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Aliases for PRSS55 Gene

Aliases for PRSS55 Gene

  • Protease, Serine, 55 2 3
  • TSP1 3 4 6
  • Testis Serine Protease 1 3 4
  • T-SP1 3 4
  • Probable Serine Protease UNQ9391/PRO34284 3
  • Tryptophan/Serine Protease 3
  • Serine Protease 55 3
  • EC 3.4.21.- 4
  • UNQ9391 3
  • CT153 3

External Ids for PRSS55 Gene

Summaries for PRSS55 Gene

Entrez Gene Summary for PRSS55 Gene

  • This gene encodes a member of a group of membrane-anchored chymotrypsin (S1)-like serine proteases. The enocoded protein is primarily expressed in the Leydig and Sertoli cells of the testis and may be involved in male fertility. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for PRSS55 Gene

PRSS55 (Protease, Serine, 55) is a Protein Coding gene. Among its related pathways are p53 Signaling. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS54.

UniProtKB/Swiss-Prot for PRSS55 Gene

  • Probable serine protease.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS55 Gene

Genomics for PRSS55 Gene

Genomic Location for PRSS55 Gene

Start:
10,525,520 bp from pter
End:
10,554,166 bp from pter
Size:
28,647 bases
Orientation:
Plus strand

Genomic View for PRSS55 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS55 Gene

No data available for Regulatory Elements for PRSS55 Gene

Proteins for PRSS55 Gene

  • Protein details for PRSS55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWB4-PRS55_HUMAN
    Recommended name:
    Serine protease 55
    Protein Accession:
    Q6UWB4
    Secondary Accessions:
    • E5RJX5

    Protein attributes for PRSS55 Gene

    Size:
    352 amino acids
    Molecular mass:
    38856 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS55 Gene

Proteomics data for PRSS55 Gene at MOPED

Post-translational modifications for PRSS55 Gene

Other Protein References for PRSS55 Gene

No data available for DME Specific Peptides for PRSS55 Gene

Domains for PRSS55 Gene

Gene Families for PRSS55 Gene

HGNC:
  • PRSS :Serine peptidases / Serine peptidases

UniProtKB/Swiss-Prot:

PRS55_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • Q6UWB4
Family:
  • Belongs to the peptidase S1 family.:
    • Q6UWB4
genes like me logo Genes that share domains with PRSS55: view

Function for PRSS55 Gene

Molecular function for PRSS55 Gene

UniProtKB/Swiss-Prot Function: Probable serine protease.

Enzyme Numbers (IUBMB) for PRSS55 Gene

Gene Ontology (GO) - Molecular Function for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PRSS55: view

Phenotypes for PRSS55 Gene

GenomeRNAi human phenotypes for PRSS55:
genes like me logo Genes that share phenotypes with PRSS55: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRSS55 Gene

Localization for PRSS55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS55 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS55 Gene COMPARTMENTS Subcellular localization image for PRSS55 gene
Compartment Confidence
extracellular 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRSS55: view

Pathways for PRSS55 Gene

SuperPathways for PRSS55 Gene

Superpath Contained pathways
1 p53 Signaling
genes like me logo Genes that share pathways with PRSS55: view

Pathways by source for PRSS55 Gene

1 Sino Biological pathway for PRSS55 Gene

Interacting Proteins for PRSS55 Gene

Gene Ontology (GO) - Biological Process for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS55: view

Transcripts for PRSS55 Gene

mRNA/cDNA for PRSS55 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS55 Gene

Protease, serine, 55:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS55 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: - -
SP2: -

Relevant External Links for PRSS55 Gene

GeneLoc Exon Structure for
PRSS55
ECgene alternative splicing isoforms for
PRSS55

Expression for PRSS55 Gene

mRNA expression in normal human tissues for PRSS55 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS55 Gene

This gene is overexpressed in Testis (38.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PRSS55 Gene

SOURCE GeneReport for Unigene cluster for PRSS55 Gene Hs.591394

mRNA Expression by UniProt/SwissProt for PRSS55 Gene

Q6UWB4-PRS55_HUMAN
Tissue specificity: Only detected in testis. Expressed in spermatogonia, spermatocytes, spermatids, Leydig and Sertoli cells. Expressed in prostate cancer and ovarian cancer (at protein level).
genes like me logo Genes that share expressions with PRSS55: view

Orthologs for PRSS55 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS55 36
  • 98.33 (n)
  • 97.35 (a)
PRSS55 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS55 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS55 36
  • 80.18 (n)
  • 70.43 (a)
PRSS55 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss55 36
  • 72.37 (n)
  • 62.08 (a)
Prss55 16
Prss55 37
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRSS55 37
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS55 37
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss55 36
  • 73.04 (n)
  • 62.42 (a)
chicken
(Gallus gallus)
Aves PRSS55 36
  • 55.73 (n)
  • 46.4 (a)
PRSS55 37
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRSS55 37
  • 33 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta CLIPD3 36
  • 46.75 (n)
  • 41.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13318 37
  • 19 (a)
ManyToMany
CG14990 37
  • 22 (a)
ManyToMany
CG18477 37
  • 15 (a)
ManyToMany
CG18478 37
  • 27 (a)
ManyToMany
CG18557 37
  • 23 (a)
ManyToMany
CG18563 37
  • 19 (a)
ManyToMany
CG3117 37
  • 23 (a)
ManyToMany
CG31780 37
  • 15 (a)
ManyToMany
CG31827 37
  • 27 (a)
ManyToMany
CG40160 37
  • 19 (a)
ManyToMany
CG4259 37
  • 24 (a)
ManyToMany
CG4793 37
  • 10 (a)
ManyToMany
CG4998 37
  • 7 (a)
ManyToMany
CG5390 37
  • 20 (a)
ManyToMany
CG6639 37
  • 17 (a)
ManyToMany
CG8586 37
  • 19 (a)
ManyToMany
CG8738 37
  • 17 (a)
ManyToMany
CG9377 37
  • 19 (a)
ManyToMany
scaf 37
  • 10 (a)
ManyToMany
Species with no ortholog for PRSS55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS55 Gene

ENSEMBL:
Gene Tree for PRSS55 (if available)
TreeFam:
Gene Tree for PRSS55 (if available)

Paralogs for PRSS55 Gene

Paralogs for PRSS55 Gene

Pseudogenes.org Pseudogenes for PRSS55 Gene

genes like me logo Genes that share paralogs with PRSS55: view

Variants for PRSS55 Gene

Sequence variations from dbSNP and Humsavar for PRSS55 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1133417 -- 10,538,568(+) GGAGA(G/T)AAGAA intron-variant, reference, missense
rs4077210 -- 10,538,905(+) GGACC(A/C)GGAGG intron-variant, downstream-variant-500B
rs4077605 -- 10,539,536(-) ATTTG(A/C)GTGGG intron-variant
rs4240649 -- 10,524,540(+) AAGGT(C/T)CAAAG upstream-variant-2KB
rs4240650 -- 10,524,955(+) GCTGA(A/C)AGCAT upstream-variant-2KB

Relevant External Links for PRSS55 Gene

HapMap Linkage Disequilibrium report
PRSS55

No data available for Structural Variations from Database of Genomic Variants (DGV) for PRSS55 Gene

Disorders for PRSS55 Gene

No disorders were found for PRSS55 Gene.

No data available for UniProtKB/Swiss-Prot for PRSS55 Gene

Publications for PRSS55 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. T-SP1: a novel serine protease-like protein predominantly expressed in testis. (PMID: 18844450) Neth P. … Jochum M. (Biol. Chem. 2008) 2 3 4
  3. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PMID: 23436708) Liu M. … Sha J. (Proteomics 2013) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4

Products for PRSS55 Gene

Sources for PRSS55 Gene

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