Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRSS50 Gene

Aliases for PRSS50 Gene

  • Protease, Serine 50 2 3 5
  • Cancer/Testis Antigen 20 2 3 4
  • Testis-Specific Protease-Like Protein 50 3 4
  • Testes Specific Protease 50 2 3
  • Serine Protease 50 3 4
  • TSP50 3 4
  • CT20 3 4
  • Testicular Tissue Protein Li 210 3
  • Testes-Specific Protease 50 3
  • Protease, Serine, 50 3
  • EC 3.4.25.- 4

External Ids for PRSS50 Gene

Previous GeneCards Identifiers for PRSS50 Gene

  • GC03M046731

Summaries for PRSS50 Gene

GeneCards Summary for PRSS50 Gene

PRSS50 (Protease, Serine 50) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

UniProtKB/Swiss-Prot for PRSS50 Gene

  • May be involved in proteolysis through its threonine endopeptidase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS50 Gene

Genomics for PRSS50 Gene

Regulatory Elements for PRSS50 Gene

Enhancers for PRSS50 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS50 on UCSC Golden Path with GeneCards custom track

Promoters for PRSS50 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRSS50 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS50 Gene

46,712,116 bp from pter
46,812,574 bp from pter
100,459 bases
Minus strand

Genomic View for PRSS50 Gene

Genes around PRSS50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS50 Gene

Proteins for PRSS50 Gene

  • Protein details for PRSS50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable threonine protease PRSS50
    Protein Accession:

    Protein attributes for PRSS50 Gene

    385 amino acids
    Molecular mass:
    43088 Da
    Quaternary structure:
    No Data Available
    • DNA hypomethylation is accompanied by the expression of the gene in the testis.

neXtProt entry for PRSS50 Gene

Proteomics data for PRSS50 Gene at MOPED

Post-translational modifications for PRSS50 Gene

  • Glycosylation at Asn 133 and Asn 279
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS50 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TSP50

No data available for DME Specific Peptides for PRSS50 Gene

Domains & Families for PRSS50 Gene

Gene Families for PRSS50 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS50: view

Function for PRSS50 Gene

Molecular function for PRSS50 Gene

UniProtKB/Swiss-Prot Function:
May be involved in proteolysis through its threonine endopeptidase activity.

Enzyme Numbers (IUBMB) for PRSS50 Gene

Gene Ontology (GO) - Molecular Function for PRSS50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 NOT serine-type endopeptidase activity IBA --
genes like me logo Genes that share ontologies with PRSS50: view
genes like me logo Genes that share phenotypes with PRSS50: view

Animal Models for PRSS50 Gene

MGI Knock Outs for PRSS50:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS50

miRNA for PRSS50 Gene

miRTarBase miRNAs that target PRSS50

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRSS50 Gene

Localization for PRSS50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS50 Gene

Endoplasmic reticulum. Note=May also localize to cytoplasmic membranes.

Subcellular locations from

Jensen Localization Image for PRSS50 Gene COMPARTMENTS Subcellular localization image for PRSS50 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PRSS50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17283160
genes like me logo Genes that share ontologies with PRSS50: view

Pathways & Interactions for PRSS50 Gene

SuperPathways for PRSS50 Gene

No Data Available

Interacting Proteins for PRSS50 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000326598 for PRSS50 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PRSS50 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRSS50 Gene

Drugs & Compounds for PRSS50 Gene

No Compound Related Data Available

Transcripts for PRSS50 Gene

mRNA/cDNA for PRSS50 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS50 Gene

Protease, serine, 50:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS50 Gene

No ASD Table

Relevant External Links for PRSS50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS50 Gene

mRNA expression in normal human tissues for PRSS50 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS50 Gene

This gene is overexpressed in Testis (x15.1), Pituitary (x7.5), and Thyroid (x5.2).

Protein differential expression in normal tissues from HIPED for PRSS50 Gene

This gene is overexpressed in Testis (52.2) and Ovary (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS50 Gene

SOURCE GeneReport for Unigene cluster for PRSS50 Gene Hs.120365

mRNA Expression by UniProt/SwissProt for PRSS50 Gene

Tissue specificity: Testis specific. Differentially expressed in some breast cancer tissues.
genes like me logo Genes that share expression patterns with PRSS50: view

Protein tissue co-expression partners for PRSS50 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRSS50 Gene

Orthologs for PRSS50 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS50 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRSS50 35
  • 76.13 (n)
  • 64.35 (a)
PRSS50 36
  • 54 (a)
(Canis familiaris)
Mammalia PRSS50 35
  • 76.52 (n)
  • 63.92 (a)
PRSS50 36
  • 56 (a)
(Mus musculus)
Mammalia Prss50 35
  • 74.54 (n)
  • 60.83 (a)
Prss50 16
Prss50 36
  • 54 (a)
(Pan troglodytes)
Mammalia PRSS50 35
  • 99.57 (n)
  • 98.96 (a)
PRSS50 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100910205 35
  • 74.88 (n)
  • 62.31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
(Danio rerio)
Actinopterygii zgc:55888 36
  • 15 (a)
Species with no ortholog for PRSS50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS50 Gene

Gene Tree for PRSS50 (if available)
Gene Tree for PRSS50 (if available)

Paralogs for PRSS50 Gene

(10) SIMAP similar genes for PRSS50 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRSS50: view

Variants for PRSS50 Gene

Sequence variations from dbSNP and Humsavar for PRSS50 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs34788938 - 46,717,520(+) GGGTC(G/T)GCCAG reference, missense
rs35866901 - 46,717,452(+) GTCGA(C/T)TTTGC reference, missense
rs9814780 -- 46,712,087(+) AAACG(C/T)GGGGC downstream-variant-500B
rs7612286 -- 46,717,777(+) GCAGA(C/T)GTCCG reference, synonymous-codon
rs9815362 -- 46,712,486(+) TCCTG(C/T)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS50 Gene

Variant ID Type Subtype PubMed ID
dgv5127n71 CNV Gain 21882294
nsv516623 CNV Loss 19592680
dgv1455e1 CNV Complex 17122850
nsv428417 CNV Loss 18775914
dgv5128n71 CNV Loss 21882294
nsv876745 CNV Loss 21882294

Variation tolerance for PRSS50 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRSS50 Gene

Disorders for PRSS50 Gene

Relevant External Links for PRSS50

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRSS50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS50 Gene

Publications for PRSS50 Gene

  1. Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer. (PMID: 10397268) Yuan L. … Xu H.-P. (Cancer Res. 1999) 2 3 4 23 67
  2. Identification and characterization of the human testes-specific protease 50 gene promoter. (PMID: 18462069) Wang M. … Li Y.X. (DNA Cell Biol. 2008) 3 23
  3. Differential methylation of TSP50 and mTSP50 genes in different types of human tissues and mouse spermatic cells. (PMID: 18662669) Huang Y. … Xu H. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells. (PMID: 11782390) Shan J. … Xu H.P. (Cancer Res. 2002) 3 23
  5. TSP50 depends on its threonine protease activity and its interactions with TNF-I+-induced NF-I_B for its role in human cervical tumorigenesis. (PMID: 25312478) Yuan J. … Zhang G. (Cell Biochem. Biophys. 2015) 3

Products for PRSS50 Gene

Sources for PRSS50 Gene