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Aliases for PRSS42 Gene

Aliases for PRSS42 Gene

  • Protease, Serine, 42 2 3
  • Testis Serine Protease 2 2 3 4
  • TESSP2 3 4
  • Putative Testis Serine Protease 2 3
  • Serine Protease 42 3
  • EC 3.4.21.- 4

External Ids for PRSS42 Gene

Previous GeneCards Identifiers for PRSS42 Gene

  • GC03M046847

Summaries for PRSS42 Gene

GeneCards Summary for PRSS42 Gene

PRSS42 (Protease, Serine, 42) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS42 Gene

Genomics for PRSS42 Gene

Genomic Location for PRSS42 Gene

Start:
46,829,542 bp from pter
End:
46,834,095 bp from pter
Size:
4,554 bases
Orientation:
Minus strand

Genomic View for PRSS42 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS42 Gene

No data available for Regulatory Elements for PRSS42 Gene

Proteins for PRSS42 Gene

  • Protein details for PRSS42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5A4-PRS42_HUMAN
    Recommended name:
    Serine protease 42
    Protein Accession:
    Q7Z5A4
    Secondary Accessions:

    Protein attributes for PRSS42 Gene

    Size:
    293 amino acids
    Molecular mass:
    32006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS42 Gene

Proteomics data for PRSS42 Gene at MOPED

Post-translational modifications for PRSS42 Gene

  • Glycosylation at Asn141, Asn177, and Asn276
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS42 Gene

Domains for PRSS42 Gene

Gene Families for PRSS42 Gene

HGNC:
  • PRSS :Serine peptidases / Serine peptidases

Suggested Antigen Peptide Sequences for PRSS42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5A4

UniProtKB/Swiss-Prot:

PRS42_HUMAN :
  • Q7Z5A4
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS42: view

Function for PRSS42 Gene

Enzyme Numbers (IUBMB) for PRSS42 Gene

Gene Ontology (GO) - Molecular Function for PRSS42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PRSS42: view

Phenotypes for PRSS42 Gene

GenomeRNAi human phenotypes for PRSS42:
genes like me logo Genes that share phenotypes with PRSS42: view

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRSS42 Gene

Localization for PRSS42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS42 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS42 Gene COMPARTMENTS Subcellular localization image for PRSS42 gene
Compartment Confidence
extracellular 3
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRSS42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0046658 anchored component of plasma membrane IEA --
genes like me logo Genes that share ontologies with PRSS42: view

Pathways for PRSS42 Gene

SuperPathways for PRSS42 Gene

No Data Available

Interacting Proteins for PRSS42 Gene

Gene Ontology (GO) - Biological Process for PRSS42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007281 germ cell development IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with PRSS42: view

No data available for Pathways by source for PRSS42 Gene

Transcripts for PRSS42 Gene

mRNA/cDNA for PRSS42 Gene

(6) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS42 Gene

Protease, serine, 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS42 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2: - - -

Relevant External Links for PRSS42 Gene

GeneLoc Exon Structure for
PRSS42
ECgene alternative splicing isoforms for
PRSS42

Expression for PRSS42 Gene

mRNA expression in normal human tissues for PRSS42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS42 Gene

This gene is overexpressed in Heart - Left Ventricle (24.7) and Muscle - Skeletal (8.3).

SOURCE GeneReport for Unigene cluster for PRSS42 Gene Hs.585127

genes like me logo Genes that share expressions with PRSS42: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for PRSS42 Gene

Orthologs for PRSS42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS42 35
  • 98.98 (n)
  • 98.29 (a)
PRSS42 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS42 35
  • 68.89 (n)
  • 58.43 (a)
PRSS42 36
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS42 35
  • 72.57 (n)
  • 59.67 (a)
PRSS42 36
  • 24 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss42 35
  • 68.4 (n)
  • 56.75 (a)
Prss42 16
Prss42 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRSS42 36
  • 37 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss42 35
  • 67.69 (n)
  • 56.51 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for PRSS42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS42 Gene

ENSEMBL:
Gene Tree for PRSS42 (if available)
TreeFam:
Gene Tree for PRSS42 (if available)

Paralogs for PRSS42 Gene

genes like me logo Genes that share paralogs with PRSS42: view

Variants for PRSS42 Gene

Sequence variations from dbSNP and Humsavar for PRSS42 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6808587 -- 46,834,200(+) CCTAG(A/C/G)GGGTG upstream-variant-2KB
rs7624422 -- 46,832,177(+) GAGGA(C/T)GTAAG intron-variant
rs7635241 -- 46,831,377(+) tgctg(A/T)tttcc intron-variant
rs7636089 -- 46,832,467(+) AACAG(A/G)AAATA intron-variant
rs7636864 -- 46,836,073(+) AACAA(C/G)CAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRSS42 Gene

Variant ID Type Subtype PubMed ID
dgv1455e1 CNV Complex 17122850
nsv428417 CNV Loss 18775914
nsv876745 CNV Loss 21882294
essv8614 CNV CNV 17122850
nsv508915 CNV Insertion 20534489

Relevant External Links for PRSS42 Gene

HapMap Linkage Disequilibrium report
PRSS42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS42 Gene

Disorders for PRSS42 Gene

No disorders were found for PRSS42 Gene.

No data available for UniProtKB/Swiss-Prot for PRSS42 Gene

Publications for PRSS42 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for PRSS42 Gene

Sources for PRSS42 Gene

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