Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRSS23 Gene

protein-coding   GIFtS: 50
GCID: GC11P086511

protease, serine, 23
 Explore 5 diseases affiliated with
PRSS23 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRSS23    

Aliases
for PRSS23 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protease, Serine, 231 2     Serine Protease 232
SIG131 2     Serine Protease, Umbilical Endothelium2
SPUVE1 2     EC 3.4.21.-3
Putative Secreted Protein Zsig132 3     EC 3.4.218
ZSIG132 3     EC 3.4.21.48

External Ids:    HGNC: 143701   Entrez Gene: 110982   Ensembl: ENSG000001506877   UniProtKB: O950843   

Export aliases for PRSS23 gene to outside databases

Previous GC identifer: GC11P086189


Summaries
for PRSS23 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRSS23:
This gene encodes a member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels
after ovulation was induced. This gene seems to be highly conserved in vertebrates and may be an important ovarian
protease. (provided by RefSeq, Jul 2008)

Gene Wiki entry for PRSS23


Genomic Views
for PRSS23 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRSS23 gene promoter:
         GR   STAT1   GR-beta   STAT1beta   STAT1alpha   YY1   FOXL1   Evi-1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRSS23 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRSS23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2

PRSS23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS23 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P086511:  view genomic region     (about GC identifiers)

Start:
 86,502,101 bp from pter      End:
 86,663,886 bp from pter
Size:
 161,786 bases      Orientation:
 plus strand

Proteins
for PRSS23 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PRS23_HUMAN, O95084 (See protein sequence)
Recommended Name: Serine protease 23 precursor  
Size: 383 amino acids; 43001 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B2RDJ1 Q6IBI0

Explore the universe of human proteins at neXtProt for PRSS23: NX_O95084

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95084

    • 4/7 DME Specific Peptides for PRSS23 (O95084) (see all 7)
     SGSGVYV  VLTAAHC  DYDYALLEL  SRRKRQIYGYD 

    PRSS23 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009104.1  
    ENSEMBL proteins: 
     ENSP00000435951   ENSP00000280258   ENSP00000436676   ENSP00000437268   ENSP00000393015  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for PRSS23 
    GenScript Custom Purified and Recombinant Proteins Services for PRSS23
    Novus Biologicals PRSS23 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PRSS23

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IDA--


    PRSS23 for ontologies           About GeneDecksing



    PRSS23 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PRSS23 
    GenScript Custom Superior Antibodies Services for PRSS23
    Novus Biologicals PRSS23 Antibodies
    Search for Antibodies for PRSS23 at Abcam  
    Uscn Antibodies for PRSS23
    Search ThermoFisher Antibodies for PRSS23

    Assay Products for PRSS23: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRSS23
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PRSS23

    Protein Domains /
    Families
    for PRSS23 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRSS23 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry O95084

    ProtoNet protein and cluster: O95084

    2 Blocks protein families:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRS23_HUMAN, O95084
    Similarity: Belongs to the peptidase S1 family


    Function
    for PRSS23 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PRSS23
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRSS23
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PRSS23 (see all 21):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-576-3p hsa-miR-875-3p hsa-miR-607 hsa-miR-330-5p hsa-miR-548l hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmid: PRSS23 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRSS23 (see all 7)
    OriGene shRNA RFP: PRSS23
    OriGene siRNA: PRSS23
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS23

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRSS23

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS23 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS23 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PRSS23 (NM_007173)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS23 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PRSS23
    Search LifeMap BioReagents cell lines for PRSS23

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS23

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--


    PRSS23 for ontologies           About GeneDecksing



    Pathways & Interactions
    for PRSS23 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRSS23

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/39 Interacting proteins for PRSS23 (O950842, 3 ENSP000002802584) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHP1Q996532, 3MINT-63258 I2D: score=5 
    EFNA3P527972, 3MINT-63247 I2D: score=5 
    FXR1P511142, 3MINT-63255 I2D: score=5 
    GRK6P432502, 3MINT-63246 I2D: score=5 
    MAPK8IP2Q133872, 3MINT-63250 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    PRSS23 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRSS23 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRSS23
    Search CenterWatch for drugs/clinical trials and news about PRSS23 / PRS23 

    Transcripts
    for PRSS23 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRSS23 gene: 
    NM_007173.4  

    Unigene Cluster for PRSS23:

    Protease, serine, 23
    Hs.25338  [show with all ESTs]
    Unigene Representative Sequence: NM_007173
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527521 ENST00000280258(uc010rts.1 uc001pcb.3) ENST00000532234(uc001pcc.1)
    ENST00000533902 ENST00000531475 ENST00000533880 ENST00000532572(uc001pcd.3)
    ENST00000528769 ENST00000531521 ENST00000441050

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PRSS23
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRSS23
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PRSS23 (see all 21):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-576-3p hsa-miR-875-3p hsa-miR-607 hsa-miR-330-5p hsa-miR-548l hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmid: PRSS23 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRSS23 (see all 7)
    OriGene shRNA RFP: PRSS23
    OriGene siRNA: PRSS23
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS23
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS23 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS23 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PRSS23 (NM_007173)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS23 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS23
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRSS23
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS23
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS23

    Additional cDNA sequence: 

    AF015287.1 AF193611.1 AK075362.1 AK304054.1 AK304301.1 AK315562.1 AK316508.1 AL136914.1 
    AY359033.1 BC001278.1 BC063022.1 CR456824.1 

    21 DOTS entries:

    DT.215865  DT.99936778  DT.95259185  DT.100030211  DT.95169263  DT.95169266  DT.99958064  DT.101973708 
    DT.217067  DT.95125042  DT.100715832  DT.100816993  DT.120735278  DT.120735288  DT.120735347  DT.92446656 
    DT.95116364  DT.95118891  DT.95150776  DT.97807838  DT.97847183 

    24/470 AceView cDNA sequences (see all 470):

    CR622497 BQ219719 CR613177 BE327874 CR624329 BQ029812 CA419986 BQ772801 
    BQ573866 AI094190 BU686022 CA422611 BQ773770 AI628017 AL703384 BQ688896 
    AK075362 AI371263 BE876666 BU633311 BP353733 BE906942 BQ225242 BQ219153 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS23    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for PRSS23

    Expression
    for PRSS23 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRSS23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRSS23 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordOvarian Somatic CellsOvary
    CartilageLumbar Intervertebral DiscCartilage
    KidneyMetanephrosKidney
    KidneyRenal VesicleKidney
    KidneyS-shaped BodyKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (Generation of mesend...)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    CD31, CD144 positive cells (Two-step protocol fo...)

    See PRSS23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRSS23

    SOURCE GeneReport for Unigene cluster: Hs.25338
        SABiosciences Custom PCR Arrays for PRSS23
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS23
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRSS23
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS23
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS23
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS23

    Orthologs
    for PRSS23 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS23 gene from 3/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRSS231 protease, serine, 23 77.51(n)
    86.72(a)    		   419017  XM_417210.2  XP_417210.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PRSS236
    		 --
    		 82(a)
    		 1 ↔ 1
    		 3(200137893-200139008)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb01h122 Transcribed sequence with weak similarity to protein more 75.9(n)    57090351 


    ENSEMBL Gene Tree for PRSS23 (if available)
    TreeFam Gene Tree for PRSS23 (if available) 

    Paralogs
    for PRSS23 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRSS23 gene
    PRSS352  
    1 SIMAP similar gene for PRSS23 using alignment to 5 protein entries:     PRS23_HUMAN (see all proteins):
    PRSS35

    PRSS23 for paralogs           About GeneDecksing



    Genomic Variants
    for PRSS23 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/250 NCBI SNPs in PRSS23 are shown (see all 250)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs735207061,2
    		C,--86509497(+) GGAACG/AAAGGA 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1114522011,2
    		--86509522(+) TTGAGA/TCTGCA 1 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1395655321,2
    		--86509528(+) CTGCAA/TTGGGC 1 -- us2k10--------
    rs1498218631,2
    		--86509529(+) TGCATC/TGGGCA 1 -- us2k10--------
    rs1890550361,2
    		--86509697(+) TTTGCA/GAGTTG 1 -- us2k10--------
    rs1807955041,2
    		--86509788(+) TTGGAA/GTGCAG 1 -- us2k10--------
    rs1873874741,2
    		--86509794(+) TGCAGC/TGGTGA 1 -- us2k10--------
    rs1908817601,2
    		--86509829(+) TCCTGA/GGCTCA 1 -- us2k10--------
    rs1828968201,2
    		--86510150(+) AAATAC/GCAGGC 1 -- us2k10--------
    rs1857067831,2
    		--86510174(+) TCACGC/TGTGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRSS23 (86502101 - 86663886 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PRSS23: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRSS23
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS23

    Disorders / Diseases
    for PRSS23 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRSS23 for disorders           About GeneDecksing

    5 diseases for PRSS23:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    prostate cancer    obesity
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for PRSS23:
    Cleft lip
    Human Genome Epidemiology (HuGE) Navigator: PRSS23 (1 document)

    Export disorders for PRSS23 gene to outside databases

    Publications
    for PRSS23 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRSS23 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with PRSS23)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PubMed id 16870946)1, 9 Miyakoshi K....Hennebold J.D. (2006)
    5. Serine protease PRSS23 is upregulated by estrogen rece ptor a and associated with proliferation of breast cancer cells. (PubMed id 22291950)1 Chan H.S....Chuang Y.J. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Use of genome-wide expression data to mine the ' Gray Zone' of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1 Naukkarinen J....Peltonen L. (2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for PRSS23 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRSS23 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11098 HGNC: 14370 AceView: PRSS23 Ensembl:ENSG00000150687 euGenes: HUgn11098
    ECgene: PRSS23 H-InvDB: PRSS23

    Other Databases showing PRSS23 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRSS23 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRSS23 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PRSS23 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRSS23 gene:
    Search GeneIP for patents involving PRSS23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PRSS23 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PRSS23  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRSS23   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRSS23  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PRSS23   OriGene 3'-UTR Clone for PRSS23  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS23   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS23  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRSS23   OriGene Custom Protein Services for PRSS23  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRSS23
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRSS23
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS23
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS23
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS23
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS23
     GenScript Custom Purified and Recombinant Proteins Services for PRSS23 GenScript cDNA clones with any tag delivered in your preferred vector for PRSS23
     GenScript Custom Assay Services for PRSS23 GenScript Custom Superior Antibodies Services for PRSS23
     GenScript Custom overexpressing Cell Line Services for PRSS23 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PRSS23 promoter
     Search Chromatin IP Primers for PRSS23
     RT2 qPCR Primer Assay in human, mouse, rat PRSS23
     Search GNC Networks for PRSS23
     SABiosciences Custom PCR Arrays for PRSS23
     Search Tocris compounds for PRSS23
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRSS23 antibodies
     PRSS23 proteins
     Search for Antibodies for PRSS23 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PRSS23
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PRSS23 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PRSS23
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS23
     SwitchGear 3'UTR luciferase reporter plasmids for PRSS23
     SwitchGear Promoter luciferase reporter plasmids for PRSS23
     Search ThermoFisher Antibodies for PRSS23
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS23
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PRSS23 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4