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Aliases for PRSS48 Gene

Aliases for PRSS48 Gene

  • Protease, Serine 48 2 3 5
  • Epidermis-Specific Serine Protease-Like Protein 3 4
  • ESSPL 3 4
  • Testicular Tissue Protein Li 65 3
  • Protease, Serine, 48 3
  • EC 3.4.21.- 4

External Ids for PRSS48 Gene

Previous GeneCards Identifiers for PRSS48 Gene

  • GC04P152418
  • GC04P152198
  • GC04P147923

Summaries for PRSS48 Gene

GeneCards Summary for PRSS48 Gene

PRSS48 (Protease, Serine 48) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS48 Gene

Genomics for PRSS48 Gene

Regulatory Elements for PRSS48 Gene

Enhancers for PRSS48 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS48 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS48 Gene

Chromosome:
4
Start:
151,276,779 bp from pter
End:
151,291,611 bp from pter
Size:
14,833 bases
Orientation:
Plus strand

Genomic View for PRSS48 Gene

Genes around PRSS48 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS48 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS48 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS48 Gene

Proteins for PRSS48 Gene

  • Protein details for PRSS48 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTY5-PRS48_HUMAN
    Recommended name:
    Serine protease 48
    Protein Accession:
    Q7RTY5
    Secondary Accessions:
    • Q08E82
    • Q0VAD4

    Protein attributes for PRSS48 Gene

    Size:
    328 amino acids
    Molecular mass:
    35970 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD67963.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRSS48 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS48 Gene

Proteomics data for PRSS48 Gene at MOPED

Post-translational modifications for PRSS48 Gene

Other Protein References for PRSS48 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS48 Gene

Domains & Families for PRSS48 Gene

Gene Families for PRSS48 Gene

Suggested Antigen Peptide Sequences for PRSS48 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTY5

UniProtKB/Swiss-Prot:

PRS48_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS48: view

Function for PRSS48 Gene

Enzyme Numbers (IUBMB) for PRSS48 Gene

genes like me logo Genes that share phenotypes with PRSS48: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS48

CRISPR Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS48 Gene

Localization for PRSS48 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS48 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS48 Gene COMPARTMENTS Subcellular localization image for PRSS48 gene
Compartment Confidence
extracellular 4
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for PRSS48 Gene

Pathways & Interactions for PRSS48 Gene

SuperPathways for PRSS48 Gene

No Data Available

Interacting Proteins for PRSS48 Gene

Gene Ontology (GO) - Biological Process for PRSS48 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRSS48 Gene

Drugs & Compounds for PRSS48 Gene

No Compound Related Data Available

Transcripts for PRSS48 Gene

mRNA/cDNA for PRSS48 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS48 Gene

Protease, serine, 48:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS48 Gene

No ASD Table

Relevant External Links for PRSS48 Gene

GeneLoc Exon Structure for
PRSS48
ECgene alternative splicing isoforms for
PRSS48

Expression for PRSS48 Gene

mRNA expression in normal human tissues for PRSS48 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS48 Gene

This gene is overexpressed in Testis (x14.0).

SOURCE GeneReport for Unigene cluster for PRSS48 Gene Hs.651266

genes like me logo Genes that share expression patterns with PRSS48: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PRSS48 Gene

Orthologs for PRSS48 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS48 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PRSS48 35
  • 78.62 (n)
  • 68.25 (a)
PRSS48 36
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS48 36
  • 18 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRSS48 36
  • 38 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss48 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRSS48 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:112038 35
  • 52.17 (n)
  • 45.45 (a)
Species with no ortholog for PRSS48:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS48 Gene

ENSEMBL:
Gene Tree for PRSS48 (if available)
TreeFam:
Gene Tree for PRSS48 (if available)

Paralogs for PRSS48 Gene

Pseudogenes.org Pseudogenes for PRSS48 Gene

genes like me logo Genes that share paralogs with PRSS48: view

Variants for PRSS48 Gene

Sequence variations from dbSNP and Humsavar for PRSS48 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_042920 -
VAR_042921 -
VAR_042922 -

Structural Variations from Database of Genomic Variants (DGV) for PRSS48 Gene

Variant ID Type Subtype PubMed ID
nsv880262 CNV Gain 21882294
nsv881526 CNV Gain 21882294
esv1003225 CNV Insertion 20482838
esv1380112 CNV Insertion 17803354

Variation tolerance for PRSS48 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.97; 97.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS48 Gene

HapMap Linkage Disequilibrium report
PRSS48

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS48 Gene

Disorders for PRSS48 Gene

Relevant External Links for PRSS48

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS48

No disorders were found for PRSS48 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS48 Gene

Publications for PRSS48 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo. (PMID: 20379222) Sorrosal G. … MilA!n M. (EMBO Rep. 2010) 23
  4. Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus. (PMID: 19175361) Stec-Niemczyk J. … Dubin G. (Biochem. J. 2009) 23
  5. T-SP1: a novel serine protease-like protein predominantly expressed in testis. (PMID: 18844450) Neth P. … Jochum M. (Biol. Chem. 2008) 23

Products for PRSS48 Gene

Sources for PRSS48 Gene

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