PRSS27 Gene
protein-coding GIFtS: 45
GCID: GC16M002768
|
|
protease, serine 27
| |
Aliases
for PRSS27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protease, Serine 271 2 | | EC 3.4.21.-3 | | MPN1 2 3 | | Marapsin3 | | CAPH21 2 | | Pancreasin3 | | Marapsin3 | | EC 3.4.218 | | Pancreasin3 | | EC 3.4.21.48 | | Channel-Activating Protease 22 | | EC 3.4.21.438 | | Serine Protease 272 | | |
Export aliases for PRSS27 gene to outside databasesPrevious GC identifers: GC16U990229 GC16M002704 GC16M002705 GC16M002733 |
Summaries
for PRSS27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRSS27:
Pancreasin is a pancreatic tryptic serine peptidase that cleaves peptides after an arginine residue.(supplied by OMIM,Sep 2003)
|
Genomic Views
for PRSS27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRSS27 gene promoter:
CREB deltaCREB NRSF form 1 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRSS27
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS27 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3PRSS27 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M002768: view genomic region
(about GC identifiers)
Start:
|
2,762,419 bp from pter |
End:
|
2,770,552 bp from pter |
Size:
|
8,134 bases |
Orientation:
|
minus strand |
|
Proteins
for PRSS27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRS27_HUMAN, Q9BQR3 (See
protein sequence)Recommended Name: Serine protease 27 precursor Size: 290 amino acids; 31940 Da
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for PRSS27: NX_Q9BQR3
Post-translational modifications:
N-glycosylated1
View neXtProt modification sites for NX_Q9BQR3
4/12 DME Specific Peptides for PRSS27 (Q9BQR3) (see all 12)
PRSS27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114154.1
ENSEMBL proteins: ENSP00000306390 ENSP00000455636 ENSP00000456886
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005886 | plasma membrane |
IEA | -- |
PRSS27 for ontologies About GeneDecksing
PRSS27 Antibody Products:
Assay Products for PRSS27: |
Protein
Domains /
Families
for PRSS27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRSS27 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BQR3ProtoNet protein and cluster: Q9BQR3 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: PRS27_HUMAN, Q9BQR3Similarity: Belongs to the peptidase S1 familySimilarity: Contains 1 peptidase S1 domain |
Function
for PRSS27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Numbers (IUBMB): EC 3.4.21.432 EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS27 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS27
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PRSS27 (NM_031948) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRSS27 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS27 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS27 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- |
PRSS27 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for PRSS27:
Animal Models:
1 MGI phenotypic allele  for Prss27 (no phenotypes)
PRSS27 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRSS27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRSS27
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
PRSS27 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRSS27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRSS27
Search CenterWatch for drugs/clinical trials and news about PRSS27 / PRS27
|
Transcripts
for PRSS27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRSS27 gene: NM_031948.3 Unigene Cluster for PRSS27: Protease, serine 27 Hs.332878 [show with all ESTs]Unigene Representative Sequence: AK1265105 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000302641 ENST00000543965(uc002cre.3) ENST00000565903(uc002crf.3 uc002crg.3)
ENST00000562249(uc010bst.1) ENST00000566492
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS27 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS27
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRSS27 (NM_031948) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRSS27 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS27 |
Additional cDNA sequence: AB056161.1 AJ306593.1 AK126510.1 AK310214.1 AY030095.1 AY359106.1 BC034294.2 BC036912.2 3 DOTS entries: DT.40223324 DT.95149810 DT.95203996 24/30 AceView cDNA sequences (see all 30): AK126510 BC036912 BM832898 AY030095 BC034294 AY359106 NM_031948 BX284078 AJ306593 AI272325 BF353799 BM854083 BM792755 BG679626 AB056161 AK055576 AA321681 BM670388 BM712096 BF909691 BI254797 AW170323 AA368960 AW084167
GeneLoc Exon Structure
|
Expression
for PRSS27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRSS27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PRSS27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRSS27
SOURCE GeneReport for Unigene cluster: Hs.332878
UniProtKB/Swiss-Prot: PRS27_HUMAN, Q9BQR3Tissue specificity: Expressed predominantly in the pancreas
SABiosciences Custom PCR Arrays for PRSS27
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS27
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PRSS27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS27 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS27 |
Orthologs
for PRSS27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PRSS27 gene from 3/18 species (see all 18) About this table
ENSEMBL Gene Tree for PRSS27 (if available)
TreeFam Gene Tree for PRSS27 (if available) |
Paralogs
for PRSS27 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRSS27 gene
- PRSS462 PRSS552 PRSS482 PRSS222 PRSS212 PRSS452 TPSG12 TPSD12
- PRSS382 TPSAB12 PRSS532 PRSS502 PRSS422 PRSS362 PRSS332 KLKB12
- PRSS82 F112 OVCH12
18/96 SIMAP similar genes for PRSS27 using alignment to 2 protein entries: PRS27_HUMAN (see all proteins)
(see all similar genes):PRSS22 PRSS21 TMPRSS9 serase-1B KLKB1 PRSS44
PRSS45 PRSS33 PRSS36 PRSS38 TPSB2 TPSAB1
F9 F9 p22 HPN ST14 TPSG1 factor IX F9
PRSS27 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PRSS27
PGOHUM00000250633
|
Genomic Variants
for PRSS27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRSS27 (2762419 - 2770552 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PRSS27
3 CNVs: 4919 3988 5329 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRSS27 |
|
Disorders
/ Diseases
for PRSS27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRSS27 for disorders About GeneDecksing
OMIM gene information: 608018
OMIM disorders: --
5  diseases for PRSS27: About MalaCardspeptic ulcer cholecystitis pancreatitis psoriasis
carcinoma
Export disorders for PRSS27 gene to outside databases
|
Publications
for PRSS27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRSS27 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with PRSS27) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. (PubMed id 12441343)1, 2, 9 Bhagwandin V.J....Caughey G.H. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. (PubMed id 18948266)1, 9 Li W....Kirchhofer D. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- ENaC proteolytic regulation by channel-activating protease 2. (PubMed id 18852303)9 Garcia-Caballero A....Stutts M.J. (2008)
- Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates. (PubMed id 17947681)9 Trivedi N.N....Caughey G.H. (2007)
- [Prospects for standardization of surgical procedures for carcinoma of the pancreas] (PubMed id 12774526)9 Wataru K. (2003)
|
External Searches for PRSS27 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRSS27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRSS27 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRSS27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PRSS27 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PRSS27 gene:
Search GeneIP for patents involving PRSS27
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRSS27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PRSS27 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRSS27 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS27 | | | OriGene Protein Over-expression Lysate for PRSS27 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRSS27 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS27 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS27 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PRSS27 | | OriGene Custom Protein Services for PRSS27 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRSS27 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRSS27 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS27 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS27 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for PRSS27 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | PRSS27 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS27 |
|  |  |  | | | | Search ThermoFisher Antibodies for PRSS27 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS27 |
|
|
|
|
