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Aliases for PRTG Gene

Aliases for PRTG Gene

  • Protogenin 2 3 5
  • Protogenin Homolog (Gallus Gallus) 2 3
  • Immunoglobulin Superfamily, DCC Subclass, Member 5 3
  • Immunoglobulin Superfamily 2
  • Protein Shen-Dan 4
  • DCC Subclass 2
  • Member 5 2
  • Shen-Dan 3
  • IGDCC5 3

External Ids for PRTG Gene

Previous GeneCards Identifiers for PRTG Gene

  • GC15M053700
  • GC15M055903
  • GC15M032727

Summaries for PRTG Gene

Entrez Gene Summary for PRTG Gene

  • This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]

GeneCards Summary for PRTG Gene

PRTG (Protogenin) is a Protein Coding gene. Diseases associated with PRTG include attention deficit-hyperactivity disorder. Among its related pathways are Neural Crest Differentiation. An important paralog of this gene is IGDCC3.

UniProtKB/Swiss-Prot for PRTG Gene

  • May play a role in anteroposterior axis elongation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRTG Gene

Genomics for PRTG Gene

Regulatory Elements for PRTG Gene

Promoters for PRTG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRTG on UCSC Golden Path with GeneCards custom track

Genomic Location for PRTG Gene

55,611,540 bp from pter
55,743,649 bp from pter
132,110 bases
Minus strand

Genomic View for PRTG Gene

Genes around PRTG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRTG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRTG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRTG Gene

Proteins for PRTG Gene

  • Protein details for PRTG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8N7D8

    Protein attributes for PRTG Gene

    1150 amino acids
    Molecular mass:
    127076 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05355.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PRTG Gene

Proteomics data for PRTG Gene at MOPED

Post-translational modifications for PRTG Gene

  • Glycosylation at Asn 90, Asn 488, and Asn 630
  • Modification sites at PhosphoSitePlus

Other Protein References for PRTG Gene

Antibody Products

No data available for DME Specific Peptides for PRTG Gene

Domains & Families for PRTG Gene

Protein Domains for PRTG Gene

Suggested Antigen Peptide Sequences for PRTG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 fibronectin type-III domains.
  • Belongs to the immunoglobulin superfamily. DCC family.
  • Contains 5 fibronectin type-III domains.
  • Contains 4 Ig-like (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with PRTG: view

Function for PRTG Gene

Molecular function for PRTG Gene

UniProtKB/Swiss-Prot Function:
May play a role in anteroposterior axis elongation.

Phenotypes for PRTG Gene

genes like me logo Genes that share phenotypes with PRTG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRTG

miRNA for PRTG Gene

miRTarBase miRNAs that target PRTG

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRTG Gene

Localization for PRTG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRTG Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PRTG Gene COMPARTMENTS Subcellular localization image for PRTG gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRTG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRTG: view

Pathways & Interactions for PRTG Gene

SuperPathways for PRTG Gene

genes like me logo Genes that share pathways with PRTG: view

Pathways by source for PRTG Gene

1 BioSystems pathway for PRTG Gene

Interacting Proteins for PRTG Gene

Gene Ontology (GO) - Biological Process for PRTG Gene


No data available for SIGNOR curated interactions for PRTG Gene

Drugs & Compounds for PRTG Gene

No Compound Related Data Available

Transcripts for PRTG Gene

mRNA/cDNA for PRTG Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRTG Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRTG Gene

No ASD Table

Relevant External Links for PRTG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRTG Gene

mRNA expression in normal human tissues for PRTG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRTG Gene

This gene is overexpressed in Thyroid (x11.5).

Protein differential expression in normal tissues from HIPED for PRTG Gene

This gene is overexpressed in Pancreatic juice (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRTG Gene

SOURCE GeneReport for Unigene cluster for PRTG Gene Hs.130957

genes like me logo Genes that share expression patterns with PRTG: view

Protein tissue co-expression partners for PRTG Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PRTG Gene

Orthologs for PRTG Gene

This gene was present in the common ancestor of animals.

Orthologs for PRTG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRTG 35
  • 91.17 (n)
  • 94.07 (a)
  • 90 (a)
(Canis familiaris)
Mammalia PRTG 35
  • 93.04 (n)
  • 96.24 (a)
  • 91 (a)
(Mus musculus)
Mammalia Prtg 35
  • 84.82 (n)
  • 91.1 (a)
Prtg 16
Prtg 36
  • 87 (a)
(Pan troglodytes)
Mammalia PRTG 35
  • 99.59 (n)
  • 99.74 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Prtg 35
  • 84.46 (n)
  • 91.01 (a)
(Monodelphis domestica)
Mammalia PRTG 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia PRTG 36
  • 84 (a)
(Gallus gallus)
Aves PRTG 35
  • 79.62 (n)
  • 85.94 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia PRTG 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prtg 35
  • 71.68 (n)
  • 71.95 (a)
(Danio rerio)
Actinopterygii prtga 35
  • 63.07 (n)
  • 64.29 (a)
PRTG (2 of 2) 36
  • 53 (a)
prtgb 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cont 36
  • 14 (a)
Species with no ortholog for PRTG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRTG Gene

Gene Tree for PRTG (if available)
Gene Tree for PRTG (if available)

Paralogs for PRTG Gene

Paralogs for PRTG Gene

(11) SIMAP similar genes for PRTG Gene using alignment to 4 proteins: Pseudogenes for PRTG Gene

genes like me logo Genes that share paralogs with PRTG: view

Variants for PRTG Gene

Sequence variations from dbSNP and Humsavar for PRTG Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1438914 - 55,620,677(-) AGAAG(A/T)TACAA nc-transcript-variant, reference, missense
rs16976466 - 55,680,599(+) AATTG(C/T)TGGTG nc-transcript-variant, reference, missense
rs10518816 - 55,637,317(+) TTTTA(C/G)TCCAA nc-transcript-variant, reference, missense
rs541656 -- 55,617,940(-) AGCAT(A/G)GGCAG nc-transcript-variant, utr-variant-3-prime
rs550226 -- 55,682,548(+) ATTTT(A/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRTG Gene

Variant ID Type Subtype PubMed ID
nsv457158 CNV Loss 19166990
nsv833017 CNV Loss 17160897

Variation tolerance for PRTG Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.43; 81.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRTG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRTG Gene

Disorders for PRTG Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRTG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards
Search PRTG in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRTG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRTG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRTG Gene

Publications for PRTG Gene

  1. Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region. (PMID: 19076634) Wigg K.G. … Barr C.L. (Genes Brain Behav. 2008) 3 23 48 67
  2. Identification of protogenin, a novel immunoglobulin superfamily gene expressed during early chick embryogenesis. (PMID: 15922677) Toyoda R. … Watanabe Y. (Gene Expr. Patterns 2005) 3 23
  3. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3
  4. MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin. (PMID: 24007463) Song J. … Jin E.J. (Cell Commun. Signal 2013) 3
  5. Nuclear translocation of intracellular domain of Protogenin by proteolytic cleavage. (PMID: 22150322) Watanabe Y. … Nakamura H. (Dev. Growth Differ. 2012) 3

Products for PRTG Gene

Sources for PRTG Gene

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