Aliases for PRSS8 Gene
External Ids for PRSS8 Gene
Previous GeneCards Identifiers for PRSS8 Gene
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRSS8 Gene
PRSS8 (Protease, Serine, 8) is a Protein Coding gene. Diseases associated with PRSS8 include ichthyosis, follicular and chromophobe renal cell carcinoma. Among its related pathways are L1CAM interactions and Hemostasis. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TPSAB1.
UniProtKB/Swiss-Prot for PRSS8 Gene
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).