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Aliases for PRSS45 Gene

Aliases for PRSS45 Gene

  • Protease, Serine 45 2 3 5
  • Testis Serine Protease 5 2 3 4
  • TESSP5 3 4
  • Putative Testis Serine Protease 5 3
  • Protease, Serine, 45 3
  • EC 3.4.21.- 4

External Ids for PRSS45 Gene

Previous GeneCards Identifiers for PRSS45 Gene

  • GC03M046761
  • GC03M046783

Summaries for PRSS45 Gene

GeneCards Summary for PRSS45 Gene

PRSS45 (Protease, Serine 45) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS45 Gene

Genomics for PRSS45 Gene

Regulatory Elements for PRSS45 Gene

Promoters for PRSS45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRSS45 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS45 Gene

Chromosome:
3
Start:
46,742,091 bp from pter
End:
46,812,558 bp from pter
Size:
70,468 bases
Orientation:
Minus strand

Genomic View for PRSS45 Gene

Genes around PRSS45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS45 Gene

Proteins for PRSS45 Gene

  • Protein details for PRSS45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTY3-PRS45_HUMAN
    Recommended name:
    Serine protease 45
    Protein Accession:
    Q7RTY3
    Secondary Accessions:
    • A3KN77

    Protein attributes for PRSS45 Gene

    Size:
    260 amino acids
    Molecular mass:
    29329 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS45 Gene

Proteomics data for PRSS45 Gene at MOPED

Post-translational modifications for PRSS45 Gene

Other Protein References for PRSS45 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS45 Gene

Domains & Families for PRSS45 Gene

Gene Families for PRSS45 Gene

Suggested Antigen Peptide Sequences for PRSS45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTY3

UniProtKB/Swiss-Prot:

PRS45_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS45: view

Function for PRSS45 Gene

Enzyme Numbers (IUBMB) for PRSS45 Gene

Phenotypes for PRSS45 Gene

GenomeRNAi human phenotypes for PRSS45:
genes like me logo Genes that share phenotypes with PRSS45: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS45

CRISPR Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS45 Gene

Localization for PRSS45 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS45 Gene COMPARTMENTS Subcellular localization image for PRSS45 gene
Compartment Confidence
extracellular 3
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRSS45 Gene

Pathways & Interactions for PRSS45 Gene

SuperPathways for PRSS45 Gene

No Data Available

Interacting Proteins for PRSS45 Gene

Gene Ontology (GO) - Biological Process for PRSS45 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRSS45 Gene

Drugs & Compounds for PRSS45 Gene

No Compound Related Data Available

Transcripts for PRSS45 Gene

mRNA/cDNA for PRSS45 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS45 Gene

Protease, serine, 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS45 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - - - - - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for PRSS45 Gene

GeneLoc Exon Structure for
PRSS45
ECgene alternative splicing isoforms for
PRSS45

Expression for PRSS45 Gene

mRNA expression in normal human tissues for PRSS45 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS45 Gene

This gene is overexpressed in Heart - Left Ventricle (x16.3), Thyroid (x4.8), and Muscle - Skeletal (x4.8).

SOURCE GeneReport for Unigene cluster for PRSS45 Gene Hs.667712

genes like me logo Genes that share expression patterns with PRSS45: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PRSS45 Gene

Orthologs for PRSS45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS45 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRSS45 35
  • 86.34 (n)
  • 78.85 (a)
PRSS45 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS45 35
  • 85.32 (n)
  • 77.53 (a)
PRSS45 36
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss45 35
  • 77.03 (n)
  • 66.22 (a)
Prss45 16
Prss45 36
  • 46 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRSS45 35
  • 98.25 (n)
  • 97.37 (a)
PRSS45 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss45 35
  • 75.26 (n)
  • 67.42 (a)
oppossum
(Monodelphis domestica)
Mammalia PRSS45 36
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for PRSS45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS45 Gene

ENSEMBL:
Gene Tree for PRSS45 (if available)
TreeFam:
Gene Tree for PRSS45 (if available)

Paralogs for PRSS45 Gene

genes like me logo Genes that share paralogs with PRSS45: view

Variants for PRSS45 Gene

Sequence variations from dbSNP and Humsavar for PRSS45 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4075011 -- 46,743,641(+) GTGAA(A/G)GAATG intron-variant
rs4075012 -- 46,743,865(+) GCTCA(C/T)CTGAA intron-variant
rs4682827 -- 46,742,058(-) GTCCC(A/G/T)GGGGT downstream-variant-500B
rs6775814 -- 46,746,199(+) gcatt(G/T)ttttt upstream-variant-2KB
rs6442027 -- 46,745,820(+) GAGAA(C/T)GCAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRSS45 Gene

Variant ID Type Subtype PubMed ID
nsv516623 CNV Loss 19592680
dgv1455e1 CNV Complex 17122850
nsv428417 CNV Loss 18775914
nsv876745 CNV Loss 21882294
esv33334 CNV Gain 17666407
nsv3798 CNV Loss 18451855
nsv876746 CNV Loss 21882294
esv28508 CNV Loss 19812545
dgv5129n71 CNV Loss 21882294

Variation tolerance for PRSS45 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.45; 82.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS45 Gene

HapMap Linkage Disequilibrium report
PRSS45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS45 Gene

Disorders for PRSS45 Gene

Relevant External Links for PRSS45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS45

No disorders were found for PRSS45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS45 Gene

Publications for PRSS45 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PRSS45 Gene

Sources for PRSS45 Gene

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