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PRSS37 Gene

protein-coding   GIFtS: 37
GCID: GC07M141536

Protease, Serine, 37

  Search for PRSS37
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 371 2
Probable Inactive Trypsin-X22 3
TRYX22 3
Peptidase S1 Domain-Containing Protein LOC1362422
Probable Inactive Serine Protease 372

External Ids:    HGNC: 292111   Entrez Gene: 1362422   Ensembl: ENSG000001650767   UniProtKB: A4D1T93   

Export aliases for PRSS37 gene to outside databases

Previous GC identifers: GC07M141183 GC07M135832


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRSS37 Gene:
PRSS37 (protease, serine, 37) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK10.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PRSS37
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PRSS37

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

PRSS37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS37 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M141536:  view genomic region     (about GC identifiers)

Start:
141,536,078 bp from pter      End:
141,541,287 bp from pter
Size:
5,210 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 140,873,792-140,878,935     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRS37_HUMAN, A4D1T9 (See protein sequence)
Recommended Name: Probable inactive serine protease 37 precursor  
Size: 235 amino acids; 26445 Da
Caution: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 192 which is
replaced by an Ala, suggesting that it has no protease activity. Lacks also metal binding sites Glu in position
67 which is replaced by Asn and Asn in position 69 which is replaced by Lys
Secondary accessions: B2RPB5

Explore the universe of human proteins at neXtProt for PRSS37: NX_A4D1T9

Explore proteomics data for PRSS37 at MOPED


See PRSS37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001008271.2  NP_001165422.1  

ENSEMBL proteins: 
 ENSP00000297767   ENSP00000398810   ENSP00000414461   ENSP00000395287  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PRSS: Serine peptidases / Serine peptidases

3 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry A4D1T9

ProtoNet protein and cluster: A4D1T9

UniProtKB/Swiss-Prot: PRS37_HUMAN, A4D1T9
Similarity: Belongs to the peptidase S1 family
Similarity: Contains 1 peptidase S1 domain


Find genes that share domains with PRSS37           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
     
Find genes that share ontologies with PRSS37           About GenesLikeMe


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Prss37):
 reproductive system 

Find genes that share phenotypes with PRSS37           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Prss37tm1Zgwg for PRSS37

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
PRS37_HUMAN, A4D1T9: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytosol1
lysosome1
mitochondrion1
nucleus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with PRSS37           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS37
Interactions:

    Search GeneGlobe Interaction Network for PRSS37

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis ----

Find genes that share ontologies with PRSS37           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PRSS37 (PRS37)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PRSS37 gene (2 alternative transcripts): 
NM_001008270.2  NM_001171951.1  

Unigene Cluster for PRSS37:

Protease, serine, 37
Hs.98947  [show with all ESTs]
Unigene Representative Sequence: NM_001008270
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000350549(uc003vws.2 uc011krl.2 uc011krk.2) ENST00000419085(uc003vwt.2)
ENST00000438520 ENST00000452758
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Additional mRNA sequence: 

AK172866.1 BC137353.1 BC137354.1 BC144604.1 BC144605.1 

3 DOTS entries:

DT.102820963  DT.75189794  DT.92418339 

22 AceView cDNA sequences:

BF515133 AK172866 AK097648 AI024881 AA460296 AA628371 AW102593 AI024859 
BX097528 AI217334 AA461584 AA725003 AA437263 BG192709 BG181739 BG217724 
BG219738 AI805861 AA954545 AA971595 BG194745 BG197781 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PRSS37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACTATACAA
PRSS37 Expression
About this image

PRSS37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PRSS37 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.98947
    Custom PCR Arrays for PRSS37
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS37

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for PRSS37 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Prss371 , 5 protease, serine, 375
protease, serine 371
83.76(n)1
82.91(a)1
  6 (18.82 cM)5
676901  NM_026317.21  NP_080593.11 
 405148245 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
27(a)
1 → many
GL343276.1(1631121-1647585)


ENSEMBL Gene Tree for PRSS37 (if available)
TreeFam Gene Tree for PRSS37 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PRSS37 gene
KLK102  ENSG000002697412  KLK12  KLK42  KLK112  KLK72  KLK142  KLK92  
KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
PRSS32  KLK82  KLK32  
9 SIMAP similar genes for PRSS37 using alignment to 3 protein entries:     PRS37_HUMAN (see all proteins):
LOC136242    LOC730441    PRSS3    PRSS1    PRSS2    TRY8
PRSS58    KLK6    KLK14

Find genes that share paralogs with PRSS37           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PRSS37 (see all 210)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1490119661,2
Cuntested1141537835(+) CGGACA/C/GATCTG 4 I syn11EU 1323
rs624784931,2
C,F--141535672(+) TCCTCA/GGAGAG 2 -- ds50015Minor allele frequency- G:0.16NA CSA WA EA 362
rs737382821,2
C,F--141535706(+) AGCCAC/GAAGTG 2 -- ds50013Minor allele frequency- G:0.21WA CSA 121
rs783973581,2
C,F--141535876(+) TATGGG/ACAATG 2 -- ds50014Minor allele frequency- A:0.08CSA WA 124
rs624784941,2
C,F--141535878(+) TGGGCA/GATGTT 2 -- ds50015Minor allele frequency- G:0.16NA CSA WA EA 362
rs1878863741,2
--141536038(+) CACACC/TGTTGT 2 -- ds50010--------
rs1114902441,2
C,F--141536112(+) TTGGAG/TATTTT 2 -- ut311Minor allele frequency- T:0.50CSA 2
rs69678731,2
C,F,A,H--141536143(+) TATCTG/ACTTGT 2 -- ut316Minor allele frequency- A:0.05NS EA CSA WA 540
rs2011206041,2
--141536148(+) GCTTGG/TATAGT 2 -- ut310--------
rs2001702921,2
C--141536186(+) GGAGAA/GGTAGG 2 -- ut310--------

HapMap Linkage Disequilibrium report for PRSS37 (141536078 - 141541287 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for PRSS37: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing PRSS37
DNA2.0 Custom Variant and Variant Library Synthesis for PRSS37

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PRSS37 gene integrated from 10 sources:
(articles sorted by number of sources associating them with PRSS37)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 136242 HGNC: 29211 AceView: LOC136242 Ensembl:ENSG00000165076 euGenes: HUgn136242
ECgene: PRSS37 H-InvDB: PRSS37

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PRSS37 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PRSS37 gene:
Search GeneIP for patents involving PRSS37

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for PRSS37
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS37
 Browse SwitchGear 3'UTR luciferase reporter plasmids for PRSS37
 Browse SwitchGear Promoter luciferase reporter plasmids for PRSS37
 ThermoFisher Antibodies for PRSS37
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS37
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS37
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRSS37
 LSBio Antibodies in human, mouse, rat for PRSS37
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for PRSS37
  Search eBioscience for proteins for PRSS37
  Search eBioscience for elisas for PRSS37
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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