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Aliases for PRSS55 Gene

Aliases for PRSS55 Gene

  • Protease, Serine, 55 2 3
  • TSP1 3 4 6
  • Testis Serine Protease 1 3 4
  • T-SP1 3 4
  • Probable Serine Protease UNQ9391/PRO34284 3
  • Tryptophan/Serine Protease 3
  • Serine Protease 55 3
  • EC 3.4.21.- 4
  • UNQ9391 3
  • CT153 3

External Ids for PRSS55 Gene

Previous GeneCards Identifiers for PRSS55 Gene

  • GC08P010383
  • GC08P009313

Summaries for PRSS55 Gene

Entrez Gene Summary for PRSS55 Gene

  • This gene encodes a member of a group of membrane-anchored chymotrypsin (S1)-like serine proteases. The enocoded protein is primarily expressed in the Leydig and Sertoli cells of the testis and may be involved in male fertility. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for PRSS55 Gene

PRSS55 (Protease, Serine, 55) is a Protein Coding gene. Among its related pathways are p53 Signaling. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS54.

UniProtKB/Swiss-Prot for PRSS55 Gene

  • Probable serine protease.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS55 Gene

Genomics for PRSS55 Gene

Genomic Location for PRSS55 Gene

10,525,520 bp from pter
10,554,166 bp from pter
28,647 bases
Plus strand

Genomic View for PRSS55 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS55 Gene

No data available for Regulatory Elements for PRSS55 Gene

Proteins for PRSS55 Gene

  • Protein details for PRSS55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 55
    Protein Accession:
    Secondary Accessions:
    • E5RJX5

    Protein attributes for PRSS55 Gene

    352 amino acids
    Molecular mass:
    38856 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS55 Gene


neXtProt entry for PRSS55 Gene

Proteomics data for PRSS55 Gene at MOPED

Post-translational modifications for PRSS55 Gene

Other Protein References for PRSS55 Gene

Antibody Products

No data available for DME Specific Peptides for PRSS55 Gene

Domains for PRSS55 Gene

Gene Families for PRSS55 Gene

Suggested Antigen Peptide Sequences for PRSS55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS55: view

Function for PRSS55 Gene

Molecular function for PRSS55 Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease.

Enzyme Numbers (IUBMB) for PRSS55 Gene

Gene Ontology (GO) - Molecular Function for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PRSS55: view

Phenotypes for PRSS55 Gene

GenomeRNAi human phenotypes for PRSS55:
genes like me logo Genes that share phenotypes with PRSS55: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS55

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRSS55 Gene

Localization for PRSS55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS55 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for PRSS55 Gene COMPARTMENTS Subcellular localization image for PRSS55 gene
Compartment Confidence
extracellular 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRSS55: view

Pathways for PRSS55 Gene

SuperPathways for PRSS55 Gene

Superpath Contained pathways
1 p53 Signaling
genes like me logo Genes that share pathways with PRSS55: view

Pathways by source for PRSS55 Gene

1 Sino Biological pathway for PRSS55 Gene

Interacting Proteins for PRSS55 Gene

Gene Ontology (GO) - Biological Process for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS55: view

Transcripts for PRSS55 Gene

mRNA/cDNA for PRSS55 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS55 Gene

Protease, serine, 55:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS55

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS55 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: - -
SP2: -

Relevant External Links for PRSS55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS55 Gene

mRNA expression in normal human tissues for PRSS55 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS55 Gene

This gene is overexpressed in Testis (38.2).

Protein differential expression in normal tissues for PRSS55 Gene

This gene is overexpressed in Plasma (67.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PRSS55 Gene

SOURCE GeneReport for Unigene cluster for PRSS55 Gene Hs.591394

mRNA Expression by UniProt/SwissProt for PRSS55 Gene

Tissue specificity: Only detected in testis. Expressed in spermatogonia, spermatocytes, spermatids, Leydig and Sertoli cells. Expressed in prostate cancer and ovarian cancer (at protein level).
genes like me logo Genes that share expressions with PRSS55: view

Expression partners for PRSS55 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRSS55 Gene

Orthologs for PRSS55 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS55 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PRSS55 35
  • 80.18 (n)
  • 70.43 (a)
PRSS55 36
  • 66 (a)
(Mus musculus)
Mammalia Prss55 35
  • 72.37 (n)
  • 62.08 (a)
Prss55 16
Prss55 36
  • 57 (a)
(Pan troglodytes)
Mammalia PRSS55 35
  • 98.33 (n)
  • 97.35 (a)
PRSS55 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Prss55 35
  • 73.04 (n)
  • 62.42 (a)
(Bos Taurus)
Mammalia PRSS55 36
  • 61 (a)
(Monodelphis domestica)
Mammalia PRSS55 36
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia PRSS55 36
  • 34 (a)
(Gallus gallus)
Aves PRSS55 35
  • 55.73 (n)
  • 46.4 (a)
PRSS55 36
  • 40 (a)
(Anolis carolinensis)
Reptilia PRSS55 36
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta CLIPD3 35
  • 46.75 (n)
  • 41.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13318 36
  • 19 (a)
CG14990 36
  • 22 (a)
CG18477 36
  • 15 (a)
CG18478 36
  • 27 (a)
CG18557 36
  • 23 (a)
CG18563 36
  • 19 (a)
CG3117 36
  • 23 (a)
CG31780 36
  • 15 (a)
CG31827 36
  • 27 (a)
CG40160 36
  • 19 (a)
CG4259 36
  • 24 (a)
CG4793 36
  • 10 (a)
CG4998 36
  • 7 (a)
CG5390 36
  • 20 (a)
CG6639 36
  • 17 (a)
CG8586 36
  • 19 (a)
CG8738 36
  • 17 (a)
CG9377 36
  • 19 (a)
scaf 36
  • 10 (a)
Species with no ortholog for PRSS55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS55 Gene

Gene Tree for PRSS55 (if available)
Gene Tree for PRSS55 (if available)

Paralogs for PRSS55 Gene

Paralogs for PRSS55 Gene Pseudogenes for PRSS55 Gene

genes like me logo Genes that share paralogs with PRSS55: view

Variants for PRSS55 Gene

Sequence variations from dbSNP and Humsavar for PRSS55 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1133417 -- 10,538,568(+) GGAGA(G/T)AAGAA intron-variant, reference, missense
rs4077210 -- 10,538,905(+) GGACC(A/C)GGAGG intron-variant, downstream-variant-500B
rs4077605 -- 10,539,536(-) ATTTG(A/C)GTGGG intron-variant
rs4240649 -- 10,524,540(+) AAGGT(C/T)CAAAG upstream-variant-2KB
rs4240650 -- 10,524,955(+) GCTGA(A/C)AGCAT upstream-variant-2KB

Relevant External Links for PRSS55 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRSS55 Gene

Disorders for PRSS55 Gene

No disorders were found for PRSS55 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PRSS55 Gene

Publications for PRSS55 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. T-SP1: a novel serine protease-like protein predominantly expressed in testis. (PMID: 18844450) Neth P. … Jochum M. (Biol. Chem. 2008) 2 3 4
  3. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PMID: 23436708) Liu M. … Sha J. (Proteomics 2013) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4

Products for PRSS55 Gene

Sources for PRSS55 Gene

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