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PRTN3 Gene

protein-coding   GIFtS: 62
GCID: GC19P000840

Proteinase 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteinase 31 2     C-ANCA Antigen2 3
AGP72 3 5     neutrophil1
myeloblastin1 2     Serine Proteinase1
Wegener Granulomatosis Autoantigen1 2     ACPA2
Leukocyte Proteinase 32 3     C-ANCA2
Neutrophil Proteinase 42 3     CANCA2
Wegener Autoantigen2 3     MBT2
MBN2 3     NP42
NP-42 3     Azurophil Granule Protein 72
P292 3     Serine Proteinase, Neutrophil2
PR-32 3     EC 3.4.21.763
PR32 3     EC 3.4.218

External Ids:    HGNC: 94951   Entrez Gene: 56572   Ensembl: ENSG000001964157   OMIM: 1770205   UniProtKB: P241583   

Export aliases for PRTN3 gene to outside databases

Previous GC identifers: GC19P000922 GC19P000910 GC19P000780 GC19P000793 GC19P000498 GC19P000794 GC19P000610


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRTN3 Gene:
PRTN3 (proteinase 3) is a protein-coding gene. Diseases associated with PRTN3 include subacute bacterial endocarditis, and wegener's granulomatosis. GO annotations related to this gene include serine-type peptidase activity and enzyme binding. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin,
and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to
hamsters

Gene Wiki entry for PRTN3 (Proteinase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  NT_187622.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRTN3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRTN3 promoter sequence
   Search Chromatin IP Primers for PRTN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PRTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRTN3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000840:  view genomic region     (about GC identifiers)

Start:
840,963 bp from pter      End:
848,175 bp from pter
Size:
7,213 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158 (See protein sequence)
Recommended Name: Myeloblastin precursor  
Size: 256 amino acids; 27807 Da
Sequence caution: Sequence=AAA36342.1; Type=Frameshift; Positions=34, 39; Sequence=CAA39598.1; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for PRTN3:
1FUJ (3D)    
Secondary accessions: P15637 P18078 Q4VB08 Q4VB09 Q6LBM7 Q6LBN2 Q9UD25 Q9UQD8

Explore the universe of human proteins at neXtProt for PRTN3: NX_P24158

Explore proteomics data for PRTN3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn129, Asn174
  • Selected DME Specific Peptides for PRTN3 (P24158) (see all 5)
     GDSGGPL  SGGPLIC  VLTAAHC  PHSRPYMA 


    See PRTN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002768.3  
    ENSEMBL proteins: 
     ENSP00000234347   ENSP00000475174  

    PRTN3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PRTN3
    Browse Proteins at Cloud-Clone Corp.

    PRTN3 Antibody Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P24158

    ProtoNet protein and cluster: P24158

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
    Similarity: Belongs to the peptidase S1 family. Elastase subfamily
    Similarity: Contains 1 peptidase S1 domain


    PRTN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRTN3_HUMAN, P24158
    Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin,
    and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to
    hamsters
    Catalytic activity: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- -Xaa- > -Val- -Xaa-

         Genatlas biochemistry entry for PRTN3:
    proteinase 3,myeloblastin,Wegener autoantigen,responsive to CSF3,stimulated by SPI1,MYB,inducing factor
    independent growth of hematopoietic cells

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.761

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS2679910
    GO:0019899enzyme binding IPI17712045
         
    PRTN3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRTN3:
     Decreased viability  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prtn3):
     hematopoietic system  immune system 

    PRTN3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Elane/Prtn3Elane/tm1Deje for PRTN3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRTN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRTN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRTN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRTN3

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    Predesigned siRNA for gene silencing in human, mouse, rat PRTN3

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    GenScript: all cDNA clones in your preferred vector: PRTN3 (NM_002777)
    Sino Biological Human cDNA Clone for PRTN3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5
    extracellular3
    lysosome3
    vacuole3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA17712045
    GO:0005886plasma membrane IDA17712045
    GO:0031012colocalizes with extracellular matrix IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    PRTN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRTN3 About    
    See pathways by source

    SuperPathContained pathways About
    1C-MYB transcription factor network
    C-MYB transcription factor network


    1 BioSystems Pathway for PRTN3
        C-MYB transcription factor network



        Pathway & Disease-focused RT2 Profiler PCR Array including PRTN3: 
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRTN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for PRTN3 (P241582, 3 ENSP000002343474) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0008284positive regulation of cell proliferation TAS2598267
    GO:0030574collagen catabolic process IEA--
    GO:0050765negative regulation of phagocytosis IDA17712045
    GO:0097029mature dendritic cell differentiation IDA16478888

    PRTN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PRTN3
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRTN3

    Selected Novoseek inferred chemical compound relationships for PRTN3 gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 75.5 224 2033050 (4), 1400430 (3), 11272267 (3), 1681549 (3) (see all 99)
    propylthiouracil 63.2 5 10025935 (1), 8103148 (1), 17350787 (1), 17161817 (1)
    acpa 58.3 5 1316247 (1), 2240162 (1), 1656761 (1), 1688612 (1)
    sulf 55.6 3 7586784 (1), 7612152 (1)
    aebsf 53.6 1 12354776 (1)
    3,4-dichloroisocoumarin 50.6 4 14525961 (1), 9067256 (1), 1551417 (1)
    pmsf 40.3 5 12960243 (1), 8033421 (1), 9500517 (1)
    fmlp 32.9 1 10498622 (1)
    phthalimide 32.6 4 7796053 (2), 8806743 (2)
    n-formylmethionyl-leucylphenylalanine 29.6 1 10614782 (1)



    PRTN3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRTN3 gene: 
    NM_002777.3  

    Unigene Cluster for PRTN3:

    Proteinase 3
    Hs.928  [show with all ESTs]
    Unigene Representative Sequence: FN647680
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234347(uc002lqa.1) ENST00000544537(uc021umb.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PRTN3
      QuantiFast Probe-based Assays in human, mouse, rat PRTN3

    Additional mRNA sequence: 

    BC096183.1 BC096184.3 BC096185.3 BC096186.3 FN647680.1 M29142.1 M75154.1 X55668.1 
    X56132.1 X56606.1 

    1 DOTS entry:

    DT.310571 

    Selected AceView cDNA sequences (see all 27):

    BV185512 BV199984 BV199995 X56606 BP428518 BI029018 BP429701 BI029214 
    BV199994 X56132 BP428468 BF893078 NM_002777 X55668 M75154 M29142 
    BE831590 AI273534 BF898648 BQ335282 BI026807 AW966814 BI028421 D19823 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRTN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRTN3 Expression
    About this image


    PRTN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 8 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone marrow-derived hematopoietic stem cells (family)
             Bone Marrow CD34+ Cells   
             bone marrow mononuclear cells   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             bone marrow   
     
     Liver (Hepatobiliary System)
             Fetal Liver CD34+ Cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    PRTN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRTN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.928
        Pathway & Disease-focused RT2 Profiler PCR Array including PRTN3: 
              Antibacterial Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRTN3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prtn31 , 5 proteinase 31, 5 73.19(n)1
    68(a)1
      10 (39.72 cM)5
    191521  NM_011178.21  NP_035308.21 
     798744765 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prtn31 proteinase 3 55.61(n)
    52.8(a)
      448597  NM_001006846.1  NP_001006847.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0071421 AgaP_AGAP007142 47.76(n)
    38.94(a)
      1269964  XM_308619.3  XP_308619.3 


    ENSEMBL Gene Tree for PRTN3 (if available)
    TreeFam Gene Tree for PRTN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRTN3 gene
    GZMH2  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  AZU12  
    GZMM2  GZMA2  GZMB2  
    Selected SIMAP similar genes for PRTN3 using alignment to 3 protein entries:     PRTN3_HUMAN (see all proteins) (see all similar genes):
    ELANE    ELA2    AZU1    PRSS1    CTSG    CMA1
    PRSS2    TRY8    PRSS3    CTRL    GZMK    LPA
    KLK4    DF    KLK6    APS    CFD    CELA3A

    PRTN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRTN3 (see all 334)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492124241,2
    --839030(+) ATGGGC/TTTCGA 1 -- us2k10--------
    rs1432557671,2
    --839070(+) CGCCCA/GGGACT 1 -- us2k10--------
    rs739198631,2
    C,F--839097(+) GAGGCC/AACCCA 1 -- us2k13Minor allele frequency- A:0.07WA CSA 122
    rs1482964801,2
    C--839147(+) CAGCTC/GTCCTC 1 -- us2k10--------
    rs120521081,2
    C,F,A,H--839158(+) AATGGC/TCCCAA 1 -- us2k122Minor allele frequency- T:0.18NS EA NA WA CSA 2347
    rs1405230041,2
    --839189(+) GACTGA/CGCCCG 1 -- us2k10--------
    rs793612211,2
    F--839193(+) GCGCCC/GGCTGG 1 -- us2k10--------
    rs1380321111,2
    --839269(+) ATACTC/TAGGGG 1 -- us2k10--------
    rs104108261,2
    C,F--839272(+) CTCAGG/TGGGCT 1 -- us2k14Minor allele frequency- T:0.23NA WA CSA 124
    rs621322941,2
    C,F--839298(+) ATTTGG/CAATCA 1 -- us2k13Minor allele frequency- C:0.18NA EA 242

    HapMap Linkage Disequilibrium report for PRTN3 (840963 - 848175 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRTN3 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717797CNV Deletion23290073
    esv2717798CNV Deletion23290073
    nsv470101CNV Loss18288195
    dgv3550n71CNV Loss21882294
    nsv910292CNV Loss21882294
    nsv138320CNV Loss16902084
    dgv3558n71CNV Loss21882294
    dgv3555n71CNV Loss21882294
    dgv3552n71CNV Loss21882294
    dgv3554n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRTN3
    DNA2.0 Custom Variant and Variant Library Synthesis for PRTN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 177020    OMIM disorders: --

    Selected diseases for PRTN3 (see all 92):    
    About MalaCards
    subacute bacterial endocarditis    wegener's granulomatosis    mononeuritis multiplex    mononeuritis
    mononeuropathy    granulomatosis with polyangiitis    rapidly progressive glomerulonephritis    endocarditis
    scleritis    alpha 1-antitrypsin deficiency    vasculitis    relapsing polychondritis
    crescentic glomerulonephritis    mixed connective tissue disease    polyarteritis nodosa    churg-strauss syndrome
    microscopic polyangiitis    cholangitis    pyoderma gangrenosum    glomerulonephritis

    12 diseases from the University of Copenhagen DISEASES database for PRTN3:
    Vasculitis     Hypersensitivity reaction type II disease     Glomerulonephritis     Rheumatoid arthritis
    Polyarteritis nodosa     Scleritis     Sinusitis     Connective tissue disease
    Endocarditis     Ulcerative colitis     Lung disease     Mononeuropathy

    PRTN3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for PRTN3 gene (see all 81)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wegeners granulomatosis 96.5 304 8157982 (3), 15498036 (3), 17005932 (3), 19881350 (3) (see all 99)
    vasculitis 92.8 228 12605707 (4), 16792675 (4), 15958084 (3), 8499060 (2) (see all 99)
    churg-strauss syndrome 85.5 15 12687504 (1), 17521322 (1), 10896971 (1), 8381764 (1) (see all 10)
    glomerulonephritis 81.1 20 10405206 (2), 10844589 (1), 11034396 (1), 11092351 (1) (see all 14)
    glomerulonephritis rapidly progressive 78.9 2 7847352 (1), 9306336 (1)
    vasculitis leukocytoclastic 71.9 8 7626983 (1), 7554378 (1), 11838849 (1), 11208991 (1) (see all 6)
    polyarteritis nodosa 64.4 6 7754755 (2), 7907475 (1)
    pulmonary hemorrhage 57.2 1 1351955 (1)
    inflammation 55.5 43 10101005 (2), 7829874 (1), 10471824 (1), 11272269 (1) (see all 28)
    autoimmune diseases 55.2 8 14736010 (1), 10720938 (1), 16026591 (1), 18953353 (1) (see all 7)

    Genetic Association Database (GAD): PRTN3
    Human Genome Epidemiology (HuGE) Navigator: PRTN3 (7 documents)

    Export disorders for PRTN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PRTN3 gene, integrated from 10 sources (see all 670) (see top 10):
    (articles sorted by number of sources associating them with PRTN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. (PubMed id 2258701)1, 2, 3, 9 Campanelli D....Gabay J.E. (J. Exp. Med. 1990)
    2. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. (PubMed id 2033050)1, 2, 9 Rao N.V....Hoidal J.R. (J. Biol. Chem. 1991)
    3. Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. (PubMed id 1400430)1, 2, 9 Sturrock A.B.... Hoidal J.R. (J. Biol. Chem. 1992)
    4. Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism. (PubMed id 16792675)1, 4, 9 Abdgawad M....Segelmark M. (Clin. Exp. Immunol. 2006)
    5. Proteinase 3 gene polymorphisms and Wegener's granulomatosis. (PubMed id 11115080)1, 4, 9 Gencik M....Fricke H. (Kidney Int. 2000)
    6. Wegener autoantigen and myeloblastin are encoded by a single mRNA. (PubMed id 1681549)1, 2, 9 Labbaye C.... Cayre Y.E. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    7. Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme. (PubMed id 2121162)1, 2, 9 Ohlsson K.... Rosengren M. (Biol. Chem. Hoppe-Seyler 1990)
    8. The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. (PubMed id 8757293)1, 2, 9 Fujinaga M.... James M.N.G. (J. Mol. Biol. 1996)
    9. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PubMed id 1518849)1, 2, 9 Zimmer M....Jenne D.E. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    10. Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia. (PubMed id 9924693)1, 2, 9 Clave E.... Barrett A.J. (J. Immunother. 1999)
    11. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. (PubMed id 1688612)1, 2, 9 Ludemann J.... Gross W.L. (J. Exp. Med. 1990)
    12. Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase. (PubMed id 2404977)1, 2, 9 Wilde C.G.... Scott R.W. (J. Biol. Chem. 1990)
    13. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    14. Association study of Wegener granulomatosis and the functionally relevant A645G polymorphism in the bactericidal/permeability increasing protein (BPI) gene. (PubMed id 15686586)1, 4 Jagiello P....Epplen J.T. (Int. J. Immunogenet. 2005)
    15. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    16. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    17. Wegener's autoantigen and leukemia. (PubMed id 2001463)1, 2 Musette P....Kourilsky P. (Blood 1991)
    18. The relation of 29 kD C-ANCA antigen to proteinase 3. (PubMed id 2285532)1, 2 Goldschmeding R.... von dem Borne A.E. (APMIS Suppl. 1990)
    19. Wegener's autoantigen decoded. (PubMed id 2377228)1, 2 Jenne D.E.... Gross W.L. (Nature 1990)
    20. Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin. (PubMed id 2242436)1, 2 Gupta S.K.... Arnaout M.A. (Blood 1990)
    21. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells. (PubMed id 2598267)1, 2 Bories D.... Cayre Y.E. (Cell 1989)
    22. Antibiotic proteins of human polymorphonuclear leukocytes. (PubMed id 2501794)1, 2 Gabay J.E.... Nathan C.F. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    23. Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase. (PubMed id 2679910)1, 2 Niles J.L.... Arnaout M.A. (Blood 1989)
    24. Proteinase 3 is an IL-32 binding protein. (PubMed id 16488976)1, 9 Novick D....Kim S.H. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    25. Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis. (PubMed id 17712045)1, 9 Kantari C....Witko-Sarsat V. (Blood 2007)
    26. Interaction of proteinase 3 with CD11b/CD18 (beta2 integrin) on the cell membrane of human neutrophils. (PubMed id 12960243)1, 9 David A....Aviram I. (J. Leukoc. Biol. 2003)
    27. Elastolysis by proteinase 3 and its inhibition by alpha(1)-proteinase inhibitor: a mechanism for the incomplete inhibition of ongoing elastolysis. (PubMed id 11867344)1, 9 Ying Q.L. and Simon S.R. (Am. J. Respir. Cell Mol. Biol. 2002)
    28. Computational prediction of the binding site of proteinase 3 to the plasma membrane. (PubMed id 18076025)1, 9 Hajjar E....Reuter N. (Proteins 2008)
    29. A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors. (PubMed id 18854317)1, 9 Korkmaz B....Jenne D.E. (J. Biol. Chem. 2008)
    30. High PR3 or ELA2 expression by CD34+ cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects. (PubMed id 17412886)1, 9 Yong A.S....Barrett A.J. (Blood 2007)
    31. Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies. (PubMed id 15331626)1, 9 van Rossum A.P....Kallenberg C.G. (J. Leukoc. Biol. 2004)
    32. Apoptosis-induced proteinase 3 membrane expression is independent from degranulation. (PubMed id 14525959)1, 9 Durant S....Witko-Sarsat V. (J. Leukoc. Biol. 2004)
    33. Membrane expression of proteinase 3 is genetically determined. (PubMed id 12506139)1, 9 Schreiber A....Kettritz R. (J. Am. Soc. Nephrol. 2003)
    34. Cleavage of p21waf1 by proteinase-3, a myeloid-specific serine protease, potentiates cell proliferation. (PubMed id 12354776)1, 9 Witko-Sarsat V....Descamps-Latscha B. (J. Biol. Chem. 2002)
    35. Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant. (PubMed id 12140766)1, 9 Wu C.H....Safa A.R. (Oncogene 2002)
    36. Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways. (PubMed id 12444202)1, 9 Preston G.A....Falk R.J. (J. Am. Soc. Nephrol. 2002)
    37. Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules. (PubMed id 10498622)1, 9 Witko-Sarsat V....Halbwachs-Mecarelli L. (Blood 1999)
    38. Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin. (PubMed id 19494315)1, 9 Kahn R....Karpman D. (J. Immunol. 2009)
    39. Human proteinase 3 (PR3) and its binding molecules: implications for inflammatory and PR3-related autoimmune responses. (PubMed id 17785293)1, 9 MA1ller A....Csernok E. (Ann. N. Y. Acad. Sci. 2007)
    40. Immune functions of proteinase 3. (PubMed id 16167885)1, 9 Sugawara S. (Crit. Rev. Immunol. 2005)
    41. Proteinase 3 sidesteps caspases and cleaves p21(Waf1/Cip1/Sdi1) to induce endothelial cell apoptosis. (PubMed id 14675038)1, 9 Pendergraft W.F....Preston G.A. (Kidney Int. 2004)
    42. Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis. (PubMed id 12191967)1, 9 Rarok A.A....Kallenberg C.G. (J. Am. Soc. Nephrol. 2002)
    43. Functional significance of Asn-linked glycosylation of proteinase 3 for enzymatic activity, processing, targeting, and recognition by anti-neutrophil cytoplasmic antibodies. (PubMed id 17158864)1, 9 Specks U....McDonald C.J. (J. Biochem. 2007)
    44. The presence of membrane Proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558. (PubMed id 15916759)1, 9 David A....Aviram I. (Exp. Cell Res. 2005)
    45. Proteinase-3 induces procaspase-3 activation in the absence of apoptosis: potential role of this compartmentalized activation of membrane-associated procaspase-3 in neutrophils. (PubMed id 15879139)1, 9 Pederzoli M....Witko-Sarsat V. (J. Immunol. 2005)
    46. Proteinase-3 directly activates MMP-2 and degrades gelatin and Matrigel; differential inhibition by (-)epigallocatechin-3-gallate. (PubMed id 12832446)1, 9 Pezzato E....Garbisa S. (J. Leukoc. Biol. 2003)
    47. Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts. (PubMed id 12538645)1, 9 Koehl C....Bieth J.G. (J. Biol. Chem. 2003)
    48. Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates. (PubMed id 12114510)1, 9 Korkmaz B....Gauthier F. (J. Biol. Chem. 2002)
    49. The proteinase 3 (PRTN3) gene is localized on 19p13.3 and is distal to the E2A gene. (PubMed id 8629812)1, 9 Le Coniat M. and Berger R. (Ann. Genet. 1995)
    50. Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia. (PubMed id 12393722)1, 9 Burchert A....Neubauer A. (Blood 2003)
    51. Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. (PubMed id 10339575)1, 9 Coeshott C....Cheronis J. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    52. Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase. (PubMed id 18023421)1, 9 Hajjar E....Reuter N. (FEBS Lett. 2007)
    53. Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase. A kinetic and molecular modeling analysis. (PubMed id 17088257)1, 9 Korkmaz B....Gauthier F. (J. Biol. Chem. 2007)
    54. CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia. (PubMed id 12200377)1, 9 Scheibenbogen C....Keilholz U. (Blood 2002)
    55. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. (PubMed id 11389039)1, 9 SA...Borregaard N. (Blood 2001)
    56. Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis. (PubMed id 7897245)2, 9 Gaskin G.... Pusey C.D. (J. Immunol. Methods 1995)
    57. Structures of human proteinase 3 and neutrophil elastase--so similar yet so different. (PubMed id 20423453)1, 9 Hajjar E....Reuter N. (FEBS J. 2010)
    58. Catalytic activity and inhibition of wegener antigen proteinase 3 on the cell surface of human polymorphonuclear neutrophils. (PubMed id 19447886)1, 9 Korkmaz B....Attucci S. (J. Biol. Chem. 2009)
    59. Membrane-bound proteinase 3 and its receptors: relevance for the pathogenesis of Wegener's Granulomatosis. (PubMed id 19185066)1, 9 Hu N....Kallenberg C.G. (Autoimmun Rev 2009)
    60. NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils. (PubMed id 17244676)1, 9 von Vietinghoff S....Kettritz R. (Blood 2007)
    61. Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway. (PubMed id 16478888)1, 9 Csernok E.... Hellmich B. (Blood 2006)
    62. Membrane proteinase 3 and its interactions within microdomains of neutrophil membranes. (PubMed id 16598772)1, 9 Fridlich R....Aviram I. (J. Cell. Biochem. 2006)
    63. The N-terminal tetrapeptide of neutrophil proteinase 3 causes S-phase arrest in granulopoietic progenitors. (PubMed id 16263417)1, 9 SkAPld S....Olofsson T. (Exp. Hematol. 2005)
    64. Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis. (PubMed id 12010574)1, 9 Brockmann H....Mayet W. (Arthritis Res. 2002)
    65. Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro. (PubMed id 8738804)1, 9 Berger S.P....Daha M.R. (J. Am. Soc. Nephrol. 1996)
    66. The phylogeny of proteinase 3/myeloblastin, the autoantigen in Wegener's granulomatosis, and myeloperoxidase as shown by immunohistochemical studies on human leukemic cell lines. (PubMed id 8261669)1, 9 Muller-BAcrat N....Wiik A. (Clin. Immunol. Immunopathol. 1994)
    67. Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. (PubMed id 23202369)1 Kuckleburg C.J. and Newman P.J. (Arterioscler. Thromb. Vasc. Biol. 2013)
    68. Proteinase 3 activity in sputum from subjects with alpha-1-antitrypsin deficiency and COPD. (PubMed id 22936713)1 Sinden N.J. and Stockley R.A. (Eur. Respir. J. 2013)
    69. Changes in proteinase 3 anti-neutrophil cytoplasm autoantibody levels in early systemic granulomatosis with polyangiitis (Wegener's) may reflect treatment rather than disease activity. (PubMed id 23380137)1 Rasmussen N....Jayne D.R. (Clin. Exp. Rheumatol. 2013)
    70. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). (PubMed id 24052258)1 Mihara K....Hollenberg M.D. (J. Biol. Chem. 2013)
    71. Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation. (PubMed id 22844112)1 Gabillet J....Witko-Sarsat V. (J. Immunol. 2012)
    72. Expression profile of proinflammatory genes in neutrophil-enriched granulocytes stimulated with native anti-PR3 autoantibodies. (PubMed id 22791638)1 Surmiak M....Sanak M. (J. Physiol. Pharmacol. 2012)
    73. Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils. (PubMed id 22266279)1 Kuckleburg C.J....Newman P.J. (J. Immunol. 2012)
    74. Early plasma exchange improves outcome in PR3-ANCA-positive renal vasculitis. (PubMed id 22510451)1 Gregersen J.W....Ivarsen P. (Clin. Exp. Rheumatol. 2012)
    75. PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells. (PubMed id 22952809)1 Tull S.P....Savage C.O. (PLoS ONE 2012)
    76. Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity. (PubMed id 22270365)1 Bae S....Kim S. (J. Biol. Chem. 2012)
    77. KRAS mutation is associated with elevated myeloblastin activity in human lung adenocarcinoma. (PubMed id 22210048)1 Wiedl T....Weder W. (amp 2012)
    78. Proteinase 3 carries small unusual carbohydrates and associates with I+lpha-defensins. (PubMed id 22138257)1 Zoega M....Schou C. (J Proteomics 2012)
    79. Distinct proteinase 3-induced cytokine patterns in WegenerA's granulomatosis, Churg-Strauss syndrome, and healthy controls. (PubMed id 21470489)1 Fagin U....Lamprecht P. (Clin. Exp. Rheumatol. 2011)
    80. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    81. Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation. (PubMed id 21193407)1 Jerke U....Kettritz R. (J. Biol. Chem. 2011)
    82. Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway. (PubMed id 21193404)1 Cosgrove S....McElvaney N.G. (J. Biol. Chem. 2011)
    83. Membrane-bound proteinase 3 and PAR2 mediate phagocytosis of non-opsonized bacteria in human neutrophils. (PubMed id 21700341)1 Kim Y.C....Choi Y. (Mol. Immunol. 2011)
    84. Epitope shift of proteinase-3 anti-neutrophil cytoplasmic antibodies in patients with small vessel vasculitis. (PubMed id 20059480)1 Selga D....Hellmark T. (Clin. Exp. Immunol. 2010)
    85. Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener's granulomatosis. (PubMed id 20530264)1 Kuhl A....Jenne D.E. (J. Immunol. 2010)
    86. Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis. (PubMed id 20155833)1 Cheadle C....Levine S.M. (Arthritis Rheum. 2010)
    87. Natural autoantibodies to myeloperoxidase, proteinase 3, and the glomerular basement membrane are present in normal individuals. (PubMed id 20592714)1 Cui Z....Hellmark T. (Kidney Int. 2010)
    88. Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells. (PubMed id 20828556)1 KAollquist L....Olsson I. (Exp. Cell Res. 2010)
    89. Membrane proteinase 3 (mPR3) expression on neutrophils is not increased in localized Wegener's granulomatosis (WG) and Churg-Strauss syndrome (CSS). (PubMed id 20412702)1 Holle J.U....Csernok E. (Clin. Exp. Rheumatol. 2010)
    90. Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression. (PubMed id 20491791)1 Abdgawad M....Hellmark T. (Clin. Exp. Immunol. 2010)
    91. The role of proteinase 3 (PR3) and the protease-activated receptor-2 (PAR-2) pathway in dendritic cell (DC) maturation of human-DC-like monocytes and murine DC. (PubMed id 20412704)1 Jiang B....Holle J.U. (Clin. Exp. Rheumatol. 2010)
    92. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    93. Antineutrophil cytoplasmic antibody (ANCA) testing of routine sera varies in different laboratories but concordance is greater for cytoplasmic fluorescence (C-ANCA) and myeloperoxidase specificity (MPO-ANCA). (PubMed id 19490915)1 Pollock W....Savige J. (J. Immunol. Methods 2009)
    94. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    95. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    96. ANCA patients have T cells responsive to complementary PR-3 antigen. (PubMed id 18596726)1 Yang J....Preston G.A. (Kidney Int. 2008)
    97. Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3. (PubMed id 17681950)1 Vong L....Perretti M. (J. Biol. Chem. 2007)
    98. Antibodies to proteinase 3 prime human monocytic cells via protease-activated receptor-2 and NF-kappaB for Toll-like receptor- and NOD-dependent activation. (PubMed id 17452051)1 Uehara A....Takada H. (Mol. Immunol. 2007)
    99. Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritis. (PubMed id 17534941)1 van der Helm-van Mil A.H....Toes R.E. (Arthritis Rheum. 2007)
    100. Increased membrane expression of proteinase 3 during neutrophil adhesion in the presence of anti proteinase 3 antibodies. (PubMed id 17634439)1 Brachemi S....Halbwachs-Mecarelli L. (J. Am. Soc. Nephrol. 2007)
    101. Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site. (PubMed id 15975933)1 Dublet B....Witko-Sarsat V. (J. Biol. Chem. 2005)
    102. Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. (PubMed id 15527767)1 Grimsby S....Souchelnytskyi S. (FEBS Lett. 2004)
    103. Wegener's granulomatosis--autoimmunity to neutrophil proteinase 3. (PubMed id 12894870)1 Watorek E....Klinger M. (Arch. Immunol. Ther. Exp. (Warsz.) 2003)
    104. Functional dissociation between proforms and mature forms of proteinase 3, azurocidin, and granzyme B in regulation of granulopoiesis. (PubMed id 12135665)1 SkAPld S....Olofsson T. (Exp. Hematol. 2002)
    105. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    106. Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). (PubMed id 12189154)1 Benarafa C....Remold-O'Donnell E. (J. Biol. Chem. 2002)
    107. Human proteinase 3 can inhibits LPS-mediated TNF-alpha production through CD14 degradation: lack of influence of antineutrophil cytoplasmic antibodies. (PubMed id 12067299)1 Yard B.A....van der Woude F.J. (Clin. Exp. Immunol. 2002)
    108. Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. (PubMed id 11714826)1 Sugawara S....Takada H. (J. Immunol. 2001)
    109. Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry. (PubMed id 10978167)1 Loew D....Lanza F. (Biochemistry 2000)
    110. Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family. (PubMed id 10512713)1 Abts H.F....Ruzicka T. (J. Mol. Biol. 1999)
    111. Inhibitory properties of recombinant human monocyte/neutrophil elastase inhibitor. (PubMed id 7654387)1 Sugimori T....Remold-O'Donnell E. (Am. J. Respir. Cell Mol. Biol. 1995)
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    376. [A case of MA1nchausen syndrome with recurrent bacteremia and PR3-ANCA positivity]. (PubMed id 17447478)9 Hashimoto A....Endo H. (Kansenshogaku Zasshi 2007)
    377. Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients. (PubMed id 17030385)9 Komine K....Sugawara S. (Mol. Immunol. 2007)
    378. Analysis of individual azurocidin N-glycosylation sites in regard to its secretion by insect cells, susceptibility to proteolysis and antibacterial activity. (PubMed id 17653303)9 Indyk K....Olczak M. (Acta Biochim. Pol. 2007)
    379. Current knowledge on cellular interactions in the WG-granuloma. (PubMed id 17428367)9 Lamprecht P. and Gross W.L. (Clin. Exp. Rheumatol. 2007)
    380. Clinical and pathological features of renal involvement in propylthiouracil-associated ANCA-positive vasculitis. (PubMed id 17472842)9 Yu F....Wang H.Y. (Am. J. Kidney Dis. 2007)
    381. Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA). (PubMed id 17614969)9 Talor M.V....Burek C.L. (Clin. Exp. Immunol. 2007)
    382. Chimeric antibodies to proteinase 3 of IgG1 and IgG3 subclasses induce different magnitudes of functional responses in neutrophils. (PubMed id 17204568)9 Colman R....Williams J.M. (Ann. Rheum. Dis. 2007)
    383. Immunotherapeutic strategies in chronic myeloid leukemia. (PubMed id 20425356)9 Clark R.E. (Curr Hematol Malig Rep 2007)
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    386. ANCA-associated vasculitis: diagnostic and therapeutic strategy. (PubMed id 17460438)9 Ozaki S. (Allergol Int 2007)
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    388. Severe dysphagia in lower cranial nerve involvement as the initial symptom of Wegener's granulomatosis. (PubMed id 17658554)9 Armani M....Tavolato B. (J. Neurol. Sci. 2007)
    389. Latex immunoagglutination assay for a vasculitis marker in a microfluidic device using static light scattering detection. (PubMed id 17141495)9 Lucas L.J....Yoon J.Y. (amp 2007)
    390. Human leukocyte elastase hydrolysis of peptides derived from human elastin exon 24. (PubMed id 16945464)9 Lombard C....Saulnier J. (Biochimie 2006)
    391. Role of polymorphonuclear leukocyte-derived serine proteinases in defense against Actinobacillus actinomycetemcomitans. (PubMed id 16926422)9 de Haar S.F....Beertsen W. (Infect. Immun. 2006)
    392. Wegener's granulomatosis of the penis: genital presentation of systemic disease. (PubMed id 16707888)9 Al Rajabi W....Calzavara-Pinton P. (Dermatology (Basel) 2006)
    393. Alpha-melanocyte-stimulating hormone down-regulates CXC receptors through activation of neutrophil elastase. (PubMed id 16479540)9 Manna S.K....Sreenivasan Y. (Eur. J. Immunol. 2006)
    394. Identification of novel functional sequence variants in the gene for peptidase inhibitor 3. (PubMed id 16719916)9 Chowdhury M.A....Tromp G. (BMC Med. Genet. 2006)
    395. [A case of squamous cell carcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody]. (PubMed id 17228809)9 Morisako T....Matsuoka T. (Nihon Kokyuki Gakkai Zasshi 2006)
    396. Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer. (PubMed id 17143367)9 Al-Shukaili A....Al-Moundhri M.S. (Saudi Med J 2006)
    397. Targeting serine proteases in asthma. (PubMed id 16611150)9 Guay C....Tremblay G.M. (Curr Top Med Chem 2006)
    398. Neutrophil granule proteins as targets of leukemia-specific immune responses. (PubMed id 16319682)9 Barrett J. and Rezvani K. (Curr. Opin. Hematol. 2006)
    399. Production and applications of recombinant proteinase 3, Wegener's autoantigen: problems and perspectives. (PubMed id 16995336)9 Jenne D.E. and Kuhl A. (Clin. Nephrol. 2006)
    400. TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations. (PubMed id 17699331)9 Huugen D....Heeringa P. (Clin J Am Soc Nephrol 2006)
    401. Human antimicrobial peptide LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study. (PubMed id 17181861)9 Ciornei C.D....Bodelsson M. (BMC Cardiovasc Disord 2006)
    402. Cancer vaccines for patients with acute myeloid leukemia--definition of leukemia-associated antigens and current clinical protocols targeting these antigens. (PubMed id 17145602)9 Greiner J....Schmitt M. (Haematologica 2006)
    403. A novel MHC-associated proteinase 3 peptide isolated from primary chronic myeloid leukaemia cells further supports the significance of this antigen for the immunotherapy of myeloid leukaemias. (PubMed id 16628186)9 Knights A.J....Pawelec G. (Leukemia 2006)
    404. Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall. (PubMed id 15485998)9 Hermann J....Graninger W. (Ann. Rheum. Dis. 2005)
    405. A novel capture-ELISA for detection of anti-neutrophil cytoplasmic antibodies (ANCA) based on c-myc peptide recognition in carboxy-terminally tagged recombinant neutrophil serine proteases. (PubMed id 16242707)9 Lee A.S....Specks U. (J. Immunol. Methods 2005)
    406. The influence of different cultivating conditions on polymorphonuclear leukocyte apoptotic process in vitro, II: ultrastructural characteristics of PMN populations incubated with proteinase 3 anti-neutrophil autoantibodies. (PubMed id 15931779)9 Guejes L....Shoenfeld Y. (Ultrastruct Pathol 2005)
    407. Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase. (PubMed id 15653931)9 Oltmanns U....Chung K.F. (Am. J. Respir. Cell Mol. Biol. 2005)
    408. Neutrophil serine proteases: potential key regulators of cell signalling during inflammation. (PubMed id 15788001)9 Wiedow O. and Meyer-Hoffert U. (J. Intern. Med. 2005)
    409. Glycosaminoglycan: a candidate to stimulate the repair of chronic wounds. (PubMed id 16113778)9 Peplow P.V. (Thromb. Haemost. 2005)
    410. In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins. (PubMed id 15958635)9 Fujiwara H....Barrett A.J. (Clin. Cancer Res. 2005)
    411. New insights that link microbes with the generation of antineutrophil cytoplasmic autoantibodies: the theory of autoantigen complementarity. (PubMed id 15821413)9 Preston G.A....Falk R.J. (Curr. Opin. Nephrol. Hypertens. 2005)
    412. Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase. (PubMed id 16300411)9 Guyot N....Moreau T. (Biochemistry 2005)
    413. Dendritic cells generated from acute myeloid leukemia (AML) blasts maintain the expression of immunogenic leukemia associated antigens. (PubMed id 15627212)9 Li L....Schmitt M. (Cancer Immunol. Immunother. 2005)
    414. Antigen-specific cellular immunotherapy of leukemia. (PubMed id 16121214)9 Van Driessche A....Van Tendeloo V.F. (Leukemia 2005)
    415. Neutrophil activation in anti-proteinase 3-positive vasculitis--a prospective study. (PubMed id 16316421)9 Wikman A....Jacobson S.H. (Scand. J. Immunol. 2005)
    416. Activation, apoptosis, and clearance of neutrophils in Wegener's granulomatosis. (PubMed id 16126939)9 van Rossum A.P....Kallenberg C.G. (Ann. N. Y. Acad. Sci. 2005)
    417. Analysis of a biomarker for Wegener's granulomatosis. (PubMed id 16026591)9 Cooley P....Taylor J.F. (Int. J. Immunogenet. 2005)
    418. Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation. (PubMed id 16006536)9 Hattar K....Sibelius U. (J. Leukoc. Biol. 2005)
    419. Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. (PubMed id 15996183)9 Lamprecht P. (Clin. Exp. Immunol. 2005)
    420. Proteinase 3 hydrolysis of peptides derived from human elastin exon 24. (PubMed id 15895295)9 Lombard C....Saulnier J. (Amino Acids 2005)
    421. Autoantibody formation in patients with rheumatoid arthritis treated with anti-TNF alpha. (PubMed id 15297281)9 Eriksson C....RantapAoAo-Dahlqvist S. (Ann. Rheum. Dis. 2005)
    422. Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases. (PubMed id 15728180)9 Ryu O.H....Hart T.C. (J. Biol. Chem. 2005)
    423. Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain. (PubMed id 15078883)9 Hirche T.O....Belaaouaj A. (J. Biol. Chem. 2004)
    424. Immune complex deposits in ANCA-associated crescentic glomerulonephritis: a study of 126 cases. (PubMed id 15149327)9 Haas M. and Eustace J.A. (Kidney Int. 2004)
    425. Proteolytic conversion of STAT3alpha to STAT3gamma in human neutrophils: role of granule-derived serine proteases. (PubMed id 15145953)9 Kato T....Kitagawa S. (J. Biol. Chem. 2004)
    426. Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study. (PubMed id 14585921)9 Csernok E....Gross W.L. (Rheumatology (Oxford) 2004)
    427. Antineutrophil cytoplasmic antibodies (ANCA): diagnostic utility and potential role in the pathogenesis of vasculitis. (PubMed id 15588565)9 Malenica B....Kozmar A. (Acta Dermatovenerol Croat 2004)
    428. Genetic impact of pathogenesis and prognosis of ANCA-associated vasculitides. (PubMed id 15675141)9 Borgmann S. and Haubitz M. (Clin. Exp. Rheumatol. 2004)
    429. Clonogenicity, gene expression and phenotype during neutrophil versus erythroid differentiation of cytokine-stimulated CD34+ human marrow cells in vitro. (PubMed id 15521924)9 Edvardsson L....Olofsson T. (Br. J. Haematol. 2004)
    430. Shunt nephritis with positive titers for ANCA specific for proteinase 3. (PubMed id 15112193)9 Iwata Y....Yoshida K. (Am. J. Kidney Dis. 2004)
    431. Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase. (PubMed id 15070688)9 Fujiwara H....Barrett A.J. (Blood 2004)
    432. [Clinical characteristics of propylthiouracil (PTU) induced antineutrophil cytoplasmic antibodies positive cases; analysis of a case of PTU-induced ANCA positive patients with hyperthyroidism]. (PubMed id 15730621)9 Li M.T....Tang F.L. (Zhonghua Yi Xue Za Zhi 2004)
    433. Aneurysmal subarachnoid hemorrhage in a patient with Wegener's granulomatosis. (PubMed id 15480908)9 Takei H....Katayama Y. (Clin. Exp. Nephrol. 2004)
    434. Monocyte activation by circulating fibronectin fragments in HIV-1-infected patients. (PubMed id 15265957)9 Trial J....Rossen R.D. (J. Immunol. 2004)
    435. Loss-of-function mutations in cathepsin C in two families with Papillon-Lefevre syndrome are associated with deficiency of serine proteinases in PMNs. (PubMed id 15108292)9 de Haar S.F....Beertsen W. (Hum. Mutat. 2004)
    436. Selective killing of B-cell hybridomas targeting proteinase 3, Wegener's autoantigen. (PubMed id 15147566)9 Reiners K.S....Von Strandmann E.P. (Immunology 2004)
    437. Epitope mapping of anti-PR3 antibodies using chimeric human/mouse PR3 recombinant proteins. (PubMed id 14678279)9 Selga D....Hellmark T. (Clin. Exp. Immunol. 2004)
    438. Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo. (PubMed id 15150076)9 Pfister H....Jenne D.E. (Blood 2004)
    439. Monoclonal LYM-1 antibody-dependent cytolysis by human neutrophils exposed to GM-CSF: auto-regulation of target cell attack by cathepsin G. (PubMed id 14525961)9 Ottonello L....Dallegri F. (J. Leukoc. Biol. 2004)
    440. Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre-elafin (trappin-2) expressed in Pichia pastoris. (PubMed id 15182352)9 Zani M.L....Moreau T. (Eur. J. Biochem. 2004)
    441. Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report. (PubMed id 15459817)9 Kanazawa M....Gejyo F. (Clin. Rheumatol. 2004)
    442. Crosstalk between inflammation and thrombosis. (PubMed id 15063484)9 Esmon C.T. (Maturitas 2004)
    443. Positive classic antineutrophil cytoplasmic antibody (C-ANCA) titer at switch to azathioprine therapy associated with relapse in proteinase 3-related vasculitis. (PubMed id 15077271)9 Slot M.C....Stegeman C.A. (Arthritis Rheum. 2004)
    444. Use of immunofluorescence and confocal laser scanning microscopy in identifying rare cases of anti-neutrophil cytoplasmic antibodies (ANCA) showing dual specificities to myeloperoxidase and proteinase3. (PubMed id 15617388)9 Badakere S.S....Pawar A.R. (J Fluoresc 2004)
    445. Rapid inactivation of alpha-1-proteinase inhibitor by neutrophil specific leukolysin/membrane-type matrix metalloproteinase 6. (PubMed id 15149845)9 Nie J. and Pei D. (Exp. Cell Res. 2004)
    446. B cell epitope specificity in ANCA-associated vasculitis: does it matter? (PubMed id 15320893)9 van der Geld Y.M....Kallenberg C.G. (Clin. Exp. Immunol. 2004)
    447. Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina. (PubMed id 12759353)9 SA...Borregaard N. (J. Biol. Chem. 2003)
    448. Diversity of PR3-ANCA epitope specificity in Wegener's granulomatosis. Analysis using the biosensor technology. (PubMed id 15031633)9 Rarok A.A....Kallenberg C.G. (J. Clin. Immunol. 2003)
    449. Plasma neutrophil lipocalin, elastase-alpha1-antitrypsin complex and neutrophil protease 4 in preterm infants with respiratory distress syndrome. (PubMed id 12751689)9 Sveger T....Laurin S. (Scand. J. Clin. Lab. Invest. 2003)
    450. Antineutrophil cytoplasmic antibodies (ANCA) and small vessel vasculitis. (PubMed id 12945480)9 Mareen P....Dierick J. (Acta Clin Belg 2003)
    451. Audit of the clinical usefulness of a rapid qualitative ELISA screen for antimyeloperoxidase and antiproteinase 3 antibodies in the assessment of patients with suspected vasculitis. (PubMed id 14514783)9 Aslam A....Misbah S.A. (J. Clin. Pathol. 2003)
    452. Frequency of antineutrophil cytoplasmic antibody in Graves' disease patients treated with methimazole. (PubMed id 12727967)9 GumA M....OlivAc A. (J. Clin. Endocrinol. Metab. 2003)
    453. Sinonasal osteocartilaginous necrosis in cocaine abusers: experience in 25 patients. (PubMed id 12693654)9 Trimarchi M....Specks U. (Am J Rhinol 2003)
    454. Monitoring proteinase 3 antineutrophil cytoplasmic antibodies for detection of relapses in small vessel vasculitis. (PubMed id 12965902)9 Segelmark M....Jennette J.C. (Clin. Diagn. Lab. Immunol. 2003)
    455. [Prevalence and specificity of antineutrophil cytoplasmic antibodies (ANCA) in connective tissue diseases]. (PubMed id 12879764)9 Puszczewicz M....Tuchocka A. (Pol. Arch. Med. Wewn. 2003)
    456. Bactericidal/permeability-increasing protein and cathepsin G are the major antigenic targets of antineutrophil cytoplasmic autoantibodies in systemic sclerosis. (PubMed id 12784398)9 Khanna D....Misra R. (J. Rheumatol. 2003)
    457. Expression of myeloperoxidase (MPO) by neutrophils is necessary for their activation by anti-neutrophil cytoplasm autoantibodies (ANCA) against MPO. (PubMed id 12773517)9 Reumaux D....Roos D. (J. Leukoc. Biol. 2003)
    458. Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2. (PubMed id 12759451)9 Uehara A....Sugawara S. (J. Immunol. 2003)
    459. Neutrophil-activating potential of antineutrophil cytoplasm autoantibodies. (PubMed id 12832437)9 Rarok A.A....Kallenberg C.G. (J. Leukoc. Biol. 2003)
    460. Membrane proteinase 3 expression on resting neutrophils as a pathogenic factor in PR3-ANCA-associated vasculitis. (PubMed id 14740429)9 van Rossum A.P....Kallenberg C.G. (Clin. Exp. Rheumatol. 2003)
    461. Coagulation and inflammation. (PubMed id 12831462)9 Esmon C.T. (J. Endotoxin Res. 2003)
    462. Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis. (PubMed id 12393522)9 El Ouriaghli F....Barrett A.J. (Blood 2003)
    463. Natural T cell immunity against cancer. (PubMed id 14555498)9 Nagorsen D....Keilholz U. (Clin. Cancer Res. 2003)
    464. Pulmonary-renal vasculitic disorders: differential diagnosis and management. (PubMed id 12628041)9 Jara L.J....Calleja M.C. (Curr Rheumatol Rep 2003)
    465. Effects of carboxy-terminal modifications of proteinase 3 (PR3) on the recognition by PR3-ANCA. (PubMed id 12631144)9 Capizzi S.A....Specks U. (Kidney Int. 2003)
    466. Does infection play a role in the pathogenesis of pulmonary vasculitis? (PubMed id 12652450)9 Capizzi S.A. and Specks U. (Semin Respir Infect 2003)
    467. Increased expression of the secretory leukocyte proteinase inhibitor in Wegener's granulomatosis. (PubMed id 12519404)9 Ohlsson S....Wieslander J. (Clin. Exp. Immunol. 2003)
    468. Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells. (PubMed id 12591275)9 LAcvesque J.P....Simmons P.J. (Exp. Hematol. 2003)
    469. Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses. (PubMed id 12763937)9 Amrolia P.J....Brenner M.K. (Blood 2003)
    470. Proteolysis of surfactant protein D by cystic fibrosis relevant proteases. (PubMed id 12953146)9 von Bredow C....Griese M. (Lung 2003)
    471. Borrelia burgdorferi are susceptible to killing by a variety of human polymorphonuclear leukocyte components. (PubMed id 11920297)9 Lusitani D....Montgomery R.R. (J. Infect. Dis. 2002)
    472. Interaction of antibodies to proteinase 3 (classic anti-neutrophil cytoplasmic antibody) with human renal tubular epithelial cells: impact on signaling events and inflammatory mediator generation. (PubMed id 11884479)9 Hattar K....Sibelius U. (J. Immunol. 2002)
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    474. Novel genetic association of Wegener's granulomatosis with the interleukin 10 gene. (PubMed id 11838849)9 Zhou Y....Lefvert A.K. (J. Rheumatol. 2002)
    475. Kinetics of thrombomodulin release and endothelial cell injury by neutrophil-derived proteases and oxygen radicals. (PubMed id 12423310)9 Boehme M.W....Stremmel W. (Immunology 2002)
    476. ANCA-positive glomerulonephritis and IgA nephropathy in a patient on propylthiouracil. (PubMed id 11956877)9 Winters M.J....Lirenman D.S. (Pediatr. Nephrol. 2002)
    477. Measurement of free and membrane-bound cathepsin G in human neutrophils using new sensitive fluorogenic substrates. (PubMed id 12088507)9 Attucci S....Gauthier F. (Biochem. J. 2002)
    478. Release and degradation of angiotensin I and angiotensin II from angiotensinogen by neutrophil serine proteinases. (PubMed id 11747312)9 Ramaha A. and Patston P.A. (Arch. Biochem. Biophys. 2002)
    479. Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major autoantigens in hepatitis C virus (HCV) infection. (PubMed id 11985526)9 Wu Y.Y....Tsay G.J. (Clin. Exp. Immunol. 2002)
    480. Anti-neutrophil cytoplasmic antibody (ANCA) levels directed against proteinase-3 and myeloperoxidase are helpful in predicting disease relapse in ANCA-associated small-vessel vasculitis. (PubMed id 12454214)9 Stegeman C.A. (Nephrol. Dial. Transplant. 2002)
    481. Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. (PubMed id 11784720)9 Patzke H. and Tsai L.H. (J. Biol. Chem. 2002)
    482. -463 G/A myeloperoxidase promoter polymorphism is associated with clinical manifestations and the course of disease in MPO-ANCA-associated vasculitis. (PubMed id 12027420)9 Reynolds W.F....Tervaert J.W. (Clin. Immunol. 2002)
    483. Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production. (PubMed id 12223522)9 Nemoto E....Shimauchi H. (J. Leukoc. Biol. 2002)
    484. Are autoantibodies present in patients with subacute and chronic urticaria? (PubMed id 11436965)9 Ryhal B....Gershwin M.E. (amp 2001)
    485. Antineutrophil cytoplasmic autoantibody specific for proteinase 3 in a patient with shunt nephritis induced by Gemella morbillorum. (PubMed id 11325703)9 Nagashima T....Minota S. (Am. J. Kidney Dis. 2001)
    486. Anti-MPO-ANCA-positive microscopic polyangiitis following subacute bacterial endocarditis. (PubMed id 11771532)9 Hellmich B....Schatz H. (Clin. Rheumatol. 2001)
    487. More than destructive: neutrophil-derived serine proteases in cytokine bioactivity control. (PubMed id 11272269)9 Bank U. and Ansorge S. (J. Leukoc. Biol. 2001)
    488. Comparison of anti-PR3 capture and anti-PR3 direct ELISA for detection of antineutrophil cytoplasmic antibodies (ANCA) in long-term clinical follow-up of PR3-ANCA-associated vasculitis patients. (PubMed id 11680659)9 Arranz O....Darnell A. (Clin. Nephrol. 2001)
    489. Glomerular lesions in patients with Churg-Strauss syndrome and the anti-myeloperoxidase antibody. (PubMed id 11434353)9 Kikuchi Y....Miura S. (Clin. Nephrol. 2001)
    490. 1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases. (PubMed id 11361013)9 Groutas W.C....Vu N.T. (Arch. Biochem. Biophys. 2001)
    491. Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation. (PubMed id 11445734)9 Esmon C.T. (Crit. Care Med. 2001)
    492. Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin. (PubMed id 11415941)9 Rooney C.P....O'Neill S.J. (Am. J. Respir. Cell Mol. Biol. 2001)
    493. Antineutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus: prevalence, antigen specificity, and clinical associations. (PubMed id 11518040)9 Manolova I....Halacheva K. (Rheumatol. Int. 2001)
    494. Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis. (PubMed id 11200073)9 Hattar K....Grimminger F. (J. Leukoc. Biol. 2001)
    495. Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold. (PubMed id 11408173)9 Groutas W.C....Chan H.K. (amp 2001)
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    498. Indirect immunofluorescence (IIF) of normal washed peripheral blood cells to demonstrate antineutrophil cytoplasmic antibodies (ANCA). (PubMed id 11064672)9 Paspaliaris B....Savige J. (J. Clin. Pathol. 2000)
    499. Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK) (PubMed id 10824890)9 Lindgren S....Wieslander J. (J. Gastroenterol. Hepatol. 2000)
    500. Antineutrophil cytoplasmic antibodies (ANCA) and systemic vasculitis: update of assays, immunopathogenesis, controversies, and report of a novel de novo ANCA-associated vasculitis after kidney transplantation. (PubMed id 10805352)9 Schultz D.R. and Diego J.M. (Semin. Arthritis Rheum. 2000)
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    502. Effect of DNase on the activity of neutrophil elastase, cathepsin G and proteinase 3 in the presence of DNA. (PubMed id 10812064)9 Duranton J....Bieth J.G. (FEBS Lett. 2000)
    503. Characterisation of autoantibodies to neutrophil granule constituents among patients with reactive arthritis, rheumatoid arthritis, and ulcerative colitis. (PubMed id 11053069)9 Locht H....Wiik A. (Ann. Rheum. Dis. 2000)
    504. Antiproteinase 3- and antimyeloperoxidase-associated vasculitis. (PubMed id 10844589)9 Franssen C.F....Tervaert J.W. (Kidney Int. 2000)
    505. Evaluation of antineutrophil cytoplasmic antibody seroconversion induced by minocycline, sulfasalazine, or penicillamine. (PubMed id 11083272)9 Choi H.K....Merkel P.A. (Arthritis Rheum. 2000)
    506. What you should know about PR3-ANCA. An introduction. (PubMed id 11094436)9 Wiik A. (Arthritis Res. 2000)
    507. Effect of the serine protease inhibitor N-tosyl-l-phenylalanine-chloromethyl ketone (TPCK) on MCF-7 mammary tumour cells growth and differentiation. (PubMed id 10772776)9 Horman S....Galand P. (Cell Biol. Int. 2000)
    508. Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study. (PubMed id 11014352)9 Boomsma M.M....Tervaert J.W. (Arthritis Rheum. 2000)
    509. Contribution of immunofluorescence to the identification and characterization of anti-neutrophil cytoplasmic autoantibodies. The role of different fixatives. (PubMed id 11138332)9 Radice A....Sinico R.A. (Clin. Exp. Rheumatol. 2000)
    510. Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis. (PubMed id 10766165)9 Johnson D.E....Rabinowich H. (Cancer Res. 2000)
    511. Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates. (PubMed id 10882012)9 Kuang R....Groutas W.C. (amp 2000)
    512. Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis. (PubMed id 10691933)9 Tse W.Y....Adu D. (Clin. Exp. Immunol. 2000)
    513. A case of relapse of C-ANCA-associated glomerulonephritis in post-transplant patients. (PubMed id 11092351)9 Oka K....Hori M. (Clin Transplant 2000)
    514. Parvovirus B19 infection associated with the production of anti-neutrophil cytoplasmic antibody (ANCA) and anticardiolipin antibody (aCL). (PubMed id 11035424)9 Chou T.N....Tsay G.J. (Lupus 2000)
    515. Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide. (PubMed id 10976518)9 He S....Groutas W.C. (amp 2000)
    516. How and why should we detect ANCA? (PubMed id 11072609)9 Segelmark M....Wieslander J. (Clin. Exp. Rheumatol. 2000)
    517. Activation of progelatinase B by membranes of human polymorphonuclear granulocytes. (PubMed id 10722050)9 Kolkenbrock H....Ulbrich N. (Biol. Chem. 2000)
    518. [Microscopic polyangiitis]. (PubMed id 10896971)9 Venetz J.P. and Rossert J. (Ann Med Interne (Paris) 2000)
    519. Restriction in V kappa gene use and antigen selection in anti-myeloperoxidase response in mice. (PubMed id 11034396)9 Jethwa H.S....Nachman P.H. (J. Immunol. 2000)
    520. A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia. (PubMed id 10363991)9 Molldrem J.J....Davis M.M. (Cancer Res. 1999)
    521. What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications. (PubMed id 10456261)9 Kallenberg C.G. and Tervaert J.W. (Curr. Opin. Nephrol. Hypertens. 1999)
    522. A latex slide agglutination test for rapid detection of antimyeloperoxidase antibody. (PubMed id 10674037)9 Ko K.H....Lawton J.W. (J. Clin. Pathol. 1999)
    523. Recombinant human Monocyte/Neutrophil elastase inhibitor protects rat lungs against injury from cystic fibrosis airway secretions. (PubMed id 9870919)9 Rees D.D....Remold-O'Donnell E. (Am. J. Respir. Cell Mol. Biol. 1999)
    524. Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis. (PubMed id 10469064)9 Locht H....KihlstrAPm E. (Clin. Exp. Immunol. 1999)
    525. In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis. (PubMed id 10464553)9 Muller Kobold A.C....Tervaert J.W. (Clin. Exp. Rheumatol. 1999)
    526. Eosinophilia in Wegener's granulomatosis. (PubMed id 10559120)9 Potter M.B....Finger D.R. (Chest 1999)
    527. Wegener's granulomatosis associated with renal cell carcinoma. (PubMed id 10211890)9 Tatsis E....Gross W.L. (Arthritis Rheum. 1999)
    528. No association between neutrophil FcgammaRIIa allelic polymorphism and anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis. (PubMed id 10403936)9 Tse W.Y....Adu D. (Clin. Exp. Immunol. 1999)
    529. Seroprevalence and disease association of antineutrophil cytoplasmic autoantibodies and antigens in HIV infection. (PubMed id 10219637)9 Cornely O.A....Schrappe M. (Infection 1999)
    530. The role of alpha1 -antitrypsin Deficiency in the Pathogenesis of Antineutrophil Cytoplasmic Antibodies Associated Systemic Necrotizing Vasculitides. (PubMed id 18212413)9 Alzouki A.N. (Saudi J Kidney Dis Transpl 1999)
    531. [The diagnostic significance of antineutrophil cytoplasmic antibodies in ulcerative colitis]. (PubMed id 11798679)9 Liu X....Liu N. (Zhonghua Nei Ke Za Zhi 1999)
    532. The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules. (PubMed id 10614782)9 Cowland J.B. and Borregaard N. (J. Leukoc. Biol. 1999)
    533. The prevalence and clinical significance of alpha 1-antitrypsin deficiency (PiZ) and ANCA specificities (proteinase 3, BPI) in patients with ulcerative colitis. (PubMed id 10579117)9 Elzouki A.N....Lindgren S. (Inflamm. Bowel Dis. 1999)
    534. Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis. (PubMed id 10025935)9 Choi H.K....Niles J.L. (Arthritis Rheum. 1999)
    535. Anti-PR-3 antibodies induce endothelial IL-8 release. (PubMed id 10583443)9 Mayet W....Neurath M. (Eur. J. Clin. Invest. 1999)
    536. Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response. (PubMed id 9463400)9 Sibelius U....Grimminger F. (J. Exp. Med. 1998)
    537. Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. (PubMed id 9864022)9 Hiemstra P.S....Stolk J. (Eur. Respir. J. 1998)
    538. Cationic proteins of neutrophil azurophilic granules: protein-protein interaction and blockade of NADPH oxidase activation. (PubMed id 9500517)9 Tal T....Irit A. (J. Leukoc. Biol. 1998)
    539. Endothelial derived vasoactive factors and leukocyte derived inflammatory mediators in subjects with asymptomatic atherosclerosis. (PubMed id 9855370)9 Anwaar I....LindgAorde F. (Angiology 1998)
    540. The presence of cytoplasmic antineutrophil cytoplasmic antibodies (C-ANCA) in the course of subacute bacterial endocarditis with glomerular involvement, coincidence or association? (PubMed id 9491280)9 Subra J.F....Chevailler A. (Clin. Nephrol. 1998)
    541. SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis. (PubMed id 9727750)9 Kuijpers A.L....Schalkwijk J. (Clin. Genet. 1998)
    542. Clinical spectrum associated with positive ANCA titres in 94 consecutive patients: is there a relation with PR-3 negative c-ANCA and hypergammaglobulinaemia? (PubMed id 9640128)9 Blockmans D....Bobbaers H. (Ann. Rheum. Dis. 1998)
    543. The appropriate use of antineutrophil cytoplasmic antibody (ANCA) testing in rheumatic diseases. (PubMed id 9588276)9 Teo D.L. (Ann. Acad. Med. Singap. 1998)
    544. Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene. (PubMed id 9630619)9 Zeng W.... Remold-O'Donnell E. (Gene 1998)
    545. Prevalence and clinical significance of anti-lactoferrin autoantibodies in inflammatory bowel diseases and primary sclerosing cholangitis. (PubMed id 9781375)9 Roozendaal C....Kallenberg C.G. (Adv. Exp. Med. Biol. 1998)
    546. Fibroblast and epidermal growth factor receptor expression in Xenopus oocytes displays distinct calcium oscillatory patterns. (PubMed id 9739176)9 Browaeys-Poly E....Vilain J.P. (Biochim. Biophys. Acta 1998)
    547. Antineutrophil cytoplasmic autoantibodies (ANCA) and their target antigens in Chinese patients with lupus nephritis. (PubMed id 9829484)9 Zhao M.H....Wang H.Y. (Nephrol. Dial. Transplant. 1998)
    548. Escherichia coli and Proteus mirabilis inhibit the perinuclear but not the circulating antineutrophil cytoplasmic antibody reaction. (PubMed id 9648994)9 Yang P....JAornerot G. (Scand. J. Gastroenterol. 1998)
    549. Identification, origins and the diurnal role of the principal serine protease inhibitors in human tear fluid. (PubMed id 9561826)9 Sathe S....Sack R.A. (Curr. Eye Res. 1998)
    550. Affinity chromatography of serine proteases on the triazine dye ligand Cibacron Blue F3G-A. (PubMed id 9832358)9 Koch C....Houen G. (J. Chromatogr. B Biomed. Sci. Appl. 1998)
    551. Truncation of Sp1 transcription factor by myeloblastin in undifferentiated HL60 cells. (PubMed id 9525470)9 Rao J....Studzinski G.P. (J. Cell. Physiol. 1998)
    552. Antineutrophil cytoplasmic autoantibodies (ANCA) in children with cystic fibrosis. (PubMed id 9650098)9 SedivA! A....Dunn A.C. (J. Autoimmun. 1998)
    553. Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold. (PubMed id 9125494)9 Groutas W.C....Prakash O. (Biochemistry 1997)
    554. Anti-neutrophil cytoplasmic antibody (ANCA) in malaria is directed against cathepsin G. (PubMed id 9353147)9 Yahya T.M....Bayoumi R. (Clin. Exp. Immunol. 1997)
    555. Structural analysis of human antibodies to proteinase 3 from patients with Wegener granulomatosis. (PubMed id 9218586)9 Sibilia J....Mariette X. (J. Immunol. 1997)
    556. Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors. (PubMed id 9294107)9 Ralston D.R....Wewers M.D. (J. Clin. Invest. 1997)
    557. Laboratory findings in the vasculitides. (PubMed id 9220083)9 Kallenberg C.G. (Baillieres Clin Rheumatol 1997)
    558. HLA genes in ANCA-associated vasculitides. (PubMed id 9493788)9 Griffith M.E. and Pusey C.D. (Exp. Clin. Immunogenet. 1997)
    559. Alpha-1-antitrypsin phenotyping in ANCA-associated diseases: one of several arguments for protease/antiprotease imbalance in systemic vasculitis. (PubMed id 9493789)9 Esnault V.L....SesboA1Ac R. (Exp. Clin. Immunogenet. 1997)
    560. Incidence and studies on antigenic specificities of antineutrophil-cytoplasmic autoantibodies (ANCA) in poststreptococcal glomerulonephritis. (PubMed id 9021233)9 Ardiles L.G....Mezzano S.A. (Clin. Nephrol. 1997)
    561. Induction of apoptosis without differentiation by retinoic acid in PLB-985 cells requires the activation of both RAR and RXR. (PubMed id 9345016)9 Monczak Y....Miller W.H. (Blood 1997)
    562. Systemic necrotizing vasculitis. (PubMed id 9220078)9 Gross W.L. (Baillieres Clin Rheumatol 1997)
    563. An enzyme immunoassay for polymorphonuclear leucocyte-mediated fibrinogenolysis. (PubMed id 9061309)9 Bos R....Nieuwenhuizen W. (Eur. J. Clin. Invest. 1997)
    564. Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease. (PubMed id 9155585)9 Walmsley R.S....Lockwood C.M. (Gut 1997)
    565. Leukocyte activation in atherosclerosis: correlation with risk factors. (PubMed id 9180248)9 Elneihoum A.M....Ohlsson K. (Atherosclerosis 1997)
    566. Extremely low levels of epidermal skin-derived antileucoproteinase/elafin in a patient with impetigo herpetiformis. (PubMed id 9274639)9 Kuijpers A.L....de Jong E.M. (Br. J. Dermatol. 1997)
    567. Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units. (PubMed id 9326217)9 Molldrem J.J....Barrett A.J. (Blood 1997)
    568. Purification of Wegener's granulomatosis autoantigen, proteinase 3, from neutrophils by Triton X-114 extraction of azurophilic granules. (PubMed id 9367512)9 Heegaard N.H....Klattschou D. (Anal. Biochem. 1997)
    569. Naturally processed tissue- and differentiation stage-specific autologous peptides bound by HLA class I and II molecules of chronic myeloid leukemia blasts. (PubMed id 9389712)9 Papadopoulos K.P....Harris P.E. (Blood 1997)
    570. Detection of anti-neutrophil cytoplasmic antibodies after acute Plasmodium falciparum malaria. (PubMed id 8770517)9 Wenisch C....Rumpold H. (Clin. Diagn. Lab. Immunol. 1996)
    571. Expression of the human autoantigen of Wegener's granulomatosis (PR3) in a baculovirus expression system. (PubMed id 8604978)9 Szymkowiak C.H....Gross W.L. (Biochem. Biophys. Res. Commun. 1996)
    572. Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation. (PubMed id 8879231)9 Grimminger F....Sibelius U. (J. Exp. Med. 1996)
    573. Autoantibodies and target antigens in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. (PubMed id 8893375)9 Savige J.A....Buchanan R.R. (Rheumatol. Int. 1996)
    574. Immunologic markers for differentiation of autoimmune responses. (PubMed id 8934922)9 Williams R.C. (Adv. Dent. Res. 1996)
    575. The diagnostic and prognostic significance of ANCA. (PubMed id 8903094)9 Lesavre P. (Ren Fail 1996)
    576. Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia. (PubMed id 8823304)9 Pfundt R....Schalkwijk J. (J. Clin. Invest. 1996)
    577. Human proteinase-3 expression is regulated by PU.1 in conjunction with a cytidine-rich element. (PubMed id 8943304)9 Sturrock A....Hoidal J.R. (J. Biol. Chem. 1996)
    578. Respiratory failure in ANCA-associated vasculitis. (PubMed id 8697833)9 ter Maaten J.C....Hoorntje S.J. (Chest 1996)
    579. Azurocidin is a novel antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in systemic vasculitis. (PubMed id 8608637)9 Zhao M.H. and Lockwood C.M. (Clin. Exp. Immunol. 1996)
    580. [Antineutrophil cytoplasmic antibodies and nonspecific ulcerative colitis]. (PubMed id 9110485)9 Rojas G....Mezzano S. (Rev Med Chil 1996)
    581. Expression of SKALP/elafin during wound healing in human skin. (PubMed id 8844125)9 van Bergen B.H....Schalkwijk J. (Arch. Dermatol. Res. 1996)
    582. Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells. (PubMed id 8839835)9 Molldrem J....Barrett A.J. (Blood 1996)
    583. Monoclonal antibody WGM1 directed against proteinase 3: an immunohistochemical marker for naphthol ASD chloroacetate. (PubMed id 8876637)9 Braun M.G....Feller A.C. (Hematol Oncol 1996)
    584. Anti-neutrophil cytoplasmic antibodies in patients with chromomycosis. (PubMed id 8913648)9 Galperin C....Gershwin M.E. (Clin. Exp. Rheumatol. 1996)
    585. [ANCA-associated forms of vasculitis]. (PubMed id 9065053)9 Helmchen U....Prall F. (Verh Dtsch Ges Pathol 1996)
    586. Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus. (PubMed id 8670594)9 Spronk P.E....Kallenberg C.G. (Br. J. Rheumatol. 1996)
    587. Pathogenic role of anti-endothelial cell antibodies in vasculitis. An idiotypic experimental model. (PubMed id 8648146)9 Damianovich M....Shoenfeld Y. (J. Immunol. 1996)
    588. Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases. (PubMed id 8841320)9 Elneihoum A.M....Ohlsson K. ( a journal of cerebral circulation 1996)
    589. Antibodies to proteinase 3 mediate expression of vascular cell adhesion molecule-1 (VCAM-1). (PubMed id 8565309)9 Mayet W.J....Meyer zum BA1schenfelde K.H. (Clin. Exp. Immunol. 1996)
    590. Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis. (PubMed id 7847352)9 Mrowka C....Thoenes G.H. (Am. J. Kidney Dis. 1995)
    591. Anti-neutrophil cytoplasmic antibodies in chronic inflammatory bowel disease. Prevalence and diagnostic role. (PubMed id 7481534)9 Hertervig E....Nilsson A. (Scand. J. Gastroenterol. 1995)
    592. Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration. (PubMed id 7554378)9 Blank M....Shoenfeld Y. (Clin. Exp. Immunol. 1995)
    593. Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus. (PubMed id 7534707)9 Wong S.N....Dillon M.J. (Eur. J. Pediatr. 1995)
    594. Antineutrophil cytoplasmic antibodies: major autoantigens, pathophysiology, and disease associations. (PubMed id 8650585)9 Schultz D.R. and Tozman E.C. (Semin. Arthritis Rheum. 1995)
    595. Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study. (PubMed id 7796046)9 Groutas W.C....Kim E.H. (amp 1995)
    596. Clinical correlates and substrate specificities of antibodies exhibiting neutrophil nuclear reactivity--a methodological study. (PubMed id 7499888)9 Bang la Cour B....Baslund B. (J. Immunol. Methods 1995)
    597. [Clinical and pathogenetic aspects of kidney damage associated with neutrophilic cytoplasm antibodies]. (PubMed id 7626983)9 Mukhin N.A....Makar'iants M.L. (Vestn. Akad. Med. Nauk SSSR 1995)
    598. Antineutrophil cytoplasmic antibodies in reactive arthritis. (PubMed id 8835566)9 Locht H....Skogh T. (J. Rheumatol. 1995)
    599. Effect of tumor necrosis factor-induced integrin activation on Fc gamma receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies. (PubMed id 7579414)9 Reumaux D....Verhoeven A.J. (Blood 1995)
    600. Levels of skin-derived antileukoproteinase (SKALP)/elafin in serum correlate with disease activity during treatment of severe psoriasis with cyclosporin A. (PubMed id 7829874)9 Alkemade H.A....Schalkwijk J. (J. Invest. Dermatol. 1995)
    601. Autoantibody profile in the sera of women with hyperprolactinemia. (PubMed id 7576002)9 Buskila D....Shoenfeld Y. (J. Autoimmun. 1995)
    602. Proteolysis of classic anti-neutrophil cytoplasmic autoantibodies (C-ANCA) by neutrophil proteinase 3. (PubMed id 7621597)9 Dolman K.M....Goldschmeding R. (Clin. Exp. Immunol. 1995)
    603. Primary SjAPgren's syndrome and primary biliary cirrhosis: differences and similarities in the autoantibody profile. (PubMed id 7586784)9 Tishler M....Shoenfeld Y. (Clin. Exp. Rheumatol. 1995)
    604. Characterization and chromosomal localization of ELANH2, the gene encoding human monocyte/neutrophil elastase inhibitor. (PubMed id 8530031)9 Evans E....Remold-O'Donnell E. (Genomics 1995)
    605. Multiple autoantibodies in patients with silicone breast implants. (PubMed id 7612152)9 Bar-Meir E....Blank M. (J. Autoimmun. 1995)
    606. Immunocytochemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells. (PubMed id 7873374)9 Dengler R....Emmerich B. (Br. J. Haematol. 1995)
    607. Oncoproteins and tumor progression in papillary thyroid carcinoma: presence of epidermal growth factor receptor, c-erbB-2 protein, estrogen receptor related protein, p21-ras protein, and proliferation indicators in relation to tumor recurrences and patient survival. (PubMed id 8635070)9 Akslen L.A. and Varhaug J.E. (Cancer 1995)
    608. 28-kDa mammalian heat shock protein, a novel substrate of a growth regulatory protease involved in differentiation of human leukemia cells. (PubMed id 7836350)9 Spector N.L....Luedke E. (J. Biol. Chem. 1995)
    609. [Effect of translocation t(15;17) on the gene expression regulation of myeloblastin during all trans retinoic acid induced myeloid differentiation in human leukemic cells]. (PubMed id 8564566)9 Ballerini P....Cayre Y.E. (C. R. Seances Soc. Biol. Fil. 1995)
    610. Studies of the release and turnover of a human neutrophil lipocalin. (PubMed id 8633182)9 Axelsson L....Ohlsson K. (Scand. J. Clin. Lab. Invest. 1995)
    611. Occurrence of antineutrophil cytoplasmic and antineutrophil (peri)nuclear antibodies in rheumatoid arthritis. (PubMed id 8596141)9 Bosch X....Urbano-MA!rquez A. (J. Rheumatol. 1995)
    612. In vitro processing of human tumor necrosis factor-alpha. (PubMed id 7559538)9 Robache-Gallea S....Roman-Roman S. (J. Biol. Chem. 1995)
    613. Immunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis. (PubMed id 7718417)9 Gross W.L. and Csernok E. (Curr Opin Rheumatol 1995)
    614. Detection of anti-neutrophil cytoplasmic antibodies by immunoprecipitation. (PubMed id 7554581)9 Lucena-Fernandes F....MAcnard H.A. (Clin Invest Med 1995)
    615. A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells. (PubMed id 7931077)9 Franzoso G....Siebenlist U.K. (J. Exp. Med. 1994)
    616. Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte-macrophage cell lineage. (PubMed id 8090034)9 Abrink M....Hellman L. (Leukemia 1994)
    617. Eosinophil peroxidase differs from neutrophil myeloperoxidase in its ability to bind antineutrophil cytoplasmic antibodies reactive with myeloperoxidase. (PubMed id 7920015)9 Sullivan S....Broide D.H. (Int. Arch. Allergy Immunol. 1994)
    618. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): a Fc gamma RII-dependent process. (PubMed id 7955533)9 Mulder A.H....Kallenberg C.G. (Clin. Exp. Immunol. 1994)
    619. Anti-neutrophil cytoplasmic antibodies (ANCA) in sera from patients with inflammatory bowel disease (IBD). Relation to disease pattern and disease activity. (PubMed id 7510606)9 Broekroelofs J....Kallenberg C.G. (Dig. Dis. Sci. 1994)
    620. SKALP/elafin is an inducible proteinase inhibitor in human epidermal keratinocytes. (PubMed id 7983189)9 Alkemade J.A....Schalkwijk J. (J. Cell. Sci. 1994)
    621. Antimicrobial proteins with homology to serine proteases. (PubMed id 7768154)9 Gabay J.E. (Ciba Found. Symp. 1994)
    622. Anti-neutrophil cytoplasmic antibodies: a new class of autoantibodies in glomerulonephritis, vasculitis and other inflammatory disorders. (PubMed id 7838242)9 Tervaert J.W....Kallenberg C.G. (Neth J Med 1994)
    623. Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3. (PubMed id 7925979)9 Padrines M....Baggiolini M. (FEBS Lett. 1994)
    624. Use of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient population. (PubMed id 7915885)9 Li P.K....Lai K.N. (Am. J. Nephrol. 1994)
    625. Alpha 1-antitrypsin phenotypes in patients with anti-neutrophil cytoplasmic antibody-positive vasculitis. (PubMed id 7874861)9 Lhotta K....KAPnig P. (Clin. Sci. 1994)
    626. Absence of antineutrophil cytoplasmic antibodies in giant cell arteritis. (PubMed id 8064728)9 Baranger T.A....Esnault V.L. (J. Rheumatol. 1994)
    627. Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma. (PubMed id 7965407)9 Alkemade H.A....Schalkwijk J. (J. Pathol. 1994)
    628. [Wegener's granulomatosis]. (PubMed id 7933591)9 Yoshida M. (Nippon Rinsho 1994)
    629. Elastase inhibitor elafin is a new type of proteinase inhibitor which has a transglutaminase-mediated anchoring sequence termed &quot;cementoin&quot;. (PubMed id 7914520)9 Nara K....Hirose S. (J. Biochem. 1994)
    630. Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides. (PubMed id 8296655)9 Csernok E....Gross W.L. (Adv. Exp. Med. Biol. 1993)
    631. Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement. (PubMed id 8352807)9 Groutas W.C....McClenahan J.J. (Biochem. Biophys. Res. Commun. 1993)
    632. Anti-neutrophil cytoplasmic antibodies in giant cell arteritis and polymyalgia rheumatica. (PubMed id 8296636)9 Cats H.A....Kallenberg C.G. (Adv. Exp. Med. Biol. 1993)
    633. Antineutrophil-cytoplasmic-autoantibodies in poststreptococcal nephritis. (PubMed id 8296654)9 Mezzano S....Caorsi I. (Adv. Exp. Med. Biol. 1993)
    634. Localization of the gene encoding proteinase-3 (the Wegener's granulomatosis autoantigen) to human chromosome band 19p13.3. (PubMed id 8508676)9 Sturrock A.B....Le Beau M.M. (Cytogenet. Cell Genet. 1993)
    635. Autoantibodies to neutrophil cytoplasmic enzymes in Felty's syndrome. (PubMed id 7689047)9 Coremans I.E....Breedveld F.C. (Clin. Exp. Rheumatol. 1993)
    636. Antineutrophil cytoplasmic antibodies in rheumatoid arthritis. Characterization and clinical correlations. (PubMed id 8343182)9 Mulder A.H....Kallenberg C.G. (Arthritis Rheum. 1993)
    637. ANCA in systemic vasculitides, collagen vascular diseases, rheumatic disorders and inflammatory bowel diseases. (PubMed id 8296613)9 Hauschild S....Gross W.L. (Adv. Exp. Med. Biol. 1993)
    638. In vitro interactions of c-ANCA (antibodies to proteinase 3) with human endothelial cells. (PubMed id 8296598)9 Mayet W.J....Meyer zum BA1schenfelde K.H. (Adv. Exp. Med. Biol. 1993)
    639. Wegener's granulomatosis and antineutrophil cytoplasmic autoantibodies. (PubMed id 8239356)9 Batsakis J.G. and el-Naggar A.K. (Ann. Otol. Rhinol. Laryngol. 1993)
    640. Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (PubMed id 8432453)9 Peen E....Skogh T. (Gut 1993)
    641. Anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver disease. (PubMed id 8296673)9 Mulder A.H....Kallenberg C.G. (Adv. Exp. Med. Biol. 1993)
    642. Inhibition of proteinase 3 activity by peptides derived from human epidermis. (PubMed id 8296675)9 Wiedow O....Christophers E. (Adv. Exp. Med. Biol. 1993)
    643. Clinical spectrum associated with ANCA of defined antigen specificities in 98 selected patients. (PubMed id 7681736)9 Geffriaud-Ricouard C....Lesavre P. (Clin. Nephrol. 1993)
    644. Neutrophil cytoplasmic autoantibodies after liver transplantation in patients with primary sclerosing cholangitis. (PubMed id 8301047)9 Haagsma E.B....Kallenberg C.G. (J. Hepatol. 1993)
    645. Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases. (PubMed id 8444414)9 Mulder A.H....Kallenberg C.G. (Hepatology 1993)
    646. Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis. (PubMed id 8353286)9 Mayet W.J....Meyer zum BA1schenfelde K.H. (Blood 1993)
    647. Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. (PubMed id 8103148)9 Dolman K.M....Goldschmeding R. (Lancet 1993)
    648. [Wegener's granulomatosis and ANCA-associated vasculitis: pathogenic role of autoantigens, autoantibodies, and cytokines]. (PubMed id 8344692)9 Kekow J....Gross W.L. (Immun. Infekt. 1993)
    649. Association of IgM with IgG ANCA in patients presenting with pulmonary hemorrhage. (PubMed id 1351955)9 Esnault V.L....Lockwood C.M. (Kidney Int. 1992)
    650. Interference of Wegener's granulomatosis autoantibodies with neutrophil Proteinase 3 activity. (PubMed id 1458677)9 van de Wiel B.A....Goldschmeding R. (Clin. Exp. Immunol. 1992)
    651. Anti-neutrophil cytoplasm antibodies, anti-GBM antibodies and anti-dsDNA antibodies in glomerulonephritis. (PubMed id 1478249)9 Bygren P....Wieslander J. (Eur. J. Clin. Invest. 1992)
    652. Immunodiagnostic aspects of autoantibodies against myeloperoxidase. (PubMed id 1316247)9 Ulmer M....Gross W.L. (Clin. Nephrol. 1992)
    653. Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders. (PubMed id 1466365)9 Kallenberg C.G....Tervaert J.W. (Am. J. Med. 1992)
    654. Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters. (PubMed id 1445363)9 Brubaker M.J....Rao N.V. (Biochem. Biophys. Res. Commun. 1992)
    655. [Anti-cytoplasmic antibodies of polynucle or &quot;ANCA&quot;. A new class of autoantibodies]. (PubMed id 1411180)9 NoAl L.H. (Rev Prat 1992)
    656. Stimulation of human polymorphonuclear leukocytes by recombinant human interleukin-1 beta. (PubMed id 1627264)9 Bergenfeldt M....Ohlsson K. (Biol. Chem. Hoppe-Seyler 1992)
    657. Substrate and inhibitor studies on proteinase 3. (PubMed id 1551417)9 Kam C.M....Powers J.C. (FEBS Lett. 1992)
    658. A human renal cancer line as a new antigen source for the detection of antibodies to cytoplasmic and nuclear antigens in sera of patients with Wegener's granulomatosis. (PubMed id 1717605)9 Mayet W.J....Meyer zum BA1schenfelde K.H. (J. Immunol. Methods 1991)
    659. Proteinase-3 (PR-3): a polymorphonuclear leukocyte serine proteinase. (PubMed id 2064249)9 Rao N.V....Hoidal J.R. (Ann. N. Y. Acad. Sci. 1991)
    660. Regulation of cystatin C activity by serine proteinases. (PubMed id 1801727)9 Abrahamson M....Ohlsson K. (Biomed. Biochim. Acta 1991)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5657 HGNC: 9495 AceView: PRTN3 Ensembl:ENSG00000196415 euGenes: HUgn5657
    ECgene: PRTN3 H-InvDB: PRTN3

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRTN3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Proteinase_3

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