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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRSS37 Gene

protein-coding   GIFtS: 36
GCID: GC07M141536

Protease, Serine, 37

  Search for PRSS37
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protease, Serine, 371 2
Probable Inactive Trypsin-X22 3
TRYX22 3
Peptidase S1 Domain-Containing Protein LOC1362422
Probable Inactive Serine Protease 372

External Ids:    HGNC: 292111   Entrez Gene: 1362422   Ensembl: ENSG000001650767   UniProtKB: A4D1T93   

Export aliases for PRSS37 gene to outside databases

Previous GC identifers: GC07M141183 GC07M135832


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PRSS37 Gene: 
PRSS37 (protease, serine, 37) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK10.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PRSS37
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PRSS37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

PRSS37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS37 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M141536:  view genomic region     (about GC identifiers)

Start:
141,536,078 bp from pter      End:
141,541,287 bp from pter
Size:
5,210 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 140,873,792-140,878,935     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRS37_HUMAN, A4D1T9 (See protein sequence)
Recommended Name: Probable inactive serine protease 37 precursor  
Size: 235 amino acids; 26445 Da
Subcellular location: Secreted (Potential)
Caution: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 192 which is
replaced by an Ala, suggesting that it has no protease activity. Lacks also metal binding sites Glu in position
67 which is replaced by Asn and Asn in position 69 which is replaced by Lys
Secondary accessions: B2RPB5

Explore the universe of human proteins at neXtProt for PRSS37: NX_A4D1T9

Explore proteomics data for PRSS37 at MOPED 

PRSS37 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

PRSS37 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001008271.2  NP_001165422.1  

ENSEMBL proteins: 
 ENSP00000297767   ENSP00000398810   ENSP00000414461   ENSP00000395287  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

PRSS37 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
PRSS: Serine peptidases / Serine peptidases

3 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry A4D1T9

ProtoNet protein and cluster: A4D1T9

UniProtKB/Swiss-Prot: PRS37_HUMAN, A4D1T9
Similarity: Belongs to the peptidase S1 family
Similarity: Contains 1 peptidase S1 domain


PRSS37 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
     
PRSS37 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRSS37

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--

PRSS37 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for PRSS37 (PRS37)

Search CenterWatch for drugs/clinical trials and news about PRSS37 / PRS37

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRSS37 gene (2 alternative transcripts): 
NM_001008270.2  NM_001171951.1  

Unigene Cluster for PRSS37:

Protease, serine, 37
Hs.98947  [show with all ESTs]
Unigene Representative Sequence: NM_001008270
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000350549(uc003vws.2 uc011krl.2 uc011krk.2) ENST00000419085(uc003vwt.2)
ENST00000438520 ENST00000452758
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Additional mRNA sequence: 

AK172866.1 BC137353.1 BC137354.1 BC144604.1 BC144605.1 

3 DOTS entries:

DT.102820963  DT.75189794  DT.92418339 

22 AceView cDNA sequences:

AK172866 BF515133 AI217334 AW102593 BX097528 AI024859 AI024881 AA628371 
AA461584 AK097648 AA460296 BG192709 AA725003 AA437263 BG181739 BG217724 
BG219738 AI805861 AA954545 AA971595 BG194745 BG197781 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRSS37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACTATACAA
PRSS37 Expression
About this image


See PRSS37 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRSS37

SOURCE GeneReport for Unigene cluster: Hs.98947
    SABiosciences Custom PCR Arrays for PRSS37
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS37

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for PRSS37 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Prss371 , 5 protease, serine, 371, 5 83.97(n)1
82.98(a)1
  6 (18.82 cM)5
676901  NM_026317.21  NP_080593.11 
 405148245 


ENSEMBL Gene Tree for PRSS37 (if available)
TreeFam Gene Tree for PRSS37 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for PRSS37 gene
KLK102  ENSG000002697412  KLK12  KLK42  KLK112  KLK72  KLK142  KLK92  
KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  PRSS582  
PRSS32  KLK82  KLK32  
10 SIMAP similar genes for PRSS37 using alignment to 3 protein entries:     PRS37_HUMAN (see all proteins):
LOC136242    LOC730441    PRSS3    PRSS1    TRY6    PRSS2
TRY8    PRSS58    KLK6    KLK14

PRSS37 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/210 SNPs in PRSS37 are shown (see all 210)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1490119661,2
Cuntested1141537835(+) CGGACA/C/GATCTG 4 I syn11EU 1323
rs624784931,2
C,F--141535672(+) TCCTCA/GGAGAG 2 -- ds50015Minor allele frequency- G:0.16NA CSA WA EA 362
rs737382821,2
C,F--141535706(+) AGCCAC/GAAGTG 2 -- ds50013Minor allele frequency- G:0.21WA CSA 121
rs783973581,2
C,F--141535876(+) TATGGG/ACAATG 2 -- ds50014Minor allele frequency- A:0.08CSA WA 124
rs624784941,2
C,F--141535878(+) TGGGCA/GATGTT 2 -- ds50015Minor allele frequency- G:0.16NA CSA WA EA 362
rs1878863741,2
--141536038(+) CACACC/TGTTGT 2 -- ds50010--------
rs1114902441,2
C,F--141536112(+) TTGGAG/TATTTT 2 -- ut311Minor allele frequency- T:0.50CSA 2
rs69678731,2
C,F,A,H--141536143(+) TATCTG/ACTTGT 2 -- ut316Minor allele frequency- A:0.05NS EA CSA WA 540
rs2011206041,2
--141536148(+) GCTTGG/TATAGT 2 -- ut310--------
rs2001702921,2
C--141536186(+) GGAGAA/GGTAGG 2 -- ut310--------

HapMap Linkage Disequilibrium report for PRSS37 (141536078 - 141541287 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for PRSS37: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing PRSS37
DNA2.0 Custom Variant and Variant Library Synthesis for PRSS37

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for PRSS37 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PRSS37)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 136242 HGNC: 29211 AceView: LOC136242 Ensembl:ENSG00000165076 euGenes: HUgn136242
ECgene: PRSS37 H-InvDB: PRSS37

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for PRSS37 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for PRSS37 gene:
Search GeneIP for patents involving PRSS37

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Browse Proteins at Cloud-Clone Corp.
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 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for PRSS37
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS37
 Browse SwitchGear 3'UTR luciferase reporter plasmids for PRSS37
 Browse SwitchGear Promoter luciferase reporter plasmids for PRSS37
 ThermoFisher Antibodies for PRSS37
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS37
 inGenious Targeting Laboratory - Custom generated mouse model solutions for PRSS37
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRSS37
Customized:
 lentivirus for stable overexpression of PRSS37
 lentivirus expression plasmids for stable overexpression of PRSS37
 adenovirus for overexpression of PRSS37
 Search LSBio for Antibodies for PRSS37
Customized transgenic rodents for:
 Humanization
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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