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Aliases for PRTG Gene

Aliases for PRTG Gene

  • Protogenin 2 3
  • Protogenin Homolog (Gallus Gallus) 2 3
  • Immunoglobulin Superfamily, DCC Subclass, Member 5 3
  • Immunoglobulin Superfamily 2
  • Protein Shen-Dan 4
  • DCC Subclass 2
  • Member 5 2
  • Shen-Dan 3
  • IGDCC5 3

External Ids for PRTG Gene

Summaries for PRTG Gene

Entrez Gene Summary for PRTG Gene

  • This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]

GeneCards Summary for PRTG Gene

PRTG (Protogenin) is a Protein Coding gene. Among its related pathways are Neural Crest Differentiation. An important paralog of this gene is ROBO1.

UniProtKB/Swiss-Prot for PRTG Gene

  • May play a role in anteroposterior axis elongation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRTG Gene

Genomics for PRTG Gene

Genomic Location for PRTG Gene

55,611,540 bp from pter
55,743,649 bp from pter
132,110 bases
Minus strand

Genomic View for PRTG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRTG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRTG Gene

Regulatory Elements for PRTG Gene

Proteins for PRTG Gene

  • Protein details for PRTG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8N7D8

    Protein attributes for PRTG Gene

    1150 amino acids
    Molecular mass:
    127076 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05355.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PRTG Gene

Proteomics data for PRTG Gene at MOPED

Post-translational modifications for PRTG Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn90, Asn488, Asn630, and Asn986

Other Protein References for PRTG Gene

No data available for DME Specific Peptides for PRTG Gene

Domains for PRTG Gene

Gene Families for PRTG Gene

  • ISET :Immunoglobulin superfamily / I-set domain containing
  • FN3 :Fibronectin type III domain containing

Protein Domains for PRTG Gene


  • Contains 5 fibronectin type-III domains.:
    • Q2VWP7
  • Contains 4 Ig-like (immunoglobulin-like) domains.:
    • Q2VWP7
  • Belongs to the immunoglobulin superfamily. DCC family.:
    • Q2VWP7
genes like me logo Genes that share domains with PRTG: view

Function for PRTG Gene

Molecular function for PRTG Gene

UniProtKB/Swiss-Prot Function: May play a role in anteroposterior axis elongation.

Gene Ontology (GO) - Molecular Function for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PRTG: view

miRNA for PRTG Gene

miRTarBase miRNAs that target PRTG

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRTG Gene

Localization for PRTG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRTG Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PRTG Gene COMPARTMENTS Subcellular localization image for PRTG gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRTG: view

Pathways for PRTG Gene

SuperPathways for PRTG Gene

genes like me logo Genes that share pathways with PRTG: view

Pathways by source for PRTG Gene

1 BioSystems pathway for PRTG Gene

Interacting Proteins for PRTG Gene

Gene Ontology (GO) - Biological Process for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with PRTG: view

Transcripts for PRTG Gene

mRNA/cDNA for PRTG Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRTG Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRTG Gene

No ASD Table

Relevant External Links for PRTG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRTG Gene

mRNA expression in normal human tissues for PRTG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRTG Gene

This gene is overexpressed in Thyroid (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRTG Gene

SOURCE GeneReport for Unigene cluster for PRTG Gene Hs.130957

genes like me logo Genes that share expressions with PRTG: view

Orthologs for PRTG Gene

This gene was present in the common ancestor of animals.

Orthologs for PRTG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRTG 36
  • 99.59 (n)
  • 99.74 (a)
  • 100 (a)
(Bos Taurus)
Mammalia PRTG 36
  • 91.17 (n)
  • 94.07 (a)
  • 90 (a)
(Canis familiaris)
Mammalia PRTG 36
  • 93.04 (n)
  • 96.24 (a)
  • 91 (a)
(Mus musculus)
Mammalia Prtg 36
  • 84.82 (n)
  • 91.1 (a)
Prtg 16
Prtg 37
  • 87 (a)
(Monodelphis domestica)
Mammalia PRTG 37
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia PRTG 37
  • 84 (a)
(Rattus norvegicus)
Mammalia Prtg 36
  • 84.46 (n)
  • 91.01 (a)
(Gallus gallus)
Aves PRTG 36
  • 79.62 (n)
  • 85.94 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia PRTG 37
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prtg 36
  • 71.68 (n)
  • 71.95 (a)
(Danio rerio)
Actinopterygii PRTG (2 of 2) 37
  • 53 (a)
prtga 36
  • 63.07 (n)
  • 64.29 (a)
prtgb 37
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cont 37
  • 14 (a)
Species with no ortholog for PRTG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRTG Gene

Gene Tree for PRTG (if available)
Gene Tree for PRTG (if available)

Paralogs for PRTG Gene

Selected SIMAP similar genes for PRTG Gene using alignment to 4 proteins: Pseudogenes for PRTG Gene

genes like me logo Genes that share paralogs with PRTG: view

Variants for PRTG Gene

Sequence variations from dbSNP and Humsavar for PRTG Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs489672 -- 55,638,379(+) AAATA(A/T)AATAA intron-variant
rs490012 -- 55,629,375(+) TATAT(A/G)TGTGT intron-variant
rs491014 -- 55,616,005(-) TGGGA(A/G)CAATG utr-variant-3-prime, nc-transcript-variant
rs492363 -- 55,651,344(-) CCTAA(C/T)GTTTA intron-variant
rs495381 -- 55,681,200(+) TTCAA(A/T)CATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRTG Gene

Variant ID Type Subtype PubMed ID
nsv457158 CNV Loss 19166990
nsv833017 CNV Loss 17160897

Relevant External Links for PRTG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for PRTG Gene

Relevant External Links for PRTG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PRTG: view

No data available for UniProtKB/Swiss-Prot for PRTG Gene

Publications for PRTG Gene

  1. Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region. (PMID: 19076634) Wigg K.G. … Barr C.L. (Genes Brain Behav. 2008) 3 23 49
  2. Identification of protogenin, a novel immunoglobulin superfamily gene expressed during early chick embryogenesis. (PMID: 15922677) Toyoda R. … Watanabe Y. (Gene Expr. Patterns 2005) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  5. Nuclear translocation of intracellular domain of Protogenin by proteolytic cleavage. (PMID: 22150322) Watanabe Y. … Nakamura H. (Dev. Growth Differ. 2012) 3

Products for PRTG Gene

Sources for PRTG Gene

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