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Aliases for PRSS27 Gene

Aliases for PRSS27 Gene

  • Protease, Serine 27 2 3 5
  • Pancreasin 2 3 4
  • Marapsin 2 3 4
  • MPN 3 4
  • Channel-Activating Protease 2 3
  • EC 3.4.21.43 63
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • CAPH2 3

External Ids for PRSS27 Gene

Previous GeneCards Identifiers for PRSS27 Gene

  • GC16U990229
  • GC16M002704
  • GC16M002705
  • GC16M002733
  • GC16M002768

Summaries for PRSS27 Gene

Entrez Gene Summary for PRSS27 Gene

  • This gene is located within a large protease gene cluster on chromosome 16. It belongs to the group-1 subfamily of serine proteases. The encoded protein is a secreted tryptic serine protease and is expressed mainly in the pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for PRSS27 Gene

PRSS27 (Protease, Serine 27) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS27 Gene

Genomics for PRSS27 Gene

Regulatory Elements for PRSS27 Gene

Enhancers for PRSS27 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS27 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS27 Gene

Chromosome:
16
Start:
2,712,418 bp from pter
End:
2,720,578 bp from pter
Size:
8,161 bases
Orientation:
Minus strand

Genomic View for PRSS27 Gene

Genes around PRSS27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS27 Gene

Proteins for PRSS27 Gene

  • Protein details for PRSS27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQR3-PRS27_HUMAN
    Recommended name:
    Serine protease 27
    Protein Accession:
    Q9BQR3

    Protein attributes for PRSS27 Gene

    Size:
    290 amino acids
    Molecular mass:
    31940 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS27 Gene

Proteomics data for PRSS27 Gene at MOPED

Selected DME Specific Peptides for PRSS27 Gene

Post-translational modifications for PRSS27 Gene

Other Protein References for PRSS27 Gene

Antibody Products

  • R&D Systems Antibodies for PRSS27 (Marapsin/Pancreasin)

Domains & Families for PRSS27 Gene

Gene Families for PRSS27 Gene

Suggested Antigen Peptide Sequences for PRSS27 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQR3

UniProtKB/Swiss-Prot:

PRS27_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS27: view

Function for PRSS27 Gene

Enzyme Numbers (IUBMB) for PRSS27 Gene

genes like me logo Genes that share phenotypes with PRSS27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS27

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS27 Gene

Localization for PRSS27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS27 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS27 Gene COMPARTMENTS Subcellular localization image for PRSS27 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PRSS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PRSS27: view

Pathways & Interactions for PRSS27 Gene

SuperPathways for PRSS27 Gene

No Data Available

Interacting Proteins for PRSS27 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000306390%0d%0a9606.ENSP00000358327%0d%0a
Selected Interacting proteins: ENSP00000306390 for PRSS27 Gene via STRING

Symbol External ID(s) Details
CASP7

Gene Ontology (GO) - Biological Process for PRSS27 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRSS27 Gene

Drugs & Compounds for PRSS27 Gene

No Compound Related Data Available

Transcripts for PRSS27 Gene

Unigene Clusters for PRSS27 Gene

Protease, serine 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS27 Gene

No ASD Table

Relevant External Links for PRSS27 Gene

GeneLoc Exon Structure for
PRSS27
ECgene alternative splicing isoforms for
PRSS27

Expression for PRSS27 Gene

mRNA expression in normal human tissues for PRSS27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS27 Gene

This gene is overexpressed in Esophagus - Mucosa (x28.2), Vagina (x8.3), and Cervix - Ectocervix (x5.8).

Protein differential expression in normal tissues from HIPED for PRSS27 Gene

This gene is overexpressed in Cervix (54.2) and Saliva (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS27 Gene



SOURCE GeneReport for Unigene cluster for PRSS27 Gene Hs.332878

mRNA Expression by UniProt/SwissProt for PRSS27 Gene

Q9BQR3-PRS27_HUMAN
Tissue specificity: Expressed predominantly in the pancreas.
genes like me logo Genes that share expression patterns with PRSS27: view

Protein tissue co-expression partners for PRSS27 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PRSS27 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS27 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRSS27 35
  • 84.63 (n)
  • 82.16 (a)
PRSS27 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS27 35
  • 85.27 (n)
  • 84.42 (a)
PRSS27 36
  • 36 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss27 35
  • 81.87 (n)
  • 78.83 (a)
Prss27 16
Prss27 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRSS27 35
  • 98.85 (n)
  • 98.28 (a)
PRSS27 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss27 35
  • 79.32 (n)
  • 77.74 (a)
oppossum
(Monodelphis domestica)
Mammalia PRSS27 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS27 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495333 35
  • 53.04 (n)
  • 48.7 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100001520 35
  • 50.07 (n)
  • 47.06 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004569 35
  • 46.46 (n)
  • 39 (a)
Species with no ortholog for PRSS27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS27 Gene

ENSEMBL:
Gene Tree for PRSS27 (if available)
TreeFam:
Gene Tree for PRSS27 (if available)

Paralogs for PRSS27 Gene

Pseudogenes.org Pseudogenes for PRSS27 Gene

genes like me logo Genes that share paralogs with PRSS27: view

Variants for PRSS27 Gene

Sequence variations from dbSNP and Humsavar for PRSS27 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4387602 -- 2,713,527(-) CTCCC(A/C/G/T)CCTTG splice-donor-variant
rs4494542 -- 2,718,701(+) GTCTA(C/T)CTTGG intron-variant
rs13333497 -- 2,713,891(+) CTTCA(A/C)CCCCT intron-variant
rs9925647 -- 2,716,969(+) GGAGC(C/T)GTCTC intron-variant
rs757167 -- 2,717,177(-) CCTGG(A/G)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS27 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2545n71 CNV Loss 21882294
nsv905139 CNV Loss 21882294
dgv2570n71 CNV Loss 21882294
nsv905152 CNV Loss 21882294
dgv793e1 CNV Complex 17122850
nsv833123 CNV Gain+Loss 17160897
nsv905158 CNV Loss 21882294
dgv2572n71 CNV Loss 21882294
nsv905161 CNV Loss 21882294
nsv905162 CNV Gain 21882294
nsv905164 CNV Loss 21882294
nsv471073 CNV Loss 18288195
nsv905165 CNV Loss 21882294

Variation tolerance for PRSS27 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS27 Gene

HapMap Linkage Disequilibrium report
PRSS27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS27 Gene

Disorders for PRSS27 Gene

Relevant External Links for PRSS27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS27

No disorders were found for PRSS27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS27 Gene

Publications for PRSS27 Gene

  1. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. (PMID: 12441343) Bhagwandin V.J. … Caughey G.H. (J. Biol. Chem. 2003) 3 4 23 67
  2. The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. (PMID: 18948266) Li W. … Kirchhofer D. (J. Biol. Chem. 2009) 3 23
  3. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. (PMID: 23447538) Raman K. … Caughey G.H. (J. Biol. Chem. 2013) 3
  4. ENaC proteolytic regulation by channel-activating protease 2. (PMID: 18852303) GarcA-a-Caballero A. … Stutts M.J. (J. Gen. Physiol. 2008) 23
  5. Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates. (PMID: 17947681) Trivedi N.N. … Caughey G.H. (J. Immunol. 2007) 23

Products for PRSS27 Gene

Sources for PRSS27 Gene

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