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Aliases for PRSS8 Gene

Aliases for PRSS8 Gene

  • Protease, Serine, 8 2 3
  • Channel-Activating Protease 1 3 4
  • Serine Protease 8 3 4
  • CAP1 3 4
  • EC 3.4.21.120 63
  • EC 3.4.21.- 4
  • Prostasin 2
  • PROSTASIN 3
  • EC 3.4.21 63

External Ids for PRSS8 Gene

Previous GeneCards Identifiers for PRSS8 Gene

  • GC16M030224
  • GC16M031639
  • GC16M031139
  • GC16M031178
  • GC16M031050
  • GC16M028703

Summaries for PRSS8 Gene

Entrez Gene Summary for PRSS8 Gene

  • This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS8 Gene

PRSS8 (Protease, Serine, 8) is a Protein Coding gene. Diseases associated with PRSS8 include ichthyosis, follicular and conn's syndrome. Among its related pathways are Developmental Biology and Hemostasis. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TPSAB1.

UniProtKB/Swiss-Prot for PRSS8 Gene

  • Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).

Gene Wiki entry for PRSS8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS8 Gene

Genomics for PRSS8 Gene

Regulatory Elements for PRSS8 Gene

Genomic Location for PRSS8 Gene

Chromosome:
16
Start:
31,131,433 bp from pter
End:
31,135,830 bp from pter
Size:
4,398 bases
Orientation:
Minus strand

Genomic View for PRSS8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS8 Gene

Proteins for PRSS8 Gene

  • Protein details for PRSS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16651-PRSS8_HUMAN
    Recommended name:
    Prostasin
    Protein Accession:
    Q16651
    Secondary Accessions:
    • B4DWP2
    • Q9UCA3

    Protein attributes for PRSS8 Gene

    Size:
    343 amino acids
    Molecular mass:
    36431 Da
    Quaternary structure:
    • Heterodimer of two chains, light and heavy, held by a disulfide bond.

    Three dimensional structures from OCA and Proteopedia for PRSS8 Gene

    Alternative splice isoforms for PRSS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS8 Gene

Proteomics data for PRSS8 Gene at MOPED

Selected DME Specific Peptides for PRSS8 Gene

Post-translational modifications for PRSS8 Gene

Other Protein References for PRSS8 Gene

Antibody Products

  • R&D Systems Antibodies for PRSS8 (Prostasin/Prss8)

Domains & Families for PRSS8 Gene

Gene Families for PRSS8 Gene

Suggested Antigen Peptide Sequences for PRSS8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16651

UniProtKB/Swiss-Prot:

PRSS8_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS8: view

Function for PRSS8 Gene

Molecular function for PRSS8 Gene

GENATLAS Biochemistry:
protease serine 8,prostasin from the seminal fluid,with strong homology to acrosin,plasma kallikrein and hepsin,predominantly expressed in prostate
UniProtKB/Swiss-Prot Function:
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).

Enzyme Numbers (IUBMB) for PRSS8 Gene

Gene Ontology (GO) - Molecular Function for PRSS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 19911255
GO:0008236 serine-type peptidase activity TAS 8034638
genes like me logo Genes that share ontologies with PRSS8: view
genes like me logo Genes that share phenotypes with PRSS8: view

Animal Models for PRSS8 Gene

MGI Knock Outs for PRSS8:

Animal Model Products

miRNA for PRSS8 Gene

miRTarBase miRNAs that target PRSS8

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS8

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PRSS8 Gene

Localization for PRSS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS8 Gene

Prostasin: Cell membrane; Single-pass membrane protein.
Prostasin light chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Prostasin heavy chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS8 Gene COMPARTMENTS Subcellular localization image for PRSS8 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PRSS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10077646
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane IDA 19911255
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PRSS8: view

Pathways & Interactions for PRSS8 Gene

genes like me logo Genes that share pathways with PRSS8: view

Pathways by source for PRSS8 Gene

Interacting Proteins for PRSS8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000319730%0d%0a9606.ENSP00000405812%0d%0a
Selected Interacting proteins: Q16651-PRSS8_HUMAN ENSP00000319730 for PRSS8 Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for PRSS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0010765 positive regulation of sodium ion transport IEA --
genes like me logo Genes that share ontologies with PRSS8: view

No data available for SIGNOR curated interactions for PRSS8 Gene

Drugs & Compounds for PRSS8 Gene

(6) Drugs for PRSS8 Gene - From: NovoSeek, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin Approved, Withdrawn Pharma Inhibitor of bovine pancreatic trypsin 24
Nitric Oxide Approved Pharma 540
1-[4-(hydroxymethyl)phenyl]guanidine Experimental Pharma Target 0
Potassium Experimental Pharma 0
B3C Pharma 0

(1) Additional Compounds for PRSS8 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with PRSS8: view

Transcripts for PRSS8 Gene

Unigene Clusters for PRSS8 Gene

Protease, serine, 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2:
SP3: -

Relevant External Links for PRSS8 Gene

GeneLoc Exon Structure for
PRSS8
ECgene alternative splicing isoforms for
PRSS8

Expression for PRSS8 Gene

mRNA expression in normal human tissues for PRSS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS8 Gene

This gene is overexpressed in Colon - Transverse (x7.4), Minor Salivary Gland (x5.1), Stomach (x5.1), Esophagus - Mucosa (x4.9), Small Intestine - Terminal Ileum (x4.3), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for PRSS8 Gene

This gene is overexpressed in Urine (18.3), Thyroid (16.7), Saliva (14.0), and Pancreatic juice (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRSS8 Gene



SOURCE GeneReport for Unigene cluster for PRSS8 Gene Hs.75799

mRNA Expression by UniProt/SwissProt for PRSS8 Gene

Q16651-PRSS8_HUMAN
Tissue specificity: Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid
genes like me logo Genes that share expression patterns with PRSS8: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for PRSS8 Gene

Orthologs for PRSS8 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRSS8 35
  • 80.06 (n)
  • 72.59 (a)
PRSS8 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS8 35
  • 85.32 (n)
  • 83.02 (a)
PRSS8 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss8 35
  • 80.14 (n)
  • 77.16 (a)
Prss8 16
Prss8 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRSS8 35
  • 99.42 (n)
  • 99.42 (a)
PRSS8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss8 35
  • 78.75 (n)
  • 76.32 (a)
oppossum
(Monodelphis domestica)
Mammalia PRSS8 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS8 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRSS8 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prss8 35
  • 56.48 (n)
  • 48.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1299 37
  • 33 (a)
CG4998 37
  • 34 (a)
CG7432 37
  • 36 (a)
CG8170 37
  • 36 (a)
CG8172 37
  • 32 (a)
CG8213 37
  • 34 (a)
mas 37
  • 33 (a)
ndl 37
  • 33 (a)
Sb 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea C07G1.1 37
  • 36 (a)
ZK546.15 37
  • 33 (a)
Species with no ortholog for PRSS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PRSS8 Gene

ENSEMBL:
Gene Tree for PRSS8 (if available)
TreeFam:
Gene Tree for PRSS8 (if available)

Paralogs for PRSS8 Gene

genes like me logo Genes that share paralogs with PRSS8: view

Variants for PRSS8 Gene

Sequence variations from dbSNP and Humsavar for PRSS8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2550048 -- 31,136,084(-) atgca(C/T)gcaca upstream-variant-2KB
rs2550049 -- 31,135,117(-) GGGGG(A/T)GGTGA intron-variant
rs2550050 -- 31,134,942(-) ggatt(C/G)agatc intron-variant
rs2550051 -- 31,134,559(-) TTCCC(A/G)TCCTG intron-variant
rs2550052 -- 31,134,424(-) ccccc(C/G)acttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS8 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
dgv2672n71 CNV Loss 21882294

Variation tolerance for PRSS8 Gene

Residual Variation Intolerance Score: 23.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS8 Gene

HapMap Linkage Disequilibrium report
PRSS8
Human Gene Mutation Database (HGMD)
PRSS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS8 Gene

Disorders for PRSS8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRSS8 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
ichthyosis, follicular
  • follicular ichthyosis
conn's syndrome
  • primary aldosteronism
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association
Search PRSS8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRSS8

Genetic Association Database (GAD)
PRSS8
Human Genome Epidemiology (HuGE) Navigator
PRSS8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS8
genes like me logo Genes that share disorders with PRSS8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS8 Gene

Publications for PRSS8 Gene

  1. Structure and chromosomal localization of the human prostasin (PRSS8) gene. (PMID: 8838796) Yu J.X. … Chao J. (Genomics 1996) 2 23 67
  2. Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA. (PMID: 7768952) Yu J.X. … Chao J. (J. Biol. Chem. 1995) 2 23 67
  3. Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases. (PMID: 20401730) Gaillard E.A. … Tarran R. (Pflugers Arch. 2010) 23 67
  4. Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor. (PMID: 19911255) Chen M. … Chai K.X. (Mol. Cell. Biochem. 2010) 23 67
  5. Prostasin regulates human placental trophoblast cell proliferation via the epidermal growth factor receptor signaling pathway. (PMID: 20089521) Fu Y.Y. … Chen L.M. (Hum. Reprod. 2010) 23 67

Products for PRSS8 Gene

Sources for PRSS8 Gene

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