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Aliases for PRSS23 Gene

Aliases for PRSS23 Gene

  • Protease, Serine 23 2 3 5
  • Putative Secreted Protein Zsig13 3 4
  • ZSIG13 3 4
  • Serine Protease, Umbilical Endothelium 3
  • Protease, Serine, 23 3
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • SIG13 3
  • SPUVE 3

External Ids for PRSS23 Gene

Previous GeneCards Identifiers for PRSS23 Gene

  • GC11P086189
  • GC11P086511

Summaries for PRSS23 Gene

Entrez Gene Summary for PRSS23 Gene

  • This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for PRSS23 Gene

PRSS23 (Protease, Serine 23) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS35.

Gene Wiki entry for PRSS23 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS23 Gene

Genomics for PRSS23 Gene

Regulatory Elements for PRSS23 Gene

Genomic Location for PRSS23 Gene

Chromosome:
11
Start:
86,791,059 bp from pter
End:
86,952,910 bp from pter
Size:
161,852 bases
Orientation:
Plus strand

Genomic View for PRSS23 Gene

Genes around PRSS23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS23 Gene

Proteins for PRSS23 Gene

  • Protein details for PRSS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95084-PRS23_HUMAN
    Recommended name:
    Serine protease 23
    Protein Accession:
    O95084
    Secondary Accessions:
    • B2RDJ1
    • B4E2J3
    • Q6IBI0

    Protein attributes for PRSS23 Gene

    Size:
    383 amino acids
    Molecular mass:
    43001 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS23 Gene

Proteomics data for PRSS23 Gene at MOPED

Post-translational modifications for PRSS23 Gene

  • Ubiquitination at Lys 50
  • Glycosylation at Thr 73, Asn 93, and Asn 207
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS23 Gene

Antibody Products

Domains & Families for PRSS23 Gene

Gene Families for PRSS23 Gene

Suggested Antigen Peptide Sequences for PRSS23 Gene

Graphical View of Domain Structure for InterPro Entry

O95084

UniProtKB/Swiss-Prot:

PRS23_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS23: view

Function for PRSS23 Gene

Enzyme Numbers (IUBMB) for PRSS23 Gene

genes like me logo Genes that share phenotypes with PRSS23: view

Animal Model Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS23 Gene

Localization for PRSS23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS23 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS23 Gene COMPARTMENTS Subcellular localization image for PRSS23 gene
Compartment Confidence
extracellular 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for PRSS23 Gene

Pathways & Interactions for PRSS23 Gene

SuperPathways for PRSS23 Gene

No Data Available

Interacting Proteins for PRSS23 Gene

Gene Ontology (GO) - Biological Process for PRSS23 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRSS23 Gene

Drugs & Compounds for PRSS23 Gene

No Compound Related Data Available

Transcripts for PRSS23 Gene

Unigene Clusters for PRSS23 Gene

Protease, serine, 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS23 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for PRSS23 Gene

GeneLoc Exon Structure for
PRSS23
ECgene alternative splicing isoforms for
PRSS23

Expression for PRSS23 Gene

mRNA expression in normal human tissues for PRSS23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRSS23 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (47.7) and Amniocyte (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRSS23 Gene



SOURCE GeneReport for Unigene cluster for PRSS23 Gene Hs.25338

genes like me logo Genes that share expression patterns with PRSS23: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PRSS23 Gene

Orthologs for PRSS23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRSS23 35
  • 87.73 (n)
  • 93.6 (a)
PRSS23 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS23 35
  • 88.54 (n)
  • 94.18 (a)
PRSS23 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss23 35
  • 86.21 (n)
  • 90.84 (a)
Prss23 16
Prss23 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRSS23 35
  • 99.56 (n)
  • 99.74 (a)
PRSS23 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss23 35
  • 85.47 (n)
  • 91.38 (a)
oppossum
(Monodelphis domestica)
Mammalia PRSS23 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS23 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRSS23 35
  • 78.21 (n)
  • 87.53 (a)
PRSS23 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRSS23 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prss23 35
  • 70.9 (n)
  • 79.66 (a)
zebrafish
(Danio rerio)
Actinopterygii wufb01h12 35
PRSS23 36
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8589 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for PRSS23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS23 Gene

ENSEMBL:
Gene Tree for PRSS23 (if available)
TreeFam:
Gene Tree for PRSS23 (if available)

Paralogs for PRSS23 Gene

Paralogs for PRSS23 Gene

(1) SIMAP similar genes for PRSS23 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PRSS23: view

Variants for PRSS23 Gene

Sequence variations from dbSNP and Humsavar for PRSS23 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs750789 -- 86,791,250(+) CAGCA(C/T)AGCCC intron-variant
rs868871 -- 86,908,726(-) TTCAC(A/G)TCTGA intron-variant
rs754490 -- 86,792,065(-) GCACA(C/T)TGGGA intron-variant
rs872619 -- 86,799,298(-) TTTTA(A/C)ATGAG intron-variant, upstream-variant-2KB
rs921871 -- 86,938,060(-) TGGGG(C/T)AACTA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PRSS23 Gene

Variant ID Type Subtype PubMed ID
nsv521505 CNV Gain 19592680
nsv523704 CNV Loss 19592680

Variation tolerance for PRSS23 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS23 Gene

HapMap Linkage Disequilibrium report
PRSS23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS23 Gene

Disorders for PRSS23 Gene

Relevant External Links for PRSS23

Genetic Association Database (GAD)
PRSS23
Human Genome Epidemiology (HuGE) Navigator
PRSS23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS23

No disorders were found for PRSS23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS23 Gene

Publications for PRSS23 Gene

  1. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 48 67
  2. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PMID: 16870946) Miyakoshi K. … Hennebold J.D. (Biol. Reprod. 2006) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. (PMID: 23353556) LeBleu V.S. … Kalluri R. (Nat. Med. 2013) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for PRSS23 Gene

Sources for PRSS23 Gene

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