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Aliases for PRSS27 Gene

Aliases for PRSS27 Gene

  • Protease, Serine 27 2 3 5
  • Pancreasin 2 3 4
  • Marapsin 2 3 4
  • MPN 3 4
  • Channel-Activating Protease 2 3
  • Serine Protease 27 3
  • EC 61
  • EC 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61
  • CAPH2 3

External Ids for PRSS27 Gene

Previous GeneCards Identifiers for PRSS27 Gene

  • GC16U990229
  • GC16M002704
  • GC16M002705
  • GC16M002733
  • GC16M002768

Summaries for PRSS27 Gene

Entrez Gene Summary for PRSS27 Gene

  • This gene is located within a large protease gene cluster on chromosome 16. It belongs to the group-1 subfamily of serine proteases. The encoded protein is a secreted tryptic serine protease and is expressed mainly in the pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for PRSS27 Gene

PRSS27 (Protease, Serine 27) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS22.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS27 Gene

Genomics for PRSS27 Gene

Regulatory Elements for PRSS27 Gene

Enhancers for PRSS27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F002689 1.4 FANTOM5 Ensembl ENCODE 13.2 +28.9 28915 4.4 DRAP1 SAP130 ARID4B DMAP1 ZIC2 KMT2B ZNF48 ZNF335 POLR2A NR2F6 KCTD5 PRSS27 SRRM2-AS1 SRRM2 PAQR4 KREMEN2 ABCA17P ABCA3 ENSG00000269937 GC16M002686
GH16F002750 0.8 ENCODE 12 -32.5 -32495 4.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TIGD7 CLUAP1 ZNF213-AS1 ELOB PRSS33 ENSG00000221719 PRSS41 ZNF205 PRSS27 NME3
GH16F002675 1.2 Ensembl ENCODE 12 +44.7 44678 1.0 SMARCA4 CREB3L1 PRSS27 ERVK13-1 SRRM2-AS1 ABCA17P ABCA3 LOC652276 ENSG00000261613 PIR59611
GH16F002672 0.2 ENCODE 12 +46.8 46779 2.8 PKNOX1 ARID4B SIN3A ZNF121 ELK1 FOS SP3 YY2 NFYC REST ENSG00000261613 ERVK13-1 ENSG00000200059 ENSG00000261240 ENSG00000269937 PRSS27 SRRM2-AS1 ABCA17P ABCA3 PIR59611
GH16F002669 0.9 Ensembl ENCODE 12 +50.4 50378 0.8 HDAC1 HDGF CTCF ATF1 SAP130 ARID4B ZNF2 RAD21 ZNF335 HIC1 ERVK13-1 PRSS27 TBC1D24 SRRM2-AS1 ABCA17P ABCA3 GC16P002847
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRSS27 on UCSC Golden Path with GeneCards custom track

Promoters for PRSS27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000147739 -622 1601 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 GLIS2 ZNF143 KLF7

Genomic Location for PRSS27 Gene

2,712,418 bp from pter
2,720,578 bp from pter
8,161 bases
Minus strand

Genomic View for PRSS27 Gene

Genes around PRSS27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS27 Gene

Proteins for PRSS27 Gene

  • Protein details for PRSS27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 27
    Protein Accession:

    Protein attributes for PRSS27 Gene

    290 amino acids
    Molecular mass:
    31940 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS27 Gene

Selected DME Specific Peptides for PRSS27 Gene


Post-translational modifications for PRSS27 Gene

Other Protein References for PRSS27 Gene

Antibody Products

  • R&D Systems Antibodies for PRSS27 (Marapsin/Pancreasin)

Domains & Families for PRSS27 Gene

Gene Families for PRSS27 Gene

Suggested Antigen Peptide Sequences for PRSS27 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS27: view

Function for PRSS27 Gene

Enzyme Numbers (IUBMB) for PRSS27 Gene

Gene Ontology (GO) - Molecular Function for PRSS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS27: view
genes like me logo Genes that share phenotypes with PRSS27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS27

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS27 Gene

Localization for PRSS27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS27 Gene


Subcellular locations from

Jensen Localization Image for PRSS27 Gene COMPARTMENTS Subcellular localization image for PRSS27 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PRSS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PRSS27: view

Pathways & Interactions for PRSS27 Gene

SuperPathways for PRSS27 Gene

No Data Available

Interacting Proteins for PRSS27 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000306390 Q9BQR3-PRS27_HUMAN for PRSS27 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PRSS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS27: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS27 Gene

Transcripts for PRSS27 Gene

Unigene Clusters for PRSS27 Gene

Protease, serine 27:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS27 Gene

No ASD Table

Relevant External Links for PRSS27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRSS27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS27 Gene

This gene is overexpressed in Esophagus - Mucosa (x28.2), Vagina (x8.3), and Cervix - Ectocervix (x5.8).

Protein differential expression in normal tissues from HIPED for PRSS27 Gene

This gene is overexpressed in Cervix (54.2) and Saliva (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS27 Gene

Protein tissue co-expression partners for PRSS27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRSS27 Gene:


SOURCE GeneReport for Unigene cluster for PRSS27 Gene:


mRNA Expression by UniProt/SwissProt for PRSS27 Gene:

Tissue specificity: Expressed predominantly in the pancreas.
genes like me logo Genes that share expression patterns with PRSS27: view

Primer Products

Orthologs for PRSS27 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS27 34 35
  • 98.85 (n)
(Canis familiaris)
Mammalia PRSS27 34 35
  • 85.27 (n)
(Bos Taurus)
Mammalia PRSS27 34 35
  • 84.63 (n)
(Mus musculus)
Mammalia Prss27 34 16 35
  • 81.87 (n)
(Rattus norvegicus)
Mammalia Prss27 34
  • 79.32 (n)
(Monodelphis domestica)
Mammalia PRSS27 35
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia PRSS27 35
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
-- 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495333 34
  • 53.04 (n)
(Danio rerio)
Actinopterygii LOC100001520 34
  • 50.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004569 34
  • 46.46 (n)
Species where no ortholog for PRSS27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS27 Gene

Gene Tree for PRSS27 (if available)
Gene Tree for PRSS27 (if available)

Paralogs for PRSS27 Gene Pseudogenes for PRSS27 Gene

genes like me logo Genes that share paralogs with PRSS27: view

Variants for PRSS27 Gene

Sequence variations from dbSNP and Humsavar for PRSS27 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111375664 -- 2,715,699(+) GGGGG(C/T)AGGGG intron-variant, upstream-variant-2KB
rs111495225 -- 2,713,161(+) TGGCG(C/T)GATCT intron-variant
rs111565886 -- 2,713,402(+) CCTGG(A/C)ATCTG intron-variant
rs111587450 -- 2,716,654(+) AGGGA(A/C)CTCAC intron-variant, upstream-variant-2KB
rs111636677 -- 2,719,196(+) CAGGG(A/G)CAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS27 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv2760067 CNV gain+loss 17122850
nsv471073 CNV loss 18288195
nsv833123 CNV gain+loss 17160897

Variation tolerance for PRSS27 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS27 Gene

Disorders for PRSS27 Gene

Relevant External Links for PRSS27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRSS27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS27 Gene

Publications for PRSS27 Gene

  1. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. (PMID: 12441343) Bhagwandin V.J. … Caughey G.H. (J. Biol. Chem. 2003) 3 4 22 64
  2. The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. (PMID: 18948266) Li W. … Kirchhofer D. (J. Biol. Chem. 2009) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. (PMID: 23447538) Raman K. … Caughey G.H. (J. Biol. Chem. 2013) 3 64

Products for PRSS27 Gene

Sources for PRSS27 Gene

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