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Aliases for PRSS22 Gene

Aliases for PRSS22 Gene

  • Protease, Serine 22 2 3 5
  • Serine Protease 22 3 4
  • Serine Protease 26 3 4
  • Tryptase Epsilon 3 4
  • BSSP-4 3 4
  • Protease, Serine S1 Family Member 22 3
  • Brain-Specific Serine Protease 4 2
  • Protease, Serine, 22 3
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • Prosemin 3
  • SP001LA 3
  • HBSSP-4 3
  • PRSS26 4
  • BSSP4 4

External Ids for PRSS22 Gene

Previous GeneCards Identifiers for PRSS22 Gene

  • GC16M002923
  • GC16M002903
  • GC16M002842
  • GC16M002902
  • GC16M002869

Summaries for PRSS22 Gene

Entrez Gene Summary for PRSS22 Gene

  • This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS22 Gene

PRSS22 (Protease, Serine 22) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

UniProtKB/Swiss-Prot for PRSS22 Gene

  • Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.

Gene Wiki entry for PRSS22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS22 Gene

Genomics for PRSS22 Gene

Regulatory Elements for PRSS22 Gene

Enhancers for PRSS22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS22 on UCSC Golden Path with GeneCards custom track

Promoters for PRSS22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRSS22 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS22 Gene

2,852,727 bp from pter
2,858,630 bp from pter
5,904 bases
Minus strand

Genomic View for PRSS22 Gene

Genes around PRSS22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS22 Gene

Proteins for PRSS22 Gene

  • Protein details for PRSS22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain-specific serine protease 4
    Protein Accession:
    Secondary Accessions:
    • O43342
    • Q6UXE0

    Protein attributes for PRSS22 Gene

    317 amino acids
    Molecular mass:
    33732 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB93671.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAQ88762.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PRSS22 Gene

Proteomics data for PRSS22 Gene at MOPED

Selected DME Specific Peptides for PRSS22 Gene

Post-translational modifications for PRSS22 Gene

Other Protein References for PRSS22 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRSS22 (Tryptase epsilon/BSSP-4)

Domains & Families for PRSS22 Gene

Gene Families for PRSS22 Gene

Suggested Antigen Peptide Sequences for PRSS22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS22: view

Function for PRSS22 Gene

Molecular function for PRSS22 Gene

UniProtKB/Swiss-Prot Function:
Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.

Enzyme Numbers (IUBMB) for PRSS22 Gene

genes like me logo Genes that share phenotypes with PRSS22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS22

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS22 Gene

Localization for PRSS22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS22 Gene


Subcellular locations from

Jensen Localization Image for PRSS22 Gene COMPARTMENTS Subcellular localization image for PRSS22 gene
Compartment Confidence
extracellular 4
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PRSS22 Gene

Pathways & Interactions for PRSS22 Gene

SuperPathways for PRSS22 Gene

No Data Available

Interacting Proteins for PRSS22 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000161006 for PRSS22 Gene via STRING

Gene Ontology (GO) - Biological Process for PRSS22 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRSS22 Gene

Drugs & Compounds for PRSS22 Gene

(1) Drugs for PRSS22 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMSF Pharma Serine proteinases inhibitor, irreversible 0

(1) ApexBio Compounds for PRSS22 Gene

Compound Action Cas Number
PMSF Serine proteinases inhibitor, irreversible 329-98-6
genes like me logo Genes that share compounds with PRSS22: view

Transcripts for PRSS22 Gene

Unigene Clusters for PRSS22 Gene

Protease, serine, 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - - - - -
SP3: - -

Relevant External Links for PRSS22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS22 Gene

mRNA expression in normal human tissues for PRSS22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS22 Gene

This gene is overexpressed in Esophagus - Mucosa (x15.1), Minor Salivary Gland (x12.8), and Cervix - Ectocervix (x5.1).

Protein differential expression in normal tissues from HIPED for PRSS22 Gene

This gene is overexpressed in Esophagus (35.0) and Islet of Langerhans (34.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS22 Gene

SOURCE GeneReport for Unigene cluster for PRSS22 Gene Hs.459709

mRNA Expression by UniProt/SwissProt for PRSS22 Gene

Tissue specificity: Expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung. Scarce in adult lung. Expressed at low levels in placenta, pancreas, prostate and thyroid gland.
genes like me logo Genes that share expression patterns with PRSS22: view

Protein tissue co-expression partners for PRSS22 Gene

Primer Products

Orthologs for PRSS22 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRSS22 35
  • 83.05 (n)
  • 79.26 (a)
PRSS22 36
  • 76 (a)
(Canis familiaris)
Mammalia PRSS22 35
  • 83.33 (n)
  • 79.77 (a)
PRSS22 36
  • 76 (a)
(Mus musculus)
Mammalia Prss22 35
  • 80.35 (n)
  • 77.81 (a)
Prss22 16
Prss22 36
  • 77 (a)
(Pan troglodytes)
Mammalia PRSS22 35
  • 99.26 (n)
  • 98.74 (a)
PRSS22 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Prss22 35
  • 79.14 (n)
  • 76.49 (a)
(Monodelphis domestica)
Mammalia PRSS22 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia PRSS22 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
-- 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1299 37
  • 33 (a)
CG6865 37
  • 32 (a)
CG7432 37
  • 32 (a)
CG8170 37
  • 36 (a)
CG8172 37
  • 31 (a)
CG9733 37
  • 33 (a)
Sb 37
  • 37 (a)
CG8170 35
  • 48.45 (n)
  • 37.29 (a)
(Caenorhabditis elegans)
Secernentea C07G1.1 37
  • 35 (a)
Species with no ortholog for PRSS22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PRSS22 Gene

Gene Tree for PRSS22 (if available)
Gene Tree for PRSS22 (if available)

Paralogs for PRSS22 Gene

genes like me logo Genes that share paralogs with PRSS22: view

Variants for PRSS22 Gene

Sequence variations from dbSNP and Humsavar for PRSS22 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs12786 -- 2,852,831(-) CCCCA(C/G)CGCTT utr-variant-3-prime
rs1054912 -- 2,853,046(-) ATCCA(C/G)ATCTG utr-variant-3-prime
rs78722056 -- 2,855,365(+) AAAAA(A/G)AAGAA intron-variant
rs78795235 -- 2,854,612(+) CTTAG(C/T)CTCTA intron-variant
rs28679561 -- 2,855,809(+) TGCCA(G/T)GCCCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PRSS22 Gene

Variant ID Type Subtype PubMed ID
nsv905152 CNV Loss 21882294
nsv905162 CNV Gain 21882294
nsv905165 CNV Loss 21882294
nsv905169 CNV Loss 21882294
nsv905170 CNV Loss 21882294
dgv2574n71 CNV Loss 21882294
nsv509587 CNV Insertion 20534489
dgv2575n71 CNV Loss 21882294
nsv1712 CNV Insertion 18451855

Variation tolerance for PRSS22 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRSS22 Gene

Disorders for PRSS22 Gene

Relevant External Links for PRSS22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRSS22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS22 Gene

Publications for PRSS22 Gene

  1. Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. (PMID: 11602603) Wong G.W. … Stevens R.L. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. (PMID: 15701722) Yasuda S. … Stevens R.L. (Blood 2005) 2 3 23
  3. A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells. (PMID: 16176265) Mitsui S. … Yamaguchi N. (FEBS J. 2005) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling. (PMID: 24980078) Chen C.Y. … Lin K.H. (Mol. Cancer 2014) 3

Products for PRSS22 Gene

Sources for PRSS22 Gene