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PRTN3 Gene

protein-coding   GIFtS: 62
GCID: GC19P000840

Proteinase 3

  See PRTN3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteinase 31 2     C-ANCA Antigen2 3
AGP72 3 5     neutrophil1
myeloblastin1 2     Serine Proteinase1
Wegener Granulomatosis Autoantigen1 2     ACPA2
Leukocyte Proteinase 32 3     C-ANCA2
Neutrophil Proteinase 42 3     CANCA2
Wegener Autoantigen2 3     MBT2
MBN2 3     NP42
NP-42 3     Azurophil Granule Protein 72
P292 3     Serine Proteinase, Neutrophil2
PR-32 3     EC 3.4.21.763
PR32 3     EC 3.4.218

External Ids:    HGNC: 94951   Entrez Gene: 56572   Ensembl: ENSG000001964157   OMIM: 1770205   UniProtKB: P241583   

Export aliases for PRTN3 gene to outside databases

Previous GC identifers: GC19P000922 GC19P000910 GC19P000780 GC19P000793 GC19P000498 GC19P000794 GC19P000610


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRTN3 Gene:
PRTN3 (proteinase 3) is a protein-coding gene. Diseases associated with PRTN3 include wegener's granulomatosis, and subacute bacterial endocarditis. GO annotations related to this gene include serine-type peptidase activity and enzyme binding. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin,
and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to
hamsters

Gene Wiki entry for PRTN3 (Proteinase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  NT_187622.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRTN3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRTN3 promoter sequence
   Search Chromatin IP Primers for PRTN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PRTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRTN3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000840:  view genomic region     (about GC identifiers)

Start:
840,963 bp from pter      End:
848,175 bp from pter
Size:
7,213 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158 (See protein sequence)
Recommended Name: Myeloblastin precursor  
Size: 256 amino acids; 27807 Da
Sequence caution: Sequence=AAA36342.1; Type=Frameshift; Positions=34, 39; Sequence=CAA39598.1; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for PRTN3:
1FUJ (3D)    
Secondary accessions: P15637 P18078 Q4VB08 Q4VB09 Q6LBM7 Q6LBN2 Q9UD25 Q9UQD8

Explore the universe of human proteins at neXtProt for PRTN3: NX_P24158

Explore proteomics data for PRTN3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn129, Asn174
  • Selected DME Specific Peptides for PRTN3 (P24158) (see all 5)
     GDSGGPL  SGGPLIC  VLTAAHC  PHSRPYMA 


    See PRTN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002768.3  
    ENSEMBL proteins: 
     ENSP00000234347   ENSP00000475174  

    PRTN3 Human Recombinant Protein Products:

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    Novus Biologicals PRTN3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PRTN3
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRTN3 

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for PRTN3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P24158

    ProtoNet protein and cluster: P24158

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
    Similarity: Belongs to the peptidase S1 family. Elastase subfamily
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PRTN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRTN3_HUMAN, P24158
    Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin,
    and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to
    hamsters
    Catalytic activity: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- -Xaa- > -Val- -Xaa-

         Genatlas biochemistry entry for PRTN3:
    proteinase 3,myeloblastin,Wegener autoantigen,responsive to CSF3,stimulated by SPI1,MYB,inducing factor
    independent growth of hematopoietic cells

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.761

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS2679910
    GO:0019899enzyme binding IPI17712045
         
    Find genes that share ontologies with PRTN3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRTN3:
     Decreased viability  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prtn3):
     hematopoietic system  immune system 

    Find genes that share phenotypes with PRTN3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Elane/Prtn3Elane/tm1Deje for PRTN3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRTN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRTN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRTN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRTN3

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    Predesigned siRNA for gene silencing in human, mouse, rat PRTN3

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    GenScript: all cDNA clones in your preferred vector: PRTN3 (NM_002777)
    Sino Biological Human cDNA Clone for PRTN3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5
    extracellular3
    lysosome3
    vacuole3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA17712045
    GO:0005886plasma membrane IDA17712045
    GO:0031012colocalizes with extracellular matrix IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PRTN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRTN3 About    
    See pathways by source

    SuperPathContained pathways About
    1C-MYB transcription factor network
    C-MYB transcription factor network


    1 BioSystems Pathway for PRTN3
        C-MYB transcription factor network



        Pathway & Disease-focused RT2 Profiler PCR Array including PRTN3: 
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRTN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for PRTN3 (P241582, 3 ENSP000002343474) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0008284positive regulation of cell proliferation TAS2598267
    GO:0030574collagen catabolic process IEA--
    GO:0050765negative regulation of phagocytosis IDA17712045
    GO:0097029mature dendritic cell differentiation IDA16478888

    Find genes that share ontologies with PRTN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PRTN3
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRTN3

    Selected Novoseek inferred chemical compound relationships for PRTN3 gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 75.5 224 2033050 (4), 1400430 (3), 11272267 (3), 1681549 (3) (see all 99)
    propylthiouracil 63.2 5 10025935 (1), 8103148 (1), 17350787 (1), 17161817 (1)
    acpa 58.3 5 1316247 (1), 2240162 (1), 1656761 (1), 1688612 (1)
    sulf 55.6 3 7586784 (1), 7612152 (1)
    aebsf 53.6 1 12354776 (1)
    3,4-dichloroisocoumarin 50.6 4 14525961 (1), 9067256 (1), 1551417 (1)
    pmsf 40.3 5 12960243 (1), 8033421 (1), 9500517 (1)
    fmlp 32.9 1 10498622 (1)
    phthalimide 32.6 4 7796053 (2), 8806743 (2)
    n-formylmethionyl-leucylphenylalanine 29.6 1 10614782 (1)



    Find genes that share compounds with PRTN3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRTN3 gene: 
    NM_002777.3  

    Unigene Cluster for PRTN3:

    Proteinase 3
    Hs.928  [show with all ESTs]
    Unigene Representative Sequence: FN647680
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234347(uc002lqa.1) ENST00000544537(uc021umb.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PRTN3
      QuantiFast Probe-based Assays in human, mouse, rat PRTN3

    Additional mRNA sequence: 

    BC096183.1 BC096184.3 BC096185.3 BC096186.3 FN647680.1 M29142.1 M75154.1 X55668.1 
    X56132.1 X56606.1 

    1 DOTS entry:

    DT.310571 

    27 AceView cDNA sequences (see top 24):

    BV185512 BV199984 BV199995 X56606 BP428518 BI029018 BP429701 BI029214 
    BV199994 X56132 BP428468 BF893078 NM_002777 X55668 M75154 M29142 
    BE831590 AI273534 BF898648 BQ335282 BI026807 AW966814 BI028421 D19823 
    T85543 T85544 R94365 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRTN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRTN3 Expression
    About this image


    PRTN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 8 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone marrow-derived hematopoietic stem cells (family)
             Bone Marrow CD34+ Cells   
             bone marrow mononuclear cells   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             bone marrow   
     
     Liver (Hepatobiliary System)
             Fetal Liver CD34+ Cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    PRTN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRTN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.928
        Pathway & Disease-focused RT2 Profiler PCR Array including PRTN3: 
              Antibacterial Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRTN3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prtn31 , 5 proteinase 31, 5 73.19(n)1
    68(a)1
      10 (39.72 cM)5
    191521  NM_011178.21  NP_035308.21 
     798744765 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prtn31 proteinase 3 55.61(n)
    52.8(a)
      448597  NM_001006846.1  NP_001006847.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0071421 AgaP_AGAP007142 47.76(n)
    38.94(a)
      1269964  XM_308619.3  XP_308619.3 


    ENSEMBL Gene Tree for PRTN3 (if available)
    TreeFam Gene Tree for PRTN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRTN3 gene
    GZMH2  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  AZU12  
    GZMM2  GZMA2  GZMB2  
    Selected SIMAP similar genes for PRTN3 using alignment to 3 protein entries:     PRTN3_HUMAN (see all proteins) (see all similar genes):
    ELANE    ELA2    AZU1    PRSS1    CTSG    CMA1
    PRSS2    TRY8    PRSS3    CTRL    GZMK    LPA
    KLK4    DF    KLK6    APS    CFD    CELA3A

    Find genes that share paralogs with PRTN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRTN3 (see all 334)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492124241,2
    --839030(+) ATGGGC/TTTCGA 1 -- us2k10--------
    rs1432557671,2
    --839070(+) CGCCCA/GGGACT 1 -- us2k10--------
    rs739198631,2
    C,F--839097(+) GAGGCC/AACCCA 1 -- us2k13Minor allele frequency- A:0.07WA CSA 122
    rs1482964801,2
    C--839147(+) CAGCTC/GTCCTC 1 -- us2k10--------
    rs120521081,2
    C,F,A,H--839158(+) AATGGC/TCCCAA 1 -- us2k122Minor allele frequency- T:0.18NS EA NA WA CSA 2347
    rs1405230041,2
    --839189(+) GACTGA/CGCCCG 1 -- us2k10--------
    rs793612211,2
    F--839193(+) GCGCCC/GGCTGG 1 -- us2k10--------
    rs1380321111,2
    --839269(+) ATACTC/TAGGGG 1 -- us2k10--------
    rs104108261,2
    C,F--839272(+) CTCAGG/TGGGCT 1 -- us2k14Minor allele frequency- T:0.23NA WA CSA 124
    rs621322941,2
    C,F--839298(+) ATTTGG/CAATCA 1 -- us2k13Minor allele frequency- C:0.18NA EA 242

    HapMap Linkage Disequilibrium report for PRTN3 (840963 - 848175 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRTN3 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717797CNV Deletion23290073
    esv2717798CNV Deletion23290073
    nsv470101CNV Loss18288195
    dgv3550n71CNV Loss21882294
    nsv910292CNV Loss21882294
    nsv138320CNV Loss16902084
    dgv3558n71CNV Loss21882294
    dgv3555n71CNV Loss21882294
    dgv3552n71CNV Loss21882294
    dgv3554n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 177020    OMIM disorders: --

    14 diseases for PRTN3:    
    About MalaCards
    wegener's granulomatosis    subacute bacterial endocarditis    mononeuritis multiplex    mononeuritis
    mononeuropathy    scleritis    rapidly progressive glomerulonephritis    alpha 1-antitrypsin deficiency
    vasculitis    polyarteritis nodosa    dysphagia    glomerulonephritis
    primary sclerosing cholangitis    chronic myeloid leukemia

    12 diseases from the University of Copenhagen DISEASES database for PRTN3:
    Vasculitis     Hypersensitivity reaction type II disease     Glomerulonephritis     Rheumatoid arthritis
    Polyarteritis nodosa     Scleritis     Sinusitis     Connective tissue disease
    Endocarditis     Ulcerative colitis     Lung disease     Mononeuropathy

    Find genes that share disorders with PRTN3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRTN3 gene (see all 81)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wegeners granulomatosis 96.5 304 8157982 (3), 15498036 (3), 17005932 (3), 19881350 (3) (see all 99)
    vasculitis 92.8 228 12605707 (4), 16792675 (4), 15958084 (3), 8499060 (2) (see all 99)
    churg-strauss syndrome 85.5 15 12687504 (1), 17521322 (1), 10896971 (1), 8381764 (1) (see all 10)
    glomerulonephritis 81.1 20 10405206 (2), 10844589 (1), 11034396 (1), 11092351 (1) (see all 14)
    glomerulonephritis rapidly progressive 78.9 2 7847352 (1), 9306336 (1)
    vasculitis leukocytoclastic 71.9 8 7626983 (1), 7554378 (1), 11838849 (1), 11208991 (1) (see all 6)
    polyarteritis nodosa 64.4 6 7754755 (2), 7907475 (1)
    pulmonary hemorrhage 57.2 1 1351955 (1)
    inflammation 55.5 43 10101005 (2), 7829874 (1), 10471824 (1), 11272269 (1) (see all 28)
    autoimmune diseases 55.2 8 14736010 (1), 10720938 (1), 16026591 (1), 18953353 (1) (see all 7)

    Genetic Association Database (GAD): PRTN3
    Human Genome Epidemiology (HuGE) Navigator: PRTN3 (7 documents)

    Export disorders for PRTN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRTN3 gene, integrated from 10 sources (see all 670):
    (articles sorted by number of sources associating them with PRTN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. (PubMed id 2258701)1, 2, 3, 9 Campanelli D....Gabay J.E. (J. Exp. Med. 1990)
    2. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. (PubMed id 2033050)1, 2, 9 Rao N.V....Hoidal J.R. (J. Biol. Chem. 1991)
    3. Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. (PubMed id 1400430)1, 2, 9 Sturrock A.B.... Hoidal J.R. (J. Biol. Chem. 1992)
    4. Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism. (PubMed id 16792675)1, 4, 9 Abdgawad M....Segelmark M. (Clin. Exp. Immunol. 2006)
    5. Proteinase 3 gene polymorphisms and Wegener's granulomatosis. (PubMed id 11115080)1, 4, 9 Gencik M....Fricke H. (Kidney Int. 2000)
    6. Wegener autoantigen and myeloblastin are encoded by a single mRNA. (PubMed id 1681549)1, 2, 9 Labbaye C.... Cayre Y.E. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    7. Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme. (PubMed id 2121162)1, 2, 9 Ohlsson K.... Rosengren M. (Biol. Chem. Hoppe-Seyler 1990)
    8. The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. (PubMed id 8757293)1, 2, 9 Fujinaga M.... James M.N.G. (J. Mol. Biol. 1996)
    9. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PubMed id 1518849)1, 2, 9 Zimmer M....Jenne D.E. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    10. Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia. (PubMed id 9924693)1, 2, 9 Clave E.... Barrett A.J. (J. Immunother. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5657 HGNC: 9495 AceView: PRTN3 Ensembl:ENSG00000196415 euGenes: HUgn5657
    ECgene: PRTN3 H-InvDB: PRTN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRTN3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Proteinase_3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRTN3 gene:
    Search GeneIP for patents involving PRTN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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