtype PubMed ID
nsv8526 CNV loss 18304495
nsv824952 CNV loss 20364138
nsv6571 CNV insertion 18451855
nsv527438 CNV gain 19592680
nsv510193 OTHER sequence alteration 20534489
nsv1147298 CNV duplication 26484159
nsv1141000 CNV deletion 24896259
nsv1054381 CNV loss 25217958
nsv1040363 CNV gain 25217958
esv5447 CNV gain 19470904
esv4747 CNV loss 18987735
esv3620752 CNV loss 21293372
esv3620751 CNV loss 21293372
esv3620750 CNV loss 21293372
esv3620746 CNV loss 21293372
esv3441383 CNV insertion 20981092
esv3439544 CNV insertion 20981092
esv3390142 CNV insertion 20981092
esv3345565 CNV insertion 20981092
esv3308196 CNV mobile element insertion 20981092
esv3307144 CNV mobile element insertion 20981092
esv3303407 CNV mobile element insertion 20981092
esv2759697 CNV loss 17122850
esv2738603 CNV deletion 23290073
esv2738602 CNV deletion 23290073
esv2738601 CNV deletion 23290073
esv2670071 CNV deletion 23128226
esv2663601 CNV deletion 23128226
dgv1484e214 CNV gain 21293372

Variation tolerance for PRUNE2 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.38; 99.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRUNE2 Gene

Human Gene Mutation Database (HGMD)
PRUNE2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRUNE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRUNE2 Gene

Disorders for PRUNE2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRUNE2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRUNE2

Genetic Association Database (GAD)
PRUNE2
Human Genome Epidemiology (HuGE) Navigator
PRUNE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRUNE2
genes like me logo Genes that share disorders with PRUNE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRUNE2 Gene

Publications for PRUNE2 Gene

  1. Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas. (PMID: 16288218) Machida T. … Nakagawara A. (Oncogene 2006) 2 3 4 64
  2. Differential expression of PCA3 and its overlapping PRUNE2 transcript in prostate cancer. (PMID: 19760627) Salagierski M. … Schalken J.A. (Prostate 2010) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  5. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin S.G. … Macciardi F. (PLoS ONE 2009) 3 46 64

Products for PRUNE2 Gene

Sources for PRUNE2 Gene

Content
Loading form....