Aliases for PRUNE Gene
External Ids for PRUNE Gene
Previous GeneCards Identifiers for PRUNE Gene
This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for PRUNE Gene
PRUNE (Prune Exopolyphosphatase) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG). GO annotations related to this gene include pyrophosphatase activity and inorganic diphosphatase activity.
UniProtKB/Swiss-Prot for PRUNE Gene
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.