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Aliases for PRSS35 Gene

Aliases for PRSS35 Gene

  • Protease, Serine 35 2 3 5
  • C6orf158 3 4
  • Chromosome 6 Open Reading Frame 158 2
  • Protease, Serine, 35 3
  • EC 63
  • DJ223E3.1 3
  • EC 3.4.21 63

External Ids for PRSS35 Gene

Previous HGNC Symbols for PRSS35 Gene

  • C6orf158

Previous GeneCards Identifiers for PRSS35 Gene

  • GC06P084278

Summaries for PRSS35 Gene

GeneCards Summary for PRSS35 Gene

PRSS35 (Protease, Serine 35) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS23.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS35 Gene

Genomics for PRSS35 Gene

Regulatory Elements for PRSS35 Gene

Enhancers for PRSS35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS35 on UCSC Golden Path with GeneCards custom track

Promoters for PRSS35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRSS35 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS35 Gene

83,512,475 bp from pter
83,525,704 bp from pter
13,230 bases
Plus strand

Genomic View for PRSS35 Gene

Genes around PRSS35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS35 Gene

Proteins for PRSS35 Gene

  • Protein details for PRSS35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive serine protease 35
    Protein Accession:
    Secondary Accessions:
    • A8K7B3
    • Q9BQP6

    Protein attributes for PRSS35 Gene

    413 amino acids
    Molecular mass:
    47098 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS35 Gene

Proteomics data for PRSS35 Gene at MOPED

Selected DME Specific Peptides for PRSS35 Gene

Post-translational modifications for PRSS35 Gene

  • Glycosylation at Asn 90
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS35 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PRSS35 Gene

Gene Families for PRSS35 Gene

Suggested Antigen Peptide Sequences for PRSS35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS35: view

Function for PRSS35 Gene

Enzyme Numbers (IUBMB) for PRSS35 Gene

genes like me logo Genes that share phenotypes with PRSS35: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS35

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS35 Gene

Localization for PRSS35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS35 Gene


Subcellular locations from

Jensen Localization Image for PRSS35 Gene COMPARTMENTS Subcellular localization image for PRSS35 gene
Compartment Confidence
extracellular 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PRSS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with PRSS35: view

Pathways & Interactions for PRSS35 Gene

SuperPathways for PRSS35 Gene

No Data Available

Interacting Proteins for PRSS35 Gene

Gene Ontology (GO) - Biological Process for PRSS35 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRSS35 Gene

Drugs & Compounds for PRSS35 Gene

No Compound Related Data Available

Transcripts for PRSS35 Gene

mRNA/cDNA for PRSS35 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS35 Gene

Protease, serine, 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS35 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for PRSS35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS35 Gene

mRNA expression in normal human tissues for PRSS35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS35 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.7), Brain - Nucleus accumbens (basal ganglia) (x5.1), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for PRSS35 Gene

This gene is overexpressed in Vitreous humor (39.2) and Retina (29.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS35 Gene

SOURCE GeneReport for Unigene cluster for PRSS35 Gene Hs.98381

genes like me logo Genes that share expression patterns with PRSS35: view

Protein tissue co-expression partners for PRSS35 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PRSS35 Gene

Orthologs for PRSS35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRSS35 35
  • 82.85 (n)
  • 83.25 (a)
PRSS35 36
  • 83 (a)
(Canis familiaris)
Mammalia PRSS35 35
  • 88.92 (n)
  • 89.81 (a)
PRSS35 36
  • 90 (a)
(Mus musculus)
Mammalia Prss35 35
  • 78.32 (n)
  • 78 (a)
Prss35 16
Prss35 36
  • 77 (a)
(Pan troglodytes)
Mammalia PRSS35 35
  • 99.27 (n)
  • 98.79 (a)
PRSS35 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Prss35 35
  • 78.65 (n)
  • 80.05 (a)
(Ornithorhynchus anatinus)
Mammalia PRSS35 36
  • 72 (a)
(Gallus gallus)
Aves PRSS35 35
  • 70.39 (n)
  • 70.63 (a)
PRSS35 36
  • 70 (a)
(Anolis carolinensis)
Reptilia PRSS35 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prss35 35
  • 62.47 (n)
  • 60.53 (a)
(Danio rerio)
Actinopterygii prss35 35
  • 60.23 (n)
  • 56.66 (a)
prss35 36
  • 50 (a)
PRSS35 (2 of 2) 36
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for PRSS35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS35 Gene

Gene Tree for PRSS35 (if available)
Gene Tree for PRSS35 (if available)

Paralogs for PRSS35 Gene

Paralogs for PRSS35 Gene

(1) SIMAP similar genes for PRSS35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRSS35: view

Variants for PRSS35 Gene

Sequence variations from dbSNP and Humsavar for PRSS35 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs504593 - 83,524,112(-) TCTCC(C/T)GCAGA reference, missense
rs1171108 -- 83,512,554(+) AGCTC(C/T)GGGTG utr-variant-5-prime
rs1171110 -- 83,515,971(+) cagca(C/T)gcctg intron-variant
rs1171111 -- 83,516,066(+) cacct(A/C/T)ggcct intron-variant
rs1171112 -- 83,516,849(+) cccct(A/G)tgatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS35 Gene

Variant ID Type Subtype PubMed ID
nsv518229 CNV Loss 19592680
esv996120 CNV Deletion 20482838

Variation tolerance for PRSS35 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRSS35 Gene

Disorders for PRSS35 Gene

Relevant External Links for PRSS35

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRSS35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS35 Gene

Publications for PRSS35 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PMID: 16870946) Miyakoshi K. … Hennebold J.D. (Biol. Reprod. 2006) 3 23
  3. Genome-wide association of mood-incongruent psychotic bipolar disorder. (PMID: 23092984) Goes F.S. … Potash J.B. (Transl Psychiatry 2012) 3
  4. Novel cleft susceptibility genes in chromosome 6q. (PMID: 20511563) Letra A. … Vieira A.R. (J. Dent. Res. 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for PRSS35 Gene

Sources for PRSS35 Gene