Aliases for PRSS8 Gene
External Ids for PRSS8 Gene
Previous GeneCards Identifiers for PRSS8 Gene
This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]
GeneCards Summary for PRSS8 Gene
PRSS8 (Protease, Serine 8) is a Protein Coding gene. Diseases associated with PRSS8 include Ichthyosis, Follicular and Chromophobe Renal Cell Carcinoma. Among its related pathways are Keratinization and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is PRSS33.
UniProtKB/Swiss-Prot for PRSS8 Gene
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).