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PRSS56 Gene

protein-coding   GIFtS: 35
GCID: GC02P233389

Protease, Serine, 56

  See PRSS56-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 561 2
MCOP62 5
Putative Serine Protease 562
Serine Protease 562
EC 3.4.21.-3

External Ids:    HGNC: 394331   Entrez Gene: 6469602   Ensembl: ENSG000002374127   OMIM: 6138585   UniProtKB: P0CW183   

Export aliases for PRSS56 gene to outside databases

Previous GC identifer: GC02U902398


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRSS56 Gene:
This gene encodes a protein that contains a peptidase S1 domain and possesses trypsin-like serine protease
activity. The encoded protein may play a role in eye development, and mutations in this gene are a cause of
autosomal recessive posterior microphthalmos. (provided by RefSeq, Dec 2011)

GeneCards Summary for PRSS56 Gene:
PRSS56 (protease, serine, 56) is a protein-coding gene. Diseases associated with PRSS56 include microphthalmia, isolated 6, and refractive error. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is ACR.

UniProtKB/Swiss-Prot: PRS56_HUMAN, P0CW18
Function: Serine protease required during eye development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PRSS56
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PRSS56

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS56


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

PRSS56 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS56 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P233389:  view genomic region     (about GC identifiers)

Start:
233,385,173 bp from pter      End:
233,390,426 bp from pter
Size:
5,254 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRS56_HUMAN, P0CW18 (See protein sequence)
Recommended Name: Serine protease 56 precursor  
Size: 603 amino acids; 64597 Da

Explore the universe of human proteins at neXtProt for PRSS56: NX_P0CW18

Post-translational modifications: 

  • Glycosylation2 at Asn97
  • REFSEQ proteins: NP_001182058.1  
    ENSEMBL proteins: 
     ENSP00000473410  

    PRSS56 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P0CW18

    ProtoNet protein and cluster: P0CW18

    UniProtKB/Swiss-Prot: PRS56_HUMAN, P0CW18
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PRSS56           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRS56_HUMAN, P0CW18
    Function: Serine protease required during eye development

         Enzyme Number (IUBMB): EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity ISS--
         
    Find genes that share ontologies with PRSS56           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prss56):
     nervous system  vision/eye 

    Find genes that share phenotypes with PRSS56           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS56
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    hsa-miR-9* hsa-miR-3143 hsa-miR-543 hsa-miR-646
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat PRSS56

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ISS--

    Find genes that share ontologies with PRSS56           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS56
    Interactions:

        Search GeneGlobe Interaction Network for PRSS56

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ISS--
    GO:0043010camera-type eye development IMP--

    Find genes that share ontologies with PRSS56           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS56 (PRS56)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRSS56 gene: 
    NM_001195129.1  

    Unigene Cluster for PRSS56:

    Protease, serine, 56
    Hs.570310  [show with all ESTs]
    Unigene Representative Sequence: NM_001195129
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449534(uc021vyh.1) ENST00000602410
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate PRSS56:
    hsa-miR-9* hsa-miR-3143 hsa-miR-543 hsa-miR-646
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse OriGene RNAi
    Predesigned siRNA for gene silencing in human, mouse, rat PRSS56
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PRSS56
      QuantiTect SYBR Green Assays in human, mouse, rat PRSS56
      QuantiFast Probe-based Assays in human, mouse, rat PRSS56

    3 DOTS entries:

    DT.120950285  DT.95069235  DT.99949395 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS56 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGGCCCC
    PRSS56 Expression
    About this image


    PRSS56 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
    PRSS56 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.570310

    UniProtKB/Swiss-Prot: PRS56_HUMAN, P0CW18
    Tissue specificity: Expressed neural retina, cornea, sclera and optic nerve

        Custom PCR Arrays for PRSS56
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS56

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRSS56 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss561 , 5 protease, serine 561, 5 80.31(n)1
    81.16(a)1
      1 (44.07 cM)5
    694531  NM_027084.11  NP_081360.11 
     871833135 
    chicken
    (Gallus gallus)
    Aves PRSS561 protease, serine, 56 62.33(n)
    54.41(a)
      424939  XM_422746.4  XP_422746.4 
    lizard
    (Anolis carolinensis)
    Reptilia PRSS566
    protease, serine, 56
    56(a)
    1 ↔ 1
    GL343304.1(248619-293623)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prss561 protease, serine, 56 55.87(n)
    51.3(a)
      101731690  XM_004914386.1  XP_004914443.1 
    zebrafish
    (Danio rerio)
    Actinopterygii PRSS566
    protease, serine, 56
    31(a)
    1 ↔ 1
    2(45110791-45121551) ENSDARG00000053158
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49141 CG4914 49.36(n)
    41.7(a)
      39597  NM_140454.3  NP_648711.1 


    ENSEMBL Gene Tree for PRSS56 (if available)
    TreeFam Gene Tree for PRSS56 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS56 gene
    ACR2  TMPRSS122  OVCH22  OVCH12  
    Selected SIMAP similar genes for PRSS56 using alignment to 2 protein entries:     PRS56_HUMAN (see all proteins) (see all similar genes):
    F12    CTRB2    CTRB1    DESC1    TMPRSS11E    TPSG1
    CTRL    DKFZp586F0824    DKFZp779M0222    ST14    TMPRSS11B    TMPRSS11F
    TMPRSS12    TMPRSS3    CELA3A    CELA2B    TMPRSS5    CTRC

    Find genes that share paralogs with PRSS56           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS56 (see all 105)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692284
    Microphthalmia, isolated, 6 (MCOP6)4--see VAR_0692282 G R mis40--------
    VAR_0650764
    Microphthalmia, isolated, 6 (MCOP6)4--see VAR_0650762 R G mis40--------
    VAR_0692304
    Microphthalmia, isolated, 6 (MCOP6)4--see VAR_0692302 P A mis40--------
    VAR_0692294
    Microphthalmia, isolated, 6 (MCOP6)4--see VAR_0692292 C R mis40--------
    VAR_0650774
    Microphthalmia, isolated, 6 (MCOP6)4--see VAR_0650772 W S mis40--------
    VAR_0692274
    Microphthalmia, isolated, 6 (MCOP6)4--see VAR_0692272 V F mis40--------
    VAR_0692264
    Microphthalmia, isolated, 6 (MCOP6)4--see VAR_0692262 G R mis40--------
    rs49730451,2
    C--232755899(+) GTTGTG/ATTACA 1 -- us2k12Minor allele frequency- A:0.18WA EA 122
    rs26978001,2
    C,F,H--232756052(-) GCACAG/AGTTAC 1 -- us2k122Minor allele frequency- A:0.20NS EA NA WA 2758
    rs1449734011,2
    C--232756057(+) CTGTGC/TGAGCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRSS56 (233385173 - 233390426 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PRSS56:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3211CNV Insertion18451855
    dgv4453n71CNV Loss21882294
    nsv527789CNV Loss19592680
    nsv875977CNV Loss21882294
    nsv875998CNV Loss21882294
    nsv522450CNV Loss19592680
    dgv4454n71CNV Loss21882294
    nsv821918CNV Gain20364138
    nsv876000CNV Gain21882294

    Human Gene Mutation Database (HGMD): PRSS56
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PRSS56
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS56

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613858   
    OMIM disorders: 613517  
    UniProtKB/Swiss-Prot: PRS56_HUMAN, P0CW18
  • Microphthalmia, isolated, 6 (MCOP6) [MIM:613517]: A developmental ocular disorder characterized by small
    malformed eyes. Clinical features are extreme hyperopia due to short axial length with essentially normal
    anterior segment, steep corneal curvatures, shallow anterior chamber, thick lenses, and thickened scleral wall.
    Palpebral fissures appear narrow because of relatively deep-set eyes, visual acuity is mildly to moderately
    reduced, and anisometropic or strabismic amblyopia is common. The fundus of the eye shows crowded optical disks,
    tortuous vessels, and an abnormal foveal avascular zone. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 5 diseases for PRSS56:    
    About MalaCards
    microphthalmia, isolated 6    refractive error    colchicine resistance    microphthalmia, isolated 2
    primary angle-closure glaucoma


    Find genes that share disorders with PRSS56           About GenesLikeMe


    Export disorders for PRSS56 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS56 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PRSS56)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Autosomal-recessive posterior microphthalmos is caused by mutations in PRSS56, a gene encoding a trypsin-like serine protease. (PubMed id 21397065)1, 2, 3 Gal A.... Rosenberg T. (Am. J. Hum. Genet. 2011)
    2. Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. (PubMed id 21532570)1, 2, 3 Nair K.S.... John S.W. (Nat. Genet. 2011)
    3. Mutations in a novel serine protease PRSS56 in families with nanophthalmos. (PubMed id 21850159)1, 2 Orr A.... Samuels M.E. (Mol. Vis. 2011)
    4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1, 2 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    5. Posterior microphthalmia and nanophthalmia in Tunisia caused by a founder c.1059_1066insC mutation of the PRSS56 gene. (PubMed id 23820083)1 Said M.B....Hmani-Aifa M. (Gene 2013)
    6. Biometric and molecular characterization of clinically diagnosed posterior microphthalmos. (PubMed id 23127749)1 Nowilaty S.R....Alkuraya F.S. (Am. J. Ophthalmol. 2013)
    7. Evaluation of PRSS56 in Chinese subjects with high hyperopia or primary angle-closure glaucoma. (PubMed id 24227917)1 Jiang D....Zhang Q. (Mol. Vis. 2013)
    8. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. (PubMed id 23396134)1 Verhoeven V.J....Hammond C.J. (Nat. Genet. 2013)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 646960 HGNC: 39433 Ensembl:ENSG00000237412 euGenes: HUgn646960 ECgene: PRSS56
    H-InvDB: PRSS56

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS56 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS56 gene:
    Search GeneIP for patents involving PRSS56

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   Browse OriGene RNAi products  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PRSS56  
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     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRSS56   OriGene Custom Protein Services for PRSS56  

     
     
     Block miRNA regulation of human, mouse, rat PRSS56 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PRSS56
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS56 Predesigned siRNA for gene silencing in human, mouse, rat PRSS56
     QuantiFast Probe-based Assays in human, mouse, rat PRSS56 QuantiTect SYBR Green Assays in human, mouse, rat PRSS56
     Custom PCR Arrays for PRSS56 Search Chromatin IP Primers for PRSS56
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PRSS56  Search GeneGlobe Interaction Network for PRSS56
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     GenScript Custom Purified and Recombinant Proteins Services for PRSS56 GenScript cDNA clones with any tag delivered in your preferred vector for PRSS56
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     Search Tocris compounds for PRSS56 (PRS56)
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     Novus Biologicals
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     Proteins for PRSS56
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     Browse ESI BIO Cell Lines and PureStem Progenitors for PRSS56
     Gene Synthesis
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for PRSS56
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     Search ThermoFisher Antibodies for PRSS56
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRSS56
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS56
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRSS56
     LSBio Antibodies in human, mouse, rat for PRSS56
    Customized transgenic rodents for:
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     Browse compounds at ApexBio
     Search Addgene for plasmids for PRSS56
      Search eBioscience for proteins for PRSS56
      Search eBioscience for elisas for PRSS56
      eBioscience FlowRNA Probe Sets
           
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