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PRSS41 Gene

pseudogene   GIFtS: 34
GCID: GC16P002857

Protease, Serine, 41

  Search for PRSS41
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 411 2     Testis-Specific Serine Protease 12
Testis Serine Protease 11 3     EC 3.4.21.-3
TESSP12 3     TESSP-13
Putative Serine Protease 412     

External Ids:    HGNC: 307151   Entrez Gene: 3602262   Ensembl: ENSG000002151487   UniProtKB: Q7RTY93   

Export aliases for PRSS41 gene to outside databases

Previous GC identifers: GC16P002851 GC16P002852 GC16P002815 GC16P002853 GC16P002854 GC16P002855 GC16P002856


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRSS41 Gene:
PRSS41 (protease, serine, 41) is a pseudogene. GO annotations related to this gene include serine-type endopeptidase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PRSS41
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PRSS41

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PRSS41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS41 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002857:  view genomic region     (about GC identifiers)

Start:
2,848,486 bp from pter      End:
2,855,148 bp from pter
Size:
6,663 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRS41_HUMAN, Q7RTY9 (See protein sequence)
Recommended Name: Putative serine protease 41 precursor  
Size: 318 amino acids; 35078 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for PRSS41: NX_Q7RTY9

Explore proteomics data for PRSS41 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn211, Asn284

  • See PRSS41 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001128558.1  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q7RTY9

    ProtoNet protein and cluster: Q7RTY9

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRS41_HUMAN, Q7RTY9
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PRSS41           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 3.4.21.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--
         
    Find genes that share ontologies with PRSS41           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PRSS41:
     Increased gamma-H2AX phosphory 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRS41_HUMAN, Q7RTY9: Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized in the plasma membrane of
    spermatogonia. Localized in intracellular compartment in spermatocytes, probably in the Golgi apparatus (By
    similarity)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ISS--
    GO:0031225anchored component of membrane IEA--
    GO:0043229intracellular organelle ISS--

    Find genes that share ontologies with PRSS41           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS41
    Interactions:

        Search GeneGlobe Interaction Network for PRSS41

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS41 (PRS41)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRSS41 gene: 
    NM_001135086.1  

    Unigene Cluster for PRSS41:

    Protease, serine, 41
    Hs.647401  [show with all ESTs]
    Unigene Representative Sequence: NM_001135086
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399677(uc010uwi.2) ENST00000421271
    miRNA
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    1 DOTS entry:

    DT.70100984 

    6 AceView cDNA sequences:

    AW002891 BN000124 NM_183379 AW235371 AW243584 AW450670 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS41 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTGCTG
    PRSS41 Expression
    About this image

    PRSS41 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS41 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647401
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS41 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss411 , 5 protease, serine, 415
    protease, serine 411
    71.33(n)1
    64(a)1
      17 (12.09 cM)5
    710031  NM_027644.11  NP_081920.11 
     238367855 
    African clawed frog
    (Xenopus laevis)
    Amphibia AB018694.12   -- 75.37(n)    AB018694.1 


    ENSEMBL Gene Tree for PRSS41 (if available)
    TreeFam Gene Tree for PRSS41 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS41 gene
    Selected SIMAP similar genes for PRSS41 using alignment to 1 protein entry:     PRS41_HUMAN(see all similar genes):
    PRSS21    TMPRSS11D    TMPRSS11B    TMPRSS11F    PRSS22    PRSS36
    CORIN    DESC1    DKFZp779M0222    KLKB1    PRSS42    PRSS44
    PRSS48    TMPRSS11E    TMPRSS15    TMPRSS4    F11    PRSS27

    Find genes that share paralogs with PRSS41           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS41 (see all 220)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734811081,2
    C,F--2846491(+) GTACCG/ATAGCA 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs1442807421,2
    --2846492(+) TACCGC/TAGCAC 1 -- us2k10--------
    rs1174514231,2
    C,F--2846515(+) GTCAGC/GATGCG 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1177762831,2
    C,F--2846552(+) TTTTAC/TGAATA 1 -- us2k11Minor allele frequency- T:0.04EA 120
    rs1464781991,2
    --2846558(+) GAATAA/CAGTTT 1 -- us2k10--------
    rs1895836651,2
    --2846578(+) AACAAC/GGAGGA 1 -- us2k10--------
    rs1928517561,2
    C--2846683(+) TGAGCA/GAAGGA 1 -- us2k10--------
    rs2017155991,2
    C--2846747(+) ATTGA-/AT/ATA
            
    TGTTT
    2 -- us2k1 cds10--------
    rs1495664091,2
    C--2846749(+) TTGAT-/ATAATGTT 1 -- cds10--------
    rs1411286301,2
    --2846787(+) TAATTA/CATGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRSS41 (2848486 - 2855148 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PRSS41:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905173CNV Loss21882294
    nsv905165CNV Loss21882294
    nsv905152CNV Loss21882294
    nsv905170CNV Loss21882294
    dgv2573n71CNV Loss21882294
    nsv905169CNV Loss21882294
    nsv905162CNV Gain21882294
    dgv793e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS41 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PRSS41)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 2, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    2. A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24. (PubMed id 20797691)2 Corbett M.A.... Gecz J. (Am. J. Hum. Genet. 2010)
    3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    4. T-SP1: a novel serine protease-like protein predominantly expressed in testis. (PubMed id 18844450)9 Neth P....Jochum M. (Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 360226 HGNC: 30715 AceView: TESSP1 Ensembl:ENSG00000215148 euGenes: HUgn360226
    ECgene: PRSS41 H-InvDB: PRSS41

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS41 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS41 gene:
    Search GeneIP for patents involving PRSS41

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Search for Antibodies for PRSS41 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PRSS41
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     Browse ProSpec Recombinant Proteins
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     Browse ESI BIO Cell Lines and PureStem Progenitors for PRSS41
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for PRSS41
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     Search ThermoFisher Antibodies for PRSS41
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS41
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRSS41
     LSBio Antibodies in human, mouse, rat for PRSS41
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     Search Addgene for plasmids for PRSS41
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      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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