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PRSS45 Gene

protein-coding   GIFtS: 36
GCID: GC03M046783

Protease, Serine, 45

  Search for PRSS45
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 451 2
Testis Serine Protease 51 2 3
TESSP52 3
Putative Testis Serine Protease 52
Serine Protease 452
EC 3.4.21.-3

External Ids:    HGNC: 307171   Entrez Gene: 3770472   Ensembl: ENSG000001880867   UniProtKB: Q7RTY33   

Export aliases for PRSS45 gene to outside databases

Previous GC identifer: GC03M046761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRSS45 Gene:
PRSS45 (protease, serine, 45) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS46.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for PRSS45
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PRSS45

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

PRSS45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS45 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M046783:  view genomic region     (about GC identifiers)

Start:
46,783,581 bp from pter      End:
46,854,048 bp from pter
Size:
70,468 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PRS45_HUMAN, Q7RTY3 (See protein sequence)
Recommended Name: Serine protease 45  
Size: 260 amino acids; 29329 Da
Secondary accessions: A3KN77
Alternative splicing: 2 isoforms:  Q7RTY3-1   Q7RTY3-2   

Explore the universe of human proteins at neXtProt for PRSS45: NX_Q7RTY3

Explore proteomics data for PRSS45 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn55

  • See PRSS45 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_954652.2  
    ENSEMBL proteins: 
     ENSP00000429264   ENSP00000401932  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q7RTY3

    ProtoNet protein and cluster: Q7RTY3

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRS45_HUMAN, Q7RTY3
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    PRSS45 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    PRSS45 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PRSS45:
     Decreased homologous recombina 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    golgi apparatus1
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS45
    Interactions:

        Search GeneGlobe Interaction Network for PRSS45

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    PRSS45 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS45 (PRS45)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRSS45 gene: 
    NM_199183.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423292(uc010hjl.3 uc011bam.2) ENST00000442359
    miRNA
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    Selected AceView cDNA sequences (see all 37):

    AK097666 AI935051 CA389034 AI420868 BF593342 NM_199183 AF100707 AW139922 
    BN000137 BC037775 CA389033 AI201486 BU786187 CD358812 CB052308 AI653844 
    AI057441 BC033016 AK092598 NM_013270 BI915629 BI461252 BU947395 BQ787879 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS45    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
    SP1:              -                 -     -                 -     -     -     -     -     -     -           -                                                   
    SP2:                                      -                                                                                                                     
    SP3:                                                                                                                    -     -                                 
    SP4:                                                                                                                                                            


    ECgene alternative splicing isoforms for PRSS45

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAAACTTG
    PRSS45 Expression
    About this image

    PRSS45 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS45 Protein Expression
        Custom PCR Arrays for PRSS45
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS45 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss451 , 5 protease, serine, 455
    protease, serine 451
    77.03(n)1
    66.22(a)1
      9 (60.79 cM)5
    2604081  NM_153172.11  NP_694812.11 
     1108345885 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    30(a)
    29(a)
    many ↔ many
    many ↔ many
    GL343253.1(1843088-1847017)
    GL343287.1(1454751-1470659)


    ENSEMBL Gene Tree for PRSS45 (if available)
    TreeFam Gene Tree for PRSS45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS45 gene
    PRSS462  PRSS482  PRSS222  PRSS272  TMPRSS92  PRSS212  TPSG12  TPSD12  
    PRSS382  TPSAB12  PRSS532  PRSS502  PRSS422  PRSS362  PRSS332  PRSS82  
    TPSB22  
    Selected SIMAP similar genes for PRSS45 using alignment to 2 protein entries:     PRS45_HUMAN (see all proteins) (see all similar genes):
    PRSS44    PRSS8    KLK11    PRSS33    KLK2    PRSS42
    TPSG1    PRSS27    TMPRSS11D    KLK4    TMPRSS13    CORIN
    PRSS50    TPSAB1    TPSB2    tryptaseC    CELA3A    ACR

    PRSS45 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS45 (see all 145)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs604618231,2
    C,F--46783126(+) CACCAT/CGCCTG 1 -- int13Minor allele frequency- C:0.40NA WA CSA 5
    rs1511189481,2
    --46783178(+) ATATAC/GCAAAA 1 -- int10--------
    rs68076801,2
    C,F,A--46783229(+) gtctaT/Ctttct 1 -- int111Minor allele frequency- C:0.24NA WA CSA EA 509
    rs1910699651,2
    --46783243(+) GGCTCA/GACTAT 1 -- int10--------
    rs68051521,2
    C,F,H--46783247(+) cgactA/Ctgttt 1 -- int115Minor allele frequency- C:0.29NS EA NA WA CSA 1411
    rs68102601,2
    C,F,A,H--46783432(+) CAGACT/CTTTTC 1 -- int124Minor allele frequency- C:0.25NS EA NA WA CSA 2484
    rs1820665171,2
    --46783538(+) CCCACA/GGCCAA 1 -- int10--------
    rs46828271,2
    C,H--46783548(-) GTCCCG/TGGGGT 1 -- int14Minor allele frequency- T:0.00NS EA 412
    rs46832701,2
    A--46783549(-) AGTCCC/TTGGGG 1 -- int10--------
    rs602946611,2
    C,F--46783556(+) GACTAC/TCCCAG 1 -- int17Minor allele frequency- T:0.25WA CSA NA EA 364

    HapMap Linkage Disequilibrium report for PRSS45 (46783581 - 46854048 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PRSS45:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3798CNV Loss18451855
    dgv5129n71CNV Loss21882294
    nsv876746CNV Loss21882294
    esv28508CNV Loss19812545
    nsv876745CNV Loss21882294
    nsv428417CNV Loss18775914
    nsv516623CNV Loss19592680
    esv33334CNV Gain17666407
    dgv1455e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS45 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PRSS45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 2, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 377047 HGNC: 30717 AceView: TSP50andTESSP5 Ensembl:ENSG00000188086 euGenes: HUgn377047
    ECgene: PRSS45 H-InvDB: PRSS45

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS45 gene:
    Search GeneIP for patents involving PRSS45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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