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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRSS45 Gene

protein-coding GIFtS: 41
GCID: GC03M046783

protease, serine, 45

Search for PRSS45
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protease, Serine, 45¹ ²
TESSP5¹ ² ³
Testis Serine Protease 5² ³
Putative Testis Serine Protease 5²
Serine Protease 45²
EC 3.4.21.-³

External Ids:	HGNC: 30717¹	Entrez Gene: 377047²	Ensembl: ENSG00000188086⁷	UniProtKB: Q7RTY3³

Export aliases for PRSS45 gene to outside databases

Previous GC identifer: GC03M046761

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for PRSS45
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS45

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31

PRSS45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS45 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M046783: view genomic region (about GC identifiers)

Start:	46,783,581 bp from pter	End:	46,854,048 bp from pter
Size:	70,468 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRS45_HUMAN, Q7RTY3 (See protein sequence)

Recommended Name: Serine protease 45

Size: 260 amino acids; 29329 Da

Secondary accessions: A3KN77

Alternative splicing: 2 isoforms: Q7RTY3-1 Q7RTY3-2

Explore the universe of human proteins at neXtProt for PRSS45: NX_Q7RTY3

PRSS45 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_954652.2

ENSEMBL proteins:

ENSP00000429264 ENSP00000401932

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRSS45 for domains About GeneDecksing

4 InterPro domains/families:

IPR001314 Peptidase_S1A

IPR001254 Peptidase_S1

IPR018114 Peptidase_S1_AS

IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry Q7RTY3

ProtoNet protein and cluster: Q7RTY3

2 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: PRS45_HUMAN, Q7RTY3

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 1 peptidase S1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Enzyme Number (IUBMB): EC 3.4.21.-¹

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--

PRSS45 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PRSS45:

Decreased homologous recombina

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PRSS45

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

PRSS45 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Browse Tocris compounds for PRSS45
Search CenterWatch for drugs/clinical trials and news about PRSS45 / PRS45

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for PRSS45 gene:

NM_199183.2

Unigene Cluster for PRSS45:

Protease, serine, 45

Hs.667712 [show with all ESTs]

Unigene Representative Sequence: NM_199183

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000423292(uc010hjl.3 uc011bam.2) ENST00000442359

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Additional cDNA sequence: BC133695.1

1 DOTS entry:

DT.101977049

24/37 AceView cDNA sequences (see all 37):

AW139922 CA389034 BF593342 BU786187 AF100707 AI420868 BN000137 AI201486

AK097666 NM_199183 CA389033 BC037775 CD358812 AI935051 AI057441 BE672200

BI915629 CB052308 BC033016 BQ787879 BI461252 AW183721 BU947395 NM_013270

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS45 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16a	·	16b	^	17	^	18	^	19	^	20
SP1:					-						-		-						-		-		-		-		-		-		-				-
SP2:													-
SP3:																																							-		-
SP4:

ECgene alternative splicing isoforms for PRSS45

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRSS45 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAAACTTG

About this image

PRSS45 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Glomerulus

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRSS45 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.667712

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PRSS45 gene from 1/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
fruit fly (Drosophila melanogaster)	Insecta	CG1632⁶	--	5(a)	possible ortholog	X(8146705-8166495)

ENSEMBL Gene Tree for PRSS45 (if available)
TreeFam Gene Tree for PRSS45 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRSS45 gene

PRSS46² PRSS55² PRSS48² PRSS22² PRSS27² PRSS21² TPSG1² TPSD1²

PRSS38² TPSAB1² PRSS53² PRSS50² PRSS42² PRSS36² PRSS33² KLKB1²

PRSS8² F11² OVCH1²

18/98 SIMAP similar genes for PRSS45 using alignment to 2 protein entries: PRS45_HUMAN (see all proteins) (see all similar genes):

PRSS44 PRSS8 PRSS33 PRSS42 TPSG1 PRSS27

TMPRSS11D KLK4 TMPRSS13 TPSAB1 CORIN PRSS50

TPSB2 tryptaseC CELA3A ACR DESC1 DKFZp586F0824

PRSS45 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60461823^1,2	C,F,	--	46783126(+)	`CACCAT/CGCCTG`	1	--	int¹		3		NA WA CSA	5
rs151118948^1,2		--	46783178(+)	`ATATAC/GCAAAA`	1	--	int¹		0	--	--	--	--
rs6807680^1,2	C,F,A,	--	46783229(+)	`GTCTAT/CTTTCT`	1	--	int¹		11		NA WA CSA EA	509
rs191069965^1,2		--	46783243(+)	`GGCTCA/GACTAT`	1	--	int¹		0	--	--	--	--
rs6805152^1,2	C,F,H,	--	46783247(+)	`cgactA/Ctgttt`	1	--	int¹		15		NS EA NA WA CSA	1411
rs6810260^1,2	C,F,A,H,	--	46783432(+)	`CAGACT/CTTTTC`	1	--	int¹		24		NS EA NA WA CSA	2484
rs182066517^1,2		--	46783538(+)	`CCCACA/GGCCAA`	1	--	int¹		0	--	--	--	--
rs4682827^1,2	C,H	--	46783548(-)	`GTCCCG/TGGGGT`	1	--	int¹		4		NS EA	412
rs4683270^1,2	A	--	46783549(-)	`AGTCCC/TTGGGG`	1	--	int¹		0	--	--	--	--
rs60294661^1,2	C,F,	--	46783556(+)	`GACTAC/TCCCAG`	1	--	int¹		7		WA CSA NA EA	364

HapMap Linkage Disequilibrium report for PRSS45 (46783581 - 46854048 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for PRSS45
8 CNVs: 91298 91297 79756 7411 36148 79754 3428 36147
1 Indel: 63459

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PRSS45 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PRSS45)

Utopia: connect your pdf to the dynamic
world of online information

Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)^{1, 2, 3} Puente X.S.... Lopez-Otin C. (2003)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 377047	HGNC: 30717	AceView: TSP50andTESSP5	Ensembl:ENSG00000188086	euGenes: HUgn377047
ECgene: PRSS45	H-InvDB: PRSS45

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRSS45	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PRSS45 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PRSS45 gene:
Search GeneIP for patents involving PRSS45

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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PRSS45 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for PRSS45

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS45

	SwitchGear 3'UTR luciferase reporter plasmids for PRSS45
	Browse SwitchGear Promoter luciferase reporter plasmids for PRSS45

Search ThermoFisher Antibodies for PRSS45

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS45

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PRSS45 gene at Home site.

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PRSS45 Gene

protease, serine, 45

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PRSS45 Gene

protease, serine, 45

Aliasesfor PRSS45 gene

Summariesfor PRSS45 gene

Genomic Viewsfor PRSS45 gene

Proteinsfor PRSS45 gene

Protein Domains /Familiesfor PRSS45 gene

Functionfor PRSS45 gene

Pathways & Interactionsfor PRSS45 gene

Drugs & Compoundsfor PRSS45 gene

Transcriptsfor PRSS45 gene

Expression for PRSS45 gene

Orthologsfor PRSS45 gene

Paralogsfor PRSS45 gene

Genomic Variantsfor PRSS45 gene

Disorders / Diseasesfor PRSS45 gene

Publicationsfor PRSS45 gene

External Searches for PRSS45 gene

Genome Databases showing PRSS45 gene

Other Databases showing PRSS45 gene

Specialized Databases showing PRSS45 gene

Intellectual Propertyfor PRSS45 gene

Productsfor PRSS45 gene

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Aliases
for PRSS45 gene

Summaries
for PRSS45 gene

Genomic Views
for PRSS45 gene

Proteins
for PRSS45 gene

Protein Domains /
Families
for PRSS45 gene

Function
for PRSS45 gene

Pathways & Interactions
for PRSS45 gene

Drugs & Compounds
for PRSS45 gene

Transcripts
for PRSS45 gene

Expression
for PRSS45 gene

Orthologs
for PRSS45 gene

Paralogs
for PRSS45 gene

Genomic Variants
for PRSS45 gene

Disorders / Diseases
for PRSS45 gene

Publications
for PRSS45 gene

Intellectual Property
for PRSS45 gene

Products
for PRSS45 gene