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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRSS8 Gene

protein-coding GIFtS: 62
GCID: GC16M031142

protease, serine, 8

Explore 28 diseases affiliated with
PRSS8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protease, Serine, 8¹ ²		Prostasin¹
Channel-Activating Protease 1² ³		EC 3.4.21.-³
Serine Protease 8² ³		EC 3.4.21⁸
CAP1² ³		EC 3.4.21.120⁸
PROSTASIN²

External Ids:	HGNC: 9491¹	Entrez Gene: 5652²	Ensembl: ENSG00000052344⁷	OMIM: 600823⁵	UniProtKB: Q16651³

Export aliases for PRSS8 gene to outside databases

Previous GC identifers: GC16M030224 GC16M031639 GC16M031139 GC16M031178 GC16M031050 GC16M028703

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRSS8:

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly

expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is

cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide

linkages involving the carboxyl group of lysine or arginine. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PRSS8_HUMAN, Q16651

Function: Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates

epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G)

Gene Wiki entry for PRSS8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRSS8 gene promoter:
TBP NF-1 Pax-5 MAZR AP-4 LCR-F1 Tal-1beta AREB6 HEN1 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRSS8 promoter sequence

Search SABiosciences Chromatin IP Primers for PRSS8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

PRSS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS8 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M031142: view genomic region (about GC identifiers)

Start:	31,142,754 bp from pter	End:	31,147,151 bp from pter
Size:	4,398 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRSS8_HUMAN, Q16651 (See protein sequence)

Recommended Name: Prostasin precursor

Size: 343 amino acids; 36431 Da

Subunit: Heterodimer of two chains, light and heavy, held by a disulfide bond

Subcellular location: Prostasin: Cell membrane; Single-pass membrane protein

Subcellular location: Prostasin light chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted

after cleavage of its C-terminus

Subcellular location: Prostasin heavy chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted

after cleavage of its C-terminus

6/9 PDB 3D structures from and Proteopedia for PRSS8 (see all 9):

3DFJ (3D)

3DFL (3D)

3E0N (3D)

3E0P (3D)

3E16 (3D)

3E1X (3D)

Secondary accessions: Q9UCA3

Explore the universe of human proteins at neXtProt for PRSS8: NX_Q16651

4/7 DME Specific Peptides for PRSS8 (Q16651) (see all 7)

TGIVSWG

GDSGGPL

LQQLEVP

IRPICLP

PRSS8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002764.1

ENSEMBL proteins:

ENSP00000319730 ENSP00000457750 ENSP00000457673 ENSP00000458056

Human Recombinant Protein Products:

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	Novus Biologicals PRSS8 Proteins Novus Biologicals PRSS8 Lysate
	Sino Biological Recombinant Protein for PRSS8
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PRSS8

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	10077646
GO:0005615	extracellular space	IEA	--
GO:0005886	plasma membrane	IDA	19911255
GO:0016021	integral to membrane	IEA	--

PRSS8 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PRSS8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRSS8 for domains About GeneDecksing

4 InterPro domains/families:

IPR001314 Peptidase_S1A

IPR001254 Peptidase_S1

IPR018114 Peptidase_S1_AS

IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry Q16651

ProtoNet protein and cluster: Q16651

2 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: PRSS8_HUMAN, Q16651

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 1 peptidase S1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PRSS8_HUMAN, Q16651

Function: Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates

epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G)

Genatlas biochemistry entry for PRSS8:

protease serine 8,prostasin from the seminal fluid,with strong homology to acrosin,plasma kallikrein and

hepsin,predominantly expressed in prostate

Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.120² EC 3.4.21.-¹

miRNA Products:		miRTarBase miRNAs that target PRSS8: hsa-mir-1 (MIRT002798)

		OriGene 3'-UTR Clone: PRSS8 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRSS8
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate PRSS8:
		hsa-miR-4283 hsa-miR-4264 hsa-miR-31 hsa-miR-1203 hsa-miR-455-3p hsa-miR-24 hsa-miR-1910 hsa-miR-1289

		SwitchGear 3'UTR luciferase reporter plasmid: PRSS8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRSS8 (see all 7) OriGene shRNA RFP: PRSS8 OriGene siRNA: PRSS8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS8

Gene Editing
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DNA2.0 Custom Protein Engineering Service for PRSS8

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS8

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	19911255
GO:0008236	serine-type peptidase activity	TAS	8034638
GO:0017080	sodium channel regulator activity	--	--

PRSS8 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PRSS8:

Decreased influenza A virus in

Decreased nuclei size in G2M

Animal Models:
Mouse knock-out Prss8^tm1.1Hum for PRSS8
11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Prss8):

embryogenesis	growth/size	hematopoietic system	homeostasis/metabolism	immune system
integument	limbs/digits/tail	mortality/aging	nervous system	no phenotypic analysis
normal

PRSS8 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for PRSS8

CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PRSS8

1 Interacting protein for PRSS8 (Q16651^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF7IP	Q6VMQ6²^,³	MINT-61922 I2D: score=3

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0010765	positive regulation of sodium ion transport	IEA	--
GO:0042493	response to drug	--	--
GO:0043434	response to peptide hormone stimulus	--	--
GO:0051385	response to mineralocorticoid stimulus	--	--

PRSS8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PRSS8 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PRSS8

1 DrugBank Compound for PRSS8 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1-[4-(hydroxymethyl)phenyl]guanidine	--	--	target	--	10592235

5 Novoseek chemical compound relationships for PRSS8 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	79.7	76	12506133 (4), 11274175 (4), 11967240 (4), 8034638 (3) (see all 38)
aprotinin	71.3	5	11373334 (2), 12506133 (1), 15246975 (1)
sodium	65.6	56	11373334 (4), 16172430 (4), 12506133 (3), 19262497 (3) (see all 20)
nitric oxide	0	1	16638913 (1)
potassium	0	2	11373334 (1)

Search CenterWatch for drugs/clinical trials and news about PRSS8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRSS8 gene:

NM_002773.3

Unigene Cluster for PRSS8:

Protease, serine, 8

Hs.75799 [show with all ESTs]

Unigene Representative Sequence: NM_002773

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000317508(uc002ebc.4 uc010vfe.2) ENST00000568261 ENST00000567531

ENST00000567797 ENST00000564025 ENST00000567833

miRNA Products:		OriGene 3'-UTR Clone: PRSS8 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRSS8
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate PRSS8:
		hsa-miR-4283 hsa-miR-4264 hsa-miR-31 hsa-miR-1203 hsa-miR-455-3p hsa-miR-24 hsa-miR-1910 hsa-miR-1289

		SwitchGear 3'UTR luciferase reporter plasmid: PRSS8 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS8

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		GenScript: all cDNA clones in your preferred vector: PRSS8 (NM_002773)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS8

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PRSS8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS8

Additional cDNA sequence:

AK296656.1 AK301619.1 AK309955.1 BC001462.2 L41351.1

13 DOTS entries:

DT.85100542 DT.95104069 DT.97806684 DT.100823093 DT.95104125 DT.120688803 DT.120688858 DT.95104117

DT.100823091 DT.120688813 DT.95104070 DT.120688814 DT.102823948

24/266 AceView cDNA sequences (see all 266):

AW778959 AW050883 BG959233 BE350060 BM987453 BP356278 BE266238 BM773139

L41351 CK821693 BF732394 CR624569 AI207298 BM976513 BP341498 AW591183

BM850714 BP342678 CB851551 AI186484 AI676068 AI457933 BP368689 BP334748

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS8 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6
SP1:
SP2:
SP3:					-

ECgene alternative splicing isoforms for PRSS8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRSS8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCAGCCCA

About this image

PRSS8 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRSS8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRSS8

SOURCE GeneReport for Unigene cluster: Hs.75799

UniProtKB/Swiss-Prot: PRSS8_HUMAN, Q16651

Tissue specificity: Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal

proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and

excreted into the seminal fluid

SABiosciences Custom PCR Arrays for PRSS8

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PRSS8 gene from 3/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	PRSS8⁶	--	48(a)	1 ↔ 1	GL343220.1(2308452-2314067)
zebrafish (Danio rerio)	Actinopterygii	LOC100001520¹	serine protease 27-like	49.63(n) 44.03(a)		100001520 XM_001341462.1 XP_001341498.1
fruit fly (Drosophila melanogaster)	Insecta	CG8170³	serine-type endopeptidase	36(a) (best of 9)		45A1 --

ENSEMBL Gene Tree for PRSS8 (if available)
TreeFam Gene Tree for PRSS8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRSS8 gene

PRSS46² PRSS55² PRSS48² PRSS22² PRSS27² PRSS21² PRSS45² TPSG1²

TPSD1² PRSS38² TPSAB1² PRSS53² PRSS50² PRSS42² PRSS36² PRSS33²

KLKB1² F11² OVCH1²

18/98 SIMAP similar genes for PRSS8 using alignment to 4 protein entries: PRSS8_HUMAN (see all proteins) (see all similar genes):

PRSS45 KLKB1 TMPRSS11B PRSS1 PRSS33 TMPRSS3

CELA3A PRSS48 TMPRSS13 tryptaseC HGFAC PRSS42

TPSB2 CTRB1 CELA2B ELA2A F11 GZMK

PRSS8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78242929^1,2	C,	--	31142350(+)	`GAGCCC/TGGGGC`	3	--	ds500¹ int¹ ut3¹		2		CSA WA	120
rs2855479^1,2	C,	--	31142381(-)	`AGGGGC/TAGGGA`	2	--	int¹ ds500¹		11		NA WA CSA EA	373
rs189182463^1,2		--	31142383(+)	`CCTACC/TCCTCC`	3	--	ds500¹ int¹ ut3¹		0	--	--	--	--
rs114151001^1,2	C,F,	--	31142412(+)	`TTGTTC/TTCACC`	3	--	ut3¹ int¹ ds500¹		1		WA	118
rs1047491^1,2	C	--	31142675(+)	`CAGTTC/TTGGTG`	3	--	ut3¹ ds500¹		0	--	--	--	--
rs192276914^1,2		--	31142717(+)	`AGAGCA/GGATGT`	3	--	ds500¹ int¹		0	--	--	--	--
rs78264150^1,2	C,	--	31142722(+)	`GGATGG/TTCTTC`	3	--	int¹ ds500¹		0	--	--	--	--
rs117219760^1,2	F,	--	31142767(+)	`AAACAT/GTTTAA`	3	--	ut3¹ int¹		1		NA	120
rs117174323^1,2	F,	--	31142842(+)	`TCCTCC/TGGAGT`	3	--	ut3¹ int¹		1		EA	120
rs140647741^1,2		--	31142863(+)	`GGGCTC/TGGGGG`	3	--	ut3¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PRSS8 (31142754 - 31147151 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRSS8: --
Human Gene Mutation Database (HGMD): PRSS8

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRSS8

DNA2.0 Custom Variant and Variant Library Synthesis for PRSS8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PRSS8 for disorders           About GeneDecksing

OMIM gene information: 600823    OMIM disorders: --

20/28 diseases for PRSS8 (see all 28):    About MalaCards

prostatitis testicular germ cell tumor chromophobe renal cell carcinoma germ cell tumor

pseudohypoaldosteronism ichthyosis, follicular hypotrichosis ichthyosis

ichthyosis with hypotrichosis hypohidrosis renal cell carcinoma cystic fibrosis

basal cell carcinoma epithelial ovarian cancer essential hypertension ovarian cancer

aldosteronism squamous cell carcinoma fibrosis prostate carcinoma

10/12 Novoseek disease relationships for PRSS8 gene (see all 12) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pseudohypoaldosteronism	68.3	1	15547682 (1)
aldosteronism primary	37.9	4	11828000 (3), 16172430 (1)
benign prostatic hyperplasia	33.5	1	19670249 (1)
prostate carcinoma	28.1	3	17532063 (2), 18054338 (1)
invasive cancer	27.8	2	19670249 (1), 19849847 (1)
cystic fibrosis	21.1	9	15246975 (3), 18310226 (1), 12460120 (1)
ovarian cancer	20.7	7	11584061 (3), 19606239 (3)
prostate cancer	19.5	8	11433419 (3), 12518323 (3), 16541421 (1), 19670249 (1)
cancer	3.11	8	12518323 (2), 19555470 (2), 18054338 (1), 16103126 (1)
carcinoma	2.69	2	11173941 (1), 19555470 (1)

Human Genome Epidemiology (HuGE) Navigator: PRSS8 (2 documents)

Export disorders for PRSS8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PRSS8 gene, integrated from 9 sources (see all 90):
(articles sorted by number of sources associating them with PRSS8)

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Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA. (PubMed id 7768952)^{1, 2, 3, 9} Yu J.X.... Chao J. (1995)
Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. (PubMed id 15246975)^{1, 2, 9} Tong Z....Caughey G.H. (2004)
Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland. (PubMed id 8034638)^{1, 2, 9} Yu J.X.... Chao J. (1994)
Biochemical characterization of prostasin, a channel activating protease. (PubMed id 15474520)^{1, 2, 9} Shipway A....Harris J.L. (2004)
Structure and chromosomal localization of the human prostasin (PRSS8) gene. (PubMed id 8838796)^{1, 3, 9} Yu J.X....Chao J. (1996)
Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. (PubMed id 19388054)^{1, 2, 9} Spraggon G....Lesley S.A. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Urinary prostasin in humans: relationships among prostasin, aldosterone and epithelial sodium channel activity. (PubMed id 19262497)^{1, 9} Koda A....Kitamura K. (2009)
Loss of prostasin (PRSS8) in human bladder transition al cell carcinoma cell lines is associated with epithelial-mesenchymal transiti on (EMT). (PubMed id 19849847)^{1, 9} Chen L.M....Chai K.X. (2009)
Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin. (PubMed id 16103126)^{1, 9} Fan B....Kirchhofer D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5652	HGNC: 9491	AceView: PRSS8	Ensembl:ENSG00000052344	euGenes: HUgn5652
ECgene: PRSS8	H-InvDB: PRSS8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRSS8	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PRSS8	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PRSS8 gene
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Patent Information for PRSS8 gene:
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