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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRSS23 Gene

protein-coding   GIFtS: 52
GCID: GC11P086511

Protease, Serine, 23

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protease, Serine, 231 2     Serine Protease 232
Putative Secreted Protein Zsig132 3     Serine Protease, Umbilical Endothelium2
ZSIG132 3     EC 3.4.21.-3
SIG132     EC 3.4.218
SPUVE2     EC 3.4.21.48

External Ids:    HGNC: 143701   Entrez Gene: 110982   Ensembl: ENSG000001506877   UniProtKB: O950843   

Export aliases for PRSS23 gene to outside databases

Previous GC identifer: GC11P086189


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRSS23 Gene:
This gene encodes a member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA
levels after ovulation was induced. This gene seems to be highly conserved in vertebrates and may be an important
ovarian protease. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRSS23 Gene: 
PRSS23 (protease, serine, 23) is a protein-coding gene. Diseases associated with PRSS23 include intrahepatic cholangiocarcinoma, and cleft lip. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS35.

Gene Wiki entry for PRSS23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRSS23 gene promoter:
         GR   STAT1   GR-beta   STAT1beta   STAT1alpha   YY1   FOXL1   Evi-1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS23 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRSS23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2

PRSS23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS23 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P086511:  view genomic region     (about GC identifiers)

Start:
86,502,101 bp from pter      End:
86,663,952 bp from pter
Size:
161,852 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRS23_HUMAN, O95084 (See protein sequence)
Recommended Name: Serine protease 23 precursor  
Size: 383 amino acids; 43001 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B2RDJ1 Q6IBI0

Explore the universe of human proteins at neXtProt for PRSS23: NX_O95084

Explore proteomics data for PRSS23 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95084

  • 4/7 DME Specific Peptides for PRSS23 (O95084) (see all 7)
     SGSGVYV  VLTAAHC  DYDYALLEL  SRRKRQIYGYD 

    PRSS23 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRSS23 Protein Expression
    REFSEQ proteins: NP_009104.1  
    ENSEMBL proteins: 
     ENSP00000435951   ENSP00000280258   ENSP00000436676   ENSP00000437268   ENSP00000393015  

    Human Recombinant Protein Products for PRSS23: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRSS23 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IDA--

    PRSS23 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for PRSS23


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRSS: Serine peptidases / Serine peptidases

    3 InterPro protein domains:
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry O95084

    ProtoNet protein and cluster: O95084

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: PRS23_HUMAN, O95084
    Similarity: Belongs to the peptidase S1 family


    PRSS23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    PRSS23 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PRSS23 (see all 21):
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    SwitchGear 3'UTR luciferase reporter plasmidPRSS23 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRSS23

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/39 Interacting proteins for PRSS23 (O950842, 3 ENSP000002802584) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHP1Q996532, 3MINT-63258 I2D: score=5 
    EFNA3P527972, 3MINT-63247 I2D: score=5 
    FXR1P511142, 3MINT-63255 I2D: score=5 
    GRK6P432502, 3MINT-63246 I2D: score=5 
    MAPK8IP2Q133872, 3MINT-63250 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    PRSS23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRSS23 (PRS23)

    Search CenterWatch for drugs/clinical trials and news about PRSS23 / PRS23

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRSS23 gene: 
    NM_007173.4  

    Unigene Cluster for PRSS23:

    Protease, serine, 23
    Hs.25338  [show with all ESTs]
    Unigene Representative Sequence: NM_007173
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527521 ENST00000280258(uc010rts.1 uc001pcb.3) ENST00000532234(uc001pcc.1)
    ENST00000533902 ENST00000531475 ENST00000533880 ENST00000532572(uc001pcd.3)
    ENST00000528769 ENST00000531521 ENST00000441050
    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PRSS23 (see all 21):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-576-3p hsa-miR-875-3p hsa-miR-607 hsa-miR-330-5p hsa-miR-548l hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidPRSS23 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS23
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                         Customized lentivirus expression plasmids for stable overexpression of PRSS23 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS23
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS23

    Additional mRNA sequence: 

    AF015287.1 AF193611.1 AK075362.1 AK304054.1 AK304301.1 AK315562.1 AK316508.1 AL136914.1 
    AY359033.1 BC001278.1 BC063022.1 CR456824.1 

    21 DOTS entries:

    DT.215865  DT.99936778  DT.95259185  DT.100030211  DT.95169263  DT.95169266  DT.99958064  DT.101973708 
    DT.217067  DT.95125042  DT.100715832  DT.100816993  DT.120735278  DT.120735288  DT.120735347  DT.92446656 
    DT.95116364  DT.95118891  DT.95150776  DT.97807838  DT.97847183 

    24/470 AceView cDNA sequences (see all 470):

    BQ009214 C01782 BU186640 BU618905 CR608853 BE876666 CB106316 BI223002 
    CR596876 BQ230952 AI094190 CR622497 BE327874 CR599725 BQ029812 AI371263 
    CB106897 BQ573866 CR623760 CR613177 CR624329 AU280399 AI337968 CR591812 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS23    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for PRSS23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRSS23 expression in normal human tissues (normalized intensities)      PRSS23 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRSS23 Expression
    About this image


    PRSS23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
             Peripheral blood endothelial colony-forming cells
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Uterus (Reproductive System)
             endometrial endothelial cell   

    See PRSS23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRSS23

    SOURCE GeneReport for Unigene cluster: Hs.25338
        SABiosciences Custom PCR Arrays for PRSS23
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS23 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss231 , 5 protease, serine, 231, 5 86.21(n)1
    91.1(a)1
      7 (49.90 cM)5
    764531  NM_029614.31  NP_083890.21 
     895077855 
    chicken
    (Gallus gallus)
    Aves PRSS231 protease, serine, 23 77.51(n)
    86.72(a)
      419017  XM_417210.2  XP_417210.3 
    lizard
    (Anolis carolinensis)
    Reptilia PRSS236
    Uncharacterized protein
    80(a)
    1 ↔ 1
    3(200137893-200155798)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb01h122 Transcribed sequence with weak similarity to protein more 75.9(n)    57090351 


    ENSEMBL Gene Tree for PRSS23 (if available)
    TreeFam Gene Tree for PRSS23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRSS23 gene
    PRSS352  
    1 SIMAP similar gene for PRSS23 using alignment to 5 protein entries:     PRS23_HUMAN (see all proteins):
    PRSS35

    PRSS23 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/300 SNPs in PRSS23 are shown (see all 300)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735207061,2
    C,F--86509497(+) GGAACG/AAAGGA 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1114522011,2
    F--86509522(+) TTGAGA/TCTGCA 1 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1395655321,2
    --86509528(+) CTGCAA/TTGGGC 1 -- us2k10--------
    rs1498218631,2
    --86509529(+) TGCATC/TGGGCA 1 -- us2k10--------
    rs1890550361,2
    --86509697(+) TTTGCA/GAGTTG 1 -- us2k10--------
    rs1807955041,2
    C--86509788(+) TTGGAA/GTGCAG 1 -- us2k10--------
    rs1873874741,2
    --86509794(+) TGCAGC/TGGTGA 1 -- us2k10--------
    rs1908817601,2
    --86509829(+) TCCTGA/GGCTCA 1 -- us2k10--------
    rs1828968201,2
    --86510150(+) AAATAC/GCAGGC 1 -- us2k10--------
    rs1857067831,2
    C--86510174(+) TCACGC/TGTGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRSS23 (86502101 - 86663952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRSS23:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523704CNV Loss19592680
    nsv521505CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    7 diseases for PRSS23:    About MalaCards
    intrahepatic cholangiocarcinoma    cleft lip    cholangiocarcinoma    obesity
    prostate cancer    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for PRSS23:
    Cleft lip

    PRSS23 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRSS23
    Human Genome Epidemiology (HuGE) Navigator: PRSS23 (1 document)

    Export disorders for PRSS23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRSS23 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with PRSS23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Use of genome-wide expression data to mine the ' Gray Zone' of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    5. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PubMed id 16870946)1, 9 Miyakoshi K....Hennebold J.D. (2006)
    6. Serine protease PRSS23 is upregulated by estrogen rece ptor a and associated with proliferation of breast cancer cells. (PubMed id 22291950)1 Chan H.S....Chuang Y.J. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11098 HGNC: 14370 AceView: PRSS23 Ensembl:ENSG00000150687 euGenes: HUgn11098
    ECgene: PRSS23 H-InvDB: PRSS23

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRSS23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRSS23 gene:
    Search GeneIP for patents involving PRSS23

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