PRSS58 Gene
protein-coding GIFtS: 39
GCID: GC07M141952
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protease, serine, 58
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Aliases
for PRSS58 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protease, Serine, 581 2 | | Serine Protease 582 | | TRYX31 2 3 | | Trypsin X32 | | TRY12 3 | | Trypsin-X33 | | PRSS12 | | EC 3.4.21.43 | | UNQ25402 | | Trypsin-X33 |
Export aliases for PRSS58 gene to outside databases |
Summaries
for PRSS58 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRSS58:
This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen genesare localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as atrypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. (provided by RefSeq, Jul 2008)
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Genomic Views
for PRSS58 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for PRSS58
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRSS58
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS58 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34PRSS58 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M141952: view genomic region
(about GC identifiers)
Start:
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141,951,963 bp from pter |
End:
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141,957,878 bp from pter |
Size:
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5,916 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 141,290,171-141,296,085 |
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Proteins
for PRSS58 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRS58_HUMAN, Q8IYP2 (See
protein sequence)Recommended Name: Serine protease 58 precursor Size: 241 amino acids; 27085 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B3KVJ6 D3DXD2Explore the universe of human proteins at neXtProt for PRSS58: NX_Q8IYP2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYP2
PRSS58 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001001317.1
ENSEMBL proteins: ENSP00000447588 ENSP00000446916
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
PRSS58 for ontologies About GeneDecksing
PRSS58 Antibody Products:
Assay Products for PRSS58: |
Protein
Domains /
Families
for PRSS58 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRSS58 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYP2ProtoNet protein and cluster: Q8IYP2 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: PRS58_HUMAN, Q8IYP2Similarity: Belongs to the peptidase S1 familySimilarity: Contains 1 peptidase S1 domain |
Function
for PRSS58 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PRS58_HUMAN, Q8IYP2Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -XaaEnzyme Number (IUBMB): EC 3.4.21.41
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS58 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS58
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PRSS58 (NM_001001317) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRSS58 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS58 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS58 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- |
PRSS58 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PRSS58:
Animal Models:
Mouse knock-out Prss58tm1Lex for PRSS58
1 MGI phenotypic allele  for Prss58 (no phenotypes)
PRSS58 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRSS58 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRSS58
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
PRSS58 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRSS58 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRSS58
Search CenterWatch for drugs/clinical trials and news about PRSS58 / PRS58
|
Transcripts
for PRSS58 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRSS58 gene: NM_001001317.3 Unigene Cluster for PRSS58: Protease, serine, 58 Hs.98609 [show with all ESTs]Unigene Representative Sequence: AY3584872 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000547058(uc003vxc.4) ENST00000552471(uc003vxb.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS58 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS58
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRSS58 (NM_001001317) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRSS58 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS58 |
Additional cDNA sequence: AK122940.1 AY358487.1 BC035384.1 2 DOTS entries: DT.407804 DT.101979404 13 AceView cDNA sequences: BC035384 BI830119 AA432317 AY358487 BX119804 NM_001001317 AA428657 AW081788 AK122940 AI807285 AA625766 AI418557 AA927079
GeneLoc Exon Structure
|
Expression
for PRSS58 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRSS58 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTCTGTCT
About this image
Genevestigator expression for PRSS58
SOURCE GeneReport for Unigene cluster: Hs.98609
SABiosciences Custom PCR Arrays for PRSS58
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS58
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRSS58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS58 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS58 |
Orthologs
for PRSS58 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PRSS58 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for PRSS58 (if available)
TreeFam Gene Tree for PRSS58 (if available) |
Paralogs
for PRSS58 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRSS58 gene
- KLK102 KLK12 KLK42 PRSS372 KLK112 KLK72 KLK142 KLK92
- KLK122 KLK132 KLK62 KLK22 KLK152 KLK52 PRSS12 PRSS32
- KLK32 KLK82
18/40 SIMAP similar genes for PRSS58 using alignment to 1 protein entry: PRS58_HUMAN(see all similar genes):KLK6 KLK7 TRY6 PRSS3 CTRB1 CTRB2
GZMK PRSS37 TRY8 PRSS1 CMA1 DF
GZMA KLK11 KLK5 KLK8 LOC136242 PRSS2
PRSS58 for paralogs About GeneDecksing
|
Genomic Variants
for PRSS58 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRSS58 (141951963 - 141957878 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRSS58: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for PRSS58 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for PRSS58 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRSS58 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PRSS58) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Scan of human genome reveals no new loci under ancient balancing selection. (PubMed id 16751668)1, 2 Bubb K.L.... Olson M.V. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1 Rowen L.... Hood L. (1996)
|
External Searches for PRSS58 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRSS58 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRSS58 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRSS58 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PRSS58 gene:
Search GeneIP for patents involving PRSS58
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRSS58 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PRSS58 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRSS58 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS58 | | | OriGene Protein Over-expression Lysate for PRSS58 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRSS58 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS58 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS58 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PRSS58 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PRSS58 | | OriGene Custom Protein Services for PRSS58 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRSS58 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRSS58 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS58 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS58 |
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 |  |  |  | |
| | | | Search Tocris compounds for PRSS58 |
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 | | | PRSS58 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS58 |
|  |  |  | | | | Search ThermoFisher Antibodies for PRSS58 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS58 |
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