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PRSS3 Gene

protein-coding   GIFtS: 66
GCID: GC09P033750

Protease, Serine, 3

(Previous names: protease, serine, 4 (trypsin 4, brain), protease, serine,...)
(Previous symbol: PRSS4)
  Search for PRSS3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 31 2     MTG2
PRSS41 2 3     mesotrypsinogen2
TRY32 3 5     Pancreatic Trypsinogen III2
Protease, Serine, 4 (Trypsin 4, Brain)1 2     trypsin-32
mesotrypsin1 2     Trypsinogen 42
Brain Trypsinogen2 3     Trypsinogen 52
Trypsin III2 3     Trypsinogen IV2
Trypsin IV2 3     Mesotrypsinogen3
TRY42 3     Serine Protease 33
EC 3.4.21.43 8     Serine Protease 43
T92 5     EC 3.4.218
Protease, Serine, 3 (Mesotrypsin)1     

External Ids:    HGNC: 94861   Entrez Gene: 56462   Ensembl: ENSG000000104387   OMIM: 6135785   UniProtKB: P350303   

Export aliases for PRSS3 gene to outside databases

Previous GC identifers: GC09P034062 GC09P033919 GC09P033740 GC09P033708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRSS3 Gene:
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is
expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide
linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell
receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been
described for this gene. (provided by RefSeq, Oct 2010)

GeneCards Summary for PRSS3 Gene:
PRSS3 (protease, serine, 3) is a protein-coding gene. GO annotations related to this gene include serine-type peptidase activity and calcium ion binding. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: TRY3_HUMAN, P35030
Function: Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved
in defensin processing, including DEFA5




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRSS3 gene promoter:
         AREB6   AML1a   Nkx5-1   Tal-1beta   ITF-2   Zic3   C/EBPalpha   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS3 promoter sequence
   Search Chromatin IP Primers for PRSS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p11.2   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

PRSS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033750:  view genomic region     (about GC identifiers)

Start:
33,750,464 bp from pter      End:
33,799,230 bp from pter
Size:
48,767 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRY3_HUMAN, P35030 (See protein sequence)
Recommended Name: Trypsin-3 precursor  
Size: 304 amino acids; 32529 Da
Cofactor: Binds 1 calcium ion per subunit
Selected PDB 3D structures from and Proteopedia for PRSS3 (see all 7):
1H4W (3D)        2R9P (3D)        3L33 (3D)        3L3T (3D)        3P92 (3D)        3P95 (3D)    
Secondary accessions: A8CED1 A8CED3 A9Z1Y4 E7ES07 F8W7P3 P15951 Q15665 Q5VXV0 Q6ISJ4 Q9UQV3
Alternative splicing: 5 isoforms:  P35030-1   P35030-2   P35030-3   P35030-4   P35030-5   

Explore the universe of human proteins at neXtProt for PRSS3: NX_P35030

Explore proteomics data for PRSS3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRSS3 (P35030) (see all 20)
     EGGKDSC  PGVYTKV  IQVRLGE  DIMLIKL 


    See PRSS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001184026.2  NP_001184027.1  NP_002762.2  NP_031369.2  

    ENSEMBL proteins: 
     ENSP00000354280   ENSP00000401249   ENSP00000368715   ENSP00000401828   ENSP00000340889  
    Reactome Protein details: P35030

    PRSS3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P35030

    ProtoNet protein and cluster: P35030

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TRY3_HUMAN, P35030
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PRSS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRY3_HUMAN, P35030
    Function: Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved
    in defensin processing, including DEFA5
    Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa

         Genatlas biochemistry entry for PRSS3:
    protease serine 3,trypsin 3,expressed in brain

         Enzyme Numbers (IUBMB): EC 3.4.21.41 2 EC 3.4.212

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IDA14507909
    GO:0005509calcium ion binding IDA6698368
    GO:0005515protein binding IPI14507909
    GO:0008236serine-type peptidase activity IDA9099703
         
    Find genes that share ontologies with PRSS3           About GenesLikeMe


    Animal Models:
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    Sino Biological Human cDNA Clone for PRSS3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRY3_HUMAN, P35030: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    mitochondrion2
    endoplasmic reticulum1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA6698368

    Find genes that share ontologies with PRSS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRSS3 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    2Defensins
    Defensins0.80
    Alpha-defensins0.00
    3Metabolism
    Metabolism0.38
    4Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    5Influenza A
    Influenza A0.34


    Find genes that share SuperPaths with PRSS3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for PRSS3
        Cobalamin (Cbl, vitamin B12) transport and metabolism
    Alpha-defensins


    4 Kegg Pathways  (Kegg details for PRSS3):
        Neuroactive ligand-receptor interaction
    Pancreatic secretion
    Protein digestion and absorption
    Influenza A

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS3
    Interactions:

        Search GeneGlobe Interaction Network for PRSS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for PRSS3 (P350303 ENSP000003542804) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TFPIP106463, ENSP000002331564I2D: score=2 STRING: ENSP00000233156
    SERPINA1P010093, ENSP000003480684I2D: score=1 STRING: ENSP00000348068
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
    APCP250543I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS8294000
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0007586digestion TAS14507909
    GO:0009235cobalamin metabolic process TAS--

    Find genes that share ontologies with PRSS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS3 (TRY3)

    1 HMDB Compound for PRSS3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    8 DrugBank Compounds for PRSS3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,3,2-Dioxaborolan-2-Ol-- --target--17139284 17016423 10592235
    4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium-- --target--17139284 17016423 10592235
    4-(Hydroxymethyl)Benzamidine-- --target--17139284 17016423 10592235
    4-Hydroxybutan-1-Aminium-- --target--17139284 17016423 10592235
    Guanidine-3-Propanol-- --target--17139284 17016423 10592235
    Benzamidine-- 618-39-3target--17139284 17016423
    [3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]Guanidine-- --target--10592235
    [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine-- --target--10592235

    6 Novoseek inferred chemical compound relationships for PRSS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyronine 84.7 1 9609129 (1)
    trypsinogen 77 5 15901841 (3), 9832635 (1)
    serine 36.1 5 16903872 (1), 19766328 (1), 17614969 (1)
    thyroxine 27.7 4 9609129 (1), 9434803 (1)
    arginine 26.4 2 14507909 (1), 18077447 (1)
    iodine 14.3 1 10087179 (1)



    Find genes that share compounds with PRSS3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRSS3 gene (4 alternative transcripts): 
    NM_001197097.2  NM_001197098.1  NM_002771.3  NM_007343.3  

    Unigene Cluster for PRSS3:

    Protease, serine, 3
    Hs.654513  [show with all ESTs]
    Unigene Representative Sequence: BQ687514
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361005(uc003zti.4 uc003ztj.4) ENST00000468152 ENST00000457896
    ENST00000379405(uc003ztl.4) ENST00000477653 ENST00000495682 ENST00000429677(uc022bfu.1)
    ENST00000342836
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    Additional mRNA sequence: 

    AB298285.1 AB298286.1 AY052783.1 BC030238.1 BC069476.1 BC069494.1 D45417.1 X15505.1 
    X71345.1 X72781.1 

    12 DOTS entries:

    DT.95259198  DT.99960247  DT.121210997  DT.95331769  DT.97862758  DT.100043423  DT.100045920  DT.100828691 
    DT.100828698  DT.75159559  DT.87078490  DT.91767689 

    Selected AceView cDNA sequences (see all 837):

    AA583856 CA433615 BM311360 BM511636 BQ416808 BM894077 AA308186 AA363463 
    BU785997 BQ690939 BQ632777 BU174450 BQ416974 BU196648 BM745471 BQ684952 
    BQ686516 BU147268 X72781 BQ689742 BG499859 BC069494 BU174337 BE314478 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:              -     -                                 
    SP2:                    -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for PRSS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGTGCCTG
    PRSS3 Expression
    About this image


    PRSS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    PRSS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654513

    UniProtKB/Swiss-Prot: TRY3_HUMAN, P35030
    Tissue specificity: Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small
    intestinal crypts

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRSS3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss35
    Try51
    protease, serine, 35
    trypsin 51
    82.52(n)1
    78.86(a)1
      6 (19.50 cM)5
    1039641  NM_001003405.41  NP_001003405.11 
     413737595 
    chicken
    (Gallus gallus)
    Aves PRSS26
    PRSS36
    (see all 5)
    Gallus gallus protease, serine, 3 (PRSS3), mRNA.
    (see all 5)
    66(a)
    65(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    AADN03009585.1(654-2195)
    1(77659665-77662349)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    67(a)
    63(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343499.1(516263-524830)
    GL343499.1(468698-476089)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643442 hypothetical protein MGC64344 78.31(n)    X53458.1 
    zebrafish
    (Danio rerio)
    Actinopterygii try6
    trypsin
    64(a)
    1 → many
    16(27320045-27324608) ENSDARG00000042993
    fruit fly
    (Drosophila melanogaster)
    Insecta CG43863
    CG319541
    serine-type endopeptidase3
    CG319541
    42(a)
    (best of 12)3
    52.23(n)1
    44.24(a)1
      58A13
    335721  NM_164543.41  NP_722915.11 


    ENSEMBL Gene Tree for PRSS3 (if available)
    TreeFam Gene Tree for PRSS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS3 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS12  
    PRSS582  KLK82  KLK32  
    Selected SIMAP similar genes for PRSS3 using alignment to 4 protein entries:     TRY3_HUMAN (see all proteins) (see all similar genes):
    PRSS1    PRSS2    TRY8    KLK5    KLK8    KLK6
    KLK7    KLK12    KLK14    KLK9    KLK1    KLK11
    KLK15    KLK4    KLK13    DKFZp586F0824    PRSS37    KLK10

    Find genes that share paralogs with PRSS3           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PRSS3
    PGOHUM00000233023 PGOHUM00000260385 PGOHUM00000258380


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS3 (see all 1035)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1930160101,2
    --33748536(+) AAGAGA/GCTGCC 2 -- us2k10--------
    rs1476964581,2
    --33748557(+) TGTGTA/CCTTCT 2 -- us2k10--------
    rs1849583301,2
    C--33748771(+) AGTAGA/GTCTGA 2 -- us2k10--------
    rs756758761,2
    F--33748784(+) GGGAGG/ACTTAG 2 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1423184131,2
    --33748818(+) GCACAG/TGGTTG 2 -- us2k10--------
    rs1179091931,2
    F--33748854(+) GAACCA/CTTCCA 3 -- us2k11Minor allele frequency- C:0.04EA 120
    rs1147405041,2
    C,F--33748861(+) TCCACG/AAGGCT 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs109716761,2
    C--33748874(+) GTGTCC/TGGAAT 3 -- us2k14Minor allele frequency- T:0.12NA WA EA 360
    rs8555831,2
    C,F--33748978(+) agtttG/Tttcct 3 -- us2k15Minor allele frequency- T:0.13NA MN WA CSA 191
    rs286028691,2
    C,F--33749155(+) CAGGGG/ATGAAG 3 -- us2k11Minor allele frequency- A:0.15WA 118

    HapMap Linkage Disequilibrium report for PRSS3 (33750464 - 33799230 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for PRSS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738378CNV Deletion23290073
    esv2738379CNV Deletion23290073
    esv2738377CNV Deletion23290073
    esv24699CNV Loss19812545
    nsv8444CNV Loss18304495
    nsv824910CNV Loss20364138
    nsv893027CNV Gain21882294
    nsv471653CNV Gain15918152
    nsv518977CNV Gain19592680
    nsv893028CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRSS3
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613578    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for PRSS3:
    Autoimmune thyroiditis     Pancreatitis

    Find genes that share disorders with PRSS3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRSS3 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroiditis 86.5 19 18489063 (2), 11129116 (1), 7505005 (1), 1634763 (1) (see all 9)
    pancreatitis hereditary 63.8 1 9832635 (1)
    hashimotos thyroiditis 60.1 1 9218533 (1)
    autoimmunity 43.6 1 17638915 (1)
    autoimmune diseases 38 1 17638915 (1)
    chronic pancreatitis 35.2 2 18665091 (1), 15855826 (1)
    pancreatitis 34.4 2 16029158 (1), 9832635 (1)
    astrocytoma 23.2 4 16231009 (2), 16903872 (1)
    inflammation 6.8 8 17623652 (3), 9609129 (1), 9588903 (1), 10541803 (1)
    tumors 0 3 19380836 (2), 17638915 (1)

    Genetic Association Database (GAD): PRSS3
    Human Genome Epidemiology (HuGE) Navigator: PRSS3 (4 documents)

    Export disorders for PRSS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS3 gene, integrated from 10 sources (see all 87):
    (articles sorted by number of sources associating them with PRSS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. (PubMed id 8294000)1, 2, 3 Wiegand U.... Mueller-Hill B. (Gene 1993)
    2. Nucleotide sequence of the human pancreatic trypsinogen III cDNA. (PubMed id 2326201)1, 2, 3 Tani T.... Takiguchi Y. (Nucleic Acids Res. 1990)
    3. Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors. (PubMed id 14507909)1, 2, 9 Szmola R.... Sahin-Toth M. (J. Biol. Chem. 2003)
    4. Crystal structure reveals basis for the inhibitor resistance of human brain trypsin. (PubMed id 11827488)1, 2, 9 Katona G.... Szilagyi L. (J. Mol. Biol. 2002)
    5. Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation. (PubMed id 19924134)1, 2, 9 Nakanishi J.... Hibino T. (J. Invest. Dermatol. 2010)
    6. Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen. (PubMed id 15855826)1, 4, 9 Nemoda Z....Sahin-TA^th M. (Pancreatology 2005)
    7. Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis. (PubMed id 20484962)1, 4 Rosendahl J....Witt H. (Pancreatology 2010)
    8. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PubMed id 18711365)1, 4 Ferreira M.A....Craddock N. (Nat. Genet. 2008)
    9. Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia. (PubMed id 17623652)1, 9 Knecht W....Bunnett N.W. (J. Biol. Chem. 2007)
    10. Human mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chains. (PubMed id 16759229)1, 9 Szepessy E. and Sahin-TA^th M. (FEBS J. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5646 HGNC: 9486 AceView: PRSS3 Ensembl:ENSG00000010438 euGenes: HUgn5646
    ECgene: PRSS3 Kegg: 5646 H-InvDB: PRSS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRSS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS3 gene:
    Search GeneIP for patents involving PRSS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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