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Aliases for PRSS58 Gene

Aliases for PRSS58 Gene

  • Protease, Serine 58 2 3 5
  • Trypsin-X3 3 4
  • TRYX3 3 4
  • TRY1 3 4
  • Serine Protease 58 3
  • EC 3.4.21.4 4
  • Trypsin X3 2
  • UNQ2540 3
  • PRSS1 3

External Ids for PRSS58 Gene

Previous GeneCards Identifiers for PRSS58 Gene

  • GC07M141952

Summaries for PRSS58 Gene

Entrez Gene Summary for PRSS58 Gene

  • This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as a trypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS58 Gene

PRSS58 (Protease, Serine 58) is a Protein Coding gene. Diseases associated with PRSS58 include Pancreas Disease. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS37.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS58 Gene

Genomics for PRSS58 Gene

Regulatory Elements for PRSS58 Gene

Enhancers for PRSS58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F141840 0.3 FANTOM5 26.1 +417.7 417667 0.1 PRSS37 PRSS58 MYL6P4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRSS58 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS58 Gene

Chromosome:
7
Start:
142,252,138 bp from pter
End:
142,258,058 bp from pter
Size:
5,921 bases
Orientation:
Minus strand

Genomic View for PRSS58 Gene

Genes around PRSS58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS58 Gene

Proteins for PRSS58 Gene

  • Protein details for PRSS58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYP2-PRS58_HUMAN
    Recommended name:
    Serine protease 58
    Protein Accession:
    Q8IYP2
    Secondary Accessions:
    • B3KVJ6
    • D3DXD2

    Protein attributes for PRSS58 Gene

    Size:
    241 amino acids
    Molecular mass:
    27085 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS58 Gene

Post-translational modifications for PRSS58 Gene

  • Glycosylation at Asn 156 and Asn 173
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS58 Gene

Domains & Families for PRSS58 Gene

Gene Families for PRSS58 Gene

Suggested Antigen Peptide Sequences for PRSS58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYP2

UniProtKB/Swiss-Prot:

PRS58_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS58: view

Function for PRSS58 Gene

Molecular function for PRSS58 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa.

Enzyme Numbers (IUBMB) for PRSS58 Gene

Gene Ontology (GO) - Molecular Function for PRSS58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS58: view
genes like me logo Genes that share phenotypes with PRSS58: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS58

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS58 Gene

Localization for PRSS58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS58 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS58 Gene COMPARTMENTS Subcellular localization image for PRSS58 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for PRSS58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRSS58: view

Pathways & Interactions for PRSS58 Gene

SuperPathways for PRSS58 Gene

No Data Available

Interacting Proteins for PRSS58 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000446916%0d%0a9606.ENSP00000273063%0d%0a9606.ENSP00000262418%0d%0a
Selected Interacting proteins: ENSP00000446916 Q8IYP2-PRS58_HUMAN for PRSS58 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PRSS58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS58: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS58 Gene

Transcripts for PRSS58 Gene

mRNA/cDNA for PRSS58 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS58 Gene

Protease, serine, 58:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS58 Gene

No ASD Table

Relevant External Links for PRSS58 Gene

GeneLoc Exon Structure for
PRSS58
ECgene alternative splicing isoforms for
PRSS58

Expression for PRSS58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRSS58 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS58 Gene

This gene is overexpressed in Testis (x51.9).

Protein differential expression in normal tissues from HIPED for PRSS58 Gene

This gene is overexpressed in Testis (36.1) and Ovary (32.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS58 Gene



Protein tissue co-expression partners for PRSS58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRSS58 Gene:

PRSS58

SOURCE GeneReport for Unigene cluster for PRSS58 Gene:

Hs.98609
genes like me logo Genes that share expression patterns with PRSS58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRSS58 Gene

Orthologs for PRSS58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS58 35
  • 100 (a)
OneToOne
LOC742071 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia LOC475522 34
  • 79.67 (n)
PRSS58 35
  • 70 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS58 34 35
  • 78.65 (n)
rat
(Rattus norvegicus)
Mammalia Prss58 34
  • 76.55 (n)
mouse
(Mus musculus)
Mammalia Prss58 34 16 35
  • 75.93 (n)
oppossum
(Monodelphis domestica)
Mammalia PRSS58 35
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 30 (a)
OneToMany
Species where no ortholog for PRSS58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS58 Gene

ENSEMBL:
Gene Tree for PRSS58 (if available)
TreeFam:
Gene Tree for PRSS58 (if available)

Paralogs for PRSS58 Gene

Paralogs for PRSS58 Gene

genes like me logo Genes that share paralogs with PRSS58: view

Variants for PRSS58 Gene

Sequence variations from dbSNP and Humsavar for PRSS58 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10248068 -- 142,259,337(+) agttg(A/C)caaat upstream-variant-2KB
rs10260153 -- 142,253,397(+) ACTGG(A/G)TTTCC intron-variant
rs10262675 -- 142,252,884(+) TTTGT(C/T)TTAAA intron-variant
rs10265544 -- 142,258,123(+) CTATC(C/T)CCCAC upstream-variant-2KB
rs10266031 -- 142,259,186(+) tcact(A/T)tagaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRSS58 Gene

Variant ID Type Subtype PubMed ID
esv33962 CNV gain+loss 17666407
nsv1018286 CNV gain 25217958
nsv1035111 CNV gain 25217958
nsv465131 CNV loss 19166990
nsv608591 CNV gain 21841781

Variation tolerance for PRSS58 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS58 Gene

Disorders for PRSS58 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRSS58 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pancreas disease
  • pancreatic diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRSS58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS58
genes like me logo Genes that share disorders with PRSS58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS58 Gene

Publications for PRSS58 Gene

  1. Scan of human genome reveals no new loci under ancient balancing selection. (PMID: 16751668) Bubb K.L. … Olson M.V. (Genetics 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for PRSS58 Gene

Sources for PRSS58 Gene

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