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Aliases for PRSS37 Gene

Aliases for PRSS37 Gene

  • Protease, Serine 37 2 3 5
  • Probable Inactive Trypsin-X2 3 4
  • TRYX2 3 4
  • Peptidase S1 Domain-Containing Protein LOC136242 3
  • Protease, Serine, 37 3

External Ids for PRSS37 Gene

Previous GeneCards Identifiers for PRSS37 Gene

  • GC07M141183
  • GC07M141536
  • GC07M135832

Summaries for PRSS37 Gene

GeneCards Summary for PRSS37 Gene

PRSS37 (Protease, Serine 37) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS58.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS37 Gene

Genomics for PRSS37 Gene

Regulatory Elements for PRSS37 Gene

Enhancers for PRSS37 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS37 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS37 Gene

141,836,278 bp from pter
141,842,499 bp from pter
6,222 bases
Minus strand

Genomic View for PRSS37 Gene

Genes around PRSS37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS37 Gene

Proteins for PRSS37 Gene

  • Protein details for PRSS37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable inactive serine protease 37
    Protein Accession:
    Secondary Accessions:
    • B2RPB5

    Protein attributes for PRSS37 Gene

    235 amino acids
    Molecular mass:
    26445 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS37 Gene

Proteomics data for PRSS37 Gene at MOPED

Post-translational modifications for PRSS37 Gene

No Post-translational modifications

Other Protein References for PRSS37 Gene

No data available for DME Specific Peptides for PRSS37 Gene

Domains & Families for PRSS37 Gene

Gene Families for PRSS37 Gene

Protein Domains for PRSS37 Gene

Suggested Antigen Peptide Sequences for PRSS37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS37: view

Function for PRSS37 Gene

genes like me logo Genes that share phenotypes with PRSS37: view

Animal Models for PRSS37 Gene

MGI Knock Outs for PRSS37:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS37 Gene

Localization for PRSS37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS37 Gene


Subcellular locations from

Jensen Localization Image for PRSS37 Gene COMPARTMENTS Subcellular localization image for PRSS37 gene
Compartment Confidence
nucleus 5
extracellular 4
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PRSS37 Gene

Pathways & Interactions for PRSS37 Gene

SuperPathways for PRSS37 Gene

No Data Available

Interacting Proteins for PRSS37 Gene

Gene Ontology (GO) - Biological Process for PRSS37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IEA --
genes like me logo Genes that share ontologies with PRSS37: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS37 Gene

Drugs & Compounds for PRSS37 Gene

No Compound Related Data Available

Transcripts for PRSS37 Gene

Unigene Clusters for PRSS37 Gene

Protease, serine, 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS37 Gene

No ASD Table

Relevant External Links for PRSS37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS37 Gene

mRNA expression in normal human tissues for PRSS37 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS37 Gene

This gene is overexpressed in Testis (x42.8).

Protein differential expression in normal tissues from HIPED for PRSS37 Gene

This gene is overexpressed in Testis (61.2) and Ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS37 Gene

SOURCE GeneReport for Unigene cluster for PRSS37 Gene Hs.98947

genes like me logo Genes that share expression patterns with PRSS37: view

Protein tissue co-expression partners for PRSS37 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRSS37 Gene

Orthologs for PRSS37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS37 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRSS37 35
  • 84.33 (n)
  • 83.33 (a)
PRSS37 36
  • 83 (a)
(Canis familiaris)
Mammalia PRSS37 35
  • 85.84 (n)
  • 85.84 (a)
PRSS37 36
  • 86 (a)
(Mus musculus)
Mammalia Prss37 35
  • 83.76 (n)
  • 82.91 (a)
Prss37 16
Prss37 36
  • 82 (a)
(Pan troglodytes)
Mammalia PRSS37 35
  • 99 (n)
  • 98.72 (a)
PRSS37 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Prss37 35
  • 83.48 (n)
  • 82.05 (a)
(Monodelphis domestica)
Mammalia PRSS37 36
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
Species with no ortholog for PRSS37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS37 Gene

Gene Tree for PRSS37 (if available)
Gene Tree for PRSS37 (if available)

Paralogs for PRSS37 Gene

Paralogs for PRSS37 Gene

(9) SIMAP similar genes for PRSS37 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PRSS37: view

Variants for PRSS37 Gene

Sequence variations from dbSNP and Humsavar for PRSS37 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs12669721 - 141,837,935(+) GAGGG(G/T)AAGGG reference, missense
rs6951500 -- 141,836,852(+) TGCCT(A/G)TTTTC intron-variant
rs6952829 -- 141,840,489(+) aagtg(A/C)tttac intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs12668495 -- 141,842,171(+) ccccc(A/C)ccagg upstream-variant-2KB, utr-variant-5-prime
rs12670179 -- 141,843,911(+) aatgc(C/T)tatgt upstream-variant-2KB

Variation tolerance for PRSS37 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS37 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRSS37 Gene

Disorders for PRSS37 Gene

Relevant External Links for PRSS37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRSS37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS37 Gene

Publications for PRSS37 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 67
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PRSS37 Gene

Sources for PRSS37 Gene