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PRTN3 Gene

protein-coding GIFtS: 62
GCID: GC19P000840

Proteinase 3

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Proteinase 3¹ ²		C-ANCA Antigen² ³
AGP7² ³ ⁵		neutrophil¹
myeloblastin¹ ²		Serine Proteinase¹
Wegener Granulomatosis Autoantigen¹ ²		ACPA²
Leukocyte Proteinase 3² ³		C-ANCA²
Neutrophil Proteinase 4² ³		CANCA²
Wegener Autoantigen² ³		MBT²
MBN² ³		NP4²
NP-4² ³		Azurophil Granule Protein 7²
P29² ³		Serine Proteinase, Neutrophil²
PR-3² ³		EC 3.4.21.76³
PR3² ³		EC 3.4.21⁸

External Ids:	HGNC: 9495¹	Entrez Gene: 5657²	Ensembl: ENSG00000196415⁷	OMIM: 177020⁵	UniProtKB: P24158³

Export aliases for PRTN3 gene to outside databases

Previous GC identifers: GC19P000922 GC19P000910 GC19P000780 GC19P000793 GC19P000498 GC19P000794 GC19P000610

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRTN3 Gene:

PRTN3 (proteinase 3) is a protein-coding gene. Diseases associated with PRTN3 include subacute bacterial endocarditis, and wegener's granulomatosis. GO annotations related to this gene include serine-type peptidase activity and enzyme binding. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158

Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin,

and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to

hamsters

Gene Wiki entry for PRTN3 (Proteinase 3) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000019.10 NC_018930.2 NT_011295.12 NT_187622.1

Regulatory elements:

Regulatory transcription factor binding sites in the PRTN3 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRTN3 promoter sequence

Search Chromatin IP Primers for PRTN3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRTN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

PRTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRTN3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P000840: view genomic region (about GC identifiers)

Start:	840,963 bp from pter	End:	848,175 bp from pter
Size:	7,213 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158 (See protein sequence)

Recommended Name: Myeloblastin precursor

Size: 256 amino acids; 27807 Da

Sequence caution: Sequence=AAA36342.1; Type=Frameshift; Positions=34, 39; Sequence=CAA39598.1; Type=Erroneous

initiation;

1 PDB 3D structure from and Proteopedia for PRTN3:

1FUJ (3D)

Secondary accessions: P15637 P18078 Q4VB08 Q4VB09 Q6LBM7 Q6LBN2 Q9UD25 Q9UQD8

Explore the universe of human proteins at neXtProt for PRTN3: NX_P24158

Explore proteomics data for PRTN3 at MOPED

Post-translational modifications:

Glycosylation² at Asn129, Asn174

Selected DME Specific Peptides for PRTN3 (P24158) (see all 5)

GDSGGPL

SGGPLIC

VLTAAHC

PHSRPYMA

See PRTN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002768.3

ENSEMBL proteins:

ENSP00000234347 ENSP00000475174

PRTN3 Human Recombinant Protein Products:

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	OriGene Purified Proteins for PRTN3 OriGene Protein Over-expression Lysate for PRTN3 OriGene MassSpec for PRTN3 OriGene Custom Protein Services for PRTN3
	GenScript Custom Purified and Recombinant Proteins Services for PRTN3
	Novus Biologicals PRTN3 Proteins Novus Biologicals PRTN3 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for PRTN3
	Browse Proteins at Cloud-Clone Corp.

PRTN3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)
	OriGene Antibodies for PRTN3 OriGene Custom Antibody Services for PRTN3
	Novus Biologicals PRTN3 Antibodies
	Abcam antibodies for PRTN3
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for PRTN3
	LSBio Antibodies in human, mouse, rat for PRTN3

PRTN3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for PRTN3
	R&D Systems ELISAs for PRTN3 (Proteinase 3/Myeloblastin/PRTN3) (see all)
	GenScript Custom Assay Services for PRTN3
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:

IPR001314 Peptidase_S1A

IPR001254 Peptidase_S1

IPR018114 Peptidase_S1_AS

IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P24158

ProtoNet protein and cluster: P24158

2 Blocks protein domains:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158

Similarity: Belongs to the peptidase S1 family. Elastase subfamily

Similarity: Contains 1 peptidase S1 domain

PRTN3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: PRTN3_HUMAN, P24158

Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin,

and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to

hamsters

Catalytic activity: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- -Xaa- > -Val- -Xaa-

Genatlas biochemistry entry for PRTN3:

proteinase 3,myeloblastin,Wegener autoantigen,responsive to CSF3,stimulated by SPI1,MYB,inducing factor

independent growth of hematopoietic cells

Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.76¹

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0008236	serine-type peptidase activity	TAS	2679910
GO:0019899	enzyme binding	IPI	17712045

PRTN3 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for PRTN3:

Decreased viability

Synthetic lethal with Ras

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Prtn3):

hematopoietic system

immune system

PRTN3 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Elane/Prtn3^{Elane/tm1Deje} for PRTN3

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRTN3

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRTN3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRTN3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRTN3

miRNA Products:		Block miRNA regulation of human, mouse, rat PRTN3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate PRTN3
		SwitchGear 3'UTR luciferase reporter plasmid: PRTN3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PRTN3
		Predesigned siRNA for gene silencing in human, mouse, rat PRTN3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PRTN3

Clone Products:		OriGene clones in human, mouse for PRTN3 (see all 6) OriGene ORF clones in mouse, rat for PRTN3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PRTN3 (NM_002777)
		Sino Biological Human cDNA Clone for PRTN3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRTN3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PRTN3
		Browse ESI BIO Cell Lines and PureStem Progenitors for PRTN3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	5
plasma membrane	5
extracellular	3
lysosome	3
vacuole	3
nucleus	2
cytoskeleton	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IDA	17712045
GO:0005886	plasma membrane	IDA	17712045
GO:0031012	colocalizes with extracellular matrix	IDA	--
GO:0070062	extracellular vesicular exosome	IDA	19056867

PRTN3 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for PRTN3 About

See pathways by source

SuperPath

Contained pathways About

C-MYB transcription factor network

C-MYB transcription factor network

1 BioSystems Pathway for PRTN3

C-MYB transcription factor network

Pathway & Disease-focused RT² Profiler PCR Array including PRTN3:

Antibacterial Response in human mouse rat

Interactions:

GeneGlobe Interaction Network for PRTN3

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

Selected Interacting proteins for PRTN3 (P24158^{2, 3} ENSP00000234347⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 58)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNF	P01375³, ENSP00000398698⁴	I2D: score=1 STRING: ENSP00000398698
ENSG00000204490	P01375³	I2D: score=1
ENSG00000206439	P01375³	I2D: score=1
ENSG00000223952	P01375³	I2D: score=1
ENSG00000228321	P01375³	I2D: score=1

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	--	--
GO:0008284	positive regulation of cell proliferation	TAS	2598267
GO:0030574	collagen catabolic process	IEA	--
GO:0050765	negative regulation of phagocytosis	IDA	17712045
GO:0097029	mature dendritic cell differentiation	IDA	16478888

PRTN3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for PRTN3

Browse compounds at ApexBio

Browse Tocris compounds for PRTN3

Selected Novoseek inferred chemical compound relationships for PRTN3 gene (see all 44) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	75.5	224	2033050 (4), 1400430 (3), 11272267 (3), 1681549 (3) (see all 99)
propylthiouracil	63.2	5	10025935 (1), 8103148 (1), 17350787 (1), 17161817 (1)
acpa	58.3	5	1316247 (1), 2240162 (1), 1656761 (1), 1688612 (1)
sulf	55.6	3	7586784 (1), 7612152 (1)
aebsf	53.6	1	12354776 (1)
3,4-dichloroisocoumarin	50.6	4	14525961 (1), 9067256 (1), 1551417 (1)
pmsf	40.3	5	12960243 (1), 8033421 (1), 9500517 (1)
fmlp	32.9	1	10498622 (1)
phthalimide	32.6	4	7796053 (2), 8806743 (2)
n-formylmethionyl-leucylphenylalanine	29.6	1	10614782 (1)

PRTN3 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for PRTN3 gene:

NM_002777.3

Unigene Cluster for PRTN3:

Proteinase 3

Hs.928 [show with all ESTs]

Unigene Representative Sequence: FN647680

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000234347(uc002lqa.1) ENST00000544537(uc021umb.1)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat PRTN3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate PRTN3
		SwitchGear 3'UTR luciferase reporter plasmid: PRTN3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PRTN3
		Predesigned siRNA for gene silencing in human, mouse, rat PRTN3

Clone Products:		OriGene clones in human, mouse for PRTN3 (see all 6) OriGene ORF clones in mouse, rat for PRTN3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PRTN3 (NM_002777)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRTN3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3

Primer Products:		OriGene qPCR primer pairs and template standards for PRTN3 OriGene qSTAR qPCR primer pairs in human, mouse for PRTN3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat PRTN3
		QuantiTect SYBR Green Assays in human, mouse, rat PRTN3
		QuantiFast Probe-based Assays in human, mouse, rat PRTN3

Additional mRNA sequence:

BC096183.1 BC096184.3 BC096185.3 BC096186.3 FN647680.1 M29142.1 M75154.1 X55668.1

X56132.1 X56606.1

1 DOTS entry:

DT.310571

Selected AceView cDNA sequences (see all 27):

BV185512 BV199984 BV199995 X56606 BP428518 BI029018 BP429701 BI029214

BV199994 X56132 BP428468 BF893078 NM_002777 X55668 M75154 M29142

BE831590 AI273534 BF898648 BQ335282 BI026807 AW966814 BI028421 D19823

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PRTN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

PRTN3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Blood (Hematopoietic System) fully expand to see all 8 entries
Hematopoietic Stem Cells Hematopoietic Bone Marrow
Bone marrow-derived hematopoietic stem cells (family)
Bone Marrow CD34+ Cells
bone marrow mononuclear cells

Bone (Muscoskeletal System) fully expand to see all 2 entries
Bone Marrow
bone marrow

Liver (Hepatobiliary System)
Fetal Liver CD34+ Cells

Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Mononuclear Myocytes Hyoid Arch Muscles

PRTN3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

PRTN3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.928

Pathway & Disease-focused RT² Profiler PCR Array including PRTN3:

Antibacterial Response in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for PRTN3 OriGene qSTAR qPCR primer pairs in human, mouse for PRTN3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat PRTN3
		QuantiTect SYBR Green Assays in human, mouse, rat PRTN3
		QuantiFast Probe-based Assays in human, mouse, rat PRTN3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for PRTN3 gene from Selected species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Prtn3^{1 , 5}	proteinase 3^{1, 5}	73.19(n)¹ 68(a)¹	10 (39.72 cM)⁵ 19152¹ NM_011178.2¹ NP_035308.2¹ 79874476⁵
tropical clawed frog (Xenopus tropicalis)	Amphibia	prtn3¹	proteinase 3	55.61(n) 52.8(a)	448597 NM_001006846.1 NP_001006847.1
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP007142¹	AgaP_AGAP007142	47.76(n) 38.94(a)	1269964 XM_308619.3 XP_308619.3

ENSEMBL Gene Tree for PRTN3 (if available)
TreeFam Gene Tree for PRTN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PRTN3 gene

GZMH² GZMK² PRSS57² CTSG² CFD² ELANE² CMA1² AZU1²

GZMM² GZMA² GZMB²

Selected SIMAP similar genes for PRTN3 using alignment to 3 protein entries: PRTN3_HUMAN (see all proteins) (see all similar genes):

ELANE ELA2 AZU1 PRSS1 CTSG CMA1

PRSS2 TRY8 PRSS3 CTRL GZMK LPA

KLK4 DF KLK6 APS CFD CELA3A

PRTN3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149212424^1,2		--	839030(+)	`ATGGGC/TTTCGA`	1	--	us2k¹		0	--	--	--	--
rs143255767^1,2		--	839070(+)	`CGCCCA/GGGACT`	1	--	us2k¹		0	--	--	--	--
rs73919863^1,2	C,F	--	839097(+)	`GAGGCC/AACCCA`	1	--	us2k¹		3		WA CSA	122
rs148296480^1,2	C	--	839147(+)	`CAGCTC/GTCCTC`	1	--	us2k¹		0	--	--	--	--
rs12052108^1,2	C,F,A,H	--	839158(+)	`AATGGC/TCCCAA`	1	--	us2k¹		22		NS EA NA WA CSA	2347
rs140523004^1,2		--	839189(+)	`GACTGA/CGCCCG`	1	--	us2k¹		0	--	--	--	--
rs79361221^1,2	F	--	839193(+)	`GCGCCC/GGCTGG`	1	--	us2k¹		0	--	--	--	--
rs138032111^1,2		--	839269(+)	`ATACTC/TAGGGG`	1	--	us2k¹		0	--	--	--	--
rs10410826^1,2	C,F	--	839272(+)	`CTCAGG/TGGGCT`	1	--	us2k¹		4		NA WA CSA	124
rs62132294^1,2	C,F	--	839298(+)	`ATTTGG/CAATCA`	1	--	us2k¹		3		NA EA	242

HapMap Linkage Disequilibrium report for PRTN3 (840963 - 848175 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for PRTN3 (see all 21): About this table

Variant ID	Type	Subtype	PubMed ID
esv2717797	CNV	Deletion	23290073
esv2717798	CNV	Deletion	23290073
nsv470101	CNV	Loss	18288195
dgv3550n71	CNV	Loss	21882294
nsv910292	CNV	Loss	21882294
nsv138320	CNV	Loss	16902084
dgv3558n71	CNV	Loss	21882294
dgv3555n71	CNV	Loss	21882294
dgv3552n71	CNV	Loss	21882294
dgv3554n71	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PRTN3

DNA2.0 Custom Variant and Variant Library Synthesis for PRTN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 177020 OMIM disorders: --

Selected diseases for PRTN3 (see all 92):
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subacute bacterial endocarditis wegener's granulomatosis mononeuritis multiplex mononeuritis

mononeuropathy granulomatosis with polyangiitis rapidly progressive glomerulonephritis endocarditis

scleritis alpha 1-antitrypsin deficiency vasculitis relapsing polychondritis

crescentic glomerulonephritis mixed connective tissue disease polyarteritis nodosa churg-strauss syndrome

microscopic polyangiitis cholangitis pyoderma gangrenosum glomerulonephritis

12 diseases from the University of Copenhagen DISEASES database for PRTN3:

Vasculitis Hypersensitivity reaction type II disease Glomerulonephritis Rheumatoid arthritis

Polyarteritis nodosa Scleritis Sinusitis Connective tissue disease

Endocarditis Ulcerative colitis Lung disease Mononeuropathy

PRTN3 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Selected Novoseek inferred disease relationships for PRTN3 gene (see all 81) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
wegeners granulomatosis	96.5	304	8157982 (3), 15498036 (3), 17005932 (3), 19881350 (3) (see all 99)
vasculitis	92.8	228	12605707 (4), 16792675 (4), 15958084 (3), 8499060 (2) (see all 99)
churg-strauss syndrome	85.5	15	12687504 (1), 17521322 (1), 10896971 (1), 8381764 (1) (see all 10)
glomerulonephritis	81.1	20	10405206 (2), 10844589 (1), 11034396 (1), 11092351 (1) (see all 14)
glomerulonephritis rapidly progressive	78.9	2	7847352 (1), 9306336 (1)
vasculitis leukocytoclastic	71.9	8	7626983 (1), 7554378 (1), 11838849 (1), 11208991 (1) (see all 6)
polyarteritis nodosa	64.4	6	7754755 (2), 7907475 (1)
pulmonary hemorrhage	57.2	1	1351955 (1)
inflammation	55.5	43	10101005 (2), 7829874 (1), 10471824 (1), 11272269 (1) (see all 28)
autoimmune diseases	55.2	8	14736010 (1), 10720938 (1), 16026591 (1), 18953353 (1) (see all 7)

Genetic Association Database (GAD): PRTN3
Human Genome Epidemiology (HuGE) Navigator: PRTN3 (7 documents)

Export disorders for PRTN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PRTN3 gene, integrated from 10 sources (see all 670):
(articles sorted by number of sources associating them with PRTN3)

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Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. (PubMed id 2258701)^{1, 2, 3, 9} Campanelli D....Gabay J.E. (J. Exp. Med. 1990)
Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. (PubMed id 2033050)^{1, 2, 9} Rao N.V....Hoidal J.R. (J. Biol. Chem. 1991)
Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. (PubMed id 1400430)^{1, 2, 9} Sturrock A.B.... Hoidal J.R. (J. Biol. Chem. 1992)
Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism. (PubMed id 16792675)^{1, 4, 9} Abdgawad M....Segelmark M. (Clin. Exp. Immunol. 2006)
Proteinase 3 gene polymorphisms and Wegener's granulomatosis. (PubMed id 11115080)^{1, 4, 9} Gencik M....Fricke H. (Kidney Int. 2000)
Wegener autoantigen and myeloblastin are encoded by a single mRNA. (PubMed id 1681549)^{1, 2, 9} Labbaye C.... Cayre Y.E. (Proc. Natl. Acad. Sci. U.S.A. 1991)
Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme. (PubMed id 2121162)^{1, 2, 9} Ohlsson K.... Rosengren M. (Biol. Chem. Hoppe-Seyler 1990)
The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. (PubMed id 8757293)^{1, 2, 9} Fujinaga M.... James M.N.G. (J. Mol. Biol. 1996)
Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PubMed id 1518849)^{1, 2, 9} Zimmer M....Jenne D.E. (Proc. Natl. Acad. Sci. U.S.A. 1992)
Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia. (PubMed id 9924693)^{1, 2, 9} Clave E.... Barrett A.J. (J. Immunother. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5657	HGNC: 9495	AceView: PRTN3	Ensembl:ENSG00000196415	euGenes: HUgn5657
ECgene: PRTN3	H-InvDB: PRTN3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PRTN3	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Proteinase_3

Intellectual Property for PRTN3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PRTN3 gene:
Search GeneIP for patents involving PRTN3

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PRTN3 (Gene Symbol)
Proteinase 3
AGP7
myeloblastin
Wegener Granulomatosis Autoantigen
Leukocyte Proteinase 3
Neutrophil Proteinase 4
Wegener Autoantigen
MBN
NP-4
P29
PR-3
PR3
C-ANCA Antigen
neutrophil
Serine Proteinase
ACPA
C-ANCA
CANCA
MBT
NP4
Azurophil Granule Protein 7
Serine Proteinase, Neutrophil
EC 3.4.21.76
EC 3.4.21

Spondylitis Ankylosing
Nephritis
Arthritis Reactive
Genetic Susceptibility
sepsis
Cystic Fibrosis
Colitis Ulcerative
Systemic Disease
Atherosclerosis
Liver diseases
Breast Cancer
Sjogrens Syndrome Primary
Hyperthyroidism
Asthma
BILIARY CIRRHOSIS PRIMARY
cell damage
Cancer
Shock
Polyarteritis Nodosa
CHOLANGITIS PRIMARY SCLEROSING
RENAL DISEASE
Nephropathy IGA
Inflammation
Proteinuria
Neutropenia
Anemia
Pulmonary Disease Chronic Obstructive
Renal Failure
Rheumatoid Arthritis
Tumors
Necrosis
mimicry
Autoimmunity
Renal Failure Acute
virus infection
Hepatitis C
Chronic Disease
Mononeuritis Multiplex
Myeloid Leukemia
Autoimmune Diseases
Melanoma
HEMATURIA MICROSCOPIC
Vasculitis
alpha 1-Antitrypsin Deficiency
LEUKEMIA BASOPHILIC
Subacute Bacterial Endocarditis
Systemic Inflammatory Response Syndrome
ACUTE LEUKEMIA
Polyarthritis
Infectious disease
Myeloid Leukemia Chronic
Churg-Strauss Syndrome
Leukemia
Mixed Connective Tissue Disease
Sjogrens Syndrome
Bronchitis Chronic
Pulmonary hemorrhage
Inflammatory Bowel Diseases
Wilms tumor
Respiratory Tract Infections
Sinusitis
Ascites
Eosinophilia
Bleeding
Lung diseases
Carcinoma Squamous Cell
Vasculitis Leukocytoclastic
Leukemia Promyelocytic Acute
GLOMERULONEPHRITIS RAPIDLY PROGRESSIVE
Autoimmune Response
STROKE
Wegeners Granulomatosis
Vascular Diseases
Granuloma
Glomerulonephritis
Sclerosis Systemic
Peritonitis
LEUKAEMIA LYMPHOCYTIC
Renal Failure Chronic
Arthritis
Lupus Erythematosus Systemic

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