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Aliases for PRSS58 Gene

Aliases for PRSS58 Gene

  • Protease, Serine, 58 2 3
  • Trypsin-X3 3 4
  • TRYX3 3 4
  • TRY1 3 4
  • Serine Protease 58 3
  • EC 3.4.21.4 4
  • Trypsin X3 2
  • UNQ2540 3
  • PRSS1 3

External Ids for PRSS58 Gene

Previous GeneCards Identifiers for PRSS58 Gene

  • GC07M141952

Summaries for PRSS58 Gene

Entrez Gene Summary for PRSS58 Gene

  • This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as a trypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS58 Gene

PRSS58 (Protease, Serine, 58) is a Protein Coding gene. Among its related pathways are Disease and Degradation of the extracellular matrix. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK12.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS58 Gene

Genomics for PRSS58 Gene

Genomic Location for PRSS58 Gene

Start:
142,252,138 bp from pter
End:
142,258,058 bp from pter
Size:
5,921 bases
Orientation:
Minus strand

Genomic View for PRSS58 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS58 Gene

No data available for Regulatory Elements for PRSS58 Gene

Proteins for PRSS58 Gene

  • Protein details for PRSS58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYP2-PRS58_HUMAN
    Recommended name:
    Serine protease 58
    Protein Accession:
    Q8IYP2
    Secondary Accessions:
    • B3KVJ6
    • D3DXD2

    Protein attributes for PRSS58 Gene

    Size:
    241 amino acids
    Molecular mass:
    27085 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS58 Gene

Proteomics data for PRSS58 Gene at MOPED

Post-translational modifications for PRSS58 Gene

  • Glycosylation at Asn156 and Asn173
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS58 Gene

Domains for PRSS58 Gene

Gene Families for PRSS58 Gene

HGNC:
  • PRSS :Serine peptidases / Serine peptidases

Suggested Antigen Peptide Sequences for PRSS58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYP2

UniProtKB/Swiss-Prot:

PRS58_HUMAN :
  • Q8IYP2
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS58: view

Function for PRSS58 Gene

Molecular function for PRSS58 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa

Enzyme Numbers (IUBMB) for PRSS58 Gene

Gene Ontology (GO) - Molecular Function for PRSS58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PRSS58: view

Phenotypes for PRSS58 Gene

genes like me logo Genes that share phenotypes with PRSS58: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS58

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRSS58 Gene

Localization for PRSS58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS58 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for PRSS58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRSS58: view

No data available for Subcellular locations from COMPARTMENTS for PRSS58 Gene

Pathways for PRSS58 Gene

SuperPathways for PRSS58 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Degradation of the extracellular matrix
3 Disease
4 Metabolism
5 Pancreatic secretion
genes like me logo Genes that share pathways with PRSS58: view

Interacting Proteins for PRSS58 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000446916%0d%0a9606.ENSP00000273063%0d%0a9606.ENSP00000262418%0d%0a
Selected Interacting proteins: ENSP00000446916 for PRSS58 Gene via STRING

Gene Ontology (GO) - Biological Process for PRSS58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS58: view

Transcripts for PRSS58 Gene

mRNA/cDNA for PRSS58 Gene

(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS58 Gene

Protease, serine, 58:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS58

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PRSS58

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS58 Gene

No ASD Table

Relevant External Links for PRSS58 Gene

GeneLoc Exon Structure for
PRSS58
ECgene alternative splicing isoforms for
PRSS58

Expression for PRSS58 Gene

mRNA expression in normal human tissues for PRSS58 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS58 Gene

This gene is overexpressed in Testis (51.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRSS58 Gene

SOURCE GeneReport for Unigene cluster for PRSS58 Gene Hs.98609

genes like me logo Genes that share expressions with PRSS58: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRSS58 Gene

Orthologs for PRSS58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC742071 35
  • 99.72 (n)
  • 100 (a)
PRSS58 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS58 35
  • 78.65 (n)
  • 70.61 (a)
PRSS58 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC475522 35
  • 79.67 (n)
  • 70.12 (a)
PRSS58 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss58 35
  • 75.93 (n)
  • 65.98 (a)
Prss58 16
Prss58 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRSS58 36
  • 37 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss58 35
  • 76.55 (n)
  • 66.95 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
OneToMany
Species with no ortholog for PRSS58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS58 Gene

ENSEMBL:
Gene Tree for PRSS58 (if available)
TreeFam:
Gene Tree for PRSS58 (if available)

Paralogs for PRSS58 Gene

genes like me logo Genes that share paralogs with PRSS58: view

Variants for PRSS58 Gene

Sequence variations from dbSNP and Humsavar for PRSS58 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs879401 -- 142,256,437(-) CTCCC(C/G)CAACA intron-variant
rs983537 -- 142,254,077(+) TGACA(A/G)GTTTG intron-variant
rs983538 -- 142,254,387(+) TGAAA(C/T)ATGAG intron-variant
rs983539 -- 142,254,609(+) CTATC(A/G)CATTT intron-variant
rs985310 -- 142,258,034(+) CTCCT(C/G)TCTGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PRSS58 Gene

Variant ID Type Subtype PubMed ID
esv33962 CNV Gain+Loss 17666407

Relevant External Links for PRSS58 Gene

HapMap Linkage Disequilibrium report
PRSS58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS58 Gene

Disorders for PRSS58 Gene

No disorders were found for PRSS58 Gene.

No data available for UniProtKB/Swiss-Prot for PRSS58 Gene

Publications for PRSS58 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Scan of human genome reveals no new loci under ancient balancing selection. (PMID: 16751668) Bubb K.L. … Olson M.V. (Genetics 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for PRSS58 Gene

Sources for PRSS58 Gene

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