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PRSS35 Gene

protein-coding   GIFtS: 50
GCID: GC06P084278

Protease, Serine, 35

(Previous name: chromosome 6 open reading frame 158)
(Previous symbol: C6orf158)
  Search for PRSS35
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 351 2     Inactive Serine Protease 352
C6orf1581 2 3     EC 3.4.218
Chromosome 6 Open Reading Frame 1581     EC 3.4.21.48
dJ223E3.12     

External Ids:    HGNC: 213871   Entrez Gene: 1676812   Ensembl: ENSG000001462507   UniProtKB: Q8N3Z03   

Export aliases for PRSS35 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRSS35 Gene:
PRSS35 (protease, serine, 35) is a protein-coding gene. An important paralog of this gene is PRSS23.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRSS35 gene promoter:
         TBP   Cdc5   Evi-1   AREB6   PPAR-gamma1   POU2F1   FOXJ2 (long isoform)   POU2F1a   FOXJ2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS35 promoter sequence
   Search Chromatin IP Primers for PRSS35

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.2   Ensembl cytogenetic band:  6q14.2   HGNC cytogenetic band: 6q14.2

PRSS35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS35 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P084278:  view genomic region     (about GC identifiers)

Start:
84,222,194 bp from pter      End:
84,235,423 bp from pter
Size:
13,230 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRS35_HUMAN, Q8N3Z0 (See protein sequence)
Recommended Name: Inactive serine protease 35 precursor  
Size: 413 amino acids; 47098 Da
Caution: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 346 which is
replaced by a Thr, suggesting that it has no protease activity
Secondary accessions: A8K7B3 Q9BQP6

Explore the universe of human proteins at neXtProt for PRSS35: NX_Q8N3Z0

Explore proteomics data for PRSS35 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn90
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for PRSS35 (Q8N3Z0)
     VLTAAHC  DYDYALLEL 


    See PRSS35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001163894.1  NP_699193.2  

    ENSEMBL proteins: 
     ENSP00000358714   ENSP00000440870  

    PRSS35 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PRSS35
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    Novus Biologicals PRSS35 Protein
    Novus Biologicals PRSS35 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRSS35

     
    Search eBioscience for Proteins for PRSS35 

    PRSS35 Antibody Products:

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    Abcam antibodies for PRSS35
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    ThermoFisher Antibody for PRSS35
    LSBio Antibodies in human, mouse, rat for PRSS35

    PRSS35 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PRSS35
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRSS35
    Cloud-Clone Corp. CLIAs for PRSS35
    Search eBioscience for ELISAs for PRSS35 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    3 InterPro protein domains:
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q8N3Z0

    ProtoNet protein and cluster: Q8N3Z0

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRS35_HUMAN, Q8N3Z0
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PRSS35           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0004252serine-type endopeptidase activity ----
         
    Find genes that share ontologies with PRSS35           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRSS35:
     G0/1 arrest  Increased G1 DNA content 

         1 MGI phenotypic allele for Prss35 (no phenotypes)

    Find genes that share phenotypes with PRSS35           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS35
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRSS35

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRSS35
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRSS35

    miRNA
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    Block miRNA regulation of human, mouse, rat PRSS35 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRSS35 (see all 19):
    hsa-miR-125a-5p hsa-miR-4251 hsa-miR-1297 hsa-miR-629* hsa-miR-125b hsa-miR-376a* hsa-miR-548x hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidPRSS35 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRSS35
    Predesigned siRNA for gene silencing in human, mouse, rat PRSS35

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PRSS35

    Clone
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    OriGene clones in human, mouse for PRSS35 (see all 11)
    OriGene ORF clones in mouse, rat for PRSS35
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRSS35 (NM_153362)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS35
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS35

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PRSS35 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS35


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRS35_HUMAN, Q8N3Z0: Secreted (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with PRSS35           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS35
    Interactions:

        Search GeneGlobe Interaction Network for PRSS35

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PRSS35 (ENSP000003587144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    ODF2LENSP000003595984STRING: ENSP00000359598
    --ENSP000002811894STRING: ENSP00000281189
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with PRSS35           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS35 (PRS35)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRSS35 gene (2 alternative transcripts): 
    NM_001170423.1  NM_153362.2  

    Unigene Cluster for PRSS35:

    Protease, serine, 35
    Hs.98381  [show with all ESTs]
    Unigene Representative Sequence: NM_001170423
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369700 ENST00000536636(uc010kbm.3 uc003pjz.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRSS35 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRSS35 (see all 19):
    hsa-miR-125a-5p hsa-miR-4251 hsa-miR-1297 hsa-miR-629* hsa-miR-125b hsa-miR-376a* hsa-miR-548x hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidPRSS35 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRSS35
    Predesigned siRNA for gene silencing in human, mouse, rat PRSS35
    Clone
    Products:
         
    OriGene clones in human, mouse for PRSS35 (see all 11)
    OriGene ORF clones in mouse, rat for PRSS35
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRSS35 (NM_153362)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS35
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS35
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRSS35
    OriGene qSTAR qPCR primer pairs in human, mouse for PRSS35
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRSS35
      QuantiTect SYBR Green Assays in human, mouse, rat PRSS35
      QuantiFast Probe-based Assays in human, mouse, rat PRSS35

    Additional mRNA sequence: 

    AK291928.1 AY358661.1 BC037170.1 

    3 DOTS entries:

    DT.310830  DT.95338469  DT.100673865 

    Selected AceView cDNA sequences (see all 28):

    CR615063 AI266636 BC037170 AA423988 AA424028 NM_153362 AA702780 AY358661 
    BI913028 AA483361 BX350107 CA414746 AA424073 AA445948 AI266634 AA452037 
    AL551286 AI424866 AI271571 BI552165 BX389627 AL574912 AA453213 AA742931 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS35    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for PRSS35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRSS35 Expression
    About this image


    PRSS35 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
    PRSS35 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS35 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98381
        Custom PCR Arrays for PRSS35
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS35 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss351 , 5 protease, serine, 355
    protease, serine 351
    78.32(n)1
    78(a)1
      9 (46.58 cM)5
    2449541  NM_178738.31  NP_848853.21 
     867436335 
    chicken
    (Gallus gallus)
    Aves PRSS351 protease, serine, 35 70.39(n)
    70.63(a)
      421839  XM_004940410.1  XP_004940467.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRSS356
    protease, serine, 35
    66(a)
    1 ↔ 1
    1(197521220-197522467)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prss351 protease, serine, 35 62.47(n)
    60.53(a)
      100490438  XM_004914525.1  XP_004914582.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prss351 protease, serine, 35 60.23(n)
    56.66(a)
      431759  NM_001002212.1  NP_001002212.1 


    ENSEMBL Gene Tree for PRSS35 (if available)
    TreeFam Gene Tree for PRSS35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS35 gene
    PRSS232  
    1 SIMAP similar gene for PRSS35 using alignment to 1 protein entry:     PRS35_HUMAN:
    PRSS23

    Find genes that share paralogs with PRSS35           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS35 (see all 330)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859508901,2
    --84220220(+) CCTGGA/GAGGTG 2 -- us2k10--------
    rs122043181,2
    C,F,H--84220405(+) AATACG/AAAGCA 2 -- us2k126Minor allele frequency- A:0.20NS EA NA WA 2910
    rs1897934001,2
    --84220422(+) CCAGAC/TGAAGT 2 -- us2k10--------
    rs93419601,2
    C,F,A,H--84220535(+) GGGCAT/GGAAAA 2 -- us2k1 tfbs317Minor allele frequency- G:0.19NS EA NA WA 2340
    rs1162314851,2
    C,F--84220613(+) GACCTG/CGGTCC 2 -- us2k11Minor allele frequency- C:0.14WA 118
    rs781534691,2
    C,F--84220747(+) CACAGC/TTATTT 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs737515371,2
    C,F--84220763(+) CAGGCG/AGAATT 2 -- us2k12Minor allele frequency- A:0.08WA 120
    rs93419611,2
    C,F,A,H--84220770(+) AATTCC/TCATTC 2 -- us2k1 tfbs328Minor allele frequency- T:0.25EA NA NS CSA WA 2972
    rs1507899771,2
    --84220802(+) GACTTC/TTCCAC 2 -- us2k10--------
    rs1813968531,2
    --84220812(+) CACTCA/CATCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRSS35 (84222194 - 84235423 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRSS35:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv996120CNV Deletion20482838
    nsv518229CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRSS35
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS35

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with PRSS35           About GenesLikeMe

    Genetic Association Database (GAD): PRSS35
    Human Genome Epidemiology (HuGE) Navigator: PRSS35 (2 documents)

    Export disorders for PRSS35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS35 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with PRSS35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Novel cleft susceptibility genes in chromosome 6q. (PubMed id 20511563)1, 4 Letra A....Vieira A.R. (J. Dent. Res. 2010)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PubMed id 16870946)1, 9 Miyakoshi K....Hennebold J.D. (Biol. Reprod. 2006)
    5. Genome-wide association of mood-incongruent psychotic bipolar disorder. (PubMed id 23092984)1 Goes F.S....Potash J.B. (Transl Psychiatry 2012)
    6. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 167681 HGNC: 21387 AceView: PRSS35 Ensembl:ENSG00000146250 euGenes: HUgn167681
    ECgene: PRSS35 H-InvDB: PRSS35

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS35 gene:
    Search GeneIP for patents involving PRSS35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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