Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRTN3 Gene

protein-coding   GIFtS: 61
GCID: GC19P000840

Proteinase 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proteinase 31 2     C-ANCA Antigen2 3
AGP72 3 5     neutrophil1
myeloblastin1 2     Serine Proteinase1
Wegener Granulomatosis Autoantigen1 2     ACPA2
Leukocyte Proteinase 32 3     C-ANCA2
Neutrophil Proteinase 42 3     CANCA2
Wegener Autoantigen2 3     MBT2
MBN2 3     NP42
NP-42 3     Azurophil Granule Protein 72
P292 3     Serine Proteinase, Neutrophil2
PR-32 3     EC 3.4.21.763
PR32 3     EC 3.4.218

External Ids:    HGNC: 94951   Entrez Gene: 56572   Ensembl: ENSG000001964157   OMIM: 1770205   UniProtKB: P241583   

Export aliases for PRTN3 gene to outside databases

Previous GC identifers: GC19P000922 GC19P000910 GC19P000780 GC19P000793 GC19P000498 GC19P000794 GC19P000610


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PRTN3 Gene: 
PRTN3 (proteinase 3) is a protein-coding gene. Diseases associated with PRTN3 include wegener's granulomatosis, and subacute bacterial endocarditis. GO annotations related to this gene include serine-type peptidase activity and enzyme binding. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin,
and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to
hamsters

Gene Wiki entry for PRTN3 (Proteinase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRTN3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRTN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRTN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PRTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRTN3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000840:  view genomic region     (about GC identifiers)

Start:
840,963 bp from pter      End:
848,175 bp from pter
Size:
7,213 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158 (See protein sequence)
Recommended Name: Myeloblastin precursor  
Size: 256 amino acids; 27807 Da
Sequence caution: Sequence=AAA36342.1; Type=Frameshift; Positions=34, 39; Sequence=CAA39598.1; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for PRTN3:
1FUJ (3D)    
Secondary accessions: P15637 P18078 Q4VB08 Q4VB09 Q6LBM7 Q6LBN2 Q9UD25 Q9UQD8

Explore the universe of human proteins at neXtProt for PRTN3: NX_P24158

Explore proteomics data for PRTN3 at MOPED 

4/5 DME Specific Peptides for PRTN3 (P24158) (see all 5)
 GDSGGPL  SGGPLIC  VLTAAHC  PHSRPYMA 

PRTN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

PRTN3 Protein Expression
REFSEQ proteins: NP_002768.3  
ENSEMBL proteins: 
 ENSP00000234347   ENSP00000475174  

Human Recombinant Protein Products for PRTN3: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Enzo Life Sciences proteins for PRTN3
OriGene Purified Protein for PRTN3
OriGene Protein Over-expression Lysate for PRTN3
OriGene MassSpec for PRTN3 
OriGene Custom Protein Services for PRTN3
GenScript Custom Purified and Recombinant Proteins Services for PRTN3
Novus Biologicals PRTN3 Proteins
Novus Biologicals PRTN3 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for PRTN3
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol IDA17712045
GO:0005886plasma membrane IDA17712045
GO:0031012colocalizes with extracellular matrix IDA--

PRTN3 for ontologies           About GeneDecksing



PRTN3 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)
OriGene Antibodies for PRTN3
OriGene Custom Antibody Services for PRTN3
GenScript Custom Superior Antibodies Services for PRTN3
Novus Biologicals PRTN3 Antibodies
Abcam antibodies for PRTN3
Browse Antibodies at Cloud-Clone Corp. 
ThermoFisher Antibody for PRTN3
LSBio Antibodies in human, mouse, rat for PRTN3 

Assay Products for PRTN3: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for PRTN3
R&D Systems Proteome Profiler Antibody Arrays for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)
GenScript Custom Assay Services for PRTN3
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P24158

ProtoNet protein and cluster: P24158

2 Blocks protein domains:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: PRTN3_HUMAN, P24158
Similarity: Belongs to the peptidase S1 family. Elastase subfamily
Similarity: Contains 1 peptidase S1 domain


PRTN3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PRTN3_HUMAN, P24158
Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin,
and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to
hamsters
Catalytic activity: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- -Xaa- > -Val- -Xaa-

     Genatlas biochemistry entry for PRTN3:
proteinase 3,myeloblastin,Wegener autoantigen,responsive to CSF3,stimulated by SPI1,MYB,inducing factor
independent growth of hematopoietic cells

     Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.761

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
GO:0005515protein binding ----
GO:0008236serine-type peptidase activity NAS--
GO:0019899enzyme binding IPI17712045
     
PRTN3 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for PRTN3:
 Decreased viability  Synthetic lethal with Ras 

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Prtn3):
 immune system 

PRTN3 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Elane/Prtn3Elane/tm1Deje for PRTN3

   inGenious Targeting Laboratory - Custom generated mouse model solutions for PRTN3 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRTN3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRTN3 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRTN3 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRTN3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PRTN3
SwitchGear 3'UTR luciferase reporter plasmidPRTN3 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for PRTN3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRTN3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for PRTN3
Sirion Biotech Customized adenovirus for overexpression of PRTN3

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for PRTN3 (see all 7)
OriGene ORF clones in mouse, rat for PRTN3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PRTN3 (NM_002777)
Sino Biological Human cDNA Clone for PRTN3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRTN3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3
Sirion Biotech Customized lentivirus for stable overexpression of PRTN3 
                     Customized lentivirus expression plasmids for stable overexpression of PRTN3 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for PRTN3
Search LifeMap BioReagents cell lines for PRTN3
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for PRTN3 About                                                                                                See pathways by source

SuperPathContained pathways About
1C-MYB transcription factor network
C-MYB transcription factor network


1 BioSystems Pathway for PRTN3
    C-MYB transcription factor network



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRTN3

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

53/58 Interacting proteins for PRTN3 (P241581, 2, 3 ENSP000002343474) via UniProtKB, MINT, STRING, and/or I2D (see all 58) (see top 5)
InteractantInteraction Details
GeneCardExternal ID(s)
SMAD3P840221, 3, ENSP000003329734EBI-465028,EBI-347161 I2D: score=3 STRING: ENSP00000332973
TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
ENSG00000204490P013753I2D: score=1 
ENSG00000206439P013753I2D: score=1 
ENSG00000223952P013753I2D: score=1 
ENSG00000228321P013753I2D: score=1 
ENSG00000228849P013753I2D: score=1 
ENSG00000230108P013753I2D: score=1 
SERPINA1P010093, ENSP000003480684I2D: score=2 STRING: ENSP00000348068
CAMPP499133, ENSP000002964354I2D: score=1 STRING: ENSP00000296435
F2RL1P550853, ENSP000002966774I2D: score=1 STRING: ENSP00000296677
IL32P240013, ENSP000003247424I2D: score=1 STRING: ENSP00000324742
ITGB2P051073, ENSP000003032424I2D: score=1 STRING: ENSP00000303242
SERPINB1P307403, ENSP000003701154I2D: score=3 STRING: ENSP00000370115
ELNP155023, ENSP000002520344I2D: score=2 STRING: ENSP00000252034
IL1BP015843, ENSP000002633414I2D: score=1 STRING: ENSP00000263341
ITGAMP112153, ENSP000002874974I2D: score=1 STRING: ENSP00000287497
RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
F2RP251163, ENSP000003213264I2D: score=1 STRING: ENSP00000321326
SERPINB13Q9UIV83, ENSP000003415844I2D: score=1 STRING: ENSP00000341584
ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
A2MP010232MINT-4054731
ACTBP607092MINT-4054731
ALPPP051872MINT-4054731
APODP050902MINT-4054731
ARL8BQ9NVJ22MINT-4054731
ASAH1Q135102MINT-4054731
ATP5A1P257052MINT-4054731
ATP5BP065762MINT-4054731
ATP6V0D1P614212MINT-4054731
ATP6V1AP386062MINT-4054731
AZU1P201602MINT-4054731
CAPN6Q9Y6Q12MINT-4054731
CKMT1AP125322MINT-4054731
CKMT1BP125322MINT-4054731
CTSGP083112MINT-4054731
CYP11A1P051082MINT-4054731
CYP19A1P115112MINT-4054731
DDOSTP396562MINT-4054731
DLSTP369572MINT-4054731
GAPDHP044062MINT-4054731
GBAP040622MINT-4054731
GLB1P162782MINT-4054731
GUSBP082362MINT-4054731
HSPA5P110212MINT-4054731
HSPD1P108092MINT-4054731
MAOAP213972MINT-4054731
MPOP051642MINT-4054731
SCARB2Q141082MINT-4054731
SLC25A5P051412MINT-4054731
SLC25A6P122362MINT-4054731
STSP088422MINT-4054731
TPP1O147732MINT-4054731
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--
GO:0008284positive regulation of cell proliferation TAS2598267
GO:0030574collagen catabolic process IEA--
GO:0050765negative regulation of phagocytosis IDA17712045
GO:0097029mature dendritic cell differentiation IDA16478888

PRTN3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PRTN3 for compounds           About GeneDecksing

EMD Millipore small molecules for PRTN3:
Small Molecule - inhibitor
Enzo Life Sciences drugs & compounds for PRTN3

Browse Tocris compounds for PRTN3

10/44 Novoseek inferred chemical compound relationships for PRTN3 gene (see all 44)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
serine 75.5 224 2033050 (4), 1400430 (3), 11272267 (3), 1681549 (3) (see all 99)
propylthiouracil 63.2 5 10025935 (1), 8103148 (1), 17350787 (1), 17161817 (1)
acpa 58.3 5 1316247 (1), 2240162 (1), 1656761 (1), 1688612 (1)
sulf 55.6 3 7586784 (1), 7612152 (1)
aebsf 53.6 1 12354776 (1)
3,4-dichloroisocoumarin 50.6 4 14525961 (1), 9067256 (1), 1551417 (1)
pmsf 40.3 5 12960243 (1), 8033421 (1), 9500517 (1)
fmlp 32.9 1 10498622 (1)
phthalimide 32.6 4 7796053 (2), 8806743 (2)
n-formylmethionyl-leucylphenylalanine 29.6 1 10614782 (1)

Search CenterWatch for drugs/clinical trials and news about PRTN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRTN3 gene: 
NM_002777.3  

Unigene Cluster for PRTN3:

Proteinase 3
Hs.928  [show with all ESTs]
Unigene Representative Sequence: FN647680
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000234347(uc002lqa.1) ENST00000544537(uc021umb.1)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRTN3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PRTN3
SwitchGear 3'UTR luciferase reporter plasmidPRTN3 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for PRTN3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRTN3
Clone
Products:
     
OriGene clones in human, mouse for PRTN3 (see all 7)
OriGene ORF clones in mouse, rat for PRTN3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PRTN3 (NM_002777)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRTN3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3
Sirion Biotech Customized lentivirus for stable overexpression of PRTN3 
                     Customized lentivirus expression plasmids for stable overexpression of PRTN3 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for PRTN3
OriGene qSTAR qPCR primer pairs in human, mouse for PRTN3
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRTN3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRTN3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRTN3

Additional mRNA sequence: 

BC096183.1 BC096184.3 BC096185.3 BC096186.3 FN647680.1 M29142.1 M75154.1 X55668.1 
X56132.1 X56606.1 

1 DOTS entry:

DT.310571 

24/27 AceView cDNA sequences (see all 27):

BV199984 BI029214 X56606 BV199995 X56132 BV185512 BI029018 BV199994 
BP428518 BP429701 AI273534 M29142 BP428468 NM_002777 X55668 BF893078 
M75154 BE831590 BF898648 AW966814 BQ335282 BI026807 BI028421 T85543 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRTN3 expression in normal human tissues (normalized intensities)      PRTN3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
PRTN3 Expression
About this image


PRTN3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 7 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
         Bone marrow-derived hematopoietic stem cells
         Bone Marrow CD34+ Cells   
         bone marrow mononuclear cells   
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone Marrow
         bone marrow   
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 Liver (Hepatobiliary System)
         Fetal Liver CD34+ Cells   

See PRTN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRTN3

SOURCE GeneReport for Unigene cluster: Hs.928
    SABiosciences Expression via Pathway-Focused PCR Array including PRTN3: 
          Antibacterial Response in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for PRTN3
OriGene qSTAR qPCR primer pairs in human, mouse for PRTN3
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRTN3
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRTN3
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRTN3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PRTN3 gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Prtn31 , 5 proteinase 31, 5 70.92(n)1
65.74(a)1
  10 (39.72 cM)5
191521  NM_011178.21  NP_035308.21 
 798744765 
zebrafish
(Danio rerio)
Actinopterygii si:dkey-21e2.106
si:dkey-21e2.76
(see all 25)
si:dkey-21e2.7
(see all 25)
34(a)
34(a)
(see all 25)
possible ortholog
possible ortholog
(see all 25)
22(19565584-19569063)
22(19537137-19539386)
fruit fly
(Drosophila melanogaster)
Insecta CG328086
CG167496
(see all 3)
--
28(a)
28(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
X(1362763-1363679)
3R(5156607-5157617)


ENSEMBL Gene Tree for PRTN3 (if available)
TreeFam Gene Tree for PRTN3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for PRTN3 gene
GZMH2  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  AZU12  
GZMM2  GZMA2  GZMB2  
18/53 SIMAP similar genes for PRTN3 using alignment to 2 protein entries:     PRTN3_HUMAN (see all proteins) (see all similar genes):
ELANE    ELA2    AZU1    PRSS1    CTSG    CMA1
PRSS2    TRY6    TRY8    PRSS3    CTRL    GZMK
KLK4    DF    LPA    CFD    APS    KLK6

PRTN3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/334 SNPs in PRTN3 are shown (see all 334)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1492124241,2
--839030(+) ATGGGC/TTTCGA 1 -- us2k10--------
rs1432557671,2
--839070(+) CGCCCA/GGGACT 1 -- us2k10--------
rs739198631,2
C,F--839097(+) GAGGCC/AACCCA 1 -- us2k13Minor allele frequency- A:0.07WA CSA 122
rs1482964801,2
C--839147(+) CAGCTC/GTCCTC 1 -- us2k10--------
rs120521081,2
C,F,A,H--839158(+) AATGGC/TCCCAA 1 -- us2k122Minor allele frequency- T:0.18NS EA NA WA CSA 2347
rs1405230041,2
--839189(+) GACTGA/CGCCCG 1 -- us2k10--------
rs793612211,2
F--839193(+) GCGCCC/GGCTGG 1 -- us2k10--------
rs1380321111,2
--839269(+) ATACTC/TAGGGG 1 -- us2k10--------
rs104108261,2
C,F--839272(+) CTCAGG/TGGGCT 1 -- us2k14Minor allele frequency- T:0.23NA WA CSA 124
rs621322941,2
C,F--839298(+) ATTTGG/CAATCA 1 -- us2k13Minor allele frequency- C:0.18NA EA 242

HapMap Linkage Disequilibrium report for PRTN3 (840963 - 848175 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/21 variations for PRTN3 (see all 21):    About this table     
Variant IDTypeSubtypePubMed ID
esv2717797CNV Deletion23290073
esv2717798CNV Deletion23290073
nsv470101CNV Loss18288195
dgv3550n71CNV Loss21882294
nsv910292CNV Loss21882294
nsv138320CNV Loss16902084
dgv3558n71CNV Loss21882294
dgv3555n71CNV Loss21882294
dgv3552n71CNV Loss21882294
dgv3554n71CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing PRTN3
DNA2.0 Custom Variant and Variant Library Synthesis for PRTN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 177020    OMIM disorders: --

20/87 diseases for PRTN3 (see all 87):    About MalaCards
wegener's granulomatosis    subacute bacterial endocarditis    mononeuritis multiplex    mononeuritis
mononeuropathy    rapidly progressive glomerulonephritis    alpha 1-antitrypsin deficiency    endocarditis
scleritis    vasculitis    crescentic glomerulonephritis    churg-strauss syndrome
mixed connective tissue disease    relapsing polychondritis    polyarteritis nodosa    microscopic polyangiitis
cholangitis    glomerulonephritis    pyoderma    pyoderma gangrenosum

12 diseases from the University of Copenhagen DISEASES database for PRTN3:
Vasculitis     Hypersensitivity reaction type II disease     Glomerulonephritis     Rheumatoid arthritis
Polyarteritis nodosa     Scleritis     Sinusitis     Connective tissue disease
Endocarditis     Ulcerative colitis     Lung disease     Mononeuropathy

PRTN3 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/81 Novoseek inferred disease relationships for PRTN3 gene (see all 81)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
wegeners granulomatosis 96.5 304 8157982 (3), 15498036 (3), 17005932 (3), 19881350 (3) (see all 99)
vasculitis 92.8 228 12605707 (4), 16792675 (4), 15958084 (3), 8499060 (2) (see all 99)
churg-strauss syndrome 85.5 15 12687504 (1), 17521322 (1), 10896971 (1), 8381764 (1) (see all 10)
glomerulonephritis 81.1 20 10405206 (2), 10844589 (1), 11034396 (1), 11092351 (1) (see all 14)
glomerulonephritis rapidly progressive 78.9 2 7847352 (1), 9306336 (1)
vasculitis leukocytoclastic 71.9 8 7626983 (1), 7554378 (1), 11838849 (1), 11208991 (1) (see all 6)
polyarteritis nodosa 64.4 6 7754755 (2), 7907475 (1)
pulmonary hemorrhage 57.2 1 1351955 (1)
inflammation 55.5 43 10101005 (2), 7829874 (1), 10471824 (1), 11272269 (1) (see all 28)
autoimmune diseases 55.2 8 14736010 (1), 10720938 (1), 16026591 (1), 18953353 (1) (see all 7)

Genetic Association Database (GAD): PRTN3
Human Genome Epidemiology (HuGE) Navigator: PRTN3 (7 documents)

Export disorders for PRTN3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for PRTN3 gene, integrated from 9 sources (see all 667):
(articles sorted by number of sources associating them with PRTN3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. (PubMed id 2258701)1, 2, 3, 9 Campanelli D....Gabay J.E. (1990)
  2. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. (PubMed id 2033050)1, 2, 9 Rao N.V....Hoidal J.R. (1991)
  3. Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. (PubMed id 1400430)1, 2, 9 Sturrock A.B.... Hoidal J.R. (1992)
  4. Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism. (PubMed id 16792675)1, 4, 9 Abdgawad M....Segelmark M. (2006)
  5. Proteinase 3 gene polymorphisms and Wegener's granulomatosis. (PubMed id 11115080)1, 4, 9 Gencik M....Fricke H. (2000)
  6. Wegener autoantigen and myeloblastin are encoded by a single mRNA. (PubMed id 1681549)1, 2, 9 Labbaye C.... Cayre Y.E. (1991)
  7. Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme. (PubMed id 2121162)1, 2, 9 Ohlsson K.... Rosengren M. (1990)
  8. The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. (PubMed id 8757293)1, 2, 9 Fujinaga M.... James M.N.G. (1996)
  9. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PubMed id 1518849)1, 2, 9 Zimmer M....Jenne D.E. (1992)
  10. Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia. (PubMed id 9924693)1, 2, 9 Clave E.... Barrett A.J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 5657 HGNC: 9495 AceView: PRTN3 Ensembl:ENSG00000196415 euGenes: HUgn5657
ECgene: PRTN3 H-InvDB: PRTN3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for PRTN3 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Proteinase_3

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for PRTN3 gene:
Search GeneIP for patents involving PRTN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
 EMD Millipore small molecules (inhibitor) for PRTN3
 Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
 Browse Purified and Recombinant Proteins at EMD Millipore
 Browse for Gene Knock-down Tools from EMD Millipore
 Browse Kits and Assays available from EMD Millipore
 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Proteome Profiler Antibody Arrays for PRTN3 (Proteinase 3/Myeloblastin/PRTN3)  
 OriGene Antibodies for PRTN3   OriGene RNAi products in human, mouse, rat for PRTN3  
 OriGene qPCR primer pairs and template standards for PRTN3   OriGene Protein Over-expression Lysate for PRTN3  
 OriGene MassSpec something-or-other for PRTN3   OriGene clones in human, mouse for PRTN3  
 OriGene qSTAR qPCR primer pairs in human, mouse for PRTN3   OriGene Purified Protein for PRTN3  
 OriGene ORF clones in mouse, rat for PRTN3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for PRTN3   OriGene Custom Protein Services for PRTN3  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRTN3
 QIAGEN SeqTarget long-range PCR primers for resequencing PRTN3
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRTN3
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRTN3
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRTN3
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRTN3
 GenScript Custom Purified and Recombinant Proteins Services for PRTN3 GenScript cDNA clones with any tag delivered in your preferred vector for PRTN3
 GenScript Custom Assay Services for PRTN3 GenScript Custom Superior Antibodies Services for PRTN3
 GenScript Custom overexpressing Cell Line Services for PRTN3 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in PRTN3 promoter
 Search Chromatin IP Primers for PRTN3
 RT2 qPCR Primer Assay in human, mouse, rat PRTN3
 GNC Network for PRTN3
 SABiosciences PCR Arrays including human, mouse, rat PRTN3
 Search Tocris compounds for PRTN3
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 cDNA Clones for PRTN3
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Drugs/Proteins for PRTN3
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 PRTN3 antibodies
 PRTN3 proteins
 PRTN3 lysates
 Antibodies for PRTN3
 See all of Abcam's Antibodies, Kits and Proteins for PRTN3
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for PRTN3




 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for PRTN3
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRTN3
 SwitchGear 3'UTR luciferase reporter plasmids for PRTN3
 SwitchGear Promoter luciferase reporter plasmids for PRTN3
 ThermoFisher Antibody for PRTN3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRTN3
 inGenious Targeting Laboratory - Custom generated mouse model solutions for PRTN3
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRTN3
Customized:
 lentivirus for stable overexpression of PRTN3
 lentivirus expression plasmids for stable overexpression of PRTN3
 adenovirus for overexpression of PRTN3
 LSBio Antibodies in human, mouse, rat for PRTN3
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      PRTN3 gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4