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PRSS58 Gene

protein-coding   GIFtS: 39
GCID: GC07M141952

Protease, Serine, 58

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 581 2     UNQ25402
Trypsin X31 2     Serine Protease 582
TRY12 3     trypsin-X32
TRYX32 3     EC 3.4.21.43
PRSS12     Trypsin-X33

External Ids:    HGNC: 391251   Entrez Gene: 1365412   Ensembl: ENSG000002582237   UniProtKB: Q8IYP23   

Export aliases for PRSS58 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRSS58 Gene:
This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen
genes are localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as a
trypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRSS58 Gene:
PRSS58 (protease, serine, 58) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK10.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  NT_187562.1  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PRSS58
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS58 promoter sequence
   Search Chromatin IP Primers for PRSS58

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS58


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

PRSS58 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS58 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M141952:  view genomic region     (about GC identifiers)

Start:
141,951,958 bp from pter      End:
141,957,878 bp from pter
Size:
5,921 bases      Orientation:
minus strand

2 alternative locations:
Chr7-,NW_003571040 394,109-400,029      Chr7-,CRA_TCAG 141,290,166-141,296,085     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRS58_HUMAN, Q8IYP2 (See protein sequence)
Recommended Name: Serine protease 58 precursor  
Size: 241 amino acids; 27085 Da
Secondary accessions: B3KVJ6 D3DXD2

Explore the universe of human proteins at neXtProt for PRSS58: NX_Q8IYP2

Explore proteomics data for PRSS58 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn156, Asn173

  • See PRSS58 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001317.1  
    ENSEMBL proteins: 
     ENSP00000447588   ENSP00000446916  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q8IYP2

    ProtoNet protein and cluster: Q8IYP2

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRS58_HUMAN, Q8IYP2
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PRSS58           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRS58_HUMAN, Q8IYP2
    Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa

         Enzyme Number (IUBMB): EC 3.4.21.41

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    Find genes that share ontologies with PRSS58           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRSS58:
     Decreased POU5F1-GFP protein e  Decreased melanin production 

         1 MGI phenotypic allele for Prss58 (no phenotypes)

    Find genes that share phenotypes with PRSS58           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prss58tm1Lex for PRSS58

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS58
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRS58_HUMAN, Q8IYP2: Secreted (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with PRSS58           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS58
    Interactions:

        Search GeneGlobe Interaction Network for PRSS58

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with PRSS58           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS58 (PRS58)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRSS58 gene: 
    NM_001001317.3  

    Unigene Cluster for PRSS58:

    Protease, serine, 58
    Hs.98609  [show with all ESTs]
    Unigene Representative Sequence: AY358487
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000547058(uc003vxc.4) ENST00000552471(uc003vxb.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PRSS58
      QuantiFast Probe-based Assays in human, mouse, rat PRSS58

    Additional mRNA sequence: 

    AK122940.1 AY358487.1 BC035384.1 

    2 DOTS entries:

    DT.407804  DT.101979404 

    13 AceView cDNA sequences:

    BC035384 BI830119 BX119804 AA432317 AY358487 NM_001001317 AK122940 AW081788 
    AA428657 AI807285 AA625766 AI418557 AA927079 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS58 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTCTGTCT
    PRSS58 Expression
    About this image

    PRSS58 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS58 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98609
        Custom PCR Arrays for PRSS58
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS58

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS58 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss581 , 5 protease, serine 581, 5 75.93(n)1
    65.98(a)1
      6 (18.94 cM)5
    2327171  NM_175020.31  NP_778185.11 
     408952625 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    1 → many
    GL343276.1(1631121-1647585)


    ENSEMBL Gene Tree for PRSS58 (if available)
    TreeFam Gene Tree for PRSS58 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS58 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  
    PRSS32  KLK82  KLK32  
    Selected SIMAP similar genes for PRSS58 using alignment to 1 protein entry:     PRS58_HUMAN(see all similar genes):
    KLK6    KLK7    PRSS3    CTRB1    CTRB2    GZMK
    PRSS37    TRY8    PRSS1    CMA1    DF    GZMA
    KLK11    KLK5    KLK8    LOC136242    PRSS2    KLK13

    Find genes that share paralogs with PRSS58           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS58 (see all 265)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs782187601,2
    C,F--141951514(+) TCCTGC/AAACAT 1 -- ds50011Minor allele frequency- A:0.09EA 120
    rs78025441,2
    C,F,H--141951528(+) TGACCA/GGAATC 1 -- ds50014Minor allele frequency- G:0.00NS EA 420
    rs69506361,2
    C,F,A,H--141951601(+) TTTGCC/TCTCCC 1 -- ds500112Minor allele frequency- T:0.17NS EA WA NA CSA 645
    rs69701481,2
    C,F,A,H--141951633(+) TCTATA/TTAGAT 1 -- ds500114Minor allele frequency- T:0.20NS EA NA WA CSA 783
    rs1458226711,2
    C--141951636(+) ATATAC/GATCCC 1 -- ds50010--------
    rs1873424441,2
    --141951717(+) ATGTAG/TTAAAG 1 -- ds50010--------
    rs797877021,2
    C,F--141951726(+) AGGGTT/GTTGTA 1 -- ds50011Minor allele frequency- G:0.08EA 120
    rs69630121,2
    C,F,H--141951740(+) CAAATG/AGCTGT 1 -- ds500112Minor allele frequency- A:0.20NS EA WA NA CSA 788
    rs1164434181,2
    C,F--141951741(+) AAATGC/G/TCTGTG 1 -- ds50011WA 118
    rs69630351,2
    C,F,A,H--141951780(+) AATTCG/ATTAGA 1 -- ds500130Minor allele frequency- A:0.21NA NS EA WA CSA 2918

    HapMap Linkage Disequilibrium report for PRSS58 (141951958 - 141957878 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRSS58:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33962CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PRSS58
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS58

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS58 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PRSS58)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Scan of human genome reveals no new loci under ancient balancing selection. (PubMed id 16751668)1, 2 Bubb K.L.... Olson M.V. (Genetics 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1 Rowen L.... Hood L. (Science 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 136541 HGNC: 39125 AceView: TRY1 Ensembl:ENSG00000258223 euGenes: HUgn136541
    ECgene: PRSS58 H-InvDB: PRSS58

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS58 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS58 gene:
    Search GeneIP for patents involving PRSS58

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for PRSS58
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS58
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     Search Addgene for plasmids for PRSS58
      Search eBioscience for proteins for PRSS58
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      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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