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PRSS22 Gene

protein-coding   GIFtS: 50
GCID: GC16M002902

Protease, Serine, 22

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 221 2     prosemin2
Brain-Specific Serine Protease 41 2     Protease, Serine S1 Family Member 222
Serine Protease 222 3     BSSP43
Serine Protease 262 3     EC 3.4.21.-3
Tryptase Epsilon2 3     PRSS263
BSSP-42 3     EC 3.4.218
hBSSP-42     

External Ids:    HGNC: 143681   Entrez Gene: 640632   Ensembl: ENSG000000050017   OMIM: 6093435   UniProtKB: Q9GZN43   

Export aliases for PRSS22 gene to outside databases

Previous GC identifers: GC16M002923 GC16M002903 GC16M002842 GC16M002869


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRSS22 Gene:
This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a
developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PRSS22 Gene:
PRSS22 (protease, serine, 22) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS46.

UniProtKB/Swiss-Prot: BSSP4_HUMAN, Q9GZN4
Function: Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA

Gene Wiki entry for PRSS22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRSS22 gene promoter:
         HEN1   STAT1   AP-1   FOXD3   Pax-2   MyoD   Cart-1   Pax-2a   ZIC2/Zic2   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS22 promoter sequence
   Search Chromatin IP Primers for PRSS22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PRSS22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS22 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002902:  view genomic region     (about GC identifiers)

Start:
2,902,728 bp from pter      End:
2,908,171 bp from pter
Size:
5,444 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BSSP4_HUMAN, Q9GZN4 (See protein sequence)
Recommended Name: Brain-specific serine protease 4 precursor  
Size: 317 amino acids; 33732 Da
Sequence caution: Sequence=AAB93671.1; Type=Erroneous gene model prediction; Sequence=AAQ88762.1; Type=Erroneous
initiation;
Secondary accessions: O43342 Q6UXE0

Explore the universe of human proteins at neXtProt for PRSS22: NX_Q9GZN4

Explore proteomics data for PRSS22 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn70
  • 4 DME Specific Peptides for PRSS22 (Q9GZN4)
     DIALVRL  GDSGGPL  SWGEGCA  CWISGWG 


    See PRSS22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071402.1  
    ENSEMBL proteins: 
     ENSP00000161006   ENSP00000458506   ENSP00000458562  

    PRSS22 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PRSS22
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRSS22 

    PRSS22 Antibody Products:

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    Novus Biologicals PRSS22 Antibodies
    Abcam antibodies for PRSS22
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    LSBio Antibodies in human, mouse, rat for PRSS22

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    Search eBioscience for ELISAs for PRSS22 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZN4

    ProtoNet protein and cluster: Q9GZN4

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: BSSP4_HUMAN, Q9GZN4
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PRSS22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BSSP4_HUMAN, Q9GZN4
    Function: Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    Find genes that share ontologies with PRSS22           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Prss22 (no phenotypes)

    Find genes that share phenotypes with PRSS22           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prss22tm1Lex for PRSS22

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS22
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRSS22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRSS22
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRSS22

    miRNA
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    miRTarBase miRNAs that target PRSS22:
    hsa-mir-132-3p (MIRT021776)

    Block miRNA regulation of human, mouse, rat PRSS22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRSS22 (see all 15):
    hsa-miR-98 hsa-miR-520d-5p hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-miR-3927
    SwitchGear 3'UTR luciferase reporter plasmidPRSS22 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRSS22
    Predesigned siRNA for gene silencing in human, mouse, rat PRSS22

    Gene Editing
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    OriGene ORF clones in mouse, rat for PRSS22
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    GenScript: all cDNA clones in your preferred vector: PRSS22 (NM_022119)
    Sino Biological Human cDNA Clone for PRSS22
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS22

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BSSP4_HUMAN, Q9GZN4: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with PRSS22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS22
    Interactions:

        Search GeneGlobe Interaction Network for PRSS22

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with PRSS22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS22 (BSSP4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRSS22 gene: 
    NM_022119.3  

    Unigene Cluster for PRSS22:

    Protease, serine, 22
    Hs.459709  [show with all ESTs]
    Unigene Representative Sequence: BC009726
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000161006(uc002cry.1) ENST00000571228 ENST00000575164 ENST00000576381
    ENST00000572061 ENST00000574768 ENST00000577177 ENST00000570950
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRSS22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRSS22 (see all 15):
    hsa-miR-98 hsa-miR-520d-5p hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-miR-3927
    SwitchGear 3'UTR luciferase reporter plasmidPRSS22 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PRSS22
    Predesigned siRNA for gene silencing in human, mouse, rat PRSS22
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    OriGene clones in human, mouse for PRSS22 (see all 6)
    OriGene ORF clones in mouse, rat for PRSS22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRSS22 (NM_022119)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS22
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PRSS22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRSS22
      QuantiTect SYBR Green Assays in human, mouse, rat PRSS22
      QuantiFast Probe-based Assays in human, mouse, rat PRSS22

    Additional mRNA sequence: 

    AB010779.1 AF321182.1 AK309624.1 AK310904.1 AY358396.1 BC009726.1 

    6 DOTS entries:

    DT.40126110  DT.95355311  DT.97839187  DT.100783115  DT.91934276  DT.99948582 

    Selected AceView cDNA sequences (see all 73):

    BE907706 AF321182 BX356243 AB010779 BM844455 CA489887 AI274014 BX280281 
    AI940071 BM818012 CR608374 AW583133 CR591551 BM845831 NM_022119 CR626637 
    BX395818 BF871783 BC009726 BG824600 BM976630 BX334710 BX395817 BQ893064 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS22    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b
    SP1:                          -                                             
    SP2:                    -     -     -     -     -                           
    SP3:                    -     -                                             
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for PRSS22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCCGCCCC
    PRSS22 Expression
    About this image


    PRSS22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Stomach (Gastrointestinal Tract)
    PRSS22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459709

    UniProtKB/Swiss-Prot: BSSP4_HUMAN, Q9GZN4
    Tissue specificity: Expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and
    fetal lung. Scarce in adult lung. Expressed at low levels in placenta, pancreas, prostate and thyroid gland

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRSS22 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss221 , 5 protease, serine, 225
    protease, serine 221
    80.35(n)1
    77.81(a)1
      17 (12.18 cM)5
    708351  NM_133731.21  NP_598492.21 
     239935355 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    46(a)
    43(a)
    many ↔ many
    many ↔ many
    GL343287.1(1697243-1701085)
    GL343287.1(1650442-1668815)
    fruit fly
    (Drosophila melanogaster)
    Insecta Sb3
    CG81701
    cytoskeleton organization and
    biogenesis serine-type more3
    CG81701
    37(a)
    (best of 7)3
    48.45(n)1
    37.29(a)1
      3 89B93
    359081  NM_001043068.11  NP_001036533.11 


    ENSEMBL Gene Tree for PRSS22 (if available)
    TreeFam Gene Tree for PRSS22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS22 gene
    PRSS462  PRSS482  PRSS272  TMPRSS92  PRSS212  PRSS452  TPSG12  TPSD12  
    PRSS382  TPSAB12  PRSS532  PRSS502  PRSS422  PRSS362  PRSS332  PRSS82  
    TPSB22  
    Selected SIMAP similar genes for PRSS22 using alignment to 3 protein entries:     BSSP4_HUMAN (see all proteins) (see all similar genes):
    PRSS27    serase-1B    TMPRSS9    F11    TMPRSS11B    TMPRSS11F
    TMPRSS6    TPSG1    TPSAB1    TPSB2    KLKB1    tryptaseC
    TMPRSS15    PRSS21    PRSS33    TMPRSS11A    TMPRSS5    DESC1

    Find genes that share paralogs with PRSS22           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS22 (see all 217)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911573781,2
    --2902302(+) CTGAGG/TCCCCT 1 -- ds50010--------
    rs1499524981,2
    --2902333(+) CAGAAC/GGGGGG 1 -- ds50010--------
    rs71863261,2
    C,F,A,H--2902431(+) TTCGGG/AGTCCC 1 -- ds500121Minor allele frequency- A:0.47NS EA NA WA CSA 2335
    rs1137338901,2
    C,F--2902439(+) CCCAAT/CCCCTC 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs124483851,2
    H--2902449(+) CTCCTA/CCCCTT 1 -- ds50010--------
    rs1153399501,2
    F--2902510(+) CCATCG/AGCTGC 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs3715107891,2
    C--2902511(+) ATCGG-/ATGCC 
            
    CTGCC
    1 -- ds50010--------
    rs1420397681,2
    --2902654(+) TAGGCC/TAACAT 1 -- ds50010--------
    rs127861,2
    C,F,A,H--2902832(-) CCCCAG/CCGCTT 1 -- ut31 ese310Minor allele frequency- C:0.20MN NS EA NA CSA WA 1025
    rs681626391,2
    C--2902975(+) CCCCC-/AGAGGT
            
    AGAGG
    1 -- cds12Minor allele frequency- AGAGGT:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for PRSS22 (2902728 - 2908171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PRSS22:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509587CNV Insertion20534489
    nsv1712CNV Insertion18451855
    dgv2574n71CNV Loss21882294
    nsv905165CNV Loss21882294
    nsv905152CNV Loss21882294
    nsv905170CNV Loss21882294
    dgv2575n71CNV Loss21882294
    nsv905169CNV Loss21882294
    nsv905162CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRSS22
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609343    OMIM disorders: --


    Find genes that share disorders with PRSS22           About GenesLikeMe


    Export disorders for PRSS22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS22 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PRSS22)
        Utopia: connect your pdf to the dynamic
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    1. Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. (PubMed id 11602603)1, 2, 3, 9 Wong G.W.... Stevens R.L. (J. Biol. Chem. 2001)
    2. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. (PubMed id 15701722)1, 3, 9 Yasuda S....Stevens R.L. (Blood 2005)
    3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells. (PubMed id 16176265)1, 9 Mitsui S....Yamaguchi N. (FEBS J. 2005)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 
    10. The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. (PubMed id 18948266)9 Li W....Kirchhofer D. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64063 HGNC: 14368 AceView: PRSS22 Ensembl:ENSG00000005001 euGenes: HUgn64063
    ECgene: PRSS22 H-InvDB: PRSS22

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS22 gene:
    Search GeneIP for patents involving PRSS22

    GeneCards and IP:
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