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Aliases for PRTN3 Gene

Aliases for PRTN3 Gene

  • Proteinase 3 2 3
  • AGP7 3 4 6
  • Wegener Granulomatosis Autoantigen 2 3
  • Neutrophil Proteinase 4 3 4
  • Leukocyte Proteinase 3 3 4
  • Wegener Autoantigen 3 4
  • C-ANCA Antigen 3 4
  • Myeloblastin 2 3
  • NP-4 3 4
  • PR-3 3 4
  • P29 3 4
  • MBN 3 4
  • PR3 3 4
  • Serine Proteinase, Neutrophil 3
  • Azurophil Granule Protein 7 3
  • Serine Proteinase 2
  • EC 3.4.21.76 4
  • Neutrophil 2
  • EC 3.4.21 63
  • C-ANCA 3
  • CANCA 3
  • ACPA 3
  • MBT 3
  • NP4 3

External Ids for PRTN3 Gene

Previous GeneCards Identifiers for PRTN3 Gene

  • GC19P000922
  • GC19P000910
  • GC19P000780
  • GC19P000793
  • GC19P000498
  • GC19P000794
  • GC19P000610

Summaries for PRTN3 Gene

GeneCards Summary for PRTN3 Gene

PRTN3 (Proteinase 3) is a Protein Coding gene. Diseases associated with PRTN3 include wegener granulomatosis and subacute bacterial endocarditis. Among its related pathways are C-MYB transcription factor network. GO annotations related to this gene include enzyme binding and serine-type peptidase activity. An important paralog of this gene is ELANE.

UniProtKB/Swiss-Prot for PRTN3 Gene

  • Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters

Gene Wiki entry for PRTN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRTN3 Gene

Genomics for PRTN3 Gene

Regulatory Elements for PRTN3 Gene

Transcription factor binding sites by QIAGEN in the PRTN3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRTN3 Gene

Start:
840,960 bp from pter
End:
848,175 bp from pter
Size:
7,216 bases
Orientation:
Plus strand

Genomic View for PRTN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRTN3 Gene

Proteins for PRTN3 Gene

  • Protein details for PRTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24158-PRTN3_HUMAN
    Recommended name:
    Myeloblastin
    Protein Accession:
    P24158
    Secondary Accessions:
    • P15637
    • P18078
    • Q4VB08
    • Q4VB09
    • Q6LBM7
    • Q6LBN2
    • Q9UD25
    • Q9UQD8

    Protein attributes for PRTN3 Gene

    Size:
    256 amino acids
    Molecular mass:
    27807 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36342.1; Type=Frameshift; Positions=34, 39; Evidence={ECO:0000305}; Sequence=CAA39598.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRTN3 Gene

neXtProt entry for PRTN3 Gene

Proteomics data for PRTN3 Gene at MOPED

Selected DME Specific Peptides for PRTN3 Gene

Post-translational modifications for PRTN3 Gene

  • Glycosylation at Asn129 and Asn174

Other Protein References for PRTN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)

Domains for PRTN3 Gene

Suggested Antigen Peptide Sequences for PRTN3 Gene

Graphical View of Domain Structure for InterPro Entry

P24158

UniProtKB/Swiss-Prot:

PRTN3_HUMAN :
  • P24158
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with PRTN3: view

No data available for Gene Families for PRTN3 Gene

Function for PRTN3 Gene

Molecular function for PRTN3 Gene

GENATLAS Biochemistry:
proteinase 3,myeloblastin,Wegener autoantigen,responsive to CSF3,stimulated by SPI1,MYB,inducing factor independent growth of hematopoietic cells
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- -Xaa- > -Val- -Xaa-.
UniProtKB/Swiss-Prot Function:
Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters

Enzyme Numbers (IUBMB) for PRTN3 Gene

Gene Ontology (GO) - Molecular Function for PRTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 2679910
GO:0019899 enzyme binding IPI 17712045
genes like me logo Genes that share ontologies with PRTN3: view

Phenotypes for PRTN3 Gene

genes like me logo Genes that share phenotypes with PRTN3: view

Animal Models for PRTN3 Gene

MGI Knock Outs for PRTN3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRTN3

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PRTN3 Gene

Localization for PRTN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRTN3 Gene COMPARTMENTS Subcellular localization image for PRTN3 gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 3
lysosome 3
vacuole 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PRTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005829 cytosol IDA 17712045
GO:0005886 plasma membrane TAS --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PRTN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRTN3 Gene

Pathways for PRTN3 Gene

genes like me logo Genes that share pathways with PRTN3: view

Pathways by source for PRTN3 Gene

1 BioSystems pathway for PRTN3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PRTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007596 blood coagulation TAS --
GO:0008284 positive regulation of cell proliferation TAS 2598267
GO:0030574 collagen catabolic process IEA --
GO:0050765 negative regulation of phagocytosis IDA 17712045
genes like me logo Genes that share ontologies with PRTN3: view

Compounds for PRTN3 Gene

Compound Products

(1) ApexBio Compounds for PRTN3 Gene

Compound Action Cas Number
Gabexate mesylate Trypsin-like serine proteinases inhibitor [56974-61-9]

(44) Novoseek inferred chemical compound relationships for PRTN3 Gene

Compound -log(P) Hits PubMed IDs
serine 75.5 119
propylthiouracil 63.2 4
acpa 58.3 4
sulf 55.6 2
aebsf 53.6 1
genes like me logo Genes that share compounds with PRTN3: view

Transcripts for PRTN3 Gene

mRNA/cDNA for PRTN3 Gene

Unigene Clusters for PRTN3 Gene

Proteinase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRTN3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRTN3 Gene

No ASD Table

Relevant External Links for PRTN3 Gene

GeneLoc Exon Structure for
PRTN3
ECgene alternative splicing isoforms for
PRTN3

Expression for PRTN3 Gene

mRNA expression in normal human tissues for PRTN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRTN3 Gene

This gene is overexpressed in Whole Blood (41.9) and Spleen (4.8).

Protein differential expression in normal tissues for PRTN3 Gene

This gene is overexpressed in Neutrophil (22.5), Lavage (7.7), Cervix (6.6), Monocytes (6.3), and Spleen (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRTN3 Gene

SOURCE GeneReport for Unigene cluster for PRTN3 Gene Hs.928

genes like me logo Genes that share expressions with PRTN3: view

Expression partners for PRTN3 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PRTN3 Gene

Orthologs for PRTN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRTN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRTN3 35
  • 75.3 (n)
  • 69.32 (a)
PRTN3 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prtn3 35
  • 73.19 (n)
  • 68 (a)
Prtn3 16
Prtn3 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prtn3 35
  • 70.96 (n)
  • 68 (a)
oppossum
(Monodelphis domestica)
Mammalia PRTN3 36
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRTN3 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prtn3 35
  • 55.61 (n)
  • 52.8 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007142 35
  • 47.76 (n)
  • 38.94 (a)
Species with no ortholog for PRTN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRTN3 Gene

ENSEMBL:
Gene Tree for PRTN3 (if available)
TreeFam:
Gene Tree for PRTN3 (if available)

Paralogs for PRTN3 Gene

Paralogs for PRTN3 Gene

genes like me logo Genes that share paralogs with PRTN3: view

Variants for PRTN3 Gene

Sequence variations from dbSNP and Humsavar for PRTN3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs351109 -- 840,090(+) CCTCC(C/T)GAGTA upstream-variant-2KB
rs351110 -- 840,713(+) GTCAG(C/G)GAGGC upstream-variant-2KB
rs351111 - 844,020(+) ACGAC(A/G)TTCTC missense, reference
rs351112 -- 844,077(+) GCCAG(A/C)GGGCT intron-variant
rs629631 -- 846,041(+) GCATC(C/T)GCGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRTN3 Gene

Variant ID Type Subtype PubMed ID
nsv470101 CNV Loss 18288195
dgv3508n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
nsv910260 CNV Loss 21882294
dgv3549n71 CNV Loss 21882294
dgv3550n71 CNV Loss 21882294
dgv3551n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
dgv3554n71 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv458321 CNV Loss 19166990
dgv3558n71 CNV Loss 21882294
nsv910320 CNV Loss 21882294
esv2717797 CNV Deletion 23290073
nsv138320 CNV Loss 16902084
esv2717798 CNV Deletion 23290073
dgv3559n71 CNV Loss 21882294
dgv3560n71 CNV Loss 21882294

Relevant External Links for PRTN3 Gene

HapMap Linkage Disequilibrium report
PRTN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRTN3 Gene

Disorders for PRTN3 Gene

(81) Novoseek inferred disease relationships for PRTN3 Gene

Disease -log(P) Hits PubMed IDs
wegeners granulomatosis 96.5 133
vasculitis 92.8 125
churg-strauss syndrome 85.5 10
glomerulonephritis 81.1 15
glomerulonephritis rapidly progressive 78.9 2

Relevant External Links for PRTN3

Genetic Association Database (GAD)
PRTN3
Human Genome Epidemiology (HuGE) Navigator
PRTN3
genes like me logo Genes that share disorders with PRTN3: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PRTN3 Gene

Publications for PRTN3 Gene

  1. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. (PMID: 2258701) Campanelli D. … Gabay J.E. (J. Exp. Med. 1990) 2 3 4 23
  2. Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. (PMID: 1400430) Sturrock A.B. … Hoidal J.R. (J. Biol. Chem. 1992) 3 4 23
  3. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PMID: 1518849) Zimmer M. … Jenne D.E. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  4. Wegener autoantigen and myeloblastin are encoded by a single mRNA. (PMID: 1681549) Labbaye C. … Cayre Y.E. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  5. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. (PMID: 1688612) Ludemann J. … Gross W.L. (J. Exp. Med. 1990) 3 4 23

Products for PRTN3 Gene

Sources for PRTN3 Gene

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