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PRSS57 Gene

protein-coding   GIFtS: 37
GCID: GC19M000686

Protease, Serine, 57

(Previous names: protease, serine-like 1)
(Previous symbol: PRSSL1)
  Search for PRSS57
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 571 2     GLGL7822
PRSSL11 2 3     UNQ7822
Protease, Serine-Like 11 2     Serine Protease 572
Serine Protease 1-Like Protein 12 3     EC 3.4.21.-3

External Ids:    HGNC: 313971   Entrez Gene: 4006682   Ensembl: ENSG000001851987   UniProtKB: Q6UWY23   

Export aliases for PRSS57 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRSS57 Gene:
PRSS57 (protease, serine, 57) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is GZMH.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PRSS57
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS57 promoter sequence
   Search Chromatin IP Primers for PRSS57

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS57


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PRSS57 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS57 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M000686:  view genomic region     (about GC identifiers)

Start:
685,521 bp from pter      End:
695,461 bp from pter
Size:
9,941 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PRS57_HUMAN, Q6UWY2 (See protein sequence)
Recommended Name: Serine protease 57 precursor  
Size: 283 amino acids; 30334 Da
Secondary accessions: B2RNW8

Explore the universe of human proteins at neXtProt for PRSS57: NX_Q6UWY2

Explore proteomics data for PRSS57 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn129

  • See PRSS57 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_999875.1  
    ENSEMBL proteins: 
     ENSP00000327386  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q6UWY2

    ProtoNet protein and cluster: Q6UWY2

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRS57_HUMAN, Q6UWY2
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    PRSS57 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    PRSS57 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRSS57:
     Decreased Hepatitis C virus re  Wnt reporter downregulated 

         1 MGI phenotypic allele for Prss57 (no phenotypes)

    PRSS57 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prss57tm1Lex for PRSS57

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRS57_HUMAN, Q6UWY2: Secreted (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    PRSS57 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS57
    Interactions:

        Search GeneGlobe Interaction Network for PRSS57

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    PRSS57 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS57 (PRS57)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRSS57 gene: 
    NM_214710.3  

    Unigene Cluster for PRSS57:

    Protease, serine, 57
    Hs.245146  [show with all ESTs]
    Unigene Representative Sequence: AY358594
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329267(uc002lpl.1 uc010xfs.1)
    miRNA
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    Additional mRNA sequence: 

    AY358594.1 BC137161.1 BC144505.1 

    1 DOTS entry:

    DT.40238649 

    5 AceView cDNA sequences:

    AW075706 NM_214710 D19687 AY358594 AJ714526 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS57 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAGGGCAG
    PRSS57 Expression
    About this image

    PRSS57 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS57 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.245146
        Custom PCR Arrays for PRSS57
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS57

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS57 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss571 , 5 protease, serine 571, 5 74.13(n)1
    73.75(a)1
      10 (39.72 cM)5
    731061  NM_001042710.11  NP_001036175.11 
     797814765 
    chicken
    (Gallus gallus)
    Aves PRSSL11 protease, serine-like 1 56.97(n)
    45.49(a)
      420096  XM_418216.4  XP_418216.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004974921 serine protease 57-like 49.49(n)
    46.32(a)
      100497492  XM_002937384.2  XP_002937430.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-21e2.71 si:dkey-21e2.7 47.42(n)
    40.91(a)
      100034650  XM_003201043.2  XP_003201091.1 


    ENSEMBL Gene Tree for PRSS57 (if available)
    TreeFam Gene Tree for PRSS57 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS57 gene
    GZMH2  PRTN32  GZMK2  CTSG2  CFD2  ELANE2  CMA12  AZU12  
    GZMM2  GZMA2  GZMB2  
    Selected SIMAP similar genes for PRSS57 using alignment to 1 protein entry:     PRS57_HUMAN(see all similar genes):
    PRSSL1    GZMM    DF    F12    CFD    KLK5
    KLK4    PRSS1    CELA3A    GZMK    KLK13    KLK7
    KLK8    CELA1    CELA2A    GZMB    KLK14    KLK6

    PRSS57 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS57 (see all 454)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561466351,2
    C--615461(+) GCCAGA/TCCCTC 1 -- int10--------
    rs1506874551,2
    --615481(+) CTCGGA/CGCGGC 1 -- int10--------
    rs22857531,2
    C,H--615615(+) GGAACG/TGCATT 1 -- int15Minor allele frequency- T:0.01EA NS 1914
    rs22857541,2
    C,F,H--615716(+) GGCTGT/CGGACC 1 -- int117Minor allele frequency- C:0.38EA NS NA WA CSA 2268
    rs1397111021,2
    --615727(+) GAGCCA/GCGACA 1 -- int10--------
    rs129861101,2
    C,F--615740(+) AATGCC/TGGTGG 1 -- int15Minor allele frequency- T:0.12NA 128
    rs1858399721,2
    --615849(+) CTGCCC/TGTCCC 1 -- ut310--------
    rs1493481001,2
    C--615858(+) CCACCC/TCAACC 1 -- ut310--------
    rs129864031,2
    C,F--615896(+) AGCCAC/TGGAAC 1 -- ut31 ese35Minor allele frequency- T:0.12NA WA 244
    rs2002495791,2
    C--615971(+) TGGGGA/GCCTGG 2 P S mis10--------

    HapMap Linkage Disequilibrium report for PRSS57 (685521 - 695461 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRSS57 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717767CNV Deletion23290073
    esv2667208CNV Deletion23128226
    esv2717768CNV Deletion23290073
    nsv470101CNV Loss18288195
    dgv3526n71CNV Loss21882294
    dgv3528n71CNV Loss21882294
    dgv3515n71CNV Loss21882294
    dgv3541n71CNV Loss21882294
    nsv910109CNV Loss21882294
    nsv910260CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRSS57
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS57

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS57 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PRSS57)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping. (PubMed id 9533035)1 Polikoff D....Collins C.C. (Cytogenet. Cell Genet. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 400668 HGNC: 31397 AceView: PRSSL1 Ensembl:ENSG00000185198 euGenes: HUgn400668
    ECgene: PRSS57 H-InvDB: PRSS57

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS57 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS57 gene:
    Search GeneIP for patents involving PRSS57

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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