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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRTN3 Gene

protein-coding   GIFtS: 62
GCID: GC19P000840

proteinase 3
 Explore 88 diseases affiliated with
PRTN3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRTN3    

Aliases
for PRTN3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Proteinase 31 2     NP-42 3
AGP71 2 3 5     PR32 3
P291 2 3     C-ANCA Antigen2 3
PR-31 2 3     CANCA2
ACPA1 2     NP42
C-ANCA1 2     Azurophil Granule Protein 72
MBT1 2     Myeloblastin1
Leukocyte Proteinase 32 3     Serine Proteinase, Neutrophil2
Neutrophil Proteinase 42 3     Wegener Granulomatosis Autoantigen2
Wegener Autoantigen2 3     EC 3.4.21.763
MBN2 3     EC 3.4.218

External Ids:    HGNC: 94951   Entrez Gene: 56572   Ensembl: ENSG000001964157   OMIM: 1770205   UniProtKB: P241583   

Export aliases for PRTN3 gene to outside databases

Previous GC identifers: GC19P000922 GC19P000910 GC19P000780 GC19P000793 GC19P000498 GC19P000794 GC19P000610


Summaries
for PRTN3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and
collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters

Gene Wiki entry for PRTN3 (Proteinase 3)


Genomic Views
for PRTN3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRTN3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRTN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRTN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PRTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRTN3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000840:  view genomic region     (about GC identifiers)

Start:
 840,974 bp from pter      End:
 848,180 bp from pter
Size:
 7,207 bases      Orientation:
 plus strand

Proteins
for PRTN3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158 (See protein sequence)
Recommended Name: Myeloblastin precursor  
Size: 256 amino acids; 27807 Da
Sequence caution: Sequence=AAA36342.1; Type=Frameshift; Positions=34, 39; Sequence=CAA39598.1; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for PRTN3:
1FUJ (3D)    
Secondary accessions: P15637 P18078 Q4VB08 Q4VB09 Q6LBM7 Q6LBN2 Q9UD25 Q9UQD8

Explore the universe of human proteins at neXtProt for PRTN3: NX_P24158

4/5 DME Specific Peptides for PRTN3 (P24158) (see all 5)
 GDSGGPL  SGGPLIC  VLTAAHC  PHSRPYMA 

PRTN3 Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_002768.3  
ENSEMBL proteins: 
 ENSP00000234347  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
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Enzo Life Sciences proteins for PRTN3
OriGene Purified Protein: PRTN3
OriGene Protein Over-expression Lysate: PRTN3
OriGene Custom Protein Services for PRTN3 
GenScript Custom Purified and Recombinant Proteins Services for PRTN3
Novus Biologicals PRTN3 Proteins
Novus Biologicals PRTN3 Lysates
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for PRTN3
Uscn Proteins for PRTN3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol IDA17712045
GO:0005886plasma membrane IDA17712045
GO:0031012colocalizes with extracellular matrix IDA--


PRTN3 for ontologies           About GeneDecksing



PRTN3 Antibody Products: 
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R&D Systems Antibodies for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)
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Abcam antibodies for PRTN3 
Uscn Antibodies for PRTN3
ThermoFisher Antibodies for PRTN3

Assay Products for PRTN3: 
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GenScript Custom Assay Services for PRTN3
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for PRTN3

Protein Domains /
Families
for PRTN3 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
PRTN3 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P24158

ProtoNet protein and cluster: P24158

2 Blocks protein families:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
Similarity: Belongs to the peptidase S1 family. Elastase subfamily
Similarity: Contains 1 peptidase S1 domain


Function
for PRTN3 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and
collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters
Catalytic activity: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- -Xaa- > -Val- -Xaa-

     Genatlas biochemistry entry for PRTN3:
proteinase 3,myeloblastin,Wegener autoantigen,responsive to CSF3,stimulated by SPI1,MYB,inducing factor independent
growth of hematopoietic cells

Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.761

miRNA
Products:    		 OriGene 3'-UTR Clone: PRTN3
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRTN3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PRTN3
SwitchGear 3'UTR luciferase reporter plasmid: PRTN3 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRTN3 (see all 7)
OriGene shRNA RFP: PRTN3
OriGene siRNA: PRTN3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRTN3

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for PRTN3

Clone
Products:     		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRTN3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRTN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: PRTN3 (NM_002777)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRTN3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for PRTN3
Search LifeMap BioReagents cell lines for PRTN3

In Situ Assay
Products:   
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PRTN3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004252serine-type endopeptidase activity IEA--
GO:0005515protein binding IPI15527767
GO:0008236serine-type peptidase activity NAS--
GO:0019899enzyme binding IPI17712045


PRTN3 for ontologies           About GeneDecksing


2 GenomeRNAi human phenotypes for PRTN3:
 Decreased viability  Synthetic lethal with Ras 

Animal Models:
     Mouse knock-out Elane/Prtn3Elane/tm1Deje for PRTN3
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Prtn3):
 immune system 

PRTN3 for phenotypes           About GeneDecksing


Pathways & Interactions
for PRTN3 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1C-MYB transcription factor network
C-MYB transcription factor network1.00


1 BioSystems Pathway for PRTN3 
    C-MYB transcription factor network


Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRTN3

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/52 Interacting proteins for PRTN3 (P241581, 2, 3 ENSP000002343474) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
InteractantInteraction Details
GeneCardExternal ID(s)
SMAD3P840221, 3, ENSP000003329734EBI-465028,EBI-1965323 I2D: score=3 STRING: ENSP00000332973
SERPINA1P010093, ENSP000003480684I2D: score=2 STRING: ENSP00000348068
CAMPP499133, ENSP000002964354I2D: score=1 STRING: ENSP00000296435
F2RL1P550853, ENSP000002966774I2D: score=1 STRING: ENSP00000296677
IL32P240013, ENSP000003247424I2D: score=1 STRING: ENSP00000324742
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--
GO:0008284positive regulation of cell proliferation TAS2598267
GO:0030574collagen catabolic process IEA--
GO:0050765negative regulation of phagocytosis IDA17712045
GO:0097029mature dendritic cell differentiation IDA16478888


PRTN3 for ontologies           About GeneDecksing



Drugs & Compounds
for PRTN3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PRTN3 for compounds           About GeneDecksing

EMD Millipore small molecules for PRTN3:
Small Molecule - inhibitor
Enzo Life Sciences drugs & compounds for PRTN3

Browse Tocris compounds for PRTN3
10/44 Novoseek chemical compound relationships for PRTN3 gene (see all 44)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
serine 75.5 224 2033050 (4), 1400430 (3), 11272267 (3), 1681549 (3) (see all 99)
propylthiouracil 63.2 5 10025935 (1), 8103148 (1), 17350787 (1), 17161817 (1)
acpa 58.3 5 1316247 (1), 2240162 (1), 1656761 (1), 1688612 (1)
sulf 55.6 3 7586784 (1), 7612152 (1)
aebsf 53.6 1 12354776 (1)
3,4-dichloroisocoumarin 50.6 4 14525961 (1), 9067256 (1), 1551417 (1)
pmsf 40.3 5 12960243 (1), 8033421 (1), 9500517 (1)
fmlp 32.9 1 10498622 (1)
phthalimide 32.6 4 7796053 (2), 8806743 (2)
n-formylmethionyl-leucylphenylalanine 29.6 1 10614782 (1)

Search CenterWatch for drugs/clinical trials and news about PRTN3 

Transcripts
for PRTN3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for PRTN3 gene: 
NM_002777.3  

Unigene Cluster for PRTN3:

Proteinase 3
Hs.928  [show with all ESTs]
Unigene Representative Sequence: FN647680
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000234347(uc002lqa.1) ENST00000544537(uc021umb.1)

miRNA
Products:     		 OriGene 3'-UTR Clone: PRTN3
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRTN3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PRTN3
SwitchGear 3'UTR luciferase reporter plasmid: PRTN3 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRTN3 (see all 7)
OriGene shRNA RFP: PRTN3
OriGene siRNA: PRTN3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRTN3
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRTN3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRTN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: PRTN3 (NM_002777)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRTN3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRTN3
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRTN3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRTN3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRTN3

Additional cDNA sequence: 

BC096183.1 BC096184.3 BC096185.3 BC096186.3 FN647680.1 M29142.1 M75154.1 X55668.1 
X56132.1 X56606.1 

1 DOTS entry:

DT.310571 

27 AceView cDNA sequences (see top 24):

BV199984 BP429701 BI029018 BV199994 X56606 BI029214 BV185512 BP428518 
X56132 BV199995 NM_002777 M75154 BE831590 X55668 BF893078 M29142 
AI273534 BP428468 BF898648 BQ335282 BI026807 AW966814 BI028421 T85543 
D19823 T85544 R94365 

GeneLoc Exon Structure


Expression
for PRTN3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRTN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

PRTN3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See PRTN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRTN3

SOURCE GeneReport for Unigene cluster: Hs.928
    SABiosciences Expression via Pathway-Focused PCR Array including PRTN3: 
          Antibacterial Response in human mouse rat

Primer
Products:		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRTN3
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRTN3
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRTN3
In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PRTN3

Orthologs
for PRTN3 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for PRTN3 gene from 2/13 species (see all 13)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
zebrafish
(Danio rerio)		 Actinopterygii CR558302.26
AL954146.16
 --
 31(a)
31(a)
 possible ortholog
possible ortholog
 11(3640652-3646662)
23(37542555-37552094)
fruit fly
(Drosophila melanogaster)		 Insecta CG169986
CG328086
(see all 49)		 --
 27(a)
27(a)
(see all 49)		 possible ortholog
possible ortholog
(see all 49)		 3L(7532160-7532936)
X(1362763-1363679)


ENSEMBL Gene Tree for PRTN3 (if available)
TreeFam Gene Tree for PRTN3 (if available) 

Paralogs
for PRTN3 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for PRTN3 gene
GZMH2  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  AZU12  
GZMM2  GZMA2  GZMB2  
18/61 SIMAP similar genes for PRTN3 using alignment to 2 protein entries:     PRTN3_HUMAN (see all proteins) (see all similar genes):
ELANE    ELA2    AZU1    PRSS1    CTSG    CMA1
PRSS2    TRY6    TRY8    PRSS3    CTRL    GZMK
KLK4    DF    LPA    CFD    APS    KLK6

PRTN3 for paralogs           About GeneDecksing



Genomic Variants
for PRTN3 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/253 NCBI SNPs in PRTN3 are shown (see all 253)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 19 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1492124241,2
--839030(+) ATGGGC/TTTCGA 1 -- us2k10--------
rs1432557671,2
--839070(+) CGCCCA/GGGACT 1 -- us2k10--------
rs739198631,2
C,F,--839097(+) GAGGCC/AACCCA 1 -- us2k13Minor allele frequency- A:0.07WA CSA 122
rs1482964801,2
--839147(+) CAGCTC/GTCCTC 1 -- us2k10--------
rs120521081,2
C,F,A,H,--839158(+) AATGGC/TCCCAA 1 -- us2k122Minor allele frequency- T:0.18NS EA NA WA CSA 2347
rs1405230041,2
--839189(+) GACTGA/CGCCCG 1 -- us2k10--------
rs793612211,2
--839193(+) GCGCCC/GGCTGG 1 -- us2k10--------
rs1380321111,2
--839269(+) ATACTC/TAGGGG 1 -- us2k10--------
rs104108261,2
C,F,--839272(+) CTCAGG/TGGGCT 1 -- us2k14Minor allele frequency- T:0.23NA WA CSA 124
rs621322941,2
C,--839298(+) ATTTGG/CAATCA 1 -- us2k13Minor allele frequency- C:0.18NA EA 242

HapMap Linkage Disequilibrium report for PRTN3 (840974 - 848180 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PRTN3
     2 CNVs: 30054 30052

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRTN3
DNA2.0 Custom Variant and Variant Library Synthesis for PRTN3

Disorders / Diseases
for PRTN3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
PRTN3 for disorders           About GeneDecksing

OMIM gene information: 177020    OMIM disorders: --

20/88 diseases for PRTN3 (see all 88):    About MalaCards
wegener's granulomatosis    alpha 1-antitrypsin deficiency    churg-strauss syndrome    mononeuritis multiplex
subacute bacterial endocarditis    mixed connective tissue disease    polyarteritis nodosa    connective tissue disease
mononeuritis    hypersensitivity reaction type ii disease    rapidly progressive glomerulonephritis    microscopic polyangiitis
pyoderma gangrenosum    graft versus host disease    sclerosing cholangitis    relapsing polychondritis
primary sclerosing cholangitis    inflammatory bowel disease    myeloid leukemia    cholangitis

11 diseases from the University of Copenhagen DISEASES database for PRTN3:
Vasculitis     Hypersensitivity reaction type II disease     Glomerulonephritis     Rheumatoid arthritis
Polyarteritis nodosa     Scleritis     Sinusitis     Connective tissue disease
Inflammatory bowel disease     Endocarditis     Kidney failure

10/81 Novoseek disease relationships for PRTN3 gene (see all 81)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
wegeners granulomatosis 96.5 304 8157982 (3), 15498036 (3), 17005932 (3), 19881350 (3) (see all 99)
vasculitis 92.8 228 12605707 (4), 16792675 (4), 15958084 (3), 8499060 (2) (see all 99)
churg-strauss syndrome 85.5 15 12687504 (1), 17521322 (1), 10896971 (1), 8381764 (1) (see all 10)
glomerulonephritis 81.1 20 10405206 (2), 10844589 (1), 11034396 (1), 11092351 (1) (see all 14)
glomerulonephritis rapidly progressive 78.9 2 7847352 (1), 9306336 (1)
vasculitis leukocytoclastic 71.9 8 7626983 (1), 7554378 (1), 11838849 (1), 11208991 (1) (see all 6)
polyarteritis nodosa 64.4 6 7754755 (2), 7907475 (1)
pulmonary hemorrhage 57.2 1 1351955 (1)
inflammation 55.5 43 10101005 (2), 7829874 (1), 10471824 (1), 11272269 (1) (see all 28)
autoimmune diseases 55.2 8 14736010 (1), 10720938 (1), 16026591 (1), 18953353 (1) (see all 7)

Genetic Association Database (GAD): PRTN3
Human Genome Epidemiology (HuGE) Navigator: PRTN3 (7 documents)

Export disorders for PRTN3 gene to outside databases

Publications
for PRTN3 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PRTN3 gene, integrated from 9 sources (see all 664):
(articles sorted by number of sources associating them with PRTN3)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. (PubMed id 2258701)1, 2, 3, 9 Campanelli D....Gabay J.E. (1990)
  2. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. (PubMed id 2033050)1, 2, 9 Rao N.V....Hoidal J.R. (1991)
  3. Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. (PubMed id 1400430)1, 2, 9 Sturrock A.B.... Hoidal J.R. (1992)
  4. Proteinase 3 gene polymorphisms and Wegener's granulomatosis. (PubMed id 11115080)1, 4, 9 Gencik M....Fricke H. (2000)
  5. Wegener autoantigen and myeloblastin are encoded by a single mRNA. (PubMed id 1681549)1, 2, 9 Labbaye C.... Cayre Y.E. (1991)
  6. Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme. (PubMed id 2121162)1, 2, 9 Ohlsson K.... Rosengren M. (1990)
  7. The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. (PubMed id 8757293)1, 2, 9 Fujinaga M.... James M.N.G. (1996)
  8. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PubMed id 1518849)1, 2, 9 Zimmer M....Jenne D.E. (1992)
  9. Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia. (PubMed id 9924693)1, 2, 9 Clave E.... Barrett A.J. (1999)
  10. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. (PubMed id 1688612)1, 2, 9 Ludemann J.... Gross W.L. (1990)

External Searches for PRTN3 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing PRTN3 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5657 HGNC: 9495 AceView: PRTN3 Ensembl:ENSG00000196415 euGenes: HUgn5657
ECgene: PRTN3 H-InvDB: PRTN3

Other Databases showing PRTN3 gene

(According to HUGE)
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Specialized Databases showing PRTN3 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PRTN3 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Proteinase_3

Intellectual Property
for PRTN3 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PRTN3 gene:
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