Aliases for PRTN3 Gene
Aliases for PRTN3 Gene
External Ids for PRTN3 Gene
- HGNC: 9495
- Entrez Gene: 5657
- Ensembl: ENSG00000196415
- OMIM: 177020
- UniProtKB: P24158
Previous GeneCards Identifiers for PRTN3 Gene
- GC19P000922
- GC19P000910
- GC19P000780
- GC19P000793
- GC19P000498
- GC19P000794
- GC19P000610
Summaries for PRTN3 Gene
GeneCards Summary for PRTN3 Gene
PRTN3 (Proteinase 3) is a Protein Coding gene. Diseases associated with PRTN3 include Wegener Granulomatosis and Vasculitis. Among its related pathways are Cytokine Signaling in Immune system and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include enzyme binding and serine-type peptidase activity. An important paralog of this gene is ELANE.
UniProtKB/Swiss-Prot for PRTN3 Gene
-
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).
Additional gene information for PRTN3 Gene
- Monarch Initiative
- Search for PRTN3 at DataMed
- Search for PRTN3 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRTN3 Gene
Genomics for PRTN3 Gene
GeneHancer (GH) Regulatory Elements for PRTN3 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19I000840 | Promoter/Enhancer | 1.3 | EPDnew Ensembl | 550.8 | +0.0 | 41 | 0.8 | HDGF PKNOX1 ARNT NFRKB ZNF366 EGR2 SMARCA5 ZBTB2 NCOA1 ELF1 | PRTN3 ELANE | |
GH19I000839 | Enhancer | 0.4 | Ensembl | 550.8 | -1.6 | -1559 | 0.8 | GLIS1 CEBPB | PRTN3 GC19M000833 | |
GH19I000747 | Promoter/Enhancer | 2.1 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 13.3 | -89.0 | -89045 | 9.4 | PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZBTB7B BRCA1 ZNF143 FOS SP5 | MISP PRTN3 ELANE CFD FSTL3 PLPP2 TPGS1 GC19P000749 GC19P000763 PALM | |
GH19I000906 | Enhancer | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 13.1 | +67.6 | 67598 | 4.7 | HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B | ARHGAP45 R3HDM4 MIDN ABCA7 CFD ELANE PRTN3 GZMM DAZAP1 SBNO2 | |
GH19I000823 | Enhancer | 1.2 | FANTOM5 ENCODE | 12.4 | -17.2 | -17248 | 0.5 | ATF1 POLR2B ZNF766 ATF7 NCOA1 REST ZNF592 MBD2 ATF4 GMEB1 | AZU1 PLPPR3 GC19P000823 PRTN3 ELANE PRSS57 BSG PTBP1 |
- Top Transcription factor binding sites by QIAGEN in the PRTN3 gene promoter:
Regulatory Element Products
Genomic Locations for PRTN3 Gene
- chr19:840,960-848,175
- (GRCh38/hg38)
- Size:
- 7,216 bases
- Orientation:
- Plus strand
- chr19:840,963-848,175
- (GRCh37/hg19)
Genomic View for PRTN3 Gene
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC


RefSeq DNA sequence for PRTN3 Gene
Proteins for PRTN3 Gene
-
Protein details for PRTN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24158-PRTN3_HUMAN
- Recommended name:
- Myeloblastin
- Protein Accession:
- P24158
- P15637
- P18078
- Q4VB08
- Q4VB09
- Q6LBM7
- Q6LBN2
- Q9UD25
- Q9UQD8
Protein attributes for PRTN3 Gene
- Size:
- 256 amino acids
- Molecular mass:
- 27807 Da
- Quaternary structure:
-
- May form dimers (PubMed:28240246). Interacts with CD177; the interaction tethers PRTN3 to the cell surface; the interaction is direct (PubMed:17244676, PubMed:28240246).
- SequenceCaution:
-
- Sequence=AAA36342.1; Type=Frameshift; Positions=34, 39; Evidence={ECO:0000305}; Sequence=CAA39598.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PRTN3 Gene
Selected DME Specific Peptides for PRTN3 Gene
- P24158:
-
- VLTAAHC
- GDSGGPL
- SGGPLIC
- PHSRPYMA
- VLQELNVTVVT
Post-translational modifications for PRTN3 Gene
- Glycosylation at isoforms=129 and isoforms=174
Other Protein References for PRTN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)
- Novus Biologicals Antibodies for PRTN3
-
Abcam antibodies for PRTN3
-
Cloud-Clone Corp. Antibodies for PRTN3
- Invitrogen Antibodies for PRTN3
- GeneTex PRTN3 antibody for PRTN3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRTN3
Protein Products
-
OriGene Purified Proteins for PRTN3
- Search Origene for MassSpec and Protein Over-expression Lysates for PRTN3
- Origene Custom Protein Services for PRTN3
- ProSpec Recombinant Proteins for PRTN3
-
Cloud-Clone Corp. Proteins for PRTN3
- Search GeneTex for Proteins for PRTN3
-
ProSci Proteins for PRTN3
-
Abcam proteins for PRTN3
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)
-
Cloud-Clone Corp. Assay Kits for PRTN3
-
Abcam assays for PRTN3
Domains & Families for PRTN3 Gene
Gene Families for PRTN3 Gene
- Human Protein Atlas (HPA):
-
- Candidate cardiovascular disease genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for PRTN3 Gene
Suggested Antigen Peptide Sequences for PRTN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P24158- Family:
-
- Belongs to the peptidase S1 family. Elastase subfamily.
Function for PRTN3 Gene
Molecular function for PRTN3 Gene
- GENATLAS Biochemistry:
- proteinase 3,myeloblastin,Wegener autoantigen,responsive to CSF3,stimulated by SPI1,MYB,inducing factor independent growth of hematopoietic cells
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 7.4. {ECO:0000269 PubMed:3198760};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- -Xaa- > -Val- -Xaa-.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by phenylmethanesulfonyl fluoride (PMSF) and diisopropyl fluorophosphate (DFP).
- UniProtKB/Swiss-Prot Function:
- Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).
- UniProtKB/Swiss-Prot Induction:
- Induced during CSF3/G-CSF-mediated neutrophil differentiation.
Enzyme Numbers (IUBMB) for PRTN3 Gene
Phenotypes From GWAS Catalog for PRTN3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004252 | serine-type endopeptidase activity | IMP | 22266279 |
GO:0005102 | receptor binding | IPI | 17244676 |
GO:0005515 | protein binding | IPI | 16488976 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008236 | serine-type peptidase activity | IEA,TAS | 2679910 |
Phenotypes for PRTN3 Gene
- MGI mutant phenotypes for PRTN3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PRTN3:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Effect on mitosis
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability with paclitaxel
- Decreased viability
Animal Models for PRTN3 Gene
- MGI Knock Outs for PRTN3:
-
- Prtn3 tm1.1Hrlu
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRTN3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PRTN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRTN3 gene
- Search ViGene Biosciences for PRTN3
CRISPR Products
-
OriGene CRISPR knockouts for PRTN3
- genomics-online: gRNA clones - Search results for available PRTN3 gene related products
- Applied Biological Materials CRISPR for PRTN3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRTN3
- GenScript: Design CRISPR guide RNA sequences for PRTN3
miRNA Products
- Search ViGene Biosciences for PRTN3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRTN3
- Browse OriGene Inhibitory RNA Products For PRTN3
- genomics-online: shRNA clones - Search results for available PRTN3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRTN3 gene
Clone Products
- Sino Biological Human cDNA Clone for PRTN3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PRTN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRTN3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PRTN3 gene related products
- orf clones - Search results for available PRTN3 gene related products
- Applied Biological Materials Clones for PRTN3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRTN3
-
ViGene Biosciences adenoviral particle packaged cDNA for PRTN3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRTN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRTN3 gene
No data available for miRNA , Transcription Factor Targets and HOMER Transcription for PRTN3 Gene
Localization for PRTN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRTN3 Gene
- Cytoplasmic granule. Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Membrane raft; Peripheral membrane protein; Extracellular side. Note=Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208). Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246). Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279). {ECO:0000269 PubMed:18462208, ECO:0000269 PubMed:2033050, ECO:0000269 PubMed:22266279, ECO:0000269 PubMed:28240246, ECO:0000269 PubMed:3198760, ECO:0000269 PubMed:7897245}.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | HDA,IDA | 16502470 |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0031012 | colocalizes_with extracellular matrix | IDA | 20551380 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRTN3 Gene
Pathways & Interactions for PRTN3 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Formation of Fibrin Clot (Clotting Cascade) | ||
3 | Cytokine Signaling in Immune system | ||
4 | Defensins | ||
5 | Response to elevated platelet cytosolic Ca2+ |
.44
|
Pathways by source for PRTN3 Gene
1 BioSystems pathway for PRTN3 Gene
9 Reactome pathways for PRTN3 Gene
Interacting Proteins for PRTN3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IMP,IEA | 22266279 |
GO:0006509 | membrane protein ectodomain proteolysis | IMP | 23202369 |
GO:0007596 | blood coagulation | TAS | -- |
GO:0008284 | positive regulation of cell proliferation | TAS | 2598267 |
GO:0019730 | antimicrobial humoral response | TAS | -- |
No data available for SIGNOR curated interactions for PRTN3 Gene
Drugs & Compounds for PRTN3 Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
(1) ApexBio Compounds for PRTN3 Gene
Compound | Action | Cas Number |
---|---|---|
Gabexate mesylate | Trypsin-like serine proteinases inhibitor | 56974-61-9 |
Transcripts for PRTN3 Gene
mRNA/cDNA for PRTN3 Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (27) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PRTN3
- genomics-online: gRNA clones - Search results for available PRTN3 gene related products
- Applied Biological Materials CRISPR for PRTN3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRTN3
- GenScript: Design CRISPR guide RNA sequences for PRTN3
miRNA Products
- Search ViGene Biosciences for PRTN3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRTN3
- Browse OriGene Inhibitory RNA Products For PRTN3
- genomics-online: shRNA clones - Search results for available PRTN3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRTN3 gene
Clone Products
- Sino Biological Human cDNA Clone for PRTN3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PRTN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRTN3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available PRTN3 gene related products
- orf clones - Search results for available PRTN3 gene related products
- Applied Biological Materials Clones for PRTN3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PRTN3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Bone (Muscoskeletal System)
- Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for PRTN3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRTN3 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRTN3 Gene:
PRTN3SOURCE GeneReport for Unigene cluster for PRTN3 Gene:
Hs.928mRNA Expression by UniProt/SwissProt for PRTN3 Gene:
P24158-PRTN3_HUMANEvidence on tissue expression from TISSUES for PRTN3 Gene
- Blood(4.6)
- Bone marrow(3.4)
- Lung(2.7)
- Kidney(2.6)
- Spleen(2.4)
- Heart(2.1)
- Skin(2)
- Nervous system(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PRTN3 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- nervous
- respiratory
- skeleton
- urinary
- brain
- ear
- eye
- face
- head
- larynx
- mouth
- neck
- nose
- pituitary gland
- sinus
- skull
- bronchus
- esophagus
- heart
- lung
- trachea
- kidney
- stomach
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
- blood
- blood vessel
- coagulation system
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for PRTN3
-
OriGene qPCR primer pairs and template standards for PRTN3
- genomics-online: primer clones - Search results for available PRTN3 gene related products
Orthologs for PRTN3 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PRTN3 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | PRTN3 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Prtn3 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Prtn3 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PRTN3 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | prtn3 33 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007142 33 |
|
- Species where no ortholog for PRTN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for PRTN3 Gene
(51) SIMAP similar genes for PRTN3 Gene using alignment to 3 proteins:
- ELANE
- ELA2
- AZU1
- PRSS1
- CTSG
- CMA1
- PRSS2
- TRY8
- PRSS3
- GZMK
- CTRL
- LPA
- KLK4
- DF
- KLK6
- CFD
- APS
- OVCH1
- KLK5
- CELA3A
- KLK7
- KLK15
- PROC
- KLK3
- GZMA
- PRSSL1
- PRSS57
- KLK11
- DKFZp779M0222
- KLK8
- KLK13
- KLK1
- GZMB
- F9
- KLK14
- CELA3B
- PLAU
- factor IX F9
- TPSD1
- TMPRSS6
- TMPRSS12
- TMPRSS11D
- F9 p22
- ELA3A
- ELA2B
- CTRC
- CTRB1
- CELA2B
- CELA1
- F12
- CTRB2
Variants for PRTN3 Gene
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000024445 | -- | 841,279(+) | C/T | intron_variant | |
rs1001347644 | -- | 844,276(+) | T/C | intron_variant | |
rs1001619269 | -- | 839,741(+) | G/A | upstream_transcript_variant | |
rs1001960501 | -- | 843,436(+) | T/C | intron_variant | |
rs1002029059 | -- | 839,586(+) | G/A | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv134n111 | CNV | deletion | 26073780 |
dgv1679n106 | CNV | deletion | 24896259 |
esv2717797 | CNV | deletion | 23290073 |
esv2717798 | CNV | deletion | 23290073 |
nsv1112307 | CNV | deletion | 24896259 |
nsv138320 | CNV | deletion | 16902084 |
nsv458321 | CNV | loss | 19166990 |
nsv470101 | CNV | loss | 18288195 |
nsv578167 | CNV | loss | 21841781 |
nsv578172 | CNV | loss | 21841781 |
nsv953938 | CNV | deletion | 24416366 |
Additional Variant Information for PRTN3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRTN3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRTN3 Gene
Disorders for PRTN3 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
wegener granulomatosis |
|
|
vasculitis |
|
|
anca-associated vasculitis |
|
|
rapidly progressive glomerulonephritis |
|
|
churg-strauss syndrome |
|
UniProtKB/Swiss-Prot
PRTN3_HUMAN- Note=Is the major autoantigen in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (Wegeners granulomatosis) (PubMed:2377228, PubMed:2679910). This complex, systemic disease is characterized by granulomatous inflammation with necrotizing lesions in the respiratory tract, glomerulonephritis, vasculitis, and anti-neutrophil cytoplasmatic autoantibodies detected in patient sera (PubMed:2377228, PubMed:2679910). PRTN3 causes emphysema when administered by tracheal insufflation to hamsters (PubMed:3198760). {ECO:0000269 PubMed:3198760, ECO:0000303 PubMed:2377228, ECO:0000303 PubMed:2679910}.
Additional Disease Information for PRTN3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PRTN3 Gene
Publications for PRTN3 Gene
- Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. (PMID: 2258701) Campanelli D … Gabay JE (The Journal of experimental medicine 1990) 2 3 4 22 58
- Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing. (PMID: 18462208) von Vietinghoff S … Kettritz R (Clinical and experimental immunology 2008) 3 4 22 58
- Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism. (PMID: 16792675) Abdgawad M … Segelmark M (Clinical and experimental immunology 2006) 3 22 44 58
- Proteinase 3 gene polymorphisms and Wegener's granulomatosis. (PMID: 11115080) Gencik M … Fricke H (Kidney international 2000) 3 22 44 58
- The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. (PMID: 8757293) Fujinaga M … James MN (Journal of molecular biology 1996) 3 4 22 58
Products for PRTN3 Gene
- R&D Systems Antibodies for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Cell Selection and Detection Kits
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- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PRTN3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PRTN3
- Search Origene for MassSpec and Protein Over-expression Lysates for PRTN3
- Origene Custom Protein Services for PRTN3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRTN3
- Browse OriGene Inhibitory RNA Products For PRTN3
- OriGene qPCR primer pairs and template standards for PRTN3
- OriGene qPCR primer pairs for PRTN3
- OriGene CRISPR knockouts for PRTN3
- OriGene ORF clones in human for PRTN3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRTN3
- GenScript: Next-day shipping of latest version cDNA ORF clones for PRTN3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PRTN3
- GenScript Custom Assay Services for PRTN3
- GenScript Custom overexpressing Cell Line Services for PRTN3
- GenScript: Design CRISPR guide RNA sequences for PRTN3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PRTN3
- Sino Biological Human cDNA Clone for PRTN3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PRTN3
- Novus Biologicals lysates and proteins for PRTN3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for PRTN3
- Abcam proteins for PRTN3
- Abcam assays for PRTN3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PRTN3
- Cloud-Clone Corp. Antibodies for PRTN3
- Cloud-Clone Corp. Proteins for PRTN3
- Cloud-Clone Corp. Assay Kits for PRTN3
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for PRTN3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for PRTN3
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRTN3
- VectorBuilder custom plasmid, inducible vectors for PRTN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRTN3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 201 available PRTN3 Antibodies ranked by validation data
- Compare Top PRTN3 Antibodies
- antibodies-online: Search results for 43 available PRTN3 Elisa Kits ranked by validation data
- Compare Top PRTN3 Elisa Kits
- antibodies-online: Search results for 32 available PRTN3 Proteins ranked by validation data
- Compare Top PRTN3 Proteins
- GeneTex PRTN3 antibody for PRTN3
- Search GeneTex for Proteins for PRTN3
- ViGene Biosciences adenoviral particle packaged cDNA for PRTN3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PRTN3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PRTN3 gene
- Search ViGene Biosciences for PRTN3
- Santa Cruz Biotechnology (SCBT) Antibodies for PRTN3
- Search Santa Cruz Biotechnology (SCBT) for PRTN3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRTN3
- Search for PRTN3 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for PRTN3
- Horizon Cell Lines for PRTN3
- genomics-online: cdna clones - Search results for available PRTN3 gene related products
- orf clones - Search results for available PRTN3 gene related products
- genomics-online: gRNA clones - Search results for available PRTN3 gene related products
- genomics-online: primer clones - Search results for available PRTN3 gene related products
- genomics-online: shRNA clones - Search results for available PRTN3 gene related products
Sources for PRTN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew