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PRUNE Gene

protein-coding   GIFtS: 61
GCID: GC01P150980

Prune Exopolyphosphatase

(Previous name: prune homolog (Drosophila))
  Search for PRUNE
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prune Exopolyphosphatase1 2     Prune Homolog2
DRES-172 3     EC 3.6.1.13
DRES172 3     HTcD373
Drosophila-Related Expressed Sequence 172 3     hPrune3
Prune Homolog (Drosophila)1     BMCC15
HTCD372     KIAA03675
Protein Prune Homolog2     PRUNE25

External Ids:    HGNC: 134201   Entrez Gene: 584972   Ensembl: ENSG000001433637   OMIM: 6106915   UniProtKB: Q86TP13   

Export aliases for PRUNE gene to outside databases

Previous GC identifers: GC01P147796 GC01P149247 GC01P122357


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRUNE Gene:
PRUNE (prune exopolyphosphatase) is a protein-coding gene. GO annotations related to this gene include manganese ion binding and inorganic diphosphatase activity.

UniProtKB/Swiss-Prot: PRUNE_HUMAN, Q86TP1
Function: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in
cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRUNE gene promoter:
         Bach1   Sp1   MAZR   IRF-1   Ik-2   HOXA5   c-Myb   ARP-1   Msx-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRUNE promoter sequence
   Search Chromatin IP Primers for PRUNE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRUNE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

PRUNE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRUNE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P150980:  view genomic region     (about GC identifiers)

Start:
150,980,896 bp from pter      End:
151,008,189 bp from pter
Size:
27,294 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRUNE_HUMAN, Q86TP1 (See protein sequence)
Recommended Name: Protein prune homolog  
Size: 453 amino acids; 50200 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Subunit: Homooligomer. Able to homodimerize via its C-terminal domain. Interacts with NME1. Interacts with GSK3;
at focal adhesion complexes where paxillin and vinculin are colocalized
Sequence caution: Sequence=BAB55423.1; Type=Erroneous initiation; Sequence=BAG60534.1; Type=Erroneous initiation;
Secondary accessions: B2RCH8 B4DFL7 Q5SZF9 Q659E5 Q6P4E0 Q8N654 Q96JU5 Q9C071 Q9C072 Q9UIV0
Alternative splicing: 7 isoforms:  Q86TP1-1   Q86TP1-2   Q86TP1-3   Q86TP1-4   Q86TP1-5   Q86TP1-6   Q86TP1-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRUNE: NX_Q86TP1

Explore proteomics data for PRUNE at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PRUNE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067045.1  
    ENSEMBL proteins: 
     ENSP00000387696   ENSP00000271620   ENSP00000357933   ENSP00000392632   ENSP00000357932  
     ENSP00000357931   ENSP00000357930   ENSP00000271619  

    PRUNE Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for PRUNE
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PRUNE
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    Novus Biologicals PRUNE Protein
    Novus Biologicals PRUNE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRUNE

     
    Search eBioscience for Proteins for PRUNE 

    PRUNE Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRUNE
    Browse R&D Systems for Antibodies
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    Abcam antibodies for PRUNE
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    ThermoFisher Antibody for PRUNE
    LSBio Antibodies in human, mouse, rat for PRUNE

    PRUNE Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PRUNE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRUNE
    Cloud-Clone Corp. CLIAs for PRUNE
    Search eBioscience for ELISAs for PRUNE 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004097 DHHA2
     IPR001667 Pesterase_RecJ

    Graphical View of Domain Structure for InterPro Entry Q86TP1

    ProtoNet protein and cluster: Q86TP1

    2 Blocks protein domains:
    IPB001667 Phosphoesterase
    IPB004097 DHHA2 domain


    UniProtKB/Swiss-Prot: PRUNE_HUMAN, Q86TP1
    Similarity: Belongs to the PPase class C family. Prune subfamily


    Find genes that share domains with PRUNE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRUNE_HUMAN, Q86TP1
    Function: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in
    cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1
    Catalytic activity: Diphosphate + H(2)O = 2 phosphate
    Enzyme regulation: Activated by magnesium ions and inhibited by manganese ions. Inhibited by dipyridamole,
    moderately sensitive to IBMX and inhibited by vinpocetine
    Biophysicochemical properties: Kinetic parameters: KM=0.91 uM for cAMP; KM=2.3 uM for cGMP; Vmax=12.8 pmol/min/ug
    enzyme with cAMP as substrate; Vmax=0.8 pmol/min/ug enzyme with cGMP as substrate;

         Enzyme Number (IUBMB): EC 3.6.1.11

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004427inorganic diphosphatase activity IEA--
    GO:0005515protein binding IPI10602478
    GO:0016462pyrophosphatase activity ----
    GO:0016787hydrolase activity ----
    GO:0030145manganese ion binding IEA--
         
    Find genes that share ontologies with PRUNE           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRUNE
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRUNE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRUNE

    miRNA
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    miRTarBase miRNAs that target PRUNE:
    hsa-mir-769-5p (MIRT039197), hsa-mir-130b-3p (MIRT020306), hsa-mir-196a-5p (MIRT026082), hsa-mir-19b-3p (MIRT031283), hsa-mir-93-5p (MIRT028167)

    Block miRNA regulation of human, mouse, rat PRUNE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRUNE (see all 32):
    hsa-miR-142-5p hsa-miR-4254 hsa-miR-548k hsa-miR-218-1* hsa-miR-371-5p hsa-miR-9 hsa-miR-3908 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidPRUNE 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PRUNE
    Predesigned siRNA for gene silencing in human, mouse, rat PRUNE

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PRUNE

    Clone
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    OriGene clones in human, mouse for PRUNE (see all 6)
    OriGene ORF clones in mouse, rat for PRUNE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRUNE (NM_021222)
    Sino Biological Human cDNA Clone for PRUNE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRUNE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRUNE

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PRUNE 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRUNE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRUNE_HUMAN, Q86TP1: Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear
    staining is also observed
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005925focal adhesion IEA--

    Find genes that share ontologies with PRUNE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRUNE About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Purine metabolism0.38


    Find genes that share SuperPaths with PRUNE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for PRUNE):
        Purine metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRUNE
    Interactions:

        GeneGlobe Interaction Network for PRUNE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRUNE (Q86TP11, 3 ENSP000002716204) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME1P155311, 3, ENSP000000130344EBI-2127112,EBI-741141 I2D: score=4 STRING: ENSP00000013034
    ARFGEF1Q9Y6D63, ENSP000002622154I2D: score=3 STRING: ENSP00000262215
    GTF2H3Q138893I2D: score=5 
    PSMD14O004873I2D: score=2 
    ACTR2P611603I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRUNE

    5 HMDB Compounds for PRUNE    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRUNE gene: 
    NM_021222.1  

    Unigene Cluster for PRUNE:

    Prune homolog (Drosophila)
    Hs.78524  [show with all ESTs]
    Unigene Representative Sequence: AF051907
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467771 ENST00000462440 ENST00000475722 ENST00000450884 ENST00000271620(uc001ewh.1)
    ENST00000368937 ENST00000431193 ENST00000368936(uc001ewi.1 uc010pco.1 uc001ewj.1 uc001ewk.1)
    ENST00000368935 ENST00000368934 ENST00000271619
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRUNE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRUNE (see all 32):
    hsa-miR-142-5p hsa-miR-4254 hsa-miR-548k hsa-miR-218-1* hsa-miR-371-5p hsa-miR-9 hsa-miR-3908 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidPRUNE 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PRUNE
    Predesigned siRNA for gene silencing in human, mouse, rat PRUNE
    Clone
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    OriGene clones in human, mouse for PRUNE (see all 6)
    OriGene ORF clones in mouse, rat for PRUNE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRUNE (NM_021222)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRUNE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRUNE
    Primer
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    OriGene qPCR primer pairs and template standards for PRUNE
    OriGene qSTAR qPCR primer pairs in human, mouse for PRUNE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRUNE
      QuantiTect SYBR Green Assays in human, mouse, rat PRUNE
      QuantiFast Probe-based Assays in human, mouse, rat PRUNE

    Additional mRNA sequence: 

    AF051907.1 AF123538.1 AF123539.1 AK027875.1 AK294154.1 AK298273.1 AK315120.1 AK316537.1 
    AL122054.1 AL137324.1 BC014886.1 BC017755.1 BC025304.1 BC063481.1 U67085.1 

    9 DOTS entries:

    DT.455569  DT.100788067  DT.100788068  DT.100733593  DT.92434049  DT.100658911  DT.92434052  DT.92434053 
    DT.95275267 

    Selected AceView cDNA sequences (see all 166):

    AA255525 BC063481 AA565322 BM680152 AA772558 BX418574 CD244622 BC014886 
    BE327631 CR614108 AW192954 AA772248 AW300687 BM724919 BQ446824 CR591415 
    BM505549 BM700237 BM998954 AA490627 AW168493 AA992460 AW673462 AK027875 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRUNE (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:                                      -                                                                                   -                                 
    SP2:                                      -           -     -     -                                                           -                                 
    SP3:                                                                    -     -     -     -     -     -                       -                                 
    SP4:                                                  -                                                                                                         
    SP5:                                                                                                              -     -     -                                 


    ECgene alternative splicing isoforms for PRUNE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRUNE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCAAAGGA
    PRUNE Expression
    About this image

    PRUNE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRUNE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78524

    UniProtKB/Swiss-Prot: PRUNE_HUMAN, Q86TP1
    Tissue specificity: Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as
    leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas

        Custom PCR Arrays for PRUNE
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    QuantiTect SYBR Green Assays in human, mouse, rat PRUNE
    QuantiFast Probe-based Assays in human, mouse, rat PRUNE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRUNE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRUNE gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prune1 , 5 prune homolog (Drosophila)1, 5 85.28(n)1
    85.65(a)1
      3 (40.74 cM)5
    2295891  NM_173347.21  NP_775482.11 
     952536745 
    chicken
    (Gallus gallus)
    Aves LOC1008572901 protein prune homolog 58.74(n)
    57.28(a)
      100857290  XM_004948345.1  XP_004948402.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRUNE6
    prune exopolyphosphatase
    54(a)
    1 ↔ 1
    GL344087.1(38720-64263)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.148652 Xenopus laevis transcribed sequences 74.3(n)    CA788231.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5633431 prune 57.87(n)
    50.69(a)
      563343  NM_001160294.1  NP_001153766.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pn1 prune 48.4(n)
    37.13(a)
      31194  NM_057336.4  NP_476684.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PPX1(YHR201C)4
    PPX11
    Exopolyphosphatase, hydrolyzes inorganic polyphosphate more4
    PPX11
    43(n)1
    30.51(a)1
      8(501143-499950)4
    8566081, 4  NP_012071.11, 4 


    ENSEMBL Gene Tree for PRUNE (if available)
    TreeFam Gene Tree for PRUNE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRUNE gene
    1 SIMAP similar gene for PRUNE using alignment to 4 protein entries:     PRUNE_HUMAN (see all proteins):
    PRUNE2

    Find genes that share paralogs with PRUNE           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PRUNE
    PGOHUM00000248340


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRUNE (see all 569)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823456651,2
    --122359922(+) GCTGGA/CATCTC 1 -- int10--------
    rs1148374101,2
    C--122360115(+) ATACTG/AGTAGA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs716245181,2
    C--122360222(+) CTTCCC/TGAATT 1 -- int14Minor allele frequency- T:0.17NA WA EA 360
    rs346169161,2
    C--122360277(+) AGTGTG/ACGCCA 1 -- int12Minor allele frequency- A:0.14NA 122
    rs562604901,2
    C,F--122360503(+) TGAAAT/AGAAAA 1 -- int13Minor allele frequency- A:0.10WA CSA 122
    rs561756271,2
    C,F--122360518(+) AAAGAT/ACATTT 1 -- int13Minor allele frequency- A:0.10WA CSA 122
    rs1870593601,2
    --122360533(+) TTTCTC/TCTCTC 1 -- int10--------
    rs121194091,2
    C,F,H--122360558(+) GAGGAC/GACCGT 1 -- int117Minor allele frequency- G:0.39NS EA NA WA 1194
    rs1485376941,2
    --122360562(+) ACACCA/GTTAAG 1 -- int10--------
    rs1442618541,2
    --122360576(+) CTTGTA/GTAAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for PRUNE (150980896 - 151008189 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRUNE:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522840CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRUNE
    DNA2.0 Custom Variant and Variant Library Synthesis for PRUNE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610691    OMIM disorders: --


    Find genes that share disorders with PRUNE           About GenesLikeMe

    Genetic Association Database (GAD): PRUNE
    Human Genome Epidemiology (HuGE) Navigator: PRUNE (1 document)

    Export disorders for PRUNE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRUNE gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with PRUNE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity. (PubMed id 11687967)1, 2, 3 Forus A.... Zollo M. (Oncogene 2001)
    2. Evidence for interaction between human PRUNE and nm23-H1 NDPKinase. (PubMed id 10602478)1, 2, 3 Reymond A.... Zollo M. (Oncogene 1999)
    3. Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase. (PubMed id 18700747)1, 3 Tammenkoski M....Lahti R. (Biochemistry 2008)
    4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    5. Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain. (PubMed id 17655525)1, 2 Middelhaufe S....Steegborn C. (Biochem. J. 2007)
    6. Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. (PubMed id 16428445)1, 2 Kobayashi T....Kikuchi A. (Mol. Cell. Biol. 2006)
    7. Overexpression of h-prune in breast cancer is correlated with advanced disease status. (PubMed id 15671547)1, 2 Zollo M.... Palmieri G. (Clin. Cancer Res. 2005)
    8. Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein. (PubMed id 10524757)1, 2 Volorio S.... Zollo M. (DNA Seq. 1998)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction. (PubMed id 23448979)1 Carotenuto M....Zollo M. (Sci Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58497 HGNC: 13420 AceView: HTCD37 Ensembl:ENSG00000143363 euGenes: HUgn58497
    ECgene: PRUNE Kegg: 58497 H-InvDB: PRUNE

    (According to HUGE)
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    HUGE: KIAA0367

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRUNE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRUNE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRUNE gene:
    Search GeneIP for patents involving PRUNE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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