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Aliases for PRSS45 Gene

Aliases for PRSS45 Gene

  • Protease, Serine, 45 2 3
  • Testis Serine Protease 5 2 3 4
  • TESSP5 3 4
  • Putative Testis Serine Protease 5 3
  • Serine Protease 45 3
  • EC 3.4.21.- 4

External Ids for PRSS45 Gene

Summaries for PRSS45 Gene

GeneCards Summary for PRSS45 Gene

PRSS45 (Protease, Serine, 45) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS45 Gene

Genomics for PRSS45 Gene

Genomic Location for PRSS45 Gene

Start:
46,742,091 bp from pter
End:
46,812,558 bp from pter
Size:
70,468 bases
Orientation:
Minus strand

Genomic View for PRSS45 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS45 Gene

No data available for Regulatory Elements for PRSS45 Gene

Proteins for PRSS45 Gene

  • Protein details for PRSS45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTY3-PRS45_HUMAN
    Recommended name:
    Serine protease 45
    Protein Accession:
    Q7RTY3
    Secondary Accessions:
    • A3KN77

    Protein attributes for PRSS45 Gene

    Size:
    260 amino acids
    Molecular mass:
    29329 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS45 Gene

Proteomics data for PRSS45 Gene at MOPED

Post-translational modifications for PRSS45 Gene

Other Protein References for PRSS45 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS45 Gene

Domains for PRSS45 Gene

Gene Families for PRSS45 Gene

HGNC:
  • PRSS :Serine peptidases / Serine peptidases

Suggested Antigen Peptide Sequences for PRSS45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTY3

UniProtKB/Swiss-Prot:

PRS45_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • Q7RTY3
Family:
  • Belongs to the peptidase S1 family.:
    • Q7RTY3
genes like me logo Genes that share domains with PRSS45: view

Function for PRSS45 Gene

Enzyme Numbers (IUBMB) for PRSS45 Gene

Gene Ontology (GO) - Molecular Function for PRSS45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PRSS45: view

Phenotypes for PRSS45 Gene

GenomeRNAi human phenotypes for PRSS45:
genes like me logo Genes that share phenotypes with PRSS45: view

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRSS45 Gene

Localization for PRSS45 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS45 Gene COMPARTMENTS Subcellular localization image for PRSS45 gene
Compartment Confidence
extracellular 3
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRSS45 Gene

Pathways for PRSS45 Gene

SuperPathways for PRSS45 Gene

No Data Available

Interacting Proteins for PRSS45 Gene

Gene Ontology (GO) - Biological Process for PRSS45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS45: view

No data available for Pathways by source for PRSS45 Gene

Transcripts for PRSS45 Gene

mRNA/cDNA for PRSS45 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS45 Gene

Protease, serine, 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS45 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - - - - - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for PRSS45 Gene

GeneLoc Exon Structure for
PRSS45
ECgene alternative splicing isoforms for
PRSS45

Expression for PRSS45 Gene

mRNA expression in normal human tissues for PRSS45 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS45 Gene

This gene is overexpressed in Heart - Left Ventricle (16.3), Thyroid (4.8), and Muscle - Skeletal (4.8).

SOURCE GeneReport for Unigene cluster for PRSS45 Gene Hs.667712

genes like me logo Genes that share expressions with PRSS45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for PRSS45 Gene

Orthologs for PRSS45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS45 35
  • 98.25 (n)
  • 97.37 (a)
PRSS45 36
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS45 35
  • 86.34 (n)
  • 78.85 (a)
PRSS45 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS45 35
  • 85.32 (n)
  • 77.53 (a)
PRSS45 36
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss45 35
  • 77.03 (n)
  • 66.22 (a)
Prss45 16
Prss45 36
  • 46 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRSS45 36
  • 28 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss45 35
  • 75.26 (n)
  • 67.42 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for PRSS45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS45 Gene

ENSEMBL:
Gene Tree for PRSS45 (if available)
TreeFam:
Gene Tree for PRSS45 (if available)

Paralogs for PRSS45 Gene

genes like me logo Genes that share paralogs with PRSS45: view

Variants for PRSS45 Gene

Sequence variations from dbSNP and Humsavar for PRSS45 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4075011 -- 46,743,641(+) GTGAA(A/G)GAATG intron-variant
rs4075012 -- 46,743,865(+) GCTCA(C/T)CTGAA intron-variant
rs4682827 -- 46,742,058(-) GTCCC(G/T)GGGGT downstream-variant-500B
rs4683270 -- 46,742,059(-) AGTCC(C/T)TGGGG downstream-variant-500B
rs6442027 -- 46,745,820(+) GAGAA(C/T)GCAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRSS45 Gene

Variant ID Type Subtype PubMed ID
nsv516623 CNV Loss 19592680
dgv1455e1 CNV Complex 17122850
nsv428417 CNV Loss 18775914
nsv876745 CNV Loss 21882294
esv33334 CNV Gain 17666407
nsv3798 CNV Loss 18451855
nsv876746 CNV Loss 21882294
esv28508 CNV Loss 19812545
dgv5129n71 CNV Loss 21882294

Relevant External Links for PRSS45 Gene

HapMap Linkage Disequilibrium report
PRSS45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS45 Gene

Disorders for PRSS45 Gene

No disorders were found for PRSS45 Gene.

No data available for UniProtKB/Swiss-Prot for PRSS45 Gene

Publications for PRSS45 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PRSS45 Gene

Sources for PRSS45 Gene

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