Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRSS53 Gene

Aliases for PRSS53 Gene

  • Protease, Serine, 53 2 3
  • Polyserine Protease 3 3 4
  • Polyserase 3 2 3
  • Polyserase-3 3 4
  • POL3S 3 6
  • Serine Protease 53 3
  • EC 3.4.21.- 4
  • EDTP308 3
  • UNQ308 3

External Ids for PRSS53 Gene

Previous GeneCards Identifiers for PRSS53 Gene

  • GC16M028656

Summaries for PRSS53 Gene

GeneCards Summary for PRSS53 Gene

PRSS53 (Protease, Serine, 53) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

UniProtKB/Swiss-Prot for PRSS53 Gene

  • In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS53 Gene

Genomics for PRSS53 Gene

Genomic Location for PRSS53 Gene

31,083,424 bp from pter
31,089,628 bp from pter
6,205 bases
Minus strand

Genomic View for PRSS53 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS53 Gene

No data available for Regulatory Elements for PRSS53 Gene

Proteins for PRSS53 Gene

  • Protein details for PRSS53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 53
    Protein Accession:
    Secondary Accessions:

    Protein attributes for PRSS53 Gene

    553 amino acids
    Molecular mass:
    58410 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS53 Gene

Proteomics data for PRSS53 Gene at MOPED

Post-translational modifications for PRSS53 Gene

No Post-translational modifications

Other Protein References for PRSS53 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS53 Gene

Domains for PRSS53 Gene

Gene Families for PRSS53 Gene

Protein Domains for PRSS53 Gene

Suggested Antigen Peptide Sequences for PRSS53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 peptidase S1 domains.
  • Belongs to the peptidase S1 family.
  • Contains 2 peptidase S1 domains.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS53: view

Function for PRSS53 Gene

Molecular function for PRSS53 Gene

UniProtKB/Swiss-Prot Function:
In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.

Enzyme Numbers (IUBMB) for PRSS53 Gene

Gene Ontology (GO) - Molecular Function for PRSS53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PRSS53: view

miRNA for PRSS53 Gene

miRTarBase miRNAs that target PRSS53

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS53 Gene

Localization for PRSS53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS53 Gene


Subcellular locations from

Jensen Localization Image for PRSS53 Gene COMPARTMENTS Subcellular localization image for PRSS53 gene
Compartment Confidence
extracellular 5
cytosol 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRSS53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRSS53: view

Pathways for PRSS53 Gene

SuperPathways for PRSS53 Gene

No Data Available

Interacting Proteins for PRSS53 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000280606 for PRSS53 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PRSS53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS53: view

No data available for Pathways by source for PRSS53 Gene

Drugs for PRSS53 Gene

(3) PharmGKB related drug/compound annotations for PRSS53 Gene

Drug/compound Annotation
fluindione Clinical Annotation
phenprocoumon Clinical Annotation
warfarin Clinical Annotation
genes like me logo Genes that share compounds with PRSS53: view

Transcripts for PRSS53 Gene

mRNA/cDNA for PRSS53 Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS53 Gene

Protease, serine, 53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS53 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9

Relevant External Links for PRSS53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS53 Gene

mRNA expression in normal human tissues for PRSS53 Gene

Protein differential expression in normal tissues for PRSS53 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PRSS53 Gene

SOURCE GeneReport for Unigene cluster for PRSS53 Gene Hs.569575

mRNA Expression by UniProt/SwissProt for PRSS53 Gene

Tissue specificity: Predominantly detected in testis, liver, heart and ovary, as well as in several tumor cell lines.
genes like me logo Genes that share expressions with PRSS53: view

Expression partners for PRSS53 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRSS53 Gene

Orthologs for PRSS53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS53 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRSS53 35
  • 85.67 (n)
  • 86.16 (a)
PRSS53 36
  • 86 (a)
(Canis familiaris)
Mammalia PRSS53 35
  • 87.4 (n)
  • 86.08 (a)
PRSS53 36
  • 86 (a)
(Mus musculus)
Mammalia Prss53 35
  • 81.46 (n)
  • 81.16 (a)
Prss53 16
Prss53 36
  • 81 (a)
(Pan troglodytes)
Mammalia PRSS53 35
  • 99.28 (n)
  • 99.28 (a)
PRSS53 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Prss53 35
  • 80.45 (n)
  • 79.96 (a)
(Monodelphis domestica)
Mammalia PRSS53 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia PRSS53 36
  • 69 (a)
(Anolis carolinensis)
Reptilia PRSS53 36
  • 38 (a)
(Danio rerio)
Actinopterygii BX571714.1 36
  • 27 (a)
zgc:92313 36
  • 26 (a)
Species with no ortholog for PRSS53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS53 Gene

Gene Tree for PRSS53 (if available)
Gene Tree for PRSS53 (if available)

Paralogs for PRSS53 Gene

(18) SIMAP similar genes for PRSS53 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRSS53: view

Variants for PRSS53 Gene

Sequence variations from dbSNP and Humsavar for PRSS53 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2032916 -- 31,085,394(-) agtct(C/T)ttaac intron-variant
rs4313819 -- 31,087,228(+) TTGGG(C/G)TCAAG intron-variant
rs4316775 -- 31,087,222(+) gaact(C/T)ttggg intron-variant
rs4318224 -- 31,087,344(+) GTTTT(C/T)TGATT intron-variant
rs4468641 -- 31,085,555(+) CCAGG(A/C)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS53 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv833193 CNV Gain+Loss 17160897
dgv2672n71 CNV Loss 21882294
esv993244 CNV Deletion 20482838

Relevant External Links for PRSS53 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS53 Gene

Disorders for PRSS53 Gene

Relevant External Links for PRSS53

Genetic Association Database (GAD)

No disorders were found for PRSS53 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PRSS53 Gene

Publications for PRSS53 Gene

  1. Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain. (PMID: 16566820) Cal S. … Lopez-Otin C. (BMC Biochem. 2006) 2 3 4 23
  2. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N. … Foroud T. (Ann. Neurol. 2012) 3 48
  3. Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains. (PMID: 17485402) Cal S. … Lopez-Otin C. (Front. Biosci. 2007) 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3
  5. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PMID: 20953189) Stuart P.E. … Elder J.T. (Nat. Genet. 2010) 3

Products for PRSS53 Gene

Sources for PRSS53 Gene

Back to Top