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Aliases for PRUNE Gene

Aliases for PRUNE Gene

  • Prune Exopolyphosphatase 2 3 5
  • Drosophila-Related Expressed Sequence 17 3 4
  • DRES-17 3 4
  • HTCD37 3 4
  • DRES17 3 4
  • Prune Homolog (Drosophila) 2
  • EC 3.6.1.1 4
  • HPrune 4

External Ids for PRUNE Gene

Previous GeneCards Identifiers for PRUNE Gene

  • GC01P147796
  • GC01P149247
  • GC01P122357

Summaries for PRUNE Gene

Entrez Gene Summary for PRUNE Gene

  • This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for PRUNE Gene

PRUNE (Prune Exopolyphosphatase) is a Protein Coding gene. Diseases associated with PRUNE include nerve compression syndrome. Among its related pathways are Pyrimidine metabolism (KEGG). GO annotations related to this gene include pyrophosphatase activity and inorganic diphosphatase activity.

UniProtKB/Swiss-Prot for PRUNE Gene

  • Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRUNE Gene

Genomics for PRUNE Gene

Regulatory Elements for PRUNE Gene

Genomic Location for PRUNE Gene

Chromosome:
1
Start:
151,008,391 bp from pter
End:
151,035,713 bp from pter
Size:
27,323 bases
Orientation:
Plus strand

Genomic View for PRUNE Gene

Genes around PRUNE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRUNE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRUNE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRUNE Gene

Proteins for PRUNE Gene

  • Protein details for PRUNE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TP1-PRUNE_HUMAN
    Recommended name:
    Protein prune homolog
    Protein Accession:
    Q86TP1
    Secondary Accessions:
    • B2RCH8
    • B4DFL7
    • Q5SZF9
    • Q659E5
    • Q6P4E0
    • Q8N654
    • Q96JU5
    • Q9C071
    • Q9C072
    • Q9UIV0

    Protein attributes for PRUNE Gene

    Size:
    453 amino acids
    Molecular mass:
    50200 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homooligomer. Able to homodimerize via its C-terminal domain. Interacts with NME1. Interacts with GSK3; at focal adhesion complexes where paxillin and vinculin are colocalized.
    SequenceCaution:
    • Sequence=BAB55423.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG60534.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PRUNE Gene

neXtProt entry for PRUNE Gene

Proteomics data for PRUNE Gene at MOPED

Post-translational modifications for PRUNE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PRUNE Gene

Domains & Families for PRUNE Gene

Protein Domains for PRUNE Gene

Suggested Antigen Peptide Sequences for PRUNE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TP1

UniProtKB/Swiss-Prot:

PRUNE_HUMAN :
  • Belongs to the PPase class C family. Prune subfamily.
Family:
  • Belongs to the PPase class C family. Prune subfamily.
genes like me logo Genes that share domains with PRUNE: view

No data available for Gene Families for PRUNE Gene

Function for PRUNE Gene

Molecular function for PRUNE Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.91 uM for cAMP {ECO:0000269 PubMed:14998490, ECO:0000269 PubMed:17655525}; KM=2.3 uM for cGMP {ECO:0000269 PubMed:14998490, ECO:0000269 PubMed:17655525}; Vmax=12.8 pmol/min/ug enzyme with cAMP as substrate {ECO:0000269 PubMed:14998490, ECO:0000269 PubMed:17655525}; Vmax=0.8 pmol/min/ug enzyme with cGMP as substrate {ECO:0000269 PubMed:14998490, ECO:0000269 PubMed:17655525};
UniProtKB/Swiss-Prot CatalyticActivity:
Diphosphate + H(2)O = 2 phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by magnesium ions and inhibited by manganese ions. Inhibited by dipyridamole, moderately sensitive to IBMX and inhibited by vinpocetine.
UniProtKB/Swiss-Prot Function:
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.

Enzyme Numbers (IUBMB) for PRUNE Gene

Gene Ontology (GO) - Molecular Function for PRUNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004427 inorganic diphosphatase activity IEA --
genes like me logo Genes that share ontologies with PRUNE: view

Phenotypes for PRUNE Gene

genes like me logo Genes that share phenotypes with PRUNE: view

Animal Model Products

miRNA for PRUNE Gene

miRTarBase miRNAs that target PRUNE

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRUNE Gene

Localization for PRUNE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRUNE Gene

Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRUNE Gene COMPARTMENTS Subcellular localization image for PRUNE gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for PRUNE Gene

Pathways & Interactions for PRUNE Gene

SuperPathways for PRUNE Gene

Superpath Contained pathways
1 Pyrimidine metabolism (KEGG)
genes like me logo Genes that share pathways with PRUNE: view

Pathways by source for PRUNE Gene

1 KEGG pathway for PRUNE Gene

Gene Ontology (GO) - Biological Process for PRUNE Gene

None

No data available for SIGNOR curated interactions for PRUNE Gene

Drugs & Compounds for PRUNE Gene

(4) Drugs for PRUNE Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Diphosphate Experimental Pharma 0
Manganese Pharma 32
Magnesium Nutra 0

(5) Additional Compounds for PRUNE Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Guanosine 3',5'-bis(diphosphate)
Guanosine 3'-diphosphate 5'-triphosphate
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PRUNE: view

Transcripts for PRUNE Gene

Unigene Clusters for PRUNE Gene

Prune homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRUNE Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - -
SP9: - -
SP10: -
SP11: - - - - - - - - - - - - -
SP12:

Relevant External Links for PRUNE Gene

GeneLoc Exon Structure for
PRUNE
ECgene alternative splicing isoforms for
PRUNE

Expression for PRUNE Gene

mRNA expression in normal human tissues for PRUNE Gene

Protein differential expression in normal tissues from HIPED for PRUNE Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.3) and Platelet (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRUNE Gene



SOURCE GeneReport for Unigene cluster for PRUNE Gene Hs.78524

mRNA Expression by UniProt/SwissProt for PRUNE Gene

Q86TP1-PRUNE_HUMAN
Tissue specificity: Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
genes like me logo Genes that share expression patterns with PRUNE: view

Protein tissue co-expression partners for PRUNE Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRUNE Gene

Orthologs for PRUNE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRUNE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRUNE 35
  • 89.77 (n)
  • 88.52 (a)
PRUNE 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRUNE 35
  • 91.02 (n)
  • 90.51 (a)
PRUNE 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prune 35
  • 85.28 (n)
  • 85.65 (a)
Prune 16
Prune 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prune 35
  • 84.92 (n)
  • 85.43 (a)
oppossum
(Monodelphis domestica)
Mammalia PRUNE 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRUNE 36
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857290 35
  • 58.74 (n)
  • 57.28 (a)
PRUNE 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRUNE 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prune 35
  • 58.15 (n)
  • 53.11 (a)
Str.16711 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14865 35
zebrafish
(Danio rerio)
Actinopterygii LOC563343 35
  • 57.87 (n)
  • 50.69 (a)
prune 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004314 35
  • 44.89 (n)
  • 35.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta pn 35
  • 48.4 (n)
  • 37.13 (a)
pn 36
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL083W 35
  • 41.57 (n)
  • 27.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03806g 35
  • 41.03 (n)
  • 29.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPX1 35
  • 43 (n)
  • 30.51 (a)
PPX1 36
  • 24 (a)
OneToOne
PPX1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU06310 35
  • 38.38 (n)
  • 28.01 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2F3.11 35
  • 39.74 (n)
  • 27.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for PRUNE:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRUNE Gene

ENSEMBL:
Gene Tree for PRUNE (if available)
TreeFam:
Gene Tree for PRUNE (if available)

Paralogs for PRUNE Gene

(1) SIMAP similar genes for PRUNE Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PRUNE Gene

genes like me logo Genes that share paralogs with PRUNE: view

No data available for Paralogs for PRUNE Gene

Variants for PRUNE Gene

Sequence variations from dbSNP and Humsavar for PRUNE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3738477 -, - 151,034,061(-) CAGGC(C/T)AGAAA nc-transcript-variant, reference, missense
rs1673161 -- 151,014,186(+) aggtt(A/G)gccag intron-variant
rs2445894 -- 151,014,754(+) actgg(G/T)ggcag intron-variant
rs3002292 -- 151,016,159(-) cctgg(G/T)ttcaa intron-variant, upstream-variant-2KB
rs2864701 -- 151,028,386(-) ggcac(A/G)cacca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRUNE Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680

Variation tolerance for PRUNE Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRUNE Gene

HapMap Linkage Disequilibrium report
PRUNE
Human Gene Mutation Database (HGMD)
PRUNE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRUNE Gene

Disorders for PRUNE Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRUNE Gene - From: DISEASES

Disorder Aliases PubMed IDs
nerve compression syndrome
  • compression neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search PRUNE in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRUNE

Genetic Association Database (GAD)
PRUNE
Human Genome Epidemiology (HuGE) Navigator
PRUNE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRUNE
genes like me logo Genes that share disorders with PRUNE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRUNE Gene

Publications for PRUNE Gene

  1. Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity. (PMID: 11687967) Forus A. … Zollo M. (Oncogene 2001) 2 3 4 67
  2. Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase. (PMID: 18700747) Tammenkoski M. … Lahti R. (Biochemistry 2008) 2 3
  3. Evidence for interaction between human PRUNE and nm23-H1 NDPKinase. (PMID: 10602478) Reymond A. … Zollo M. (Oncogene 1999) 2 3
  4. A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction. (PMID: 25138575) Carotenuto M. … Zollo M. (Naunyn Schmiedebergs Arch. Pharmacol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for PRUNE Gene

Sources for PRUNE Gene

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