Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PRSS23 Gene

protein-coding   GIFtS: 53
GCID: GC11P086511

Protease, Serine, 23

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protease, Serine, 231 2     Serine Protease 232
Putative Secreted Protein Zsig132 3     Serine Protease, Umbilical Endothelium2
ZSIG132 3     EC 3.4.21.-3
SIG132     EC 3.4.218
SPUVE2     EC 3.4.21.48

External Ids:    HGNC: 143701   Entrez Gene: 110982   Ensembl: ENSG000001506877   UniProtKB: O950843   

Export aliases for PRSS23 gene to outside databases

Previous GC identifer: GC11P086189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PRSS23 Gene:
This gene encodes a member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA
levels after ovulation was induced. This gene seems to be highly conserved in vertebrates and may be an important
ovarian protease. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRSS23 Gene:
PRSS23 (protease, serine, 23) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS35.

Gene Wiki entry for PRSS23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRSS23 gene promoter:
         GR   STAT1   GR-beta   STAT1beta   STAT1alpha   YY1   FOXL1   Evi-1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS23 promoter sequence
   Search Chromatin IP Primers for PRSS23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2

PRSS23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS23 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P086511:  view genomic region     (about GC identifiers)

Start:
86,502,101 bp from pter      End:
86,663,952 bp from pter
Size:
161,852 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PRS23_HUMAN, O95084 (See protein sequence)
Recommended Name: Serine protease 23 precursor  
Size: 383 amino acids; 43001 Da
Secondary accessions: B2RDJ1 Q6IBI0

Explore the universe of human proteins at neXtProt for PRSS23: NX_O95084

Explore proteomics data for PRSS23 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys50
  • Glycosylation2 at Thr73, Asn93, Asn207
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRSS23 (O95084) (see all 7)
     SGSGVYV  VLTAAHC  DYDYALLEL  SRRKRQIYGYD 


    See PRSS23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009104.1  
    ENSEMBL proteins: 
     ENSP00000435951   ENSP00000280258   ENSP00000436676   ENSP00000437268   ENSP00000393015  

    PRSS23 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PRSS23
    GenScript Custom Purified and Recombinant Proteins Services for PRSS23
    Novus Biologicals PRSS23 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRSS23

     
    Search eBioscience for Proteins for PRSS23 

     
    antibodies-online proteins for PRSS23 (5 products) 

     
    antibodies-online peptides for PRSS23

    PRSS23 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PRSS23
    Novus Biologicals PRSS23 Antibodies
    Abcam antibodies for PRSS23
    Cloud-Clone Corp. Antibodies for PRSS23
    Search ThermoFisher Antibodies for PRSS23
    antibodies-online antibodies for PRSS23 (3 products) 

    PRSS23 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRSS23
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRSS23
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRSS23
    Cloud-Clone Corp. CLIAs for PRSS23
    Search eBioscience for ELISAs for PRSS23 
    antibodies-online kits for PRSS23 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    3 InterPro protein domains:
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry O95084

    ProtoNet protein and cluster: O95084

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRS23_HUMAN, O95084
    Similarity: Belongs to the peptidase S1 family


    Find genes that share domains with PRSS23           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    Find genes that share ontologies with PRSS23           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PRSS23

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRSS23:
    hsa-mir-192-5p (MIRT026709), hsa-mir-215-5p (MIRT024605)

    Block miRNA regulation of human, mouse, rat PRSS23 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRSS23 (see all 21):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-576-3p hsa-miR-875-3p hsa-miR-607 hsa-miR-330-5p hsa-miR-548l hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidPRSS23 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRSS23
    Predesigned siRNA for gene silencing in human, mouse, rat PRSS23

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRSS23

    Clone
    Products:
         
    OriGene clones in human, mouse for PRSS23 (see all 7)
    OriGene ORF clones in mouse, rat for PRSS23
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRSS23 (NM_007173)
    Sino Biological Human cDNA Clone for PRSS23
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS23

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRSS23
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRSS23 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS23


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PRS23_HUMAN, O95084: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    extracellular3
    mitochondrion2
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005634nucleus IDA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with PRSS23           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS23
    Interactions:

        Search GeneGlobe Interaction Network for PRSS23

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for PRSS23 (O950842, 3 ENSP000002802584) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHP1Q996532, 3MINT-63258 I2D: score=5 
    EFNA3P527972, 3MINT-63247 I2D: score=5 
    FXR1P511142, 3MINT-63255 I2D: score=5 
    GRK6P432502, 3MINT-63246 I2D: score=5 
    MAPK8IP2Q133872, 3MINT-63250 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with PRSS23           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS23 (PRS23)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PRSS23 gene: 
    NM_007173.4  

    Unigene Cluster for PRSS23:

    Protease, serine, 23
    Hs.25338  [show with all ESTs]
    Unigene Representative Sequence: NM_007173
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527521 ENST00000280258(uc010rts.1 uc001pcb.3) ENST00000532234(uc001pcc.1)
    ENST00000533902 ENST00000531475 ENST00000533880 ENST00000532572(uc001pcd.3)
    ENST00000528769 ENST00000531521 ENST00000441050
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRSS23 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRSS23 (see all 21):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-576-3p hsa-miR-875-3p hsa-miR-607 hsa-miR-330-5p hsa-miR-548l hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidPRSS23 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRSS23
    Predesigned siRNA for gene silencing in human, mouse, rat PRSS23
    Clone
    Products:
         
    OriGene clones in human, mouse for PRSS23 (see all 7)
    OriGene ORF clones in mouse, rat for PRSS23
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRSS23 (NM_007173)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS23
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRSS23
    OriGene qSTAR qPCR primer pairs in human, mouse for PRSS23
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRSS23
      QuantiTect SYBR Green Assays in human, mouse, rat PRSS23
      QuantiFast Probe-based Assays in human, mouse, rat PRSS23

    Additional mRNA sequence: 

    AF015287.1 AF193611.1 AK075362.1 AK304054.1 AK304301.1 AK315562.1 AK316508.1 AL136914.1 
    AY359033.1 BC001278.1 BC063022.1 CR456824.1 

    21 DOTS entries:

    DT.215865  DT.99936778  DT.95259185  DT.100030211  DT.95169263  DT.95169266  DT.99958064  DT.101973708 
    DT.217067  DT.95125042  DT.100715832  DT.100816993  DT.120735278  DT.120735288  DT.120735347  DT.92446656 
    DT.95116364  DT.95118891  DT.95150776  DT.97807838  DT.97847183 

    Selected AceView cDNA sequences (see all 470):

    NM_007173 BM998890 AI081820 AA977524 CB306614 CR607039 CR609619 BM834368 
    AL602985 BU191884 BE673511 BM787644 AI245052 BQ232665 BM968474 BU629949 
    BU175457 CR594839 AI422820 BQ421142 BU615259 AI129364 CN481434 BM978834 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS23    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for PRSS23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PRSS23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRSS23 Expression
    About this image


    PRSS23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             Human umbilical vein endothelial cells (HUVEC)
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             Oligodendrocyte-like cells
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
    PRSS23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25338
        Custom PCR Arrays for PRSS23
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRSS23
    OriGene qSTAR qPCR primer pairs in human, mouse for PRSS23
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRSS23
    QuantiTect SYBR Green Assays in human, mouse, rat PRSS23
    QuantiFast Probe-based Assays in human, mouse, rat PRSS23
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS23 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss231 , 5 protease, serine, 235
    protease, serine 231
    86.21(n)1
    90.84(a)1
      7 (49.90 cM)5
    764531  NM_029614.31  NP_083890.21 
     895077855 
    chicken
    (Gallus gallus)
    Aves PRSS231 protease, serine, 23 78.21(n)
    87.53(a)
      419017  XM_001234470.2  XP_001234471.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRSS236
    protease, serine, 23
    79(a)
    1 ↔ 1
    3(200137893-200155798)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prss231 protease, serine, 23 70.9(n)
    79.66(a)
      100127808  NM_001113120.1  NP_001106591.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb01h122 Transcribed sequence with weak similarity to protein more 75.9(n)    57090351 


    ENSEMBL Gene Tree for PRSS23 (if available)
    TreeFam Gene Tree for PRSS23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PRSS23 gene
    PRSS352  
    1 SIMAP similar gene for PRSS23 using alignment to 5 protein entries:     PRS23_HUMAN (see all proteins):
    PRSS35

    Find genes that share paralogs with PRSS23           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PRSS23 (see all 300)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735207061,2
    C,F--86509497(+) GGAACG/AAAGGA 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1114522011,2
    F--86509522(+) TTGAGA/TCTGCA 1 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1395655321,2
    --86509528(+) CTGCAA/TTGGGC 1 -- us2k10--------
    rs1498218631,2
    --86509529(+) TGCATC/TGGGCA 1 -- us2k10--------
    rs1890550361,2
    --86509697(+) TTTGCA/GAGTTG 1 -- us2k10--------
    rs1807955041,2
    C--86509788(+) TTGGAA/GTGCAG 1 -- us2k10--------
    rs1873874741,2
    --86509794(+) TGCAGC/TGGTGA 1 -- us2k10--------
    rs1908817601,2
    --86509829(+) TCCTGA/GGCTCA 1 -- us2k10--------
    rs1828968201,2
    --86510150(+) AAATAC/GCAGGC 1 -- us2k10--------
    rs1857067831,2
    C--86510174(+) TCACGC/TGTGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRSS23 (86502101 - 86663952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRSS23:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523704CNV Loss19592680
    nsv521505CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRSS23
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease from the University of Copenhagen DISEASES database for PRSS23:
    Cleft lip

    Find genes that share disorders with PRSS23           About GenesLikeMe

    Genetic Association Database (GAD): PRSS23
    Human Genome Epidemiology (HuGE) Navigator: PRSS23 (1 document)

    Export disorders for PRSS23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PRSS23 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with PRSS23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Use of genome-wide expression data to mine the &quot;Gray Zone&quot; of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    5. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PubMed id 16870946)1, 9 Miyakoshi K....Hennebold J.D. (Biol. Reprod. 2006)
    6. Serine protease PRSS23 is upregulated by estrogen receptor I+ and associated with proliferation of breast cancer cells. (PubMed id 22291950)1 Chan H.S....Chuang Y.J. (PLoS ONE 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PubMed id 19199708)1 Gonzalez-Begne M....Yates J.R. (J. Proteome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 11098 HGNC: 14370 AceView: PRSS23 Ensembl:ENSG00000150687 euGenes: HUgn11098
    ECgene: PRSS23 H-InvDB: PRSS23

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PRSS23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PRSS23 gene:
    Search GeneIP for patents involving PRSS23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PRSS23  
     OriGene qPCR primer pairs and template standards for PRSS23   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PRSS23  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRSS23   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PRSS23   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRSS23   OriGene Custom Protein Services for PRSS23  

     
     
     Block miRNA regulation of human, mouse, rat PRSS23 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PRSS23
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS23 Predesigned siRNA for gene silencing in human, mouse, rat PRSS23
     QuantiFast Probe-based Assays in human, mouse, rat PRSS23 QuantiTect SYBR Green Assays in human, mouse, rat PRSS23
     Custom PCR Arrays for PRSS23 Search Chromatin IP Primers for PRSS23
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRSS23  Search GeneGlobe Interaction Network for PRSS23
     Regulatory tfbs in PRSS23 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PRSS23 GenScript cDNA clones with any tag delivered in your preferred vector for PRSS23
     GenScript Custom Assay Services for PRSS23 GenScript Custom overexpressing Cell Line Services for PRSS23
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PRSS23 (PRS23)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PRSS23
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PRSS23 antibodies
     PRSS23 proteins
     Antibodies for PRSS23
     See all of Abcam's Antibodies, Kits and Proteins for PRSS23
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PRSS23
     Antibodies for PRSS23
     ELISAs for PRSS23
     CLIAs for PRSS23



     Browse ESI BIO Cell Lines and PureStem Progenitors for PRSS23
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS23
     SwitchGear 3'UTR luciferase reporter plasmids for PRSS23
     SwitchGear Promoter luciferase reporter plasmids for PRSS23
     Search ThermoFisher Antibodies for PRSS23
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS23
     Browse compounds at ApexBio
     Search Addgene for plasmids for PRSS23
      Search eBioscience for proteins for PRSS23
      Search eBioscience for elisas for PRSS23
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PRSS23
     antibodies-online antibodies for PRSS23 (3 products)
     antibodies-online kits for PRSS23 (17 products)
     antibodies-online peptides for PRSS23
     antibodies-online proteins for PRSS23 (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRSS23 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4