Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRSS27 Gene

protein-coding   GIFtS: 45
GCID: GC16M002768

Protease, Serine 27

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protease, Serine 271 2     EC 3.4.21.-3
MPN2 3     Marapsin3
CAPH22     Pancreasin3
Channel-Activating Protease 22     EC 3.4.218
marapsin2     EC 3.4.21.48
pancreasin2     EC 3.4.21.438
Serine Protease 272     

External Ids:    HGNC: 154751   Entrez Gene: 838862   Ensembl: ENSG000001723827   OMIM: 6080185   UniProtKB: Q9BQR33   

Export aliases for PRSS27 gene to outside databases

Previous GC identifers: GC16U990229 GC16M002704 GC16M002705 GC16M002733


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRSS27 Gene:
Pancreasin is a pancreatic tryptic serine peptidase that cleaves peptides after an arginine residue.(supplied by
OMIM, Sep 2003)

GeneCards Summary for PRSS27 Gene: 
PRSS27 (protease, serine 27) is a protein-coding gene. Diseases associated with PRSS27 include cholecystitis, and peptic ulcer. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS46.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRSS27 gene promoter:
         CREB   deltaCREB   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS27 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRSS27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PRSS27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS27 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002768:  view genomic region     (about GC identifiers)

Start:
2,762,419 bp from pter      End:
2,770,552 bp from pter
Size:
8,134 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRS27_HUMAN, Q9BQR3 (See protein sequence)
Recommended Name: Serine protease 27 precursor  
Size: 290 amino acids; 31940 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for PRSS27: NX_Q9BQR3

Explore proteomics data for PRSS27 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View neXtProt modification sites for NX_Q9BQR3

  • 4/12 DME Specific Peptides for PRSS27 (Q9BQR3) (see all 12)
     CWVTGWG  SGGPLVC  SWGEGCA  FCGGSLI 

    PRSS27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRSS27 Protein Expression
    REFSEQ proteins: NP_114154.1  
    ENSEMBL proteins: 
     ENSP00000306390   ENSP00000455636   ENSP00000456886  

    Human Recombinant Protein Products for PRSS27: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PRSS27 (Marapsin/Pancreasin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PRSS27
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PRSS27
    GenScript Custom Purified and Recombinant Proteins Services for PRSS27
    Novus Biologicals PRSS27 Protein
    Novus Biologicals PRSS27 Lysate
    Sino Biological Recombinant Protein for PRSS27
    Sino Biological Cell Lysate for PRSS27 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--

    PRSS27 for ontologies           About GeneDecksing



    PRSS27 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PRSS27 (Marapsin/Pancreasin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PRSS27
    GenScript Custom Superior Antibodies Services for PRSS27
    Novus Biologicals PRSS27 Antibodies
    Abcam antibodies for PRSS27
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for PRSS27
    LSBio Antibodies in human, mouse, rat for PRSS27 

    Assay Products for PRSS27: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRSS27
    R&D Systems ELISAs for PRSS27 (Marapsin/Pancreasin)
    GenScript Custom Assay Services for PRSS27
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q9BQR3

    ProtoNet protein and cluster: Q9BQR3

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRS27_HUMAN, Q9BQR3
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    PRSS27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Numbers (IUBMB): EC 3.4.21.432 EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    PRSS27 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PRSS27:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         1 MGI phenotypic allele for Prss27 (no phenotypes)

    PRSS27 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRSS27 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRSS27

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRSS27 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRSS27 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRSS27
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PRSS27:
    hsa-miR-4283
    SwitchGear 3'UTR luciferase reporter plasmidPRSS27 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRSS27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS27

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRSS27
    Sirion Biotech Customized adenovirus for overexpression of PRSS27

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PRSS27 (see all 6)
    OriGene ORF clones in mouse, rat for PRSS27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRSS27 (NM_031948)
    Sino Biological Human cDNA Clone for PRSS27
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS27
    Sirion Biotech Customized lentivirus for stable overexpression of PRSS27 
                         Customized lentivirus expression plasmids for stable overexpression of PRSS27 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRSS27
    Search LifeMap BioReagents cell lines for PRSS27
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS27


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRSS27

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    PRSS27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRSS27 (PRS27)

    Search CenterWatch for drugs/clinical trials and news about PRSS27 / PRS27

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRSS27 gene: 
    NM_031948.3  

    Unigene Cluster for PRSS27:

    Protease, serine 27
    Hs.332878  [show with all ESTs]
    Unigene Representative Sequence: AK126510
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302641 ENST00000543965(uc002cre.3) ENST00000565903(uc002crf.3 uc002crg.3)
    ENST00000562249(uc010bst.1) ENST00000566492
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRSS27
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PRSS27:
    hsa-miR-4283
    SwitchGear 3'UTR luciferase reporter plasmidPRSS27 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRSS27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS27
    Clone
    Products:
         
    OriGene clones in human, mouse for PRSS27 (see all 6)
    OriGene ORF clones in mouse, rat for PRSS27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRSS27 (NM_031948)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS27
    Sirion Biotech Customized lentivirus for stable overexpression of PRSS27 
                         Customized lentivirus expression plasmids for stable overexpression of PRSS27 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRSS27
    OriGene qSTAR qPCR primer pairs in human, mouse for PRSS27
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PRSS27
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS27
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS27

    Additional mRNA sequence: 

    AB056161.1 AJ306593.1 AK126510.1 AK310214.1 AY030095.1 AY359106.1 BC034294.2 BC036912.2 

    3 DOTS entries:

    DT.40223324  DT.95149810  DT.95203996 

    24/30 AceView cDNA sequences (see all 30):

    BC036912 BF353799 AJ306593 AI272325 BC034294 AY030095 BM832898 BX284078 
    AK126510 AY359106 NM_031948 BG679626 BM854083 AK055576 BM670388 BM712096 
    AB056161 AA321681 BM792755 BF909691 BI254797 AW170323 BF916269 AW084167 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRSS27 expression in normal human tissues (normalized intensities)      PRSS27 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRSS27 Expression
    About this image


    PRSS27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             heart muscle ; myocytes   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             oral mucosa ; squamous epithelial cells   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   

    See PRSS27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRSS27

    SOURCE GeneReport for Unigene cluster: Hs.332878

    UniProtKB/Swiss-Prot: PRS27_HUMAN, Q9BQR3
    Tissue specificity: Expressed predominantly in the pancreas

        SABiosciences Custom PCR Arrays for PRSS27
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRSS27
    OriGene qSTAR qPCR primer pairs in human, mouse for PRSS27
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PRSS27
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS27
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS27
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS27 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss271 , 5 protease, serine, 271, 5 80.85(n)1
    77.51(a)1
      17 (12.21 cM)5
    2131711  NM_175440.41  NP_780649.11 
     240381445 
    lizard
    (Anolis carolinensis)
    Reptilia --
    PRSS276
    (see all 5)
    protease, serine 27
    (see all 5)
    48(a)
    48(a)
    (see all 5)
    possible ortholog
    1 ↔ 1
    (see all 5)
    GL343287.1(1517504-1579414)
    GL343287.1(1697243-1701085)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX854139.12   -- 72.56(n)    BX854139.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:923136
    BX571714.16
    (see all 17)
    Uncharacterized protein
    (see all 17)
    36(a)
    35(a)
    (see all 17)
    many ↔ many
    many ↔ many
    (see all 17)
    12(4921971-4929515)
    3(32827104-32832213)


    ENSEMBL Gene Tree for PRSS27 (if available)
    TreeFam Gene Tree for PRSS27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRSS27 gene
    PRSS462  PRSS482  PRSS222  TMPRSS92  PRSS212  PRSS452  TPSG12  TPSD12  
    PRSS382  TPSAB12  PRSS532  PRSS502  PRSS422  PRSS362  PRSS332  PRSS82  
    TPSB22  
    18/89 SIMAP similar genes for PRSS27 using alignment to 2 protein entries:     PRS27_HUMAN (see all proteins) (see all similar genes):
    PRSS22    PRSS21    TMPRSS9    serase-1B    KLKB1    PRSS44
    PRSS45    PRSS33    PRSS36    PRSS38    TPSB2    TPSAB1
    F9    F9 p22    ST14    TPSG1    factor IX F9    tryptaseC

    PRSS27 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PRSS27
    PGOHUM00000250633


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/279 SNPs in PRSS27 are shown (see all 279)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790494471,2
    C,F--2761925(+) TCAAGG/AGGAGA 1 -- ds50013Minor allele frequency- A:0.09CSA WA 122
    rs759453571,2
    C,F--2761932(+) GAGACG/TCCGGG 1 -- ds50013Minor allele frequency- T:0.09CSA WA 122
    rs727687511,2
    C,F--2761994(+) TGGGCA/GCCCAC 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1449454351,2
    --2762204(+) AAGGTA/GAGAGA 1 -- ds50010--------
    rs1154177781,2
    F--2762206(+) GGTGAG/AAGAAC 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1901689281,2
    --2762229(+) GGCAGC/GAGGTG 1 -- ds50010--------
    rs797322171,2
    C,F--2762269(+) CCCATA/GCTCTG 1 -- ds50013Minor allele frequency- G:0.13CSA WA 121
    rs1930633631,2
    --2762290(+) CGCCTC/TGGGCA 1 -- ds50010--------
    rs1145714001,2
    F--2762355(+) CCACCT/CGGGCT 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1856870321,2
    --2762424(+) CAGCTC/GGCACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PRSS27 (2762419 - 2770552 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for PRSS27 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2545n71CNV Loss21882294
    dgv2572n71CNV Loss21882294
    nsv905165CNV Loss21882294
    nsv905152CNV Loss21882294
    nsv905158CNV Loss21882294
    nsv905139CNV Loss21882294
    nsv471073CNV Loss18288195
    nsv905164CNV Loss21882294
    nsv905161CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PRSS27
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608018    OMIM disorders: --

    4 diseases for PRSS27:    About MalaCards
    cholecystitis    peptic ulcer    pancreatitis    psoriasis


    PRSS27 for disorders           About GeneDecksing


    Export disorders for PRSS27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRSS27 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with PRSS27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. (PubMed id 12441343)1, 2, 9 Bhagwandin V.J....Caughey G.H. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. (PubMed id 18948266)1, 9 Li W....Kirchhofer D. (2009)
    5. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchor s. (PubMed id 23447538)1 Raman K....Caughey G.H. (2013)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    9. ENaC proteolytic regulation by channel-activating protease 2. (PubMed id 18852303)9 Garcia-Caballero A....Stutts M.J. (2008)
    10. Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates. (PubMed id 17947681)9 Trivedi N.N....Caughey G.H. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83886 HGNC: 15475 AceView: MPN Ensembl:ENSG00000172382 euGenes: HUgn83886
    ECgene: PRSS27 H-InvDB: PRSS27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRSS27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRSS27 gene:
    Search GeneIP for patents involving PRSS27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PRSS27 (Marapsin/Pancreasin)   Browse Cell Culture Products  
     ELISAs for PRSS27 (Marapsin/Pancreasin)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for PRSS27 (Marapsin/Pancreasin)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PRSS27  
     OriGene qPCR primer pairs and template standards for PRSS27   OriGene Protein Over-expression Lysate for PRSS27  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PRSS27  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRSS27   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PRSS27   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRSS27   OriGene Custom Protein Services for PRSS27  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRSS27
     QIAGEN SeqTarget long-range PCR primers for resequencing PRSS27
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS27
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS27
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS27
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS27
     GenScript Custom Purified and Recombinant Proteins Services for PRSS27 GenScript cDNA clones with any tag delivered in your preferred vector for PRSS27
     GenScript Custom Assay Services for PRSS27 GenScript Custom Superior Antibodies Services for PRSS27
     GenScript Custom overexpressing Cell Line Services for PRSS27 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PRSS27 promoter
     Search Chromatin IP Primers for PRSS27
     RT2 qPCR Primer Assay in human, mouse / rat PRSS27
     Search GNC Networks for PRSS27
     SABiosciences Custom PCR Arrays for PRSS27
     Search Tocris compounds for PRSS27 (PRS27)
     Proteins and Antibodies for PRSS27
     Cell Lysates for PRSS27
     cDNA Clones for PRSS27
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRSS27 antibodies
     PRSS27 proteins
     PRSS27 lysates
     Antibodies for PRSS27
     See all of Abcam's Antibodies, Kits and Proteins for PRSS27
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PRSS27
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS27
     SwitchGear 3'UTR luciferase reporter plasmids for PRSS27
     SwitchGear Promoter luciferase reporter plasmids for PRSS27
     Search ThermoFisher Antibodies for PRSS27
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS27
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PRSS27
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRSS27
    Customized:
     lentivirus for stable overexpression of PRSS27
     lentivirus expression plasmids for stable overexpression of PRSS27
     adenovirus for overexpression of PRSS27
     LSBio Antibodies in human, mouse, rat for PRSS27
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRSS27 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4