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Aliases for PRSS46 Gene

Aliases for PRSS46 Gene

  • Protease, Serine, 46 2 3
  • Putative Serine Protease 46 3
  • Testis Serine Protease 6 3
  • EC 3.4.21.- 4
  • TESSP6 3

External Ids for PRSS46 Gene

Summaries for PRSS46 Gene

GeneCards Summary for PRSS46 Gene

PRSS46 (Protease, Serine, 46) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS46 Gene

Genomics for PRSS46 Gene

Genomic Location for PRSS46 Gene

Start:
46,719,583 bp from pter
End:
46,736,431 bp from pter
Size:
16,849 bases
Orientation:
Minus strand

Genomic View for PRSS46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS46 Gene

No data available for Regulatory Elements for PRSS46 Gene

Proteins for PRSS46 Gene

  • Protein details for PRSS46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E5RG02-PRS46_HUMAN
    Recommended name:
    Putative serine protease 46
    Protein Accession:
    E5RG02
    Secondary Accessions:

    Protein attributes for PRSS46 Gene

    Size:
    174 amino acids
    Molecular mass:
    19341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS46 Gene

Proteomics data for PRSS46 Gene at MOPED

Post-translational modifications for PRSS46 Gene

No Post-translational modifications

Other Protein References for PRSS46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS46 Gene

Domains for PRSS46 Gene

Gene Families for PRSS46 Gene

HGNC:
  • PRSS :Serine peptidases / Serine peptidases

Protein Domains for PRSS46 Gene

Graphical View of Domain Structure for InterPro Entry

E5RG02

UniProtKB/Swiss-Prot:

PRS46_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • E5RG02
Family:
  • Belongs to the peptidase S1 family.:
    • E5RG02
genes like me logo Genes that share domains with PRSS46: view

No data available for Suggested Antigen Peptide Sequences for PRSS46 Gene

Function for PRSS46 Gene

Enzyme Numbers (IUBMB) for PRSS46 Gene

Gene Ontology (GO) - Molecular Function for PRSS46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PRSS46: view

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRSS46 Gene

Localization for PRSS46 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PRSS46 Gene

Pathways for PRSS46 Gene

SuperPathways for PRSS46 Gene

No Data Available

Interacting Proteins for PRSS46 Gene

Gene Ontology (GO) - Biological Process for PRSS46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS46: view

No data available for Pathways by source for PRSS46 Gene

Transcripts for PRSS46 Gene

mRNA/cDNA for PRSS46 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS46 Gene

Protease, serine, 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS46 Gene

No ASD Table

Relevant External Links for PRSS46 Gene

GeneLoc Exon Structure for
PRSS46
ECgene alternative splicing isoforms for
PRSS46

Expression for PRSS46 Gene

mRNA expression in normal human tissues for PRSS46 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS46 Gene

This gene is overexpressed in Testis (32.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PRSS46 Gene

SOURCE GeneReport for Unigene cluster for PRSS46 Gene Hs.673244

genes like me logo Genes that share expressions with PRSS46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRSS46 Gene

Orthologs for PRSS46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 17 (a)
ManyToMany
PRSS46 35
  • 98.66 (n)
  • 97.13 (a)
cow
(Bos Taurus)
Mammalia LOC101907297 35
  • 78.04 (n)
  • 70.06 (a)
PRSS46 36
  • 36 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC609323 35
  • 81.94 (n)
  • 73.21 (a)
PRSS46 36
  • 34 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss46 35
  • 76.05 (n)
  • 64.37 (a)
Prss46 16
Prss46 36
  • 35 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Prss46 35
  • 76.15 (n)
  • 64.22 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 18 (a)
ManyToMany
-- 36
  • 17 (a)
ManyToMany
Species with no ortholog for PRSS46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS46 Gene

ENSEMBL:
Gene Tree for PRSS46 (if available)
TreeFam:
Gene Tree for PRSS46 (if available)

Paralogs for PRSS46 Gene

genes like me logo Genes that share paralogs with PRSS46: view

Variants for PRSS46 Gene

Sequence variations from dbSNP and Humsavar for PRSS46 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4683272 -- 46,729,111(-) GAAGC(C/T)TCCTA intron-variant
rs4683307 -- 46,722,035(-) gaatc(A/T)cattg intron-variant
rs4683308 -- 46,722,034(-) aatct(C/G)attgt intron-variant
rs6414431 -- 46,737,920(+) CAAGG(A/C)AATTA upstream-variant-2KB
rs6414432 -- 46,737,941(+) AATCA(A/G)ATTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRSS46 Gene

Variant ID Type Subtype PubMed ID
dgv5127n71 CNV Gain 21882294
nsv516623 CNV Loss 19592680
dgv1455e1 CNV Complex 17122850
nsv428417 CNV Loss 18775914
dgv5128n71 CNV Loss 21882294
nsv876745 CNV Loss 21882294
esv33334 CNV Gain 17666407

Relevant External Links for PRSS46 Gene

HapMap Linkage Disequilibrium report
PRSS46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS46 Gene

Disorders for PRSS46 Gene

No disorders were found for PRSS46 Gene.

No data available for UniProtKB/Swiss-Prot for PRSS46 Gene

Publications for PRSS46 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4

Products for PRSS46 Gene

Sources for PRSS46 Gene

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