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Aliases for PRTG Gene

Aliases for PRTG Gene

  • Protogenin 2 3 3 5
  • Immunoglobulin Superfamily, DCC Subclass, Member 5 2 3
  • Protogenin Homolog (Gallus Gallus) 2 3
  • Protein Shen-Dan 4
  • Shen-Dan 3
  • IGDCC5 3

External Ids for PRTG Gene

Previous GeneCards Identifiers for PRTG Gene

  • GC15M053700
  • GC15M055903
  • GC15M032727

Summaries for PRTG Gene

Entrez Gene Summary for PRTG Gene

  • This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]

GeneCards Summary for PRTG Gene

PRTG (Protogenin) is a Protein Coding gene. Diseases associated with PRTG include Attention Deficit-Hyperactivity Disorder. Among its related pathways are Neural Crest Differentiation. An important paralog of this gene is IGDCC4.

UniProtKB/Swiss-Prot for PRTG Gene

  • May play a role in anteroposterior axis elongation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRTG Gene

Genomics for PRTG Gene

Regulatory Elements for PRTG Gene

Enhancers for PRTG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F055627 1.1 Ensembl ENCODE 20.6 +115.5 115548 1.6 GTF2F1 CTCF MXI1 PKNOX1 JUN MAX BRCA1 RFX5 HIC1 ZBTB48 PRTG PYGO1 ENSG00000259180
GH15F055894 1 Ensembl ENCODE 20 -151.4 -151354 1.6 SOX13 TBP ATF1 SAP130 ZNF384 CEBPG ZBTB40 CREM SOX5 HLF PRTG NEDD4 GC15P055749
GH15F055661 0.9 Ensembl ENCODE 21.6 +81.9 81929 1.3 SOX13 SCRT1 PKNOX1 NR2F1 FEZF1 ZIC2 SCRT2 NR2F6 HOMEZ PRTG ENSG00000259180 PYGO1
GH15F055768 0.5 ENCODE 35.3 -25.2 -25232 1.0 ESRRA DPF2 FOS PRTG PYGO1 GC15P055749 NEDD4
GH15F055912 0.9 ENCODE 19.1 -172.1 -172096 6.3 TBP ZNF133 FEZF1 BRCA1 RAD21 RFX5 RCOR1 ETV6 FOS ZNF654 PRTG NEDD4 GC15P055749
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRTG on UCSC Golden Path with GeneCards custom track

Promoters for PRTG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000408298 1049 2801 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 BRCA1 ZNF121

Genomic Location for PRTG Gene

Chromosome:
15
Start:
55,611,540 bp from pter
End:
55,743,649 bp from pter
Size:
132,110 bases
Orientation:
Minus strand

Genomic View for PRTG Gene

Genes around PRTG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRTG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRTG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRTG Gene

Proteins for PRTG Gene

  • Protein details for PRTG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VWP7-PRTG_HUMAN
    Recommended name:
    Protogenin
    Protein Accession:
    Q2VWP7
    Secondary Accessions:
    • Q8N7D8

    Protein attributes for PRTG Gene

    Size:
    1150 amino acids
    Molecular mass:
    127076 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05355.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PRTG Gene

Post-translational modifications for PRTG Gene

  • Glycosylation at Asn 90, Asn 488, and Asn 630
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRTG Gene

Domains & Families for PRTG Gene

Suggested Antigen Peptide Sequences for PRTG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2VWP7

UniProtKB/Swiss-Prot:

PRTG_HUMAN :
  • Contains 5 fibronectin type-III domains.
  • Belongs to the immunoglobulin superfamily. DCC family.
Domain:
  • Contains 5 fibronectin type-III domains.
  • Contains 4 Ig-like (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with PRTG: view

Function for PRTG Gene

Molecular function for PRTG Gene

UniProtKB/Swiss-Prot Function:
May play a role in anteroposterior axis elongation.
genes like me logo Genes that share phenotypes with PRTG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRTG

miRNA for PRTG Gene

miRTarBase miRNAs that target PRTG

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRTG Gene

Localization for PRTG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRTG Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRTG gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRTG: view

Pathways & Interactions for PRTG Gene

SuperPathway Contained pathways
1 Neural Crest Differentiation
genes like me logo Genes that share pathways with PRTG: view

Pathways by source for PRTG Gene

1 BioSystems pathway for PRTG Gene

Interacting Proteins for PRTG Gene

Gene Ontology (GO) - Biological Process for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with PRTG: view

No data available for SIGNOR curated interactions for PRTG Gene

Transcripts for PRTG Gene

mRNA/cDNA for PRTG Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRTG Gene

Protogenin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRTG Gene

No ASD Table

Relevant External Links for PRTG Gene

GeneLoc Exon Structure for
PRTG
ECgene alternative splicing isoforms for
PRTG

Expression for PRTG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRTG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRTG Gene

This gene is overexpressed in Thyroid (x11.5).

Protein differential expression in normal tissues from HIPED for PRTG Gene

This gene is overexpressed in Pancreatic juice (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRTG Gene



Protein tissue co-expression partners for PRTG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRTG Gene:

PRTG

SOURCE GeneReport for Unigene cluster for PRTG Gene:

Hs.130957
genes like me logo Genes that share expression patterns with PRTG: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PRTG Gene

Orthologs for PRTG Gene

This gene was present in the common ancestor of animals.

Orthologs for PRTG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRTG 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia PRTG 34 35
  • 93.04 (n)
cow
(Bos Taurus)
Mammalia PRTG 34 35
  • 91.17 (n)
oppossum
(Monodelphis domestica)
Mammalia PRTG 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prtg 34 16 35
  • 84.82 (n)
rat
(Rattus norvegicus)
Mammalia Prtg 34
  • 84.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRTG 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRTG 34 35
  • 79.62 (n)
lizard
(Anolis carolinensis)
Reptilia PRTG 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prtg 34
  • 71.68 (n)
zebrafish
(Danio rerio)
Actinopterygii prtga 34
  • 63.07 (n)
prtgb 35
  • 57 (a)
OneToMany
PRTG (2 of 2) 35
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cont 35
  • 14 (a)
OneToMany
Species where no ortholog for PRTG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRTG Gene

ENSEMBL:
Gene Tree for PRTG (if available)
TreeFam:
Gene Tree for PRTG (if available)

Paralogs for PRTG Gene

Paralogs for PRTG Gene

(11) SIMAP similar genes for PRTG Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PRTG Gene

genes like me logo Genes that share paralogs with PRTG: view

Variants for PRTG Gene

Sequence variations from dbSNP and Humsavar for PRTG Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1011061 -- 55,695,300(-) AATCG(C/T)GTATT intron-variant
rs1011741 -- 55,729,598(-) TTATT(A/T)TATTT intron-variant
rs1011992 -- 55,690,708(+) aggaa(C/T)aatca intron-variant
rs1014551 -- 55,690,059(-) ACTGT(A/G)TATCT intron-variant
rs10152116 -- 55,740,321(+) ATAAA(A/G)CAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRTG Gene

Variant ID Type Subtype PubMed ID
nsv833017 CNV loss 17160897
nsv569541 CNV loss 21841781
nsv569540 CNV gain 21841781
nsv569539 CNV loss 21841781
nsv457158 CNV loss 19166990
nsv1052495 CNV gain 25217958
nsv1043789 CNV gain 25217958
esv3636569 CNV gain 21293372
esv3636567 CNV loss 21293372
esv3581712 CNV loss 25503493
esv3581711 CNV loss 25503493
esv3569609 CNV gain 25503493
esv2761899 CNV gain+loss 21179565

Variation tolerance for PRTG Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.43; 81.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRTG Gene

Human Gene Mutation Database (HGMD)
PRTG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRTG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRTG Gene

Disorders for PRTG Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRTG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards
Search PRTG in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRTG

Genetic Association Database (GAD)
PRTG
Human Genome Epidemiology (HuGE) Navigator
PRTG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRTG
genes like me logo Genes that share disorders with PRTG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRTG Gene

Publications for PRTG Gene

  1. Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region. (PMID: 19076634) Wigg K.G. … Barr C.L. (Genes Brain Behav. 2008) 3 22 46 64
  2. Identification of protogenin, a novel immunoglobulin superfamily gene expressed during early chick embryogenesis. (PMID: 15922677) Toyoda R. … Watanabe Y. (Gene Expr. Patterns 2005) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin. (PMID: 24007463) Song J. … Jin E.J. (Cell Commun. Signal 2013) 3 64
  5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3 64

Products for PRTG Gene

Sources for PRTG Gene

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