PRSS50 Gene
protein-coding GIFtS: 48
GCID: GC03M046731
|
|
protease, serine, 50
| |
Aliases
for PRSS50 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Protease, Serine, 501 2 | | Testis-Specific Protease-Like Protein 502 3 | | CT201 2 3 | | Probable Threonine Protease PRSS502 | | TSP501 2 3 | | Testes Specific Protease 502 | | Cancer/Testis Antigen 202 3 | | Testes-Specific Protease 502 | | Serine Protease 502 3 | | EC 3.4.25.-3 |
| External Ids: | HGNC: 179101 | Entrez Gene: 291222 | Ensembl: ENSG000002065497 | OMIM: 6079505 | UniProtKB: Q9UI383 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n387276 n387277 | |
Export aliases for PRSS50 gene to outside databases
Summaries
for PRSS50 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSP50_HUMAN, Q9UI38Function: May be involved in proteolysis through its threonine endopeptidase activity
|
Genomic Views
for PRSS50 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for PRSS50
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRSS50
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS50 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31PRSS50 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M046731: view genomic region
(about GC identifiers)
Start:
|
46,753,605 bp from pter |
End:
|
46,854,064 bp from pter |
Size:
|
100,460 bases |
Orientation:
|
minus strand |
ORGUL member locations:
Legend (see complete legend)
 |
Proteins
for PRSS50 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSP50_HUMAN, Q9UI38 (See
protein sequence)Recommended Name: Probable threonine protease PRSS50 precursor Size: 385 amino acids; 43088 Da
Subcellular location: Endoplasmic reticulum (Probable). Note=May also localize to cytoplasmic membranes
Miscellaneous: DNA hypomethylation is accompanied by the expression of the gene in the testis
Caution: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 310 which isreplaced by a ThrExplore the universe of human proteins at neXtProt for PRSS50: NX_Q9UI38
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UI38
PRSS50 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037402.1
ENSEMBL proteins: ENSP00000418875 ENSP00000326598
Human Recombinant Protein Products for PRSS50:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PRSS50 for ontologies About GeneDecksing
PRSS50 Antibody Products:
Assay Products for PRSS50: |
Protein
Domains /
Families
for PRSS50 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRSS50 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UI38ProtoNet protein and cluster: Q9UI38 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: TSP50_HUMAN, Q9UI38Similarity: Belongs to the peptidase S1 familySimilarity: Contains 1 peptidase S1 domain |
Function
for PRSS50 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TSP50_HUMAN, Q9UI38Function: May be involved in proteolysis through its threonine endopeptidase activity Enzyme Number (IUBMB): EC 3.4.25.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- | | GO:0004298 | threonine-type endopeptidase activity |
IMP | 17283160 |
PRSS50 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for PRSS50:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Prss50):
PRSS50 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS50 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS50 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: PRSS50 (NM_013270) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRSS50 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS50 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS50 |
|
Pathways & Interactions
for PRSS50 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRSS50
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for PRSS50 (ENSP000003265984) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
PRSS50 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRSS50 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRSS50
Search CenterWatch for drugs/clinical trials and news about PRSS50 / TSP50
|
Transcripts
for PRSS50 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRSS50 gene: NM_013270.4 Unigene Cluster for PRSS50: Protease, serine, 50 Hs.120365 [show with all ESTs]Unigene Representative Sequence: NM_0132702 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000460241(uc003cqe.1 uc003cqf.2 uc021wxe.1) ENST00000315170
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS50 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS50 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRSS50 (NM_013270) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRSS50 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS50 |
Additional cDNA sequence: AF100707.1 BC033016.1 BC037775.2 2 DOTS entries: DT.101018 DT.99930627 24/37 AceView cDNA sequences (see all 37): CA389034 BC037775 AK097666 CD358812 AI201486 CA389033 AI935051 AW139922 AI420868 BF593342 BU786187 NM_199183 AF100707 BN000137 AK092598 AK128390 BQ787879 AW183721 AI057441 AI653844 BI461252 CB052308 NM_013270 BC033016
GeneLoc Exon Structure
|
Expression
for PRSS50 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRSS50 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGGCACGT
About this image
See PRSS50 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRSS50
SOURCE GeneReport for Unigene cluster: Hs.120365
UniProtKB/Swiss-Prot: TSP50_HUMAN, Q9UI38Tissue specificity: Testis specific. Differentially expressed in some breast cancer tissues
SABiosciences Custom PCR Arrays for PRSS50
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS50
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRSS50 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS50 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS50 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS50 |
Orthologs
for PRSS50 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PRSS50 gene from 1/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
worm
(Caenorhabditis elegans) |
Secernentea |
try-16 |
TRYpsin-like Protease family member (try-1) |
26(a) |
1 → many |
II(4948148-4949480) |
ENSEMBL Gene Tree for PRSS50 (if available)
TreeFam Gene Tree for PRSS50 (if available) |
Paralogs
for PRSS50 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRSS50 gene
- PRSS462 PRSS552 PRSS482 PRSS222 PRSS272 PRSS212 PRSS452 TPSG12
- TPSD12 PRSS382 TPSAB12 PRSS532 PRSS422 PRSS362 PRSS332 KLKB12
- PRSS82 F112 OVCH12
11 SIMAP similar genes for PRSS50 using alignment to 1 protein entry: TSP50_HUMAN:PRSS45 PRSS21 PRSS22 PRSS27 CTRL PRSS33
TPSAB1 TPSB2 PRSS48 PRSS8 CTRB2
PRSS50 for paralogs About GeneDecksing
|
Genomic Variants
for PRSS50 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRSS50 (46753605 - 46854064 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PRSS50
1 CNV: 3428 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRSS50 |
|
Disorders
/ Diseases
for PRSS50 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRSS50 for disorders About GeneDecksing
OMIM gene information: 607950
OMIM disorders: --
3  diseases for PRSS50: About MalaCardsreflex sympathetic dystrophy breast cancer carcinoma
Export disorders for PRSS50 gene to outside databases
|
Publications
for PRSS50 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRSS50 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with PRSS50) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer. (PubMed id 10397268)1, 2, 3, 9 Yuan L.... Xu H.-P. (1999)
- TSP50 encodes a testis-specific protease and is negatively regulated by p53. (PubMed id 17283160)1, 2 Xu H.... Tian K. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification and characterization of the human testes-specific protease 50 gene promoter. (PubMed id 18462069)1, 9 Wang M....Li Y.X. (2008)
- TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells. (PubMed id 11782390)1, 9 Shan J....Xu H.P. (2002)
- Differential methylation of TSP50 and mTSP50 genes in different types of human tissues and mouse spermatic cells. (PubMed id 18662669)1, 9 Huang Y....Xu H. (2008)
- The threonine protease activity of testes-specific pro tease 50 (TSP50) is essential for its function in cell proliferation. (PubMed id 22574111)1 Li Y.Y....Li Y.X. (2012)
- High expression of testes-specific protease 50 is ass ociated with poor prognosis in colorectal carcinoma. (PubMed id 21765952)1 Zheng L....Li Q. (2011)
- Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (2010)
- Basic FGF downregulates TSP50 expression via the ERK/ Sp1 pathway. (PubMed id 20506264)1 Wang M....Li Y.X. (2010)
|
External Searches for PRSS50 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRSS50 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRSS50 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRSS50 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PRSS50 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PRSS50 gene:
Search GeneIP for patents involving PRSS50
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRSS50 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PRSS50 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRSS50 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS50 | | | OriGene Protein Over-expression Lysate for PRSS50 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRSS50 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS50 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS50 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | Search Tocris compounds for PRSS50 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | PRSS50 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS50 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for PRSS50 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS50 |
| |  | |
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