Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRTG Gene

Aliases for PRTG Gene

  • Protogenin 2 3
  • Protogenin Homolog (Gallus Gallus) 2 3
  • Immunoglobulin Superfamily, DCC Subclass, Member 5 3
  • Immunoglobulin Superfamily 2
  • Protein Shen-Dan 4
  • DCC Subclass 2
  • Member 5 2
  • Shen-Dan 3
  • IGDCC5 3

External Ids for PRTG Gene

Previous GeneCards Identifiers for PRTG Gene

  • GC15M053700
  • GC15M055903
  • GC15M032727

Summaries for PRTG Gene

Entrez Gene Summary for PRTG Gene

  • This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]

GeneCards Summary for PRTG Gene

PRTG (Protogenin) is a Protein Coding gene. Among its related pathways are Neural Crest Differentiation. An important paralog of this gene is ROBO1.

UniProtKB/Swiss-Prot for PRTG Gene

  • May play a role in anteroposterior axis elongation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRTG Gene

Genomics for PRTG Gene

Regulatory Elements for PRTG Gene

Genomic Location for PRTG Gene

Start:
55,611,540 bp from pter
End:
55,743,649 bp from pter
Size:
132,110 bases
Orientation:
Minus strand

Genomic View for PRTG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRTG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRTG Gene

Proteins for PRTG Gene

  • Protein details for PRTG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VWP7-PRTG_HUMAN
    Recommended name:
    Protogenin
    Protein Accession:
    Q2VWP7
    Secondary Accessions:
    • Q8N7D8

    Protein attributes for PRTG Gene

    Size:
    1150 amino acids
    Molecular mass:
    127076 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05355.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PRTG Gene

Proteomics data for PRTG Gene at MOPED

Post-translational modifications for PRTG Gene

  • Glycosylation at Asn90, Asn488, Asn630, and Asn986
  • Modification sites at PhosphoSitePlus

Other Protein References for PRTG Gene

No data available for DME Specific Peptides for PRTG Gene

Domains for PRTG Gene

Gene Families for PRTG Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Protein Domains for PRTG Gene

Suggested Antigen Peptide Sequences for PRTG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2VWP7

UniProtKB/Swiss-Prot:

PRTG_HUMAN :
  • Q2VWP7
Domain:
  • Contains 5 fibronectin type-III domains.
  • Contains 4 Ig-like (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with PRTG: view

Function for PRTG Gene

Molecular function for PRTG Gene

UniProtKB/Swiss-Prot Function: May play a role in anteroposterior axis elongation.

Gene Ontology (GO) - Molecular Function for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PRTG: view

Animal Model Products

miRNA for PRTG Gene

miRTarBase miRNAs that target PRTG

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRTG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRTG Gene

Localization for PRTG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRTG Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRTG Gene COMPARTMENTS Subcellular localization image for PRTG gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRTG: view

Pathways for PRTG Gene

SuperPathways for PRTG Gene

genes like me logo Genes that share pathways with PRTG: view

Pathways by source for PRTG Gene

1 BioSystems pathway for PRTG Gene

Interacting Proteins for PRTG Gene

Gene Ontology (GO) - Biological Process for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with PRTG: view

Transcripts for PRTG Gene

mRNA/cDNA for PRTG Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRTG Gene

Protogenin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRTG

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PRTG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRTG Gene

No ASD Table

Relevant External Links for PRTG Gene

GeneLoc Exon Structure for
PRTG
ECgene alternative splicing isoforms for
PRTG

Expression for PRTG Gene

mRNA expression in normal human tissues for PRTG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRTG Gene

This gene is overexpressed in Thyroid (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRTG Gene

SOURCE GeneReport for Unigene cluster for PRTG Gene Hs.130957

genes like me logo Genes that share expressions with PRTG: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PRTG Gene

Orthologs for PRTG Gene

This gene was present in the common ancestor of animals.

Orthologs for PRTG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRTG 35
  • 99.59 (n)
  • 99.74 (a)
PRTG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRTG 35
  • 91.17 (n)
  • 94.07 (a)
PRTG 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRTG 35
  • 93.04 (n)
  • 96.24 (a)
PRTG 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prtg 35
  • 84.82 (n)
  • 91.1 (a)
Prtg 16
Prtg 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRTG 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRTG 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prtg 35
  • 84.46 (n)
  • 91.01 (a)
chicken
(Gallus gallus)
Aves PRTG 35
  • 79.62 (n)
  • 85.94 (a)
PRTG 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRTG 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prtg 35
  • 71.68 (n)
  • 71.95 (a)
zebrafish
(Danio rerio)
Actinopterygii PRTG (2 of 2) 36
  • 53 (a)
OneToMany
prtga 35
  • 63.07 (n)
  • 64.29 (a)
prtgb 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cont 36
  • 14 (a)
OneToMany
Species with no ortholog for PRTG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRTG Gene

ENSEMBL:
Gene Tree for PRTG (if available)
TreeFam:
Gene Tree for PRTG (if available)

Paralogs for PRTG Gene

Selected SIMAP similar genes for PRTG Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PRTG Gene

genes like me logo Genes that share paralogs with PRTG: view

Variants for PRTG Gene

Sequence variations from dbSNP and Humsavar for PRTG Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs489672 -- 55,638,379(+) AAATA(A/T)AATAA intron-variant
rs490012 -- 55,629,375(+) TATAT(A/G)TGTGT intron-variant
rs491014 -- 55,616,005(-) TGGGA(A/G)CAATG utr-variant-3-prime, nc-transcript-variant
rs492363 -- 55,651,344(-) CCTAA(C/T)GTTTA intron-variant
rs495381 -- 55,681,200(+) TTCAA(A/T)CATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRTG Gene

Variant ID Type Subtype PubMed ID
nsv457158 CNV Loss 19166990
nsv833017 CNV Loss 17160897

Relevant External Links for PRTG Gene

HapMap Linkage Disequilibrium report
PRTG
Human Gene Mutation Database (HGMD)
PRTG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRTG Gene

Disorders for PRTG Gene

Relevant External Links for PRTG

Genetic Association Database (GAD)
PRTG
Human Genome Epidemiology (HuGE) Navigator
PRTG
genes like me logo Genes that share disorders with PRTG: view

No data available for UniProtKB/Swiss-Prot for PRTG Gene

Publications for PRTG Gene

  1. Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region. (PMID: 19076634) Wigg K.G. … Barr C.L. (Genes Brain Behav. 2008) 3 23 48
  2. Identification of protogenin, a novel immunoglobulin superfamily gene expressed during early chick embryogenesis. (PMID: 15922677) Toyoda R. … Watanabe Y. (Gene Expr. Patterns 2005) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  5. Nuclear translocation of intracellular domain of Protogenin by proteolytic cleavage. (PMID: 22150322) Watanabe Y. … Nakamura H. (Dev. Growth Differ. 2012) 3

Products for PRTG Gene

Sources for PRTG Gene

Back to Top

Content