Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRSS42 Gene

Aliases for PRSS42 Gene

  • Protease, Serine 42 2 3 5
  • Testis Serine Protease 2 2 3 4
  • TESSP2 3 4
  • Putative Testis Serine Protease 2 3
  • Protease, Serine, 42 3
  • EC 3.4.21.- 4

External Ids for PRSS42 Gene

Previous GeneCards Identifiers for PRSS42 Gene

  • GC03M046847

Summaries for PRSS42 Gene

GeneCards Summary for PRSS42 Gene

PRSS42 (Protease, Serine 42) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS42 Gene

Genomics for PRSS42 Gene

Regulatory Elements for PRSS42 Gene

Enhancers for PRSS42 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS42 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS42 Gene

46,829,542 bp from pter
46,834,095 bp from pter
4,554 bases
Minus strand

Genomic View for PRSS42 Gene

Genes around PRSS42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS42 Gene

Proteins for PRSS42 Gene

  • Protein details for PRSS42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 42
    Protein Accession:

    Protein attributes for PRSS42 Gene

    293 amino acids
    Molecular mass:
    32006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS42 Gene

Proteomics data for PRSS42 Gene at MOPED

Post-translational modifications for PRSS42 Gene

  • Glycosylation at Asn 141, Asn 177, and Asn 276
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS42 Gene

Domains & Families for PRSS42 Gene

Gene Families for PRSS42 Gene

Suggested Antigen Peptide Sequences for PRSS42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS42: view

Function for PRSS42 Gene

Enzyme Numbers (IUBMB) for PRSS42 Gene

genes like me logo Genes that share phenotypes with PRSS42: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS42

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS42 Gene

Localization for PRSS42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS42 Gene


Subcellular locations from

Jensen Localization Image for PRSS42 Gene COMPARTMENTS Subcellular localization image for PRSS42 gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRSS42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046658 anchored component of plasma membrane IEA --
genes like me logo Genes that share ontologies with PRSS42: view

Pathways & Interactions for PRSS42 Gene

SuperPathways for PRSS42 Gene

No Data Available

Interacting Proteins for PRSS42 Gene

Gene Ontology (GO) - Biological Process for PRSS42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007281 germ cell development IEA --
genes like me logo Genes that share ontologies with PRSS42: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS42 Gene

Drugs & Compounds for PRSS42 Gene

No Compound Related Data Available

Transcripts for PRSS42 Gene

mRNA/cDNA for PRSS42 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS42 Gene

Protease, serine, 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS42 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2: - - -

Relevant External Links for PRSS42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS42 Gene

mRNA expression in normal human tissues for PRSS42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS42 Gene

This gene is overexpressed in Heart - Left Ventricle (x24.7) and Muscle - Skeletal (x8.3).

SOURCE GeneReport for Unigene cluster for PRSS42 Gene Hs.585127

genes like me logo Genes that share expression patterns with PRSS42: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PRSS42 Gene

Orthologs for PRSS42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS42 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRSS42 35
  • 68.89 (n)
  • 58.43 (a)
PRSS42 36
  • 48 (a)
(Canis familiaris)
Mammalia PRSS42 35
  • 72.57 (n)
  • 59.67 (a)
PRSS42 36
  • 24 (a)
(Mus musculus)
Mammalia Prss42 35
  • 68.4 (n)
  • 56.75 (a)
Prss42 16
Prss42 36
  • 50 (a)
(Pan troglodytes)
Mammalia PRSS42 35
  • 98.98 (n)
  • 98.29 (a)
PRSS42 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Prss42 35
  • 67.69 (n)
  • 56.51 (a)
(Monodelphis domestica)
Mammalia PRSS42 36
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
-- 36
  • 31 (a)
Species with no ortholog for PRSS42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS42 Gene

Gene Tree for PRSS42 (if available)
Gene Tree for PRSS42 (if available)

Paralogs for PRSS42 Gene

genes like me logo Genes that share paralogs with PRSS42: view

Variants for PRSS42 Gene

Sequence variations from dbSNP and Humsavar for PRSS42 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7624422 -- 46,832,177(+) GAGGA(C/T)GTAAG intron-variant
rs9834044 -- 46,830,861(+) TCTCA(A/G)ACAGC intron-variant
rs7635241 -- 46,831,377(+) tgctg(A/T)tttcc intron-variant
rs7636089 -- 46,832,467(+) AACAG(A/G)AAATA intron-variant
rs7636864 -- 46,836,073(+) AACAA(C/G)CAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRSS42 Gene

Variant ID Type Subtype PubMed ID
dgv1455e1 CNV Complex 17122850
nsv428417 CNV Loss 18775914
nsv876745 CNV Loss 21882294
essv8614 CNV CNV 17122850
nsv508915 CNV Insertion 20534489

Variation tolerance for PRSS42 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRSS42 Gene

Disorders for PRSS42 Gene

Relevant External Links for PRSS42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRSS42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS42 Gene

Publications for PRSS42 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for PRSS42 Gene

Sources for PRSS42 Gene