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Aliases for PRSS57 Gene

Aliases for PRSS57 Gene

  • Protease, Serine 57 2 3 5
  • Serine Protease 1-Like Protein 1 3 4
  • Protease, Serine-Like 1 2 3
  • PRSSL1 3 4
  • Protease, Serine, 57 3
  • EC 3.4.21.- 4
  • GLGL782 3
  • UNQ782 3
  • NSP4 3

External Ids for PRSS57 Gene

Previous HGNC Symbols for PRSS57 Gene

  • PRSSL1

Summaries for PRSS57 Gene

GeneCards Summary for PRSS57 Gene

PRSS57 (Protease, Serine 57) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is ELANE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS57 Gene

Genomics for PRSS57 Gene

Regulatory Elements for PRSS57 Gene

Enhancers for PRSS57 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS57 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS57 Gene

685,546 bp from pter
695,531 bp from pter
9,986 bases
Minus strand

Genomic View for PRSS57 Gene

Genes around PRSS57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS57 Gene

Proteins for PRSS57 Gene

  • Protein details for PRSS57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 57
    Protein Accession:
    Secondary Accessions:
    • B2RNW8

    Protein attributes for PRSS57 Gene

    283 amino acids
    Molecular mass:
    30334 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRSS57 Gene

neXtProt entry for PRSS57 Gene

Proteomics data for PRSS57 Gene at MOPED

Post-translational modifications for PRSS57 Gene

No Post-translational modifications

Other Protein References for PRSS57 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS57 Gene

Domains & Families for PRSS57 Gene

Gene Families for PRSS57 Gene

Suggested Antigen Peptide Sequences for PRSS57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS57: view

Function for PRSS57 Gene

Enzyme Numbers (IUBMB) for PRSS57 Gene

genes like me logo Genes that share phenotypes with PRSS57: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS57

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS57 Gene

Localization for PRSS57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS57 Gene


Subcellular locations from

Jensen Localization Image for PRSS57 Gene COMPARTMENTS Subcellular localization image for PRSS57 gene
Compartment Confidence
extracellular 4
cytosol 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PRSS57 Gene

Pathways & Interactions for PRSS57 Gene

SuperPathways for PRSS57 Gene

No Data Available

Interacting Proteins for PRSS57 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000327386 for PRSS57 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PRSS57 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRSS57 Gene

Drugs & Compounds for PRSS57 Gene

No Compound Related Data Available

Transcripts for PRSS57 Gene

mRNA/cDNA for PRSS57 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS57 Gene

Protease, serine, 57:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS57 Gene

No ASD Table

Relevant External Links for PRSS57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS57 Gene

mRNA expression in normal human tissues for PRSS57 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS57 Gene

This gene is overexpressed in Whole Blood (x38.8) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for PRSS57 Gene

This gene is overexpressed in Monocytes (35.0) and Cervix (31.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS57 Gene

SOURCE GeneReport for Unigene cluster for PRSS57 Gene Hs.245146

genes like me logo Genes that share expression patterns with PRSS57: view

Protein tissue co-expression partners for PRSS57 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRSS57 Gene

Orthologs for PRSS57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS57 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRSS57 35
  • 82.05 (n)
  • 79.12 (a)
PRSS57 36
  • 76 (a)
(Canis familiaris)
Mammalia PRSS57 35
  • 79.71 (n)
  • 77.9 (a)
PRSS57 36
  • 75 (a)
(Mus musculus)
Mammalia Prss57 35
  • 74.13 (n)
  • 73.75 (a)
Prss57 16
Prss57 36
  • 69 (a)
(Pan troglodytes)
Mammalia PRSS57 35
  • 97.76 (n)
  • 98.59 (a)
PRSS57 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Prss57 35
  • 74.29 (n)
  • 71.9 (a)
(Monodelphis domestica)
Mammalia PRSS57 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia PRSS57 36
  • 50 (a)
(Gallus gallus)
Aves PRSSL1 35
  • 56.97 (n)
  • 45.49 (a)
PRSS57 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497492 35
  • 49.49 (n)
  • 46.32 (a)
(Danio rerio)
Actinopterygii si:dkey-21e2.7 35
  • 47.42 (n)
  • 40.91 (a)
Species with no ortholog for PRSS57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS57 Gene

Gene Tree for PRSS57 (if available)
Gene Tree for PRSS57 (if available)

Paralogs for PRSS57 Gene

Paralogs for PRSS57 Gene

genes like me logo Genes that share paralogs with PRSS57: view

Variants for PRSS57 Gene

Sequence variations from dbSNP and Humsavar for PRSS57 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8102982 - 687,142(+) CTGGC(A/G)GCCTC reference, missense
rs12976484 -- 687,279(+) GCCCT(C/T)GTGAA intron-variant
rs7359915 -- 687,773(+) CCTCA(A/G)GACAA intron-variant
rs7359916 -- 687,799(+) CAGCC(A/C)GGGCC intron-variant
rs7359958 -- 687,835(+) CCCCT(C/T)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS57 Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
nsv910109 CNV Loss 21882294
nsv470101 CNV Loss 18288195
dgv3508n71 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3515n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3526n71 CNV Loss 21882294
dgv3528n71 CNV Loss 21882294
dgv3531n71 CNV Loss 21882294
nsv910224 CNV Loss 21882294
dgv3537n71 CNV Loss 21882294
dgv3541n71 CNV Loss 21882294
nsv910260 CNV Loss 21882294
esv2717767 CNV Deletion 23290073
esv2717768 CNV Deletion 23290073
esv2667208 CNV Deletion 23128226

Variation tolerance for PRSS57 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRSS57 Gene

Disorders for PRSS57 Gene

Relevant External Links for PRSS57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRSS57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS57 Gene

Publications for PRSS57 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease. (PMID: 25156428) Lin S.J. … Kirchhofer D. (Structure 2014) 3
  3. NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity. (PMID: 23904161) Perera N.C. … Jenne D.E. (J. Immunol. 2013) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PRSS57 Gene

Sources for PRSS57 Gene