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Aliases for PRTG Gene

Aliases for PRTG Gene

  • Protogenin 2 3 3 5
  • Immunoglobulin Superfamily, DCC Subclass, Member 5 2 3
  • Protogenin Homolog (Gallus Gallus) 2 3
  • Protein Shen-Dan 4
  • Shen-Dan 3
  • IGDCC5 3

External Ids for PRTG Gene

Previous GeneCards Identifiers for PRTG Gene

  • GC15M053700
  • GC15M055903
  • GC15M032727

Summaries for PRTG Gene

Entrez Gene Summary for PRTG Gene

  • This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]

GeneCards Summary for PRTG Gene

PRTG (Protogenin) is a Protein Coding gene. Diseases associated with PRTG include Attention Deficit-Hyperactivity Disorder. Among its related pathways are Neural Crest Differentiation. An important paralog of this gene is IGDCC4.

UniProtKB/Swiss-Prot for PRTG Gene

  • May play a role in anteroposterior axis elongation.

Additional gene information for PRTG Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRTG Gene

Genomics for PRTG Gene

Regulatory Elements for PRTG Gene

Enhancers for PRTG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H056037 1.7 FANTOM5 Ensembl ENCODE 21.2 -297.3 -297333 6.5 PKNOX1 FOXA2 MLX FEZF1 DMAP1 ZNF2 YY1 ZNF766 FOS DEK ZNF280D RFX7 RSL24D1 TEX9 PYGO1 PRTG PIGBOS1 MNS1 TCF12 RN7SL568P
GH15H055912 1.3 Ensembl ENCODE dbSUPER 19.1 -172.1 -172096 6.3 TBP FOXA2 SIN3A FEZF1 BRCA1 RAD21 RFX5 ZSCAN5C ZNF143 RCOR1 PRTG NEDD4 GC15P055749
GH15H055627 1.1 Ensembl ENCODE 20.6 +115.5 115548 1.6 GTF2F1 PKNOX1 MXI1 JUN MAX BRCA1 RFX5 FOSL1 HIC1 POLR2A PRTG PYGO1 ENSG00000259180
GH15H055768 0.5 ENCODE 35.3 -25.2 -25232 1 SMARCE1 ESRRA FOS DPF2 PRTG PYGO1 GC15P055749 NEDD4
GH15H055694 1.2 FANTOM5 ENCODE 13.6 +48.8 48801 1 PKNOX1 ARNT INSM2 FEZF1 BATF ZNF366 ZSCAN5C ETV6 OVOL3 JUNB PRTG ENSG00000259180 GC15M056978
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRTG on UCSC Golden Path with GeneCards custom track

Promoters for PRTG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076849 949 2201 MLX ZFP64 ARID4B SIN3A DMAP1 BRCA1 GLIS2 ZNF143 KLF7 SP3

Genomic Locations for PRTG Gene

Genomic Locations for PRTG Gene
132,110 bases
Minus strand

Genomic View for PRTG Gene

Genes around PRTG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRTG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRTG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRTG Gene

Proteins for PRTG Gene

  • Protein details for PRTG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8N7D8

    Protein attributes for PRTG Gene

    1150 amino acids
    Molecular mass:
    127076 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05355.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PRTG Gene

Post-translational modifications for PRTG Gene

  • Glycosylation at Asn90, isoforms=488, and isoforms=630
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRTG Gene

Domains & Families for PRTG Gene

Gene Families for PRTG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRTG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. DCC family.
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with PRTG: view

Function for PRTG Gene

Molecular function for PRTG Gene

UniProtKB/Swiss-Prot Function:
May play a role in anteroposterior axis elongation.

Phenotypes From GWAS Catalog for PRTG Gene

genes like me logo Genes that share phenotypes with PRTG: view

miRNA for PRTG Gene

miRTarBase miRNAs that target PRTG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRTG Gene

Localization for PRTG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRTG Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRTG gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRTG: view

Pathways & Interactions for PRTG Gene

SuperPathway Contained pathways
1 Neural Crest Differentiation
genes like me logo Genes that share pathways with PRTG: view

Pathways by source for PRTG Gene

1 BioSystems pathway for PRTG Gene

Interacting Proteins for PRTG Gene

Gene Ontology (GO) - Biological Process for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with PRTG: view

No data available for SIGNOR curated interactions for PRTG Gene

Drugs & Compounds for PRTG Gene

No Compound Related Data Available

Transcripts for PRTG Gene

mRNA/cDNA for PRTG Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRTG Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRTG Gene

No ASD Table

Relevant External Links for PRTG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRTG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRTG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRTG Gene

This gene is overexpressed in Thyroid (x11.5).

Protein differential expression in normal tissues from HIPED for PRTG Gene

This gene is overexpressed in Pancreatic juice (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRTG Gene

Protein tissue co-expression partners for PRTG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRTG Gene:


SOURCE GeneReport for Unigene cluster for PRTG Gene:

genes like me logo Genes that share expression patterns with PRTG: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRTG Gene

Orthologs for PRTG Gene

This gene was present in the common ancestor of animals.

Orthologs for PRTG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRTG 33 34
  • 99.59 (n)
(Canis familiaris)
Mammalia PRTG 33 34
  • 93.04 (n)
(Bos Taurus)
Mammalia PRTG 33 34
  • 91.17 (n)
(Monodelphis domestica)
Mammalia PRTG 34
  • 91 (a)
(Mus musculus)
Mammalia Prtg 33 16 34
  • 84.82 (n)
(Rattus norvegicus)
Mammalia Prtg 33
  • 84.46 (n)
(Ornithorhynchus anatinus)
Mammalia PRTG 34
  • 84 (a)
(Gallus gallus)
Aves PRTG 33 34
  • 79.62 (n)
(Anolis carolinensis)
Reptilia PRTG 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prtg 33
  • 71.68 (n)
(Danio rerio)
Actinopterygii prtga 33
  • 63.07 (n)
prtgb 34
  • 57 (a)
PRTG (2 of 2) 34
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cont 34
  • 14 (a)
Species where no ortholog for PRTG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRTG Gene

Gene Tree for PRTG (if available)
Gene Tree for PRTG (if available)

Paralogs for PRTG Gene

Paralogs for PRTG Gene

(11) SIMAP similar genes for PRTG Gene using alignment to 4 proteins: Pseudogenes for PRTG Gene

genes like me logo Genes that share paralogs with PRTG: view

Variants for PRTG Gene

Sequence variations from dbSNP and Humsavar for PRTG Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000016155 -- 55,671,456(+) TTGAT(A/G)AGTTT intron-variant
rs1000016587 -- 55,691,273(+) CCTGG(G/T)AAACA intron-variant
rs1000030533 -- 55,624,107(+) TATAA(A/G)TGAGA intron-variant
rs1000061945 -- 55,659,608(+) GACTA(C/T)AAAGC intron-variant
rs1000085823 -- 55,708,232(+) TGGAA(A/C)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRTG Gene

Variant ID Type Subtype PubMed ID
nsv833017 CNV loss 17160897
nsv569541 CNV loss 21841781
nsv569540 CNV gain 21841781
nsv569539 CNV loss 21841781
nsv457158 CNV loss 19166990
nsv1052495 CNV gain 25217958
nsv1043789 CNV gain 25217958
esv3636569 CNV gain 21293372
esv3636567 CNV loss 21293372
esv3581712 CNV loss 25503493
esv3581711 CNV loss 25503493
esv3569609 CNV gain 25503493
esv2761899 CNV gain+loss 21179565

Variation tolerance for PRTG Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.43; 81.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRTG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRTG Gene

Disorders for PRTG Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRTG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards
Search PRTG in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRTG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRTG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRTG Gene

Publications for PRTG Gene

  1. Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region. (PMID: 19076634) Wigg KG … Barr CL (Genes, brain, and behavior 2008) 3 22 45 60
  2. Identification of protogenin, a novel immunoglobulin superfamily gene expressed during early chick embryogenesis. (PMID: 15922677) Toyoda R … Watanabe Y (Gene expression patterns : GEP 2005) 3 22 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low SK … Nakamura Y (Cancer science 2013) 3 60

Products for PRTG Gene

Sources for PRTG Gene

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