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Aliases for PRSS3 Gene

Aliases for PRSS3 Gene

  • Protease, Serine 3 2 3 5
  • Protease, Serine, 4 (Trypsin 4, Brain) 2 3
  • Brain Trypsinogen 3 4
  • Mesotrypsinogen 3 4
  • Mesotrypsin 2 3
  • Trypsin III 3 4
  • EC 4 63
  • Trypsin IV 3 4
  • PRSS4 3 4
  • TRY4 3 4
  • TRY3 3 4
  • Protease, Serine, 3 (Mesotrypsin) 2
  • Pancreatic Trypsinogen III 3
  • Serine Protease 3 4
  • Serine Protease 4 4
  • Trypsinogen IV 3
  • Trypsinogen 4 3
  • Trypsinogen 5 3
  • EC 3.4.21 63
  • MTG 3
  • T9 3

External Ids for PRSS3 Gene

Previous HGNC Symbols for PRSS3 Gene

  • PRSS4

Previous GeneCards Identifiers for PRSS3 Gene

  • GC09P034062
  • GC09P033919
  • GC09P033740
  • GC09P033708

Summaries for PRSS3 Gene

Entrez Gene Summary for PRSS3 Gene

  • This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for PRSS3 Gene

PRSS3 (Protease, Serine 3) is a Protein Coding gene. Diseases associated with PRSS3 include Thyroiditis and Pancreatitis, Hereditary. Among its related pathways are Immune System and Pancreatic secretion. GO annotations related to this gene include calcium ion binding and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for PRSS3 Gene

  • Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS3 Gene

Genomics for PRSS3 Gene

Regulatory Elements for PRSS3 Gene

Enhancers for PRSS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS3 on UCSC Golden Path with GeneCards custom track

Promoters for PRSS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRSS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS3 Gene

33,750,466 bp from pter
33,799,231 bp from pter
48,766 bases
Plus strand

Genomic View for PRSS3 Gene

Genes around PRSS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS3 Gene

Proteins for PRSS3 Gene

  • Protein details for PRSS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8CED1
    • A8CED3
    • A9Z1Y4
    • E7ES07
    • F8W7P3
    • P15951
    • Q15665
    • Q5VXV0
    • Q6ISJ4
    • Q9UQV3

    Protein attributes for PRSS3 Gene

    304 amino acids
    Molecular mass:
    32529 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRSS3 Gene

    Alternative splice isoforms for PRSS3 Gene


neXtProt entry for PRSS3 Gene

Proteomics data for PRSS3 Gene at MOPED

Post-translational modifications for PRSS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRSS3 Gene

Antibody Products

  • R&D Systems Antibodies for PRSS3 (Trypsin 3/PRSS3)
  • Abcam antibodies for PRSS3

Domains & Families for PRSS3 Gene

Gene Families for PRSS3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS3: view

Function for PRSS3 Gene

Molecular function for PRSS3 Gene

GENATLAS Biochemistry:
protease serine 3,trypsin 3,expressed in brain
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa.
UniProtKB/Swiss-Prot Function:
Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.

Enzyme Numbers (IUBMB) for PRSS3 Gene

Gene Ontology (GO) - Molecular Function for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 6698368
genes like me logo Genes that share ontologies with PRSS3: view
genes like me logo Genes that share phenotypes with PRSS3: view

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS3 Gene

Localization for PRSS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS3 Gene


Subcellular locations from

Jensen Localization Image for PRSS3 Gene COMPARTMENTS Subcellular localization image for PRSS3 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PRSS3: view

Pathways & Interactions for PRSS3 Gene

genes like me logo Genes that share pathways with PRSS3: view

Gene Ontology (GO) - Biological Process for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0031638 zymogen activation IDA 6698368
GO:0043542 endothelial cell migration IMP 15313892
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with PRSS3: view

No data available for SIGNOR curated interactions for PRSS3 Gene

Drugs & Compounds for PRSS3 Gene

(14) Drugs for PRSS3 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]Guanidine Experimental Pharma Target 0
[4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine Experimental Pharma Target 0
1,3,2-Dioxaborolan-2-Ol Experimental Pharma Target 0
4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium Experimental Pharma Target 0
4-(Hydroxymethyl)Benzamidine Experimental Pharma Target 0

(2) Additional Compounds for PRSS3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRSS3: view

Transcripts for PRSS3 Gene

Unigene Clusters for PRSS3 Gene

Protease, serine, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: -

Relevant External Links for PRSS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS3 Gene

mRNA expression in normal human tissues for PRSS3 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS3 Gene

This gene is overexpressed in Pancreas (x45.7).

Protein differential expression in normal tissues from HIPED for PRSS3 Gene

This gene is overexpressed in Pancreatic juice (50.1) and Ovary (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS3 Gene

SOURCE GeneReport for Unigene cluster for PRSS3 Gene Hs.654513

mRNA Expression by UniProt/SwissProt for PRSS3 Gene

Tissue specificity: Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts.
genes like me logo Genes that share expression patterns with PRSS3: view

Primer Products

No data available for Protein tissue co-expression partners for PRSS3 Gene

Orthologs for PRSS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Try5 35
  • 82.52 (n)
  • 78.86 (a)
Try5 16
Gm10334 36
  • 76 (a)
Gm5771 36
  • 76 (a)
Prss1 36
  • 76 (a)
Prss2 36
  • 73 (a)
Prss3 36
  • 75 (a)
Try10 36
  • 76 (a)
Try4 36
  • 76 (a)
Try5 36
  • 76 (a)
(Pan troglodytes)
Mammalia LOC100615846 35
  • 93.66 (n)
  • 91.09 (a)
-- 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Try4 35
  • 82.93 (n)
  • 78.05 (a)
(Bos Taurus)
Mammalia PRSS2 36
  • 74 (a)
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
-- 36
  • 71 (a)
-- 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 64 (a)
-- 36
  • 67 (a)
-- 36
  • 69 (a)
(Gallus gallus)
Aves -- 36
  • 63 (a)
-- 36
  • 53 (a)
PRSS2 36
  • 66 (a)
PRSS3 36
  • 57 (a)
PRSS3 36
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
-- 36
  • 63 (a)
-- 36
  • 67 (a)
-- 36
  • 57 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64344 35
(Danio rerio)
Actinopterygii try 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17239 37
  • 36 (a)
CG17571 37
  • 36 (a)
CG4386 37
  • 42 (a)
CG5197 37
  • 37 (a)
CG6041 37
  • 38 (a)
CG7829 37
  • 33 (a)
CG8299 37
  • 39 (a)
eegrTry 37
  • 33 (a)
egrTry 37
  • 36 (a)
kgrTry 37
  • 33 (a)
lgrTry 37
  • 37 (a)
Try29F 37
  • 41 (a)
CG31954 35
  • 52.23 (n)
  • 44.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
-- 36
  • 43 (a)
-- 36
  • 44 (a)
CSA.4402 36
  • 43 (a)
CSA.4556 36
  • 44 (a)
Species with no ortholog for PRSS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS3 Gene

Gene Tree for PRSS3 (if available)
Gene Tree for PRSS3 (if available)

Paralogs for PRSS3 Gene Pseudogenes for PRSS3 Gene

genes like me logo Genes that share paralogs with PRSS3: view

Variants for PRSS3 Gene

Sequence variations from dbSNP and Humsavar for PRSS3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs855581 - 33,798,019(+) CCACC(A/G)CCCCT reference, missense
rs1048379 - 33,798,555(+) CTCCT(A/G)CCCTG reference, missense
rs1063273 - 33,798,531(+) GCTGA(C/G)CCAGG reference, missense
VAR_067459 -
rs695230 -- 33,789,360(+) GGTCA(C/T)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS3 Gene

Variant ID Type Subtype PubMed ID
nsv471653 CNV Gain 15918152
nsv893027 CNV Gain 21882294
nsv518977 CNV Gain 19592680
nsv893028 CNV Gain 21882294
nsv824910 CNV Loss 20364138
nsv8444 CNV Loss 18304495
esv24699 CNV Loss 19812545
esv2738377 CNV Deletion 23290073
esv2738378 CNV Deletion 23290073
esv2738379 CNV Deletion 23290073

Variation tolerance for PRSS3 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRSS3 Gene

Disorders for PRSS3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PRSS3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • pancreatitis, chronic
autoimmune disease of endocrine system
3mc syndrome
  • craniofacial-ulnar-renal syndrome
thyroid gland disease
  • thyroid diseases
- elite association - COSMIC cancer census association via MalaCards
Search PRSS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRSS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRSS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS3 Gene

Publications for PRSS3 Gene

  1. Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. (PMID: 8294000) Wiegand U. … Mueller-Hill B. (Gene 1993) 2 3 4 67
  2. The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin. (PMID: 19920152) Salameh M.A. … Radisky E.S. (J. Biol. Chem. 2010) 3 23
  3. Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation. (PMID: 19924134) Nakanishi J. … Hibino T. (J. Invest. Dermatol. 2010) 3 23
  4. Absence of mesotrypsinogen gene (PRSS3) copy number variations in patients with chronic pancreatitis. (PMID: 18665091) Masson E. … FAcrec C. (Pancreas 2008) 3 23
  5. Regional distribution of human trypsinogen 4 in human brain at mRNA and protein level. (PMID: 17406981) TA^th J. … Palkovits M. (Neurochem. Res. 2007) 3 23

Products for PRSS3 Gene

Sources for PRSS3 Gene