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Aliases for PRSS46 Gene

Aliases for PRSS46 Gene

  • Protease, Serine 46 2 3 5
  • Testis Serine Protease 6 3
  • Protease, Serine, 46 3
  • EC 3.4.21.- 4
  • TESSP6 3

External Ids for PRSS46 Gene

Previous GeneCards Identifiers for PRSS46 Gene

  • GC03M046762
  • GC03M046803
  • GC03M046763

Summaries for PRSS46 Gene

GeneCards Summary for PRSS46 Gene

PRSS46 (Protease, Serine 46) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS46 Gene

Genomics for PRSS46 Gene

Genomic Location for PRSS46 Gene

46,719,583 bp from pter
46,736,431 bp from pter
16,849 bases
Minus strand

Genomic View for PRSS46 Gene

Genes around PRSS46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS46 Gene

No data available for Regulatory Elements for PRSS46 Gene

Proteins for PRSS46 Gene

  • Protein details for PRSS46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative serine protease 46
    Protein Accession:

    Protein attributes for PRSS46 Gene

    174 amino acids
    Molecular mass:
    19341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS46 Gene

Proteomics data for PRSS46 Gene at MOPED

Post-translational modifications for PRSS46 Gene

No Post-translational modifications

Other Protein References for PRSS46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS46 Gene

Domains & Families for PRSS46 Gene

Gene Families for PRSS46 Gene

Protein Domains for PRSS46 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS46: view

No data available for Suggested Antigen Peptide Sequences for PRSS46 Gene

Function for PRSS46 Gene

Enzyme Numbers (IUBMB) for PRSS46 Gene

Phenotypes for PRSS46 Gene

GenomeRNAi human phenotypes for PRSS46:
genes like me logo Genes that share phenotypes with PRSS46: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS46 Gene

Localization for PRSS46 Gene

Subcellular locations from

Jensen Localization Image for PRSS46 Gene COMPARTMENTS Subcellular localization image for PRSS46 gene
Compartment Confidence
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRSS46 Gene

Pathways & Interactions for PRSS46 Gene

SuperPathways for PRSS46 Gene

No Data Available

Interacting Proteins for PRSS46 Gene

Gene Ontology (GO) - Biological Process for PRSS46 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRSS46 Gene

Drugs & Compounds for PRSS46 Gene

No Compound Related Data Available

Transcripts for PRSS46 Gene

mRNA/cDNA for PRSS46 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS46 Gene

Protease, serine, 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS46 Gene

No ASD Table

Relevant External Links for PRSS46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS46 Gene

mRNA expression in normal human tissues for PRSS46 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS46 Gene

This gene is overexpressed in Testis (x32.5).

Protein differential expression in normal tissues from HIPED for PRSS46 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (58.7) and Adipocyte (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS46 Gene

SOURCE GeneReport for Unigene cluster for PRSS46 Gene Hs.673244

genes like me logo Genes that share expression patterns with PRSS46: view

Protein tissue co-expression partners for PRSS46 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRSS46 Gene

Orthologs for PRSS46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS46 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC101907297 35
  • 78.04 (n)
  • 70.06 (a)
PRSS46 36
  • 36 (a)
(Canis familiaris)
Mammalia LOC609323 35
  • 81.94 (n)
  • 73.21 (a)
PRSS46 36
  • 34 (a)
(Mus musculus)
Mammalia Prss46 35
  • 76.05 (n)
  • 64.37 (a)
Prss46 16
Prss46 36
  • 35 (a)
(Pan troglodytes)
Mammalia PRSS46 35
  • 98.66 (n)
  • 97.13 (a)
-- 36
  • 17 (a)
(Rattus norvegicus)
Mammalia Prss46 35
  • 76.15 (n)
  • 64.22 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 18 (a)
-- 36
  • 17 (a)
Species with no ortholog for PRSS46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS46 Gene

Gene Tree for PRSS46 (if available)
Gene Tree for PRSS46 (if available)

Paralogs for PRSS46 Gene

genes like me logo Genes that share paralogs with PRSS46: view

Variants for PRSS46 Gene

Sequence variations from dbSNP and Humsavar for PRSS46 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6414431 -- 46,737,920(+) CAAGG(A/C)AATTA upstream-variant-2KB
rs6414432 -- 46,737,941(+) AATCA(A/G)ATTCC upstream-variant-2KB
rs6763438 -- 46,737,498(+) CGAGG(C/T)TGTTC upstream-variant-2KB
rs6772081 -- 46,737,697(+) cagct(A/G)gaaac upstream-variant-2KB
rs6794689 -- 46,738,356(+) CCAAC(A/G)TAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRSS46 Gene

Variant ID Type Subtype PubMed ID
dgv5127n71 CNV Gain 21882294
nsv516623 CNV Loss 19592680
dgv1455e1 CNV Complex 17122850
nsv428417 CNV Loss 18775914
dgv5128n71 CNV Loss 21882294
nsv876745 CNV Loss 21882294
esv33334 CNV Gain 17666407

Variation tolerance for PRSS46 Gene

Gene Damage Index Score: 7.31; 81.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS46 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS46 Gene

Disorders for PRSS46 Gene

Relevant External Links for PRSS46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRSS46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS46 Gene

Publications for PRSS46 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for PRSS46 Gene

Sources for PRSS46 Gene

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