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Aliases for PRSS23 Gene

Aliases for PRSS23 Gene

  • Protease, Serine 23 2 3 5
  • Putative Secreted Protein Zsig13 3 4
  • ZSIG13 3 4
  • Serine Protease, Umbilical Endothelium 3
  • Serine Protease 23 3
  • EC 58
  • EC 3.4.21.- 4
  • EC 3.4.21 58
  • SIG13 3
  • SPUVE 3

External Ids for PRSS23 Gene

Previous GeneCards Identifiers for PRSS23 Gene

  • GC11P086189
  • GC11P086511

Summaries for PRSS23 Gene

Entrez Gene Summary for PRSS23 Gene

  • This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for PRSS23 Gene

PRSS23 (Protease, Serine 23) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS35.

Gene Wiki entry for PRSS23 Gene

Additional gene information for PRSS23 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS23 Gene

Genomics for PRSS23 Gene

Regulatory Elements for PRSS23 Gene

Enhancers for PRSS23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H086734 2 FANTOM5 Ensembl ENCODE dbSUPER 19 -49.1 -49050 14.2 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF766 CBX5 ZNF143 FOS PRSS23 EED LOC100289518 LOC100420680 ME3 LOC102724775
GH11H086576 1.4 Ensembl ENCODE dbSUPER 16.4 -213.2 -213167 3.6 PKNOX1 FEZF1 TSHZ1 ZNF488 ZNF623 ZNF610 GLIS1 MYNN KDM1A WT1 PRSS23 ME3 PIR51426 PIR57473 GC11P086542
GH11H086522 1.5 Ensembl ENCODE dbSUPER 9.9 -266.8 -266767 3 FOXA2 FEZF1 BRCA1 YY1 TCF12 ATF7 FOS DEK SP3 TSHZ1 PRSS23 CCDC81 PIR41176 PIR44417
GH11H086513 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.6 -274.0 -273954 7.5 HDAC1 PKNOX1 TBL1XR1 ARNT INSM2 FEZF1 TCF12 GATA2 EGR1 ZSCAN5C PRSS23 HIKESHI CCDC81 ME3 LOC100289518 PIR44417 PIR41176
GH11H086798 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.8 +12.3 12276 9.3 TBP KLF17 SIN3A BMI1 BATF RAD21 RFX5 GLIS2 SCRT2 FOS ME3 PRSS23 LOC102724775 LOC100131078
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRSS23 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS23 Gene

Genomic Locations for PRSS23 Gene
161,852 bases
Plus strand

Genomic View for PRSS23 Gene

Genes around PRSS23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS23 Gene

Proteins for PRSS23 Gene

  • Protein details for PRSS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 23
    Protein Accession:
    Secondary Accessions:
    • B2RDJ1
    • B4E2J3
    • Q6IBI0

    Protein attributes for PRSS23 Gene

    383 amino acids
    Molecular mass:
    43001 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS23 Gene


neXtProt entry for PRSS23 Gene

Selected DME Specific Peptides for PRSS23 Gene


Post-translational modifications for PRSS23 Gene

  • Ubiquitination at isoforms=50
  • Glycosylation at Thr73, isoforms=293, and Asn207
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS23 Gene

Domains & Families for PRSS23 Gene

Gene Families for PRSS23 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS23 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS23: view

Function for PRSS23 Gene

Enzyme Numbers (IUBMB) for PRSS23 Gene

Phenotypes From GWAS Catalog for PRSS23 Gene

Gene Ontology (GO) - Molecular Function for PRSS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS23: view
genes like me logo Genes that share phenotypes with PRSS23: view

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS23 Gene

Localization for PRSS23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS23 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS23 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for PRSS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IDA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with PRSS23: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS23 Gene

Pathways & Interactions for PRSS23 Gene

SuperPathways for PRSS23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PRSS23: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS23 Gene

Drugs & Compounds for PRSS23 Gene

No Compound Related Data Available

Transcripts for PRSS23 Gene

Unigene Clusters for PRSS23 Gene

Protease, serine, 23:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS23 Gene

ExUns: 1a · 1b ^ 2a · 2b

Relevant External Links for PRSS23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRSS23 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (47.7) and Amniocyte (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRSS23 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS23 Gene:


SOURCE GeneReport for Unigene cluster for PRSS23 Gene:


Evidence on tissue expression from TISSUES for PRSS23 Gene

  • Nervous system(3.9)
  • Lung(3.2)
  • Pancreas(2.6)
  • Intestine(2.5)
genes like me logo Genes that share expression patterns with PRSS23: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS23 Gene

Orthologs for PRSS23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS23 33 34
  • 99.56 (n)
(Canis familiaris)
Mammalia PRSS23 33 34
  • 88.54 (n)
(Bos Taurus)
Mammalia PRSS23 33 34
  • 87.73 (n)
(Mus musculus)
Mammalia Prss23 33 16 34
  • 86.21 (n)
(Monodelphis domestica)
Mammalia PRSS23 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Prss23 33
  • 85.47 (n)
(Ornithorhynchus anatinus)
Mammalia PRSS23 34
  • 82 (a)
(Gallus gallus)
Aves PRSS23 33 34
  • 78.21 (n)
(Anolis carolinensis)
Reptilia PRSS23 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prss23 33
  • 70.9 (n)
(Danio rerio)
Actinopterygii PRSS23 34
  • 49 (a)
wufb01h12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8589 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for PRSS23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS23 Gene

Gene Tree for PRSS23 (if available)
Gene Tree for PRSS23 (if available)

Paralogs for PRSS23 Gene

Paralogs for PRSS23 Gene

(1) SIMAP similar genes for PRSS23 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PRSS23: view

Variants for PRSS23 Gene

Sequence variations from dbSNP and Humsavar for PRSS23 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs104894223 Pathogenic 86,951,990(-) CCATC(A/G)TATTT nc-transcript-variant, reference, missense
rs80358284 Pathogenic 86,952,443(-) TGCCA(A/G/T)TGTGC nc-transcript-variant, reference, missense
rs80358292 Pathogenic 86,951,751(-) AAATG(C/G)GGTCA nc-transcript-variant, reference, missense
rs80358293 Pathogenic 86,951,732(-) TTGAA(A/G)TGCAC nc-transcript-variant, reference, missense
rs80358294 Pathogenic 86,951,506(-) AATTC(A/C/G)GTCAA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PRSS23 Gene

Variant ID Type Subtype PubMed ID
nsv975959 CNV duplication 23825009
nsv524804 CNV loss 19592680
nsv523704 CNV loss 19592680
nsv521505 CNV gain 19592680
nsv428263 CNV loss 18775914
nsv1144582 CNV deletion 24896259
nsv1143549 CNV deletion 24896259
nsv1076378 CNV duplication 25765185
nsv1049157 CNV gain 25217958
esv988093 CNV gain 20482838
esv3627110 CNV loss 21293372
esv3627109 CNV loss 21293372
esv3627108 CNV loss 21293372
esv3627107 CNV loss 21293372
esv3627106 CNV loss 21293372
esv3627105 CNV loss 21293372
esv3627099 CNV gain 21293372
esv3579789 CNV loss 25503493
esv3548100 CNV deletion 23714750
esv3334201 CNV insertion 20981092
esv2760199 CNV loss 21179565
esv2744858 CNV deletion 23290073
esv2744857 CNV deletion 23290073
esv27019 CNV loss 19812545
esv2666085 CNV deletion 23128226
esv2658766 CNV deletion 23128226

Variation tolerance for PRSS23 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS23 Gene

Disorders for PRSS23 Gene

Relevant External Links for PRSS23

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRSS23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS23 Gene

Publications for PRSS23 Gene

  1. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 45 60
  2. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PMID: 16870946) Miyakoshi K … Hennebold JD (Biology of reproduction 2006) 3 22 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60

Products for PRSS23 Gene

Sources for PRSS23 Gene

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