Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRUNE1 Gene

Aliases for PRUNE1 Gene

  • Prune Exopolyphosphatase 1 2 3 5
  • Drosophila-Related Expressed Sequence 17 3 4
  • Protein Prune Homolog 1 3 4
  • DRES-17 3 4
  • HTCD37 3 4
  • DRES17 3 4
  • PRUNE 3 4
  • Prune Homolog (Drosophila) 2
  • Exopolyphosphatase PRUNE1 3
  • Protein Prune Homolog 3
  • EC 3.6.1.1 4
  • H-PRUNE 3
  • NMIHBA 3
  • HPrune 4

External Ids for PRUNE1 Gene

Previous HGNC Symbols for PRUNE1 Gene

  • PRUNE

Summaries for PRUNE1 Gene

Entrez Gene Summary for PRUNE1 Gene

  • This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for PRUNE1 Gene

PRUNE1 (Prune Exopolyphosphatase 1) is a Protein Coding gene. Diseases associated with PRUNE1 include Neurodevelopmental Disorder With Microcephaly, Hypotonia, And Variable Brain Anomalies and Nerve Compression Syndrome. Among its related pathways are Pyrimidine metabolism (KEGG).

UniProtKB/Swiss-Prot for PRUNE1 Gene

  • Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.

Additional gene information for PRUNE1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRUNE1 Gene

Genomics for PRUNE1 Gene

Regulatory Elements for PRUNE1 Gene

Enhancers for PRUNE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H151835 1.9 FANTOM5 Ensembl ENCODE dbSUPER 25.1 +829.7 829729 6 HDGF PKNOX1 ARID4B SIN3A BRCA1 ZNF2 ZBTB7B ETS1 ELK1 ZNF207 SETDB1 PIP5K1A ARNT POGZ PI4KB GABPB2 MRPL9 PRUNE1 C1orf56 LYSMD1
GH01H151193 2 FANTOM5 Ensembl ENCODE dbSUPER 23.6 +189.3 189256 7.7 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143 ZNF687 PIP5K1A SETDB1 ARNT PI4KB PRPF3 GOLPH3L UBE2D3P3 PRUNE1 SCNM1
GH01H150557 1.7 Ensembl ENCODE dbSUPER 22.3 -439.1 -439087 23.1 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SSRP1 ZNF610 SETDB1 PIP5K1A HORMAD1 GOLPH3L PI4KB ARNT GABPB2 RPRD2 SF3B4 PRPF3
GH01H151142 1.3 ENCODE dbSUPER 25.3 +136.8 136818 6.1 HDGF PKNOX1 ATF1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 BNIPL PRUNE1 PIP5K1A C1orf56 GABPB2 SEMA6C TMOD4 ARNT VPS72 RNU6-884P
GH01H151280 1.4 ENCODE dbSUPER 22.3 +274.2 274197 3.8 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 PIP5K1A SETDB1 ARNT GOLPH3L ZNF687 PRPF3 MRPL9 GABPB2 PI4KB UBE2D3P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRUNE1 on UCSC Golden Path with GeneCards custom track

Promoters for PRUNE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000254393 409 1201 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YY1 ZNF302 ZNF207

Genomic Locations for PRUNE1 Gene

Genomic Locations for PRUNE1 Gene
chr1:151,008,391-151,035,713
(GRCh38/hg38)
Size:
27,323 bases
Orientation:
Plus strand
chr1:150,980,896-151,008,189
(GRCh37/hg19)

Genomic View for PRUNE1 Gene

Genes around PRUNE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRUNE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRUNE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRUNE1 Gene

Proteins for PRUNE1 Gene

  • Protein details for PRUNE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TP1-PRUN1_HUMAN
    Recommended name:
    Exopolyphosphatase PRUNE1
    Protein Accession:
    Q86TP1
    Secondary Accessions:
    • B2RCH8
    • B4DFL7
    • Q5SZF9
    • Q659E5
    • Q6P4E0
    • Q8N654
    • Q96JU5
    • Q9C071
    • Q9C072
    • Q9UIV0

    Protein attributes for PRUNE1 Gene

    Size:
    453 amino acids
    Molecular mass:
    50200 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homooligomer. Able to homodimerize via its C-terminal domain. Interacts with NME1. Interacts with GSK3; at focal adhesion complexes where paxillin and vinculin are colocalized.
    SequenceCaution:
    • Sequence=BAB55423.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG60534.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PRUNE1 Gene

neXtProt entry for PRUNE1 Gene

Post-translational modifications for PRUNE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRUNE1 Gene

Domains & Families for PRUNE1 Gene

Gene Families for PRUNE1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRUNE1 Gene

Suggested Antigen Peptide Sequences for PRUNE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TP1

UniProtKB/Swiss-Prot:

PRUN1_HUMAN :
  • Belongs to the PPase class C family. Prune subfamily.
Family:
  • Belongs to the PPase class C family. Prune subfamily.
genes like me logo Genes that share domains with PRUNE1: view

Function for PRUNE1 Gene

Molecular function for PRUNE1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.91 uM for cAMP {ECO:0000269 PubMed:14998490, ECO:0000269 PubMed:17655525}; KM=2.3 uM for cGMP {ECO:0000269 PubMed:14998490, ECO:0000269 PubMed:17655525}; Vmax=12.8 pmol/min/ug enzyme with cAMP as substrate {ECO:0000269 PubMed:14998490, ECO:0000269 PubMed:17655525}; Vmax=0.8 pmol/min/ug enzyme with cGMP as substrate {ECO:0000269 PubMed:14998490, ECO:0000269 PubMed:17655525};
UniProtKB/Swiss-Prot CatalyticActivity:
Diphosphate + H(2)O = 2 phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by magnesium ions and inhibited by manganese ions. Inhibited by dipyridamole, moderately sensitive to IBMX and inhibited by vinpocetine.
UniProtKB/Swiss-Prot Function:
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.

Enzyme Numbers (IUBMB) for PRUNE1 Gene

Phenotypes From GWAS Catalog for PRUNE1 Gene

Gene Ontology (GO) - Molecular Function for PRUNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004427 inorganic diphosphatase activity IEA --
GO:0005515 protein binding IPI 10602478
GO:0015631 tubulin binding IDA 28334956
GO:0016462 pyrophosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRUNE1: view
genes like me logo Genes that share phenotypes with PRUNE1: view

Animal Models for PRUNE1 Gene

MGI Knock Outs for PRUNE1:

Animal Model Products

CRISPR Products

miRNA for PRUNE1 Gene

miRTarBase miRNAs that target PRUNE1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRUNE1 Gene

Localization for PRUNE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRUNE1 Gene

Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRUNE1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRUNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005925 focal adhesion IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with PRUNE1: view

Pathways & Interactions for PRUNE1 Gene

SuperPathways for PRUNE1 Gene

SuperPathway Contained pathways
1 Pyrimidine metabolism (KEGG)
genes like me logo Genes that share pathways with PRUNE1: view

Pathways by source for PRUNE1 Gene

1 KEGG pathway for PRUNE1 Gene

Gene Ontology (GO) - Biological Process for PRUNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
GO:0031113 regulation of microtubule polymerization IMP 28334956
GO:0050767 regulation of neurogenesis IMP 28334956
genes like me logo Genes that share ontologies with PRUNE1: view

No data available for SIGNOR curated interactions for PRUNE1 Gene

Drugs & Compounds for PRUNE1 Gene

(5) Drugs for PRUNE1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 35
cyclic amp Experimental Pharma 0
Magnesium Nutra 0

(4) Additional Compounds for PRUNE1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Guanosine 3',5'-bis(diphosphate)
Guanosine 3'-diphosphate 5'-triphosphate
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with PRUNE1: view

Transcripts for PRUNE1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRUNE1 Gene

No ASD Table

Relevant External Links for PRUNE1 Gene

GeneLoc Exon Structure for
PRUNE1
ECgene alternative splicing isoforms for
PRUNE1

Expression for PRUNE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRUNE1 Gene:

PRUNE1

mRNA Expression by UniProt/SwissProt for PRUNE1 Gene:

Q86TP1-PRUN1_HUMAN
Tissue specificity: Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.

Evidence on tissue expression from TISSUES for PRUNE1 Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Thyroid gland(4.3)
  • Blood(4.2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRUNE1 Gene

Orthologs for PRUNE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRUNE1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PRUNE 33 34
  • 91.02 (n)
cow
(Bos Taurus)
Mammalia PRUNE 33 34
  • 89.77 (n)
mouse
(Mus musculus)
Mammalia Prune 33 34
  • 85.28 (n)
Prune1 16
rat
(Rattus norvegicus)
Mammalia Prune 33
  • 84.92 (n)
oppossum
(Monodelphis domestica)
Mammalia PRUNE 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRUNE 34
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRUNE 34 33
  • 58.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRUNE 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prune 33
  • 58.15 (n)
Str.16711 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14865 33
zebrafish
(Danio rerio)
Actinopterygii LOC563343 33
  • 57.87 (n)
prune 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pn 33 34
  • 48.4 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004314 33
  • 44.89 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPX1 33 34 36
  • 43 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL083W 33
  • 41.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03806g 33
  • 41.03 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2F3.11 33
  • 39.74 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06310 33
  • 38.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToOne
Species where no ortholog for PRUNE1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRUNE1 Gene

ENSEMBL:
Gene Tree for PRUNE1 (if available)
TreeFam:
Gene Tree for PRUNE1 (if available)

Paralogs for PRUNE1 Gene

Pseudogenes.org Pseudogenes for PRUNE1 Gene

genes like me logo Genes that share paralogs with PRUNE1: view

No data available for Paralogs for PRUNE1 Gene

Variants for PRUNE1 Gene

Sequence variations from dbSNP and Humsavar for PRUNE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_078986 Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA) [MIM:617481]
VAR_078987 Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA) [MIM:617481]
VAR_078988 Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA) [MIM:617481]
VAR_078989 Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA) [MIM:617481]
VAR_078991 Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA) [MIM:617481]

Structural Variations from Database of Genomic Variants (DGV) for PRUNE1 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV gain 19592680
nsv1127030 CNV deletion 24896259

Variation tolerance for PRUNE1 Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRUNE1 Gene

Human Gene Mutation Database (HGMD)
PRUNE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRUNE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRUNE1 Gene

Disorders for PRUNE1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRUNE1 Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRUNE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRUNE1
genes like me logo Genes that share disorders with PRUNE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRUNE1 Gene

Publications for PRUNE1 Gene

  1. Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity. (PMID: 11687967) Forus A … Zollo M (Oncogene 2001) 2 3 4 60
  2. Evidence for interaction between human PRUNE and nm23-H1 NDPKinase. (PMID: 10602478) Reymond A … Zollo M (Oncogene 1999) 2 3 4 60
  3. Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase. (PMID: 18700747) Tammenkoski M … Lahti R (Biochemistry 2008) 2 3 60
  4. Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain. (PMID: 17655525) Middelhaufe S … Steegborn C (The Biochemical journal 2007) 3 4 60
  5. Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. (PMID: 16428445) Kobayashi T … Kikuchi A (Molecular and cellular biology 2006) 3 4 60

Products for PRUNE1 Gene

Sources for PRUNE1 Gene

Content
Loading form....