PRTN3 Gene

Aliases
for PRTN3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC19P000922 GC19P000910 GC19P000780 GC19P000793 GC19P000498 GC19P000794 GC19P000610

Summaries
for PRTN3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for PRTN3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9  NC_018930.2  NT_011295.12  NT_187622.1  

SwitchGear Promoter luciferase reporter plasmid: PRTN3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRTN3

PRTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000840:  view genomic region     (about GC identifiers)

Proteins
for PRTN3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for PRTN3:

1FUJ (3D)    

Explore the universe of human proteins at neXtProt for PRTN3: NX_P24158

Explore proteomics data for PRTN3 at MOPED

Post-translational modifications: 

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	antibodies-online proteins for PRTN3 (26 products)
	antibodies-online peptides for PRTN3

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	antibodies-online kits for PRTN3 (23 products)

Domains /
Families
for PRTN3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P24158

Find genes that share domains with PRTN3           About GenesLikeMe

Function
for PRTN3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Prtn3)

genOway: Develop your customized and physiologically relevant rodent model for PRTN3

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PRTN3

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		Sino Biological Human cDNA Clone for PRTN3
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3

Localization
for PRTN3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	5
plasma membrane	5
extracellular	3
lysosome	3
vacuole	3
nucleus	2
cytoskeleton	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for PRTN3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for PRTN3 About     See pathways by source

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	SuperPath	Contained pathways About
1	C-MYB transcription factor network	C-MYB transcription factor network

1 BioSystems Pathway for PRTN3

C-MYB transcription factor network

Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for PRTN3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for PRTN3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for PRTN3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PRTN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

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Blood (Hematopoietic System)    fully expand to see all 8 entries
Hematopoietic Stem Cells Hematopoietic Bone Marrow
Bone marrow-derived hematopoietic stem cells (family)
Bone Marrow CD34+ Cells
bone marrow mononuclear cells
Bone (Muscoskeletal System)    fully expand to see all 2 entries
Bone Marrow
bone marrow
Liver (Hepatobiliary System)
Fetal Liver CD34+ Cells
Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
Mononuclear Myocytes Hyoid Arch Muscles

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		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRTN3
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3

Orthologs
for PRTN3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for PRTN3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for PRTN3 gene

GZMH²  GZMK²  PRSS57²  CTSG²  CFD²  ELANE²  CMA1²  AZU1²  

GZMM²  GZMA²  GZMB²  

Selected SIMAP similar genes for PRTN3 using alignment to 3 protein entries:     PRTN3_HUMAN (see all proteins) (see all similar genes):

ELANE    ELA2    AZU1    PRSS1    CTSG    CMA1

PRSS2    TRY8    PRSS3    CTRL    GZMK    LPA

KLK4    DF    KLK6    APS    CFD    CELA3A

Find genes that share paralogs with PRTN3           About GenesLikeMe

Genomic Variants
for PRTN3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PRTN3 (see all 334)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1492124241,2		--	839030(+)	ATGGGC/TTTCGA	1	--	us2k1		0	--	--	--	--
rs1432557671,2		--	839070(+)	CGCCCA/GGGACT	1	--	us2k1		0	--	--	--	--
rs739198631,2	C,F	--	839097(+)	GAGGCC/AACCCA	1	--	us2k1		3		WA CSA	122
rs1482964801,2	C	--	839147(+)	CAGCTC/GTCCTC	1	--	us2k1		0	--	--	--	--
rs120521081,2	C,F,A,H	--	839158(+)	AATGGC/TCCCAA	1	--	us2k1		22		NS EA NA WA CSA	2347
rs1405230041,2		--	839189(+)	GACTGA/CGCCCG	1	--	us2k1		0	--	--	--	--
rs793612211,2	F	--	839193(+)	GCGCCC/GGCTGG	1	--	us2k1		0	--	--	--	--
rs1380321111,2		--	839269(+)	ATACTC/TAGGGG	1	--	us2k1		0	--	--	--	--
rs104108261,2	C,F	--	839272(+)	CTCAGG/TGGGCT	1	--	us2k1		4		NA WA CSA	124
rs621322941,2	C,F	--	839298(+)	ATTTGG/CAATCA	1	--	us2k1		3		NA EA	242

HapMap Linkage Disequilibrium report for PRTN3 (840963 - 848175 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for PRTN3 (see all 21):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2717797	CNV	Deletion	23290073
esv2717798	CNV	Deletion	23290073
nsv470101	CNV	Loss	18288195
dgv3550n71	CNV	Loss	21882294
nsv910292	CNV	Loss	21882294
nsv138320	CNV	Loss	16902084
dgv3558n71	CNV	Loss	21882294
dgv3555n71	CNV	Loss	21882294
dgv3552n71	CNV	Loss	21882294
dgv3554n71	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PRTN3

DNA2.0 Custom Variant and Variant Library Synthesis for PRTN3

Disorders / Diseases
for PRTN3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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14 diseases for PRTN3

Selected Novoseek inferred disease relationships for PRTN3 gene (see all 81)    About this table

Publications
for PRTN3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PRTN3 gene, integrated from 10 sources (see all 670): (articles sorted by number of sources associating them with PRTN3)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. (PubMed id 2258701)^{1, 2, 3, 9} Campanelli D....Gabay J.E. (J. Exp. Med. 1990)
2. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. (PubMed id 2033050)^{1, 2, 9} Rao N.V....Hoidal J.R. (J. Biol. Chem. 1991)
3. Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. (PubMed id 1400430)^{1, 2, 9} Sturrock A.B.... Hoidal J.R. (J. Biol. Chem. 1992)
4. Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism. (PubMed id 16792675)^{1, 4, 9} Abdgawad M....Segelmark M. (Clin. Exp. Immunol. 2006)
5. Proteinase 3 gene polymorphisms and Wegener's granulomatosis. (PubMed id 11115080)^{1, 4, 9} Gencik M....Fricke H. (Kidney Int. 2000)
6. Wegener autoantigen and myeloblastin are encoded by a single mRNA. (PubMed id 1681549)^{1, 2, 9} Labbaye C.... Cayre Y.E. (Proc. Natl. Acad. Sci. U.S.A. 1991)
7. Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme. (PubMed id 2121162)^{1, 2, 9} Ohlsson K.... Rosengren M. (Biol. Chem. Hoppe-Seyler 1990)
8. The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. (PubMed id 8757293)^{1, 2, 9} Fujinaga M.... James M.N.G. (J. Mol. Biol. 1996)
9. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PubMed id 1518849)^{1, 2, 9} Zimmer M....Jenne D.E. (Proc. Natl. Acad. Sci. U.S.A. 1992)
10. Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia. (PubMed id 9924693)^{1, 2, 9} Clave E.... Barrett A.J. (J. Immunother. 1999)

External Searches for PRTN3 gene

Genome Databases showing PRTN3 gene

Other Databases showing PRTN3 gene

Specialized Databases showing PRTN3 gene

Products
for PRTN3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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