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PRSS50 Gene

protein-coding   GIFtS: 49
GCID: GC03M046731

Protease, Serine, 50

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Protease, Serine, 501 2     CT202 3
Cancer/Testis Antigen 201 2 3     TSP502 3
Testes Specific Protease 501 2     Probable Threonine Protease PRSS502
Serine Protease 502 3     Testes-Specific Protease 502
Testis-Specific Protease-Like Protein 502 3     EC 3.4.25.-3

External Ids:    HGNC: 179101   Entrez Gene: 291222   Ensembl: ENSG000002065497   OMIM: 6079505   UniProtKB: Q9UI383   
ORGUL members:         

Export aliases for PRSS50 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRSS50 Gene:
PRSS50 (protease, serine, 50) is a protein-coding gene. GO annotations related to this gene include threonine-type endopeptidase activity and serine-type endopeptidase activity. An important paralog of this gene is PRSS46.

UniProtKB/Swiss-Prot: TSP50_HUMAN, Q9UI38
Function: May be involved in proteolysis through its threonine endopeptidase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PRSS50
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS50 promoter sequence
   Search Chromatin IP Primers for PRSS50

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS50


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

PRSS50 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS50 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M046731:  view genomic region     (about GC identifiers)

Start:
46,753,605 bp from pter      End:
46,854,064 bp from pter
Size:
100,460 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for PRSS50

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSP50_HUMAN, Q9UI38 (See protein sequence)
Recommended Name: Probable threonine protease PRSS50 precursor  
Size: 385 amino acids; 43088 Da
Miscellaneous: DNA hypomethylation is accompanied by the expression of the gene in the testis
Caution: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 310 which is
replaced by a Thr

Explore the universe of human proteins at neXtProt for PRSS50: NX_Q9UI38

Explore proteomics data for PRSS50 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn133, Asn279
  • Modification sites at PhosphoSitePlus

  • See PRSS50 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037402.1  
    ENSEMBL proteins: 
     ENSP00000418875   ENSP00000326598  

    PRSS50 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PRSS50

     
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    antibodies-online proteins for PRSS50 (5 products) 

     
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    antibodies-online antibodies for PRSS50 (23 products) 

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    Cloud-Clone Corp. ELISAs for PRSS50
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    antibodies-online kits for PRSS50 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    3 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q9UI38

    ProtoNet protein and cluster: Q9UI38

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TSP50_HUMAN, Q9UI38
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PRSS50           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSP50_HUMAN, Q9UI38
    Function: May be involved in proteolysis through its threonine endopeptidase activity

         Enzyme Number (IUBMB): EC 3.4.25.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0004298threonine-type endopeptidase activity IMP17283160
         
    Find genes that share ontologies with PRSS50           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PRSS50:
     Increased cell number in G2M,  

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prss50):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  skeleton 

    Find genes that share phenotypes with PRSS50           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS50
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    miRNA
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    miRTarBase miRNAs that target PRSS50:
    hsa-mir-124-3p (MIRT022955)

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    Predesigned siRNA for gene silencing in human, mouse, rat PRSS50

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSP50_HUMAN, Q9UI38: Endoplasmic reticulum (Probable). Note=May also localize to cytoplasmic membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17283160
    GO:0005783endoplasmic reticulum IDA17283160

    Find genes that share ontologies with PRSS50           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS50
    Interactions:

        Search GeneGlobe Interaction Network for PRSS50

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PRSS50 (ENSP000003265984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1ENSP000003760764STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA17283160

    Find genes that share ontologies with PRSS50           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS50 (TSP50)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRSS50 gene: 
    NM_013270.4  

    Unigene Cluster for PRSS50:

    Protease, serine, 50
    Hs.120365  [show with all ESTs]
    Unigene Representative Sequence: NM_013270
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460241(uc003cqe.1 uc003cqf.2 uc021wxe.1) ENST00000315170

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PRSS50
      QuantiFast Probe-based Assays in human, mouse, rat PRSS50

    Additional mRNA sequence: 

    AF100707.1 BC033016.1 BC037775.2 

    2 DOTS entries:

    DT.101018  DT.99930627 

    Selected AceView cDNA sequences (see all 37):

    AF100707 AI935051 BU786187 BN000137 AW139922 AI201486 NM_199183 BF593342 
    CA389033 CD358812 CA389034 AK097666 BC037775 AI420868 AK128390 AW183721 
    BC033016 BQ787879 NM_013270 CB052308 BI915629 AK092598 AI057441 BI461252 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS50 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGCACGT
    PRSS50 Expression
    About this image

    PRSS50 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS50 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.120365

    UniProtKB/Swiss-Prot: TSP50_HUMAN, Q9UI38
    Tissue specificity: Testis specific. Differentially expressed in some breast cancer tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS50 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss501 , 5 protease, serine, 505
    protease, serine 501
    74.54(n)1
    60.83(a)1
      9 (60.79 cM)5
    2356311  NM_146227.41  NP_666339.21 
     1108579675 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    many ↔ many
    GL343287.1(1470248-1480509)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:558886
    zgc:55888
    15(a)
    many ↔ many
    4(8538926-8547751) ENSDARG00000016538


    ENSEMBL Gene Tree for PRSS50 (if available)
    TreeFam Gene Tree for PRSS50 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS50 gene
    PRSS462  PRSS482  PRSS222  PRSS272  TMPRSS92  PRSS212  PRSS452  TPSG12  
    TPSD12  PRSS382  TPSAB12  PRSS532  PRSS422  PRSS362  PRSS332  PRSS82  
    TPSB22  
    10 SIMAP similar genes for PRSS50 using alignment to 1 protein entry:     TSP50_HUMAN:
    PRSS45    PRSS21    PRSS22    PRSS27    CTRL    PRSS33
    TPSAB1    TPSB2    PRSS48    PRSS8

    Find genes that share paralogs with PRSS50           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS50 (see all 229)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898445471,2
    --46753325(+) CAGCCC/TAGACA 1 -- int10--------
    rs76490291,2
    C,F,A--46753355(+) CTGGCA/GGCCCC 1 -- int18Minor allele frequency- G:0.35NA WA CSA EA 366
    rs1477466061,2
    C--46753360(+) AGCCCC/TAGCTT 1 -- int10--------
    rs777188831,2
    C,F--46753375(+) CTGGGC/TGGTAT 1 -- int11Minor allele frequency- T:0.16WA 118
    rs1408798621,2
    --46753394(+) CCCCTC/TGATCA 1 -- int10--------
    rs1448400021,2
    C--46753435(+) CTCCAA/CCTTCT 1 -- int10--------
    rs1824078201,2
    --46753467(+) TGAATG/TGGGGA 1 -- int10--------
    rs98147801,2
    C,F,H--46753577(+) AAACGC/TGGGGC 1 -- int124Minor allele frequency- T:0.09NS EA NA WA CSA 2233
    rs1454981681,2
    C--46753592(+) GAGGCC/TGGGGA 1 -- int10--------
    rs738312001,2
    C--46753608(+) GAGGCA/GTGGAA 1 -- ut312Minor allele frequency- G:0.05WA 120

    HapMap Linkage Disequilibrium report for PRSS50 (46753605 - 46854064 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PRSS50:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876745CNV Loss21882294
    dgv5128n71CNV Loss21882294
    nsv428417CNV Loss18775914
    nsv516623CNV Loss19592680
    dgv5127n71CNV Gain21882294
    dgv1455e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607950    OMIM disorders: --


    Find genes that share disorders with PRSS50           About GenesLikeMe


    Export disorders for PRSS50 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS50 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with PRSS50)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer. (PubMed id 10397268)1, 2, 3, 9 Yuan L.... Xu H.-P. (Cancer Res. 1999)
    2. TSP50 encodes a testis-specific protease and is negatively regulated by p53. (PubMed id 17283160)1, 2 Xu H.... Tian K. (Cancer Res. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification and characterization of the human testes-specific protease 50 gene promoter. (PubMed id 18462069)1, 9 Wang M....Li Y.X. (DNA Cell Biol. 2008)
    5. TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells. (PubMed id 11782390)1, 9 Shan J....Xu H.P. (Cancer Res. 2002)
    6. Differential methylation of TSP50 and mTSP50 genes in different types of human tissues and mouse spermatic cells. (PubMed id 18662669)1, 9 Huang Y....Xu H. (Biochem. Biophys. Res. Commun. 2008)
    7. The threonine protease activity of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation. (PubMed id 22574111)1 Li Y.Y....Li Y.X. (PLoS ONE 2012)
    8. High expression of testes-specific protease 50 is associated with poor prognosis in colorectal carcinoma. (PubMed id 21765952)1 Zheng L....Li Q. (PLoS ONE 2011)
    9. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (BMB Rep 2010)
    10. Basic FGF downregulates TSP50 expression via the ERK/Sp1 pathway. (PubMed id 20506264)1 Wang M....Li Y.X. (J. Cell. Biochem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29122 HGNC: 17910 AceView: TSP50andTESSP5 Ensembl:ENSG00000206549 euGenes: HUgn29122
    ECgene: PRSS50 H-InvDB: PRSS50

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS50 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS50 gene:
    Search GeneIP for patents involving PRSS50

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     EMD Millipore genomic analysis products

      
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