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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRSS37 Gene

protein-coding GIFtS: 37
GCID: GC07M141536

protease, serine, 37

Search for PRSS37
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protease, Serine, 37¹ ²
Probable Inactive Trypsin-X2² ³
TRYX2² ³
Peptidase S1 Domain-Containing Protein LOC136242²
Probable Inactive Serine Protease 37²

External Ids:	HGNC: 29211¹	Entrez Gene: 136242²	Ensembl: ENSG00000165076⁷	UniProtKB: A4D1T9³

Export aliases for PRSS37 gene to outside databases

Previous GC identifers: GC07M141183 GC07M135832

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for PRSS37
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for PRSS37

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS37

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34

PRSS37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS37 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M141536: view genomic region (about GC identifiers)

Start:	141,536,078 bp from pter	End:	141,541,287 bp from pter
Size:	5,210 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 140,873,792-140,878,935

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRS37_HUMAN, A4D1T9 (See protein sequence)

Recommended Name: Probable inactive serine protease 37 precursor

Size: 235 amino acids; 26445 Da

Subcellular location: Secreted (Potential)

Caution: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 192 which is

replaced by an Ala, suggesting that it has no protease activity. Lacks also metal binding sites Glu in position 67

which is replaced by Asn and Asn in position 69 which is replaced by Lys

Secondary accessions: B2RPB5

Explore the universe of human proteins at neXtProt for PRSS37: NX_A4D1T9

PRSS37 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001008271.2 NP_001165422.1

ENSEMBL proteins:

ENSP00000297767 ENSP00000398810 ENSP00000414461 ENSP00000395287

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

PRSS37 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRSS37 for domains About GeneDecksing

3 InterPro domains/families:

IPR001314 Peptidase_S1A

IPR001254 Peptidase_S1

IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry A4D1T9

ProtoNet protein and cluster: A4D1T9

UniProtKB/Swiss-Prot: PRS37_HUMAN, A4D1T9

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 1 peptidase S1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004252	serine-type endopeptidase activity	IEA	--

PRSS37 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PRSS37

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

PRSS37 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for PRSS37
Search CenterWatch for drugs/clinical trials and news about PRSS37 / PRS37

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for PRSS37 gene (2 alternative transcripts):

NM_001008270.2 NM_001171951.1

Unigene Cluster for PRSS37:

Protease, serine, 37

Hs.98947 [show with all ESTs]

Unigene Representative Sequence: NM_001008270

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000350549(uc003vws.2 uc011krl.2 uc011krk.2) ENST00000419085(uc003vwt.2)

ENST00000438520 ENST00000452758

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Additional cDNA sequence:

AK172866.1 BC137353.1 BC137354.1 BC144604.1 BC144605.1

3 DOTS entries:

DT.102820963 DT.75189794 DT.92418339

22 AceView cDNA sequences:

AK172866 BF515133 AA628371 BX097528 AI217334 AK097648 AI024881 AW102593

AI024859 AA460296 AA461584 BG217724 BG192709 BG219738 BG181739 AI805861

AA725003 AA437263 AA954545 AA971595 BG194745 BG197781

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRSS37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTATACAA

About this image

PRSS37 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRSS37 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRSS37

SOURCE GeneReport for Unigene cluster: Hs.98947

SABiosciences Custom PCR Arrays for PRSS37

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for PRSS37 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Prss37^{1 , 5}	protease, serine, 37^{1, 5}	83.97(n)¹ 82.98(a)¹		6 (18.82 cM)⁵ 67690¹ NM_026317.2¹ NP_080593.1¹ 40514824⁵

ENSEMBL Gene Tree for PRSS37 (if available)
TreeFam Gene Tree for PRSS37 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRSS37 gene

KLK10² KLK1² KLK4² KLK11² KLK7² KLK14² KLK9² KLK12²

KLK13² KLK6² KLK2² KLK15² KLK5² PRSS1² PRSS58² PRSS3²

KLK3² KLK8²

10 SIMAP similar genes for PRSS37 using alignment to 3 protein entries: PRS37_HUMAN (see all proteins):

LOC136242 LOC730441 PRSS3 PRSS1 TRY6 PRSS2

TRY8 PRSS58 KLK6 KLK14

PRSS37 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62478493^1,2	C,F,	--	141535672(+)	`TCCTCA/GGAGAG`	2	--	ds500¹		5		NA CSA WA EA	362
rs73738282^1,2	C,	--	141535706(+)	`AGCCAC/GAAGTG`	2	--	ds500¹		3		WA CSA	121
rs78397358^1,2	F,	--	141535876(+)	`TATGGG/ACAATG`	2	--	ds500¹		4		CSA WA	124
rs62478494^1,2	C,F,	--	141535878(+)	`TGGGCA/GATGTT`	2	--	ds500¹		5		NA CSA WA EA	362
rs187886374^1,2		--	141536038(+)	`CACACC/TGTTGT`	2	--	ds500¹		0	--	--	--	--
rs111490244^1,2		--	141536112(+)	`TTGGAG/TATTTT`	2	--	ut3¹		1		CSA	2
rs6967873^1,2	C,F,A,H,	--	141536143(+)	`TATCTG/ACTTGT`	2	--	ut3¹		6		NS EA CSA WA	540
rs201120604^1,2		--	141536148(+)	`GCTTGG/TATAGT`	2	--	ut3¹		0	--	--	--	--
rs200170292^1,2	C,	--	141536186(+)	`GGAGAA/GGTAGG`	2	--	ut3¹		0	--	--	--	--
rs201874957^1,2	C,	--	141536226(+)	`TCCAGC/G/TATACA`	6	Y S C	mis¹		1		EU	1323

HapMap Linkage Disequilibrium report for PRSS37 (141536078 - 141541287 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRSS37: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PRSS37 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PRSS37)

Utopia: connect your pdf to the dynamic
world of online information

Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 136242	HGNC: 29211	AceView: LOC136242	Ensembl:ENSG00000165076	euGenes: HUgn136242
ECgene: PRSS37	H-InvDB: PRSS37

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRSS37	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PRSS37 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PRSS37 gene:
Search GeneIP for patents involving PRSS37

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS37

	Browse SwitchGear 3'UTR luciferase reporter plasmids for PRSS37
	Browse SwitchGear Promoter luciferase reporter plasmids for PRSS37

ThermoFisher Antibodies for PRSS37

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS37

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PRSS37 gene at Home site.

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PRSS37 Gene

protease, serine, 37

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PRSS37 Gene

protease, serine, 37

Aliasesfor PRSS37 gene

Summariesfor PRSS37 gene

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Protein Domains /Familiesfor PRSS37 gene

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Other Databases showing PRSS37 gene

Specialized Databases showing PRSS37 gene

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for PRSS37 gene

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for PRSS37 gene

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for PRSS37 gene

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for PRSS37 gene

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for PRSS37 gene

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for PRSS37 gene

Pathways & Interactions
for PRSS37 gene

Drugs & Compounds
for PRSS37 gene

Transcripts
for PRSS37 gene

Expression
for PRSS37 gene

Orthologs
for PRSS37 gene

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for PRSS37 gene

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for PRSS37 gene

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for PRSS37 gene

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for PRSS37 gene

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for PRSS37 gene

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for PRSS37 gene