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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRUNE Gene

protein-coding   GIFtS: 61
GCID: GC01P150980

Prune Exopolyphosphatase

(Previous name: prune homolog (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prune Exopolyphosphatase1 2     Prune Homolog2
DRES-172 3     EC 3.6.1.13
DRES172 3     HTcD373
Drosophila-Related Expressed Sequence 172 3     hPrune3
Prune Homolog (Drosophila)1     BMCC15
HTCD372     KIAA03675
Protein Prune Homolog2     PRUNE25

External Ids:    HGNC: 134201   Entrez Gene: 584972   Ensembl: ENSG000001433637   OMIM: 6106915   UniProtKB: Q86TP13   

Export aliases for PRUNE gene to outside databases

Previous GC identifers: GC01P147796 GC01P149247 GC01P122357


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PRUNE Gene: 
PRUNE (prune exopolyphosphatase) is a protein-coding gene. Diseases associated with PRUNE include necrotizing gastritis, and bladder diverticulum, and among its related super-pathways are Pyrimidine metabolism. GO annotations related to this gene include manganese ion binding and inorganic diphosphatase activity.

UniProtKB/Swiss-Prot: PRUNE_HUMAN, Q86TP1
Function: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in
cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRUNE gene promoter:
         Bach1   Sp1   MAZR   IRF-1   Ik-2   HOXA5   c-Myb   ARP-1   Msx-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRUNE promoter sequence
   Search SABiosciences Chromatin IP Primers for PRUNE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRUNE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

PRUNE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRUNE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P150980:  view genomic region     (about GC identifiers)

Start:
150,980,896 bp from pter      End:
151,008,189 bp from pter
Size:
27,294 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRUNE_HUMAN, Q86TP1 (See protein sequence)
Recommended Name: Protein prune homolog  
Size: 453 amino acids; 50200 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Subunit: Homooligomer. Able to homodimerize via its C-terminal domain. Interacts with NME1. Interacts with GSK3;
at focal adhesion complexes where paxillin and vinculin are colocalized
Subcellular location: Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear
staining is also observed
Sequence caution: Sequence=BAB55423.1; Type=Erroneous initiation; Sequence=BAG60534.1; Type=Erroneous initiation;
Secondary accessions: B2RCH8 B4DFL7 Q5SZF9 Q659E5 Q6P4E0 Q8N654 Q96JU5 Q9C071 Q9C072 Q9UIV0
Alternative splicing: 7 isoforms:  Q86TP1-1   Q86TP1-2   Q86TP1-3   Q86TP1-4   Q86TP1-5   Q86TP1-6   Q86TP1-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRUNE: NX_Q86TP1

Explore proteomics data for PRUNE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86TP1

  • PRUNE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRUNE Protein Expression
    REFSEQ proteins: NP_067045.1  
    ENSEMBL proteins: 
     ENSP00000387696   ENSP00000271620   ENSP00000357933   ENSP00000392632   ENSP00000357932  
     ENSP00000357931   ENSP00000357930   ENSP00000271619  

    Human Recombinant Protein Products for PRUNE: 
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    Novus Biologicals PRUNE Protein
    Novus Biologicals PRUNE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRUNE 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005925focal adhesion IEA--

    PRUNE for ontologies           About GeneDecksing



    PRUNE Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR004097 DHHA2
     IPR001667 Pesterase_RecJ

    Graphical View of Domain Structure for InterPro Entry Q86TP1

    ProtoNet protein and cluster: Q86TP1

    2 Blocks protein domains:
    IPB001667 Phosphoesterase
    IPB004097 DHHA2 domain


    UniProtKB/Swiss-Prot: PRUNE_HUMAN, Q86TP1
    Similarity: Belongs to the PPase class C family. Prune subfamily


    PRUNE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRUNE_HUMAN, Q86TP1
    Function: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in
    cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1
    Catalytic activity: Diphosphate + H(2)O = 2 phosphate
    Enzyme regulation: Activated by magnesium ions and inhibited by manganese ions. Inhibited by dipyridamole,
    moderately sensitive to IBMX and inhibited by vinpocetine
    Biophysicochemical properties: Kinetic parameters: KM=0.91 uM for cAMP; KM=2.3 uM for cGMP; Vmax=12.8 pmol/min/ug
    enzyme with cAMP as substrate; Vmax=0.8 pmol/min/ug enzyme with cGMP as substrate;

         Enzyme Number (IUBMB): EC 3.6.1.11

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004427inorganic diphosphatase activity IEA--
    GO:0005515protein binding IPI10602478
    GO:0016462pyrophosphatase activity ----
    GO:0016787hydrolase activity ----
    GO:0030145manganese ion binding IEA--
         
    PRUNE for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRUNE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRUNE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRUNE 
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    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate PRUNE (see all 32):
    hsa-miR-142-5p hsa-miR-4254 hsa-miR-548k hsa-miR-218-1* hsa-miR-371-5p hsa-miR-9 hsa-miR-3908 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidPRUNE 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRUNE About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Purine metabolism
    Purine metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for PRUNE):
        Purine metabolism


    PRUNE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRUNE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for PRUNE (Q86TP11, 3 ENSP000002716204) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME1P155311, 3, ENSP000000130344EBI-2127112,EBI-741141 I2D: score=4 STRING: ENSP00000013034
    GTF2H3Q138893I2D: score=5 
    ARFGEF1Q9Y6D63I2D: score=3 
    PSMD14O004873I2D: score=2 
    ACTR2P611603I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRUNE

    5 HMDB Compounds for PRUNE    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about PRUNE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRUNE gene: 
    NM_021222.1  

    Unigene Cluster for PRUNE:

    Prune homolog (Drosophila)
    Hs.78524  [show with all ESTs]
    Unigene Representative Sequence: AF051907
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467771 ENST00000462440 ENST00000475722 ENST00000450884 ENST00000271620(uc001ewh.1)
    ENST00000368937 ENST00000431193 ENST00000368936(uc001ewi.1 uc010pco.1 uc001ewj.1 uc001ewk.1)
    ENST00000368935 ENST00000368934 ENST00000271619
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRUNE
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate PRUNE (see all 32):
    hsa-miR-142-5p hsa-miR-4254 hsa-miR-548k hsa-miR-218-1* hsa-miR-371-5p hsa-miR-9 hsa-miR-3908 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidPRUNE 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRUNE
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRUNE
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    Sirion Biotech Customized lentivirus for stable overexpression of PRUNE 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRUNE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRUNE

    Additional mRNA sequence: 

    AF051907.1 AF123538.1 AF123539.1 AK027875.1 AK294154.1 AK298273.1 AK315120.1 AK316537.1 
    AL122054.1 AL137324.1 BC014886.1 BC017755.1 BC025304.1 BC063481.1 U67085.1 

    9 DOTS entries:

    DT.455569  DT.100788067  DT.100788068  DT.100733593  DT.92434049  DT.100658911  DT.92434052  DT.92434053 
    DT.95275267 

    24/166 AceView cDNA sequences (see all 166):

    BM724919 AW192954 AW675784 CF552563 F02409 BQ446824 AL137324 AI126519 
    BM998954 AA772558 W15529 BM505549 BM466111 BU509054 BU740455 BM700237 
    AA565322 AA772248 Z43129 AK027875 BQ420502 BE502698 AA992460 BC014886 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PRUNE (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:                                      -                                                                                   -                                 
    SP2:                                      -           -     -     -                                                           -                                 
    SP3:                                                                    -     -     -     -     -     -                       -                                 
    SP4:                                                  -                                                                                                         
    SP5:                                                                                                              -     -     -                                 


    ECgene alternative splicing isoforms for PRUNE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRUNE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCAAAGGA
    PRUNE Expression
    About this image


    See PRUNE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRUNE

    SOURCE GeneReport for Unigene cluster: Hs.78524

    UniProtKB/Swiss-Prot: PRUNE_HUMAN, Q86TP1
    Tissue specificity: Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as
    leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas

        SABiosciences Custom PCR Arrays for PRUNE
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRUNE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRUNE gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prune1 , 5 prune homolog (Drosophila)1, 5 85.28(n)1
    85.65(a)1
      3 (40.74 cM)5
    2295891  NM_173347.21  NP_775482.11 
     952536745 
    chicken
    (Gallus gallus)
    Aves LOC1008572901 protein prune homolog 58.74(n)
    57.28(a)
      100857290  XM_003642683.1  XP_003642731.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRUNE6
    Uncharacterized protein
    53(a)
    1 ↔ 1
    GL344087.1(38720-64263)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.148652 Xenopus laevis transcribed sequences 74.3(n)    CA788231.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5633431 prune 57.72(n)
    50.69(a)
      563343  NM_001160294.1  NP_001153766.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pn1 prune 47.55(n)
    36.64(a)
      31194  NM_057336.4  NP_476684.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PPX1(YHR201C)4
    PPX11
    Exopolyphosphatase, hydrolyzes inorganic polyphosphate more4
    Ppx1p1
    43.41(n)1
    28.14(a)1
      8(501143-499950)4
    8566081, 4  NP_012071.11, 4 


    ENSEMBL Gene Tree for PRUNE (if available)
    TreeFam Gene Tree for PRUNE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRUNE gene
    1 SIMAP similar gene for PRUNE using alignment to 4 protein entries:     PRUNE_HUMAN (see all proteins):
    PRUNE2

    PRUNE for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PRUNE
    PGOHUM00000248340


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/569 SNPs in PRUNE are shown (see all 569)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823456651,2
    --122359922(+) GCTGGA/CATCTC 1 -- int10--------
    rs1148374101,2
    C--122360115(+) ATACTG/AGTAGA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs716245181,2
    C--122360222(+) CTTCCC/TGAATT 1 -- int14Minor allele frequency- T:0.17NA WA EA 360
    rs346169161,2
    C--122360277(+) AGTGTG/ACGCCA 1 -- int12Minor allele frequency- A:0.14NA 122
    rs562604901,2
    C,F--122360503(+) TGAAAT/AGAAAA 1 -- int13Minor allele frequency- A:0.10WA CSA 122
    rs561756271,2
    C,F--122360518(+) AAAGAT/ACATTT 1 -- int13Minor allele frequency- A:0.10WA CSA 122
    rs1870593601,2
    --122360533(+) TTTCTC/TCTCTC 1 -- int10--------
    rs121194091,2
    C,F,H--122360558(+) GAGGAC/GACCGT 1 -- int117Minor allele frequency- G:0.39NS EA NA WA 1194
    rs1485376941,2
    --122360562(+) ACACCA/GTTAAG 1 -- int10--------
    rs1442618541,2
    --122360576(+) CTTGTA/GTAAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for PRUNE (150980896 - 151008189 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRUNE:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522840CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PRUNE
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610691    OMIM disorders: --

    20/32 diseases for PRUNE (see all 32):    About MalaCards
    necrotizing gastritis    bladder diverticulum    ureterocele    urethral obstruction
    urethritis    urinary tract obstruction    congenital mesoblastic nephroma    edwards syndrome
    vacterl association    hydronephrosis    mesoblastic nephroma    imperforate anus
    neurogenic bladder    gastroschisis    oligohydramnios    renal agenesis
    congenital diaphragmatic hernia    vesicoureteral reflux    hernia    fibrous histiocytoma


    PRUNE for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRUNE
    Human Genome Epidemiology (HuGE) Navigator: PRUNE (1 document)

    Export disorders for PRUNE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRUNE gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with PRUNE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity. (PubMed id 11687967)1, 2, 3 Forus A....Zollo M. (2001)
    2. Evidence for interaction between human PRUNE and nm23-H1 NDPKinase. (PubMed id 10602478)1, 2, 3 Reymond A.... Zollo M. (1999)
    3. Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase. (PubMed id 18700747)1, 3 Tammenkoski M....Lahti R. (2008)
    4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (2008)
    5. Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain. (PubMed id 17655525)1, 2 Middelhaufe S....Steegborn C. (2007)
    6. Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. (PubMed id 16428445)1, 2 Kobayashi T....Kikuchi A. (2006)
    7. Overexpression of h-prune in breast cancer is correlated with advanced disease status. (PubMed id 15671547)1, 2 Zollo M....Palmieri G. (2005)
    8. Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein. (PubMed id 10524757)1, 2 Volorio S.... Zollo M. (1998)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. Neuroblastoma tumorigenesis is regulated through the N m23-H1/h-Prune C-terminal interaction. (PubMed id 23448979)1 Carotenuto M....Zollo M. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58497 HGNC: 13420 AceView: HTCD37 Ensembl:ENSG00000143363 euGenes: HUgn58497
    ECgene: PRUNE Kegg: 58497 H-InvDB: PRUNE

    (According to HUGE)
    About This Section
    HUGE: KIAA0367

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRUNE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRUNE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRUNE gene:
    Search GeneIP for patents involving PRUNE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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