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PRSS42 Gene

protein-coding   GIFtS: 40
GCID: GC03M046871

Protease, Serine, 42

  Search for PRSS42
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 421 2
Testis Serine Protease 21 2 3
TESSP22 3
Putative Testis Serine Protease 22
Serine Protease 422
EC 3.4.21.-3

External Ids:    HGNC: 307161   Entrez Gene: 3399062   Ensembl: ENSG000001780557   UniProtKB: Q7Z5A43   

Export aliases for PRSS42 gene to outside databases

Previous GC identifer: GC03M046847


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRSS42 Gene:
PRSS42 (protease, serine, 42) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS46.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PRSS42
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS42 promoter sequence
   Search Chromatin IP Primers for PRSS42

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

PRSS42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS42 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M046871:  view genomic region     (about GC identifiers)

Start:
46,871,032 bp from pter      End:
46,875,585 bp from pter
Size:
4,554 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PRS42_HUMAN, Q7Z5A4 (See protein sequence)
Recommended Name: Serine protease 42 precursor  
Size: 293 amino acids; 32006 Da

Explore the universe of human proteins at neXtProt for PRSS42: NX_Q7Z5A4

Explore proteomics data for PRSS42 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn141, Asn177, Asn276

  • See PRSS42 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_874361.1  
    ENSEMBL proteins: 
     ENSP00000401581   ENSP00000401701  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z5A4

    ProtoNet protein and cluster: Q7Z5A4

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRS42_HUMAN, Q7Z5A4
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    PRSS42 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    PRSS42 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PRSS42:
     Increased gamma-H2AX phosphory 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRS42_HUMAN, Q7Z5A4: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    PRSS42 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS42
    Interactions:

        Search GeneGlobe Interaction Network for PRSS42

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    PRSS42 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS42 (PRS42)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRSS42 gene: 
    NM_182702.1  

    Unigene Cluster for PRSS42:

    Protease, serine, 42
    Hs.585127  [show with all ESTs]
    Unigene Representative Sequence: AK092703
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447340(uc003cqj.3) ENST00000429665(uc011bap.2)
    miRNA
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    Additional mRNA sequence: 

    AJ544583.1 AK092703.1 

    2 DOTS entries:

    DT.100008247  DT.101976139 

    6 AceView cDNA sequences:

    NM_182702 AJ544583 BU196531 F36354 AX747680 AK092703 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS42    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:        -                                       
    SP2:              -           -     -               


    ECgene alternative splicing isoforms for PRSS42

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCACCAG
    PRSS42 Expression
    About this image


    PRSS42 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Testis (Reproductive System)
    PRSS42 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS42 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585127
        Custom PCR Arrays for PRSS42
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS42 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss421 , 5 protease, serine, 425
    protease, serine 421
    68.4(n)1
    56.75(a)1
      9 (60.79 cM)5
    2356281  NM_153099.11  NP_694739.11 
     1107981855 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    32(a)
    31(a)
    many ↔ many
    many ↔ many
    GL343253.1(1843088-1847017)
    GL343287.1(1454751-1470659)


    ENSEMBL Gene Tree for PRSS42 (if available)
    TreeFam Gene Tree for PRSS42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS42 gene
    PRSS462  PRSS482  PRSS222  PRSS272  TMPRSS92  PRSS212  PRSS452  TPSG12  
    TPSD12  PRSS382  TPSAB12  PRSS532  PRSS502  PRSS362  PRSS332  PRSS82  
    TPSB22  
    Selected SIMAP similar genes for PRSS42 using alignment to 2 protein entries:     PRS42_HUMAN (see all proteins) (see all similar genes):
    PRSS44    PROC    CTRL    PRSS45    PRSS47    TMPRSS2
    CTRB1    CTRB2    DESC1    F11    OVCH1    OVCH2
    PRSS8    TMPRSS11E    TPSB2    TPSAB1    DKFZp779M0222    PRSS27

    PRSS42 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS42 (see all 125)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443604061,2
    --46871427(+) TTTGAC/TAGATG 1 -- ds50010--------
    rs1142627671,2
    C,F--46871594(+) CCAGGC/ACCCAG 1 -- ds50011Minor allele frequency- A:0.06NA 120
    rs1486378691,2
    --46871641(+) GGCCCA/GTGGAT 1 -- ds50010--------
    rs1903013061,2
    --46871839(+) CACCAC/TTGCAA 1 -- ds50010--------
    rs2013203051,2
    C--46871917(+) GCCCCA/CGCTCA 2 G W mis10--------
    rs1998022571,2
    --46871994(+) GAAAGA/GGAAAG 1 -- int10--------
    rs1415893641,2
    --46872205(+) TGATGA/GCTTCT 1 -- int10--------
    rs1508846511,2
    --46872232(+) TGGCT-/GGG   
      GGGGGG
    GTTAA
    1 -- cds10--------
    rs738336381,2
    C,F--46872240(+) TAAACG/ATCTTG 1 -- int12Minor allele frequency- A:0.05WA 120
    rs746433551,2
    C,F--46872265(+) AGCCCA/CCTAAA 1 -- int12Minor allele frequency- C:0.13WA NA 238

    HapMap Linkage Disequilibrium report for PRSS42 (46871032 - 46875585 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PRSS42:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508915CNV Insertion20534489
    nsv876745CNV Loss21882294
    nsv428417CNV Loss18775914
    essv8614CNV CNV17122850
    dgv1455e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS42 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PRSS42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 2, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339906 HGNC: 30716 AceView: TESSP2 Ensembl:ENSG00000178055 euGenes: HUgn339906
    ECgene: PRSS42 H-InvDB: PRSS42

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS42 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS42 gene:
    Search GeneIP for patents involving PRSS42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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