Aliases for PRUNE Gene
External Ids for PRUNE Gene
Previous GeneCards Identifiers for PRUNE Gene
This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for PRUNE Gene
PRUNE (Prune Exopolyphosphatase) is a Protein Coding gene. Diseases associated with PRUNE include Nerve Compression Syndrome. Among its related pathways are Pyrimidine metabolism (KEGG). GO annotations related to this gene include pyrophosphatase activity and inorganic diphosphatase activity.
UniProtKB/Swiss-Prot for PRUNE Gene
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.