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Aliases for PRSS23 Gene

Aliases for PRSS23 Gene

  • Protease, Serine, 23 2 3
  • Putative Secreted Protein Zsig13 3 4
  • ZSIG13 3 4
  • Serine Protease, Umbilical Endothelium 3
  • Serine Protease 23 3
  • EC 3.4.21.4 64
  • EC 3.4.21.- 4
  • EC 3.4.21 64
  • SIG13 3
  • SPUVE 3

External Ids for PRSS23 Gene

Summaries for PRSS23 Gene

Entrez Gene Summary for PRSS23 Gene

  • This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for PRSS23 Gene

PRSS23 (Protease, Serine, 23) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity.

Gene Wiki entry for PRSS23 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS23 Gene

Genomics for PRSS23 Gene

Genomic Location for PRSS23 Gene

Start:
86,791,059 bp from pter
End:
86,952,910 bp from pter
Size:
161,852 bases
Orientation:
Plus strand

Genomic View for PRSS23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS23 Gene

Regulatory Elements for PRSS23 Gene

Proteins for PRSS23 Gene

  • Protein details for PRSS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95084-PRS23_HUMAN
    Recommended name:
    Serine protease 23
    Protein Accession:
    O95084
    Secondary Accessions:
    • B2RDJ1
    • B4E2J3
    • Q6IBI0

    Protein attributes for PRSS23 Gene

    Size:
    383 amino acids
    Molecular mass:
    43001 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS23 Gene

Proteomics data for PRSS23 Gene at MOPED

Post-translational modifications for PRSS23 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys50
  • Glycosylation at Thr73, Asn93, and Asn207

Other Protein References for PRSS23 Gene

Domains for PRSS23 Gene

Gene Families for PRSS23 Gene

HGNC:
  • PRSS :Serine peptidases / Serine peptidases

UniProtKB/Swiss-Prot:

PRS23_HUMAN
Family:
  • Belongs to the peptidase S1 family.:
    • O95084
genes like me logo Genes that share domains with PRSS23: view

Function for PRSS23 Gene

Enzyme Numbers (IUBMB) for PRSS23 Gene

Gene Ontology (GO) - Molecular Function for PRSS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PRSS23: view

miRNA for PRSS23 Gene

miRTarBase miRNAs that target PRSS23

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRSS23 Gene

Localization for PRSS23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS23 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS23 Gene COMPARTMENTS Subcellular localization image for PRSS23 gene
Compartment Confidence
nucleus 4
extracellular 3
mitochondrion 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRSS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with PRSS23: view

Pathways for PRSS23 Gene

SuperPathways for PRSS23 Gene

No Data Available

Interacting Proteins for PRSS23 Gene

Gene Ontology (GO) - Biological Process for PRSS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS23: view

No data available for Pathways by source for PRSS23 Gene

Transcripts for PRSS23 Gene

Unigene Clusters for PRSS23 Gene

Protease, serine, 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS23 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for PRSS23 Gene

GeneLoc Exon Structure for
PRSS23
ECgene alternative splicing isoforms for
PRSS23

Expression for PRSS23 Gene

mRNA expression in normal human tissues for PRSS23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRSS23 Gene

SOURCE GeneReport for Unigene cluster for PRSS23 Gene Hs.25338

genes like me logo Genes that share expressions with PRSS23: view

Orthologs for PRSS23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS23 36
  • 99.56 (n)
  • 99.74 (a)
PRSS23 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS23 36
  • 87.73 (n)
  • 93.6 (a)
PRSS23 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS23 36
  • 88.54 (n)
  • 94.18 (a)
PRSS23 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss23 36
  • 86.21 (n)
  • 90.84 (a)
Prss23 16
Prss23 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRSS23 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS23 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss23 36
  • 85.47 (n)
  • 91.38 (a)
chicken
(Gallus gallus)
Aves PRSS23 36
  • 78.21 (n)
  • 87.53 (a)
PRSS23 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRSS23 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prss23 36
  • 70.9 (n)
  • 79.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8589 36
zebrafish
(Danio rerio)
Actinopterygii PRSS23 37
  • 49 (a)
OneToOne
wufb01h12 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToMany
Species with no ortholog for PRSS23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS23 Gene

ENSEMBL:
Gene Tree for PRSS23 (if available)
TreeFam:
Gene Tree for PRSS23 (if available)

Paralogs for PRSS23 Gene

Selected SIMAP similar genes for PRSS23 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PRSS23: view

No data available for Paralogs for PRSS23 Gene

Variants for PRSS23 Gene

Sequence variations from dbSNP and Humsavar for PRSS23 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs750789 -- 86,791,250(+) CAGCA(C/T)AGCCC intron-variant
rs754490 -- 86,792,065(-) GCACA(C/T)TGGGA intron-variant
rs868871 -- 86,908,726(-) TTCAC(A/G)TCTGA intron-variant
rs872619 -- 86,799,298(-) TTTTA(A/C)ATGAG upstream-variant-2KB, intron-variant
rs921871 -- 86,938,060(-) TGGGG(C/T)AACTA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PRSS23 Gene

Variant ID Type Subtype PubMed ID
nsv521505 CNV Gain 19592680
nsv523704 CNV Loss 19592680

Relevant External Links for PRSS23 Gene

HapMap Linkage Disequilibrium report
PRSS23

Disorders for PRSS23 Gene

(1) University of Copenhagen DISEASES for PRSS23 Gene

Relevant External Links for PRSS23

Genetic Association Database (GAD)
PRSS23
Human Genome Epidemiology (HuGE) Navigator
PRSS23
genes like me logo Genes that share disorders with PRSS23: view

No data available for UniProtKB/Swiss-Prot for PRSS23 Gene

Publications for PRSS23 Gene

  1. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PMID: 16870946) Miyakoshi K. … Hennebold J.D. (Biol. Reprod. 2006) 3 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 49

Products for PRSS23 Gene

Sources for PRSS23 Gene

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