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Aliases for PRSS3 Gene

Aliases for PRSS3 Gene

  • Protease, Serine 3 2 3 5
  • Protease, Serine, 4 (Trypsin 4, Brain) 2 3
  • Brain Trypsinogen 3 4
  • Mesotrypsinogen 3 4
  • Mesotrypsin 2 3
  • Trypsin III 3 4
  • EC 4 61
  • Trypsin IV 3 4
  • PRSS4 3 4
  • TRY4 3 4
  • TRY3 3 4
  • Protease, Serine, 3 (Mesotrypsin) 2
  • Pancreatic Trypsinogen III 3
  • Serine Protease 3 4
  • Serine Protease 4 4
  • Trypsinogen IV 3
  • Trypsinogen 4 3
  • Trypsinogen 5 3
  • Trypsin-3 3
  • EC 3.4.21 61
  • MTG 3
  • T9 3

External Ids for PRSS3 Gene

Previous HGNC Symbols for PRSS3 Gene

  • PRSS4

Previous GeneCards Identifiers for PRSS3 Gene

  • GC09P034062
  • GC09P033919
  • GC09P033740
  • GC09P033708

Summaries for PRSS3 Gene

Entrez Gene Summary for PRSS3 Gene

  • This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for PRSS3 Gene

PRSS3 (Protease, Serine 3) is a Protein Coding gene. Diseases associated with PRSS3 include Thyroiditis and Pancreatitis. Among its related pathways are Collagen chain trimerization and Innate Immune System. GO annotations related to this gene include calcium ion binding and serine-type peptidase activity. An important paralog of this gene is PRSS2.

UniProtKB/Swiss-Prot for PRSS3 Gene

  • Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS3 Gene

Genomics for PRSS3 Gene

Regulatory Elements for PRSS3 Gene

Enhancers for PRSS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G033613 0.3 FANTOM5 73.7 -136.4 -136448 0.2 PRSS3 LINC01251 ENSG00000260947 PRSS3P4 TRBV20OR9-2
GH09G033813 1.7 FANTOM5 ENCODE dbSUPER 7.4 +66.2 66246 6.9 HDGF HNRNPUL1 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 UBE2R2 UBAP1 PRSS3 ENSG00000260947 ENSG00000230074 UBAP2 DCAF12 GC09P034052
GH09G033749 1.3 Ensembl ENCODE dbSUPER 7.2 +1.5 1455 4.2 SOX13 TFAP4 FOXA2 SAP130 ARID4B MAX CEBPG YY1 EGR1 NCOR1 ENSG00000260947 TRBV26OR9-2 RNU4ATAC11P UBE2R2 UBAP2 LINC01251 PRSS3 ENSG00000227301 NOL6 TRBV29OR9-2
GH09G033721 1.3 Ensembl ENCODE 7.1 -28.3 -28287 0.8 HDGF WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ELK1 ZNF143 ZNF207 ENSG00000260947 AQP7 LOC105376020 PRSS3 ENSG00000227301 LOC102724216
GH09G034047 1.1 ENCODE 7.6 +298.3 298270 3.9 PKNOX1 CREB3L1 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 SMU1 ENSG00000228352 UBE2R2 PRSS3 ENSG00000260947 KIF24 C9orf24 DCAF12 OSTCP8 UBAP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRSS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS3 Gene

33,750,466 bp from pter
33,799,231 bp from pter
48,766 bases
Plus strand

Genomic View for PRSS3 Gene

Genes around PRSS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS3 Gene

Proteins for PRSS3 Gene

  • Protein details for PRSS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8CED1
    • A8CED3
    • A9Z1Y4
    • E7ES07
    • F8W7P3
    • P15951
    • Q15665
    • Q5VXV0
    • Q6ISJ4
    • Q9UQV3

    Protein attributes for PRSS3 Gene

    304 amino acids
    Molecular mass:
    32529 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRSS3 Gene

    Alternative splice isoforms for PRSS3 Gene


neXtProt entry for PRSS3 Gene

Selected DME Specific Peptides for PRSS3 Gene


Post-translational modifications for PRSS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for PRSS3 (Trypsin 3/PRSS3)
  • Abcam antibodies for PRSS3

Domains & Families for PRSS3 Gene

Gene Families for PRSS3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS3: view

Function for PRSS3 Gene

Molecular function for PRSS3 Gene

GENATLAS Biochemistry:
protease serine 3,trypsin 3,expressed in brain
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa.
UniProtKB/Swiss-Prot Function:
Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.

Enzyme Numbers (IUBMB) for PRSS3 Gene

Gene Ontology (GO) - Molecular Function for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IDA 6698368
GO:0005509 calcium ion binding IDA 6698368
GO:0005515 protein binding IPI 6698368
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS --
genes like me logo Genes that share ontologies with PRSS3: view
genes like me logo Genes that share phenotypes with PRSS3: view

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS3 Gene

Localization for PRSS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS3 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 6698368
GO:0070062 extracellular exosome IDA 23376485
GO:1904724 tertiary granule lumen TAS --
genes like me logo Genes that share ontologies with PRSS3: view

Pathways & Interactions for PRSS3 Gene

genes like me logo Genes that share pathways with PRSS3: view

Gene Ontology (GO) - Biological Process for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS,TAS 8294000
GO:0007586 digestion TAS 6698368
GO:0009235 cobalamin metabolic process TAS --
GO:0019730 antimicrobial humoral response TAS --
GO:0031638 zymogen activation IDA 6698368
genes like me logo Genes that share ontologies with PRSS3: view

No data available for SIGNOR curated interactions for PRSS3 Gene

Drugs & Compounds for PRSS3 Gene

(14) Drugs for PRSS3 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]Guanidine Experimental Pharma Target 0
[4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine Experimental Pharma Target 0
1,3,2-Dioxaborolan-2-Ol Experimental Pharma Target 0
4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium Experimental Pharma Target 0
4-(Hydroxymethyl)Benzamidine Experimental Pharma Target 0

(2) Additional Compounds for PRSS3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRSS3: view

Transcripts for PRSS3 Gene

Unigene Clusters for PRSS3 Gene

Protease, serine, 3:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: -

Relevant External Links for PRSS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS3 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS3 Gene

This gene is overexpressed in Pancreas (x45.7).

Protein differential expression in normal tissues from HIPED for PRSS3 Gene

This gene is overexpressed in Pancreatic juice (50.1) and Ovary (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS3 Gene:


SOURCE GeneReport for Unigene cluster for PRSS3 Gene:


mRNA Expression by UniProt/SwissProt for PRSS3 Gene:

Tissue specificity: Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts.

Evidence on tissue expression from TISSUES for PRSS3 Gene

  • Pancreas(4.8)
  • Nervous system(4.5)
  • Thyroid gland(2.5)
  • Intestine(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with PRSS3: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS3 Gene

Orthologs for PRSS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100615846 34
  • 93.66 (n)
-- 35
  • 89 (a)
(Rattus norvegicus)
Mammalia Try4 34
  • 82.93 (n)
(Mus musculus)
Mammalia Try5 34 16 35
  • 82.52 (n)
Gm10334 35
  • 76 (a)
Gm5771 35
  • 76 (a)
Prss1 35
  • 76 (a)
Try10 35
  • 76 (a)
Try4 35
  • 76 (a)
Prss3 35
  • 75 (a)
Prss2 35
  • 73 (a)
(Canis familiaris)
Mammalia -- 35
  • 77 (a)
(Bos Taurus)
Mammalia PRSS2 35
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
-- 35
  • 71 (a)
-- 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
-- 35
  • 67 (a)
-- 35
  • 65 (a)
-- 35
  • 64 (a)
(Gallus gallus)
Aves PRSS2 35
  • 66 (a)
-- 35
  • 63 (a)
PRSS3 35 35
  • 57 (a)
-- 35
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
-- 35
  • 63 (a)
-- 35
  • 57 (a)
-- 35
  • 42 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64344 34
(Danio rerio)
Actinopterygii try 35
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31954 34
  • 52.23 (n)
CG4386 36
  • 42 (a)
Try29F 36
  • 41 (a)
CG8299 36
  • 39 (a)
CG6041 36
  • 38 (a)
CG5197 36
  • 37 (a)
lgrTry 36
  • 37 (a)
CG17239 36
  • 36 (a)
CG17571 36
  • 36 (a)
egrTry 36
  • 36 (a)
CG7829 36
  • 33 (a)
eegrTry 36
  • 33 (a)
kgrTry 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
CSA.4556 35
  • 44 (a)
-- 35
  • 43 (a)
CSA.4402 35
  • 43 (a)
-- 35
  • 42 (a)
Species where no ortholog for PRSS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS3 Gene

Gene Tree for PRSS3 (if available)
Gene Tree for PRSS3 (if available)

Paralogs for PRSS3 Gene

genes like me logo Genes that share paralogs with PRSS3: view

Variants for PRSS3 Gene

Sequence variations from dbSNP and Humsavar for PRSS3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000098145 -- 33,784,988(+) AATAG(C/T)GTGAC intron-variant
rs1000339985 -- 33,792,448(+) TCTAG(C/T)ATGAT intron-variant
rs1000350529 -- 33,769,745(+) GGATG(-/C)CCCAG intron-variant
rs1000531925 -- 33,763,144(+) AATTC(A/G)GTTTC intron-variant
rs1000566988 -- 33,756,465(+) TCTTC(A/G)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS3 Gene

Variant ID Type Subtype PubMed ID
dgv7518n100 CNV gain 25217958
esv24699 CNV loss 19812545
esv2738377 CNV deletion 23290073
esv2738378 CNV deletion 23290073
esv2738379 CNV deletion 23290073
esv2761525 CNV gain 21179565
nsv1125318 OTHER inversion 24896259
nsv471653 CNV gain 15918152
nsv518977 CNV gain 19592680
nsv824910 CNV loss 20364138
nsv8444 CNV loss 18304495
nsv968607 CNV duplication 23825009
nsv968608 CNV duplication 23825009

Variation tolerance for PRSS3 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS3 Gene

Disorders for PRSS3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for PRSS3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • pancreatitis, chronic
hashimoto thyroiditis
  • autoimmune thyroiditis
3mc syndrome
  • craniofacial-ulnar-renal syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PRSS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRSS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRSS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS3 Gene

Publications for PRSS3 Gene

  1. Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation. (PMID: 19924134) Nakanishi J. … Hibino T. (J. Invest. Dermatol. 2010) 3 4 22 64
  2. Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen. (PMID: 15855826) Nemoda Z. … Sahin-TA^th M. (Pancreatology 2005) 3 22 46 64
  3. Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors. (PMID: 14507909) Szmola R. … Sahin-Toth M. (J. Biol. Chem. 2003) 3 4 22 64
  4. Crystal structure reveals basis for the inhibitor resistance of human brain trypsin. (PMID: 11827488) Katona G. … Szilagyi L. (J. Mol. Biol. 2002) 3 4 22 64
  5. Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. (PMID: 8294000) Wiegand U. … Mueller-Hill B. (Gene 1993) 2 3 4 64

Products for PRSS3 Gene

Sources for PRSS3 Gene

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