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Aliases for PRSS50 Gene

Aliases for PRSS50 Gene

  • Protease, Serine, 50 2 3
  • Cancer/Testis Antigen 20 2 3 4
  • Testis-Specific Protease-Like Protein 50 3 4
  • Testes Specific Protease 50 2 3
  • Serine Protease 50 3 4
  • TSP50 3 4
  • CT20 3 4
  • Probable Threonine Protease PRSS50 3
  • Testes-Specific Protease 50 3
  • EC 3.4.25.- 4

External Ids for PRSS50 Gene

Summaries for PRSS50 Gene

GeneCards Summary for PRSS50 Gene

PRSS50 (Protease, Serine, 50) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

UniProtKB/Swiss-Prot for PRSS50 Gene

  • May be involved in proteolysis through its threonine endopeptidase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS50 Gene

Genomics for PRSS50 Gene

Genomic Location for PRSS50 Gene

Start:
46,712,116 bp from pter
End:
46,812,574 bp from pter
Size:
100,459 bases
Orientation:
Minus strand

Genomic View for PRSS50 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS50 Gene

No data available for Regulatory Elements for PRSS50 Gene

Proteins for PRSS50 Gene

  • Protein details for PRSS50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI38-TSP50_HUMAN
    Recommended name:
    Probable threonine protease PRSS50
    Protein Accession:
    Q9UI38
    Secondary Accessions:

    Protein attributes for PRSS50 Gene

    Size:
    385 amino acids
    Molecular mass:
    43088 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • DNA hypomethylation is accompanied by the expression of the gene in the testis

neXtProt entry for PRSS50 Gene

Proteomics data for PRSS50 Gene at MOPED

Post-translational modifications for PRSS50 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn133 and Asn279

Other Protein References for PRSS50 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS50 Gene

Domains for PRSS50 Gene

Gene Families for PRSS50 Gene

HGNC:
  • PRSS :Serine peptidases / Serine peptidases

Graphical View of Domain Structure for InterPro Entry

Q9UI38

UniProtKB/Swiss-Prot:

TSP50_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • Q9UI38
Family:
  • Belongs to the peptidase S1 family.:
    • Q9UI38
genes like me logo Genes that share domains with PRSS50: view

Function for PRSS50 Gene

Molecular function for PRSS50 Gene

UniProtKB/Swiss-Prot Function: May be involved in proteolysis through its threonine endopeptidase activity.

Enzyme Numbers (IUBMB) for PRSS50 Gene

Gene Ontology (GO) - Molecular Function for PRSS50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IMP 17283160
genes like me logo Genes that share ontologies with PRSS50: view
genes like me logo Genes that share phenotypes with PRSS50: view

miRNA for PRSS50 Gene

miRTarBase miRNAs that target PRSS50

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRSS50 Gene

Localization for PRSS50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS50 Gene

Endoplasmic reticulum. Note=May also localize to cytoplasmic membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS50 Gene COMPARTMENTS Subcellular localization image for PRSS50 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRSS50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17283160
GO:0005783 endoplasmic reticulum IDA 17283160
genes like me logo Genes that share ontologies with PRSS50: view

Pathways for PRSS50 Gene

SuperPathways for PRSS50 Gene

No Data Available

Interacting Proteins for PRSS50 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326598%0d%0a9606.ENSP00000358674%0d%0a
Selected Interacting proteins: ENSP00000326598 for PRSS50 Gene via STRING

Symbol External ID(s) Details
UBL4A

Gene Ontology (GO) - Biological Process for PRSS50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 17283160
genes like me logo Genes that share ontologies with PRSS50: view

No data available for Pathways by source for PRSS50 Gene

Transcripts for PRSS50 Gene

mRNA/cDNA for PRSS50 Gene

Unigene Clusters for PRSS50 Gene

Protease, serine, 50:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS50 Gene

No ASD Table

Relevant External Links for PRSS50 Gene

GeneLoc Exon Structure for
PRSS50
ECgene alternative splicing isoforms for
PRSS50

Expression for PRSS50 Gene

mRNA expression in normal human tissues for PRSS50 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS50 Gene

This gene is overexpressed in Testis (15.1), Pituitary (7.5), and Thyroid (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRSS50 Gene

SOURCE GeneReport for Unigene cluster for PRSS50 Gene Hs.120365

mRNA Expression by UniProt/SwissProt for PRSS50 Gene

Q9UI38-TSP50_HUMAN
Tissue specificity: Testis specific. Differentially expressed in some breast cancer tissues
genes like me logo Genes that share expressions with PRSS50: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRSS50 Gene

Orthologs for PRSS50 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS50 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS50 35
  • 99.57 (n)
  • 98.96 (a)
PRSS50 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS50 35
  • 76.13 (n)
  • 64.35 (a)
PRSS50 36
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS50 35
  • 76.52 (n)
  • 63.92 (a)
PRSS50 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss50 35
  • 74.54 (n)
  • 60.83 (a)
Prss50 16
Prss50 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910205 35
  • 74.88 (n)
  • 62.31 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:55888 36
  • 15 (a)
ManyToMany
Species with no ortholog for PRSS50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS50 Gene

ENSEMBL:
Gene Tree for PRSS50 (if available)
TreeFam:
Gene Tree for PRSS50 (if available)

Paralogs for PRSS50 Gene

Selected SIMAP similar genes for PRSS50 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRSS50: view

Variants for PRSS50 Gene

Sequence variations from dbSNP and Humsavar for PRSS50 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6806428 -- 46,715,772(+) TCGTG(C/T)CTCTC intron-variant
rs7612286 -- 46,717,777(+) GCAGA(C/T)GTCCG synonymous-codon, reference
rs7616942 -- 46,715,455(+) CCAGA(A/T)CAGCT intron-variant
rs7642015 -- 46,717,878(+) GCCCC(C/G)ACGAC utr-variant-5-prime
rs7649029 -- 46,711,865(+) CTGGC(A/G)GCCCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PRSS50 Gene

Variant ID Type Subtype PubMed ID
dgv5127n71 CNV Gain 21882294
nsv516623 CNV Loss 19592680
dgv1455e1 CNV Complex 17122850
nsv428417 CNV Loss 18775914
dgv5128n71 CNV Loss 21882294
nsv876745 CNV Loss 21882294

Relevant External Links for PRSS50 Gene

HapMap Linkage Disequilibrium report
PRSS50

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS50 Gene

Disorders for PRSS50 Gene

No disorders were found for PRSS50 Gene.

No data available for UniProtKB/Swiss-Prot for PRSS50 Gene

Publications for PRSS50 Gene

  1. Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer. (PMID: 10397268) Yuan L. … Xu H.-P. (Cancer Res. 1999) 2 3 4 23
  2. TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells. (PMID: 11782390) Shan J. … Xu H.P. (Cancer Res. 2002) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification and characterization of the human testes-specific protease 50 gene promoter. (PMID: 18462069) Wang M. … Li Y.X. (DNA Cell Biol. 2008) 3 23
  5. Differential methylation of TSP50 and mTSP50 genes in different types of human tissues and mouse spermatic cells. (PMID: 18662669) Huang Y. … Xu H. (Biochem. Biophys. Res. Commun. 2008) 3 23

Products for PRSS50 Gene

Sources for PRSS50 Gene

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