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Aliases for PRSS41 Gene

Aliases for PRSS41 Gene

  • Protease, Serine 41 2 3 5
  • Testis Serine Protease 1 2 4
  • TESSP1 3 4
  • Testis-Specific Serine Protease 1 3
  • Putative Serine Protease 41 3
  • Serine Protease 41 3
  • EC 3.4.21.- 4
  • TESSP-1 4

External Ids for PRSS41 Gene

Previous GeneCards Identifiers for PRSS41 Gene

  • GC16P002851
  • GC16P002852
  • GC16P002815
  • GC16P002853
  • GC16P002854
  • GC16P002855
  • GC16P002856
  • GC16P002857

Summaries for PRSS41 Gene

GeneCards Summary for PRSS41 Gene

PRSS41 (Protease, Serine 41) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS21.

Additional gene information for PRSS41 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS41 Gene

Genomics for PRSS41 Gene

Regulatory Elements for PRSS41 Gene

Enhancers for PRSS41 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H002750 1.4 ENCODE dbSUPER 12.4 -45.4 -45404 4.7 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF75A ZNF213-AS1 TSC2 ERVK13-1 ZNF263 E4F1 ENSG00000261938 SRRM2 NUBP2 ELOB
GH16H002867 1.4 ENCODE dbSUPER 11.4 +70.0 70001 2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 FOS LOC101929566 ENSG00000200059 ENSG00000261240 FLYWCH2 ZG16B FLYWCH1 SNORA3C PRSS41 PRSS33 ELOB
GH16H002793 1.5 FANTOM5 Ensembl ENCODE 7 -4.2 -4176 1.8 HDAC1 TBP PKNOX1 TBL1XR1 INSM2 KLF17 GATA2 ZNF366 SMARCC2 FOS PRSS41 TBC1D24 PDPK1 MEFV SRRM2 ATP6V0C GC16M002798 SNORA3C PRSS33
GH16H002756 0.6 ENCODE 12.4 -42.0 -41952 0.1 HDGF ZFHX2 ZNF473 POLR2A ZBTB33 EGR2 ELOB PRSS33 PRSS41 SNORA3C ZNF200 PRSS27 RNF151 PRSS22 ENSG00000260447 ENSG00000263235
GH16H002784 0.8 Ensembl 8 -12.3 -12283 4 TBP CTCF ESRRA ZNF664 HIC1 PATZ1 RCOR1 ZNF600 NR2F6 TRIM24 PRSS41 PRSS33 LOC107984895 LOC106660606 GC16M002778
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRSS41 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS41 Gene

Genomic Locations for PRSS41 Gene
chr16:2,798,476-2,805,302
(GRCh38/hg38)
Size:
6,827 bases
Orientation:
Plus strand
chr16:2,848,486-2,855,148
(GRCh37/hg19)

Genomic View for PRSS41 Gene

Genes around PRSS41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS41 Gene

Proteins for PRSS41 Gene

  • Protein details for PRSS41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTY9-PRS41_HUMAN
    Recommended name:
    Serine protease 41
    Protein Accession:
    Q7RTY9

    Protein attributes for PRSS41 Gene

    Size:
    318 amino acids
    Molecular mass:
    35078 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS41 Gene

Post-translational modifications for PRSS41 Gene

Other Protein References for PRSS41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS41 Gene

Domains & Families for PRSS41 Gene

Gene Families for PRSS41 Gene

Suggested Antigen Peptide Sequences for PRSS41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTY9

UniProtKB/Swiss-Prot:

PRS41_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS41: view

Function for PRSS41 Gene

Enzyme Numbers (IUBMB) for PRSS41 Gene

Phenotypes From GWAS Catalog for PRSS41 Gene

Gene Ontology (GO) - Molecular Function for PRSS41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0017080 sodium channel regulator activity IBA --
genes like me logo Genes that share ontologies with PRSS41: view

Phenotypes for PRSS41 Gene

genes like me logo Genes that share phenotypes with PRSS41: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS41 Gene

Localization for PRSS41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS41 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized in the plasma membrane of spermatogonia. Localized in intracellular compartment in spermatocytes, probably in the Golgi apparatus (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for PRSS41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0019897 extrinsic component of plasma membrane IBA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with PRSS41: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PRSS41 Gene

Pathways & Interactions for PRSS41 Gene

genes like me logo Genes that share pathways with PRSS41: view

Interacting Proteins for PRSS41 Gene

Gene Ontology (GO) - Biological Process for PRSS41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006508 proteolysis IEA --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with PRSS41: view

No data available for SIGNOR curated interactions for PRSS41 Gene

Drugs & Compounds for PRSS41 Gene

No Compound Related Data Available

Transcripts for PRSS41 Gene

mRNA/cDNA for PRSS41 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS41 Gene

Protease, serine, 41:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS41 Gene

No ASD Table

Relevant External Links for PRSS41 Gene

GeneLoc Exon Structure for
PRSS41
ECgene alternative splicing isoforms for
PRSS41

Expression for PRSS41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS41 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS41 Gene

This gene is overexpressed in Testis (x31.9) and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for PRSS41 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS41 Gene



Protein tissue co-expression partners for PRSS41 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS41 Gene:

PRSS41

SOURCE GeneReport for Unigene cluster for PRSS41 Gene:

Hs.647401
genes like me logo Genes that share expression patterns with PRSS41: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS41 Gene

Orthologs for PRSS41 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRSS41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS41 33
  • 98.42 (n)
cow
(Bos Taurus)
Mammalia LOC617302 33
  • 72.18 (n)
mouse
(Mus musculus)
Mammalia Prss41 33 16
  • 71.33 (n)
rat
(Rattus norvegicus)
Mammalia Prss41 33
  • 69.47 (n)
Species where no ortholog for PRSS41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS41 Gene

ENSEMBL:
Gene Tree for PRSS41 (if available)
TreeFam:
Gene Tree for PRSS41 (if available)

Paralogs for PRSS41 Gene

Variants for PRSS41 Gene

Sequence variations from dbSNP and Humsavar for PRSS41 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000172535 -- 2,802,911(+) TCTTA(C/T)AACAA intron-variant
rs1000198089 -- 2,802,753(+) GCAAT(C/T)GCAGG intron-variant
rs1000457577 -- 2,793,779(+) TGCTT(C/T)TGTTG intron-variant
rs1000462849 -- 2,798,015(+) GTGTG(C/T)CACCA intron-variant, upstream-variant-2KB
rs1000546415 -- 2,792,046(+) CGTCT(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS41 Gene

Variant ID Type Subtype PubMed ID
esv2760067 CNV gain+loss 17122850

Relevant External Links for PRSS41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PRSS41 Gene

Disorders for PRSS41 Gene

Relevant External Links for PRSS41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS41

No disorders were found for PRSS41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS41 Gene

Publications for PRSS41 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 4 60
  2. A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24. (PMID: 20797691) Corbett MA … Gecz J (American journal of human genetics 2010) 4 60
  3. T-SP1: a novel serine protease-like protein predominantly expressed in testis. (PMID: 18844450) Neth P … Jochum M (Biological chemistry 2008) 22 60
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 60

Products for PRSS41 Gene

Sources for PRSS41 Gene

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