PRSS57 Gene
protein-coding GIFtS: 38
GCID: GC19M000686
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protease, serine, 57(Previous names: protease, serine-like 1 )
(Previous symbol: PRSSL1)
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Aliases
for PRSS57 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protease, Serine, 571 2 | | Serine Protease 1-Like Protein 12 3 | | PRSSL11 2 3 | | GLGL7822 | | UNQ7821 2 | | Serine Protease 572 | | Protease, Serine-Like 11 2 | | EC 3.4.21.-3 |
Export aliases for PRSS57 gene to outside databases |
Summaries
for PRSS57 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PRSS57 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for PRSS57
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRSS57
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS57 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3PRSS57 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M000686: view genomic region
(about GC identifiers)
Start:
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685,546 bp from pter |
End:
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695,461 bp from pter |
Size:
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9,916 bases |
Orientation:
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minus strand |
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Proteins
for PRSS57 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRS57_HUMAN, Q6UWY2 (See
protein sequence)Recommended Name: Serine protease 57 precursor Size: 283 amino acids; 30334 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B2RNW8Explore the universe of human proteins at neXtProt for PRSS57: NX_Q6UWY2
PRSS57 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_999875.1
ENSEMBL proteins: ENSP00000327386
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
PRSS57 for ontologies About GeneDecksing
PRSS57 Antibody Products:
Assay Products for PRSS57: |
Protein
Domains /
Families
for PRSS57 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRSS57 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UWY2ProtoNet protein and cluster: Q6UWY2 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: PRS57_HUMAN, Q6UWY2Similarity: Belongs to the peptidase S1 familySimilarity: Contains 1 peptidase S1 domain |
Function
for PRSS57 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.4.21.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS57 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS57 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PRSS57 (NM_214710) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRSS57 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS57 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS57 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- |
PRSS57 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PRSS57:
Animal Models:
Mouse knock-out Prss57tm1Lex for PRSS57
1 MGI phenotypic allele  for Prss57 (no phenotypes)
PRSS57 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRSS57 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRSS57
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
PRSS57 for ontologies About GeneDecksing
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Drugs & Compounds
for PRSS57 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRSS57
Search CenterWatch for drugs/clinical trials and news about PRSS57 / PRS57
|
Transcripts
for PRSS57 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRSS57 gene: NM_214710.3 Unigene Cluster for PRSS57: Protease, serine, 57 Hs.245146 [show with all ESTs]Unigene Representative Sequence: AY3585941 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000329267(uc002lpl.1 uc010xfs.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS57 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS57 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRSS57 (NM_214710) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRSS57 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS57 |
Additional cDNA sequence: AY358594.1 BC137161.1 BC144505.1 1 DOTS entry: DT.40238649 5 AceView cDNA sequences: AW075706 AY358594 NM_214710 D19687 AJ714526
GeneLoc Exon Structure
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Expression
for PRSS57 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRSS57 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAAGGGCAG
About this image
See PRSS57 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.245146
SABiosciences Custom PCR Arrays for PRSS57
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS57
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRSS57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS57 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS57 |
Orthologs
for PRSS57 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PRSS57 gene from 3/16 species (see all 16) About this table
ENSEMBL Gene Tree for PRSS57 (if available)
TreeFam Gene Tree for PRSS57 (if available) |
Paralogs
for PRSS57 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRSS57 gene
- PRTN32 GZMH2 GZMK2 CTSG2 CFD2 ELANE2 CMA12 AZU12
- GZMM2 GZMA2 GZMB2
18/49 SIMAP similar genes for PRSS57 using alignment to 1 protein entry: PRS57_HUMAN(see all similar genes):PRSSL1 GZMM DF F12 CFD KLK5
KLK4 KLK13 PRSS1 CELA3A GZMK KLK7
KLK8 CELA1 CELA2A GZMB KLK14 KLK6
PRSS57 for paralogs About GeneDecksing
|
Genomic Variants
for PRSS57 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRSS57 (685546 - 695461 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRSS57: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRSS57 |
|
Disorders
/ Diseases
for PRSS57 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for PRSS57 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRSS57 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PRSS57) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping. (PubMed id 9533035)1 Polikoff D....Collins C.C. (1997)
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External Searches for PRSS57 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing PRSS57 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRSS57 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRSS57 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PRSS57 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PRSS57 gene:
Search GeneIP for patents involving PRSS57
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRSS57 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PRSS57 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRSS57 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS57 | | | OriGene Protein Over-expression Lysate for PRSS57 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRSS57 | | OriGene 3'-UTR Clone for PRSS57 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS57 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS57 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PRSS57 | | OriGene Custom Protein Services for PRSS57 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRSS57 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRSS57 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS57 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS57 |
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 |  |  |  | |
| | | | Search Tocris compounds for PRSS57 |
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 | | | PRSS57 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS57 |
|  |  |  | | | | Search ThermoFisher Antibodies for PRSS57 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS57 |
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