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Aliases for PRSS3 Gene

Aliases for PRSS3 Gene

  • Protease, Serine, 3 2 3
  • TRY3 3 4 6
  • Protease, Serine, 4 (Trypsin 4, Brain) 2 3
  • Brain Trypsinogen 3 4
  • Mesotrypsinogen 3 4
  • Mesotrypsin 2 3
  • Trypsin III 3 4
  • EC 3.4.21.4 4 63
  • Trypsin IV 3 4
  • PRSS4 3 4
  • TRY4 3 4
  • T9 3 6
  • Protease, Serine, 3 (Mesotrypsin) 2
  • Pancreatic Trypsinogen III 3
  • Serine Protease 3 4
  • Serine Protease 4 4
  • Trypsinogen IV 3
  • Trypsinogen 4 3
  • Trypsinogen 5 3
  • Trypsin-3 3
  • EC 3.4.21 63
  • MTG 3

External Ids for PRSS3 Gene

Previous HGNC Symbols for PRSS3 Gene

  • PRSS4

Previous GeneCards Identifiers for PRSS3 Gene

  • GC09P034062
  • GC09P033919
  • GC09P033740
  • GC09P033708

Summaries for PRSS3 Gene

Entrez Gene Summary for PRSS3 Gene

  • This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for PRSS3 Gene

PRSS3 (Protease, Serine, 3) is a Protein Coding gene. Diseases associated with PRSS3 include pancreatitis, hereditary. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include calcium ion binding and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for PRSS3 Gene

  • Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS3 Gene

Genomics for PRSS3 Gene

Regulatory Elements for PRSS3 Gene

Genomic Location for PRSS3 Gene

Start:
33,750,466 bp from pter
End:
33,799,231 bp from pter
Size:
48,766 bases
Orientation:
Plus strand

Genomic View for PRSS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS3 Gene

Proteins for PRSS3 Gene

  • Protein details for PRSS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35030-TRY3_HUMAN
    Recommended name:
    Trypsin-3
    Protein Accession:
    P35030
    Secondary Accessions:
    • A8CED1
    • A8CED3
    • A9Z1Y4
    • E7ES07
    • F8W7P3
    • P15951
    • Q15665
    • Q5VXV0
    • Q6ISJ4
    • Q9UQV3

    Protein attributes for PRSS3 Gene

    Size:
    304 amino acids
    Molecular mass:
    32529 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRSS3 Gene

    Alternative splice isoforms for PRSS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS3 Gene

Proteomics data for PRSS3 Gene at MOPED

Post-translational modifications for PRSS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRSS3 Gene

Domains for PRSS3 Gene

Gene Families for PRSS3 Gene

HGNC:
  • PRSS :Serine peptidases / Serine peptidases

Graphical View of Domain Structure for InterPro Entry

P35030

UniProtKB/Swiss-Prot:

TRY3_HUMAN :
  • P35030
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS3: view

Function for PRSS3 Gene

Molecular function for PRSS3 Gene

GENATLAS Biochemistry: protease serine 3,trypsin 3,expressed in brain
UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa
UniProtKB/Swiss-Prot Function: Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.

Enzyme Numbers (IUBMB) for PRSS3 Gene

Gene Ontology (GO) - Molecular Function for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IDA 14507909
GO:0005509 calcium ion binding IDA 6698368
GO:0005515 protein binding IPI 14507909
GO:0008236 serine-type peptidase activity IDA 9099703
genes like me logo Genes that share ontologies with PRSS3: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRSS3 Gene

Localization for PRSS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS3 Gene COMPARTMENTS Subcellular localization image for PRSS3 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 6698368
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PRSS3: view

Pathways for PRSS3 Gene

SuperPathways for PRSS3 Gene

genes like me logo Genes that share pathways with PRSS3: view

Gene Ontology (GO) - Biological Process for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 8294000
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0007586 digestion TAS 14507909
GO:0009235 cobalamin metabolic process TAS --
genes like me logo Genes that share ontologies with PRSS3: view

Compounds for PRSS3 Gene

(1) HMDB Compounds for PRSS3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(6) Novoseek inferred chemical compound relationships for PRSS3 Gene

Compound -log(P) Hits PubMed IDs
thyronine 84.7 1
trypsinogen 77 4
serine 36.1 3
thyroxine 27.7 2
arginine 26.4 2
genes like me logo Genes that share compounds with PRSS3: view

Transcripts for PRSS3 Gene

Unigene Clusters for PRSS3 Gene

Protease, serine, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: -
SP3:

Relevant External Links for PRSS3 Gene

GeneLoc Exon Structure for
PRSS3
ECgene alternative splicing isoforms for
PRSS3

Expression for PRSS3 Gene

mRNA expression in normal human tissues for PRSS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS3 Gene

This gene is overexpressed in Pancreas (45.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRSS3 Gene

SOURCE GeneReport for Unigene cluster for PRSS3 Gene Hs.654513

mRNA Expression by UniProt/SwissProt for PRSS3 Gene

P35030-TRY3_HUMAN
Tissue specificity: Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts.
genes like me logo Genes that share expressions with PRSS3: view

Orthologs for PRSS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 89 (a)
ManyToMany
LOC100615846 35
  • 93.66 (n)
  • 91.09 (a)
cow
(Bos Taurus)
Mammalia PRSS2 36
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm10334 36
  • 76 (a)
ManyToMany
Gm5771 36
  • 76 (a)
ManyToMany
Prss1 36
  • 76 (a)
ManyToMany
Prss2 36
  • 73 (a)
ManyToMany
Prss3 16
Prss3 36
  • 75 (a)
ManyToMany
Try10 36
  • 76 (a)
ManyToMany
Try4 36
  • 76 (a)
ManyToMany
Try5 35
  • 82.52 (n)
  • 78.86 (a)
Try5 36
  • 76 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Try4 35
  • 82.93 (n)
  • 78.05 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 63 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
PRSS2 36
  • 66 (a)
ManyToMany
PRSS3 36
  • 57 (a)
ManyToMany
PRSS3 36
  • 65 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64344 35
zebrafish
(Danio rerio)
Actinopterygii try 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31954 35
  • 52.23 (n)
  • 44.24 (a)
CG5197 37
  • 37 (a)
Try29F 37
  • 41 (a)
eegrTry 37
  • 33 (a)
CG17571 37
  • 36 (a)
lgrTry 37
  • 37 (a)
CG4386 37
  • 42 (a)
kgrTry 37
  • 33 (a)
CG17239 37
  • 36 (a)
egrTry 37
  • 36 (a)
CG7829 37
  • 33 (a)
CG6041 37
  • 38 (a)
CG8299 37
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
CSA.4402 36
  • 43 (a)
ManyToMany
CSA.4556 36
  • 44 (a)
ManyToMany
Species with no ortholog for PRSS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS3 Gene

ENSEMBL:
Gene Tree for PRSS3 (if available)
TreeFam:
Gene Tree for PRSS3 (if available)

Paralogs for PRSS3 Gene

Pseudogenes.org Pseudogenes for PRSS3 Gene

genes like me logo Genes that share paralogs with PRSS3: view

Variants for PRSS3 Gene

Sequence variations from dbSNP and Humsavar for PRSS3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs706137 -- 33,780,374(+) aattt(A/G)tttta intron-variant
rs855417 -- 33,776,886(+) AATAT(A/T)AAAAA intron-variant
rs855418 -- 33,777,681(+) ccacc(C/T)tgggc intron-variant
rs855419 -- 33,761,288(+) GTAGG(C/T)GTGAG intron-variant
rs855466 -- 33,769,475(+) TTTTT(C/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS3 Gene

Variant ID Type Subtype PubMed ID
nsv471653 CNV Gain 15918152
nsv893027 CNV Gain 21882294
nsv518977 CNV Gain 19592680
nsv893028 CNV Gain 21882294
nsv824910 CNV Loss 20364138
nsv8444 CNV Loss 18304495
esv24699 CNV Loss 19812545
esv2738377 CNV Deletion 23290073
esv2738378 CNV Deletion 23290073
esv2738379 CNV Deletion 23290073

Relevant External Links for PRSS3 Gene

HapMap Linkage Disequilibrium report
PRSS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS3 Gene

Disorders for PRSS3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PRSS3 Gene including...

Search for PRSS3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for PRSS3 Gene

(11) Novoseek inferred disease relationships for PRSS3 Gene

Disease -log(P) Hits PubMed IDs
thyroiditis 86.5 10
pancreatitis hereditary 63.8 1
hashimotos thyroiditis 60.1 1
autoimmunity 43.6 1
autoimmune diseases 38 1

Relevant External Links for PRSS3

Genetic Association Database (GAD)
PRSS3
Human Genome Epidemiology (HuGE) Navigator
PRSS3
genes like me logo Genes that share disorders with PRSS3: view

No data available for UniProtKB/Swiss-Prot for PRSS3 Gene

Publications for PRSS3 Gene

  1. Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors. (PMID: 14507909) Szmola R. … Sahin-Toth M. (J. Biol. Chem. 2003) 3 4 23
  2. Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen. (PMID: 15855826) Nemoda Z. … Sahin-TA^th M. (Pancreatology 2005) 3 23 48
  3. Crystal structure reveals basis for the inhibitor resistance of human brain trypsin. (PMID: 11827488) Katona G. … Szilagyi L. (J. Mol. Biol. 2002) 3 4 23
  4. Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation. (PMID: 19924134) Nakanishi J. … Hibino T. (J. Invest. Dermatol. 2010) 3 4 23
  5. Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. (PMID: 8294000) Wiegand U. … Mueller-Hill B. (Gene 1993) 2 3 4

Products for PRSS3 Gene

Sources for PRSS3 Gene

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