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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRTN3 Gene

protein-coding   GIFtS: 61
GCID: GC19P000840

Proteinase 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proteinase 31 2     C-ANCA Antigen2 3
AGP72 3 5     neutrophil1
myeloblastin1 2     Serine Proteinase1
Wegener Granulomatosis Autoantigen1 2     ACPA2
Leukocyte Proteinase 32 3     C-ANCA2
Neutrophil Proteinase 42 3     CANCA2
Wegener Autoantigen2 3     MBT2
MBN2 3     NP42
NP-42 3     Azurophil Granule Protein 72
P292 3     Serine Proteinase, Neutrophil2
PR-32 3     EC 3.4.21.763
PR32 3     EC 3.4.218

External Ids:    HGNC: 94951   Entrez Gene: 56572   Ensembl: ENSG000001964157   OMIM: 1770205   UniProtKB: P241583   

Export aliases for PRTN3 gene to outside databases

Previous GC identifers: GC19P000922 GC19P000910 GC19P000780 GC19P000793 GC19P000498 GC19P000794 GC19P000610


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PRTN3 Gene: 
PRTN3 (proteinase 3) is a protein-coding gene. Diseases associated with PRTN3 include wegener's granulomatosis, and subacute bacterial endocarditis. GO annotations related to this gene include serine-type peptidase activity and enzyme binding. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin,
and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to
hamsters

Gene Wiki entry for PRTN3 (Proteinase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRTN3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRTN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRTN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PRTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRTN3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000840:  view genomic region     (about GC identifiers)

Start:
840,963 bp from pter      End:
848,175 bp from pter
Size:
7,213 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158 (See protein sequence)
Recommended Name: Myeloblastin precursor  
Size: 256 amino acids; 27807 Da
Sequence caution: Sequence=AAA36342.1; Type=Frameshift; Positions=34, 39; Sequence=CAA39598.1; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for PRTN3:
1FUJ (3D)    
Secondary accessions: P15637 P18078 Q4VB08 Q4VB09 Q6LBM7 Q6LBN2 Q9UD25 Q9UQD8

Explore the universe of human proteins at neXtProt for PRTN3: NX_P24158

Explore proteomics data for PRTN3 at MOPED 

4/5 DME Specific Peptides for PRTN3 (P24158) (see all 5)
 GDSGGPL  SGGPLIC  VLTAAHC  PHSRPYMA 

PRTN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

PRTN3 Protein Expression
REFSEQ proteins: NP_002768.3  
ENSEMBL proteins: 
 ENSP00000234347   ENSP00000475174  

Human Recombinant Protein Products for PRTN3: 
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GenScript Custom Purified and Recombinant Proteins Services for PRTN3
Novus Biologicals PRTN3 Proteins
Novus Biologicals PRTN3 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for PRTN3
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol IDA17712045
GO:0005886plasma membrane IDA17712045
GO:0031012colocalizes with extracellular matrix IDA--

PRTN3 for ontologies           About GeneDecksing



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Assay Products for PRTN3: 
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P24158

ProtoNet protein and cluster: P24158

2 Blocks protein domains:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
Similarity: Belongs to the peptidase S1 family. Elastase subfamily
Similarity: Contains 1 peptidase S1 domain


PRTN3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PRTN3_HUMAN, P24158
Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin,
and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to
hamsters
Catalytic activity: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- -Xaa- > -Val- -Xaa-

     Genatlas biochemistry entry for PRTN3:
proteinase 3,myeloblastin,Wegener autoantigen,responsive to CSF3,stimulated by SPI1,MYB,inducing factor
independent growth of hematopoietic cells

     Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.761

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
GO:0005515protein binding ----
GO:0008236serine-type peptidase activity NAS--
GO:0019899enzyme binding IPI17712045
     
PRTN3 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for PRTN3:
 Decreased viability  Synthetic lethal with Ras 

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Prtn3):
 immune system 

PRTN3 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Elane/Prtn3Elane/tm1Deje for PRTN3

   inGenious Targeting Laboratory - Custom generated mouse model solutions for PRTN3 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRTN3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRTN3 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRTN3 

miRNA
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Inhib. RNA
Products:
    
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Gene Editing
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Clone
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OriGene ORF clones in mouse, rat for PRTN3
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GenScript: all cDNA clones in your preferred vector: PRTN3 (NM_002777)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3
Sirion Biotech Customized lentivirus for stable overexpression of PRTN3 
                     Customized lentivirus expression plasmids for stable overexpression of PRTN3 

Cell Line
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Search LifeMap BioReagents cell lines for PRTN3
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for PRTN3 About                                                                                                See pathways by source

SuperPathContained pathways About
1C-MYB transcription factor network
C-MYB transcription factor network


1 BioSystems Pathway for PRTN3
    C-MYB transcription factor network



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRTN3

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/58 Interacting proteins for PRTN3 (P241581, 2, 3 ENSP000002343474) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
InteractantInteraction Details
GeneCardExternal ID(s)
SMAD3P840221, 3, ENSP000003329734EBI-465028,EBI-347161 I2D: score=3 STRING: ENSP00000332973
TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
ENSG00000204490P013753I2D: score=1 
ENSG00000206439P013753I2D: score=1 
ENSG00000223952P013753I2D: score=1 
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--
GO:0008284positive regulation of cell proliferation TAS2598267
GO:0030574collagen catabolic process IEA--
GO:0050765negative regulation of phagocytosis IDA17712045
GO:0097029mature dendritic cell differentiation IDA16478888

PRTN3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PRTN3 for compounds           About GeneDecksing

EMD Millipore small molecules for PRTN3:
Small Molecule - inhibitor
Enzo Life Sciences drugs & compounds for PRTN3

Browse Tocris compounds for PRTN3

10/44 Novoseek inferred chemical compound relationships for PRTN3 gene (see all 44)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
serine 75.5 224 2033050 (4), 1400430 (3), 11272267 (3), 1681549 (3) (see all 99)
propylthiouracil 63.2 5 10025935 (1), 8103148 (1), 17350787 (1), 17161817 (1)
acpa 58.3 5 1316247 (1), 2240162 (1), 1656761 (1), 1688612 (1)
sulf 55.6 3 7586784 (1), 7612152 (1)
aebsf 53.6 1 12354776 (1)
3,4-dichloroisocoumarin 50.6 4 14525961 (1), 9067256 (1), 1551417 (1)
pmsf 40.3 5 12960243 (1), 8033421 (1), 9500517 (1)
fmlp 32.9 1 10498622 (1)
phthalimide 32.6 4 7796053 (2), 8806743 (2)
n-formylmethionyl-leucylphenylalanine 29.6 1 10614782 (1)

Search CenterWatch for drugs/clinical trials and news about PRTN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRTN3 gene: 
NM_002777.3  

Unigene Cluster for PRTN3:

Proteinase 3
Hs.928  [show with all ESTs]
Unigene Representative Sequence: FN647680
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000234347(uc002lqa.1) ENST00000544537(uc021umb.1)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PRTN3
SwitchGear 3'UTR luciferase reporter plasmidPRTN3 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for PRTN3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRTN3
Clone
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OriGene ORF clones in mouse, rat for PRTN3
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GenScript: all cDNA clones in your preferred vector: PRTN3 (NM_002777)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRTN3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3
Sirion Biotech Customized lentivirus for stable overexpression of PRTN3 
                     Customized lentivirus expression plasmids for stable overexpression of PRTN3 
Primer
Products:
    
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRTN3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRTN3

Additional mRNA sequence: 

BC096183.1 BC096184.3 BC096185.3 BC096186.3 FN647680.1 M29142.1 M75154.1 X55668.1 
X56132.1 X56606.1 

1 DOTS entry:

DT.310571 

24/27 AceView cDNA sequences (see all 27):

BV199984 BI029214 X56606 BV199995 X56132 BV185512 BI029018 BV199994 
BP428518 BP429701 AI273534 M29142 BP428468 NM_002777 X55668 BF893078 
M75154 BE831590 BF898648 AW966814 BQ335282 BI026807 BI028421 T85543 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRTN3 expression in normal human tissues (normalized intensities)      PRTN3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
PRTN3 Expression
About this image


PRTN3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 7 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
         Bone marrow-derived hematopoietic stem cells
         Bone Marrow CD34+ Cells   
         bone marrow mononuclear cells   
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone Marrow
         bone marrow   
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 Liver (Hepatobiliary System)
         Fetal Liver CD34+ Cells   

See PRTN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRTN3

SOURCE GeneReport for Unigene cluster: Hs.928
    SABiosciences Expression via Pathway-Focused PCR Array including PRTN3: 
          Antibacterial Response in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRTN3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PRTN3 gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Prtn31 , 5 proteinase 31, 5 70.92(n)1
65.74(a)1
  10 (39.72 cM)5
191521  NM_011178.21  NP_035308.21 
 798744765 
zebrafish
(Danio rerio)
Actinopterygii si:dkey-21e2.106
si:dkey-21e2.76
(see all 25)
si:dkey-21e2.7
(see all 25)
34(a)
34(a)
(see all 25)
possible ortholog
possible ortholog
(see all 25)
22(19565584-19569063)
22(19537137-19539386)
fruit fly
(Drosophila melanogaster)
Insecta CG328086
CG167496
(see all 3)
--
28(a)
28(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
X(1362763-1363679)
3R(5156607-5157617)


ENSEMBL Gene Tree for PRTN3 (if available)
TreeFam Gene Tree for PRTN3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for PRTN3 gene
GZMH2  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  AZU12  
GZMM2  GZMA2  GZMB2  
18/53 SIMAP similar genes for PRTN3 using alignment to 2 protein entries:     PRTN3_HUMAN (see all proteins) (see all similar genes):
ELANE    ELA2    AZU1    PRSS1    CTSG    CMA1
PRSS2    TRY6    TRY8    PRSS3    CTRL    GZMK
KLK4    DF    LPA    CFD    APS    KLK6

PRTN3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/334 SNPs in PRTN3 are shown (see all 334)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1492124241,2
--839030(+) ATGGGC/TTTCGA 1 -- us2k10--------
rs1432557671,2
--839070(+) CGCCCA/GGGACT 1 -- us2k10--------
rs739198631,2
C,F--839097(+) GAGGCC/AACCCA 1 -- us2k13Minor allele frequency- A:0.07WA CSA 122
rs1482964801,2
C--839147(+) CAGCTC/GTCCTC 1 -- us2k10--------
rs120521081,2
C,F,A,H--839158(+) AATGGC/TCCCAA 1 -- us2k122Minor allele frequency- T:0.18NS EA NA WA CSA 2347
rs1405230041,2
--839189(+) GACTGA/CGCCCG 1 -- us2k10--------
rs793612211,2
F--839193(+) GCGCCC/GGCTGG 1 -- us2k10--------
rs1380321111,2
--839269(+) ATACTC/TAGGGG 1 -- us2k10--------
rs104108261,2
C,F--839272(+) CTCAGG/TGGGCT 1 -- us2k14Minor allele frequency- T:0.23NA WA CSA 124
rs621322941,2
C,F--839298(+) ATTTGG/CAATCA 1 -- us2k13Minor allele frequency- C:0.18NA EA 242

HapMap Linkage Disequilibrium report for PRTN3 (840963 - 848175 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/21 variations for PRTN3 (see all 21):    About this table     
Variant IDTypeSubtypePubMed ID
esv2717797CNV Deletion23290073
esv2717798CNV Deletion23290073
nsv470101CNV Loss18288195
dgv3550n71CNV Loss21882294
nsv910292CNV Loss21882294
nsv138320CNV Loss16902084
dgv3558n71CNV Loss21882294
dgv3555n71CNV Loss21882294
dgv3552n71CNV Loss21882294
dgv3554n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 177020    OMIM disorders: --

20/87 diseases for PRTN3 (see all 87):    About MalaCards
wegener's granulomatosis    subacute bacterial endocarditis    mononeuritis multiplex    mononeuritis
mononeuropathy    rapidly progressive glomerulonephritis    alpha 1-antitrypsin deficiency    endocarditis
scleritis    vasculitis    crescentic glomerulonephritis    churg-strauss syndrome
mixed connective tissue disease    relapsing polychondritis    polyarteritis nodosa    microscopic polyangiitis
cholangitis    glomerulonephritis    pyoderma    pyoderma gangrenosum

12 diseases from the University of Copenhagen DISEASES database for PRTN3:
Vasculitis     Hypersensitivity reaction type II disease     Glomerulonephritis     Rheumatoid arthritis
Polyarteritis nodosa     Scleritis     Sinusitis     Connective tissue disease
Endocarditis     Ulcerative colitis     Lung disease     Mononeuropathy

PRTN3 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/81 Novoseek inferred disease relationships for PRTN3 gene (see all 81)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
wegeners granulomatosis 96.5 304 8157982 (3), 15498036 (3), 17005932 (3), 19881350 (3) (see all 99)
vasculitis 92.8 228 12605707 (4), 16792675 (4), 15958084 (3), 8499060 (2) (see all 99)
churg-strauss syndrome 85.5 15 12687504 (1), 17521322 (1), 10896971 (1), 8381764 (1) (see all 10)
glomerulonephritis 81.1 20 10405206 (2), 10844589 (1), 11034396 (1), 11092351 (1) (see all 14)
glomerulonephritis rapidly progressive 78.9 2 7847352 (1), 9306336 (1)
vasculitis leukocytoclastic 71.9 8 7626983 (1), 7554378 (1), 11838849 (1), 11208991 (1) (see all 6)
polyarteritis nodosa 64.4 6 7754755 (2), 7907475 (1)
pulmonary hemorrhage 57.2 1 1351955 (1)
inflammation 55.5 43 10101005 (2), 7829874 (1), 10471824 (1), 11272269 (1) (see all 28)
autoimmune diseases 55.2 8 14736010 (1), 10720938 (1), 16026591 (1), 18953353 (1) (see all 7)

Genetic Association Database (GAD): PRTN3
Human Genome Epidemiology (HuGE) Navigator: PRTN3 (7 documents)

Export disorders for PRTN3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for PRTN3 gene, integrated from 9 sources (see all 667) (see top 10):
(articles sorted by number of sources associating them with PRTN3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. (PubMed id 2258701)1, 2, 3, 9 Campanelli D....Gabay J.E. (1990)
  2. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. (PubMed id 2033050)1, 2, 9 Rao N.V....Hoidal J.R. (1991)
  3. Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. (PubMed id 1400430)1, 2, 9 Sturrock A.B.... Hoidal J.R. (1992)
  4. Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism. (PubMed id 16792675)1, 4, 9 Abdgawad M....Segelmark M. (2006)
  5. Proteinase 3 gene polymorphisms and Wegener's granulomatosis. (PubMed id 11115080)1, 4, 9 Gencik M....Fricke H. (2000)
  6. Wegener autoantigen and myeloblastin are encoded by a single mRNA. (PubMed id 1681549)1, 2, 9 Labbaye C.... Cayre Y.E. (1991)
  7. Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme. (PubMed id 2121162)1, 2, 9 Ohlsson K.... Rosengren M. (1990)
  8. The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. (PubMed id 8757293)1, 2, 9 Fujinaga M.... James M.N.G. (1996)
  9. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PubMed id 1518849)1, 2, 9 Zimmer M....Jenne D.E. (1992)
  10. Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia. (PubMed id 9924693)1, 2, 9 Clave E.... Barrett A.J. (1999)
  11. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. (PubMed id 1688612)1, 2, 9 Ludemann J.... Gross W.L. (1990)
  12. Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase. (PubMed id 2404977)1, 2, 9 Wilde C.G.... Scott R.W. (1990)
  13. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  14. Association study of Wegener granulomatosis and the functionally relevant A645G polymorphism in the bactericidal/permeability increasing protein (BPI) gene. (PubMed id 15686586)1, 4 Jagiello P....Epplen J.T. (2005)
  15. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  16. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
  17. Wegener's autoantigen and leukemia. (PubMed id 2001463)1, 2 Musette P....Kourilsky P. (1991)
  18. The relation of 29 kD C-ANCA antigen to proteinase 3. (PubMed id 2285532)1, 2 Goldschmeding R.... von dem Borne A.E. (1990)
  19. Wegener's autoantigen decoded. (PubMed id 2377228)1, 2 Jenne D.E.... Gross W.L. (1990)
  20. Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin. (PubMed id 2242436)1, 2 Gupta S.K.... Arnaout M.A. (1990)
  21. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells. (PubMed id 2598267)1, 2 Bories D.... Cayre Y.E. (1989)
  22. Antibiotic proteins of human polymorphonuclear leukocytes. (PubMed id 2501794)1, 2 Gabay J.E.... Nathan C.F. (1989)
  23. Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase. (PubMed id 2679910)1, 2 Niles J.L.... Arnaout M.A. (1989)
  24. Proteinase 3 is an IL-32 binding protein. (PubMed id 16488976)1, 9 Novick D....Kim S.H. (2006)
  25. Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis. (PubMed id 17712045)1, 9 Kantari C....Witko-Sarsat V. (2007)
  26. Interaction of proteinase 3 with CD11b/CD18 (beta2 integrin) on the cell membrane of human neutrophils. (PubMed id 12960243)1, 9 David A....Aviram I. (2003)
  27. Elastolysis by proteinase 3 and its inhibition by alpha(1)-proteinase inhibitor: a mechanism for the incomplete inhibition of ongoing elastolysis. (PubMed id 11867344)1, 9 Ying Q.L. and Simon S.R. (2002)
  28. Computational prediction of the binding site of proteinase 3 to the plasma membrane. (PubMed id 18076025)1, 9 Hajjar E....Reuter N. (2008)
  29. A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors. (PubMed id 18854317)1, 9 Korkmaz B....Jenne D.E. (2008)
  30. High PR3 or ELA2 expression by CD34+ cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects. (PubMed id 17412886)1, 9 Yong A.S....Barrett A.J. (2007)
  31. Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies. (PubMed id 15331626)1, 9 van Rossum A.P....Kallenberg C.G. (2004)
  32. Apoptosis-induced proteinase 3 membrane expression is independent from degranulation. (PubMed id 14525959)1, 9 Durant S....Witko-Sarsat V. (2004)
  33. Membrane expression of proteinase 3 is genetically determined. (PubMed id 12506139)1, 9 Schreiber A....Kettritz R. (2003)
  34. Cleavage of p21waf1 by proteinase-3, a myeloid-specific serine protease, potentiates cell proliferation. (PubMed id 12354776)1, 9 Witko-Sarsat V....Descamps-Latscha B. (2002)
  35. Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant. (PubMed id 12140766)1, 9 Wu C.H....Safa A.R. (2002)
  36. Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways. (PubMed id 12444202)1, 9 Preston G.A....Falk R.J. (2002)
  37. Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules. (PubMed id 10498622)1, 9 Witko-Sarsat V....Halbwachs-Mecarelli L. (1999)
  38. Neutrophil-derived proteinase 3 induces kallikrein-in dependent release of a novel vasoactive kinin. (PubMed id 19494315)1, 9 Kahn R....Karpman D. (2009)
  39. Human proteinase 3 (PR3) and its binding molecules: implications for inflammatory and PR3-related autoimmune responses. (PubMed id 17785293)1, 9 Muller A....Csernok E. (2007)
  40. Immune functions of proteinase 3. (PubMed id 16167885)1, 9 Sugawara S. (2005)
  41. Proteinase 3 sidesteps caspases and cleaves p21(Waf1/Cip1/Sdi1) to induce endothelial cell apoptosis. (PubMed id 14675038)1, 9 Pendergraft W.F....Preston G.A. (2004)
  42. Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis. (PubMed id 12191967)1, 9 Rarok A.A....Kallenberg C.G. (2002)
  43. Functional significance of Asn-linked glycosylation of proteinase 3 for enzymatic activity, processing, targeting, and recognition by anti-neutrophil cytoplasmic antibodies. (PubMed id 17158864)1, 9 Specks U....McDonald C.J. (2007)
  44. The presence of membrane Proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558. (PubMed id 15916759)1, 9 David A....Aviram I. (2005)
  45. Proteinase-3 induces procaspase-3 activation in the absence of apoptosis: potential role of this compartmentalized activation of membrane-associated procaspase-3 in neutrophils. (PubMed id 15879139)1, 9 Pederzoli M....Witko-Sarsat V. (2005)
  46. Proteinase-3 directly activates MMP-2 and degrades gelatin and Matrigel; differential inhibition by (-)epigallocatechin-3-gallate. (PubMed id 12832446)1, 9 Pezzato E....Garbisa S. (2003)
  47. Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts. (PubMed id 12538645)1, 9 Koehl C....Bieth J.G. (2003)
  48. Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates. (PubMed id 12114510)1, 9 Korkmaz B....Gauthier F. (2002)
  49. The proteinase 3 (PRTN3) gene is localized on 19p13.3 and is distal to the E2A gene. (PubMed id 8629812)1, 9 Le Coniat M. and Berger R. (1995)
  50. Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia. (PubMed id 12393722)1, 9 Burchert A....Neubauer A. (2003)
  51. Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. (PubMed id 10339575)1, 9 Coeshott C....Cheronis J. (1999)
  52. Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase. (PubMed id 18023421)1, 9 Hajjar E....Reuter N. (2007)
  53. Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase. A kinetic and molecular modeling analysis. (PubMed id 17088257)1, 9 Korkmaz B....Gauthier F. (2007)
  54. CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia. (PubMed id 12200377)1, 9 Scheibenbogen C....Keilholz U. (2002)
  55. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. (PubMed id 11389039)1, 9 Sorensen O.E....Borregaard N. (2001)
  56. Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis. (PubMed id 7897245)2, 9 Gaskin G.... Pusey C.D. (1995)
  57. Structures of human proteinase 3 and neutrophil elast ase--so similar yet so different. (PubMed id 20423453)1, 9 Hajjar E....Reuter N. (2010)
  58. Catalytic activity and inhibition of wegener antigen proteinase 3 on the cell surface of human polymorphonuclear neutrophils. (PubMed id 19447886)1, 9 Korkmaz B....Attucci S. (2009)
  59. Membrane-bound proteinase 3 and its receptors: releva nce for the pathogenesis of Wegener's Granulomatosis. (PubMed id 19185066)1, 9 Hu N....Kallenberg C.G. (2009)
  60. NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils. (PubMed id 17244676)1, 9 von Vietinghoff S....Kettritz R. (2007)
  61. Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway. (PubMed id 16478888)1, 9 Csernok E....Hellmich B. (2006)
  62. Membrane proteinase 3 and its interactions within microdomains of neutrophil membranes. (PubMed id 16598772)1, 9 Fridlich R....Aviram I. (2006)
  63. The N-terminal tetrapeptide of neutrophil proteinase 3 causes S-phase arrest in granulopoietic progenitors. (PubMed id 16263417)1, 9 Skold S....Olofsson T. (2005)
  64. Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis. (PubMed id 12010574)1, 9 Brockmann H....Mayet W. (2002)
  65. Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro. (PubMed id 8738804)1, 9 Berger S.P....Daha M.R. (1996)
  66. The phylogeny of proteinase 3/myeloblastin, the autoantigen in Wegener's granulomatosis, and myeloperoxidase as shown by immunohistochemical studies on human leukemic cell lines. (PubMed id 8261669)1, 9 Muller-Berat N....Wiik A. (1994)
  67. Neutrophil proteinase 3 acts on protease-activated rec eptor-2 to enhance vascular endothelial cell barrier function. (PubMed id 23202369)1 Kuckleburg C.J. and Newman P.J. (2013)
  68. Changes in proteinase 3 anti-neutrophil cytoplasm auto antibody levels in early systemic granulomatosis with polyangiitis (Wegener's) m ay reflect treatment rather than disease activity. (PubMed id 23380137)1 Rasmussen N....Jayne D.R. (2013)
  69. Proteinase 3, the autoantigen in granulomatosis with p olyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macr ophage phagocytosis, and promotes inflammation. (PubMed id 22844112)1 Gabillet J....Witko-Sarsat V. (2012)
  70. Expression profile of proinflammatory genes in neutrop hil-enriched granulocytes stimulated with native anti-PR3 autoantibodies. (PubMed id 22791638)1 Surmiak M....Sanak M. (2012)
  71. Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils. (PubMed id 22266279)1 Kuckleburg C.J....Newman P.J. (2012)
  72. Early plasma exchange improves outcome in PR3-ANCA-pos itive renal vasculitis. (PubMed id 22510451)1 Gregersen J.W....Ivarsen P. (2012)
  73. PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells. (PubMed id 22952809)1 Tull S.P....Savage C.O. (2012)
  74. Contradictory functions (activation/termination) of ne utrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity. (PubMed id 22270365)1 Bae S....Kim S. (2012)
  75. KRAS mutation is associated with elevated myeloblastin activity in human lung adenocarcinoma. (PubMed id 22210048)1 Wiedl T....Weder W. (2012)
  76. Proteinase 3 carries small unusual carbohydrates and a ssociates with alpha-defensins. (PubMed id 22138257)1 Zoega M....Schou C. (2012)
  77. Distinct proteinase 3-induced cytokine patterns in We generA's granulomatosis, Churg-Strauss syndrome, and healthy controls. (PubMed id 21470489)1 Fagin U....Lamprecht P. (2011)
  78. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
  79. Complement receptor Mac-1 is an adaptor for NB1 (CD17 7)-mediated PR3-ANCA neutrophil activation. (PubMed id 21193407)1 Jerke U....Kettritz R. (2011)
  80. Pulmonary proteases in the cystic fibrosis lung induc e interleukin 8 expression from bronchial epithelial cells via a heme/meprin/ep idermal growth factor receptor/Toll-like receptor pathway. (PubMed id 21193404)1 Cosgrove S....McElvaney N.G. (2011)
  81. Membrane-bound proteinase 3 and PAR2 mediate phagocyt osis of non-opsonized bacteria in human neutrophils. (PubMed id 21700341)1 Kim Y.C....Choi Y. (2011)
  82. Epitope shift of proteinase-3 anti-neutrophil cytopla smic antibodies in patients with small vessel vasculitis. (PubMed id 20059480)1 Selga D....Hellmark T. (2010)
  83. Mapping of conformational epitopes on human proteinas e 3, the autoantigen of Wegener's granulomatosis. (PubMed id 20530264)1 Kuhl A....Jenne D.E. (2010)
  84. Transcription of proteinase 3 and related myelopoiesi s genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis. (PubMed id 20155833)1 Cheadle C....Levine S.M. (2010)
  85. Natural autoantibodies to myeloperoxidase, proteinase 3, and the glomerular basement membrane are present in normal individuals. (PubMed id 20592714)1 Cui Z....Hellmark T. (2010)
  86. Neutrophil elastase and proteinase 3 trafficking rout es in myelomonocytic cells. (PubMed id 20828556)1 KAollquist L....Olsson I. (2010)
  87. Membrane proteinase 3 (mPR3) expression on neutrophil s is not increased in localized Wegener's granulomatosis (WG) and Churg-Strauss syndrome (CSS). (PubMed id 20412702)1 Holle J.U....Csernok E. (2010)
  88. Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression. (PubMed id 20491791)1 Abdgawad M....Hellmark T. (2010)
  89. The role of proteinase 3 (PR3) and the protease-activ ated receptor-2 (PAR-2) pathway in dendritic cell (DC) maturation of human-DC-l ike monocytes and murine DC. (PubMed id 20412704)1 Jiang B....Holle J.U. (2010)
  90. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
  91. Antineutrophil cytoplasmic antibody (ANCA) testing of routine sera varies in different laboratories but concordance is greater for c ytoplasmic fluorescence (C-ANCA) and myeloperoxidase specificity (MPO-ANCA). (PubMed id 19490915)1 Pollock W....Savige J. (2009)
  92. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
  93. ANCA patients have T cells responsive to complementary PR-3 antigen. (PubMed id 18596726)1 Yang J....Preston G.A. (2008)
  94. Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3. (PubMed id 17681950)1 Vong L....Perretti M. (2007)
  95. Antibodies to proteinase 3 prime human monocytic cells via protease-activated receptor-2 and NF-kappaB for Toll-like receptor- and NOD-dependent activation. (PubMed id 17452051)1 Uehara A....Takada H. (2007)
  96. Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis. (PubMed id 17534941)1 van der Helm-van Mil A.H....Toes R.E. (2007)
  97. Increased membrane expression of proteinase 3 during neutrophil adhesion in the presence of anti proteinase 3 antibodies. (PubMed id 17634439)1 Brachemi S....Halbwachs-Mecarelli L. (2007)
  98. Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site. (PubMed id 15975933)1 Dublet B....Witko-Sarsat V. (2005)
  99. Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. (PubMed id 15527767)1 Grimsby S....Souchelnytskyi S. (2004)
  100. Wegener's granulomatosis--autoimmunity to neutrophil proteinase 3. (PubMed id 12894870)1 Watorek E....Klinger M. (2003)
  101. Functional dissociation between proforms and mature forms of proteinase 3, azurocidin, and granzyme B in regulation of granulopoiesis. (PubMed id 12135665)1 Skold S....Olofsson T. (2002)
  102. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  103. Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). (PubMed id 12189154)1 Benarafa C....Remold-O'Donnell E. (2002)
  104. Human proteinase 3 can inhibits LPS-mediated TNF-alpha production through CD14 degradation: lack of influence of antineutrophil cytoplasmic antibodies. (PubMed id 12067299)1 Yard B.A....van der Woude F.J. (2002)
  105. Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. (PubMed id 11714826)1 Sugawara S....Takada H. (2001)
  106. Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry. (PubMed id 10978167)1 Loew D....Lanza F. (2000)
  107. Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family. (PubMed id 10512713)1 Abts H.F....Ruzicka T. (1999)
  108. Inhibitory properties of recombinant human monocyte/neutrophil elastase inhibitor. (PubMed id 7654387)1 Sugimori T....Remold-O'Donnell E. (1995)
  109. A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26). (PubMed id 7539799)2 Duke-Cohan J.S.... Schlossman S.F. (1995)
  110. Cytolytic effects of neutrophils: role for a membrane-bound neutral proteinase. (PubMed id 3513185)1 Pontremoli S....Horecker B.L. (1986)
  111. De novo synthesis of proteinase 3 by cytokine primed circulating human polymorphonuclear neutrophils and mononuclear cells. (PubMed id 11036837)9 Zhou Z....Menard H.A. (2000)
  112. Bioactive proteinase 3 on the cell surface of human neutrophils: quantification, catalytic activity, and susceptibility to inhibition. (PubMed id 10975855)9 Campbell E.J....Owen C.A. (2000)
  113. In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG). (PubMed id 11122262)9 van der Geld Y.M....Kallenberg C.G. (2000)
  114. Interaction of proteinase 3 with its associated partn ers: implications in the pathogenesis of Wegener's granulomatosis. (PubMed id 19881350)9 Witko-Sarsat V....Mouthon L. (2010)
  115. Glycosylation of proteinase 3 (PR3) is not required f or its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener' s granulomatosis. (PubMed id 19646346)9 Finkielman J.D....Specks U. (2009)
  116. Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells. (PubMed id 8082300)9 Mayet W.J....Meyer zum Buschenfelde K.H. (1994)
  117. Rats and mice immunised with chimeric human/mouse proteinase 3 produce autoantibodies to mouse Pr3 and rat granulocytes. (PubMed id 17644551)9 van der Geld Y.M....Kallenberg C.G. (2007)
  118. Proteinase 3, Wegener's autoantigen: from gene to antigen. (PubMed id 11272267)9 van der Geld Y.M....Kallenberg C.G. (2001)
  119. Interaction of purified human proteinase 3 (PR3) with reconstituted lipid bilayers. (PubMed id 10103046)9 Goldmann W.H....Arnaout M.A. (1999)
  120. Leucocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis. (PubMed id 9734683)9 Muller Kobold A.C....Tervaert J.W. (1998)
  121. Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC? (PubMed id 8033421)9 Ballieux B.E....Daha M.R. (1994)
  122. Proteinase 3/myeloblastin as a growth factor in human kidney cells. (PubMed id 14736010)9 Relle M....Schwarting A. (2003)
  123. Proteinase 3 interacts with a 111-kD membrane molecule of human umbilical vein endothelial cells. (PubMed id 10752523)9 Taekema-Roelvink M.E....Daha M.R. (2000)
  124. A secreted proform of neutrophil proteinase 3 regulates the proliferation of granulopoietic progenitor cells. (PubMed id 9920833)9 Skold S....Olofsson T. (1999)
  125. Signal transduction pathways of membrane expression of proteinase 3 (PR-3) in human endothelial cells. (PubMed id 9395784)9 Mayet W.J....Meyer zum Buschenfelde K.H. (1997)
  126. Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis. (PubMed id 9187364)9 Jenne D.E....Specks U. (1997)
  127. Endothelial cells and renal epithelial cells do not express the Wegener's autoantigen, proteinase 3. (PubMed id 7554407)9 King W.J....Savage C.O. (1995)
  128. Measurements of proteinase 3 and its complexes with alpha 1-proteinase inhibitor and anti-neutrophil cytoplasm antibodies (ANCA) in plasma. (PubMed id 7930650)9 Baslund B....Wieslander J. (1994)
  129. Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing. (PubMed id 18462208)9 von Vietinghoff S....Kettritz R. (2008)
  130. Expression of recombinant proteinase 3, the autoantigen in Wegener's granulomatosis, in insect cells. (PubMed id 12191522)9 Van der Geld Y.M....Kallenberg C.G. (2002)
  131. ANCA antigens, proteinase 3 and myeloperoxidase, are not expressed in endothelial cells. (PubMed id 10792617)9 Pendergraft W.F....Preston G.A. (2000)
  132. Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2). (PubMed id 9925946)9 Sturrock A....Hoidal J.R. (1998)
  133. Human myeloblastin (leukocyte proteinase 3): reactions with substrates, inactivators and activators in comparison with leukocyte elastase. (PubMed id 9067256)9 Fruh H....Baici A. (1996)
  134. Proteinase 3 expression on neutrophil membranes from patients with infectious disease. (PubMed id 16878019)9 Matsumoto T....Kurosawa S. (2006)
  135. Human anti-neutrophil cytoplasm autoantibodies to proteinase 3 (PR3-ANCA) bind to neutrophils. (PubMed id 16014030)9 Van Rossum A.P....Kallenberg C.G. (2005)
  136. Proinflammatory cytokines induce proteinase 3 as membrane-bound and secretory forms in human oral epithelial cells and antibodies to proteinase 3 activate the cells through protease-activated receptor-2. (PubMed id 15356169)9 Uehara A....Sugawara S. (2004)
  137. Autoantibodies to neutrophil cytoplasmic antigens (ANCA) do not bind to polymorphonuclear neutrophils in blood. (PubMed id 15327394)9 Abdel-Salam B....Hansch G.M. (2004)
  138. Interference of PR3-ANCA with the enzymatic activity of PR3: differences in patients during active disease or remission of Wegener's granulomatosis. (PubMed id 12197900)9 van der Geld Y.M....Roos D. (2002)
  139. Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2. (PubMed id 12370398)9 Uehara A....Takada H. (2002)
  140. Proteinase 3 enhances endothelial monocyte chemoattractant protein-1 production and induces increased adhesion of neutrophils to endothelial cells by upregulating intercellular cell adhesion molecule-1. (PubMed id 11316851)9 Taekema-Roelvink M.E....Daha M.R. (2001)
  141. Kinetics of the inhibition of proteinase 3 by elafin. (PubMed id 11152654)9 Ying Q.L. and Simon S.R. (2001)
  142. Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum. (PubMed id 10101005)9 Witko-Sarsat V....Nadel J.A. (1999)
  143. Characterization of the processing and granular targeting of human proteinase 3 after transfection to the rat RBL or the murine 32D leukemic cell lines. (PubMed id 9000544)9 Garwicz D....Gullberg U. (1997)
  144. Oxidized elafin and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3. (PubMed id 16279952)9 Nobar S.M....Bieth J.G. (2005)
  145. Design and use of highly specific substrates of neutrophil elastase and proteinase 3. (PubMed id 14693667)9 Korkmaz B....Gauthier F. (2004)
  146. Granulocyte-macrophage colony-stimulating factor (GM-CSF) but not granulocyte colony-stimulating factor (G-CSF) induces plasma membrane expression of proteinase 3 (PR3) on neutrophils in vitro. (PubMed id 10792393)9 Hellmich B....Ernst M. (2000)
  147. On the origin of surface proteinase 3 of nonmyeloid cells: evidence favoring an exogenous source. (PubMed id 11027458)9 Zhou Z....Menard H.A. (2000)
  148. Recombinant proteinase 3 produced in different expression systems: recognition by anti-PR3 antibodies. (PubMed id 11033024)9 van der Geld Y.M....Kallenberg C.G. (2000)
  149. Genomic organization and chromosomal localization of mouse proteinase 3 (Myeloblastin). (PubMed id 10051312)9 Belaaouaj A....Cayre Y. (1999)
  150. Proteinase 3 mRNA expression is induced in monocytes but not in neutrophils of patients with cystic fibrosis. (PubMed id 10471824)9 Just J....Cayre Y.E. (1999)
  151. Cytosine demethylation of the proteinase-3/myeloblastin primary granule protease gene during phagocyte development. (PubMed id 10482994)9 Lubbert M....Daskalakis M. (1999)
  152. Characterization of monoclonal antibodies to proteinase 3 (PR3) as candidate tools for epitope mapping of human anti-PR3 autoantibodies. (PubMed id 10594572)9 Van Der Geld Y.M....Kallenberg C.G. (1999)
  153. T cell reactivity to proteinase 3 and myeloperoxidase in patients with Wegener's granulomatosis (WG). (PubMed id 7994909)9 Brouwer E....Kallenberg C.G. (1994)
  154. Proteinase 3. A neutrophil proteinase with activity on platelets. (PubMed id 8157974)9 Renesto P....Chignard M. (1994)
  155. Release of immunoreactive human neutrophil proteinase 4, normally and in peritonitis. (PubMed id 1708522)9 Lundberg E....Ohlsson K. (1991)
  156. Generation of anti-proteinase 3 monoclonal antibodies and development of immunological methods to detect endogenous proteinase 3. (PubMed id 20199147)9 Bae S....Kim S. (2010)
  157. Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this en zyme in human serum. (PubMed id 20361767)9 Wysocka M....Rolka K. (2010)
  158. Increased monocyte transcription of the proteinase 3 gene in small vessel vasculitis. (PubMed id 15958084)9 Ohlsson S....Segelmark M. (2005)
  159. Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3. (PubMed id 14661018)9 Pendergraft W.F....Falk R.J. (2004)
  160. Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies-associated systemic vasculitis in remission. (PubMed id 12605707)9 Ohlsson S....Segelmark M. (2003)
  161. Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid. (PubMed id 11290610)9 Lutz P.G....Cayre Y.E. (2001)
  162. Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells. (PubMed id 10677505)9 Lutz P.G....Cayre Y.E. (2000)
  163. What you should know about PR3-ANCA. Conformational r equirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3 -ANCA. (PubMed id 11094439)9 Specks U. (2000)
  164. Capture-ELISA based on recombinant PR3 is sensitive for PR3-ANCA testing and allows detection of PR3 and PR3-ANCA/PR3 immunecomplexes. (PubMed id 9617836)9 Sun J....Specks U. (1998)
  165. A simple high yield procedure for purification of human proteinase 3, the main molecular target of cANCA. (PubMed id 9328566)9 Stummann L. and Wiik A. (1997)
  166. Characterization of a recombinant proteinase 3, the autoantigen in Wegener's granulomatosis and its reactivity with anti-neutrophil cytoplasmic autoantibodies. (PubMed id 8612734)9 Witko-Sarsat V....Gabay J.E. (1996)
  167. T cell responses to myeloperoxidase (MPO) and proteinase 3 (PR3) in patients with systemic vasculitis. (PubMed id 8565308)9 Griffith M.E....Pusey C.D. (1996)
  168. Biosynthesis and processing of proteinase 3 in U937 cells. Processing pathways are distinct from those of cathepsin G. (PubMed id 8621689)9 Rao N.V....Hoidal J.R. (1996)
  169. Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis. (PubMed id 7643521)9 Daouk G.H....Arnaout M.A. (1995)
  170. Characterization of monoclonal antibodies to proteinase-3 and application in the study of epitopes for classical anti-neutrophil cytoplasm antibodies. (PubMed id 8590038)9 Sommarin Y....Wieslander J. (1995)
  171. Structure of the azurocidin, proteinase 3, and neutrophil elastase genes. Implications for inflammation and vasculitis. (PubMed id 7952651)9 Jenne D.E. (1994)
  172. Detachment and cytolysis of human endothelial cells by proteinase 3. (PubMed id 7805749)9 Ballieux B.E....Daha M.R. (1994)
  173. Epitopes on proteinase-3 recognized by antibodies from patients with Wegener's granulomatosis. (PubMed id 8157982)9 Williams R.C....Underwood D. (1994)
  174. Modulation of tissue factor and tissue factor pathway inhibitor-1 by neutrophil proteases. (PubMed id 19132232)9 Steppich B.A....Ott I. (2008)
  175. Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model. (PubMed id 15642667)9 Garwicz D....Lindmark A. (2005)
  176. Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor ONO-5046. (PubMed id 13679038)9 Suzuki K....Iwamoto I. (2003)
  177. Antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis after immunisation with bacterial proteins. (PubMed id 12508769)9 Savige J....MacGregor D. (2002)
  178. Neutrophil priming and apoptosis in anti-neutrophil cytoplasmic autoantibody-associated vasculitis. (PubMed id 11318943)9 Harper L....Savage C.O. (2001)
  179. Endothelial tissue factor stimulation by proteinase 3 and elastase. (PubMed id 11737080)9 Haubitz M....Brunkhorst R. (2001)
  180. Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants. (PubMed id 11159195)9 Yang J.J....Falk R.J. (2001)
  181. Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis. (PubMed id 11598905)9 Shamamian P....Mignatti P. (2001)
  182. Antineutrophil cytoplasmic antibodies (ANCAs) in patients with inflammatory bowel disease show no correlation with proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G and lysozyme: a Singapore study. (PubMed id 11269973)9 Ooi C.J....Ng H.S. (2000)
  183. Proteinase-3 mRNA expressed by glomerular epithelial cells correlates with crescent formation in Wegener's granulomatosis. (PubMed id 10844610)9 Schwarting A....Mayet W. (2000)
  184. Characterization of cDNA clones encoding mouse proteinase 3 (myeloblastine) and cathepsin G. (PubMed id 9211743)9 Aveskogh M....Hellman L. (1997)
  185. Inhibition of neutrophil elastase in CF sputum by L-658,758. (PubMed id 9399994)9 Rees D.D....Mumford R.A. (1997)
  186. Transforming growth factor-beta (TGF-beta) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. (PubMed id 8697616)9 Csernok E....Kekow J. (1996)
  187. Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa. (PubMed id 7907475)9 Henshaw T.J....Williams R.C. (1994)
  188. Interaction of secretory leukocyte protease inhibitor with proteinase-3. (PubMed id 8100709)9 Rao N.V....Hoidal J.R. (1993)
  189. Isolation of a protein complex from purulent sputum consisting of proteinase-3 and alpha 1-antitrypsin reactive with anti neutrophil cytoplasmic antibodies. (PubMed id 8445266)9 Ballieux B.E....Daha M.R. (1993)
  190. Cellular immune responses and pathogenesis in c-ANCA positive vasculitides. (PubMed id 8499060)9 Rasmussen N. and Petersen J. (1993)
  191. Impact of cyclins E, neutrophil elastase and proteinase 3 expression levels on clinical outcome in primary breast cancer patients. (PubMed id 16929516)9 Desmedt C....Sotiriou C. (2006)
  192. Inspection of the binding sites of proteinase3 for the design of a highly specific substrate. (PubMed id 16480262)9 Hajjar E....Reuter N. (2006)
  193. Major histocompatibility complex HLA region largely explains the genetic variance exercised on neutrophil membrane proteinase 3 expression. (PubMed id 17005932)9 von Vietinghoff S....Kettritz R. (2006)
  194. The - 564 A/G polymorphism in the promoter region of the proteinase 3 gene associated with Wegener's granulomatosis does not increase the promoter activity. (PubMed id 15498036)9 Pieters K....Hellmark T. (2004)
  195. A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis. (PubMed id 12422006)9 Csernok E....Gross W.L. (2002)
  196. Antigenic specificity of anti-neutrophil cytoplasmic antibody. (PubMed id 11265258)9 Fu H.L....Tsay G.J. (2001)
  197. The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18. (PubMed id 11035113)9 Kurosawa S....Stearns-Kurosawa D.J. (2000)
  198. Changes in chromatin organization at the neutrophil elastase locus associated with myeloid cell differentiation. (PubMed id 10572086)9 Wong E.T....Gilks C.B. (1999)
  199. A review of immunofluorescent patterns associated with antineutrophil cytoplasmic antibodies (ANCA) and their differentiation from other antibodies. (PubMed id 9828813)9 Savige J.A....Hendle M. (1998)
  200. A comprehensive method to purify three major ANCA antigens: proteinase 3, myeloperoxidase and bactericidal/permeability-increasing protein from human neutrophil granule acid extract. (PubMed id 8890899)9 Zhao M.H. and Lockwood C.M. (1996)
  201. Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners. (PubMed id 8894097)9 Groutas W.C....Prakash O. (1996)
  202. Regulation of myeloblastin messenger RNA expression in myeloid leukemia cells treated with all-trans retinoic acid. (PubMed id 8422465)9 Labbaye C....Cayre Y.E. (1993)
  203. Correlation of antineutrophil cytoplasmic antibodies with the extrarenal histopathology of Wegener's (pathergic) granulomatosis and related forms of vasculitis. (PubMed id 8381764)9 Fienberg R....Niles J.L. (1993)
  204. Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells. (PubMed id 1323218)9 Savage C.O....Pearson J.D. (1992)
  205. [Antineutrophil cytoplasmic antibodies] (PubMed id 19370191)9 Sebastiani G.D. (2009)
  206. Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding. (PubMed id 19394830)9 Li Y....Groutas W.C. (2009)
  207. Long-term treatment results and the immunoglobulin G subclass distribution patterns of proteinase-3-antineutrophil cytoplasm antibody (ANCA) and myeloperoxidase-ANCA in ANCA-associated vasculitis. (PubMed id 18979374)9 Almroth G....Hahn-Zoric M. (2009)
  208. Leukocyte proteases cleave von Willebrand factor at o r near the ADAMTS13 cleavage site. (PubMed id 19541819)9 Raife T.J....Zheng X.L. (2009)
  209. CD8+ T-cell responses to tumor-associated antigens co rrelate with superior relapse-free survival after allo-SCT. (PubMed id 19139738)9 Kapp M....Grigoleit G.U. (2009)
  210. Anti-neutrophil cytoplasmic antibody pathogenesis in small-vessel vasculitis: an update. (PubMed id 19815703)9 GA^mez-Puerta J.A. and Bosch X. (2009)
  211. ANCA-Positive Patients: The Influence of PR3 and MPO Antibodies on Survival Rate and The Association with Clinical and Laboratory Characteristics. (PubMed id 19461938)9 Drooger J.C....Swaak A.J. (2009)
  212. Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates. (PubMed id 18536646)9 Korkmaz B....Gauthier F. (2008)
  213. Design of selective substrates of proteinase 3 using combinatorial chemistry methods. (PubMed id 18445466)9 Wysocka M....Rolka K. (2008)
  214. Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions. (PubMed id 18021746)9 Korkmaz B....Gauthier F. (2008)
  215. PR1 vaccination in myeloid malignancies. (PubMed id 18767937)9 Rezvani K. (2008)
  216. Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease. (PubMed id 18211966)9 Cooley J....Remold-O'Donnell E. (2008)
  217. The membrane proteinase 3 expression on neutrophils was downregulated after treatment with infliximab in patients with rheumatoid arthritis. (PubMed id 18372277)9 Matsumoto T....Kurosawa S. (2008)
  218. Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3. (PubMed id 17459006)9 Villegas-Mendez A....Lane D.A. (2007)
  219. Serum concentration of interleukin-18 is up-regulated in patients with ANCA-associated vasculitis. (PubMed id 17966043)9 Hultgren O....Almroth G. (2007)
  220. Anti-myeloperoxidase antibodies enhance phagocytosis, IL-8 production, and glucose uptake of polymorphonuclear neutrophils rather than anti-proteinase 3 antibodies leading to activation-induced cell death of the neutrophils. (PubMed id 16575489)9 Hsieh S.C....Yu C.L. (2007)
  221. Identification of leukocyte cationic proteins that interact with ceruloplasmin. (PubMed id 17922645)9 Sokolov A.V....Vasil'ev V.B. (2007)
  222. Characterization of human pre-elafin mutants: full antipeptidase activity is essential to preserve lung tissue integrity in experimental emphysema. (PubMed id 17489739)9 Doucet A....Bourbonnais Y. (2007)
  223. Contribution of TNF-alpha converting enzyme and proteinase-3 to TNF-alpha processing in human alveolar macrophages. (PubMed id 16210695)9 Armstrong L....Millar A.B. (2006)
  224. Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML. (PubMed id 16144796)9 Yong A.S....Melo J.V. (2006)
  225. Cytokine-dependent proliferation of human CD34+ progenitor cells in the absence of serum is suppressed by their progeny's production of serine proteinases. (PubMed id 16109763)9 Goselink H.M....Falkenburg J.H. (2006)
  226. Priming by tumor necrosis factor-alpha of human neutrophil NADPH-oxidase activity induced by anti-proteinase-3 or anti-myeloperoxidase antibodies. (PubMed id 16997860)9 Reumaux D....Roos D. (2006)
  227. Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides. (PubMed id 17133251)9 Kallenberg C.G....Stegeman C.A. (2006)
  228. Renal expression of ICAM-1 and VCAM-1 in ANCA-associated glomerulonephritis--are there differences among serologic subgroups? (PubMed id 16509455)9 Arrizabalaga P....Ascaso C. (2006)
  229. Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations. (PubMed id 16341903)9 Manolova I. and Dantcheva M. (2005)
  230. Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments. (PubMed id 16182289)9 Wiesner O....Specks U. (2005)
  231. A novel 29-kDa crystal protein from Bacillus thuringi ensis induces caspase activation and cell death of jurkat T cells. (PubMed id 16306686)9 Amano H....Sakai H. (2005)
  232. Circumvention of normal constraints on granule protein gene expression in peripheral blood neutrophils and monocytes of patients with antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. (PubMed id 15284296)9 Yang J.J....Preston G.A. (2004)
  233. The prevalence and target antigens of antithyroid drugs induced antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with hyperthyroidism. (PubMed id 15473130)9 Gao Y....Wang H.Y. (2004)
  234. Linkage of neutrophil serine proteases and decreased surfactant protein-A (SP-A) levels in inflammatory lung disease. (PubMed id 15047952)9 Rubio F....Remold-O'Donnell E. (2004)
  235. [Antibodies to proteinase-3 and myeloperoxidase in systemic vasculitis] (PubMed id 15230127)9 Baranov A.A....AbaA-tova N.E. (2004)
  236. Prevalence of antineutrophil cytoplasmic antibodies in patients with various pulmonary diseases or multiorgan dysfunction. (PubMed id 12687504)9 Vassilopoulos D....Hoffman G.S. (2003)
  237. [Antineutrophil cytoplasmic antibody associated vasculitis induced by antithyroid agents] (PubMed id 12899790)9 Guo X.H....Gao Y. (2003)
  238. Inhibition of proteinase 3 by [alpha]1-antitrypsin in vitro predicts very fast inhibition in vivo. (PubMed id 12600819)9 Duranton J. and Bieth J.G. (2003)
  239. ANCA-positive crescentic glomerulonephritis associated with minocycline therapy. (PubMed id 12900849)9 Sethi S....Oei L.S. (2003)
  240. Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells. (PubMed id 12618518)9 Molldrem J.J....Davis M.M. (2003)
  241. TNF-alpha--accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism. (PubMed id 11849390)9 Kettritz R....Haller H. (2002)
  242. Autoantibodies to proteinase 3 and myeloperoxidase in systemic sclerosis. (PubMed id 12022350)9 Ruffatti A....Todesco S. (2002)
  243. Clinical and pathological manifestations of patients with antineutrophil cytoplasmic autoantibodies directed against proteinase 3 or myeloperoxidase. (PubMed id 12894882)9 Zhang X....Tang F. (2002)
  244. IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytosplasmic antibody-positive patients. (PubMed id 11315931)9 Harper L....Savage C.O. (2001)
  245. Antineutrophil cytoplasmic antibodies reacting with the pro form of proteinase 3 and disease activity in patients with Wegener's granulomatosis and microscopic polyangiitis. (PubMed id 11229478)9 Russell K.A....Specks U. (2001)
  246. Antineutrophil cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: epitope analysis using synthetic peptides. (PubMed id 11135067)9 Van Der Geld Y.M....Kallenberg C.G. (2001)
  247. Epitope mapping on Wegener's granulomatosis autoantig en proteinase 3. (PubMed id 11780345)9 Huang Z. and Lockwood C.M. (2001)
  248. Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site. (PubMed id 11168015)9 Griffith M.E....Pusey C.D. (2001)
  249. Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies. (PubMed id 11134248)9 Kettritz R....Haller H. (2001)
  250. MCF-7 mammary tumour cells express the myeloid cell d ifferentiation controlling factor, serine protease 3/myeloblastin. (PubMed id 11063135)9 Horman S....Galand P. (2000)
  251. Antineutrophil cytoplasmic antibodies and associated diseases: a review of the clinical and laboratory features. (PubMed id 10720938)9 Savige J....Wiik A. (2000)
  252. Induction of neutrophil responsiveness to myeloperoxidase antibodies by their exposure to supernatant of degranulated autologous neutrophils. (PubMed id 11023517)9 Hess C....Schifferli J.A. (2000)
  253. Upregulation of CD14 and CD18 on monocytes In vitro by antineutrophil cytoplasmic autoantibodies. (PubMed id 10966488)9 Nowack R....van der Woude F.J. (2000)
  254. A comparison of commercial and in-house ELISAs for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase. (PubMed id 10212921)9 Pollock W....Savige J. (1999)
  255. Evidence for a crucial role of neutrophil-derived serine proteases in the inactivation of interleukin-6 at sites of inflammation. (PubMed id 10567703)9 Bank U....Ansorge S. (1999)
  256. [Antineutrophil cytoplasmic antibodies in patients with sickle cell anemia] (PubMed id 10618917)9 Villaescusa R....HernA!ndez P. (1999)
  257. Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases. (PubMed id 11370121)9 Wiik A....Heegaard N.H. (1999)
  258. Heat treatment of normal human sera reveals antibodies to bactericidal permeability-inducing protein (BPI). (PubMed id 10403934)9 Brownlee A.A. and Lockwood C.M. (1999)
  259. In vitro neutrophil activation by antibodies to proteinase 3 and myeloperoxidase from patients with crescentic glomerulonephritis. (PubMed id 10405206)9 Franssen C.F....Tervaert J.W. (1999)
  260. [Clinical significance of myeloperoxydase and proteinase 2 antibodies in patients with systemic lupus erythematosus] (PubMed id 10599220)9 Borodin A.G....Bazhina O.V. (1999)
  261. Alpha1-antitrypsin phenotypes and anti-neutrophil cytoplasmic auto-antibodies in inflammatory bowel disease. (PubMed id 10563543)9 Taddei C....Esnault V.L. (1999)
  262. The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G. (PubMed id 10068683)9 Scott F.L....Bird P.I. (1999)
  263. Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation. (PubMed id 10574621)9 Bank U....Ansorge S. (1999)
  264. Peritoneal lavage with aprotinin in patients with severe acute pancreatitis. Effects on plasma and peritoneal levels of trypsin and leukocyte proteases and their major inhibitors. (PubMed id 9746884)9 Berling R....Ohlsson K. (1998)
  265. Antineutrophil cytoplasmic antibodies in Wegener's granulomatosis. (PubMed id 9875021)9 Wong S.N....Dillon M.J. (1998)
  266. Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold. (PubMed id 9681132)9 Groutas W.C....Truong T.M. (1998)
  267. T lymphocyte responses to anti-neutrophil cytoplasmic autoantibody (ANCA) antigens are present in patients with ANCA-associated systemic vasculitis and persist during disease remission. (PubMed id 9649227)9 King W.J....Savage C.O. (1998)
  268. Antineutrophil cytoplasmic antibodies in primary SjAPgren's syndrome: prevalence and clinical significance. (PubMed id 9973150)9 Font J....Ingelmo M. (1998)
  269. Characterisation of anti-neutrophil cytoplasmic antibody target antigens using electrophoresis and western blotting techniques. (PubMed id 10436539)9 Forde A.M....Jackson J. (1998)
  270. Anti-neutrophil cytoplasmic antibodies in 566 European patients with systemic lupus erythematosus: prevalence, clinical associations and correlation with other autoantibodies. European Concerted Action on the Immunogenetics of SLE. (PubMed id 9779300)9 Galeazzi M....Smolen J. (1998)
  271. Inhibition of neutrophil serine proteinases by suramin. (PubMed id 9092534)9 CadA"ne M....Bieth J.G. (1997)
  272. Rapid screening assay for anti-GBM antibody and ANCAs; an important tool for the differential diagnosis of pulmonary renal syndromes. (PubMed id 9306336)9 Westman K.W....Wieslander J. (1997)
  273. Comparative evaluation of unfixed and fixed human neutrophils for determination of antineutrophil cytoplasmic antibodies by indirect immunofluorescence. (PubMed id 9301553)9 Yang P. (1997)
  274. Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G, and proteinase 3: evidence for distinct cleavage sites within the aminoterminal domain of the thrombin receptor. (PubMed id 9058715)9 Renesto P....Chignard M. (1997)
  275. Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3. (PubMed id 8806743)9 Groutas W.C....Hoidal J.R. (1996)
  276. Development and standardization of solid phase assays for the detection of anti-neutrophil cytoplasmic antibodies (ANCA). A report on the second phase of an international cooperative study on the standardization of ANCA assays. (PubMed id 8841439)9 Hagen E.C....Van der Woude F.J. (1996)
  277. The syndrome of lung hemorrhage and nephritis is usually an ANCA-associated condition. (PubMed id 8607730)9 Niles J.L....McCluskey R.T. (1996)
  278. Antineutrophil cytoplasmic antibodies in synovial fluid and in serum of patients with rheumatoid arthritis and other types of synovitis. (PubMed id 8838502)9 Afeltra A....Bonomo L. (1996)
  279. Complexes between proteinase 3, alpha 1-antitrypsin and proteinase 3 anti-neutrophil cytoplasm autoantibodies: a comparison between alpha 1-antitrypsin PiZ allele carriers and non-carriers with Wegener's granulomatosis. (PubMed id 8889441)9 Baslund B....Petersen J. (1996)
  280. C-antineutrophil cytoplasmic antibody positivity in vasculitis patients is associated with the Z allele of alpha-1-antitrypsin, and P-antineutrophil cytoplasmic antibody positivity with the S allele. (PubMed id 8671812)9 Griffith M.E....Pusey C.D. (1996)
  281. Epitope mapping of anti-proteinase 3 and anti-myeloperoxidase antibodies. (PubMed id 7554377)9 Chang L....Savige J. (1995)
  282. Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis. (PubMed id 7813109)9 Zhao M.H....Lockwood C.M. (1995)
  283. Anti-neutrophil cytoplasmic antibody for proteinase 3 in a child with polyarteritis nodosa. (PubMed id 7754755)9 Ito Y....Kato H. (1995)
  284. Vasculitis. (PubMed id 8557852)9 Smith J.G. (1995)
  285. Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3. (PubMed id 8581420)9 Groutas W.C....Hoidal J.R. (1995)
  286. The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3. (PubMed id 7796053)9 Groutas W.C....Hoidal J.R. (1995)
  287. Antineutrophil cytoplasmic autoantibodies, autoantigens, and systemic vasculitis. (PubMed id 7748541)9 Gross W.L....Helmchen U. (1995)
  288. Effect of proctocolectomy on serum antineutrophil cytoplasmic antibodies in patients with chronic ulcerative colitis. (PubMed id 7560172)9 Aitola P....Soppi E. (1995)
  289. A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. (PubMed id 7836914)9 Kain R....Kerjaschki D. (1995)
  290. The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. (PubMed id 7713495)9 Pilat D.... Jenne D.E. (1994)
  291. Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo. (PubMed id 8306499)9 Csernok E....Gross W.L. (1994)
  292. [Detection of anti-neutrophil cytoplasmic antibodies with proteinase 3 specificity by immunoblotting] (PubMed id 7854857)9 Chevailler A....Hurez D. (1994)
  293. Myeloblastin/proteinase 3 belongs to the set of negatively regulated primary response genes expressed during in vitro myeloid differentiation. (PubMed id 8179593)9 Chen T....Tobler A. (1994)
  294. Antineutrophil cytoplasmic antibodies in Wegener's granulomatosis and other diseases: clinical issues. (PubMed id 7828332)9 Galperin C. and Hoffman G.S. (1994)
  295. Lesions of the respiratory tract associated with the finding of anti-neutrophil cytoplasmic autoantibodies with a perinuclear staining pattern. (PubMed id 8065182)9 DeRemee R.A....Specks U. (1994)
  296. Structural and functional characterization of elastases from horse neutrophils. (PubMed id 7516152)9 Dubin A....Travis J. (1994)
  297. Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa. (PubMed id 8027554)9 Porges A.J....Kimberly R.P. (1994)
  298. [Antineutrophil cytoplasmic antibodies as marker and follow-up parameter of vasculitis and glomerulonephritis] (PubMed id 7973270)9 WA1thrich R.P. (1994)
  299. The heterogeneity of azurophil granules in neutrophil promyelocytes: immunogold localization of myeloperoxidase, cathepsin G, elastase, proteinase 3, and bactericidal/permeability increasing protein. (PubMed id 8180395)9 Egesten A....Olsson I. (1994)
  300. Anti-nuclear, anti-neutrophil cytoplasmic and anti-glomerular basement membrane antibodies in HIV-infected individuals. (PubMed id 7858105)9 Savige J.A....Crowe S.M. (1994)
  301. ANCA in haemodialysis patients. (PubMed id 8255517)9 Weidemann S....Ritz E. (1993)
  302. Anti-neutrophil cytoplasm antibodies can recognize vascular endothelial cell-bound anti-neutrophil cytoplasm antibody-associated autoantigens. (PubMed id 7915959)9 Savage C.O....Pearson J.D. (1993)
  303. Proteinase 3: substrate specificity and possible pathogenetic effect of Wegener's granulomatosis autoantibodies (c-ANCA) by dysregulation of the enzyme. (PubMed id 8296674)9 Dolman K.M....Goldschmeding R. (1993)
  304. Alpha 1-antitrypsin genetic polymorphism in ANCA-positive systemic vasculitis. (PubMed id 8315946)9 Esnault V.L....Lesavre P. (1993)
  305. Clinical significance of ANCA in 98 patients. (PubMed id 7905232)9 Geffriaud-Ricouard C....Lesavre P. (1993)
  306. Significance of autoantibodies to purified proteinase 3 in systemic vasculitis. (PubMed id 8296619)9 Gaskin G....Pusey C.D. (1993)
  307. p-ANCA with myeloperoxidase antibodies and c-ANCA with proteinase 3 antibodies define a different vasculitis entity in patients with renal involvement. (PubMed id 8296653)9 Dringenberg C....Andrassy K. (1993)
  308. Antineutrophil cytoplasmic autoantibodies in inflammatory bowel diseases. (PubMed id 1426820)9 Colombel J.F....Cortot A. (1992)
  309. Antigen-specific radioimmunoassays for anti-neutrophil cytoplasmic antibodies in the diagnosis of rapidly progressive glomerulonephritis. (PubMed id 1655091)9 Niles J.L....McCluskey R.T. (1991)
  310. Antineutrophil cytoplasmic autoantibodies antigen specificity. (PubMed id 1714231)9 Lesavre P. (1991)
  311. Antigen specificities and clinical distribution of ANCA in kidney diseases. (PubMed id 1721665)9 Lesavre P....GrA1nfeld J.P. (1991)
  312. Elafin is a potent inhibitor of proteinase 3. (PubMed id 1989620)9 Wiedow O....Utecht B. (1991)
  313. How are antineutrophil cytoplasmic autoantibodies detected? (PubMed id 1867172)9 Wieslander J. (1991)
  314. Analysis of T-cell receptor usage in myeloperoxidase- -antineutrophil cytoplasmic antibody-associated renal vasculitis. (PubMed id 19809783)9 Hirayama K....Koyama A. (2010)
  315. Pathogenesis of small vessel vasculitis associated wi th autoantibodies to neutrophil cytoplasmic antigens: new insights from animal models. (PubMed id 19823088)9 Kain R....Rees A.J. (2010)
  316. Is presence of ANCA in crescentic IgA nephropathy a c oincidence or novel clinical entity? A case series. (PubMed id 20042261)9 Bantis C....Heering P.J. (2010)
  317. Tumour antigen-targeted immunotherapy for chronic mye loid leukaemia: is it still viable? (PubMed id 19259670)9 Riley C.L....Rees R.C. (2009)
  318. EUROPLUS ANCA BIOCHIP mosaic: PR3 and MPO antigen mic rodots improve the laboratory diagnostics of ANCA-associated vasculitis. (PubMed id 19615371)9 Damoiseaux J....Tervaert J.W. (2009)
  319. High-sensitivity detection of autoantibodies against proteinase-3 by a novel third-generation enzyme-linked immunosorbent assay. (PubMed id 19758130)9 Roggenbuck D....Conrad K. (2009)
  320. Anti-proteinase 3 antibodies both stimulate and prime human neutrophils. (PubMed id 18952697)9 Uriarte S.M....Ward R.A. (2009)
  321. Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3. (PubMed id 19446593)9 Piesche M....Schroers R. (2009)
  322. LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypert onic saline. (PubMed id 19542465)9 Bergsson G....McElvaney N.G. (2009)
  323. Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3. (PubMed id 19292764)9 Armstrong L....Millar A.B. (2009)
  324. Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: Anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils. (PubMed id 19404956)9 Hu N....Kallenberg C.G. (2009)
  325. Urinary CD4+ effector memory T cells reflect renal di sease activity in antineutrophil cytoplasmic antibody-associated vasculitis. (PubMed id 19714581)9 Abdulahad W.H....Stegeman C.A. (2009)
  326. Review article: The role of CD4(+) T cells in ANCA-associated systemic vasculitis. (PubMed id 19143940)9 Abdulahad W.H....Kallenberg C.G. (2009)
  327. Challenges in pKa predictions for proteins: the case of Asp213 in human proteinase 3. (PubMed id 19780520)9 Hajjar E....Reuter N. (2009)
  328. Peptide vaccines for patients with acute myeloid leuk emia. (PubMed id 19803762)9 Schmitt M....Schmitt A. (2009)
  329. What do biomarkers tell us about the pathogenesis of ankylosing spondylitis? (PubMed id 19183433)9 Maksymowych W.P. (2009)
  330. [Antineutrophil cytoplasmic antibodies and associated diseases] (PubMed id 18834675)9 Sghiri R....Ghedira I. (2009)
  331. Protease inhibitors derived from elafin and SLPI and engineered to have enhanced specificity towards neutrophil serine proteases. (PubMed id 19241385)9 Zani M.L....Moreau T. (2009)
  332. Evaluation of the combined application of ethanol-fixed and formaldehyde-fixed neutrophil substrates for identifying atypical perinuclear antineutrophil cytoplasmic antibodies in inflammatory bowel disease. (PubMed id 19193830)9 Papp M....Lakatos P.L. (2009)
  333. Neutrophil-derived serine proteases modulate innate immune responses. (PubMed id 19273284)9 Meyer-Hoffert U. (2009)
  334. [Immunotherapy and cell therapy for myeloid leukemia] (PubMed id 19860194)9 Yasukawa M. (2009)
  335. Antineutrophil cytoplasmic antibody-associated vascul itides and respiratory disease. (PubMed id 19809051)9 GA^mez-Puerta J.A....Bosch X. (2009)
  336. Identification of human cathepsin G as a functional t arget of boswellic acids from the anti-inflammatory remedy frankincense. (PubMed id 19648270)9 Tausch L....Werz O. (2009)
  337. [Primary cutaneous manifestation of Wegener's granulomatosis] (PubMed id 18592451)9 Bramsiepe I....Fiedler E. (2008)
  338. Scleroderma with crescentic glomerulonephritis: a case report. (PubMed id 18474117)9 Ramaswami A....Kafeel G. (2008)
  339. Antibodies with dual reactivity to plasminogen and complementary PR3 in PR3-ANCA vasculitis. (PubMed id 18701607)9 Bautz D.J....Falk R.J. (2008)
  340. Single cell analysis of B lymphocytes from Wegener's granulomatosis: B cell receptors display affinity maturation within the granulomatous lesions. (PubMed id 18826496)9 Voswinkel J....Mueller A. (2008)
  341. Wegener's granulomatosis presenting as pyoderma gangrenosum. (PubMed id 18076660)9 Boudny C....Simon D. (2008)
  342. Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family. (PubMed id 17964057)9 Moreau T....Zani M.L. (2008)
  343. A little help from our friends: what an epidemiologic study teaches us about autoinflammation, granuloma and proteinase-3-specific antineutrophil cytoplasmic autoantibodies. (PubMed id 18852187)9 Lamprecht P. and Gross W.L. (2008)
  344. Cleaved SLPI, a novel biomarker of chymase activity. (PubMed id 18713008)9 Belkowski S.M....D'Andrea M.R. (2008)
  345. Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma. (PubMed id 18181035)9 Csernok E....Gross W.L. (2008)
  346. Levels of autoantibodies, unlike antibodies to all ex trinsic antigen groups, fall following B cell depletion with Rituximab. (PubMed id 18085668)9 Ferraro A.J....MacLennan I.C. (2008)
  347. Antibodies to proteinase 3 prime human oral, lung, and kidney epithelial cells to secrete proinflammatory cytokines upon stimulation with agonists to various Toll-like receptors, NOD1, and NOD2. (PubMed id 18495849)9 Uehara A....Takada H. (2008)
  348. Protein microarrays with carbon nanotubes as multicolor Raman labels. (PubMed id 18953353)9 Chen Z....Dai H. (2008)
  349. [Severe chronic headache with depression induced by pachymeningitis in Wegener's granulomatosis] (PubMed id 18213550)9 von Bierbrauer A....Fischer V. (2008)
  350. In vitro activation of the rhesus macaque myeloid alpha-defensin precursor proRMAD-4 by neutrophil serine proteinases. (PubMed id 18775986)9 Kamdar K....Ouellette A.J. (2008)
  351. Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils. (PubMed id 18178964)9 Mydel P....Senior R.M. (2008)
  352. Hematopoietic stem cells and progenitors of chronic myeloid leukemia express leukemia-associated antigens: implications for the graft-versus-leukemia effect and peptide vaccine-based immunotherapy. (PubMed id 18548092)9 Yong A.S....Barrett A.J. (2008)
  353. Antigen-specific ANCA ELISAs have different sensitivities for active and treated vasculitis and for nonvasculitic disease. (PubMed id 18089488)9 Trevisin M....Savige J. (2008)
  354. Role of neutrophil proteinase 3 and mast cell chymase in chemerin proteolytic regulation. (PubMed id 18753310)9 Guillabert A....Communi D. (2008)
  355. Proteinase 3-processed form of the recombinant IL-32 separate domain. (PubMed id 19017495)9 Kim S....Kim S. (2008)
  356. Crosstalk between inflammation and thrombosis. (PubMed id 19437587)9 Esmon C.T. (2008)
  357. Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission. (PubMed id 18576340)9 Abdulahad W.H....Kallenberg C.G. (2008)
  358. Mass spectroscopic characteristics of low molecular weight proteins extracted from calcium oxalate stones: preliminary study. (PubMed id 18200570)9 Chen W.C....Tsai F.J. (2008)
  359. [New aspects of the pathogenesis of gout. Danger signals, autoinflammation and beyond] (PubMed id 18299853)9 Lamprecht P....Kabelitz D. (2008)
  360. Leukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells. (PubMed id 19010831)9 Greiner J....Schmitt M. (2008)
  361. Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides. (PubMed id 17976994)9 Li Y....Groutas W.C. (2008)
  362. Proteinase 3, protease-activated receptor-2 and interleukin-32: linking innate and autoimmunity in Wegener's granulomatosis. (PubMed id 18799068)9 Csernok E....Gross W.L. (2008)
  363. Valvular injury in a patient with PR3-ANCA-associated glomerulonephritis. (PubMed id 18762796)9 Iwatani H....Imai E. (2008)
  364. Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia. (PubMed id 18565849)9 Mohty M....Melo J.V. (2008)
  365. The target antigens of antineutrophil cytoplasmic antibodies (ANCA) induced by propylthiouracil. (PubMed id 17161817)9 Gao Y....Wang H.Y. (2007)
  366. Translational mini-review series on vaccines: Peptide vaccines for myeloid leukaemias. (PubMed id 17437417)9 Barrett A.J. and Rezvani K. (2007)
  367. Febrile temperatures control antineutrophil cytoplasmic autoantibody-induced neutrophil activation via inhibition of phosphatidylinositol 3-kinase/Akt. (PubMed id 17763432)9 von Vietinghoff S....Kettritz R. (2007)
  368. Neutrophil-specific antigen HNA-2a, NB1 glycoprotein, and CD177. (PubMed id 17898576)9 Stroncek D.F. (2007)
  369. Standardised assessment of membrane proteinase 3 expression. Analysis in ANCA-associated vasculitis and controls. (PubMed id 17446240)9 van Rossum A.P....Kallenberg C.G. (2007)
  370. The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G. (PubMed id 17384412)9 Campbell E.J. and Owen C.A. (2007)
  371. [Wegener's granulomatosis in 2 adolescents] (PubMed id 17763812)9 van der Aa L.B....van den Berg J.M. (2007)
  372. Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis. (PubMed id 17521322)9 Rajp A....Savage C.O. (2007)
  373. [A case of MA1nchausen syndrome with recurrent bacteremia and PR3-ANCA positivity] (PubMed id 17447478)9 Hashimoto A....Endo H. (2007)
  374. Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients. (PubMed id 17030385)9 Komine K....Sugawara S. (2007)
  375. Analysis of individual azurocidin N-glycosylation sites in regard to its secretion by insect cells, susceptibility to proteolysis and antibacterial activity. (PubMed id 17653303)9 Indyk K....Olczak M. (2007)
  376. Current knowledge on cellular interactions in the WG-granuloma. (PubMed id 17428367)9 Lamprecht P. and Gross W.L. (2007)
  377. Clinical and pathological features of renal involvement in propylthiouracil-associated ANCA-positive vasculitis. (PubMed id 17472842)9 Yu F....Wang H.Y. (2007)
  378. Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA). (PubMed id 17614969)9 Talor M.V....Burek C.L. (2007)
  379. Chimeric antibodies to proteinase 3 of IgG1 and IgG3 subclasses induce different magnitudes of functional responses in neutrophils. (PubMed id 17204568)9 Colman R....Williams J.M. (2007)
  380. Immunotherapeutic strategies in chronic myeloid leuke mia. (PubMed id 20425356)9 Clark R.E. (2007)
  381. [B lymphocyte differentiation in granulomatous tissues of the lung and the nasal mucosa in Wegener's granulomatosis: origin of anti-neutrophil cytoplasmic antibody formation?] (PubMed id 17516076)9 Kramer J.A....Voswinkel J. (2007)
  382. [New insights into the pathogenesis of ANCA-positive vasculitides] (PubMed id 17350787)9 Guilpain P....Mouthon L. (2007)
  383. ANCA-associated vasculitis: diagnostic and therapeutic strategy. (PubMed id 17460438)9 Ozaki S. (2007)
  384. [Classification of systemic vasculatides] (PubMed id 17408915)9 Guillevin L....Guilpain P. (2007)
  385. Severe dysphagia in lower cranial nerve involvement as the initial symptom of Wegener's granulomatosis. (PubMed id 17658554)9 Armani M....Tavolato B. (2007)
  386. Review Paper: Dental treatment for patients with Papi llon-LefA"vre syndrome (PLS). (PubMed id 17303050)9 Ullbro C. and Twetman S. (2007)
  387. Latex immunoagglutination assay for a vasculitis marker in a microfluidic device using static light scattering detection. (PubMed id 17141495)9 Lucas L.J....Yoon J.Y. (2007)
  388. Human leukocyte elastase hydrolysis of peptides derived from human elastin exon 24. (PubMed id 16945464)9 Lombard C....Saulnier J. (2006)
  389. Role of polymorphonuclear leukocyte-derived serine proteinases in defense against Actinobacillus actinomycetemcomitans. (PubMed id 16926422)9 de Haar S.F....Beertsen W. (2006)
  390. Wegener's granulomatosis of the penis: genital presentation of systemic disease. (PubMed id 16707888)9 Al Rajabi W....Calzavara-Pinton P. (2006)
  391. Alpha-melanocyte-stimulating hormone down-regulates CXC receptors through activation of neutrophil elastase. (PubMed id 16479540)9 Manna S.K....Sreenivasan Y. (2006)
  392. Identification of novel functional sequence variants in the gene for peptidase inhibitor 3. (PubMed id 16719916)9 Chowdhury M.A....Tromp G. (2006)
  393. [A case of squamous cell carcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody] (PubMed id 17228809)9 Morisako T....Matsuoka T. (2006)
  394. Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer. (PubMed id 17143367)9 Al-Shukaili A....Al-Moundhri M.S. (2006)
  395. Targeting serine proteases in asthma. (PubMed id 16611150)9 Guay C....Tremblay G.M. (2006)
  396. Neutrophil granule proteins as targets of leukemia-specific immune responses. (PubMed id 16319682)9 Barrett J. and Rezvani K. (2006)
  397. Production and applications of recombinant proteinase 3, Wegener's autoantigen: problems and perspectives. (PubMed id 16995336)9 Jenne D.E. and Kuhl A. (2006)
  398. TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations. (PubMed id 17699331)9 Huugen D....Heeringa P. (2006)
  399. Human antimicrobial peptide LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study. (PubMed id 17181861)9 Ciornei C.D....Bodelsson M. (2006)
  400. Cancer vaccines for patients with acute myeloid leukemia--definition of leukemia-associated antigens and current clinical protocols targeting these antigens. (PubMed id 17145602)9 Greiner J....Schmitt M. (2006)
  401. A novel MHC-associated proteinase 3 peptide isolated from primary chronic myeloid leukaemia cells further supports the significance of this antigen for the immunotherapy of myeloid leukaemias. (PubMed id 16628186)9 Knights A.J....Pawelec G. (2006)
  402. Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall. (PubMed id 15485998)9 Hermann J....Graninger W. (2005)
  403. A novel capture-ELISA for detection of anti-neutrophil cytoplasmic antibodies (ANCA) based on c-myc peptide recognition in carboxy-terminally tagged recombinant neutrophil serine proteases. (PubMed id 16242707)9 Lee A.S....Specks U. (2005)
  404. The influence of different cultivating conditions on polymorphonuclear leukocyte apoptotic process in vitro, II: ultrastructural characteristics of PMN populations incubated with proteinase 3 anti-neutrophil autoantibodies. (PubMed id 15931779)9 Guejes L....Shoenfeld Y. (2005)
  405. Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase. (PubMed id 15653931)9 Oltmanns U....Chung K.F. (2005)
  406. Neutrophil serine proteases: potential key regulators of cell signalling during inflammation. (PubMed id 15788001)9 Wiedow O. and Meyer-Hoffert U. (2005)
  407. Glycosaminoglycan: a candidate to stimulate the repair of chronic wounds. (PubMed id 16113778)9 Peplow P.V. (2005)
  408. In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins. (PubMed id 15958635)9 Fujiwara H....Barrett A.J. (2005)
  409. New insights that link microbes with the generation of antineutrophil cytoplasmic autoantibodies: the theory of autoantigen complementarity. (PubMed id 15821413)9 Preston G.A....Falk R.J. (2005)
  410. Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase. (PubMed id 16300411)9 Guyot N....Moreau T. (2005)
  411. Dendritic cells generated from acute myeloid leukemia (AML) blasts maintain the expression of immunogenic leukemia associated antigens. (PubMed id 15627212)9 Li L....Schmitt M. (2005)
  412. Antigen-specific cellular immunotherapy of leukemia. (PubMed id 16121214)9 Van Driessche A....Van Tendeloo V.F. (2005)
  413. Neutrophil activation in anti-proteinase 3-positive vasculitis--a prospective study. (PubMed id 16316421)9 Wikman A....Jacobson S.H. (2005)
  414. Activation, apoptosis, and clearance of neutrophils in Wegener's granulomatosis. (PubMed id 16126939)9 van Rossum A.P....Kallenberg C.G. (2005)
  415. Analysis of a biomarker for Wegener's granulomatosis. (PubMed id 16026591)9 Cooley P....Taylor J.F. (2005)
  416. Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation. (PubMed id 16006536)9 Hattar K....Sibelius U. (2005)
  417. Off balance: T-cells in antineutrophil cytoplasmic an tibody (ANCA)-associated vasculitides. (PubMed id 15996183)9 Lamprecht P. (2005)
  418. Proteinase 3 hydrolysis of peptides derived from human elastin exon 24. (PubMed id 15895295)9 Lombard C....Saulnier J. (2005)
  419. Autoantibody formation in patients with rheumatoid arthritis treated with anti-TNF alpha. (PubMed id 15297281)9 Eriksson C....RantapAoAo-Dahlqvist S. (2005)
  420. Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases. (PubMed id 15728180)9 Ryu O.H....Hart T.C. (2005)
  421. Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain. (PubMed id 15078883)9 Hirche T.O....Belaaouaj A. (2004)
  422. Immune complex deposits in ANCA-associated crescentic glomerulonephritis: a study of 126 cases. (PubMed id 15149327)9 Haas M. and Eustace J.A. (2004)
  423. Proteolytic conversion of STAT3alpha to STAT3gamma in human neutrophils: role of granule-derived serine proteases. (PubMed id 15145953)9 Kato T....Kitagawa S. (2004)
  424. Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study. (PubMed id 14585921)9 Csernok E....Gross W.L. (2004)
  425. Antineutrophil cytoplasmic antibodies (ANCA): diagnostic utility and potential role in the pathogenesis of vasculitis. (PubMed id 15588565)9 Malenica B....Kozmar A. (2004)
  426. Genetic impact of pathogenesis and prognosis of ANCA-associated vasculitides. (PubMed id 15675141)9 Borgmann S. and Haubitz M. (2004)
  427. Clonogenicity, gene expression and phenotype during neutrophil versus erythroid differentiation of cytokine-stimulated CD34+ human marrow cells in vitro. (PubMed id 15521924)9 Edvardsson L....Olofsson T. (2004)
  428. Shunt nephritis with positive titers for ANCA specific for proteinase 3. (PubMed id 15112193)9 Iwata Y....Yoshida K. (2004)
  429. Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase. (PubMed id 15070688)9 Fujiwara H....Barrett A.J. (2004)
  430. [Clinical characteristics of propylthiouracil (PTU) induced antineutrophil cytoplasmic antibodies positive cases; analysis of a case of PTU-induced ANCA positive patients with hyperthyroidism] (PubMed id 15730621)9 Li M.T....Tang F.L. (2004)
  431. Aneurysmal subarachnoid hemorrhage in a patient with Wegener's granulomatosis. (PubMed id 15480908)9 Takei H....Katayama Y. (2004)
  432. Monocyte activation by circulating fibronectin fragments in HIV-1-infected patients. (PubMed id 15265957)9 Trial J....Rossen R.D. (2004)
  433. Loss-of-function mutations in cathepsin C in two families with Papillon-Lefevre syndrome are associated with deficiency of serine proteinases in PMNs. (PubMed id 15108292)9 de Haar S.F....Beertsen W. (2004)
  434. Selective killing of B-cell hybridomas targeting prot einase 3, Wegener's autoantigen. (PubMed id 15147566)9 Reiners K.S....Von Strandmann E.P. (2004)
  435. Epitope mapping of anti-PR3 antibodies using chimeric human/mouse PR3 recombinant proteins. (PubMed id 14678279)9 Selga D....Hellmark T. (2004)
  436. Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo. (PubMed id 15150076)9 Pfister H....Jenne D.E. (2004)
  437. Monoclonal LYM-1 antibody-dependent cytolysis by human neutrophils exposed to GM-CSF: auto-regulation of target cell attack by cathepsin G. (PubMed id 14525961)9 Ottonello L....Dallegri F. (2004)
  438. Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre-elafin (trappin-2) expressed in Pichia pastoris. (PubMed id 15182352)9 Zani M.L....Moreau T. (2004)
  439. Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report. (PubMed id 15459817)9 Kanazawa M....Gejyo F. (2004)
  440. Crosstalk between inflammation and thrombosis. (PubMed id 15063484)9 Esmon C.T. (2004)
  441. Positive classic antineutrophil cytoplasmic antibody (C-ANCA) titer at switch to azathioprine therapy associated with relapse in proteinase 3-related vasculitis. (PubMed id 15077271)9 Slot M.C....Stegeman C.A. (2004)
  442. Use of immunofluorescence and confocal laser scanning microscopy in identifying rare cases of anti-neutrophil cytoplasmic antibodies (ANCA) showing dual specificities to myeloperoxidase and proteinase3. (PubMed id 15617388)9 Badakere S.S....Pawar A.R. (2004)
  443. Rapid inactivation of alpha-1-proteinase inhibitor by neutrophil specific leukolysin/membrane-type matrix metalloproteinase 6. (PubMed id 15149845)9 Nie J. and Pei D. (2004)
  444. B cell epitope specificity in ANCA-associated vasculitis: does it matter? (PubMed id 15320893)9 van der Geld Y.M....Kallenberg C.G. (2004)
  445. Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina. (PubMed id 12759353)9 Sorensen O.E....Borregaard N. (2003)
  446. Diversity of PR3-ANCA epitope specificity in Wegener's granulomatosis. Analysis using the biosensor technology. (PubMed id 15031633)9 Rarok A.A....Kallenberg C.G. (2003)
  447. Plasma neutrophil lipocalin, elastase-alpha1-antitrypsin complex and neutrophil protease 4 in preterm infants with respiratory distress syndrome. (PubMed id 12751689)9 Sveger T....Laurin S. (2003)
  448. Antineutrophil cytoplasmic antibodies (ANCA) and small vessel vasculitis. (PubMed id 12945480)9 Mareen P....Dierick J. (2003)
  449. Audit of the clinical usefulness of a rapid qualitative ELISA screen for antimyeloperoxidase and antiproteinase 3 antibodies in the assessment of patients with suspected vasculitis. (PubMed id 14514783)9 Aslam A....Misbah S.A. (2003)
  450. Frequency of antineutrophil cytoplasmic antibody in Graves' disease patients treated with methimazole. (PubMed id 12727967)9 GumA M....OlivAc A. (2003)
  451. Sinonasal osteocartilaginous necrosis in cocaine abus ers: experience in 25 patients. (PubMed id 12693654)9 Trimarchi M....Specks U. (2003)
  452. Monitoring proteinase 3 antineutrophil cytoplasmic antibodies for detection of relapses in small vessel vasculitis. (PubMed id 12965902)9 Segelmark M....Jennette J.C. (2003)
  453. [Prevalence and specificity of antineutrophil cytoplasmic antibodies (ANCA) in connective tissue diseases] (PubMed id 12879764)9 Puszczewicz M....Tuchocka A. (2003)
  454. Bactericidal/permeability-increasing protein and cathepsin G are the major antigenic targets of antineutrophil cytoplasmic autoantibodies in systemic sclerosis. (PubMed id 12784398)9 Khanna D....Misra R. (2003)
  455. Expression of myeloperoxidase (MPO) by neutrophils is necessary for their activation by anti-neutrophil cytoplasm autoantibodies (ANCA) against MPO. (PubMed id 12773517)9 Reumaux D....Roos D. (2003)
  456. Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2. (PubMed id 12759451)9 Uehara A....Sugawara S. (2003)
  457. Neutrophil-activating potential of antineutrophil cyt oplasm autoantibodies. (PubMed id 12832437)9 Rarok A.A....Kallenberg C.G. (2003)
  458. Membrane proteinase 3 expression on resting neutrophils as a pathogenic factor in PR3-ANCA-associated vasculitis. (PubMed id 14740429)9 van Rossum A.P....Kallenberg C.G. (2003)
  459. Coagulation and inflammation. (PubMed id 12831462)9 Esmon C.T. (2003)
  460. Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis. (PubMed id 12393522)9 El Ouriaghli F....Barrett A.J. (2003)
  461. Natural T cell immunity against cancer. (PubMed id 14555498)9 Nagorsen D....Keilholz U. (2003)
  462. Pulmonary-renal vasculitic disorders: differential diagnosis and management. (PubMed id 12628041)9 Jara L.J....Calleja M.C. (2003)
  463. Effects of carboxy-terminal modifications of proteinase 3 (PR3) on the recognition by PR3-ANCA. (PubMed id 12631144)9 Capizzi S.A....Specks U. (2003)
  464. Does infection play a role in the pathogenesis of pulmonary vasculitis? (PubMed id 12652450)9 Capizzi S.A. and Specks U. (2003)
  465. Increased expression of the secretory leukocyte proteinase inhibitor in Wegener's granulomatosis. (PubMed id 12519404)9 Ohlsson S....Wieslander J. (2003)
  466. Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells. (PubMed id 12591275)9 Levesque J.P....Simmons P.J. (2003)
  467. Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses. (PubMed id 12763937)9 Amrolia P.J....Brenner M.K. (2003)
  468. Proteolysis of surfactant protein D by cystic fibrosis relevant proteases. (PubMed id 12953146)9 von Bredow C....Griese M. (2003)
  469. Borrelia burgdorferi are susceptible to killing by a variety of human polymorphonuclear leukocyte components. (PubMed id 11920297)9 Lusitani D....Montgomery R.R. (2002)
  470. Interaction of antibodies to proteinase 3 (classic anti-neutrophil cytoplasmic antibody) with human renal tubular epithelial cells: impact on signaling events and inflammatory mediator generation. (PubMed id 11884479)9 Hattar K....Sibelius U. (2002)
  471. [ANCA-associated vasculitis] (PubMed id 12195410)9 Sinico R.A....Radice A. (2002)
  472. Novel genetic association of Wegener's granulomatosis with the interleukin 10 gene. (PubMed id 11838849)9 Zhou Y....Lefvert A.K. (2002)
  473. Kinetics of thrombomodulin release and endothelial cell injury by neutrophil-derived proteases and oxygen radicals. (PubMed id 12423310)9 Boehme M.W....Stremmel W. (2002)
  474. ANCA-positive glomerulonephritis and IgA nephropathy in a patient on propylthiouracil. (PubMed id 11956877)9 Winters M.J....Lirenman D.S. (2002)
  475. Measurement of free and membrane-bound cathepsin G in human neutrophils using new sensitive fluorogenic substrates. (PubMed id 12088507)9 Attucci S....Gauthier F. (2002)
  476. Release and degradation of angiotensin I and angiotensin II from angiotensinogen by neutrophil serine proteinases. (PubMed id 11747312)9 Ramaha A. and Patston P.A. (2002)
  477. Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major autoantigens in hepatitis C virus (HCV) infection. (PubMed id 11985526)9 Wu Y.Y....Tsay G.J. (2002)
  478. Anti-neutrophil cytoplasmic antibody (ANCA) levels directed against proteinase-3 and myeloperoxidase are helpful in predicting disease relapse in ANCA-associated small-vessel vasculitis. (PubMed id 12454214)9 Stegeman C.A. (2002)
  479. Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. (PubMed id 11784720)9 Patzke H. and Tsai L.H. (2002)
  480. -463 G/A myeloperoxidase promoter polymorphism is associated with clinical manifestations and the course of disease in MPO-ANCA-associated vasculitis. (PubMed id 12027420)9 Reynolds W.F....Tervaert J.W. (2002)
  481. Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production. (PubMed id 12223522)9 Nemoto E....Shimauchi H. (2002)
  482. Are autoantibodies present in patients with subacute and chronic urticaria? (PubMed id 11436965)9 Ryhal B....Gershwin M.E. (2001)
  483. Antineutrophil cytoplasmic autoantibody specific for proteinase 3 in a patient with shunt nephritis induced by Gemella morbillorum. (PubMed id 11325703)9 Nagashima T....Minota S. (2001)
  484. Anti-MPO-ANCA-positive microscopic polyangiitis following subacute bacterial endocarditis. (PubMed id 11771532)9 Hellmich B....Schatz H. (2001)
  485. More than destructive: neutrophil-derived serine proteases in cytokine bioactivity control. (PubMed id 11272269)9 Bank U. and Ansorge S. (2001)
  486. Comparison of anti-PR3 capture and anti-PR3 direct EL ISA for detection of antineutrophil cytoplasmic antibodies (ANCA) in long-term clinical follow-up of PR3-ANCA-associated vasculitis patients. (PubMed id 11680659)9 Arranz O....Darnell A. (2001)
  487. Glomerular lesions in patients with Churg-Strauss syndrome and the anti-myeloperoxidase antibody. (PubMed id 11434353)9 Kikuchi Y....Miura S. (2001)
  488. 1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases. (PubMed id 11361013)9 Groutas W.C....Vu N.T. (2001)
  489. Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation. (PubMed id 11445734)9 Esmon C.T. (2001)
  490. Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin. (PubMed id 11415941)9 Rooney C.P....O'Neill S.J. (2001)
  491. Antineutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus: prevalence, antigen specificity, and clinical associations. (PubMed id 11518040)9 Manolova I....Halacheva K. (2001)
  492. Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis. (PubMed id 11200073)9 Hattar K....Grimminger F. (2001)
  493. Inhibition of serine proteases by functionalized sulf onamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold. (PubMed id 11408173)9 Groutas W.C....Chan H.K. (2001)
  494. Analysis of anti-neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects. (PubMed id 11208991)9 Audrain M.A....Esnault V.L. (2001)
  495. What you should know about PR3-ANCA. Structural aspects of antibodies to proteinase 3 (PR3). (PubMed id 11094437)9 Peen E. and Williams R.C. (2000)
  496. Indirect immunofluorescence (IIF) of normal washed peripheral blood cells to demonstrate antineutrophil cytoplasmic antibodies (ANCA). (PubMed id 11064672)9 Paspaliaris B....Savige J. (2000)
  497. Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK) (PubMed id 10824890)9 Lindgren S....Wieslander J. (2000)
  498. Antineutrophil cytoplasmic antibodies (ANCA) and systemic vasculitis: update of assays, immunopathogenesis, controversies, and report of a novel de novo ANCA-associated vasculitis after kidney transplantation. (PubMed id 10805352)9 Schultz D.R. and Diego J.M. (2000)
  499. What you should know about PR3-ANCA. Evidence for the role of T cells in the pathogenesis of systemic vasculitis. (PubMed id 11094438)9 Clayton A.R. and Savage C.O. (2000)
  500. Effect of DNase on the activity of neutrophil elastase, cathepsin G and proteinase 3 in the presence of DNA. (PubMed id 10812064)9 Duranton J....Bieth J.G. (2000)
  501. Characterisation of autoantibodies to neutrophil granule constituents among patients with reactive arthritis, rheumatoid arthritis, and ulcerative colitis. (PubMed id 11053069)9 Locht H....Wiik A. (2000)
  502. Antiproteinase 3- and antimyeloperoxidase-associated vasculitis. (PubMed id 10844589)9 Franssen C.F....Tervaert J.W. (2000)
  503. Evaluation of antineutrophil cytoplasmic antibody seroconversion induced by minocycline, sulfasalazine, or penicillamine. (PubMed id 11083272)9 Choi H.K....Merkel P.A. (2000)
  504. What you should know about PR3-ANCA. An introduction. (PubMed id 11094436)9 Wiik A. (2000)
  505. Effect of the serine protease inhibitor N-tosyl-l-phenylalanine-chloromethyl ketone (TPCK) on MCF-7 mammary tumour cells growth and differentiation. (PubMed id 10772776)9 Horman S....Galand P. (2000)
  506. Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study. (PubMed id 11014352)9 Boomsma M.M....Tervaert J.W. (2000)
  507. Contribution of immunofluorescence to the identification and characterization of anti-neutrophil cytoplasmic autoantibodies. The role of different fixatives. (PubMed id 11138332)9 Radice A....Sinico R.A. (2000)
  508. Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis. (PubMed id 10766165)9 Johnson D.E....Rabinowich H. (2000)
  509. Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates. (PubMed id 10882012)9 Kuang R....Groutas W.C. (2000)
  510. Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis. (PubMed id 10691933)9 Tse W.Y....Adu D. (2000)
  511. A case of relapse of C-ANCA-associated glomerulonephritis in post-transplant patients. (PubMed id 11092351)9 Oka K....Hori M. (2000)
  512. Parvovirus B19 infection associated with the production of anti-neutrophil cytoplasmic antibody (ANCA) and anticardiolipin antibody (aCL). (PubMed id 11035424)9 Chou T.N....Tsay G.J. (2000)
  513. Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide. (PubMed id 10976518)9 He S....Groutas W.C. (2000)
  514. How and why should we detect ANCA? (PubMed id 11072609)9 Segelmark M....Wieslander J. (2000)
  515. Activation of progelatinase B by membranes of human polymorphonuclear granulocytes. (PubMed id 10722050)9 Kolkenbrock H....Ulbrich N. (2000)
  516. [Microscopic polyangiitis] (PubMed id 10896971)9 Venetz J.P. and Rossert J. (2000)
  517. Restriction in V kappa gene use and antigen selection in anti-myeloperoxidase response in mice. (PubMed id 11034396)9 Jethwa H.S....Nachman P.H. (2000)
  518. A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia. (PubMed id 10363991)9 Molldrem J.J....Davis M.M. (1999)
  519. What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications. (PubMed id 10456261)9 Kallenberg C.G. and Tervaert J.W. (1999)
  520. A latex slide agglutination test for rapid detection of antimyeloperoxidase antibody. (PubMed id 10674037)9 Ko K.H....Lawton J.W. (1999)
  521. Recombinant human Monocyte/Neutrophil elastase inhibitor protects rat lungs against injury from cystic fibrosis airway secretions. (PubMed id 9870919)9 Rees D.D....Remold-O'Donnell E. (1999)
  522. Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis. (PubMed id 10469064)9 Locht H....KihlstrAPm E. (1999)
  523. In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis. (PubMed id 10464553)9 Muller Kobold A.C....Tervaert J.W. (1999)
  524. Eosinophilia in Wegener's granulomatosis. (PubMed id 10559120)9 Potter M.B....Finger D.R. (1999)
  525. Wegener's granulomatosis associated with renal cell carcinoma. (PubMed id 10211890)9 Tatsis E....Gross W.L. (1999)
  526. No association between neutrophil FcgammaRIIa allelic polymorphism and anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis. (PubMed id 10403936)9 Tse W.Y....Adu D. (1999)
  527. Seroprevalence and disease association of antineutrophil cytoplasmic autoantibodies and antigens in HIV infection. (PubMed id 10219637)9 Cornely O.A....Schrappe M. (1999)
  528. The role of alpha1 -antitrypsin Deficiency in the Pathogenesis of Antineutrophil Cytoplasmic Antibodies Associated Systemic Necrotizing Vasculitides. (PubMed id 18212413)9 Alzouki A.N. (1999)
  529. [The diagnostic significance of antineutrophil cytoplasmic antibodies in ulcerative colitis] (PubMed id 11798679)9 Liu X....Liu N. (1999)
  530. The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules. (PubMed id 10614782)9 Cowland J.B. and Borregaard N. (1999)
  531. The prevalence and clinical significance of alpha 1-antitrypsin deficiency (PiZ) and ANCA specificities (proteinase 3, BPI) in patients with ulcerative colitis. (PubMed id 10579117)9 Elzouki A.N....Lindgren S. (1999)
  532. Alternating antineutrophil cytoplasmic antibody speci ficity: drug-induced vasculitis in a patient with Wegener's granulomatosis. (PubMed id 10025935)9 Choi H.K....Niles J.L. (1999)
  533. Anti-PR-3 antibodies induce endothelial IL-8 release. (PubMed id 10583443)9 Mayet W....Neurath M. (1999)
  534. Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response. (PubMed id 9463400)9 Sibelius U....Grimminger F. (1998)
  535. Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. (PubMed id 9864022)9 Hiemstra P.S....Stolk J. (1998)
  536. Cationic proteins of neutrophil azurophilic granules: protein-protein interaction and blockade of NADPH oxidase activation. (PubMed id 9500517)9 Tal T....Irit A. (1998)
  537. Endothelial derived vasoactive factors and leukocyte derived inflammatory mediators in subjects with asymptomatic atherosclerosis. (PubMed id 9855370)9 Anwaar I....LindgAorde F. (1998)
  538. The presence of cytoplasmic antineutrophil cytoplasmic antibodies (C-ANCA) in the course of subacute bacterial endocarditis with glomerular involvement, coincidence or association? (PubMed id 9491280)9 Subra J.F....Chevailler A. (1998)
  539. SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis. (PubMed id 9727750)9 Kuijpers A.L....Schalkwijk J. (1998)
  540. Clinical spectrum associated with positive ANCA titres in 94 consecutive patients: is there a relation with PR-3 negative c-ANCA and hypergammaglobulinaemia? (PubMed id 9640128)9 Blockmans D....Bobbaers H. (1998)
  541. The appropriate use of antineutrophil cytoplasmic antibody (ANCA) testing in rheumatic diseases. (PubMed id 9588276)9 Teo D.L. (1998)
  542. Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene. (PubMed id 9630619)9 Zeng W.... Remold-O'Donnell E. (1998)
  543. Prevalence and clinical significance of anti-lactoferrin autoantibodies in inflammatory bowel diseases and primary sclerosing cholangitis. (PubMed id 9781375)9 Roozendaal C....Kallenberg C.G. (1998)
  544. Fibroblast and epidermal growth factor receptor expression in Xenopus oocytes displays distinct calcium oscillatory patterns. (PubMed id 9739176)9 Browaeys-Poly E....Vilain J.P. (1998)
  545. Antineutrophil cytoplasmic autoantibodies (ANCA) and their target antigens in Chinese patients with lupus nephritis. (PubMed id 9829484)9 Zhao M.H....Wang H.Y. (1998)
  546. Escherichia coli and Proteus mirabilis inhibit the perinuclear but not the circulating antineutrophil cytoplasmic antibody reaction. (PubMed id 9648994)9 Yang P....JAornerot G. (1998)
  547. Identification, origins and the diurnal role of the principal serine protease inhibitors in human tear fluid. (PubMed id 9561826)9 Sathe S....Sack R.A. (1998)
  548. Affinity chromatography of serine proteases on the triazine dye ligand Cibacron Blue F3G-A. (PubMed id 9832358)9 Koch C....Houen G. (1998)
  549. Truncation of Sp1 transcription factor by myeloblastin in undifferentiated HL60 cells. (PubMed id 9525470)9 Rao J....Studzinski G.P. (1998)
  550. Antineutrophil cytoplasmic autoantibodies (ANCA) in children with cystic fibrosis. (PubMed id 9650098)9 SedivA! A....Dunn A.C. (1998)
  551. Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold. (PubMed id 9125494)9 Groutas W.C....Prakash O. (1997)
  552. Anti-neutrophil cytoplasmic antibody (ANCA) in malaria is directed against cathepsin G. (PubMed id 9353147)9 Yahya T.M....Bayoumi R. (1997)
  553. Structural analysis of human antibodies to proteinase 3 from patients with Wegener granulomatosis. (PubMed id 9218586)9 Sibilia J....Mariette X. (1997)
  554. Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors. (PubMed id 9294107)9 Ralston D.R....Wewers M.D. (1997)
  555. Laboratory findings in the vasculitides. (PubMed id 9220083)9 Kallenberg C.G. (1997)
  556. HLA genes in ANCA-associated vasculitides. (PubMed id 9493788)9 Griffith M.E. and Pusey C.D. (1997)
  557. Alpha-1-antitrypsin phenotyping in ANCA-associated diseases: one of several arguments for protease/antiprotease imbalance in systemic vasculitis. (PubMed id 9493789)9 Esnault V.L....SesboA1Ac R. (1997)
  558. Incidence and studies on antigenic specificities of antineutrophil-cytoplasmic autoantibodies (ANCA) in poststreptococcal glomerulonephritis. (PubMed id 9021233)9 Ardiles L.G....Mezzano S.A. (1997)
  559. Induction of apoptosis without differentiation by ret inoic acid in PLB-985 cells requires the activation of both RAR and RXR. (PubMed id 9345016)9 Monczak Y....Miller W.H. (1997)
  560. Systemic necrotizing vasculitis. (PubMed id 9220078)9 Gross W.L. (1997)
  561. An enzyme immunoassay for polymorphonuclear leucocyte-mediated fibrinogenolysis. (PubMed id 9061309)9 Bos R....Nieuwenhuizen W. (1997)
  562. Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease. (PubMed id 9155585)9 Walmsley R.S....Lockwood C.M. (1997)
  563. Leukocyte activation in atherosclerosis: correlation with risk factors. (PubMed id 9180248)9 Elneihoum A.M....Ohlsson K. (1997)
  564. Extremely low levels of epidermal skin-derived antileucoproteinase/elafin in a patient with impetigo herpetiformis. (PubMed id 9274639)9 Kuijpers A.L....de Jong E.M. (1997)
  565. Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units. (PubMed id 9326217)9 Molldrem J.J....Barrett A.J. (1997)
  566. Purification of Wegener's granulomatosis autoantigen, proteinase 3, from neutrophils by Triton X-114 extraction of azurophilic granules. (PubMed id 9367512)9 Heegaard N.H....Klattschou D. (1997)
  567. Naturally processed tissue- and differentiation stage-specific autologous peptides bound by HLA class I and II molecules of chronic myeloid leukemia blasts. (PubMed id 9389712)9 Papadopoulos K.P....Harris P.E. (1997)
  568. Detection of anti-neutrophil cytoplasmic antibodies after acute Plasmodium falciparum malaria. (PubMed id 8770517)9 Wenisch C....Rumpold H. (1996)
  569. Expression of the human autoantigen of Wegener's granulomatosis (PR3) in a baculovirus expression system. (PubMed id 8604978)9 Szymkowiak C.H....Gross W.L. (1996)
  570. Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation. (PubMed id 8879231)9 Grimminger F....Sibelius U. (1996)
  571. Autoantibodies and target antigens in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. (PubMed id 8893375)9 Savige J.A....Buchanan R.R. (1996)
  572. Immunologic markers for differentiation of autoimmune responses. (PubMed id 8934922)9 Williams R.C. (1996)
  573. The diagnostic and prognostic significance of ANCA. (PubMed id 8903094)9 Lesavre P. (1996)
  574. Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia. (PubMed id 8823304)9 Pfundt R....Schalkwijk J. (1996)
  575. Human proteinase-3 expression is regulated by PU.1 in conjunction with a cytidine-rich element. (PubMed id 8943304)9 Sturrock A....Hoidal J.R. (1996)
  576. Respiratory failure in ANCA-associated vasculitis. (PubMed id 8697833)9 ter Maaten J.C....Hoorntje S.J. (1996)
  577. Azurocidin is a novel antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in systemic vasculitis. (PubMed id 8608637)9 Zhao M.H. and Lockwood C.M. (1996)
  578. [Antineutrophil cytoplasmic antibodies and nonspecific ulcerative colitis] (PubMed id 9110485)9 Rojas G....Mezzano S. (1996)
  579. Expression of SKALP/elafin during wound healing in human skin. (PubMed id 8844125)9 van Bergen B.H....Schalkwijk J. (1996)
  580. Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells. (PubMed id 8839835)9 Molldrem J....Barrett A.J. (1996)
  581. Monoclonal antibody WGM1 directed against proteinase 3: an immunohistochemical marker for naphthol ASD chloroacetate. (PubMed id 8876637)9 Braun M.G....Feller A.C. (1996)
  582. Anti-neutrophil cytoplasmic antibodies in patients with chromomycosis. (PubMed id 8913648)9 Galperin C....Gershwin M.E. (1996)
  583. [ANCA-associated forms of vasculitis] (PubMed id 9065053)9 Helmchen U....Prall F. (1996)
  584. Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus. (PubMed id 8670594)9 Spronk P.E....Kallenberg C.G. (1996)
  585. Pathogenic role of anti-endothelial cell antibodies in vasculitis. An idiotypic experimental model. (PubMed id 8648146)9 Damianovich M....Shoenfeld Y. (1996)
  586. Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases. (PubMed id 8841320)9 Elneihoum A.M....Ohlsson K. (1996)
  587. Antibodies to proteinase 3 mediate expression of vascular cell adhesion molecule-1 (VCAM-1). (PubMed id 8565309)9 Mayet W.J....Meyer zum BA1schenfelde K.H. (1996)
  588. Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis. (PubMed id 7847352)9 Mrowka C....Thoenes G.H. (1995)
  589. Anti-neutrophil cytoplasmic antibodies in chronic inflammatory bowel disease. Prevalence and diagnostic role. (PubMed id 7481534)9 Hertervig E....Nilsson A. (1995)
  590. Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration. (PubMed id 7554378)9 Blank M....Shoenfeld Y. (1995)
  591. Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus. (PubMed id 7534707)9 Wong S.N....Dillon M.J. (1995)
  592. Antineutrophil cytoplasmic antibodies: major autoantigens, pathophysiology, and disease associations. (PubMed id 8650585)9 Schultz D.R. and Tozman E.C. (1995)
  593. Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study. (PubMed id 7796046)9 Groutas W.C....Kim E.H. (1995)
  594. Clinical correlates and substrate specificities of antibodies exhibiting neutrophil nuclear reactivity--a methodological study. (PubMed id 7499888)9 Bang la Cour B....Baslund B. (1995)
  595. [Clinical and pathogenetic aspects of kidney damage associated with neutrophilic cytoplasm antibodies] (PubMed id 7626983)9 Mukhin N.A....Makar'iants M.L. (1995)
  596. Antineutrophil cytoplasmic antibodies in reactive arthritis. (PubMed id 8835566)9 Locht H....Skogh T. (1995)
  597. Effect of tumor necrosis factor-induced integrin activation on Fc gamma receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies. (PubMed id 7579414)9 Reumaux D....Verhoeven A.J. (1995)
  598. Levels of skin-derived antileukoproteinase (SKALP)/elafin in serum correlate with disease activity during treatment of severe psoriasis with cyclosporin A. (PubMed id 7829874)9 Alkemade H.A....Schalkwijk J. (1995)
  599. Autoantibody profile in the sera of women with hyperprolactinemia. (PubMed id 7576002)9 Buskila D....Shoenfeld Y. (1995)
  600. Proteolysis of classic anti-neutrophil cytoplasmic autoantibodies (C-ANCA) by neutrophil proteinase 3. (PubMed id 7621597)9 Dolman K.M....Goldschmeding R. (1995)
  601. Primary SjAPgren's syndrome and primary biliary cirrhosis: differences and similarities in the autoantibody profile. (PubMed id 7586784)9 Tishler M....Shoenfeld Y. (1995)
  602. Characterization and chromosomal localization of ELANH2, the gene encoding human monocyte/neutrophil elastase inhibitor. (PubMed id 8530031)9 Evans E....Remold-O'Donnell E. (1995)
  603. Multiple autoantibodies in patients with silicone breast implants. (PubMed id 7612152)9 Bar-Meir E....Blank M. (1995)
  604. Immunocytochemical and flow cytometric detection of p roteinase 3 (myeloblastin) in normal and leukaemic myeloid cells. (PubMed id 7873374)9 Dengler R....Emmerich B. (1995)
  605. Oncoproteins and tumor progression in papillary thyroid carcinoma: presence of epidermal growth factor receptor, c-erbB-2 protein, estrogen receptor related protein, p21-ras protein, and proliferation indicators in relation to tumor recurrences and patient survival. (PubMed id 8635070)9 Akslen L.A. and Varhaug J.E. (1995)
  606. 28-kDa mammalian heat shock protein, a novel substrate of a growth regulatory protease involved in differentiation of human leukemia cells. (PubMed id 7836350)9 Spector N.L....Luedke E. (1995)
  607. [Effect of translocation t(15;17) on the gene express ion regulation of myeloblastin during all trans retinoic acid induced myeloid d ifferentiation in human leukemic cells] (PubMed id 8564566)9 Ballerini P....Cayre Y.E. (1995)
  608. Studies of the release and turnover of a human neutrophil lipocalin. (PubMed id 8633182)9 Axelsson L....Ohlsson K. (1995)
  609. Occurrence of antineutrophil cytoplasmic and antineutrophil (peri)nuclear antibodies in rheumatoid arthritis. (PubMed id 8596141)9 Bosch X....Urbano-MA!rquez A. (1995)
  610. In vitro processing of human tumor necrosis factor-al pha. (PubMed id 7559538)9 Robache-Gallea S....Roman-Roman S. (1995)
  611. Immunodiagnostic and pathophysiologic aspects of anti neutrophil cytoplasmic antibodies in vasculitis. (PubMed id 7718417)9 Gross W.L. and Csernok E. (1995)
  612. Detection of anti-neutrophil cytoplasmic antibodies by immunoprecipitation. (PubMed id 7554581)9 Lucena-Fernandes F....MAcnard H.A. (1995)
  613. A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells. (PubMed id 7931077)9 Franzoso G....Siebenlist U.K. (1994)
  614. Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte-macrophage cell lineage. (PubMed id 8090034)9 Abrink M....Hellman L. (1994)
  615. Eosinophil peroxidase differs from neutrophil myeloperoxidase in its ability to bind antineutrophil cytoplasmic antibodies reactive with myeloperoxidase. (PubMed id 7920015)9 Sullivan S....Broide D.H. (1994)
  616. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): a Fc gamma RII-dependent process. (PubMed id 7955533)9 Mulder A.H....Kallenberg C.G. (1994)
  617. Anti-neutrophil cytoplasmic antibodies (ANCA) in sera from patients with inflammatory bowel disease (IBD). Relation to disease pattern and disease activity. (PubMed id 7510606)9 Broekroelofs J....Kallenberg C.G. (1994)
  618. SKALP/elafin is an inducible proteinase inhibitor in human epidermal keratinocytes. (PubMed id 7983189)9 Alkemade J.A....Schalkwijk J. (1994)
  619. Antimicrobial proteins with homology to serine proteases. (PubMed id 7768154)9 Gabay J.E. (1994)
  620. Anti-neutrophil cytoplasmic antibodies: a new class of autoantibodies in glomerulonephritis, vasculitis and other inflammatory disorders. (PubMed id 7838242)9 Tervaert J.W....Kallenberg C.G. (1994)
  621. Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3. (PubMed id 7925979)9 Padrines M....Baggiolini M. (1994)
  622. Use of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient population. (PubMed id 7915885)9 Li P.K....Lai K.N. (1994)
  623. Alpha 1-antitrypsin phenotypes in patients with anti-neutrophil cytoplasmic antibody-positive vasculitis. (PubMed id 7874861)9 Lhotta K....KAPnig P. (1994)
  624. Absence of antineutrophil cytoplasmic antibodies in giant cell arteritis. (PubMed id 8064728)9 Baranger T.A....Esnault V.L. (1994)
  625. Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma. (PubMed id 7965407)9 Alkemade H.A....Schalkwijk J. (1994)
  626. [Wegener's granulomatosis] (PubMed id 7933591)9 Yoshida M. (1994)
  627. Elastase inhibitor elafin is a new type of proteinase inhibitor which has a transglutaminase-mediated anchoring sequence termed 'cementoin'. (PubMed id 7914520)9 Nara K....Hirose S. (1994)
  628. Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides. (PubMed id 8296655)9 Csernok E....Gross W.L. (1993)
  629. Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement. (PubMed id 8352807)9 Groutas W.C....McClenahan J.J. (1993)
  630. Anti-neutrophil cytoplasmic antibodies in giant cell arteritis and polymyalgia rheumatica. (PubMed id 8296636)9 Cats H.A....Kallenberg C.G. (1993)
  631. Antineutrophil-cytoplasmic-autoantibodies in poststreptococcal nephritis. (PubMed id 8296654)9 Mezzano S....Caorsi I. (1993)
  632. Localization of the gene encoding proteinase-3 (the Wegener's granulomatosis autoantigen) to human chromosome band 19p13.3. (PubMed id 8508676)9 Sturrock A.B....Le Beau M.M. (1993)
  633. Autoantibodies to neutrophil cytoplasmic enzymes in Felty's syndrome. (PubMed id 7689047)9 Coremans I.E....Breedveld F.C. (1993)
  634. Antineutrophil cytoplasmic antibodies in rheumatoid arthritis. Characterization and clinical correlations. (PubMed id 8343182)9 Mulder A.H....Kallenberg C.G. (1993)
  635. ANCA in systemic vasculitides, collagen vascular diseases, rheumatic disorders and inflammatory bowel diseases. (PubMed id 8296613)9 Hauschild S....Gross W.L. (1993)
  636. In vitro interactions of c-ANCA (antibodies to proteinase 3) with human endothelial cells. (PubMed id 8296598)9 Mayet W.J....Meyer zum BA1schenfelde K.H. (1993)
  637. Wegener's granulomatosis and antineutrophil cytoplasm ic autoantibodies. (PubMed id 8239356)9 Batsakis J.G. and el-Naggar A.K. (1993)
  638. Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (PubMed id 8432453)9 Peen E....Skogh T. (1993)
  639. Anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver disease. (PubMed id 8296673)9 Mulder A.H....Kallenberg C.G. (1993)
  640. Inhibition of proteinase 3 activity by peptides derived from human epidermis. (PubMed id 8296675)9 Wiedow O....Christophers E. (1993)
  641. Clinical spectrum associated with ANCA of defined antigen specificities in 98 selected patients. (PubMed id 7681736)9 Geffriaud-Ricouard C....Lesavre P. (1993)
  642. Neutrophil cytoplasmic autoantibodies after liver transplantation in patients with primary sclerosing cholangitis. (PubMed id 8301047)9 Haagsma E.B....Kallenberg C.G. (1993)
  643. Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases. (PubMed id 8444414)9 Mulder A.H....Kallenberg C.G. (1993)
  644. Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis. (PubMed id 8353286)9 Mayet W.J....Meyer zum BA1schenfelde K.H. (1993)
  645. Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. (PubMed id 8103148)9 Dolman K.M....Goldschmeding R. (1993)
  646. [Wegener's granulomatosis and ANCA-associated vasculitis: pathogenic role of autoantigens, autoantibodies, and cytokines] (PubMed id 8344692)9 Kekow J....Gross W.L. (1993)
  647. Association of IgM with IgG ANCA in patients presenting with pulmonary hemorrhage. (PubMed id 1351955)9 Esnault V.L....Lockwood C.M. (1992)
  648. Interference of Wegener's granulomatosis autoantibodies with neutrophil Proteinase 3 activity. (PubMed id 1458677)9 van de Wiel B.A....Goldschmeding R. (1992)
  649. Anti-neutrophil cytoplasm antibodies, anti-GBM antibodies and anti-dsDNA antibodies in glomerulonephritis. (PubMed id 1478249)9 Bygren P....Wieslander J. (1992)
  650. Immunodiagnostic aspects of autoantibodies against my eloperoxidase. (PubMed id 1316247)9 Ulmer M....Gross W.L. (1992)
  651. Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders. (PubMed id 1466365)9 Kallenberg C.G....Tervaert J.W. (1992)
  652. Human neutrophil proteinase 3: mapping of the substra te binding site using peptidyl thiobenzyl esters. (PubMed id 1445363)9 Brubaker M.J....Rao N.V. (1992)
  653. [Anti-cytoplasmic antibodies of polynucle or 'ANCA'. A new class of autoantibodies] (PubMed id 1411180)9 NoAl L.H. (1992)
  654. Stimulation of human polymorphonuclear leukocytes by recombinant human interleukin-1 beta. (PubMed id 1627264)9 Bergenfeldt M....Ohlsson K. (1992)
  655. Substrate and inhibitor studies on proteinase 3. (PubMed id 1551417)9 Kam C.M....Powers J.C. (1992)
  656. A human renal cancer line as a new antigen source for the detection of antibodies to cytoplasmic and nuclear antigens in sera of patients with Wegener's granulomatosis. (PubMed id 1717605)9 Mayet W.J....Meyer zum BA1schenfelde K.H. (1991)
  657. Proteinase-3 (PR-3): a polymorphonuclear leukocyte se rine proteinase. (PubMed id 2064249)9 Rao N.V....Hoidal J.R. (1991)
  658. Regulation of cystatin C activity by serine proteinases. (PubMed id 1801727)9 Abrahamson M....Ohlsson K. (1991)
  659. Proteinase 3, the target antigen of anticytoplasmic antibodies circulating in Wegener's granulomatosis. Immunolocalization in normal and pathologic tissues. (PubMed id 1656761)9 Braun M.G....MA1ller-Hermelink H.K. (1991)
  660. [Distribution pattern of proteinase 3 in Wegener's granulomatosis and other vasculitic diseases] (PubMed id 2060965)9 Braun M.G....Gross W.L. (1991)

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Entrez Gene: 5657 HGNC: 9495 AceView: PRTN3 Ensembl:ENSG00000196415 euGenes: HUgn5657
ECgene: PRTN3 H-InvDB: PRTN3

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