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Aliases for PRSS45 Gene

Aliases for PRSS45 Gene

  • Protease, Serine 45 2 3 5
  • Testis Serine Protease 5 2 3 4
  • TESSP5 3 4
  • Putative Testis Serine Protease 5 3
  • Serine Protease 45 3
  • EC 3.4.21.- 4

External Ids for PRSS45 Gene

Previous GeneCards Identifiers for PRSS45 Gene

  • GC03M046761
  • GC03M046783

Summaries for PRSS45 Gene

GeneCards Summary for PRSS45 Gene

PRSS45 (Protease, Serine 45) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is ENSG00000284672.

Additional gene information for PRSS45 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS45 Gene

Genomics for PRSS45 Gene

Regulatory Elements for PRSS45 Gene

Enhancers for PRSS45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H046844 1.4 Ensembl ENCODE dbSUPER 27.1 -101.1 -101127 2.6 KLF17 NFXL1 RAD21 GLIS2 EGR1 RCOR1 RUNX3 EGR2 SP3 ELF1 PRSS45 ALS2CL PTH1R MYL3 PRSS44 PRSS50 LRRC2 PRSS42
GH03H046848 1.1 Ensembl ENCODE dbSUPER 28.2 -104.5 -104485 1.7 CTCF PKNOX1 ZNF792 MAX RAD21 NR2F2 ZKSCAN8 EGR2 PRSS45 ALS2CL PTH1R MYL3 PRSS44 PRSS46 PRSS42
GH03H046952 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7 -212.3 -212261 9.6 HDGF PKNOX1 TBL1XR1 SIN3A YY1 FOS ATF7 ETV6 RUNX3 IKZF2 NBEAL2 CCDC12 PTH1R KLHL18 PRSS45 CSPG5 BOLA2P2 SETD2 GC03P046964 ENSG00000273682
GH03H046860 0.8 ENCODE dbSUPER 14.1 -116.9 -116888 1.4 PKNOX1 ESRRA NR2F1 NR2C1 SMAD4 NR2F6 RARA PRSS45 PTH1R PRSS42
GH03H046628 1.5 FANTOM5 Ensembl ENCODE 7.4 +115.3 115296 2.4 HDGF ATF1 RB1 NFXL1 ZBTB40 RAD21 CBX5 EGR1 ZNF143 ATF7 LTF ALS2CL TDGF1 RTP3 PRSS45 CCDC12 GC03P046626 GC03P046650
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRSS45 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS45 Gene

Genomic Locations for PRSS45 Gene
2,665 bases
Minus strand

Genomic View for PRSS45 Gene

Genes around PRSS45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS45 Gene

Proteins for PRSS45 Gene

  • Protein details for PRSS45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 45
    Protein Accession:
    Secondary Accessions:
    • A3KN77

    Protein attributes for PRSS45 Gene

    260 amino acids
    Molecular mass:
    29329 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS45 Gene


neXtProt entry for PRSS45 Gene

Post-translational modifications for PRSS45 Gene

Other Protein References for PRSS45 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS45 Gene

Domains & Families for PRSS45 Gene

Gene Families for PRSS45 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRSS45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS45: view

Function for PRSS45 Gene

Enzyme Numbers (IUBMB) for PRSS45 Gene

Phenotypes From GWAS Catalog for PRSS45 Gene

Gene Ontology (GO) - Molecular Function for PRSS45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS45: view

Phenotypes for PRSS45 Gene

genes like me logo Genes that share phenotypes with PRSS45: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS45 Gene

Localization for PRSS45 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS45 gene
Compartment Confidence
extracellular 3
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRSS45 Gene

Pathways & Interactions for PRSS45 Gene

SuperPathways for PRSS45 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS45: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS45 Gene

Drugs & Compounds for PRSS45 Gene

No Compound Related Data Available

Transcripts for PRSS45 Gene

mRNA/cDNA for PRSS45 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS45 Gene

Protease, serine, 45:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS45 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - - - - - - - -
SP2: -
SP3: - -

Relevant External Links for PRSS45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS45 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS45 Gene

This gene is overexpressed in Heart - Left Ventricle (x16.3), Thyroid (x4.8), and Muscle - Skeletal (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of PRSS45 Gene:


SOURCE GeneReport for Unigene cluster for PRSS45 Gene:

genes like me logo Genes that share expression patterns with PRSS45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS45 Gene

Orthologs for PRSS45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS45 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS45 33 34
  • 98.25 (n)
(Bos Taurus)
Mammalia PRSS45 33 34
  • 86.34 (n)
(Canis familiaris)
Mammalia PRSS45 33 34
  • 85.32 (n)
(Mus musculus)
Mammalia Prss45 33 16 34
  • 77.03 (n)
(Rattus norvegicus)
Mammalia Prss45 33
  • 75.26 (n)
(Monodelphis domestica)
Mammalia PRSS45 34
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
-- 34
  • 29 (a)
Species where no ortholog for PRSS45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS45 Gene

Gene Tree for PRSS45 (if available)
Gene Tree for PRSS45 (if available)

Paralogs for PRSS45 Gene

genes like me logo Genes that share paralogs with PRSS45: view

Variants for PRSS45 Gene

Sequence variations from dbSNP and Humsavar for PRSS45 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000047144 -- 46,743,068(+) CATGG(A/G)GTTGG reference, missense
rs1002943318 -- 46,745,859(+) TTTTT(C/T)TTTTT upstream-variant-2KB
rs1003277618 -- 46,742,148(+) CTTCT(A/T)GGCCA utr-variant-3-prime
rs1003406088 -- 46,746,100(+) AGCCT(A/C)TCTAC upstream-variant-2KB
rs1004281325 -- 46,743,607(+) CAAGG(C/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS45 Gene

Variant ID Type Subtype PubMed ID
nsv590179 CNV loss 21841781
nsv516623 CNV loss 19592680
nsv474207 CNV novel sequence insertion 20440878
nsv428417 CNV loss 18775914
nsv3798 CNV deletion 18451855
esv33334 CNV gain 17666407
esv28508 CNV loss 19812545
esv2759147 CNV loss 17122850
dgv4731n100 CNV loss 25217958
dgv4730n100 CNV loss 25217958

Variation tolerance for PRSS45 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.45; 82.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS45 Gene

Disorders for PRSS45 Gene

Relevant External Links for PRSS45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRSS45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS45 Gene

Publications for PRSS45 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for PRSS45 Gene

Sources for PRSS45 Gene

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